TWI716758B - 初代細胞基因編輯 - Google Patents

初代細胞基因編輯 Download PDF

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TWI716758B
TWI716758B TW107138453A TW107138453A TWI716758B TW I716758 B TWI716758 B TW I716758B TW 107138453 A TW107138453 A TW 107138453A TW 107138453 A TW107138453 A TW 107138453A TW I716758 B TWI716758 B TW I716758B
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cells
nucleotide sequence
tcr
cell
gene
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TW107138453A
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Chinese (zh)
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TW201934754A (zh
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凱爾 馬汀 賈可比
艾利西斯 法蘭蘇索夫
凱須曼 史戴芬尼 曼德爾
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美商Ｐａｃｔ製藥公司
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    • C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
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    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/14—Blood; Artificial blood
    • A61K35/17—Lymphocytes; B-cells; T-cells; Natural killer cells; Interferon-activated or cytokine-activated lymphocytes
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00—Cellular immunotherapy
    • A61K40/10—Cellular immunotherapy characterised by the cell type used
    • A61K40/11—T-cells, e.g. tumour infiltrating lymphocytes [TIL] or regulatory T [Treg] cells; Lymphokine-activated killer [LAK] cells
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    • A61K40/32—T-cell receptors [TCR]
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    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
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    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
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    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
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    • C12N5/06—Animal cells or tissues; Human cells or tissues
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    • C12N5/0634—Cells from the blood or the immune system
    • C12N5/0646—Natural killers cells [NK], NKT cells
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    • A61K2239/00—Indexing codes associated with cellular immunotherapy of group A61K40/00
    • A61K2239/38—Indexing codes associated with cellular immunotherapy of group A61K40/00 characterised by the dose, timing or administration schedule
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    • A61K2239/46—Indexing codes associated with cellular immunotherapy of group A61K40/00 characterised by the cancer treated
    • A61K2239/48—Blood cells, e.g. leukemia or lymphoma
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    • C07K2319/00—Fusion polypeptide
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TW107138453A 2017-10-30 2018-10-30 初代細胞基因編輯 TWI716758B (zh)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US201762579113P 2017-10-30 2017-10-30
US201762579114P 2017-10-30 2017-10-30
US62/579,113 2017-10-30
US62/579,114 2017-10-30

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TW201934754A TW201934754A (zh) 2019-09-01
TWI716758B true TWI716758B (zh) 2021-01-21

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US (7) US10550406B2 (enExample)
EP (1) EP3703712A4 (enExample)
JP (2) JP7397791B2 (enExample)
CN (2) CN117904055A (enExample)
AU (1) AU2018357861B2 (enExample)
BR (1) BR112020008704A2 (enExample)
CA (1) CA3081320A1 (enExample)
IL (1) IL274351B2 (enExample)
MX (1) MX2020004541A (enExample)
RU (1) RU2020116585A (enExample)
SG (1) SG11202004026QA (enExample)
TW (1) TWI716758B (enExample)
WO (1) WO2019089610A1 (enExample)

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AU2017248259A1 (en) * 2016-04-07 2018-10-25 Bluebird Bio, Inc. Chimeric antigen receptor T cell compositions
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SG11202003798TA (en) * 2017-10-27 2020-05-28 Univ California Targeted replacement of endogenous t cell receptors
EP3703712A4 (en) * 2017-10-30 2021-09-22 PACT Pharma, Inc. EDITING PRIMARY CELL GENES
KR20200138334A (ko) 2018-04-02 2020-12-09 팩트 파마, 인크. 펩티드-MHC comPACT
CA3116132A1 (en) * 2018-10-16 2020-04-23 Intellia Therapeutics, Inc. Compositions and methods for immunotherapy
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AU2020325225A1 (en) * 2019-08-05 2022-03-24 Cartherics Pty. Ltd. Immune cells expressing modified cell receptors and methods of making
US12359247B2 (en) 2019-08-26 2025-07-15 Adoc Ssf, Llc Methods of performing GUIDE-Seq on primary human T cells
IL291935A (en) * 2019-10-08 2022-06-01 Pact Pharma Inc Methods for immunotherapy of genetically modified autologous t cells
EP4041293A1 (en) * 2019-10-10 2022-08-17 PACT Pharma, Inc. Method of treating immunotherapy non-responders with an autologous cell therapy
EP4110356A4 (en) * 2020-02-28 2024-03-27 Wisconsin Alumni Research Foundation NON-VIRAL GENERATION OF CHIMERIC ANTIGEN RECEPTOR T CELLS OBTAINED BY GENE EDITING
AU2021261011A1 (en) * 2020-04-24 2022-11-10 Pact Pharma, Inc. Methods of determining gene editing efficiencies in cells
WO2021252898A1 (en) * 2020-06-12 2021-12-16 Pact Pharma, Inc. Compositions and methods of manufacturing autologous t cell therapies
IL300994A (en) * 2020-08-28 2023-04-01 Arsenal Biosciences Inc Transgenic immune cells with priming receptors
TW202233830A (zh) * 2020-10-27 2022-09-01 美商Ｐａｃｔ製藥公司 使用下一代工程化t細胞療法治療癌症之組合物及方法
WO2022204443A1 (en) * 2021-03-24 2022-09-29 Genentech, Inc. Efficient tcr gene editing in t lymphocytes
TW202309272A (zh) * 2021-03-24 2023-03-01 美商建南德克公司 Ｔ淋巴球中之高效ｔｃｒ基因編輯
WO2022242644A1 (zh) * 2021-05-18 2022-11-24 赛斯尔擎生物技术（上海）有限公司 修饰细胞的方法
JP2024523014A (ja) 2021-06-11 2024-06-25 パクト ファーマ インコーポレイテッド 細胞製剤を査定する方法
US20260232734A1 (en) 2023-02-27 2026-08-13 Adaptive Biotechnologies Corporation Therapeutic T-Cell Receptors Targeting KRAS G12D

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