|
AU2003225410A1
(en)
*
|
2003-03-21 |
2004-10-11 |
Academisch Ziekenhuis Leiden |
Modulation of exon recognition in pre-mrna by interfering with the secondary rna structure
|
|
EP1629105B1
(en)
*
|
2003-04-29 |
2010-09-01 |
AVI BioPharma, Inc. |
Compositions for enhancing transport and antisense efficacy of nucleic acid analog into cells
|
|
US20050222068A1
(en)
*
|
2003-10-23 |
2005-10-06 |
Mourich Dan V |
Method and antisense composition for selective inhibition of HIV infection in hematopoietic cells
|
|
US20050234002A1
(en)
*
|
2004-01-23 |
2005-10-20 |
Mourich Dan V |
Antisense oligomers and methods for inducing immune tolerance and immunosuppression
|
|
US20050288246A1
(en)
|
2004-05-24 |
2005-12-29 |
Iversen Patrick L |
Peptide conjugated, inosine-substituted antisense oligomer compound and method
|
|
PL1766010T3
(pl)
|
2004-06-28 |
2011-07-29 |
Univ Western Australia |
Antysensowne oligonukleotydy do indukcji pominięcia egzonu i sposoby ich zastosowania
|
|
US8129352B2
(en)
|
2004-09-16 |
2012-03-06 |
Avi Biopharma, Inc. |
Antisense antiviral compound and method for treating ssRNA viral infection
|
|
AU2006213686A1
(en)
*
|
2005-02-09 |
2006-08-17 |
Avi Bio Pharma, Inc. |
Antisense composition and method for treating muscle atrophy
|
|
US8067571B2
(en)
|
2005-07-13 |
2011-11-29 |
Avi Biopharma, Inc. |
Antibacterial antisense oligonucleotide and method
|
|
WO2007030691A2
(en)
*
|
2005-09-08 |
2007-03-15 |
Avi Biopharma, Inc. |
Antisense antiviral compound and method for treating picornavirus infection
|
|
US8168181B2
(en)
|
2006-02-13 |
2012-05-01 |
Alethia Biotherapeutics, Inc. |
Methods of impairing osteoclast differentiation using antibodies that bind siglec-15
|
|
CA2822302A1
(en)
|
2006-02-13 |
2007-08-23 |
Alethia Biotherapeutics Inc. |
Methods of impairing osteoclast differentiation
|
|
US8785407B2
(en)
*
|
2006-05-10 |
2014-07-22 |
Sarepta Therapeutics, Inc. |
Antisense antiviral agent and method for treating ssRNA viral infection
|
|
US20100016215A1
(en)
*
|
2007-06-29 |
2010-01-21 |
Avi Biopharma, Inc. |
Compound and method for treating myotonic dystrophy
|
|
EP2203173B1
(en)
|
2007-10-26 |
2015-12-23 |
Academisch Ziekenhuis Leiden |
Means and methods for counteracting muscle disorders
|
|
AU2008345033B2
(en)
*
|
2007-12-28 |
2014-04-03 |
Sarepta Therapeutics, Inc. |
Immunomodulatory agents and methods of use
|
|
EP2119783A1
(en)
|
2008-05-14 |
2009-11-18 |
Prosensa Technologies B.V. |
Method for efficient exon (44) skipping in Duchenne Muscular Dystrophy and associated means
|
|
US8231895B2
(en)
*
|
2008-05-22 |
2012-07-31 |
Universidade De Coimbra |
Targeted delivery to human diseases and disorders
|
|
US20110130346A1
(en)
*
|
2008-05-30 |
2011-06-02 |
Isis Innovation Limited |
Peptide conjugates for delvery of biologically active compounds
|
|
EP2283029A1
(en)
*
|
2008-06-04 |
2011-02-16 |
Medical Research Council |
Peptides
|
|
US8084601B2
(en)
|
2008-09-11 |
2011-12-27 |
Royal Holloway And Bedford New College Royal Holloway, University Of London |
Oligomers
|
|
CN105779453A
(zh)
|
2008-10-24 |
2016-07-20 |
萨雷普塔治疗公司 |
