RS51447B - Konjugati i postupci za njihovu proizvodnju, i njihova upotreba za transport molekula kroz biološke membrane - Google Patents

Konjugati i postupci za njihovu proizvodnju, i njihova upotreba za transport molekula kroz biološke membrane

Info

Publication number
RS51447B
RS51447B YUP-903/01A YUP90301A RS51447B RS 51447 B RS51447 B RS 51447B YU P90301 A YUP90301 A YU P90301A RS 51447 B RS51447 B RS 51447B
Authority
RS
Serbia
Prior art keywords
conjugates
production
methods
biological membranes
molecules via
Prior art date
Application number
YUP-903/01A
Other languages
English (en)
Inventor
Eugen Uhlmann
Beate Greiner
Eberhard Unger
Gislinde Gothe
Marc Schwerdel
Original Assignee
Sanofi- Aventis Deutschland Gmbh.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sanofi- Aventis Deutschland Gmbh. filed Critical Sanofi- Aventis Deutschland Gmbh.
Priority to MEP-564/08A priority Critical patent/MEP56408A/xx
Publication of YU90301A publication Critical patent/YU90301A/sh
Publication of RS51447B publication Critical patent/RS51447B/sr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
    • A61K47/542—Carboxylic acids, e.g. a fatty acid or an amino acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
    • A61P31/22—Antivirals for DNA viruses for herpes viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Virology (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Pulmonology (AREA)
  • Epidemiology (AREA)
  • Plant Pathology (AREA)
  • Microbiology (AREA)
  • Dermatology (AREA)
  • Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Biophysics (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Ophthalmology & Optometry (AREA)
  • AIDS & HIV (AREA)

Abstract

Upotreba aril radikala formula F1 i F3 do F11,za koji je vezan molekul koji treba transportovati, a odabran je iz grupe koju čine polinukleotid, oligonukleotid i mononukleotida, za transport molekula kroz biološke membrane in vitro.Prijava sadrži još 8 patentnih zahteva.
YUP-903/01A 1999-07-28 2000-07-20 Konjugati i postupci za njihovu proizvodnju, i njihova upotreba za transport molekula kroz biološke membrane RS51447B (sr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
MEP-564/08A MEP56408A (en) 1999-07-28 2000-07-20 Conjugates and methods for the production thereof, and their use for transporting molecules via biological membranes

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19935302A DE19935302A1 (de) 1999-07-28 1999-07-28 Konjugate und Verfahren zu deren Herstellung sowie deren Verwendung zum Transport von Molekülen über biologische Membranen

Publications (2)

Publication Number Publication Date
YU90301A YU90301A (sh) 2004-05-12
RS51447B true RS51447B (sr) 2011-04-30

Family

ID=7916258

Family Applications (2)

Application Number Title Priority Date Filing Date
RSP-2010/0249A RS20100249A (en) 1999-07-28 2000-07-20 CONJUGATES AND PROCEDURES FOR THEIR PRODUCTION, AND THEIR USE FOR THE TRANSPORT OF MOLECULES THROUGH BIOLOGICAL MEMBRANE
YUP-903/01A RS51447B (sr) 1999-07-28 2000-07-20 Konjugati i postupci za njihovu proizvodnju, i njihova upotreba za transport molekula kroz biološke membrane

Family Applications Before (1)

Application Number Title Priority Date Filing Date
RSP-2010/0249A RS20100249A (en) 1999-07-28 2000-07-20 CONJUGATES AND PROCEDURES FOR THEIR PRODUCTION, AND THEIR USE FOR THE TRANSPORT OF MOLECULES THROUGH BIOLOGICAL MEMBRANE

Country Status (33)

