JP2014520120A5 - - Google Patents

Download PDF

Info

Publication number
JP2014520120A5
JP2014520120A5 JP2014516044A JP2014516044A JP2014520120A5 JP 2014520120 A5 JP2014520120 A5 JP 2014520120A5 JP 2014516044 A JP2014516044 A JP 2014516044A JP 2014516044 A JP2014516044 A JP 2014516044A JP 2014520120 A5 JP2014520120 A5 JP 2014520120A5
Authority
JP
Japan
Prior art keywords
amino acid
amino acids
substituted
polypeptide
independently
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2014516044A
Other languages
English (en)
Japanese (ja)
Other versions
JP2014520120A (ja
Filing date
Publication date
Application filed filed Critical
Priority claimed from PCT/US2012/042719 external-priority patent/WO2012174409A1/en
Publication of JP2014520120A publication Critical patent/JP2014520120A/ja
Publication of JP2014520120A5 publication Critical patent/JP2014520120A5/ja
Pending legal-status Critical Current

Links

JP2014516044A 2011-06-17 2012-06-15 安定化した変異型mamlペプチドおよびその使用 Pending JP2014520120A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201161498477P 2011-06-17 2011-06-17
US61/498,477 2011-06-17
PCT/US2012/042719 WO2012174409A1 (en) 2011-06-17 2012-06-15 Stabilized variant maml peptides and uses thereof

Publications (2)

Publication Number Publication Date
JP2014520120A JP2014520120A (ja) 2014-08-21
JP2014520120A5 true JP2014520120A5 (enExample) 2015-07-30

Family

ID=47357495

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2014516044A Pending JP2014520120A (ja) 2011-06-17 2012-06-15 安定化した変異型mamlペプチドおよびその使用

Country Status (4)

Country Link
US (1) US20140256912A1 (enExample)
EP (1) EP2721061A4 (enExample)
JP (1) JP2014520120A (enExample)
WO (1) WO2012174409A1 (enExample)

