JP2018513668A5 - - Google Patents
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- JP2018513668A5 JP2018513668A5 JP2017534286A JP2017534286A JP2018513668A5 JP 2018513668 A5 JP2018513668 A5 JP 2018513668A5 JP 2017534286 A JP2017534286 A JP 2017534286A JP 2017534286 A JP2017534286 A JP 2017534286A JP 2018513668 A5 JP2018513668 A5 JP 2018513668A5
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- 108020004707 nucleic acids Proteins 0.000 claims 18
- 102000039446 nucleic acids Human genes 0.000 claims 18
- 150000007523 nucleic acids Chemical class 0.000 claims 18
- 230000000692 anti-sense effect Effects 0.000 claims 12
- 239000002773 nucleotide Substances 0.000 claims 8
- 125000003729 nucleotide group Chemical group 0.000 claims 8
- 108091081021 Sense strand Proteins 0.000 claims 6
- 230000000295 complement effect Effects 0.000 claims 5
- 108020004999 messenger RNA Proteins 0.000 claims 5
- 101000944380 Homo sapiens Cyclin-dependent kinase inhibitor 1 Proteins 0.000 claims 3
- 102000049765 human CDKN1A Human genes 0.000 claims 3
- 239000004055 small Interfering RNA Substances 0.000 claims 3
- 108091032973 (ribonucleotides)n+m Proteins 0.000 claims 2
- 108091007412 Piwi-interacting RNA Proteins 0.000 claims 2
- 108020004459 Small interfering RNA Proteins 0.000 claims 2
- 230000030279 gene silencing Effects 0.000 claims 2
- 238000012226 gene silencing method Methods 0.000 claims 2
- 108091033319 polynucleotide Proteins 0.000 claims 2
- 102000040430 polynucleotide Human genes 0.000 claims 2
- 239000002157 polynucleotide Substances 0.000 claims 2
- DRTQHJPVMGBUCF-UHFFFAOYSA-N uracil arabinoside Natural products OC1C(O)C(CO)OC1N1C(=O)NC(=O)C=C1 DRTQHJPVMGBUCF-UHFFFAOYSA-N 0.000 claims 2
- 102000040650 (ribonucleotides)n+m Human genes 0.000 claims 1
- 108091030071 RNAI Proteins 0.000 claims 1
- 108091027967 Small hairpin RNA Proteins 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 230000009368 gene silencing by RNA Effects 0.000 claims 1
- 230000002401 inhibitory effect Effects 0.000 claims 1
- 125000003473 lipid group Chemical group 0.000 claims 1
- 239000002502 liposome Substances 0.000 claims 1
- 108091070501 miRNA Proteins 0.000 claims 1
- 239000002679 microRNA Substances 0.000 claims 1
- 239000002924 silencing RNA Substances 0.000 claims 1
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2014266198 | 2014-12-26 | ||
| JP2014266198 | 2014-12-26 | ||
| US201562184209P | 2015-06-24 | 2015-06-24 | |
| US62/184,209 | 2015-06-24 | ||
| US201562266668P | 2015-12-13 | 2015-12-13 | |
| US62/266,668 | 2015-12-13 | ||
| PCT/US2015/067556 WO2016106401A2 (en) | 2014-12-26 | 2015-12-28 | Rna agents for p21 gene modulation |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2018513668A JP2018513668A (ja) | 2018-05-31 |
| JP2018513668A5 true JP2018513668A5 (enExample) | 2019-02-14 |
| JP6793649B2 JP6793649B2 (ja) | 2020-12-02 |
Family
ID=56151549
Family Applications (10)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017534294A Active JP6730285B2 (ja) | 2014-12-26 | 2015-12-28 | Ｒｎａ干渉組成物及び悪性腫瘍のための方法 |
| JP2017534275A Pending JP2018512373A (ja) | 2014-12-26 | 2015-12-28 | Ｋｒａｓ突然変異に関連する悪性腫瘍に対する治療のための方法及び組成物 |
