JP2011507903A5 - - Google Patents

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Publication number
JP2011507903A5
JP2011507903A5 JP2010539882A JP2010539882A JP2011507903A5 JP 2011507903 A5 JP2011507903 A5 JP 2011507903A5 JP 2010539882 A JP2010539882 A JP 2010539882A JP 2010539882 A JP2010539882 A JP 2010539882A JP 2011507903 A5 JP2011507903 A5 JP 2011507903A5
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JP
Japan
Prior art keywords
bmp
protein
amino acid
modified
wild
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP2010539882A
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English (en)
Japanese (ja)
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JP5529754B2 (ja
JP2011507903A (ja
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Application filed filed Critical
Priority claimed from PCT/US2008/087720 external-priority patent/WO2009086131A1/en
Publication of JP2011507903A publication Critical patent/JP2011507903A/ja
Publication of JP2011507903A5 publication Critical patent/JP2011507903A5/ja
Application granted granted Critical
Publication of JP5529754B2 publication Critical patent/JP5529754B2/ja
Expired - Fee Related legal-status Critical Current
Anticipated expiration legal-status Critical

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JP2010539882A 2007-12-21 2008-12-19 Ｎｏｇｇｉｎに対する感受性が低下したＢＭＰ変異体 Expired - Fee Related JP5529754B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US875407P 2007-12-21 2007-12-21
US61/008,754 2007-12-21
PCT/US2008/087720 WO2009086131A1 (en) 2007-12-21 2008-12-19 Bmp mutants with decreased susceptibility to noggin

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2014056688A Division JP2014121334A (ja) 2007-12-21 2014-03-19 Ｎｏｇｇｉｎに対する感受性が低下したＢＭＰ変異体

Publications (3)

Publication Number Publication Date
JP2011507903A JP2011507903A (ja) 2011-03-10
JP2011507903A5 true JP2011507903A5 (enExample) 2013-01-17
JP5529754B2 JP5529754B2 (ja) 2014-06-25

Family

ID=40424155

Family Applications (2)

Application Number Title Priority Date Filing Date
JP2010539882A Expired - Fee Related JP5529754B2 (ja) 2007-12-21 2008-12-19 Ｎｏｇｇｉｎに対する感受性が低下したＢＭＰ変異体
JP2014056688A Pending JP2014121334A (ja) 2007-12-21 2014-03-19 Ｎｏｇｇｉｎに対する感受性が低下したＢＭＰ変異体

Family Applications After (1)

Application Number Title Priority Date Filing Date
JP2014056688A Pending JP2014121334A (ja) 2007-12-21 2014-03-19 Ｎｏｇｇｉｎに対する感受性が低下したＢＭＰ変異体

Country Status (6)

Country Link
US (2) US20110039773A1 (enExample)
EP (1) EP2222696A1 (enExample)
JP (2) JP5529754B2 (enExample)
AU (1) AU2008345689B2 (enExample)
CA (1) CA2708549C (enExample)
WO (1) WO2009086131A1 (enExample)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1698691A1 (en) * 2005-03-04 2006-09-06 Biopharm Gesellschaft zur biotechnologischen Entwicklung von Pharmaka mbH Growth factor mutants with improved biological activity
JP5529754B2 (ja) * 2007-12-21 2014-06-25 ストライカー コーポレイション Ｎｏｇｇｉｎに対する感受性が低下したＢＭＰ変異体
AU2010223268B2 (en) * 2009-03-12 2015-04-23 Haase Investments Gmbh Bone morphogenetic protein 2 (BMP2 ) variants with reduced BMP antagonist sensitivity
CA2785038A1 (en) * 2009-12-22 2011-07-21 Stryker Corporation Bmp-7 variants with reduced immunogenicity
AU2015202418B2 (en) * 2010-08-20 2017-02-02 Wyeth Llc Designer osteogenic proteins
US9856305B2 (en) 2010-08-20 2018-01-02 Wyeth Llc Designer osteogenic proteins
WO2012023113A2 (en) * 2010-08-20 2012-02-23 Wyeth Llc Designer osteogenic proteins
US9688735B2 (en) 2010-08-20 2017-06-27 Wyeth Llc Designer osteogenic proteins
US9051389B2 (en) 2013-01-25 2015-06-09 Warsaw Orthopedic, Inc. Expression conditions and methods of human recombinant growth and differentiation factor-5 (rhGDF-5)
US9169308B2 (en) 2013-01-25 2015-10-27 Warsaw Orthopedic, Inc. Methods and compositions of human recombinant growth and differentiation factor-5 (rhGDF-5) isolated from inclusion bodies
US9359417B2 (en) 2013-01-25 2016-06-07 Warsaw Orthopedic, Inc. Cell cultures and methods of human recombinant growth and differentiaton factor-5 (rhGDF-5)
US8945872B2 (en) 2013-01-25 2015-02-03 Warsaw Orthopedic, Inc. Methods of purifying human recombinant growth and differentiation factor-5 (rhGDF-5) protein
US8956829B2 (en) 2013-01-25 2015-02-17 Warsaw Orthopedic, Inc. Human recombinant growth and differentiaton factor-5 (rhGDF-5)
EP2784083A1 (en) * 2013-03-28 2014-10-01 Charité - Universitätsmedizin Berlin Bone Morphogenetic Protein (BMP) variants with highly reduced antagonist sensitivity and enhanced specific biological activity
EP3171886A4 (en) * 2014-07-21 2018-01-24 The Arizona Board of Regents On Behalf of the University of Arizona Ang-(1-7) derviative oligopeptides and methods for using and producing the same
US10183055B2 (en) 2014-07-21 2019-01-22 Arizona Board Of Regents On Behalf Of The University Of Arizona Ang-(1-7) derivative oligopeptides for the treatment of pain and other indications
WO2016131052A1 (en) 2015-02-13 2016-08-18 Factor Bioscience Inc. Nucleic acid products and methods of administration thereof
CN107708416B (zh) * 2015-05-01 2021-06-29 Onl医疗股份有限公司 肽组合物和使用方法
IL308824A (en) 2016-08-17 2024-01-01 Factor Bioscience Inc Nucleic acid products and methods of administration thereof
PE20200385A1 (es) 2017-04-27 2020-02-24 Lilly Co Eli Variantes de proteina morfogenica osea humana 7 (bmp7)

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE10026713A1 (de) * 2000-05-30 2001-12-06 Walter Sebald Mutein einer Kette eines Proteins aus der Superfamilie des Wachstumsfaktors TGF-beta
WO2005097825A2 (en) * 2004-03-31 2005-10-20 Xencor, Inc. Bmp-7 variants with improved properties
JP2008509087A (ja) * 2004-05-27 2008-03-27 アクセルロン ファーマ インコーポレーテッド Ｔｇｆ抑制解除因子およびそれに関連する使用方法
WO2008051526A2 (en) * 2006-10-23 2008-05-02 Stryker Corporation Bone morphogenetic proteins
JP5529754B2 (ja) * 2007-12-21 2014-06-25 ストライカー コーポレイション Ｎｏｇｇｉｎに対する感受性が低下したＢＭＰ変異体

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