Families Citing this family (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7192713B1 (en) 1999-05-18 2007-03-20 President And Fellows Of Harvard College Stabilized compounds having secondary structure motifs
WO2005044839A2 (en) 2003-11-05 2005-05-19 Dana-Farber Cancer Institute, Inc. Stabilized alpha helical peptides and uses thereof
JP5631201B2 (ja) 2007-03-28 2014-11-26 プレジデント アンド フェローズ オブ ハーバード カレッジ ステッチングされたポリペプチド
US20110144306A1 (en) 2008-07-23 2011-06-16 President And Fellows Of Harvard College Ligation of stapled polypeptides
AU2010204648B2 (en) 2009-01-14 2016-09-01 Aileron Therapeutics, Inc. Peptidomimetic macrocycles
BR112012000867A2 (pt) 2009-07-13 2019-09-24 Harvard College "polipeptídeos bifuncional costurado e uso do mesmo"
JP2013505300A (ja) 2009-09-22 2013-02-14 エルロン・セラピューティクス・インコーポレイテッド ペプチド模倣大環状分子
KR102104762B1 (ko) 2010-08-13 2020-04-24 에일러론 테라퓨틱스 인코포레이티드 펩티도미메틱 거대고리
WO2012174423A1 (en) 2011-06-17 2012-12-20 President And Fellows Of Harvard College Stabilized polypeptides as regulators of rab gtpase function
EP2768518A4 (en) 2011-10-18 2015-05-27 Aileron Therapeutics Inc PEPTIDOMIMETIC MACROCYCLES
RU2642299C2 (ru) 2012-02-15 2018-01-24 Эйлерон Терапьютикс, Инк. P53 пептидомиметические макроциклы
CA2864120A1 (en) 2012-02-15 2013-08-22 Aileron Therapeutics, Inc. Triazole-crosslinked and thioether-crosslinked peptidomimetic macrocycles
RS61957B1 (sr) 2012-09-26 2021-07-30 Harvard College Uvezani peptidi blokirani prolinom i njihove upotrebe
BR112015009470A2 (pt) 2012-11-01 2019-12-17 Aileron Therapeutics Inc aminoácidos dissubstituídos e seus métodos de preparação e uso
KR20150131244A (ko) 2013-03-13 2015-11-24 프레지던트 앤드 펠로우즈 오브 하바드 칼리지 스테이플드 및 스티치드 폴리펩티드 및 그의 용도
WO2014151369A2 (en) 2013-03-15 2014-09-25 Dana-Farber Cancer Institute, Inc. Stabilized ezh2 peptides
BR112015031277A2 (pt) 2013-06-14 2017-09-19 Harvard College Moduladores do receptor de insulina de polipeptídeos estabilizados, análogos de insulina, composições farmacêuticas compreendendo os referidos polipeptídeos e métodos de preparação e usos dos mesmos
EP3145523A4 (en) 2014-05-21 2018-02-21 President and Fellows of Harvard College Ras inhibitory peptides and uses thereof
EP3197478A4 (en) 2014-09-24 2018-05-30 Aileron Therapeutics, Inc. Peptidomimetic macrocycles and uses thereof
CN107106642B (zh) 2014-09-24 2021-02-26 艾瑞朗医疗公司 拟肽大环化合物及其制剂
JP2018516844A (ja) 2015-03-20 2018-06-28 エルロン・セラピューティクス・インコーポレイテッドAileron Therapeutics,Inc. ペプチド模倣大環状分子およびその使用
US10059741B2 (en) 2015-07-01 2018-08-28 Aileron Therapeutics, Inc. Peptidomimetic macrocycles
EP3347372A4 (en) 2015-09-10 2019-09-04 Aileron Therapeutics, Inc. PEPTIDOMIMETIC MACROCYCLES AS MODULATORS OF MCL-1
US20190135868A1 (en) * 2016-04-29 2019-05-09 The University Of Chicago Synthetic dna binding domain peptides and uses thereof
EA202090513A1 (ru) 2017-09-07 2020-08-24 Фог Фармасьютикалз, Инк. Агенты, модулирующие функции бета-катенина, и связанные способы
WO2019136209A1 (en) * 2018-01-05 2019-07-11 President And Fellows Of Harvard College Stabilized polypeptides and uses thereof
BR112021003113A2 (pt) 2018-08-20 2021-05-11 Fog Pharmaceuticals, Inc. coleções de peptídeos, agentes de peptídeos e métodos de uso dos mesmos
EP4600411A3 (en) 2019-04-09 2025-09-10 The University of Chicago Versatile peptide and protein macrocyclization and multimerization with diels-alder cycloadditions

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2010510236A (ja) * 2006-11-15 2010-04-02 ダナ−ファーバー キャンサー インスティテュート インク. 安定化させたmamlペプチドおよびその使用法
CN102482336B (zh) * 2008-09-22 2015-05-06 爱勒让治疗公司 拟肽大环化合物
WO2010034029A1 (en) * 2008-09-22 2010-03-25 Aileron Therapeutics, Inc. Peptidomimetic macrocycles

Similar Documents

Publication Publication Date Title
JP2010518017A5 (enExample)
JP2014224121A5 (enExample)
JP2019514426A5 (enExample)
ES2876939T3 (es) Péptidos penetradores de células que tienen un dominio hidrófobo central
CO2020001113A2 (es) Muteínas de interleucina 21 y métodos de tratamiento
JP2011502964A5 (enExample)
JP2010532168A5 (enExample)
JP2022518695A5 (enExample)
CA2862391C (en) Stabilized antiviral fusion helices
RU2016146198A (ru) Терапевтические dll4-связывающие белки
RU2017134456A (ru) Рекомбинантные связывающие белки и их применение
JP2014534220A5 (enExample)
JP2015522576A5 (enExample)
JP2007530441A5 (enExample)
JP7846169B2 (ja) 細胞透過性ペプチド
JP2022513223A5 (enExample)
JP2012505657A5 (enExample)
JP2013500990A5 (enExample)
JP2006506942A5 (enExample)
RU2016130448A (ru) Пептидные дендримеры, содержащие фибриноген-связывающие пептиды
JP2016535058A5 (enExample)
JP2014526881A5 (enExample)
JP2015522264A5 (enExample)
JP2023554379A5 (enExample)
JP2024509241A5 (enExample)