JP2012518420A5 - - Google Patents
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- Publication number
- JP2012518420A5 JP2012518420A5 JP2011551315A JP2011551315A JP2012518420A5 JP 2012518420 A5 JP2012518420 A5 JP 2012518420A5 JP 2011551315 A JP2011551315 A JP 2011551315A JP 2011551315 A JP2011551315 A JP 2011551315A JP 2012518420 A5 JP2012518420 A5 JP 2012518420A5
- Authority
- JP
- Japan
- Prior art keywords
- seq
- amino acid
- residue
- polypeptide
- recombinant polypeptide
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 229920001184 polypeptide Polymers 0.000 claims 18
- 102000004196 processed proteins & peptides Human genes 0.000 claims 18
- 108090000765 processed proteins & peptides Proteins 0.000 claims 18
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 11
- 125000000539 amino acid group Chemical group 0.000 claims 10
- 125000003275 alpha amino acid group Chemical group 0.000 claims 5
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 2
- 210000001519 tissue Anatomy 0.000 claims 2
- 210000000988 bone and bone Anatomy 0.000 claims 1
- 210000000845 cartilage Anatomy 0.000 claims 1
- 201000010099 disease Diseases 0.000 claims 1
- 208000035475 disorder Diseases 0.000 claims 1
- 230000002124 endocrine Effects 0.000 claims 1
- 210000005003 heart tissue Anatomy 0.000 claims 1
- 230000000926 neurological effect Effects 0.000 claims 1
- 102000040430 polynucleotide Human genes 0.000 claims 1
- 108091033319 polynucleotide Proteins 0.000 claims 1
- 239000002157 polynucleotide Substances 0.000 claims 1
- 210000002027 skeletal muscle Anatomy 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US15506609P | 2009-02-24 | 2009-02-24 | |
| US61/155,066 | 2009-02-24 | ||
| PCT/US2010/025260 WO2010099219A2 (en) | 2009-02-24 | 2010-02-24 | Designer ligands of tgf-beta superfamily |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2012518420A JP2012518420A (ja) | 2012-08-16 |
| JP2012518420A5 true JP2012518420A5 (enExample) | 2013-04-04 |
| JP5841845B2 JP5841845B2 (ja) | 2016-01-13 |
Family
ID=42666199
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011551315A Active JP5841845B2 (ja) | 2009-02-24 | 2010-02-24 | ＴＧＦ−βスーパーファミリーのデザイナーリガンド |
Country Status (6)
| Country | Link |
|---|---|
| US (2) | US8952130B2 (enExample) |
| EP (1) | EP2401293B1 (enExample) |
| JP (1) | JP5841845B2 (enExample) |
| KR (1) | KR101558642B1 (enExample) |
| CA (1) | CA2752647A1 (enExample) |
| WO (1) | WO2010099219A2 (enExample) |
Families Citing this family (33)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9688735B2 (en) * | 2010-08-20 | 2017-06-27 | Wyeth Llc | Designer osteogenic proteins |
| KR101630501B1 (ko) | 2010-08-20 | 2016-06-15 | 와이어쓰 엘엘씨 | 디자이너 골형성 단백질 |
| CA2862516C (en) | 2012-03-27 | 2023-02-14 | Ngm Biopharmaceuticals, Inc. | Compositions and methods of use for treating metabolic disorders |
| US9161966B2 (en) | 2013-01-30 | 2015-10-20 | Ngm Biopharmaceuticals, Inc. | GDF15 mutein polypeptides |
| JP6272907B2 (ja) * | 2013-01-30 | 2018-01-31 | エヌジーエム バイオファーマシューティカルズ インコーポレイテッド | 代謝障害の処置における組成物及び使用方法 |
| JP2016518357A (ja) | 2013-04-08 | 2016-06-23 | プレジデント アンド フェローズ オブ ハーバード カレッジ | 骨格筋幹細胞を若返らせる方法および組成物 |
