ATE167486T1 - Osteogene vorrichtungen - Google Patents
Osteogene vorrichtungenInfo
- Publication number
- ATE167486T1 ATE167486T1 AT90916655T AT90916655T ATE167486T1 AT E167486 T1 ATE167486 T1 AT E167486T1 AT 90916655 T AT90916655 T AT 90916655T AT 90916655 T AT90916655 T AT 90916655T AT E167486 T1 ATE167486 T1 AT E167486T1
- Authority
- AT
- Austria
- Prior art keywords
- osteogenic
- devices
- osteogenic devices
- protein
- mimic
- Prior art date
Links
- 230000002188 osteogenic effect Effects 0.000 title abstract 6
- 102000004169 proteins and genes Human genes 0.000 abstract 3
- 108090000623 proteins and genes Proteins 0.000 abstract 3
- 102000008186 Collagen Human genes 0.000 abstract 1
- 108010035532 Collagen Proteins 0.000 abstract 1
- 241000124008 Mammalia Species 0.000 abstract 1
- 108020004511 Recombinant DNA Proteins 0.000 abstract 1
- 125000003275 alpha amino acid group Chemical group 0.000 abstract 1
- 210000000988 bone and bone Anatomy 0.000 abstract 1
- 229920001436 collagen Polymers 0.000 abstract 1
- 230000035194 endochondral ossification Effects 0.000 abstract 1
- 239000011159 matrix material Substances 0.000 abstract 1
- 230000003278 mimic effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/475—Growth factors; Growth regulators
- C07K14/51—Bone morphogenetic factor; Osteogenins; Osteogenic factor; Bone-inducing factor
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/14—Macromolecular materials
- A61L27/22—Polypeptides or derivatives thereof, e.g. degradation products
- A61L27/227—Other specific proteins or polypeptides not covered by A61L27/222, A61L27/225 or A61L27/24
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/14—Macromolecular materials
- A61L27/22—Polypeptides or derivatives thereof, e.g. degradation products
- A61L27/24—Collagen
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/28—Materials for coating prostheses
- A61L27/34—Macromolecular materials
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
- A61L27/3604—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix characterised by the human or animal origin of the biological material, e.g. hair, fascia, fish scales, silk, shellac, pericardium, pleura, renal tissue, amniotic membrane, parenchymal tissue, fetal tissue, muscle tissue, fat tissue, enamel
- A61L27/3608—Bone, e.g. demineralised bone matrix [DBM], bone powder
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61C—DENTISTRY; APPARATUS OR METHODS FOR ORAL OR DENTAL HYGIENE
- A61C8/00—Means to be fixed to the jaw-bone for consolidating natural teeth or for fixing dental prostheses thereon; Dental implants; Implanting tools
- A61C8/0003—Not used, see subgroups
- A61C8/0004—Consolidating natural teeth
- A61C8/0006—Periodontal tissue or bone regeneration
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2310/00—Prostheses classified in A61F2/28 or A61F2/30 - A61F2/44 being constructed from or coated with a particular material
- A61F2310/00005—The prosthesis being constructed from a particular material
- A61F2310/00365—Proteins; Polypeptides; Degradation products thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2430/00—Materials or treatment for tissue regeneration
- A61L2430/02—Materials or treatment for tissue regeneration for reconstruction of bones; weight-bearing implants