| JP2017534297A Active JP6457645B2 (ja) | 2014-12-26 | 2015-12-28 | ＧＳＴ−π遺伝子を調節するためのＲＮＡ干渉剤 |
| JP2017534287A Pending JP2018513669A (ja) | 2014-12-26 | 2015-12-28 | Ｇｓｔ−ｐｉ遺伝子調節のためのｒｎａ剤 |
| JP2017534286A Active JP6793649B2 (ja) | 2014-12-26 | 2015-12-28 | Ｐ２１遺伝子調節のためのｒｎａ剤 |
| JP2017534274A Pending JP2018513104A (ja) | 2014-12-26 | 2015-12-28 | Ｈｓｐ４７及びｐ２１を標的とするｒｎａｉ分子による悪性腫瘍の治療用組成物及び方法 |
| JP2017534279A Active JP6865169B2 (ja) | 2014-12-26 | 2015-12-28 | Ｐ２１遺伝子調節のためのｒｎａ干渉剤 |
| JP2021183788A Active JP7307137B2 (ja) | 2014-12-26 | 2021-11-11 | ＧＳＴ－π遺伝子を調節するためのＲＮＡ干渉剤 |
| JP2023106970A Active JP7655971B2 (ja) | 2014-12-26 | 2023-06-29 | ＧＳＴ－π遺伝子を調節するためのＲＮＡ干渉剤 |
| JP2025046972A Pending JP2025102833A (ja) | 2014-12-26 | 2025-03-21 | ＧＳＴ－π遺伝子を調節するためのＲＮＡ干渉剤 |
Family Applications Before (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017534294A Active JP6730285B2 (ja) | 2014-12-26 | 2015-12-28 | Ｒｎａ干渉組成物及び悪性腫瘍のための方法 |
| JP2017534275A Pending JP2018512373A (ja) | 2014-12-26 | 2015-12-28 | Ｋｒａｓ突然変異に関連する悪性腫瘍に対する治療のための方法及び組成物 |
| JP2017534297A Active JP6457645B2 (ja) | 2014-12-26 | 2015-12-28 | ＧＳＴ−π遺伝子を調節するためのＲＮＡ干渉剤 |
| JP2017534287A Pending JP2018513669A (ja) | 2014-12-26 | 2015-12-28 | Ｇｓｔ−ｐｉ遺伝子調節のためのｒｎａ剤 |
Family Applications After (5)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017534274A Pending JP2018513104A (ja) | 2014-12-26 | 2015-12-28 | Ｈｓｐ４７及びｐ２１を標的とするｒｎａｉ分子による悪性腫瘍の治療用組成物及び方法 |
| JP2017534279A Active JP6865169B2 (ja) | 2014-12-26 | 2015-12-28 | Ｐ２１遺伝子調節のためのｒｎａ干渉剤 |
| JP2021183788A Active JP7307137B2 (ja) | 2014-12-26 | 2021-11-11 | ＧＳＴ－π遺伝子を調節するためのＲＮＡ干渉剤 |
| JP2023106970A Active JP7655971B2 (ja) | 2014-12-26 | 2023-06-29 | ＧＳＴ－π遺伝子を調節するためのＲＮＡ干渉剤 |
| JP2025046972A Pending JP2025102833A (ja) | 2014-12-26 | 2025-03-21 | ＧＳＴ－π遺伝子を調節するためのＲＮＡ干渉剤 |
Country Status (10)
| Country | Link |
|---|---|
| US (14) | US10264976B2 (enExample) |
| EP (9) | EP3236969A4 (enExample) |
| JP (10) | JP6730285B2 (enExample) |
| KR (4) | KR20170093988A (enExample) |
| CN (7) | CN108064153A (enExample) |
| AU (4) | AU2015369595A1 (enExample) |
| BR (2) | BR112017013597B1 (enExample) |
| CA (4) | CA2972268A1 (enExample) |
| RU (4) | RU2719185C2 (enExample) |
| WO (7) | WO2016106400A2 (enExample) |
Families Citing this family (36)
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| US11045488B2 (en) * | 2014-12-26 | 2021-06-29 | Nitto Denko Corporation | RNA interference agents for GST-π gene modulation |
| US20180002702A1 (en) | 2014-12-26 | 2018-01-04 | Nitto Denko Corporation | Methods and compositions for treating malignant tumors associated with kras mutation |
| ES2789049T3 (es) * | 2014-12-26 | 2020-10-23 | Nitto Denko Corp | Agentes de interferencia de ARN para modulación génica de GST-pi |
| US10792299B2 (en) | 2014-12-26 | 2020-10-06 | Nitto Denko Corporation | Methods and compositions for treating malignant tumors associated with kras mutation |
| US10264976B2 (en) * | 2014-12-26 | 2019-04-23 | The University Of Akron | Biocompatible flavonoid compounds for organelle and cell imaging |
| EP3686184A3 (en) * | 2015-06-24 | 2020-08-26 | Nitto Denko Corporation | Ionizable compounds and compositions and uses thereof |