| EP3007719B1 (en) * | 2013-06-11 | 2021-03-17 | President and Fellows of Harvard College | Methods and compositions for increasing neurogenesis and angiogenesis |
| US20160287667A1 (en) * | 2013-11-08 | 2016-10-06 | President And Fellows Of Harvard College | Methods and compositions for rejuvenating neuromuscular junctions |
| TWI710570B (zh) | 2014-07-30 | 2020-11-21 | 美商Ｎｇｍ生物製藥公司 | 用於治療代謝異常之組成物及方法 |
| EP3210144B1 (en) * | 2014-10-24 | 2020-10-21 | Koninklijke Philips N.V. | Medical prognosis and prediction of treatment response using multiple cellular signaling pathway activities |
| AP2017009828A0 (en) | 2014-10-31 | 2017-03-31 | Ngm Biopharmaceuticals Inc | Compositions and methods of use for treating metabolic disorders |
| EP3215175A4 (en) | 2014-11-06 | 2018-06-27 | Scholar Rock, Inc. | Anti-pro/latent-myostatin antibodies and uses thereof |
| CA2977625A1 (en) | 2014-12-29 | 2016-07-07 | Bioventus, Llc | Systems and methods for improved delivery of osteoinductive molecules in bone repair |
| EP3324996A4 (en) * | 2015-07-22 | 2019-04-17 | Scholar Rock, Inc. | GDF11 BINDING PROTEINS AND USES THEREOF |
| WO2017037634A1 (en) | 2015-08-31 | 2017-03-09 | National Research Council Of Canada | Tgf-β-receptor ectodomain fusion molecules and uses thereof |
| PL3350220T3 (pl) | 2015-09-15 | 2022-01-03 | Scholar Rock, Inc. | Przeciwciała przeciwko pro/latentnej miostatynie i ich zastosowania |
| JP6948331B2 (ja) | 2016-01-06 | 2021-10-13 | プレジデント アンド フェローズ オブ ハーバード カレッジ | Ｇｄｆ１１での処置は、体重増加を防止し、耐糖能を改善し、そして脂肪肝を低減する |
| AU2017206069A1 (en) | 2016-01-08 | 2018-07-19 | Scholar Rock, Inc. | Anti-pro/latent myostatin antibodies and methods of use thereof |
| SG11201807279QA (en) | 2016-03-31 | 2018-09-27 | Ngm Biopharmaceuticals Inc | Binding proteins and methods of use thereof |
| KR20190005240A (ko) * | 2016-05-31 | 2019-01-15 | 재단법인 목암생명과학연구소 | Tgf-베타 슈퍼패밀리의 ab6 패밀리 디자이너 리간드를 포함하는 골 및 연골 질환 치료용 조성물 및 그의 이용 |
| US20190135885A1 (en) * | 2016-05-31 | 2019-05-09 | Mogam Institute For Biomedical Research | Composition comprising an ab6 family designer ligand of tgf-beta superfamily for treating liver disease and use thereof |
| US11512126B2 (en) * | 2016-05-31 | 2022-11-29 | Mogam Institute For Biomedicak Research | AB6 family designer ligands of TGF-β superfamily |
| PT3368069T (pt) | 2016-06-13 | 2020-11-11 | Scholar Rock Inc | Uso de inibidores da miostatina e terapias de combinação |
| CA3048735A1 (en) | 2016-12-30 | 2018-07-05 | Biogend Therapeutics Co., Ltd. | Recombinant polypeptides, compositions, and methods thereof |
| SI3565592T1 (sl) | 2017-01-06 | 2023-05-31 | Scholar Rock, Inc. | Zdravljenje presnovnih bolezni z zaviranjem aktivacije miostatina |
| US11261225B2 (en) | 2017-02-10 | 2022-03-01 | Institute For Cancer Research | Chimera of bone morphogenic protein 2 and the Müllerian-inhibiting substance type II receptor binding region of Müllerian-inhibiting substance |
| CN118255902A (zh) | 2017-03-02 | 2024-06-28 | 加拿大国家研究委员会 | TGF-β受体胞外域融合分子及其用途 |
| CN113039199B (zh) * | 2018-11-15 | 2025-03-14 | Osr控股有限公司 | 激活素/骨成型蛋白7嵌合体：超级活性sab704及sab715及作为它们的头蛋白-致敏变体的nab704、nab715及nab204 |
| WO2021081258A1 (en) | 2019-10-23 | 2021-04-29 | Cue Biopharma, Inc. | TGF-β POLYPEPTIDES |
| WO2022109399A1 (en) * | 2020-11-23 | 2022-05-27 | Cue Biopharma, Inc. | Tgf-beta polypeptides |
