JP2011507903A5 - - Google Patents
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- Publication number
- JP2011507903A5 JP2011507903A5 JP2010539882A JP2010539882A JP2011507903A5 JP 2011507903 A5 JP2011507903 A5 JP 2011507903A5 JP 2010539882 A JP2010539882 A JP 2010539882A JP 2010539882 A JP2010539882 A JP 2010539882A JP 2011507903 A5 JP2011507903 A5 JP 2011507903A5
- Authority
- JP
- Japan
- Prior art keywords
- bmp
- protein
- amino acid
- modified
- wild
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 125000003275 alpha amino acid group Chemical group 0.000 claims 41
- 238000006467 substitution reaction Methods 0.000 claims 41
- 108010049870 Bone Morphogenetic Protein 7 Proteins 0.000 claims 38
- 102100022544 Bone morphogenetic protein 7 Human genes 0.000 claims 38
- 235000001014 amino acid Nutrition 0.000 claims 34
- 235000018102 proteins Nutrition 0.000 claims 26
- 102000004169 proteins and genes Human genes 0.000 claims 26
- 108090000623 proteins and genes Proteins 0.000 claims 26
- 210000004899 c-terminal region Anatomy 0.000 claims 14
- 235000018417 cysteine Nutrition 0.000 claims 14
- XUJNEKJLAYXESH-UHFFFAOYSA-N cysteine Natural products SCC(N)C(O)=O XUJNEKJLAYXESH-UHFFFAOYSA-N 0.000 claims 14
- 102220034160 rs113842820 Human genes 0.000 claims 12
- 102200160798 rs5122 Human genes 0.000 claims 11
- 102220344807 c.193T>A Human genes 0.000 claims 10
- 102000007350 Bone Morphogenetic Proteins Human genes 0.000 claims 9
- 108010007726 Bone Morphogenetic Proteins Proteins 0.000 claims 9
- 102220504701 Galanin receptor type 1_S77A_mutation Human genes 0.000 claims 9
- 229940112869 bone morphogenetic protein Drugs 0.000 claims 9
- 102200124656 rs6267 Human genes 0.000 claims 9
- 102220144494 rs200079698 Human genes 0.000 claims 7
- 108010049931 Bone Morphogenetic Protein 2 Proteins 0.000 claims 6
- 102100024506 Bone morphogenetic protein 2 Human genes 0.000 claims 6
- 150000001413 amino acids Chemical class 0.000 claims 6
- 102220055260 rs140446520 Human genes 0.000 claims 6
- 108010090254 Growth Differentiation Factor 5 Proteins 0.000 claims 4
- 108010090250 Growth Differentiation Factor 6 Proteins 0.000 claims 4
- 102100035379 Growth/differentiation factor 5 Human genes 0.000 claims 4
- 102100035368 Growth/differentiation factor 6 Human genes 0.000 claims 4
- 102100035363 Growth/differentiation factor 7 Human genes 0.000 claims 4
- 101710204283 Growth/differentiation factor 7 Proteins 0.000 claims 4
- 230000005764 inhibitory process Effects 0.000 claims 4
- 102000045246 noggin Human genes 0.000 claims 4
- 108700007229 noggin Proteins 0.000 claims 4
- 239000008194 pharmaceutical composition Substances 0.000 claims 4
- 108010049955 Bone Morphogenetic Protein 4 Proteins 0.000 claims 3
- 108010049976 Bone Morphogenetic Protein 5 Proteins 0.000 claims 3
- 102100024505 Bone morphogenetic protein 4 Human genes 0.000 claims 3
- 102100022526 Bone morphogenetic protein 5 Human genes 0.000 claims 3
- 101000899390 Homo sapiens Bone morphogenetic protein 6 Proteins 0.000 claims 3
- 102000046095 human BMP6 Human genes 0.000 claims 3
- 102220520196 Barrier-to-autointegration factor_L50K_mutation Human genes 0.000 claims 2
- 102220515504 Interferon gamma_K29Q_mutation Human genes 0.000 claims 2
- 102220509305 Small integral membrane protein 10_D34Q_mutation Human genes 0.000 claims 2
- 239000003937 drug carrier Substances 0.000 claims 2
- 102000039446 nucleic acids Human genes 0.000 claims 2
- 108020004707 nucleic acids Proteins 0.000 claims 2
- 150000007523 nucleic acids Chemical class 0.000 claims 2
- 102220310822 rs1186663823 Human genes 0.000 claims 2
- 102220238245 rs1555952639 Human genes 0.000 claims 2
- 102220005146 rs35262412 Human genes 0.000 claims 2
- 102220064893 rs35669569 Human genes 0.000 claims 2
- 102200097281 rs35807406 Human genes 0.000 claims 2
- 102200105532 rs397509387 Human genes 0.000 claims 2
- 102220001969 rs696217 Human genes 0.000 claims 2
- 102220478560 Apoptosis regulator Bcl-2_D36S_mutation Human genes 0.000 claims 1