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Transplantation (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Organic Chemistry (AREA)
- Dermatology (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Biomedical Technology (AREA)
- Molecular Biology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Zoology (AREA)
- Biophysics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Urology & Nephrology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Toxicology (AREA)
- Gastroenterology & Hepatology (AREA)
- Biochemistry (AREA)
- Botany (AREA)
- Genetics & Genomics (AREA)
- Physical Education & Sports Medicine (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Materials For Medical Uses (AREA)
- Separation By Low-Temperature Treatments (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Prostheses (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US42269989A | 1989-10-17 | 1989-10-17 | |
| US07/483,913 US5171574A (en) | 1989-02-23 | 1990-02-22 | Bone collagen matrix for implants |
| US56992090A | 1990-08-20 | 1990-08-20 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE167486T1 true ATE167486T1 (de) | 1998-07-15 |
Family
ID=27411374
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT90916655T ATE167486T1 (de) | 1989-10-17 | 1990-10-15 | Osteogene vorrichtungen |
Country Status (11)
| Country | Link |
|---|---|
| EP (1) | EP0448704B1 (de) |
| JP (6) | JP2845346B2 (de) |
| AT (1) | ATE167486T1 (de) |
| CA (1) | CA2042577A1 (de) |
| DE (1) | DE69032424T2 (de) |
| DK (1) | DK0448704T3 (de) |
| ES (1) | ES2118723T3 (de) |
| GR (1) | GR3027722T3 (de) |
| LU (1) | LU90855I2 (de) |
| NL (1) | NL300062I2 (de) |
| WO (1) | WO1991005802A1 (de) |
Families Citing this family (64)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5459047A (en) | 1986-07-01 | 1995-10-17 | Genetics Institute, Inc. | BMP-6 proteins |
| US5939388A (en) * | 1986-07-01 | 1999-08-17 | Rosen; Vicki A. | Methods of administering BMP-5 compositions |
| US6150328A (en) * | 1986-07-01 | 2000-11-21 | Genetics Institute, Inc. | BMP products |
| US6432919B1 (en) | 1986-07-01 | 2002-08-13 | Genetics Institute, Inc. | Bone morphogenetic protein-3 and compositions |
| US5187076A (en) * | 1986-07-01 | 1993-02-16 | Genetics Institute, Inc. | DNA sequences encoding BMP-6 proteins |
| US5366875A (en) * | 1986-07-01 | 1994-11-22 | Genetics Institute, Inc. | Methods for producing BMP-7 proteins |
| US5543394A (en) * | 1986-07-01 | 1996-08-06 | Genetics Institute, Inc. | Bone morphogenetic protein 5(BMP-5) compositions |
| US5013649A (en) * | 1986-07-01 | 1991-05-07 | Genetics Institute, Inc. | DNA sequences encoding osteoinductive products |
| US5344654A (en) * | 1988-04-08 | 1994-09-06 | Stryker Corporation | Prosthetic devices having enhanced osteogenic properties |
| US5284756A (en) * | 1988-10-11 | 1994-02-08 | Lynn Grinna | Heterodimeric osteogenic factor |
| ES2113857T3 (es) * | 1989-03-28 | 1998-05-16 | Genetics Inst | Composiciones osteoinductoras. |
| US5688678A (en) * | 1990-05-16 | 1997-11-18 | Genetics Institute, Inc. | DNA encoding and methods for producing BMP-8 proteins |
| US7378392B1 (en) | 1990-05-16 | 2008-05-27 | Genetics Institute, Llc | Bone and cartilage inductive proteins |