| KR20240150761A (ko) | 2022-01-28 | 2024-10-16 | 35파마 인크. | 액티빈 수용체 유형 iib 변이체 및 이의 용도 |
| KR20250122524A (ko) | 2022-12-22 | 2025-08-13 | 스칼러 락, 인크. | 미오스타틴 활성화의 선택적이고 강력한 억제 항체 |
| EP4653010A1 (en) | 2024-05-14 | 2025-11-26 | 35Pharma Inc. | Activin receptor type iib traps for use in improving body composition |
Family Cites Families (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS63502716A (ja) | 1986-03-07 | 1988-10-13 | マサチューセッツ・インステチュート・オブ・テクノロジー | 糖タンパク安定性の強化方法 |
| US5013649A (en) | 1986-07-01 | 1991-05-07 | Genetics Institute, Inc. | DNA sequences encoding osteoinductive products |
| US5106748A (en) | 1986-07-01 | 1992-04-21 | Genetics Institute, Inc. | Dna sequences encoding 5 proteins |
| US5108922A (en) | 1986-07-01 | 1992-04-28 | Genetics Institute, Inc. | DNA sequences encoding BMP-1 products |
| US4877864A (en) | 1987-03-26 | 1989-10-31 | Genetics Institute, Inc. | Osteoinductive factors |
| ZA874681B (en) | 1986-07-01 | 1988-04-27 | Genetics Inst | Novel osteoinductive factors |
| US5155058A (en) | 1986-11-07 | 1992-10-13 | Canon Kabushiki Kaisha | Method of making semiconductor memory device |
| US5080891A (en) | 1987-08-03 | 1992-01-14 | Ddi Pharmaceuticals, Inc. | Conjugates of superoxide dismutase coupled to high molecular weight polyalkylene glycols |
| JP2845346B2 (ja) | 1989-10-17 | 1999-01-13 | ストライカー・コーポレーション | 骨形成具 |
| WO1992007004A1 (en) | 1990-10-18 | 1992-04-30 | Creative Biomolecules, Inc. | Osteogenic protein |
| US5677196A (en) | 1993-05-18 | 1997-10-14 | University Of Utah Research Foundation | Apparatus and methods for multi-analyte homogeneous fluoro-immunoassays |
| US6333168B1 (en) * | 1993-05-20 | 2001-12-25 | The Trustees Of Columbia University In The City Of New York | Cloning, expression and uses of dorsalin-1 |
| US5814565A (en) | 1995-02-23 | 1998-09-29 | University Of Utah Research Foundation | Integrated optic waveguide immunosensor |
| CA2297489A1 (en) | 1997-07-30 | 1999-02-11 | Emory University | Novel bone mineralization proteins, dna, vectors, expression systems |
| US6846906B1 (en) * | 1998-10-07 | 2005-01-25 | Stryker Corporation | Modified proteins of the TGF-β superfamily, including morphogenic proteins |
| US6677432B1 (en) | 1998-10-07 | 2004-01-13 | Stryker Corporation | Mutations of the C-terminal portion of TGF-β superfamily proteins |
| US20090042780A1 (en) * | 2004-05-20 | 2009-02-12 | Acceleron Pharma Inc | Modified TGF-Beta Superfamily Polypeptides and Related Methods |
| US20090202638A2 (en) | 2004-10-27 | 2009-08-13 | New York Society For The Ruptured And Crippled Maintaining The Hospital For Special Surgery | Bmp gene and fusion protein |
-
2010
- 2010-02-24 CA CA2752647A patent/CA2752647A1/en active Pending
- 2010-02-24 US US12/712,069 patent/US8952130B2/en active Active
- 2010-02-24 EP EP10746779.7A patent/EP2401293B1/en active Active
- 2010-02-24 WO PCT/US2010/025260 patent/WO2010099219A2/en not_active Ceased
- 2010-02-24 JP JP2011551315A patent/JP5841845B2/ja active Active
- 2010-02-24 KR KR1020117021911A patent/KR101558642B1/ko active Active
-
2014
- 2014-12-30 US US14/586,573 patent/US20150239950A1/en not_active Abandoned
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