用于dmd的多外显子跳跃组合物
|
|
US8592386B2
(en)
*
|
2008-12-17 |
2013-11-26 |
Sarepta Therapeutics, Inc. |
Antisense compositions and methods for modulating contact hypersensitivity or contact dermatitis
|
|
EP2421971B1
(en)
|
2009-04-24 |
2016-07-06 |
BioMarin Technologies B.V. |
Oligonucleotide comprising an inosine for treating dmd
|
|
US20110269665A1
(en)
|
2009-06-26 |
2011-11-03 |
Avi Biopharma, Inc. |
Compound and method for treating myotonic dystrophy
|
|
BR122023023194A2
(pt)
|
2009-11-12 |
2023-12-26 |
The University Of Western Australia |
Oligonucleotídeo antissentido, composição e respectivo uso
|
|
JP5991922B2
(ja)
|
2009-11-13 |
2016-09-14 |
サレプタ セラピューティクス, インコーポレイテッド |
アンチセンス抗ウイルス性化合物およびインフルエンザウイルス感染を処置するための方法
|
|
KR20120125455A
(ko)
*
|
2009-12-11 |
2012-11-15 |
광주과학기술원 |
세포내 타겟 결합용 바이포달 펩타이드 바인더
|
|
WO2011127210A1
(en)
*
|
2010-04-06 |
2011-10-13 |
Massachusetts Institute Of Technology |
Targeted delivery of nucleic acids
|
|
US9050373B2
(en)
*
|
2010-05-13 |
2015-06-09 |
The Charlotte-Mecklenburg Hospital Authority |
Pharmaceutical compositions comprising antisense oligonucleotides and methods of using same
|
|
KR102182663B1
(ko)
|
2010-05-28 |
2020-11-25 |
사렙타 쎄러퓨틱스, 인코퍼레이티드 |
변형된 서브유니트간 결합 및/또는 말단 그룹을 갖는 올리고뉴클레오타이드 유사체
|
|
EP3489360A3
(en)
*
|
2010-07-19 |
2019-08-28 |
Ionis Pharmaceuticals, Inc. |
Modulation of nuclear-retained rna
|
|
US8198429B2
(en)
|
2010-08-09 |
2012-06-12 |
Avi Biopharma, Inc. |
Antisense antiviral compounds and methods for treating a filovirus infection
|
|
US9161948B2
(en)
|
2011-05-05 |
2015-10-20 |
Sarepta Therapeutics, Inc. |
Peptide oligonucleotide conjugates
|
|
IL273838B
(en)
*
|
2011-05-05 |
2022-09-01 |
Sarepta Therapeutics Inc |
Peptide and oligonucleotide conjugates, preparations containing them and their uses
|
|
AU2012300633B2
(en)
|
2011-08-30 |
2017-04-27 |
United Kingdom Research And Innovation |
Cell- penetrating peptides having a central hydrophobic domain
|
|
EP2750715B1
(en)
|
2011-08-30 |
2018-10-31 |
The Regents of The University of California |
Identification of small molecules that enhance therapeutic exon skipping
|
|
US20130085139A1
(en)
|
2011-10-04 |
2013-04-04 |
Royal Holloway And Bedford New College |
Oligomers
|
|
EP2581448B1
(en)
*
|
2011-10-13 |
2015-01-28 |
Association Institut de Myologie |
Tricyclo-phosphorothioate DNA
|
|
WO2013086441A2
(en)
|
2011-12-08 |
2013-06-13 |
Sarepta Therapeutics, Inc. |
Oligonucleotide analogues targeting human lmna
|
|
CN118581086A
(zh)
*
|
2012-01-27 |
2024-09-03 |
比奥马林技术公司 |
用于治疗杜兴型肌营养不良症和贝克型肌营养不良症的具有改善特性的rna调节性寡核苷酸
|
|
EA201492121A1
(ru)
|
2012-05-16 |
2015-10-30 |
Рана Терапьютикс, Инк. |
Композиции и способы для модулирования экспрессии семейства генов гемоглобина
|
|
AU2013262709A1
(en)
|
2012-05-16 |
2015-01-22 |
Rana Therapeutics, Inc. |
Compositions and methods for modulating MECP2 expression
|
|
US10837014B2
(en)
|
2012-05-16 |
2020-11-17 |
Translate Bio Ma, Inc. |
Compositions and methods for modulating SMN gene family expression
|
|
JP2015523853A
(ja)
|
2012-05-16 |
2015-08-20 |
ラナ セラピューティクス インコーポレイテッド |
Atp2a2発現を調節するための組成物及び方法