| US5739107A (en) | 1991-03-11 | 1998-04-14 | Creative Biomolecules, Inc. | Morphogen treatment of gastrointestinal ulcers |
| US6194376B1 (en) | 1991-03-11 | 2001-02-27 | Creative Biomolecules, Inc. | Method for modulating inflammatory response comprising administering morphogen |
| AU660019B2 (en) * | 1991-03-11 | 1995-06-08 | Stryker Corporation | Protein-induced morphogenesis |
| US7056882B2 (en) | 1991-03-11 | 2006-06-06 | Curis, Inc. | Treatment to prevent loss of and/or increase bone mass in metabolic bone diseases |
| US6395883B1 (en) | 1991-03-11 | 2002-05-28 | Curis, Inc. | Soluble morphogenic protein complex compositions of matter |
| US6090776A (en) * | 1991-03-11 | 2000-07-18 | Creative Bio Molecules, Inc. | Morphogen treatment of organ implants |
| CA2363965C (en) | 1991-03-11 | 2010-05-18 | Curis, Inc. | Protein-induced morphogenesis |
| US5674844A (en) * | 1991-03-11 | 1997-10-07 | Creative Biomolecules, Inc. | Treatment to prevent loss of and/or increase bone mass in metabolic bone diseases |
| US6077823A (en) * | 1991-03-11 | 2000-06-20 | Creative Biomolecules, Inc. | Method for reducing tissue damage associated with ischemia-reperfusion or hypoxia injury |
| US6287816B1 (en) | 1991-06-25 | 2001-09-11 | Genetics Institute, Inc. | BMP-9 compositions |
| KR100255415B1 (ko) * | 1991-06-25 | 2000-05-01 | 브루스 엠. 에이센 | 비엠피-9 조성물 |
| DE69233559T2 (de) * | 1991-08-30 | 2006-08-31 | Curis, Inc., Cambridge | Osteogenische proteine in der behandlung von metabolischen knochenkrankheiten |
| CA2116562C (en) * | 1991-08-30 | 1999-04-13 | Thangavel Kuberasampath | Morphogen-induced modulation of inflammatory response |
| US5171579A (en) * | 1991-10-11 | 1992-12-15 | Genetics Institute, Inc. | Formulations of blood clot-polymer matrix for delivery of osteogenic proteins |
| DE69233022T2 (de) | 1991-11-04 | 2004-02-12 | Genetics Institute, LLC, Cambridge | Rekombinante knochenmorphogenetische protein heterodimere, zusammensetzungen und verfahren zur verwendung |
| IT1259042B (it) * | 1992-01-27 | 1996-03-11 | Mini Ricerca Scient Tecnolog | Preparazione di vettori di espressione per la sintesi del polipeptide chiamato fattore osteogenetico op-1 in cellule eucariotiche di spodoptera frugiperda via infezione con baculovirus ricombinante |
| HU218845B (hu) * | 1992-02-12 | 2000-12-28 | Biopharm Gesellschaft Zur Biotechnologischen Entwicklung Von Pharmaka Mbh. | Új növekedési/differenciáló faktorokat kódoló DNS-szekvenciák, e faktorokat tartalmazó gyógyszerkészítmények, DNS-molekulák, gazdaszervezetek, antitestek, diagnosztikai eljárások |
| US6764994B1 (en) | 1993-08-10 | 2004-07-20 | Biopharm Gesellschaft Zur Biotechnologischen Entwicklung Von Pharmaka Mbh | Growth/differential factor of the TGF-B family |
| IL110589A0 (en) * | 1993-08-10 | 1994-11-11 | Bioph Biotech Entw Pharm Gmbh | Growth/differentiation factor of the TGF- beta family |
| US6291206B1 (en) | 1993-09-17 | 2001-09-18 | Genetics Institute, Inc. | BMP receptor proteins |
| US5631159A (en) * | 1993-09-22 | 1997-05-20 | Creative Biomolecules, Inc. | Lipid-modified serum free media |
| DE69434651T2 (de) | 1993-12-07 | 2007-03-08 | Genetics Institute, Inc., Cambridge | Bmp-12, bmp-13 und diese enthaltende sehne-induzierende zusammensetzungen |
