|
AU2003225410A1
(en)
*
|
2003-03-21 |
2004-10-11 |
Academisch Ziekenhuis Leiden |
Modulation of exon recognition in pre-mrna by interfering with the secondary rna structure
|
|
EP2351844B1
(en)
|
2003-04-29 |
2014-06-11 |
Sarepta Therapeutics, Inc. |
Compositions for enhancing transport and antisense efficacy of nucleic acid analog into cells
|
|
US20050222068A1
(en)
*
|
2003-10-23 |
2005-10-06 |
Mourich Dan V |
Method and antisense composition for selective inhibition of HIV infection in hematopoietic cells
|
|
WO2005072527A2
(en)
*
|
2004-01-23 |
2005-08-11 |
Avi Biopharma, Inc. |
Antisense oligomers and methods for inducing immune tolerance and immunosuppression
|
|
US20050288246A1
(en)
|
2004-05-24 |
2005-12-29 |
Iversen Patrick L |
Peptide conjugated, inosine-substituted antisense oligomer compound and method
|
|
HRP20110352T1
(hr)
|
2004-06-28 |
2011-06-30 |
The University Of Western Australia |
Antisens olinukleotidi za induciranje zaobilaženja egzona i postupci njihove upotrebe
|
|
US8129352B2
(en)
*
|
2004-09-16 |
2012-03-06 |
Avi Biopharma, Inc. |
Antisense antiviral compound and method for treating ssRNA viral infection
|
|
CA2596506C
(en)
*
|
2005-02-09 |
2021-04-06 |
Avi Biopharma, Inc. |
Antisense composition and method for treating muscle atrophy
|
|
US8067571B2
(en)
|
2005-07-13 |
2011-11-29 |
Avi Biopharma, Inc. |
Antibacterial antisense oligonucleotide and method
|
|
WO2007030691A2
(en)
*
|
2005-09-08 |
2007-03-15 |
Avi Biopharma, Inc. |
Antisense antiviral compound and method for treating picornavirus infection
|
|
US8168181B2
(en)
|
2006-02-13 |
2012-05-01 |
Alethia Biotherapeutics, Inc. |
Methods of impairing osteoclast differentiation using antibodies that bind siglec-15
|
|
EP2438962A3
(en)
|
2006-02-13 |
2012-07-18 |
Alethia Biotherapeutics Inc. |
Polynucleotides and polypeptide sequences involved in the process of bone remodeling
|
|
US8785407B2
(en)
*
|
2006-05-10 |
2014-07-22 |
Sarepta Therapeutics, Inc. |
Antisense antiviral agent and method for treating ssRNA viral infection
|
|
US20100016215A1
(en)
|
2007-06-29 |
2010-01-21 |
Avi Biopharma, Inc. |
Compound and method for treating myotonic dystrophy
|
|
CA2704049A1
(en)
|
2007-10-26 |
2009-04-30 |
Academisch Ziekenhuis Leiden |
Means and methods for counteracting muscle disorders
|
|
US7989608B2
(en)
*
|
2007-12-28 |
2011-08-02 |
Avi Biopharma Inc. |
Immunomodulatory agents and methods of use
|
|
EP2119783A1
(en)
*
|
2008-05-14 |
2009-11-18 |
Prosensa Technologies B.V. |
Method for efficient exon (44) skipping in Duchenne Muscular Dystrophy and associated means
|
|
US8231895B2
(en)
|
2008-05-22 |
2012-07-31 |
Universidade De Coimbra |
Targeted delivery to human diseases and disorders
|
|
WO2009144481A2
(en)
*
|
2008-05-30 |
2009-12-03 |
Isis Innovation Limited |
Conjugates for delivery of biologically active compounds
|
|
JP2011523557A
(ja)
*
|
2008-06-04 |
2011-08-18 |
メディカル リサーチ カウンシル |
ペプチド
|
|
US8084601B2
(en)
|
2008-09-11 |
2011-12-27 |
Royal Holloway And Bedford New College Royal Holloway, University Of London |
Oligomers
|
|
WO2010048586A1
(en)
|
2008-10-24 |
2010-04-29 |
Avi Biopharma, Inc. |
Multiple exon skipping compositions for dmd
|
|
US8592386B2
(en)
*
|
2008-12-17 |
2013-11-26 |
Sarepta Therapeutics, Inc. |
Antisense compositions and methods for modulating contact hypersensitivity or contact dermatitis
|
|
EP2421971B1
(en)
|
2009-04-24 |
2016-07-06 |
BioMarin Technologies B.V. |
Oligonucleotide comprising an inosine for treating dmd
|
|