- 102220478542 Apoptosis regulator Bcl-2_E53A_mutation Human genes 0.000 claims 1
- 102220520197 Barrier-to-autointegration factor_V51E_mutation Human genes 0.000 claims 1
- 102220530630 Beta-galactosidase_L57M_mutation Human genes 0.000 claims 1
- 108010049974 Bone Morphogenetic Protein 6 Proteins 0.000 claims 1
- 102000008154 Bone Morphogenetic Protein 6 Human genes 0.000 claims 1
- 102220485589 CHRNA7-FAM7A fusion protein_Q41A_mutation Human genes 0.000 claims 1
- 102220546737 Coiled-coil domain-containing protein 24_D55E_mutation Human genes 0.000 claims 1
- 102220550869 Fumarate hydratase, mitochondrial_N29Q_mutation Human genes 0.000 claims 1
- 102220504907 Galanin receptor type 1_S67A_mutation Human genes 0.000 claims 1
- 102220504814 Galanin receptor type 1_V35I_mutation Human genes 0.000 claims 1
- 102220580969 Induced myeloid leukemia cell differentiation protein Mcl-1_Y46Y_mutation Human genes 0.000 claims 1
- 102220466759 Olfactory receptor 13C5_L69M_mutation Human genes 0.000 claims 1
- 102220642088 Prolactin-inducible protein_V26L_mutation Human genes 0.000 claims 1
- 102220495230 Sodium channel subunit beta-2_K38Q_mutation Human genes 0.000 claims 1
- 102220493338 Sodium/calcium exchanger 3_H39A_mutation Human genes 0.000 claims 1
- 230000004071 biological effect Effects 0.000 claims 1
- 210000000988 bone and bone Anatomy 0.000 claims 1
- 102220426871 c.117G>C Human genes 0.000 claims 1
- 102220345409 c.147A>C Human genes 0.000 claims 1
- 210000000845 cartilage Anatomy 0.000 claims 1
- 230000000694 effects Effects 0.000 claims 1
- 102000035118 modified proteins Human genes 0.000 claims 1
- 108091005573 modified proteins Proteins 0.000 claims 1
- 102200009943 rs116840808 Human genes 0.000 claims 1
- 102200068503 rs121964997 Human genes 0.000 claims 1
- 102220318682 rs1399431033 Human genes 0.000 claims 1
- 102200079013 rs1554763777 Human genes 0.000 claims 1
- 102200097256 rs199473492 Human genes 0.000 claims 1
- 102220142876 rs200087565 Human genes 0.000 claims 1
- 102220112531 rs2240308 Human genes 0.000 claims 1
- 102200118306 rs33919924 Human genes 0.000 claims 1
- 102220005517 rs33931984 Human genes 0.000 claims 1
- 102200005620 rs34282046 Human genes 0.000 claims 1
- 102220273513 rs373435521 Human genes 0.000 claims 1
- 102220010866 rs397514631 Human genes 0.000 claims 1
- 102220044659 rs587781460 Human genes 0.000 claims 1
- 102220203572 rs6926224 Human genes 0.000 claims 1
- 102220289725 rs778831047 Human genes 0.000 claims 1
- 102200089536 rs854560 Human genes 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US875407P | 2007-12-21 | 2007-12-21 | |
| US61/008,754 | 2007-12-21 | ||
| PCT/US2008/087720 WO2009086131A1 (en) | 2007-12-21 | 2008-12-19 | Bmp mutants with decreased susceptibility to noggin |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014056688A Division JP2014121334A (ja) | 2007-12-21 | 2014-03-19 | Ｎｏｇｇｉｎに対する感受性が低下したＢＭＰ変異体 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2011507903A JP2011507903A (ja) | 2011-03-10 |
| JP2011507903A5 true JP2011507903A5 (enExample) | 2013-01-17 |
| JP5529754B2 JP5529754B2 (ja) | 2014-06-25 |
Family
ID=40424155
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010539882A Expired - Fee Related JP5529754B2 (ja) | 2007-12-21 | 2008-12-19 | Ｎｏｇｇｉｎに対する感受性が低下したＢＭＰ変異体 |
| JP2014056688A Pending JP2014121334A (ja) | 2007-12-21 | 2014-03-19 | Ｎｏｇｇｉｎに対する感受性が低下したＢＭＰ変異体 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014056688A Pending JP2014121334A (ja) | 2007-12-21 | 2014-03-19 | Ｎｏｇｇｉｎに対する感受性が低下したＢＭＰ変異体 |
Country Status (6)
| Country | Link |
|---|---|
| US (2) | US20110039773A1 (enExample) |
| EP (1) | EP2222696A1 (enExample) |
| JP (2) | JP5529754B2 (enExample) |
| AU (1) | AU2008345689B2 (enExample) |
| CA (1) | CA2708549C (enExample) |
| WO (1) | WO2009086131A1 (enExample) |
Families Citing this family (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1698691A1 (en) * | 2005-03-04 | 2006-09-06 | Biopharm Gesellschaft zur biotechnologischen Entwicklung von Pharmaka mbH | Growth factor mutants with improved biological activity |