| ATE378407T1 (de) | 1994-04-29 | 2007-11-15 | Curis Inc | Morphogene protein-spezifische zelloberflächenrezeptoren und ihre verwendungen |
| US5906827A (en) * | 1994-06-03 | 1999-05-25 | Creative Biomolecules, Inc. | Matrix for the manufacture of autogenous replacement body parts |
| US6040431A (en) * | 1995-06-07 | 2000-03-21 | Stryker Corporation | Single chain analogs of the TGF-β superfamily (morphons) |
| DE69723429T3 (de) | 1996-03-22 | 2007-09-20 | Curis, Inc., Cambridge | Verfahren zur verbesserten funktionellen Erholung der motorischen Koordination, der Sprache oder Sinneswahrnehmung nach Trauma oder Ischämie des ZNS |
| US6492508B1 (en) | 1996-06-03 | 2002-12-10 | United States Surgical Corp. A Division Of Tyco Healthcare Group | Nucleic acids encoding extracellular matrix proteins |
| DE19647853A1 (de) | 1996-11-19 | 1998-05-20 | Bioph Biotech Entw Pharm Gmbh | Verbindungen mit verbesserter knorpel- und/oder knocheninduzierender Aktivität |
| US6034062A (en) * | 1997-03-13 | 2000-03-07 | Genetics Institute, Inc. | Bone morphogenetic protein (BMP)-9 compositions and their uses |
| CA2291514C (en) * | 1997-05-30 | 2011-07-12 | Mariel Therapeutics, Inc. | Methods for evaluating tissue morphogenesis and activity |
| EP1037910A2 (de) * | 1997-12-04 | 2000-09-27 | Curis, Inc. | Nachschutz der glatte muskulatur durch morphogenetische protein |
| AU1103900A (en) | 1998-10-07 | 2000-04-26 | Stryker Corporation | Modified tgf-beta superfamily proteins |
| US6677432B1 (en) | 1998-10-07 | 2004-01-13 | Stryker Corporation | Mutations of the C-terminal portion of TGF-β superfamily proteins |
| US6846906B1 (en) | 1998-10-07 | 2005-01-25 | Stryker Corporation | Modified proteins of the TGF-β superfamily, including morphogenic proteins |
| US6663870B2 (en) | 1998-12-07 | 2003-12-16 | Zymogenetics, Inc. | Methods for promoting growth of bone using zvegf3 |
| US6727224B1 (en) | 1999-02-01 | 2004-04-27 | Genetics Institute, Llc. | Methods and compositions for healing and repair of articular cartilage |
| DE19906096A1 (de) | 1999-02-13 | 2000-08-17 | Walter Sebald | Protein mit einem Heparin-bindenden Epitop |
| US6468543B1 (en) | 1999-05-03 | 2002-10-22 | Zymogenetics, Inc. | Methods for promoting growth of bone using ZVEGF4 |
| ATE271886T1 (de) | 1999-10-15 | 2004-08-15 | Inst Genetics Llc | Hyaluronsäure enthaltende zusammensetzungen zur abgabe osteogener proteine |
| WO2001057083A1 (en) * | 2000-02-04 | 2001-08-09 | Zymogenetics, Inc. | Methods for promoting growth of bone, ligament, and cartilage using zvegf4 |
| WO2002099037A2 (en) | 2001-06-01 | 2002-12-12 | Wyeth | Compositions and methods for systemic administration of sequences encoding bone morphogenetic proteins |
| TWI267378B (en) | 2001-06-08 | 2006-12-01 | Wyeth Corp | Calcium phosphate delivery vehicles for osteoinductive proteins |
| WO2003030925A1 (fr) * | 2001-10-02 | 2003-04-17 | Kiyoshi Nokihara | Medicaments d'angiogenese |
| SI1448246T2 (sl) | 2001-11-19 | 2015-12-31 | Scil Technology Gmbh | Postopek za proizvodnjo homogeno obložene naprave, ki ima osteoinduktivne in osteokonduktivne lastnosti |
| CN100522241C (zh) | 2002-09-10 | 2009-08-05 | Scil技术股份有限公司 | 在低氧气浓度下用骨诱导蛋白包被的金属植入物 |
