JP2012518420A5 - - Google Patents
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- Publication number
- JP2012518420A5 JP2012518420A5 JP2011551315A JP2011551315A JP2012518420A5 JP 2012518420 A5 JP2012518420 A5 JP 2012518420A5 JP 2011551315 A JP2011551315 A JP 2011551315A JP 2011551315 A JP2011551315 A JP 2011551315A JP 2012518420 A5 JP2012518420 A5 JP 2012518420A5
- Authority
- JP
- Japan
- Prior art keywords
- seq
- amino acid
- residue
- polypeptide
- recombinant polypeptide
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 229920001184 polypeptide Polymers 0.000 claims 18
- 102000004196 processed proteins & peptides Human genes 0.000 claims 18
- 108090000765 processed proteins & peptides Proteins 0.000 claims 18
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 11
- 125000000539 amino acid group Chemical group 0.000 claims 10
- 125000003275 alpha amino acid group Chemical group 0.000 claims 5
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 2
- 210000001519 tissue Anatomy 0.000 claims 2
- 210000000988 bone and bone Anatomy 0.000 claims 1
- 210000000845 cartilage Anatomy 0.000 claims 1
- 201000010099 disease Diseases 0.000 claims 1
- 208000035475 disorder Diseases 0.000 claims 1
- 230000002124 endocrine Effects 0.000 claims 1
- 210000005003 heart tissue Anatomy 0.000 claims 1
- 230000000926 neurological effect Effects 0.000 claims 1
- 102000040430 polynucleotide Human genes 0.000 claims 1
- 108091033319 polynucleotide Proteins 0.000 claims 1
- 239000002157 polynucleotide Substances 0.000 claims 1
- 210000002027 skeletal muscle Anatomy 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US15506609P | 2009-02-24 | 2009-02-24 | |
| US61/155,066 | 2009-02-24 | ||
| PCT/US2010/025260 WO2010099219A2 (en) | 2009-02-24 | 2010-02-24 | Designer ligands of tgf-beta superfamily |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2012518420A JP2012518420A (ja) | 2012-08-16 |
| JP2012518420A5 true JP2012518420A5 (enExample) | 2013-04-04 |
| JP5841845B2 JP5841845B2 (ja) | 2016-01-13 |
Family
ID=42666199
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011551315A Active JP5841845B2 (ja) | 2009-02-24 | 2010-02-24 | ＴＧＦ−βスーパーファミリーのデザイナーリガンド |
Country Status (6)
| Country | Link |
|---|---|
| US (2) | US8952130B2 (enExample) |
| EP (1) | EP2401293B1 (enExample) |
| JP (1) | JP5841845B2 (enExample) |
| KR (1) | KR101558642B1 (enExample) |
| CA (1) | CA2752647A1 (enExample) |
| WO (1) | WO2010099219A2 (enExample) |
Families Citing this family (33)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9688735B2 (en) * | 2010-08-20 | 2017-06-27 | Wyeth Llc | Designer osteogenic proteins |
| CN103079585B (zh) | 2010-08-20 | 2015-09-30 | 惠氏有限责任公司 | 经设计的成骨蛋白 |
| JP6254146B2 (ja) * | 2012-03-27 | 2017-12-27 | エヌジーエム バイオファーマシューティカルス，インコーポレーテッド | 代謝障害を治療するための組成物および方法 |
| KR101993714B1 (ko) | 2013-01-30 | 2019-06-28 | 엔지엠 바이오파마슈티컬스, 아이엔씨. | 대사 장애를 치료하는데 이용하기 위한 조성물과 방법 |
| US9161966B2 (en) | 2013-01-30 | 2015-10-20 | Ngm Biopharmaceuticals, Inc. | GDF15 mutein polypeptides |
| ES2924479T3 (es) | 2013-04-08 | 2022-10-07 | Harvard College | Composiciones para rejuvenecer las células madre del músculo esquelético |
| EP3881859B1 (en) * | 2013-06-11 | 2024-03-06 | President and Fellows of Harvard College | Compositions for increasing neurogenesis and angiogenesis |
