EP0408649A4 - Bone and cartilage inductive compositions - Google Patents

Bone and cartilage inductive compositions

Info

Publication number
EP0408649A4
EP0408649A4 EP19890904945 EP89904945A EP0408649A4 EP 0408649 A4 EP0408649 A4 EP 0408649A4 EP 19890904945 EP19890904945 EP 19890904945 EP 89904945 A EP89904945 A EP 89904945A EP 0408649 A4 EP0408649 A4 EP 0408649A4
Authority
EP
European Patent Office
Prior art keywords
bone
compositions
cartilage inductive
cartilage
inductive compositions
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
EP19890904945
Other languages
English (en)
Other versions
EP0408649A1 (en
Inventor
Elizabeth A. Wang
John M. Wozney
Vicki Rosen
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Genetics Institute LLC
Original Assignee
Genetics Institute LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Genetics Institute LLC filed Critical Genetics Institute LLC
Publication of EP0408649A1 publication Critical patent/EP0408649A1/en
Publication of EP0408649A4 publication Critical patent/EP0408649A4/en
Ceased legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/14—Macromolecular materials
    • A61L27/22—Polypeptides or derivatives thereof, e.g. degradation products
    • A61L27/227—Other specific proteins or polypeptides not covered by A61L27/222, A61L27/225 or A61L27/24
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475—Growth factors; Growth regulators
    • C07K14/51—Bone morphogenetic factor; Osteogenins; Osteogenic factor; Bone-inducing factor
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biophysics (AREA)
  • Toxicology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Dermatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biochemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Transplantation (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
EP19890904945 1988-04-08 1989-04-07 Bone and cartilage inductive compositions Ceased EP0408649A4 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US17919788A 1988-04-08 1988-04-08
US179197 1988-04-08

Publications (2)

Publication Number Publication Date
EP0408649A1 EP0408649A1 (en) 1991-01-23
EP0408649A4 true EP0408649A4 (en) 1991-11-27

Family

ID=22655627

Family Applications (1)

Application Number Title Priority Date Filing Date
EP19890904945 Ceased EP0408649A4 (en) 1988-04-08 1989-04-07 Bone and cartilage inductive compositions

Country Status (5)

Country Link
EP (1) EP0408649A4 (ko)
JP (1) JPH03503649A (ko)
KR (1) KR900700617A (ko)
AU (1) AU645244B2 (ko)
WO (1) WO1989010409A1 (ko)