| US7163920B2 (en) | 2003-09-30 | 2007-01-16 | Ethicon, Inc. | Peptide with osteogenic activity |
| PL1737734T3 (pl) | 2004-03-10 | 2011-02-28 | Scil Tech Gmbh | Powlekane implanty, ich wytwarzanie i zastosowanie |
| WO2005116052A2 (en) | 2004-04-27 | 2005-12-08 | Research Development Foundation | ANTAGONISM OF TGF-β SUPERFAMILY RECEPTOR SIGNALING |
| DE102008036576A1 (de) * | 2008-07-31 | 2010-02-04 | Gelita Ag | Partikel aus Kollagenmaterial und Verfahren zur Herstellung |
| US8952130B2 (en) | 2009-02-24 | 2015-02-10 | The Salk Institute For Biological Studies | Designer ligands of TGF-β superfamily |
| WO2010144696A1 (en) | 2009-06-11 | 2010-12-16 | Burnham Institute For Medical Research | Directed differentiation of stem cells |
Family Cites Families (28)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4172128A (en) * | 1975-03-26 | 1979-10-23 | Erhard Thiele | Process of degrading and regenerating bone and tooth material and products |
| US4294753A (en) * | 1980-08-04 | 1981-10-13 | The Regents Of The University Of California | Bone morphogenetic protein process |
| US4394370A (en) * | 1981-09-21 | 1983-07-19 | Jefferies Steven R | Bone graft material for osseous defects and method of making same |
| US4434094A (en) * | 1983-04-12 | 1984-02-28 | Collagen Corporation | Partially purified osteogenic factor and process for preparing same from demineralized bone |
| CA1229789A (en) * | 1983-06-06 | 1987-12-01 | David Baylink | Polypeptides exhibiting skeletal growth factor activity |
| US4795804A (en) * | 1983-08-16 | 1989-01-03 | The Regents Of The University Of California | Bone morphogenetic agents |
| NZ210699A (en) * | 1984-01-04 | 1989-06-28 | Int Genetic Eng | Isolation of an osteogenic protein of the p3 immunologically related family |
| US4563489A (en) * | 1984-02-10 | 1986-01-07 | University Of California | Biodegradable organic polymer delivery system for bone morphogenetic protein |
| MX163953B (es) * | 1984-03-27 | 1992-07-03 | Univ New Jersey Med | Procedimiento para preparar una matriz biodegradable a base de colageno |
| US4837285A (en) * | 1984-03-27 | 1989-06-06 | Medimatrix | Collagen matrix beads for soft tissue repair |
| US4620327A (en) * | 1984-07-05 | 1986-11-04 | Caplan Arnold I | Process of adapting soluble bone protein for use in stimulating osteoinduction |
| US4789663A (en) * | 1984-07-06 | 1988-12-06 | Collagen Corporation | Methods of bone repair using collagen |
| EP0169016B2 (de) * | 1984-07-16 | 2004-04-28 | Celtrix Pharmaceuticals, Inc. | Knorpel-induzierende Polypeptid-Faktoren aus Knochen |
| EP0169001A3 (en) * | 1984-07-17 | 1987-11-25 | Collagen Corporation | Collagen coated bone implants |
| US4657548A (en) * | 1984-09-11 | 1987-04-14 | Helitrex, Inc. | Delivery system for implantation of fine particles in surgical procedures |
| US4563350A (en) * | 1984-10-24 | 1986-01-07 | Collagen Corporation | Inductive collagen based bone repair preparations |
| US4888366A (en) * | 1984-10-24 | 1989-12-19 | Collagen Corporation | Inductive collagen-based bone repair preparations |
| US4600533A (en) * | 1984-12-24 | 1986-07-15 | Collagen Corporation | Collagen membranes for medical use |