US20110269665A1
(en)
|
2009-06-26 |
2011-11-03 |
Avi Biopharma, Inc. |
Compound and method for treating myotonic dystrophy
|
|
KR102113306B1
(ko)
|
2009-11-12 |
2020-05-21 |
더 유니버시티 오브 웨스턴 오스트레일리아 |
안티센스 분자 및 이를 이용한 질환 치료방법
|
|
KR101944119B1
(ko)
|
2009-11-13 |
2019-01-30 |
사렙타 쎄러퓨틱스 인코퍼레이티드 |
안티센스 항바이러스 화합물 및 인플루엔자 바이러스 감염을 치료하는 방법
|
|
KR20120125455A
(ko)
*
|
2009-12-11 |
2012-11-15 |
광주과학기술원 |
세포내 타겟 결합용 바이포달 펩타이드 바인더
|
|
WO2011127210A1
(en)
*
|
2010-04-06 |
2011-10-13 |
Massachusetts Institute Of Technology |
Targeted delivery of nucleic acids
|
|
US9050373B2
(en)
|
2010-05-13 |
2015-06-09 |
The Charlotte-Mecklenburg Hospital Authority |
Pharmaceutical compositions comprising antisense oligonucleotides and methods of using same
|
|
KR102095478B1
(ko)
|
2010-05-28 |
2020-04-01 |
사렙타 쎄러퓨틱스, 인코퍼레이티드 |
변형된 서브유니트간 결합 및/또는 말단 그룹을 갖는 올리고뉴클레오타이드 유사체
|
|
JP5981428B2
(ja)
*
|
2010-07-19 |
2016-08-31 |
アイオーニス ファーマシューティカルズ, インコーポレーテッドIonis Pharmaceuticals,Inc. |
筋緊張性ジストロフィー・プロテインキナーゼ(dmpk)発現の調整
|
|
US8198429B2
(en)
|
2010-08-09 |
2012-06-12 |
Avi Biopharma, Inc. |
Antisense antiviral compounds and methods for treating a filovirus infection
|
|
CA2834128A1
(en)
*
|
2011-05-05 |
2012-11-08 |
Sarepta Therapeutics, Inc. |
Peptide oligonucleotide conjugates
|
|
US9161948B2
(en)
|
2011-05-05 |
2015-10-20 |
Sarepta Therapeutics, Inc. |
Peptide oligonucleotide conjugates
|
|
EP2750715B1
(en)
|
2011-08-30 |
2018-10-31 |
The Regents of The University of California |
Identification of small molecules that enhance therapeutic exon skipping
|
|
EP2751128B1
(en)
|
2011-08-30 |
2021-03-03 |
United Kingdom Research and Innovation |
Cell-penetrating peptides having a central hydrophobic domain
|
|
US20130085139A1
(en)
|
2011-10-04 |
2013-04-04 |
Royal Holloway And Bedford New College |
Oligomers
|
|
PT2581448E
(pt)
*
|
2011-10-13 |
2015-05-21 |
Institut National De La Santé Et De La Rech Médicale (Inserm) |
Dna triciclo-fosforotioato
|
|
SI2788487T1
(sl)
|
2011-12-08 |
2018-09-28 |
Sarepta Therapeutics, Inc. |
Analogi oligonukleotida, ki ciljajo humano LMNA
|
|
NZ627896A
(en)
|
2012-01-27 |
2016-11-25 |
Biomarin Technologies B V |
Rna modulating oligonucleotides with improved characteristics for the treatment of duchenne and becker muscular dystrophy
|
|
AU2013262709A1
(en)
|
2012-05-16 |
2015-01-22 |
Rana Therapeutics, Inc. |
Compositions and methods for modulating MECP2 expression
|
|
US10837014B2
(en)
|
2012-05-16 |
2020-11-17 |
Translate Bio Ma, Inc. |
Compositions and methods for modulating SMN gene family expression
|
|
US10059941B2
(en)
*
|
2012-05-16 |
2018-08-28 |
Translate Bio Ma, Inc. |
Compositions and methods for modulating SMN gene family expression
|
|
SG11201407486PA
(en)
*
|
2012-05-16 |
2014-12-30 |
Rana Therapeutics Inc |
Compositions and methods for modulating utrn expression
|
|
US10174323B2
(en)
|
2012-05-16 |
2019-01-08 |
The General Hospital Corporation |
Compositions and methods for modulating ATP2A2 expression
|
|
CN104583399A
(zh)
|
2012-05-16 |
2015-04-29 |
Rana医疗有限公司 |
用于调节血红蛋白基因家族表达的组合物和方法
|
|
KR101329411B1
(ko)
|
2012-05-31 |
2013-11-14 |
주식회사 엘지생활건강 |
피부투과성 펩타이드
|
|
CA2928851A1
(en)
|
2012-07-19 |
2014-01-23 |
Alethia Biotherapeutics Inc. |
Anti-siglec-15 antibodies
|
|
ES2941477T3
(es)
|
2012-08-13 |
2023-05-23 |
Univ Rockefeller |
Agonista de LXRbeta para el tratamiento de cáncer
|
|
MX369519B
(es)
|
2012-09-25 |
2019-11-11 |
Genzyme Corp |
Oligonucleotidos antisentido morfolino unidos a peptido para el tratamiento de distrofia miotonica.
