JP2013226147A5 - - Google Patents
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- JP2013226147A5 JP2013226147A5 JP2013115737A JP2013115737A JP2013226147A5 JP 2013226147 A5 JP2013226147 A5 JP 2013226147A5 JP 2013115737 A JP2013115737 A JP 2013115737A JP 2013115737 A JP2013115737 A JP 2013115737A JP 2013226147 A5 JP2013226147 A5 JP 2013226147A5
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- Prior art keywords
- pharmaceutical composition
- nucleotides
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- modified
- Prior art date
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- 239000008194 pharmaceutical composition Substances 0.000 claims 11
- 125000003729 nucleotide group Chemical group 0.000 claims 9
- 108091034117 Oligonucleotide Proteins 0.000 claims 8
- 239000002773 nucleotide Substances 0.000 claims 7
- 101001030705 Homo sapiens Huntingtin Proteins 0.000 claims 2
- 239000000074 antisense oligonucleotide Substances 0.000 claims 2
- 238000012230 antisense oligonucleotides Methods 0.000 claims 2
- 230000000295 complement effect Effects 0.000 claims 2
- OPTASPLRGRRNAP-UHFFFAOYSA-N cytosine Chemical compound NC=1C=CNC(=O)N=1 OPTASPLRGRRNAP-UHFFFAOYSA-N 0.000 claims 2
- 102000054185 human HTT Human genes 0.000 claims 2
- 108020004707 nucleic acids Proteins 0.000 claims 2
- 102000039446 nucleic acids Human genes 0.000 claims 2
- YIMATHOGWXZHFX-WCTZXXKLSA-N (2r,3r,4r,5r)-5-(hydroxymethyl)-3-(2-methoxyethoxy)oxolane-2,4-diol Chemical group COCCO[C@H]1[C@H](O)O[C@H](CO)[C@H]1O YIMATHOGWXZHFX-WCTZXXKLSA-N 0.000 claims 1
- LRSASMSXMSNRBT-UHFFFAOYSA-N 5-methylcytosine Chemical group CC1=CNC(=O)N=C1N LRSASMSXMSNRBT-UHFFFAOYSA-N 0.000 claims 1
- 241000282412 Homo Species 0.000 claims 1
- 208000023105 Huntington disease Diseases 0.000 claims 1
- 230000000692 anti-sense effect Effects 0.000 claims 1
- -1 bicyclic nucleic acid Chemical class 0.000 claims 1
- 229940104302 cytosine Drugs 0.000 claims 1
- 125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 claims 1
- 150000007523 nucleic acids Chemical class 0.000 claims 1
- RYYWUUFWQRZTIU-UHFFFAOYSA-K thiophosphate Chemical compound [O-]P([O-])([O-])=S RYYWUUFWQRZTIU-UHFFFAOYSA-K 0.000 claims 1
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US76295406P | 2006-01-26 | 2006-01-26 | |
| US60/762,954 | 2006-01-26 | ||
| US83629006P | 2006-08-07 | 2006-08-07 | |
| US60/836,290 | 2006-08-07 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008552447A Division JP5425474B2 (ja) | 2006-01-26 | 2007-01-26 | ハンチンチン対する、組成物及びその使用 |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015252875A Division JP6395058B2 (ja) | 2006-01-26 | 2015-12-25 | ハンチンチン対する、組成物及びその使用 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2013226147A JP2013226147A (ja) | 2013-11-07 |
| JP2013226147A5 true JP2013226147A5 (enExample) | 2014-03-13 |
| JP5916660B2 JP5916660B2 (ja) | 2016-05-11 |
Family
ID=38164262
Family Applications (5)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008552447A Active JP5425474B2 (ja) | 2006-01-26 | 2007-01-26 | ハンチンチン対する、組成物及びその使用 |
| JP2013115737A Active JP5916660B2 (ja) | 2006-01-26 | 2013-05-31 | ハンチンチン対する、組成物及びその使用 |
| JP2015252875A Active JP6395058B2 (ja) | 2006-01-26 | 2015-12-25 | ハンチンチン対する、組成物及びその使用 |
| JP2018061748A Pending JP2018117635A (ja) | 2006-01-26 | 2018-03-28 | ハンチンチン対する、組成物及びその使用 |
| JP2020023793A Pending JP2020096624A (ja) | 2006-01-26 | 2020-02-14 | ハンチンチン対する、組成物及びその使用 |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008552447A Active JP5425474B2 (ja) | 2006-01-26 | 2007-01-26 | ハンチンチン対する、組成物及びその使用 |
Family Applications After (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015252875A Active JP6395058B2 (ja) | 2006-01-26 | 2015-12-25 | ハンチンチン対する、組成物及びその使用 |
| JP2018061748A Pending JP2018117635A (ja) | 2006-01-26 | 2018-03-28 | ハンチンチン対する、組成物及びその使用 |
| JP2020023793A Pending JP2020096624A (ja) | 2006-01-26 | 2020-02-14 | ハンチンチン対する、組成物及びその使用 |
Country Status (11)
| Country | Link |
|---|---|
| US (14) | US20070299027A1 (enExample) |
| EP (5) | EP2161038B1 (enExample) |
| JP (5) | JP5425474B2 (enExample) |
| AU (4) | AU2007210038B2 (enExample) |
| CA (1) | CA2638908C (enExample) |
| DK (1) | DK2161038T3 (enExample) |
| ES (2) | ES2453380T3 (enExample) |
| PL (2) | PL3210633T3 (enExample) |
| PT (1) | PT2161038E (enExample) |
| SI (1) | SI2161038T1 (enExample) |
| WO (2) | WO2007089611A2 (enExample) |
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| WO2008134646A2 (en) | 2007-04-26 | 2008-11-06 | University Of Iowa Research Foundation | Rna interference suppression of neurodegenerative diseases and methods of use thereof |
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