Country Link
US (1) US8420396B2 (sr)
EP (1) EP1204430B1 (sr)
JP (1) JP4791665B2 (sr)
KR (1) KR100721696B1 (sr)
CN (1) CN1227035C (sr)
AR (1) AR029385A1 (sr)
AT (1) ATE447413T1 (sr)
AU (1) AU776114B2 (sr)
BR (1) BR0012757A (sr)
CA (1) CA2377977C (sr)
CY (1) CY1109744T1 (sr)
CZ (1) CZ2002300A3 (sr)
DE (2) DE19935302A1 (sr)
DK (1) DK1204430T3 (sr)
EE (1) EE05303B1 (sr)
ES (1) ES2335741T3 (sr)
HK (1) HK1047042A1 (sr)
HR (1) HRP20020074B1 (sr)
HU (1) HUP0201995A3 (sr)
IL (2) IL147527A0 (sr)
ME (1) MEP56408A (sr)
MX (1) MXPA01013114A (sr)
NO (1) NO334155B1 (sr)
NZ (1) NZ516838A (sr)
PL (1) PL202881B1 (sr)
PT (1) PT1204430E (sr)
RS (2) RS20100249A (sr)
RU (1) RU2275936C2 (sr)
SI (1) SI1204430T1 (sr)
SK (1) SK287654B6 (sr)
TR (4) TR201109491T2 (sr)
WO (1) WO2001008707A2 (sr)
ZA (1) ZA200200657B (sr)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20030129251A1 (en) * 2000-03-10 2003-07-10 Gary Van Nest Biodegradable immunomodulatory formulations and methods for use thereof
US7026166B2 (en) * 2002-01-22 2006-04-11 Chiron Corporation Fluorogenic dyes
US7704756B2 (en) 2003-01-21 2010-04-27 Novartis Vaccines And Diagnostics, Inc. Fluorogenic dyes
US20070167388A1 (en) * 2003-09-11 2007-07-19 Universitätsklinikum Schleswig-Holstein Campus Lübeck Nucleotide sequences promoting the trans-membrane transport of nucleic acids
JP4989225B2 (ja) * 2003-09-25 2012-08-01 コーリー ファーマシューティカル グループ，インコーポレイテッド 核酸親油性接合体
EP1886681A3 (en) * 2004-10-07 2008-11-19 Sulfidris S.r.l. 5-(p-hydroxyphenyl)-3H-1,2-dithiol-3-thione valproate ester
KR100690199B1 (ko) * 2006-04-20 2007-03-12 이화여자대학교 산학협력단 구리 이온 선택성을 갖는 플루오레세인 유도체, 이의제조방법 및 이를 이용한 생체 내 구리 이온 검출방법
RU2010112771A (ru) * 2007-10-09 2011-11-20 Коули Фармасьютикал ГмбХ (DE) Иммуностимулирующие аналоги олигонуклеотидов, содержащие модифицированные сахарные группировки
ES2605990T3 (es) 2010-12-29 2017-03-17 F. Hoffmann-La Roche Ag Conjugados de molécula pequeña para la administración intracelular de ácidos nucleicos
SG11201608880VA (en) 2014-05-23 2016-11-29 Genzyme Corp Multiple oligonucleotide moieties on peptide carrier
US20180036312A1 (en) * 2016-08-02 2018-02-08 ISI Life Sciences Inc. Novel Scaffolds for Intracellular Compound Delivery for the Detection of Cancer Cells
EP3493855A4 (en) 2016-08-02 2020-04-01 ISI Life Sciences, Inc. METHOD FOR DETECTION OF CANCER CELLS.
US10753942B2 (en) 2017-05-15 2020-08-25 Indicator Systems International, Inc. Methods to detect remnant cancer cells
US10539567B2 (en) * 2017-05-15 2020-01-21 Indicator Systems International, Inc. Biopsy methods and devices
KR20230096856A (ko) 2021-12-22 2023-06-30 한국과학기술연구원 신규 펩타이드-올리고뉴클레오티드 접합체 및 이의 용도

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE8801070D0 (sv) 1988-03-23 1988-03-23 Pharmacia Ab Method for immobilizing a dna sequence on a solid support
WO1995006659A1 (en) * 1992-07-01 1995-03-09 Isis Pharmaceuticals, Inc. Amine-derivatized nucleosides and oligonucleosides
US6228982B1 (en) 1992-05-22 2001-05-08 Benget Norden Double-stranded peptide nucleic acids
US6335434B1 (en) 1998-06-16 2002-01-01 Isis Pharmaceuticals, Inc., Nucleosidic and non-nucleosidic folate conjugates
US6033909A (en) 1992-01-22 2000-03-07 Hoechst Aktiengesellschaft Oligonucleotide analogs, their preparation and use
IL104461A (en) 1992-01-22 2001-05-20 Hoechst Ag Analogs of oligonucleotide, their preparation and pharmaceutical preparations containing them
US5633360A (en) * 1992-04-14 1997-05-27 Gilead Sciences, Inc. Oligonucleotide analogs capable of passive cell membrane permeation
US5820873A (en) 1994-09-30 1998-10-13 The University Of British Columbia Polyethylene glycol modified ceramide lipids and liposome uses thereof
DE19502912A1 (de) 1995-01-31 1996-08-01 Hoechst Ag G-Cap Stabilisierte Oligonucleotide
US5698411A (en) 1995-05-18 1997-12-16 Coulter Corporation Method for determining activity of enzymes in metabolically active whole cells
WO1998020887A1 (en) * 1996-11-14 1998-05-22 Brigham And Women's Hospital, Inc. Polyphosphoinositide binding peptides for intracellular drug delivery
GB9809084D0 (en) 1998-04-28 1998-06-24 Nycomed Imaging As Improvements in or relating to diagnostic/therapeutic agents
DE19824535A1 (de) * 1998-06-03 1999-12-09 Roche Diagnostics Gmbh Neue Rhodamin-Derivate und deren Verwendung
US6335432B1 (en) 1998-08-07 2002-01-01 Bio-Red Laboratories, Inc. Structural analogs of amine bases and nucleosides
US6080580A (en) 1998-10-05 2000-06-27 Isis Pharmaceuticals Inc. Antisense oligonucleotide modulation of tumor necrosis factor-α (TNF-α) expression
AU5376500A (en) 1999-06-17 2001-01-09 Universiteit Gent Functional poly-alpha-aminoacid derivatives useful for the modification of biologically active materials and their application