|
|
NZ708171A
(en)
|
2012-11-15 |
2019-11-29 |
Roche Innovation Ct Copenhagen As |
Oligonucleotide conjugates
|
|
CN103981147B
(zh)
|
2013-02-08 |
2017-11-10 |
中国科学院上海生命科学研究院 |
一种新的制备肝实质细胞的方法
|
|
NZ731587A
(en)
|
2013-03-14 |
2021-07-30 |
Sarepta Therapeutics Inc |
Exon skipping compositions for treating muscular dystrophy
|
|
CN113633787A
(zh)
|
2013-03-15 |
2021-11-12 |
萨勒普塔医疗公司 |
改进的用于治疗肌营养不良的组合物
|
|
WO2015069586A2
(en)
|
2013-11-06 |
2015-05-14 |
Merck Sharp & Dohme Corp. |
Dual molecular delivery of oligonucleotides and peptide containing conjugates
|
|
US9790495B2
(en)
|
2014-05-16 |
2017-10-17 |
Oregon State University |
Antisense antibacterial compounds and methods
|
|
US10391098B2
(en)
|
2014-05-19 |
2019-08-27 |
Board Of Regents, The University Of Texas System |
Antisense antibacterial compounds and methods
|
|
TWI713450B
(zh)
|
2014-05-23 |
2020-12-21 |
美商健臻公司 |
藉由使用反義寡核苷酸創造提前終止密碼子抑制或下調肝醣合成酶
|
|
KR102487942B1
(ko)
|
2014-05-23 |
2023-01-11 |
젠자임 코포레이션 |
펩티드 담체 상의 다중 올리고뉴클레오티드 모이어티
|
|
AU2015372560B2
(en)
*
|
2014-12-31 |
2021-12-02 |
Board Of Regents, The University Of Texas System |
Antisense antibacterial compounds and methods
|
|
MA41795A
(fr)
*
|
2015-03-18 |
2018-01-23 |
Sarepta Therapeutics Inc |
Exclusion d'un exon induite par des composés antisens dans la myostatine
|
|
US11020417B2
(en)
|
2015-06-04 |
2021-06-01 |
Sarepta Therapeutics, Inc |
Methods and compounds for treatment of lymphocyte-related diseases and conditions
|
|
BR112018007066A2
(pt)
*
|
2015-10-09 |
2018-10-23 |
Sarepta Therapeutics Inc |
composições e métodos para tratamento da distrofia muscular de duchene e distúrbios relacionados
|
|
CA3009342A1
(en)
|
2015-12-23 |
2017-06-29 |
Board Of Regents, The University Of Texas System |
Antisense antibacterial compounds and methods
|
|
US10907158B2
(en)
|
2015-12-23 |
2021-02-02 |
Board Of Regents, The University Of Texas System |
Antisense antibacterial compounds and methods
|
|
MA45328A
(fr)
|
2016-04-01 |
2019-02-06 |
Avidity Biosciences Llc |
Compositions acide nucléique-polypeptide et utilisations de celles-ci
|
|
WO2017184529A1
(en)
|
2016-04-18 |
2017-10-26 |
Sarepta Therapeutics, Inc. |
Antisense oligomers and methods of using the same for treating diseases associated with the acid alpha-glucosidase gene
|
|
SG11201809468XA
(en)
|
2016-04-29 |
2018-11-29 |
Sarepta Therapeutics Inc |
Oligonucleotide analogues targeting human lmna
|
|
HRP20221316T1
(hr)
*
|
2016-12-19 |
2022-12-23 |
Sarepta Therapeutics, Inc. |
Oligomerni konjugati koji preskaču egzon za mišićnu distrofiju
|
|
PL3554553T3
(pl)
|
2016-12-19 |
2022-11-07 |
Sarepta Therapeutics, Inc. |
Koniugaty oligomerów z pominięciem egzonu w dystrofii mięśniowej
|
|
ES2928486T3
(es)
|
2016-12-19 |
2022-11-18 |
Sarepta Therapeutics Inc |
Conjugados de oligómeros con omisión de exón para la distrofia muscular