|
|
KR20150030205A
(ko)
*
|
2012-05-16 |
2015-03-19 |
라나 테라퓨틱스, 인크. |
Smn 유전자 패밀리 발현을 조절하기 위한 조성물 및 방법
|
|
SG11201407486PA
(en)
*
|
2012-05-16 |
2014-12-30 |
Rana Therapeutics Inc |
Compositions and methods for modulating utrn expression
|
|
KR101329411B1
(ko)
*
|
2012-05-31 |
2013-11-14 |
주식회사 엘지생활건강 |
피부투과성 펩타이드
|
|
ES2723885T3
(es)
|
2012-07-19 |
2019-09-03 |
Daiichi Sankyo Co Ltd |
Anticuerpos anti-Siglec-15
|
|
ES2765573T3
(es)
|
2012-08-13 |
2020-06-09 |
Univ Rockefeller |
Tratamiento y diagnóstico de melanoma
|
|
KR102240217B1
(ko)
|
2012-09-25 |
2021-04-14 |
젠자임 코포레이션 |
근긴장성 이영양증의 치료용 펩티드-결합 모르폴리노 안티센스 올리고뉴클레오티드
|
|
SG10201804331TA
(en)
|
2012-11-15 |
2018-07-30 |
Roche Innovation Ct Copenhagen As |
Oligonucleotide conjugates
|
|
CN103981147B
(zh)
|
2013-02-08 |
2017-11-10 |
中国科学院上海生命科学研究院 |
一种新的制备肝实质细胞的方法
|
|
EA202090946A3
(ru)
|
2013-03-14 |
2021-07-30 |
Сарепта Терапьютикс, Инк. |
Композиции, обеспечивающие пропускание экзонов, для лечения мышечной дистрофии
|
|
NZ631289A
(en)
|
2013-03-15 |
2017-08-25 |
Sarepta Therapeutics Inc |
Improved compositions for treating muscular dystrophy
|
|
WO2015069586A2
(en)
|
2013-11-06 |
2015-05-14 |
Merck Sharp & Dohme Corp. |
Dual molecular delivery of oligonucleotides and peptide containing conjugates
|
|
CA2948373A1
(en)
|
2014-05-16 |
2015-11-19 |
Oregon State University |
Antisense antibacterial compounds and methods
|
|
EP3569252B1
(en)
|
2014-05-19 |
2021-12-15 |
Oregon State University |
Antisense antibacterial compounds and methods
|
|
EP3146050B1
(en)
|
2014-05-23 |
2020-08-12 |
Genzyme Corporation |
Inhibiting or downregulating glycogen synthase by creating premature stop codons using antisense oligonucleotides
|
|
JP6825914B2
(ja)
|
2014-05-23 |
2021-02-03 |
ジェンザイム・コーポレーション |
ペプチド担体上の多重オリゴヌクレオチド部分
|
|
CA3249464A1
(en)
*
|
2014-12-31 |
2025-11-29 |
Univ Texas |
Antisense antibacterial compounds and methods
|
|
MA41795A
(fr)
*
|
2015-03-18 |
2018-01-23 |
Sarepta Therapeutics Inc |
Exclusion d'un exon induite par des composés antisens dans la myostatine
|
|
US11020417B2
(en)
|
2015-06-04 |
2021-06-01 |
Sarepta Therapeutics, Inc |
Methods and compounds for treatment of lymphocyte-related diseases and conditions
|
|
WO2017062835A2
(en)
*
|
2015-10-09 |
2017-04-13 |
Sarepta Therapeutics, Inc. |
Compositions and methods for treating duchenne muscular dystrophy and related disorders
|
|
JP7393121B2
(ja)
*
|
2015-12-23 |
2023-12-06 |
オレゴン ステイト ユニバーシティー |
アンチセンス抗菌化合物および方法
|
|
US10907158B2
(en)
|
2015-12-23 |
2021-02-02 |
Board Of Regents, The University Of Texas System |
Antisense antibacterial compounds and methods
|
|
KR102775461B1
(ko)
|
2016-04-01 |
2025-02-28 |
어비디티 바이오사이언시스 인크. |
핵산-폴리펩타이드 조성물 및 이의 용도
|
|
MY200252A
(en)
|
2016-04-18 |
2023-12-16 |
Sarepta Therapeutics Inc |
Antisense oligomers and methods of using the same for treating diseases associated with the acid alpha-glucosidase gene
|
|
WO2017190041A1
(en)
|
2016-04-29 |
2017-11-02 |
Sarepta Therapeutics, Inc. |
Oligonucleotide analogues targeting human lmna
|
|
CN117298290A
(zh)
*
|
2016-12-19 |
2023-12-29 |
萨勒普塔医疗公司 |