| EP2222696A1 (en) * | 2007-12-21 | 2010-09-01 | Stryker Corporation | Bmp mutants with decreased susceptibility to noggin |
| JP5749659B2 (ja) * | 2009-03-12 | 2015-07-15 | ハーゼ インベストメンツ ウーゲー | Ｂｍｐアンタゴニスト感受性が低下した骨形成タンパク質２（ｂｍｐ２）変異体 |
| EP2516456A1 (en) * | 2009-12-22 | 2012-10-31 | Stryker Corporation | Bmp-7 variants with reduced immunogenicity |
| AU2015202418B2 (en) * | 2010-08-20 | 2017-02-02 | Wyeth Llc | Designer osteogenic proteins |
| CA2807343C (en) | 2010-08-20 | 2018-05-22 | Wyeth Llc | Designer osteogenic proteins |
| US9856305B2 (en) | 2010-08-20 | 2018-01-02 | Wyeth Llc | Designer osteogenic proteins |
| US9688735B2 (en) * | 2010-08-20 | 2017-06-27 | Wyeth Llc | Designer osteogenic proteins |
| US9051389B2 (en) | 2013-01-25 | 2015-06-09 | Warsaw Orthopedic, Inc. | Expression conditions and methods of human recombinant growth and differentiation factor-5 (rhGDF-5) |
| US9359417B2 (en) | 2013-01-25 | 2016-06-07 | Warsaw Orthopedic, Inc. | Cell cultures and methods of human recombinant growth and differentiaton factor-5 (rhGDF-5) |
| US8945872B2 (en) | 2013-01-25 | 2015-02-03 | Warsaw Orthopedic, Inc. | Methods of purifying human recombinant growth and differentiation factor-5 (rhGDF-5) protein |
| US8956829B2 (en) | 2013-01-25 | 2015-02-17 | Warsaw Orthopedic, Inc. | Human recombinant growth and differentiaton factor-5 (rhGDF-5) |
| US9169308B2 (en) | 2013-01-25 | 2015-10-27 | Warsaw Orthopedic, Inc. | Methods and compositions of human recombinant growth and differentiation factor-5 (rhGDF-5) isolated from inclusion bodies |
| EP2784083A1 (en) * | 2013-03-28 | 2014-10-01 | Charité - Universitätsmedizin Berlin | Bone Morphogenetic Protein (BMP) variants with highly reduced antagonist sensitivity and enhanced specific biological activity |
| US10183055B2 (en) | 2014-07-21 | 2019-01-22 | Arizona Board Of Regents On Behalf Of The University Of Arizona | Ang-(1-7) derivative oligopeptides for the treatment of pain and other indications |
| EP3171886A4 (en) * | 2014-07-21 | 2018-01-24 | The Arizona Board of Regents On Behalf of the University of Arizona | Ang-(1-7) derviative oligopeptides and methods for using and producing the same |
| CA2976376A1 (en) | 2015-02-13 | 2016-08-18 | Factor Bioscience Inc. | Nucleic acid products and methods of administration thereof |
| PL3288379T3 (pl) | 2015-05-01 | 2022-03-07 | Onl Therapeutics, Inc. | Kompozycje peptydowe i sposoby stosowania |
| US10576167B2 (en) | 2016-08-17 | 2020-03-03 | Factor Bioscience Inc. | Nucleic acid products and methods of administration thereof |
| MX2019012871A (es) | 2017-04-27 | 2021-01-08 | Lilly Co Eli | Variantes de proteina morfogenica osea humana 7 (bmp7). |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE10026713A1 (de) * | 2000-05-30 | 2001-12-06 | Walter Sebald | Mutein einer Kette eines Proteins aus der Superfamilie des Wachstumsfaktors TGF-beta |
| JP2008500816A (ja) * | 2004-03-31 | 2008-01-17 | ゼンコー・インコーポレイテッド | 改善された性質を有するｂｍｐ−７変異体 |
| CA2567805A1 (en) * | 2004-05-27 | 2005-12-15 | Acceleron Pharma Inc. | Tgf derepressors and uses related thereto |
| WO2008051526A2 (en) * | 2006-10-23 | 2008-05-02 | Stryker Corporation | Bone morphogenetic proteins |
| EP2222696A1 (en) * | 2007-12-21 | 2010-09-01 | Stryker Corporation | Bmp mutants with decreased susceptibility to noggin |
-
2008
- 2008-12-19 EP EP08867546A patent/EP2222696A1/en not_active Withdrawn
- 2008-12-19 WO PCT/US2008/087720 patent/WO2009086131A1/en not_active Ceased
- 2008-12-19 AU AU2008345689A patent/AU2008345689B2/en not_active Ceased
- 2008-12-19 US US12/746,821 patent/US20110039773A1/en not_active Abandoned
- 2008-12-19 CA CA2708549A patent/CA2708549C/en not_active Expired - Fee Related
- 2008-12-19 JP JP2010539882A patent/JP5529754B2/ja not_active Expired - Fee Related
-
2012
- 2012-11-30 US US13/690,211 patent/US20130184208A1/en not_active Abandoned
-
2014
- 2014-03-19 JP JP2014056688A patent/JP2014121334A/ja active Pending
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