|
|
US10800817B2
(en)
*
|
2016-12-19 |
2020-10-13 |
Morehouse School Of Medicine |
Compositions and methods for treating diseases by inhibiting exosome release
|
|
SG10202107429WA
(en)
|
2017-01-06 |
2021-08-30 |
Avidity Biosciences Inc |
Nucleic acid-polypeptide compositions and methods of inducing exon skipping
|
|
US20180207293A1
(en)
*
|
2017-01-25 |
2018-07-26 |
2C Tech Corp. |
Nanoparticles for sustained ophthalmic drug delivery and methods of use
|
|
GB201711809D0
(en)
|
2017-07-21 |
2017-09-06 |
Governors Of The Univ Of Alberta |
Antisense oligonucleotide
|
|
JP2020536058A
(ja)
|
2017-09-28 |
2020-12-10 |
サレプタ セラピューティクス, インコーポレイテッド |
筋ジストロフィーを処置するための併用療法
|
|
EP3687547A1
(en)
|
2017-09-28 |
2020-08-05 |
Sarepta Therapeutics, Inc. |
Combination therapies for treating muscular dystrophy
|
|
JP2020536057A
(ja)
|
2017-09-28 |
2020-12-10 |
サレプタ セラピューティクス, インコーポレイテッド |
筋ジストロフィーを処置するための併用療法
|
|
WO2019079386A1
(en)
*
|
2017-10-17 |
2019-04-25 |
Sarepta Therapeutics, Inc. |
CELL PENETRATION PEPTIDES FOR ANTISENSE ADMINISTRATION
|
|
AU2018373028A1
(en)
|
2017-11-21 |
2020-04-30 |
Inspirna, Inc. |
Polymorphs and uses thereof
|
|
JP7013626B2
(ja)
*
|
2018-01-05 |
2022-02-01 |
国立医薬品食品衛生研究所長 |
細胞膜透過ペプチド、構築物、及び、カーゴ分子を細胞内に輸送する方法
|
|
EP3790890A4
(en)
|
2018-05-09 |
2022-03-02 |
Ohio State Innovation Foundation |
CYCLIC, CELL-PENETRATING PEPTIDES WITH ONE OR MORE HYDROPHOBIC RAILS
|
|
EP3806868A4
(en)
|
2018-06-13 |
2022-06-22 |
Sarepta Therapeutics, Inc. |
EXON SKIPPING OLIGOMERS FOR MUSCULAR DYSTROPHY
|
|
TW202020153A
(zh)
|
2018-07-27 |
2020-06-01 |
美商薩羅塔治療公司 |
用於肌肉萎縮症之外顯子跳躍寡聚物
|
|
US12097263B2
(en)
|
2018-08-02 |
2024-09-24 |
Dyne Therapeutics, Inc. |
Muscle targeting complexes and uses thereof for treating myotonic dystrophy
|
|
KR20210081323A
(ko)
*
|
2018-08-02 |
2021-07-01 |
다인 세라퓨틱스, 인크. |
근육 표적화 복합체 및 근긴장성 이영양증을 치료하기 위한 그의 용도
|
|
US12370264B1
(en)
|
2018-08-02 |
2025-07-29 |
Dyne Therapeutics, Inc. |
Complexes comprising an anti-transferrin receptor antibody linked to an oligonucleotide and method of delivering oligonucleotide to a subject
|
|
US12018087B2
(en)
|
2018-08-02 |
2024-06-25 |
Dyne Therapeutics, Inc. |
Muscle-targeting complexes comprising an anti-transferrin receptor antibody linked to an oligonucleotide and methods of delivering oligonucleotide to a subject
|
|
GB201812972D0
(en)
|
2018-08-09 |
2018-09-26 |
Univ Oxford Innovation Ltd |
Cell-penetrating peptides
|
|
GB201812980D0
(en)
|
2018-08-09 |
2018-09-26 |
Univ Oxford Innovation Ltd |
Cell-penetrating peptides
|
|
CN113453723A
(zh)
|
2018-12-07 |
2021-09-28 |
牛津大学科技创新有限公司 |
接头
|
|
AU2019397461A1
(en)
|
2018-12-13 |
2021-07-29 |
Sarepta Therapeutics, Inc. |
Exon skipping oligomer conjugates for muscular dystrophy
|
|
GB201821269D0
(en)
|
2018-12-28 |
2019-02-13 |