| CA3005937C (en) | 2015-12-13 | 2021-11-09 | Nitto Denko Corporation | Sirna structures for high activity and reduced off target |
| CN109477146B (zh) | 2016-05-10 | 2023-09-19 | 国立大学法人东京医科齿科大学 | 炎症促进因子表达抑制剂、其有效成分的筛选方法、对该方法有用的表达盒、诊断药和诊断方法 |
| WO2018151840A2 (en) * | 2017-02-16 | 2018-08-23 | Nitto Denko Corporation | Methods and compositions for treating malignant tumors |
| AU2018359904B2 (en) | 2017-11-06 | 2023-02-23 | Nitto Denko Corporation | Fusogenic compounds for delivery of biologically active molecules |
| AU2018364001A1 (en) | 2017-11-09 | 2020-06-25 | National University Corporation Tokyo Medical And Dental University | Inhibitor of the expression of cancer-promoting factors, screening method for active ingredient thereof, expression cassette useful in said method, diagnostic drug, and diagnostic method |
| CN109777798A (zh) * | 2017-11-13 | 2019-05-21 | 深圳华大生命科学研究院 | 一种基于CRISPR技术治疗KRAS突变恶性肿瘤的sgRNA及其应用 |
| JP6952594B2 (ja) * | 2017-12-15 | 2021-10-20 | 洋司郎 新津 | 細胞増殖抑制剤及びそれを含むがんの治療若しくは予防用医薬組成物 |
| CN108486011B (zh) * | 2018-03-27 | 2020-05-05 | 山东大学 | 一种三联苯化合物、制备方法及其应用 |
| JP7432929B2 (ja) * | 2018-05-31 | 2024-02-19 | コリア ユニバーシティ リサーチ アンド ビジネス ファウンデーション | マイクロｒｎａの非正規標的を抑制するｒｎａ干渉誘導核酸およびその用途 |
| WO2020009189A1 (ja) * | 2018-07-05 | 2020-01-09 | 洋司郎 新津 | Ｂｒａｆ阻害剤によるがん細胞の逆説的増殖を抑制する薬剤 |
| WO2020040186A1 (ja) | 2018-08-22 | 2020-02-27 | 日東電工株式会社 | Ｈｓｐ４７の阻害物質を用いた、がん転移抑制 |
| EP3848050A4 (en) * | 2018-08-22 | 2022-06-08 | Nitto Denko Corporation | DRUG USING AN HSP47 INHIBITOR TO INCREASE SENSITIVITY TO A CHEMOTHERAPY DRUG |
| JP7667077B2 (ja) * | 2018-11-16 | 2025-04-22 | 日東電工株式会社 | Ｒｎａ干渉送達製剤及び悪性腫瘍のための方法 |
| US20220016156A1 (en) * | 2018-12-05 | 2022-01-20 | Nitto Denko Corporation | Rnai molecule for treating cancer |
| JP7373807B2 (ja) | 2019-01-10 | 2023-11-06 | 国立大学法人大阪大学 | 免疫賦活用組成物 |
| WO2020196736A1 (ja) * | 2019-03-28 | 2020-10-01 | 日東電工株式会社 | ＲＮＡｉ分子 |
| JP2019116507A (ja) * | 2019-04-25 | 2019-07-18 | 有限会社オービット | Ｈｓｐ４７の発現促進剤、脱毛抑制方法、Ｈｓｐ４７の発現促進剤の製造方法及び飲食物の製造方法 |
| US20230027604A1 (en) * | 2019-07-02 | 2023-01-26 | Argonaute RNA Limited | Apolipoprotein b antagonist |
| EP4005602A4 (en) * | 2019-07-30 | 2024-06-12 | Shionogi & Co., Ltd | NUCLEIC ACID AGENT TARGETED AGAINST MURF1 |
| US20230061751A1 (en) * | 2020-01-17 | 2023-03-02 | University Of Massachusetts | Universal dynamic pharmacokinetic-modifying anchors |
| CN112280800B (zh) * | 2020-10-19 | 2022-06-07 | 上海市东方医院（同济大学附属东方医院） | 一种构建体及其在制备动物衰老细胞示踪和衰老细胞清除药物中的应用 |
| AU2021416356A1 (en) | 2020-12-28 | 2023-08-10 | 1E Therapeutics, Ltd. | P21 mrna targeting dnazymes |
| AU2021411103B2 (en) * | 2020-12-28 | 2025-04-24 | 1E Therapeutics, Ltd. | P21 mrna target areas for silencing |
| KR102732913B1 (ko) * | 2021-12-29 | 2024-11-20 | 의료법인 명지의료재단 | K-ras 특이적 활성화 T 세포를 포함하는 흑색종의 예방 및 치료용 약제학적 조성물 및 이의 제조방법 |
| KR102732910B1 (ko) * | 2021-12-29 | 2024-11-20 | 의료법인 명지의료재단 | K-ras 특이적 활성화 T 세포를 포함하는 대장암의 예방 및 치료용 약제학적 조성물 및 이의 제조방법 |
| KR102732912B1 (ko) * | 2021-12-29 | 2024-11-20 | 의료법인 명지의료재단 | K-ras 특이적 활성화 T 세포를 포함하는 폐 선암종의 예방 및 치료용 약제학적 조성물 및 이의 제조방법 |
| KR102732911B1 (ko) * | 2021-12-29 | 2024-11-20 | 의료법인 명지의료재단 | K-ras 특이적 활성화 T 세포를 포함하는 유방암의 예방 및 치료용 약제학적 조성물 및 이의 제조방법 |
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