KR900700617A - 뼈 및 연골 유도 조성물 - Google Patents

뼈 및 연골 유도 조성물

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Publication number
KR900700617A
KR900700617A KR1019890702291A KR890702291A KR900700617A KR 900700617 A KR900700617 A KR 900700617A KR 1019890702291 A KR1019890702291 A KR 1019890702291A KR 890702291 A KR890702291 A KR 890702291A KR 900700617 A KR900700617 A KR 900700617A
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KR
South Korea
Prior art keywords
protein
bone
composition
sequence
effective amount
Prior art date
Application number
KR1019890702291A
Other languages
English (en)
Inventor
엘리자베트 에이. 왕
죤 엠. 워즈니
빅키 로센
Original Assignee
브루스 엠. 에이센
제네틱스 인스티튜트, 인코포레이티드
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 브루스 엠. 에이센, 제네틱스 인스티튜트, 인코포레이티드 filed Critical 브루스 엠. 에이센
Publication of KR900700617A publication Critical patent/KR900700617A/ko

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/14—Macromolecular materials
    • A61L27/22—Polypeptides or derivatives thereof, e.g. degradation products
    • A61L27/227—Other specific proteins or polypeptides not covered by A61L27/222, A61L27/225 or A61L27/24
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475—Growth factors; Growth regulators
    • C07K14/51—Bone morphogenetic factor; Osteogenins; Osteogenic factor; Bone-inducing factor
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biophysics (AREA)
  • Toxicology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Dermatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biochemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Transplantation (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)

Abstract

내용 없음

Description

뼈 및 연골 유도 조성물
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (18)

  1. (a) 실제로 표Ⅱ에 나타나 있는 cDNA로 형질전환시킨 세포를 배양하고 , (b) 상기 배양배지로 부터 표Ⅱ에 나타나 있는 아미노산 번호377 내지 아미노산 번호472의 실제로 %개 아미노산서열을 포함하는 단백질을 회수하는 단계에 의해 제조한 정제된 BMP-3 단백질.
  2. 제1항에 있어서, 연골 및/또는 뼈형성을 유도하는 능력을 갖는 단백질.
  3. 제1항에 있어서, 상기 단백질 1㎍이 로젠-변형된 샘패쓰-레디 시험에서 적어도 C＋2로 평가되는 능력을 갖는 단백질.
  4. 청구범위 제2항의 단백질을 코오딩하는 cDNA 서열.
  5. 청구범위 제4항의 cDNA로 형질전환된 숙주세포.
  6. (a) 청구범위 제5항의 형질전환된 숙주 세포를 적합한 배양 배지내에서 배양하고, (b) 상기 배양배지로부터 BMP-3를 분리 및 정제하는 단계로 이루어진, 정제된 BMP-3 단백질의 제조방법.
  7. 청구범위 제1항의 유효량의 단백질을 약학적으로 허용가능한 부형약과 혼합하여 함유하는 약학 조성물.
  8. 약학적으로 허용 가능한 부형약내에 청구범위 제2항의 유효량의 단백질을 함유하는, 뼈 및/또는 연골형성을 위한 약학 제제.
  9. 제8항에 있어서, 조성물을 지지하며 뼈 및/또는 연골 생장용 표면을 제공하기 위한 기질을 더 함유하는 조성물.
  10. 제9항에 있어서, 기질이 히드록시아파타이트, 콜라겐, 폴리락트산 및 트리칼슘 포스페이트로 이루어진 군으로부터 선택된 물질인 조성물.
  11. 뼈 및/또는 연골형성을 필요로 하는 환자에게 유효량의 청구범위 제8항의 조성물을 투여하는 것을 특징으로 하는, 해당 환자내에서의 뼈 및/또는 연골 형성 유도 방법.
  12. 약학적으로 허용 가능한 부형약내에 유효량의 청구범위 제1항의 단백질을 함유하는 조성물인, 상처 치료 및 조직 재생을 위한 약학 조성물.
  13. 상처 치료 및/또는 조직 재생을 필요로 하는 환자에게 유효량의 청구범위 제12항의 조성물을 투여하는 것을 특징으로 하는, 해당 환자내에서의 상처 치료 및/또는 조직 재생방법.
  14. (a) 누클레오티드 번호 321 내지 누클레오티드 번호 1736의 서열, (b) (1) 엄격한 혼성 조건하에 상기서열에 혼성되며, (2) 연골 및/또는 뼈 형성을 유도하는 능력을 갖는 단백질을 코오딩하는 서열로 이루어진 군으로 부터 선택된 누클레오티드 서열 또는 그 중 일부를 실제로 포함하는, BMP-3단백질을 코오딩하는, 분리된 DNA 서열.
  15. 제14항에 있어서, 상기 단백질 1㎍이 로젠-변형된 샘패쓰-레디 시험에서 적어도 ＋2로 평가되는 능력을 가지는 것을 특징으로 하는 DNA 서열.
  16. 청구범위 제14항의 DNA 서열이 그에 대한 발현 조절 서열과 수행상 연결되어 있는 벡타.
  17. 청구범위 제14항의 DNA 서열로 형질 전환된 숙주 세포.
  18. (a) 청구범위 제17항의 형질 전환된 숙주 세포를 적합한 배양 배지 내에서 배양하고, (b) 상기 배양 배지로 부터 BMP-3를 분리 및 정제하는 단계로 이루어진, BMP-3단백질 제조방법.
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019890702291A 1988-04-08 1989-04-07 뼈 및 연골 유도 조성물 KR900700617A (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US17919788A 1988-04-08 1988-04-08
US179,197 1988-04-08
PCT/US1989/001464 WO1989010409A1 (en) 1988-04-08 1989-04-07 Bone and cartilage inductive compositions