Nippon Shinyaku Co Ltd |
Myostatin signal inhibitor
|
|
WO2020214763A1
(en)
|
2019-04-18 |
2020-10-22 |
Sarepta Therapeutics, Inc. |
Compositions for treating muscular dystrophy
|
|
GB201911403D0
(en)
*
|
2019-08-09 |
2019-09-25 |
Univ Oxford Innovation Ltd |
Conjugate and uses thereof
|
|
KR102270700B1
(ko)
*
|
2019-11-01 |
2021-06-30 |
한국과학기술연구원 |
폐 섬유증의 예방 또는 치료를 위한 올리고뉴클레오티드 중합체와 생체 적합성 양이온성 펩타이드로 이루어지는 폐 특이적 약물 전달체 및 이의 이용
|
|
HUE067466T2
(hu)
|
2019-12-13 |
2024-10-28 |
Inspirna Inc |
Fémsók és alkalmazásuk
|
|
CN114901823A
(zh)
|
2019-12-26 |
2022-08-12 |
日本新药株式会社 |
诱导外显子50的跳读的反义核酸
|
|
JPWO2021172498A1
(enExample)
|
2020-02-28 |
2021-09-02 |
|
|
|
US11987795B2
(en)
|
2020-11-24 |
2024-05-21 |
The Broad Institute, Inc. |
Methods of modulating SLC7A11 pre-mRNA transcripts for diseases and conditions associated with expression of SLC7A11
|
|
US20240327831A1
(en)
|
2020-12-23 |
2024-10-03 |
Sarepta Therapeutics, Inc. |
Compositions comprising exon skipping oligonucleotide conjugates for treating muscular dystrophy
|
|
EP4330395A1
(en)
|
2021-04-30 |
2024-03-06 |
Sarepta Therapeutics, Inc. |
Treatment methods for muscular dystrophy
|
|
US12378267B2
(en)
|
2021-06-17 |
2025-08-05 |
Entrada Therapeutics, Inc. |
Synthesis of FMOC-protected morpholino monomers and oligomers
|
|
AU2022298028A1
(en)
|
2021-06-23 |
2023-12-21 |
National Center Of Neurology And Psychiatry |
Combination of antisense oligomers
|
|
TW202308664A
(zh)
|
2021-07-08 |
2023-03-01 |
日商日本新藥股份有限公司 |
腎毒性減輕劑
|
|
CN118475355A
(zh)
|
2021-07-08 |
2024-08-09 |
日本新药株式会社 |
肾毒性减轻剂
|
|
US20240285770A1
(en)
|
2021-07-08 |
2024-08-29 |
Nippon Shinyaku Co., Ltd. |
Precipitation suppressing agent
|
|
US11969475B2
(en)
|
2021-07-09 |
2024-04-30 |
Dyne Therapeutics, Inc. |
Muscle targeting complexes and uses thereof for treating facioscapulohumeral muscular dystrophy
|
|
EP4387676A2
(en)
*
|
2021-09-03 |
2024-06-26 |
Sarepta Therapeutics, Inc. |
Delivery of anitsense oligomers by mirror image peptides
|
|
AU2023235302A1
(en)
|
2022-03-17 |
2024-10-24 |
Sarepta Therapeutics, Inc. |
Phosphorodiamidate morpholino oligomer conjugates
|
|
CN119183457A
(zh)
|
2022-04-15 |
2024-12-24 |
达因疗法公司 |
用于治疗强直性肌营养不良的肌肉靶向复合物和制剂
|
|
US20250289851A1
(en)
|
2022-04-22 |
2025-09-18 |
Entrada Therapeutics, Inc. |
Cyclic peptides for delivering therapeutics
|
|
WO2024091824A1
(en)
|
2022-10-26 |
2024-05-02 |
Ada Forsyth Institute, Inc. |
Differentiation and reprogramming of chondrocyte
|
|
EP4612292A1
(en)
|
2022-11-02 |
2025-09-10 |
Sarepta Therapeutics, Inc. |
Formulation of an antisense oligomer conjugate
|
|
WO2024129459A1
(en)
|
2022-12-16 |
2024-06-20 |
University Of Rochester |
Repairmen! of barrier dysfunction in esophagus
|
|
WO2025085868A2
(en)
|
2023-10-20 |
2025-04-24 |
Radiation Control Technologies, Inc. |
Cd47-targeting morpholinos
|