JP2014520120A5 - - Google Patents

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Publication number
JP2014520120A5
JP2014520120A5 JP2014516044A JP2014516044A JP2014520120A5 JP 2014520120 A5 JP2014520120 A5 JP 2014520120A5 JP 2014516044 A JP2014516044 A JP 2014516044A JP 2014516044 A JP2014516044 A JP 2014516044A JP 2014520120 A5 JP2014520120 A5 JP 2014520120A5
Authority
JP
Japan
Prior art keywords
amino acid
amino acids
substituted
polypeptide
independently
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2014516044A
Other languages
English (en)
Japanese (ja)
Other versions
JP2014520120A (ja
Filing date
Publication date
Application filed filed Critical
Priority claimed from PCT/US2012/042719 external-priority patent/WO2012174409A1/en
Publication of JP2014520120A publication Critical patent/JP2014520120A/ja
Publication of JP2014520120A5 publication Critical patent/JP2014520120A5/ja
Pending legal-status Critical Current

Links

JP2014516044A 2011-06-17 2012-06-15 安定化した変異型mamlペプチドおよびその使用 Pending JP2014520120A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201161498477P 2011-06-17 2011-06-17
US61/498,477 2011-06-17
PCT/US2012/042719 WO2012174409A1 (en) 2011-06-17 2012-06-15 Stabilized variant maml peptides and uses thereof

Publications (2)

Publication Number Publication Date
JP2014520120A JP2014520120A (ja) 2014-08-21
JP2014520120A5 true JP2014520120A5 (enExample) 2015-07-30

Family

ID=47357495

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2014516044A Pending JP2014520120A (ja) 2011-06-17 2012-06-15 安定化した変異型mamlペプチドおよびその使用

Country Status (4)

Country Link
US (1) US20140256912A1 (enExample)
EP (1) EP2721061A4 (enExample)
JP (1) JP2014520120A (enExample)
WO (1) WO2012174409A1 (enExample)

Families Citing this family (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7192713B1 (en) 1999-05-18 2007-03-20 President And Fellows Of Harvard College Stabilized compounds having secondary structure motifs
EP1680443B9 (en) 2003-11-05 2014-09-03 Dana-Farber Cancer Institute, Inc. Stabilized alpha helical peptides and uses thereof
EP2508531B1 (en) 2007-03-28 2016-10-19 President and Fellows of Harvard College Stitched polypeptides
EP2356139A4 (en) 2008-07-23 2013-01-09 Harvard College LIGURE COMBINED POLYPEPTIDES
EP2376100B1 (en) 2009-01-14 2017-10-25 Aileron Therapeutics, Inc. Peptidomimetic macrocycles
WO2011008260A2 (en) 2009-07-13 2011-01-20 President And Fellows Of Harvard College Bifunctional stapled polypeptides and uses thereof
CA2774973A1 (en) 2009-09-22 2011-03-31 Aileron Therapeutics, Inc. Peptidomimetic macrocycles
SI2603600T1 (sl) 2010-08-13 2019-04-30 Aileron Therapeutics, Inc. Peptidomimetični makrocikli
WO2012174423A1 (en) 2011-06-17 2012-12-20 President And Fellows Of Harvard College Stabilized polypeptides as regulators of rab gtpase function
TW201806968A (zh) 2011-10-18 2018-03-01 艾利倫治療公司 擬肽巨環化合物
KR102112373B1 (ko) 2012-02-15 2020-05-18 에일러론 테라퓨틱스 인코포레이티드 펩티드모방체 마크로사이클
HK1205454A1 (en) 2012-02-15 2015-12-18 Aileron Therapeutics, Inc. Triazole-crosslinked and thioether-crosslinked peptidomimetic macrocycles
CA3113959A1 (en) 2012-09-26 2014-04-03 President And Fellows Of Harvard College Proline-locked stapled peptides and uses thereof
WO2014071241A1 (en) 2012-11-01 2014-05-08 Aileron Therapeutics, Inc. Disubstituted amino acids and methods of preparation and use thereof
EP3782638A1 (en) 2013-03-13 2021-02-24 President and Fellows of Harvard College Stapled and stitched polypeptides and uses thereof
WO2014151369A2 (en) 2013-03-15 2014-09-25 Dana-Farber Cancer Institute, Inc. Stabilized ezh2 peptides
WO2014201370A1 (en) 2013-06-14 2014-12-18 President And Fellows Of Harvard College Stabilized polypeptide insulin receptor modulators
CN114805527A (zh) 2014-05-21 2022-07-29 哈佛大学的校长及成员们 Ras抑制肽和其用途
JP2018503595A (ja) 2014-09-24 2018-02-08 エルロン・セラピューティクス・インコーポレイテッドAileron Therapeutics,Inc. ペプチド模倣大環状分子およびその製剤
BR112017005598A2 (pt) 2014-09-24 2017-12-12 Aileron Therapeutics Inc macrociclos peptidomiméticos e usos dos mesmos
WO2016154058A1 (en) 2015-03-20 2016-09-29 Aileron Therapeutics, Inc. Peptidomimetic macrocycles and uses thereof
US10059741B2 (en) 2015-07-01 2018-08-28 Aileron Therapeutics, Inc. Peptidomimetic macrocycles
US10023613B2 (en) 2015-09-10 2018-07-17 Aileron Therapeutics, Inc. Peptidomimetic macrocycles as modulators of MCL-1
WO2017190061A1 (en) * 2016-04-29 2017-11-02 The University Of Chicago Synthetic dna binding domain peptides and uses thereof
BR112020004555A2 (pt) 2017-09-07 2020-09-24 Fog Pharmaceuticals, Inc. agentes que modulam funções de beta-catenina e métodos dos mesmos
US11434263B2 (en) 2018-01-05 2022-09-06 President And Fellows Of Harvard College Stabilized polypeptides and uses thereof
AU2019326423A1 (en) 2018-08-20 2021-04-08 Fog Pharmaceuticals, Inc. Collections of peptides, peptide agents, and methods of use thereof
EP3953367B1 (en) 2019-04-09 2026-02-11 The University of Chicago Versatile peptide and protein macrocyclization and multimerization with diels-alder cycloadditions

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2010510236A (ja) * 2006-11-15 2010-04-02 ダナ−ファーバー キャンサー インスティテュート インク. 安定化させたmamlペプチドおよびその使用法
US8524653B2 (en) * 2008-09-22 2013-09-03 Aileron Therapeutics, Inc. Peptidomimetic macrocycles
CA2737918A1 (en) * 2008-09-22 2010-03-25 Aileron Therapeutics, Inc. Peptidomimetic macrocycles

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