用于肌肉萎缩症的外显子跳跃寡聚体缀合物
|
|
LT3554553T
(lt)
|
2016-12-19 |
2022-08-25 |
Sarepta Therapeutics, Inc. |
Egzoną šalinantys oligomero konjugatai nuo raumenų distrofojos
|
|
US10800817B2
(en)
|
2016-12-19 |
2020-10-13 |
Morehouse School Of Medicine |
Compositions and methods for treating diseases by inhibiting exosome release
|
|
EP3554552B1
(en)
|
2016-12-19 |
2022-08-17 |
Sarepta Therapeutics, Inc. |
Exon skipping oligomer conjugates for muscular dystrophy
|
|
CN110381980A
(zh)
|
2017-01-06 |
2019-10-25 |
艾维迪提生物科学有限责任公司 |
核酸-多肽组合物以及诱导外显子跳读的方法
|
|
US20180207293A1
(en)
*
|
2017-01-25 |
2018-07-26 |
2C Tech Corp. |
Nanoparticles for sustained ophthalmic drug delivery and methods of use
|
|
US20200131231A1
(en)
|
2017-02-17 |
2020-04-30 |
Oxford University Innovation Limited |
Cell penetrating peptides
|
|
GB201711809D0
(en)
|
2017-07-21 |
2017-09-06 |
Governors Of The Univ Of Alberta |
Antisense oligonucleotide
|
|
JP2020536057A
(ja)
|
2017-09-28 |
2020-12-10 |
サレプタ セラピューティクス, インコーポレイテッド |
筋ジストロフィーを処置するための併用療法
|
|
JP2020536060A
(ja)
|
2017-09-28 |
2020-12-10 |
サレプタ セラピューティクス, インコーポレイテッド |
筋ジストロフィーを処置するための併用療法
|
|
EP3687577A1
(en)
|
2017-09-28 |
2020-08-05 |
Sarepta Therapeutics, Inc. |
Combination therapies for treating muscular dystrophy
|
|
TW202423453A
(zh)
*
|
2017-10-17 |
2024-06-16 |
美商薩羅塔治療公司 |
用於反義遞送之細胞穿透肽
|
|
AU2018373028A1
(en)
|
2017-11-21 |
2020-04-30 |
Inspirna, Inc. |
Polymorphs and uses thereof
|
|
JP7013626B2
(ja)
*
|
2018-01-05 |
2022-02-01 |
国立医薬品食品衛生研究所長 |
細胞膜透過ペプチド、構築物、及び、カーゴ分子を細胞内に輸送する方法
|
|
WO2019217682A1
(en)
|
2018-05-09 |
2019-11-14 |
Ohio State Innovation Foundation |
Cyclic cell-penetrating peptides with one or more hydrophobic residues
|
|
EP3806868A4
(en)
|
2018-06-13 |
2022-06-22 |
Sarepta Therapeutics, Inc. |
EXON SKIPPING OLIGOMERS FOR MUSCULAR DYSTROPHY
|
|
TW202020153A
(zh)
|
2018-07-27 |
2020-06-01 |
美商薩羅塔治療公司 |
用於肌肉萎縮症之外顯子跳躍寡聚物
|
|
CA3108287A1
(en)
*
|
2018-08-02 |
2020-02-06 |
Dyne Therapeutics, Inc. |
Muscle targeting complexes and uses thereof for treating myotonic dystrophy
|
|
US12097263B2
(en)
|
2018-08-02 |
2024-09-24 |
Dyne Therapeutics, Inc. |
Muscle targeting complexes and uses thereof for treating myotonic dystrophy
|
|
US12370264B1
(en)
|
2018-08-02 |
2025-07-29 |
Dyne Therapeutics, Inc. |
Complexes comprising an anti-transferrin receptor antibody linked to an oligonucleotide and method of delivering oligonucleotide to a subject
|
|
US12018087B2
(en)
|
2018-08-02 |
2024-06-25 |
Dyne Therapeutics, Inc. |
Muscle-targeting complexes comprising an anti-transferrin receptor antibody linked to an oligonucleotide and methods of delivering oligonucleotide to a subject
|
|
GB201812980D0
(en)
|
2018-08-09 |
2018-09-26 |
Univ Oxford Innovation Ltd |
Cell-penetrating peptides
|
|
GB201812972D0
(en)
|
2018-08-09 |
2018-09-26 |
Univ Oxford Innovation Ltd |
Cell-penetrating peptides
|
|
US12465646B2
(en)
|
2018-12-07 |
2025-11-11 |
Oxford University Innovation Limited |
Linkers
|
|
IL321667A
(en)
|
2018-12-13 |
2025-08-01 |
Sarepta Therapeutics Inc |
Exon skipping oligomer conjugates for muscular dystrophy
|
|
GB201821269D0