| US20160287667A1 (en) * | 2013-11-08 | 2016-10-06 | President And Fellows Of Harvard College | Methods and compositions for rejuvenating neuromuscular junctions |
| UA123432C2 (uk) | 2014-07-30 | 2021-04-07 | Нджм Біофармасьютікалз, Інк. | Димер та спосіб його застосування для лікування метаболічних розладів |
| EP3210144B1 (en) * | 2014-10-24 | 2020-10-21 | Koninklijke Philips N.V. | Medical prognosis and prediction of treatment response using multiple cellular signaling pathway activities |
| MD20170035A2 (ro) | 2014-10-31 | 2017-09-30 | Ngm Biopharmaceuticals Inc | Compoziţii şi metode de utilizare pentru tratamentul tulburărilor metabolice |
| EP3215175A4 (en) | 2014-11-06 | 2018-06-27 | Scholar Rock, Inc. | Anti-pro/latent-myostatin antibodies and uses thereof |
| AU2015374114B2 (en) | 2014-12-29 | 2018-07-26 | Bioventus, Llc | Systems and methods for improved delivery of osteoinductive molecules in bone repair |
| AU2016297248A1 (en) * | 2015-07-22 | 2018-02-15 | Scholar Rock, Inc. | GDF11 binding proteins and uses thereof |
| US20200231652A1 (en) | 2015-08-31 | 2020-07-23 | National Research Council Of Canada | Tgf-b-receptor ectodomain fusion molecules and uses thereof |
| IL305148A (en) | 2015-09-15 | 2023-10-01 | Scholar Rock Inc | Anti-pro/hidden myostatin antibodies and their uses |
| CN116059320A (zh) | 2016-01-06 | 2023-05-05 | 哈佛学院校长同事会 | 使用gdf11的治疗防止体重增加、提高葡萄糖耐量并减轻脂肪肝 |
| JP2019504064A (ja) | 2016-01-08 | 2019-02-14 | スカラー ロック インコーポレイテッドＳｃｈｏｌａｒ Ｒｏｃｋ，Ｉｎｃ． | 抗プロ／潜在型ミオスタチン抗体およびその使用方法 |
| CN117986363A (zh) | 2016-03-31 | 2024-05-07 | 恩格姆生物制药公司 | 结合蛋白及其使用方法 |
| WO2017209523A1 (en) * | 2016-05-31 | 2017-12-07 | Mogam Institute For Biomedical Research | Composition comprising an ab6 family designer ligand of tgf-beta superfamily for treating bone and cartilage disease and use thereof |
| US11512126B2 (en) * | 2016-05-31 | 2022-11-29 | Mogam Institute For Biomedicak Research | AB6 family designer ligands of TGF-β superfamily |
| WO2017209522A1 (en) * | 2016-05-31 | 2017-12-07 | Mogam Institute For Biomedical Research | Composition comprising an ab6 family designer ligand of tgf-beta superfamily for treating liver disease and use thereof |
| EP3785728A3 (en) | 2016-06-13 | 2021-04-28 | Scholar Rock, Inc. | Use of myostatin inhibitors and combination therapies |
| AU2017385096B2 (en) | 2016-12-30 | 2021-07-29 | Biogend Therapeutics Co., Ltd. | Recombinant polypeptides and nucleic acid molecules, compositions, and methods of making and uses thereof |
| JP7198757B2 (ja) | 2017-01-06 | 2023-01-04 | スカラー ロック インコーポレイテッド | ミオスタチン活性化の阻害により代謝疾患を処置するための方法 |
| US11261225B2 (en) | 2017-02-10 | 2022-03-01 | Institute For Cancer Research | Chimera of bone morphogenic protein 2 and the Müllerian-inhibiting substance type II receptor binding region of Müllerian-inhibiting substance |
| JP7231553B2 (ja) | 2017-03-02 | 2023-03-01 | ナショナル リサーチ カウンシル オブ カナダ | Ｔｇｆ－ｂ－受容体外部ドメイン融合分子及びその使用 |
| EP3880695A4 (en) * | 2018-11-15 | 2022-01-19 | Joint Center For Biosciences | ACTIVIN/BMP7 CHIMERAS: SUPERACTIVE SAB704 AND SAB715, AND THEIR RESPECTIVE NOGGINE-SENSITIZED VARIANTS, NAB704 AND NAB715; AND NAB204 |
| TW202130655A (zh) | 2019-10-23 | 2021-08-16 | 美商庫爾生物製藥有限公司 | ＴＧＦ—β多肽 |
| WO2022109399A1 (en) * | 2020-11-23 | 2022-05-27 | Cue Biopharma, Inc. | Tgf-beta polypeptides |