| ATE87469T1 (de) * | 1985-12-27 | 1993-04-15 | Sumitomo Pharma | Verfahren zur herstellung einer formulierung mit verzoegerter freisetzung. |
| IL83003A (en) * | 1986-07-01 | 1995-07-31 | Genetics Inst | Osteoinductive factors |
| US4824939A (en) * | 1986-10-09 | 1989-04-25 | Eastman Kodak Company | Process for leaching particulate solid materials |
| IT1214505B (it) * | 1987-03-12 | 1990-01-18 | Gentili Ist Spa | Procedimento per la preparazione di collageno e prodotti cosi'ottenuto. |
| JPS6434371A (en) * | 1987-07-31 | 1989-02-03 | Nitta Gelatin Kk | Periosteal bone forming material |
| US4812120A (en) * | 1987-11-02 | 1989-03-14 | Flanagan Dennis F | Implantable percutaneous device |
| WO1989009605A1 (en) * | 1988-04-06 | 1989-10-19 | Collagen Corporation | Bone-inducing protein |
| DE68929472T2 (de) * | 1988-04-08 | 2004-05-13 | Stryker Corp., Kalamazoo | Biosynthetische knochenbildende Proteine, und sie enthaltende knochenbildende Vorrichtungen |
| KR900700617A (ko) * | 1988-04-08 | 1990-08-16 | 브루스 엠. 에이센 | 뼈 및 연골 유도 조성물 |
| ES2113857T3 (es) * | 1989-03-28 | 1998-05-16 | Genetics Inst | Composiciones osteoinductoras. |
-
1990
- 1990-10-15 ES ES90916655T patent/ES2118723T3/es not_active Expired - Lifetime
- 1990-10-15 DK DK90916655T patent/DK0448704T3/da active
- 1990-10-15 AT AT90916655T patent/ATE167486T1/de not_active IP Right Cessation
- 1990-10-15 JP JP2515578A patent/JP2845346B2/ja not_active Expired - Lifetime
- 1990-10-15 CA CA002042577A patent/CA2042577A1/en not_active Abandoned
- 1990-10-15 EP EP90916655A patent/EP0448704B1/de not_active Expired - Lifetime
- 1990-10-15 WO PCT/US1990/005903 patent/WO1991005802A1/en not_active Ceased
- 1990-10-15 DE DE69032424T patent/DE69032424T2/de not_active Expired - Lifetime
-
1997
- 1997-07-02 JP JP9177440A patent/JPH10114673A/ja not_active Withdrawn
-
1998
- 1998-08-26 GR GR980401900T patent/GR3027722T3/el unknown
-
2000
- 2000-08-24 JP JP2000254562A patent/JP3368260B2/ja not_active Expired - Lifetime
-
2001
- 2001-09-27 NL NL300062C patent/NL300062I2/nl unknown
- 2001-11-15 LU LU90855C patent/LU90855I2/en unknown
-
2002
- 2002-01-16 JP JP2002008070A patent/JP2002281976A/ja not_active Withdrawn
-
2003
- 2003-10-07 JP JP2003348890A patent/JP2004041236A/ja not_active Withdrawn
-
2005
- 2005-09-21 JP JP2005274803A patent/JP2006068018A/ja not_active Withdrawn
Also Published As
| Publication number | Publication date |
|---|---|
| JP2002281976A (ja) | 2002-10-02 |
| AU6648190A (en) | 1991-05-16 |
| EP0448704B1 (de) | 1998-06-17 |
| NL300062I1 (nl) | 2001-12-01 |
| DK0448704T3 (da) | 1999-04-06 |
| ES2118723T3 (es) | 1998-10-01 |
| EP0448704A4 (en) | 1992-07-08 |
| JP2845346B2 (ja) | 1999-01-13 |
| CA2042577A1 (en) | 1991-04-18 |
| GR3027722T3 (en) | 1998-11-30 |
| JP3368260B2 (ja) | 2003-01-20 |
| JPH04502336A (ja) | 1992-04-23 |
| JP2004041236A (ja) | 2004-02-12 |
| NL300062I2 (nl) | 2002-02-01 |
| DE69032424D1 (de) | 1998-07-23 |
| WO1991005802A1 (en) | 1991-05-02 |
| DE69032424T2 (de) | 1999-02-04 |
| JP2006068018A (ja) | 2006-03-16 |
| JP2001095591A (ja) | 2001-04-10 |
| AU648997B2 (en) | 1994-05-12 |
| EP0448704A1 (de) | 1991-10-02 |
| JPH10114673A (ja) | 1998-05-06 |
| LU90855I2 (en) | 2002-01-24 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| EELA | Cancelled due to lapse of time |