Also Published As

Publication number Publication date
IL147527A (en) 2006-08-01
IL147527A0 (en) 2002-08-14
DE50015781D1 (de) 2009-12-17
BR0012757A (pt) 2002-04-02
MXPA01013114A (es) 2002-06-04
TR201109493T2 (tr) 2012-03-21
PL202881B1 (pl) 2009-07-31
JP2003505517A (ja) 2003-02-12
SK1172002A3 (en) 2002-08-06
ES2335741T3 (es) 2010-04-05
DK1204430T3 (da) 2010-03-29
ZA200200657B (en) 2003-09-23
WO2001008707A3 (de) 2001-11-08
AU776114B2 (en) 2004-08-26
SK287654B6 (sk) 2011-05-06
CA2377977A1 (en) 2001-02-08
TR200706709T2 (tr) 2008-02-21
HRP20020074B1 (en) 2011-01-31
EP1204430A2 (de) 2002-05-15
NO334155B1 (no) 2013-12-23
YU90301A (sh) 2004-05-12
CZ2002300A3 (cs) 2002-05-15
HUP0201995A3 (en) 2005-02-28
RU2275936C2 (ru) 2006-05-10
CN1227035C (zh) 2005-11-16
EP1204430B1 (de) 2009-11-04
KR20020031392A (ko) 2002-05-01
AR029385A1 (es) 2003-06-25
JP4791665B2 (ja) 2011-10-12
WO2001008707A2 (de) 2001-02-08
NO20020367D0 (no) 2002-01-23
CN1360507A (zh) 2002-07-24
US20080071069A1 (en) 2008-03-20
SI1204430T1 (sl) 2010-03-31
HRP20020074A2 (en) 2005-10-31
CA2377977C (en) 2011-09-20
HK1047042A1 (en) 2003-02-07
TR200200222T2 (tr) 2002-07-22
ATE447413T1 (de) 2009-11-15
TR201109491T2 (tr) 2012-02-21
RS20100249A (en) 2011-02-28
NZ516838A (en) 2004-07-30
PT1204430E (pt) 2010-01-26
HUP0201995A2 (en) 2002-10-28
KR100721696B1 (ko) 2007-05-28
MEP56408A (en) 2011-05-10
PL353069A1 (en) 2003-10-06
US8420396B2 (en) 2013-04-16
NO20020367L (no) 2002-03-26
EE05303B1 (et) 2010-06-15
EE200200035A (et) 2003-04-15
DE19935302A1 (de) 2001-02-08
CY1109744T1 (el) 2014-09-10
AU6825200A (en) 2001-02-19

Similar Documents

Publication Publication Date Title
RS51447B (sr) Konjugati i postupci za njihovu proizvodnju, i njihova upotreba za transport molekula kroz biološke membrane
BR0109636A (pt) Benzoilpirazóis e sua aplicação como herbicidas
BRPI0413022A (pt) derivados de 3-amino cromado e 2-amino tetralina
BR0111981A (pt) herbicidas de piridina substituìda
DK1150577T3 (da) Forbedrede mikrobepræparater
HUP0301948A2 (hu) Guanidin-sókon alapuló biocid polimerek
BR0107770A (pt) Derivados de 3-fenóxi-1-fenil acetileno e seu uso como herbicidas
DE60211119D1 (de) Kultivierung von crypthecodinium cohnii und abstammenden microorganismen
MA31567B1 (fr) Derives de 7 -alkynyl-1.8-naphthyrid0nes, leur preparation et leur application en therapeutique
DE69901569D1 (de) Humane antikörper gegen faktor ix/ixa
DK1289629T3 (da) Mikrofiltrering under anvendelse af aktivt kul
CN103409370B (zh) 一种用于淋巴细胞培养的培养基及应用
BR0102991A (pt) Método de produzir exopolissacarìdeos, caldo de fermentação, exopolissacarìdeo, e, bactéria
SE9602809D0 (sv) Basic azo compounds, their production and use
ATE384092T1 (de) Integration von sicherheitspartikeln in wertdokumenten und wertprodukten
BR0108409A (pt) Derivados de aminoácidos e sua utilização como inibidores da nep, da ace e da ece
ATE333288T1 (de) Gezielte freisetzung von arzneimitteln zur behandlung von virusinfektionen
PT1053345E (pt) Processo para a producao de bacatina
RS52237B (sr) Rastvor za peritonealnu dijalizu koji sadrži karnitin i ima poboljšanu biokompatibilnost
DK1539976T3 (da) Fremgangsmåde til fremstilling af biologisk nedbrydelige, funktionaliserede polymerpartikler og deres anvendelse som lægemiddelbærere
BR0014443A (pt) Aril cetonas substituìdas
DE602005003922D1 (de) Synthese von spongosin
Sarza An Ugly Book Tasting: Jane Forsey & Lars Aagaard-Mogensen (Eds.)“On the Ugly: Aesthetic Exchanges”
DE60132466D1 (de) Verfahren zur kultivierung von menschlichen lungenmastzellen und deren anwendungen
BR0208732A (pt) Derivados de benzoilciclohexandionas e seu uso como herbicidas