Publications (1)

Publication Number Publication Date
KR900700617A true KR900700617A (ko) 1990-08-16

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ID=22655627

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019890702291A KR900700617A (ko) 1988-04-08 1989-04-07 뼈 및 연골 유도 조성물

Country Status (5)

Country Link
EP (1) EP0408649A4 (ko)
JP (1) JPH03503649A (ko)
KR (1) KR900700617A (ko)
AU (1) AU645244B2 (ko)
WO (1) WO1989010409A1 (ko)

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US5324819A (en) * 1988-04-08 1994-06-28 Stryker Corporation Osteogenic proteins
EP1225225A3 (en) * 1988-04-08 2003-01-08 Stryker Corporation Osteogenic devices
US5258494A (en) 1988-04-08 1993-11-02 Stryker Corporation Osteogenic proteins
US5011691A (en) * 1988-08-15 1991-04-30 Stryker Corporation Osteogenic devices
US5670336A (en) * 1988-04-08 1997-09-23 Stryker Corporation Method for recombinant production of osteogenic protein
US5354557A (en) * 1988-04-08 1994-10-11 Stryker Corporation Osteogenic devices
US6586388B2 (en) 1988-04-08 2003-07-01 Stryker Corporation Method of using recombinant osteogenic protein to repair bone or cartilage defects
US5250302A (en) * 1988-04-08 1993-10-05 Stryker Corporation Osteogenic devices
US5108753A (en) * 1988-04-08 1992-04-28 Creative Biomolecules Osteogenic devices
US5266683A (en) * 1988-04-08 1993-11-30 Stryker Corporation Osteogenic proteins
US5284756A (en) * 1988-10-11 1994-02-08 Lynn Grinna Heterodimeric osteogenic factor
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Also Published As

Publication number Publication date
JPH03503649A (ja) 1991-08-15
AU645244B2 (en) 1994-01-13
EP0408649A4 (en) 1991-11-27
EP0408649A1 (en) 1991-01-23
AU3448789A (en) 1989-11-24
WO1989010409A1 (en) 1989-11-02

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