JP2015513897A5 - - Google Patents

Info

Publication number

JP2015513897A5

JP2015513897A5 JP2015502141A JP2015502141A JP2015513897A5 JP 2015513897 A5 JP2015513897 A5 JP 2015513897A5 JP 2015502141 A JP2015502141 A JP 2015502141A JP 2015502141 A JP2015502141 A JP 2015502141A JP 2015513897 A5 JP2015513897 A5 JP 2015513897A5

Authority

JP

Japan

Prior art keywords

nucleic acid

utr

acid molecule

artificial nucleic

nucleotides

Prior art date

2013-03-27

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Granted

Links

• Espacenet
• Global Dossier
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• 150000007523 nucleic acids Chemical group 0.000 claims 30
• 108020005345 3' Untranslated Regions Proteins 0.000 claims 24
• 108020004707 nucleic acids Proteins 0.000 claims 24
• 102000039446 nucleic acids Human genes 0.000 claims 24
• 108700026244 Open Reading Frames Proteins 0.000 claims 13
• 239000013598 vector Substances 0.000 claims 13
• 239000002773 nucleotide Substances 0.000 claims 11
• 125000003729 nucleotide group Chemical group 0.000 claims 11
• 108010088751 Albumins Proteins 0.000 claims 9
• GFFGJBXGBJISGV-UHFFFAOYSA-N adenyl group Chemical class N1=CN=C2N=CNC2=C1N GFFGJBXGBJISGV-UHFFFAOYSA-N 0.000 claims 8
• 108091006905 Human Serum Albumin Proteins 0.000 claims 5
• 108091028043 Nucleic acid sequence Proteins 0.000 claims 4
• 210000004027 cell Anatomy 0.000 claims 4
• 239000008194 pharmaceutical composition Substances 0.000 claims 4
• 230000008488 polyadenylation Effects 0.000 claims 4
• 108091034057 RNA (poly(A)) Proteins 0.000 claims 3
• 108091036066 Three prime untranslated region Proteins 0.000 claims 3
• 239000012634 fragment Substances 0.000 claims 3
• FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 2
• 108020003589 5' Untranslated Regions Proteins 0.000 claims 2
• 108020004705 Codon Proteins 0.000 claims 2
• 108091035707 Consensus sequence Proteins 0.000 claims 2
• 102100021519 Hemoglobin subunit beta Human genes 0.000 claims 2
• 108091005904 Hemoglobin subunit beta Proteins 0.000 claims 2
• 108010033040 Histones Proteins 0.000 claims 2
• 101000930457 Rattus norvegicus Albumin Proteins 0.000 claims 2
• 229960000027 human factor ix Drugs 0.000 claims 2
• 239000013600 plasmid vector Substances 0.000 claims 2
• 108091032973 (ribonucleotides)n+m Proteins 0.000 claims 1
• 102000009027 Albumins Human genes 0.000 claims 1
• 108091033380 Coding strand Proteins 0.000 claims 1
• 108020004414 DNA Proteins 0.000 claims 1
• 102000008100 Human Serum Albumin Human genes 0.000 claims 1
• 101000930477 Mus musculus Albumin Proteins 0.000 claims 1
• 241000282516 Papio anubis Species 0.000 claims 1
• 241000288906 Primates Species 0.000 claims 1
• 241000251539 Vertebrata <Metazoa> Species 0.000 claims 1
• 239000002671 adjuvant Substances 0.000 claims 1
• 230000003796 beauty Effects 0.000 claims 1
• 238000010367 cloning Methods 0.000 claims 1
• 239000003085 diluting agent Substances 0.000 claims 1
• 239000003814 drug Substances 0.000 claims 1
• 238000001415 gene therapy Methods 0.000 claims 1
• 210000004962 mammalian cell Anatomy 0.000 claims 1
• 108020004999 messenger RNA Proteins 0.000 claims 1
• 239000000546 pharmaceutical excipient Substances 0.000 claims 1
• 108091008146 restriction endonucleases Proteins 0.000 claims 1
• 238000011144 upstream manufacturing Methods 0.000 claims 1
• 229960005486 vaccine Drugs 0.000 claims 1
• 239000013603 viral vector Substances 0.000 claims 1