(en)
|
2018-12-28 |
2019-02-13 |
Nippon Shinyaku Co Ltd |
Myostatin signal inhibitor
|
|
US20220193246A1
(en)
|
2019-04-18 |
2022-06-23 |
Sarepta Therapeutics, Inc. |
Compositions for treating muscular dystrophy
|
|
GB201911403D0
(en)
*
|
2019-08-09 |
2019-09-25 |
Univ Oxford Innovation Ltd |
Conjugate and uses thereof
|
|
KR102270700B1
(ko)
*
|
2019-11-01 |
2021-06-30 |
한국과학기술연구원 |
폐 섬유증의 예방 또는 치료를 위한 올리고뉴클레오티드 중합체와 생체 적합성 양이온성 펩타이드로 이루어지는 폐 특이적 약물 전달체 및 이의 이용
|
|
EP4073025B1
(en)
|
2019-12-13 |
2024-03-27 |
Inspirna, Inc. |
Metal salts and uses thereof
|
|
CA3165961A1
(en)
|
2019-12-26 |
2021-07-01 |
Nippon Shinyaku Co., Ltd. |
Antisense nucleic acid that induces skipping of exon 50
|
|
AU2021226089A1
(en)
|
2020-02-28 |
2022-09-15 |
National Center Of Neurology And Psychiatry |
Antisense nucleic acid inducing skipping of exon 51
|
|
US11987795B2
(en)
|
2020-11-24 |
2024-05-21 |
The Broad Institute, Inc. |
Methods of modulating SLC7A11 pre-mRNA transcripts for diseases and conditions associated with expression of SLC7A11
|
|
JP2024501800A
(ja)
|
2020-12-23 |
2024-01-16 |
サレプタ セラピューティクス, インコーポレイテッド |
筋ジストロフィーを治療するためのエクソンスキッピングオリゴヌクレオチドコンジュゲートを含む組成物
|
|
CA3216839A1
(en)
|
2021-04-30 |
2022-11-03 |
Sarepta Therapeutics, Inc. |
Treatment methods for muscular dystrophy
|
|
US12378267B2
(en)
|
2021-06-17 |
2025-08-05 |
Entrada Therapeutics, Inc. |
Synthesis of FMOC-protected morpholino monomers and oligomers
|
|
AU2022298028A1
(en)
|
2021-06-23 |
2023-12-21 |
National Center Of Neurology And Psychiatry |
Combination of antisense oligomers
|
|
JPWO2023282346A1
(enExample)
|
2021-07-08 |
2023-01-12 |
|
|
|
EP4368186A4
(en)
|
2021-07-08 |
2025-06-25 |
Nippon Shinyaku Co., Ltd. |
NEPHROTOXICITY REDUCING AGENT
|
|
TW202308664A
(zh)
|
2021-07-08 |
2023-03-01 |
日商日本新藥股份有限公司 |
腎毒性減輕劑
|
|
US11969475B2
(en)
|
2021-07-09 |
2024-04-30 |
Dyne Therapeutics, Inc. |
Muscle targeting complexes and uses thereof for treating facioscapulohumeral muscular dystrophy
|
|
US20250011777A1
(en)
*
|
2021-09-03 |
2025-01-09 |
Sarepta Therapeutics, Inc. |
Delivery of anitsense oligomers by mirror image peptides
|
|
JP2025509438A
(ja)
|
2022-03-17 |
2025-04-11 |
サレプタ セラピューティクス, インコーポレイテッド |
ホスホロジアミデートモルホリノオリゴマーコンジュゲート
|
|
KR20250004770A
(ko)
|
2022-04-15 |
2025-01-08 |
다인 세라퓨틱스, 인크. |
근긴장성 이영양증을 치료하기 위한 근육 표적화 복합체 및 제제
|
|
WO2023205451A1
(en)
|
2022-04-22 |
2023-10-26 |
Entrada Therapeutics, Inc. |
Cyclic peptides for delivering therapeutics
|
|
WO2024091824A1
(en)
|
2022-10-26 |
2024-05-02 |
Ada Forsyth Institute, Inc. |
Differentiation and reprogramming of chondrocyte
|
|
EP4612292A1
(en)
|
2022-11-02 |
2025-09-10 |
Sarepta Therapeutics, Inc. |
Formulation of an antisense oligomer conjugate
|
|
WO2024129459A1
(en)
|
2022-12-16 |
2024-06-20 |
University Of Rochester |
Repairmen! of barrier dysfunction in esophagus
|
|
WO2025085868A2
(en)
|
2023-10-20 |
2025-04-24 |
Radiation Control Technologies, Inc. |
Cd47-targeting morpholinos
|
|
WO2026080471A2
(en)
|
2024-10-07 |
2026-04-16 |
Flagship Pioneering Innovations Vi, Llc |
Compositions of trem conjugates and uses thereof
|