Families Citing this family (45)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4968590A (en) * 1988-04-08 1990-11-06 Stryker Corporation Osteogenic proteins and polypeptides
US6919308B2 (en) 1988-04-08 2005-07-19 Stryker Corporation Osteogenic devices
US5324819A (en) * 1988-04-08 1994-06-28 Stryker Corporation Osteogenic proteins
EP1225225A3 (en) * 1988-04-08 2003-01-08 Stryker Corporation Osteogenic devices
US5258494A (en) 1988-04-08 1993-11-02 Stryker Corporation Osteogenic proteins
US5011691A (en) * 1988-08-15 1991-04-30 Stryker Corporation Osteogenic devices
US5670336A (en) * 1988-04-08 1997-09-23 Stryker Corporation Method for recombinant production of osteogenic protein
US5354557A (en) * 1988-04-08 1994-10-11 Stryker Corporation Osteogenic devices
US6586388B2 (en) 1988-04-08 2003-07-01 Stryker Corporation Method of using recombinant osteogenic protein to repair bone or cartilage defects
US5250302A (en) * 1988-04-08 1993-10-05 Stryker Corporation Osteogenic devices
US5108753A (en) * 1988-04-08 1992-04-28 Creative Biomolecules Osteogenic devices
US5266683A (en) * 1988-04-08 1993-11-30 Stryker Corporation Osteogenic proteins
US5284756A (en) * 1988-10-11 1994-02-08 Lynn Grinna Heterodimeric osteogenic factor
EP0429570B1 (en) * 1989-03-28 1998-01-14 Genetics Institute, Inc. Osteoinductive compositions
CA2020729A1 (en) * 1989-07-19 1991-01-20 Michael C. Kiefer Bone morphogenetic protein
DK0448704T3 (da) * 1989-10-17 1999-04-06 Stryker Corp Osteogene anordninger
EP0506785B1 (en) * 1989-12-20 2000-03-15 Autoimmune, Inc. Improved treatment of autoimmune diseases by aerosol administration of auto antigens
US5071655A (en) * 1990-01-12 1991-12-10 Baylink David J Pharmaceutical combination for treatment of bone-wasting diseases
ATE209251T1 (de) * 1990-05-16 2001-12-15 Genetics Inst Knochen- und knorpel-bildung hervorrufende proteine
US5364839A (en) * 1990-06-18 1994-11-15 Genetics Institute, Inc. Osteoinductive pharmaceutical formulations
EP0550625B1 (en) * 1990-09-26 2003-11-05 Genetics Institute, LLC Bmp-5 derivatives
CA2363965C (en) 1991-03-11 2010-05-18 Curis, Inc. Protein-induced morphogenesis
US5674844A (en) * 1991-03-11 1997-10-07 Creative Biomolecules, Inc. Treatment to prevent loss of and/or increase bone mass in metabolic bone diseases
US6395883B1 (en) 1991-03-11 2002-05-28 Curis, Inc. Soluble morphogenic protein complex compositions of matter
US5652337A (en) * 1991-03-11 1997-07-29 Creative Biomolecules, Inc. OP-3-induced morphogenesis
US6090776A (en) * 1991-03-11 2000-07-18 Creative Bio Molecules, Inc. Morphogen treatment of organ implants
US5656593A (en) * 1991-03-11 1997-08-12 Creative Biomolecules, Inc. Morphogen induced periodontal tissue regeneration
US5972884A (en) * 1991-03-11 1999-10-26 Creative Biomolecules, Inc. Morphogen treatment of gastrointestinal ulcers
US5849686A (en) * 1991-03-11 1998-12-15 Creative Biomolecules, Inc. Morphogen-induced liver regeneration
US6077823A (en) * 1991-03-11 2000-06-20 Creative Biomolecules, Inc. Method for reducing tissue damage associated with ischemia-reperfusion or hypoxia injury
US5652118A (en) * 1991-03-11 1997-07-29 Creative Biomolecules, Inc. Nucleic acid encoding a novel morphogenic protein, OP-3
US6800603B2 (en) 1991-03-11 2004-10-05 Curis, Inc. Morphogen-induced neural cell adhesion
US6495513B1 (en) 1991-03-11 2002-12-17 Curis, Inc. Morphogen-enhanced survival and repair of neural cells
US6399569B1 (en) 1991-03-11 2002-06-04 Curis, Inc. Morphogen treatments for limiting proliferation of epithelial cells
US7056882B2 (en) 1991-03-11 2006-06-06 Curis, Inc. Treatment to prevent loss of and/or increase bone mass in metabolic bone diseases
ZA923086B (en) * 1991-04-29 1993-10-28 South African Medical Research A delivery system for biologicaly active growth or morphogenetic factors and a method for preparing such delivery system
CA2111199C (en) * 1991-06-21 2008-08-05 Eyal Ron Pharmaceutical formulations of osteogenic proteins
US6022853A (en) * 1991-08-30 2000-02-08 Creative Biomolecules, Inc. Morphogen-enriched dietary composition
CA2116559C (en) * 1991-08-30 2005-05-10 Thangavel Kuberasampath Treatment to prevent loss of and/or increase bone mass in metabolic bone diseases
EP0612348B1 (en) * 1991-11-04 2003-04-23 Genetics Institute, LLC Recombinant bone morphogenetic protein heterodimers, compositions and methods of use
AU682154B2 (en) * 1992-09-15 1997-09-25 Creative Biomolecules, Inc. Morphogen treatment of gastrointestinal ulcers
ATE162078T1 (de) 1992-09-16 1998-01-15 Creative Biomolecules Inc Morphogeninduzierte regenerierung der leber
US6352972B1 (en) * 1995-06-06 2002-03-05 Marcel E. Nimni Bone morphogenetic proteins and their use in bone growth
TW200526779A (en) 2001-02-08 2005-08-16 Wyeth Corp Modified and stabilized GDF propeptides and uses thereof
US20110002897A1 (en) 2009-06-11 2011-01-06 Burnham Institute For Medical Research Directed differentiation of stem cells

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1988000205A1 (en) * 1986-07-01 1988-01-14 Genetics Institute, Inc. Novel osteoinductive compositions
WO1989009787A2 (en) * 1988-04-08 1989-10-19 Creative Biomolecules, Inc. Osteogenic devices

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4619989A (en) * 1981-05-05 1986-10-28 The Regents Of The University Of Cal. Bone morphogenetic protein composition
US4789732A (en) * 1980-08-04 1988-12-06 Regents Of The University Of California Bone morphogenetic protein composition
US4394370A (en) * 1981-09-21 1983-07-19 Jefferies Steven R Bone graft material for osseous defects and method of making same
US4795804A (en) * 1983-08-16 1989-01-03 The Regents Of The University Of California Bone morphogenetic agents
WO1986000525A1 (en) * 1984-07-13 1986-01-30 Economix Közgazdász Egyetemi Kisszövetkezet Process for the preparation of a pharmaceutical composition influencing the tissue metabolism and having a regenerating action
US4563350A (en) * 1984-10-24 1986-01-07 Collagen Corporation Inductive collagen based bone repair preparations

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1988000205A1 (en) * 1986-07-01 1988-01-14 Genetics Institute, Inc. Novel osteoinductive compositions
WO1989009787A2 (en) * 1988-04-08 1989-10-19 Creative Biomolecules, Inc. Osteogenic devices

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
SCIENCE, vol. 242, 16th December 1988, pages 1528-1534, Lancaster, PA, US; J.M. WOZNEY et al.: "Novel regulators of bone formation: Molecular clones and activities" *
See also references of WO8910409A1 *

Also Published As

Publication number Publication date
JPH03503649A (ja) 1991-08-15
KR900700617A (ko) 1990-08-16
AU645244B2 (en) 1994-01-13
EP0408649A1 (en) 1991-01-23
AU3448789A (en) 1989-11-24
WO1989010409A1 (en) 1989-11-02

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Legal Events

Date Code Title Description
PUAI Public reference made under article 153(3) epc to a published international application that has entered the european phase

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17P Request for examination filed

Effective date: 19901005

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