| AU2023210700A1 (en) | 2022-01-28 | 2024-08-15 | 35Pharma Inc. | Activin receptor type iib variants and uses thereof |
| CN120677175A (zh) | 2022-12-22 | 2025-09-19 | 供石公司 | 肌生成抑制蛋白活化的选择性和强效抑制剂 |
| EP4653010A1 (en) | 2024-05-14 | 2025-11-26 | 35Pharma Inc. | Activin receptor type iib traps for use in improving body composition |
Family Cites Families (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0272253A4 (en) | 1986-03-07 | 1990-02-05 | Massachusetts Inst Technology | METHOD FOR IMPROVING GLYCOPROTE INSTABILITY. |
| US5108922A (en) * | 1986-07-01 | 1992-04-28 | Genetics Institute, Inc. | DNA sequences encoding BMP-1 products |
| US4877864A (en) * | 1987-03-26 | 1989-10-31 | Genetics Institute, Inc. | Osteoinductive factors |
| ZA874681B (en) * | 1986-07-01 | 1988-04-27 | Genetics Inst | Novel osteoinductive factors |
| US5106748A (en) * | 1986-07-01 | 1992-04-21 | Genetics Institute, Inc. | Dna sequences encoding 5 proteins |
| US5013649A (en) * | 1986-07-01 | 1991-05-07 | Genetics Institute, Inc. | DNA sequences encoding osteoinductive products |
| US5155058A (en) * | 1986-11-07 | 1992-10-13 | Canon Kabushiki Kaisha | Method of making semiconductor memory device |
| US5080891A (en) * | 1987-08-03 | 1992-01-14 | Ddi Pharmaceuticals, Inc. | Conjugates of superoxide dismutase coupled to high molecular weight polyalkylene glycols |
| ATE167486T1 (de) | 1989-10-17 | 1998-07-15 | Stryker Corp | Osteogene vorrichtungen |
| WO1992007004A1 (en) | 1990-10-18 | 1992-04-30 | Creative Biomolecules, Inc. | Osteogenic protein |
| US5677196A (en) * | 1993-05-18 | 1997-10-14 | University Of Utah Research Foundation | Apparatus and methods for multi-analyte homogeneous fluoro-immunoassays |
| US6333168B1 (en) * | 1993-05-20 | 2001-12-25 | The Trustees Of Columbia University In The City Of New York | Cloning, expression and uses of dorsalin-1 |
| US5814565A (en) | 1995-02-23 | 1998-09-29 | University Of Utah Research Foundation | Integrated optic waveguide immunosensor |
| EP1007673B1 (en) | 1997-07-30 | 2008-12-17 | Emory University | Novel bone mineralization proteins, dna, vectors, expression systems |
| US6846906B1 (en) * | 1998-10-07 | 2005-01-25 | Stryker Corporation | Modified proteins of the TGF-β superfamily, including morphogenic proteins |
| US6677432B1 (en) | 1998-10-07 | 2004-01-13 | Stryker Corporation | Mutations of the C-terminal portion of TGF-β superfamily proteins |
| US20090042780A1 (en) | 2004-05-20 | 2009-02-12 | Acceleron Pharma Inc | Modified TGF-Beta Superfamily Polypeptides and Related Methods |
| WO2006047728A2 (en) | 2004-10-27 | 2006-05-04 | New York Society For The Ruptured And Crippled Maintaining The Hospital For Special Surgery | Bmp gene and fusion protein |
-
2010
- 2010-02-24 KR KR1020117021911A patent/KR101558642B1/ko active Active
- 2010-02-24 JP JP2011551315A patent/JP5841845B2/ja active Active
- 2010-02-24 US US12/712,069 patent/US8952130B2/en active Active
- 2010-02-24 WO PCT/US2010/025260 patent/WO2010099219A2/en not_active Ceased
- 2010-02-24 CA CA2752647A patent/CA2752647A1/en active Pending
- 2010-02-24 EP EP10746779.7A patent/EP2401293B1/en active Active
-
2014
- 2014-12-30 US US14/586,573 patent/US20150239950A1/en not_active Abandoned
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