TWI716758B - 初代細胞基因編輯 - Google Patents

初代細胞基因編輯 Download PDF

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TWI716758B
TWI716758B TW107138453A TW107138453A TWI716758B TW I716758 B TWI716758 B TW I716758B TW 107138453 A TW107138453 A TW 107138453A TW 107138453 A TW107138453 A TW 107138453A TW I716758 B TWI716758 B TW I716758B
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cells
nucleotide sequence
tcr
cell
gene
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TW107138453A
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Chinese (zh)
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TW201934754A (zh
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凱爾 馬汀 賈可比
艾利西斯 法蘭蘇索夫
凱須曼 史戴芬尼 曼德爾
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美商Ｐａｃｔ製藥公司
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    • C12N15/09—Recombinant DNA-technology
    • C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
    • C12N15/90—Stable introduction of foreign DNA into chromosome
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    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/14—Blood; Artificial blood
    • A61K35/17—Lymphocytes; B-cells; T-cells; Natural killer cells; Interferon-activated or cytokine-activated lymphocytes
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00—Cellular immunotherapy
    • A61K40/10—Cellular immunotherapy characterised by the cell type used
    • A61K40/11—T-cells, e.g. tumour infiltrating lymphocytes [TIL] or regulatory T [Treg] cells; Lymphokine-activated killer [LAK] cells
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    • A61K40/00—Cellular immunotherapy
    • A61K40/30—Cellular immunotherapy characterised by the recombinant expression of specific molecules in the cells of the immune system
    • A61K40/32—T-cell receptors [TCR]
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00—Cellular immunotherapy
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    • A61K40/41—Vertebrate antigens
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    • A61K40/4201—Neoantigens
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    • A61K40/41—Vertebrate antigens
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    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
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    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
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    • C12N15/62—DNA sequences coding for fusion proteins
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    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
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    • C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
    • C12N15/90—Stable introduction of foreign DNA into chromosome
    • C12N15/902—Stable introduction of foreign DNA into chromosome using homologous recombination
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    • C12N5/06—Animal cells or tissues; Human cells or tissues
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    • C12N5/0602—Vertebrate cells
    • C12N5/0634—Cells from the blood or the immune system
    • C12N5/0646—Natural killers cells [NK], NKT cells
    • A—HUMAN NECESSITIES
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    • A61K2239/00—Indexing codes associated with cellular immunotherapy of group A61K40/00
    • A61K2239/38—Indexing codes associated with cellular immunotherapy of group A61K40/00 characterised by the dose, timing or administration schedule
    • A—HUMAN NECESSITIES
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    • A61K2239/46—Indexing codes associated with cellular immunotherapy of group A61K40/00 characterised by the cancer treated
    • A61K2239/48—Blood cells, e.g. leukemia or lymphoma
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    • C07K2319/00—Fusion polypeptide
    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
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  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
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TW107138453A 2017-10-30 2018-10-30 初代細胞基因編輯 TWI716758B (zh)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US201762579113P 2017-10-30 2017-10-30
US201762579114P 2017-10-30 2017-10-30
US62/579,114 2017-10-30
US62/579,113 2017-10-30

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Publication Number Publication Date
TW201934754A TW201934754A (zh) 2019-09-01
TWI716758B true TWI716758B (zh) 2021-01-21

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TW107138453A TWI716758B (zh) 2017-10-30 2018-10-30 初代細胞基因編輯

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US (7) US10584357B2 (enExample)
EP (1) EP3703712A4 (enExample)
JP (2) JP7397791B2 (enExample)
CN (2) CN117904055A (enExample)
AU (1) AU2018357861B2 (enExample)
BR (1) BR112020008704A2 (enExample)
CA (1) CA3081320A1 (enExample)
IL (1) IL274351B2 (enExample)
MX (1) MX2020004541A (enExample)
RU (1) RU2020116585A (enExample)
SG (1) SG11202004026QA (enExample)
TW (1) TWI716758B (enExample)
WO (1) WO2019089610A1 (enExample)

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CA3020330A1 (en) * 2016-04-07 2017-10-12 Bluebird Bio, Inc. Chimeric antigen receptor t cell compositions
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KR102503130B1 (ko) * 2017-10-27 2023-02-24 더 리전트 오브 더 유니버시티 오브 캘리포니아 내인성 t 세포 수용체의 표적화된 대체
MX2020004541A (es) * 2017-10-30 2021-04-12 Pact Pharma Inc Edicion de genes de celulas primarias.
SG11202009761YA (en) 2018-04-02 2020-10-29 Pact Pharma Inc Peptide-mhc compacts
AU2019362879A1 (en) * 2018-10-16 2021-05-27 Intellia Therapeutics, Inc. Compositions and methods for immunotherapy
AU2020264484A1 (en) 2019-05-01 2021-11-04 Adoc Ssf, Llc Compositions and methods for the treatment of cancer using a CDB engineered T cell therapy
EP4010463A4 (en) * 2019-08-05 2024-05-08 Cartherics Pty. Ltd. IMMUNE CELLS EXPRESSING MODIFIED CELL RECEPTORS AND METHOD FOR THE PRODUCTION
EP3999651A4 (en) 2019-08-26 2023-07-26 PACT Pharma, Inc. METHOD OF EXECUTING GUIDE-SEQ ON PRIMARY HUMAN T-CELLS
TW202128196A (zh) * 2019-10-08 2021-08-01 美商Ｐａｃｔ製藥公司 使用基因改造之自體ｔ細胞免疫療法之治療方法
WO2021072218A1 (en) * 2019-10-10 2021-04-15 Pact Pharma, Inc. Method of treating immunotherapy non-responders with an autologous cell therapy
CA3171369A1 (en) * 2020-02-28 2021-09-02 Wisconsin Alumni Research Foundation Nonviral generation of genome edited chimeric antigen receptor t cells
CA3174943A1 (en) * 2020-04-24 2021-10-28 Kyle JACOBY Methods of determining gene editing efficiencies in cells
WO2021252898A1 (en) * 2020-06-12 2021-12-16 Pact Pharma, Inc. Compositions and methods of manufacturing autologous t cell therapies
IL300994A (en) * 2020-08-28 2023-04-01 Arsenal Biosciences Inc Transgenic immune cells with priming receptors
AU2021368557A1 (en) * 2020-10-27 2023-06-08 Adoc Ssf, Llc Compositions and methods for the treatment of cancer using next generation engineered t cell therapy
KR20230160885A (ko) * 2021-03-24 2023-11-24 제넨테크, 인크. T 림프구에서 효율적인 tcr 유전자 편집
CN115867645A (zh) * 2021-05-18 2023-03-28 赛斯尔擎生物技术（上海）有限公司 修饰细胞的方法
KR20240021216A (ko) 2021-06-11 2024-02-16 팩트 파마, 인크. 세포 생성물을 감정하는 방법
AU2024228388A1 (en) 2023-02-27 2025-10-02 Adaptive Biotechnologies Corp. Therapeutic t cell receptors targeting kras g12d

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WO2017062451A1 (en) * 2015-10-05 2017-04-13 Precision Biosciences, Inc. Genetically-modified cells comprising a modified human t cell receptor alpha constant region gene

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