JP2012228254A5 - - Google Patents
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- JP2012228254A5 JP2012228254A5 JP2012150997A JP2012150997A JP2012228254A5 JP 2012228254 A5 JP2012228254 A5 JP 2012228254A5 JP 2012150997 A JP2012150997 A JP 2012150997A JP 2012150997 A JP2012150997 A JP 2012150997A JP 2012228254 A5 JP2012228254 A5 JP 2012228254A5
- Authority
- JP
- Japan
- Prior art keywords
- cancer cells
- sequence
- mirna inhibitor
- cancer cell
- modification
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- 238000000034 method Methods 0.000 claims 16
- 239000003112 inhibitor Substances 0.000 claims 12
- 108091070501 miRNA Proteins 0.000 claims 10
- 239000002679 microRNA Substances 0.000 claims 10
- 206010028980 Neoplasm Diseases 0.000 claims 9
- 201000011510 cancer Diseases 0.000 claims 9
- 238000012986 modification Methods 0.000 claims 8
- 230000004048 modification Effects 0.000 claims 8
- 239000002773 nucleotide Substances 0.000 claims 6
- 125000003729 nucleotide group Chemical group 0.000 claims 6
- 206010006187 Breast cancer Diseases 0.000 claims 4
- 208000026310 Breast neoplasm Diseases 0.000 claims 4
- 206010009944 Colon cancer Diseases 0.000 claims 4
- 206010058467 Lung neoplasm malignant Diseases 0.000 claims 4
- 108091034117 Oligonucleotide Proteins 0.000 claims 4
- 208000024770 Thyroid neoplasm Diseases 0.000 claims 4
- 208000029742 colonic neoplasm Diseases 0.000 claims 4
- 230000000295 complement effect Effects 0.000 claims 4
- 201000005202 lung cancer Diseases 0.000 claims 4
- 208000020816 lung neoplasm Diseases 0.000 claims 4
- 108091062762 miR-21 stem-loop Proteins 0.000 claims 4
- 108091041631 miR-21-1 stem-loop Proteins 0.000 claims 4
- 108091044442 miR-21-2 stem-loop Proteins 0.000 claims 4
- 201000002510 thyroid cancer Diseases 0.000 claims 4
- 230000002401 inhibitory effect Effects 0.000 claims 2
- 238000011191 terminal modification Methods 0.000 claims 2
- 230000010261 cell growth Effects 0.000 claims 1
- 230000004663 cell proliferation Effects 0.000 claims 1
Applications Claiming Priority (6)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US62717104P | 2004-11-12 | 2004-11-12 | |
| US60/627,171 | 2004-11-12 | ||
| US64963405P | 2005-02-03 | 2005-02-03 | |
| US60/649,634 | 2005-02-03 | ||
| US68373605P | 2005-05-23 | 2005-05-23 | |
| US60/683,736 | 2005-05-23 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010036925A Division JP5389690B2 (ja) | 2004-11-12 | 2010-02-23 | miRNAおよびmiRNA阻害分子に関する方法および組成物 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2012228254A JP2012228254A (ja) | 2012-11-22 |
| JP2012228254A5 true JP2012228254A5 (enExample) | 2013-06-27 |
| JP5596085B2 JP5596085B2 (ja) | 2014-09-24 |
Family
ID=37570916
Family Applications (11)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2007541398A Pending JP2008519606A (ja) | 2004-11-12 | 2005-11-14 | miRNAおよびmiRNA阻害分子に関する方法および組成物 |
| JP2010036925A Expired - Fee Related JP5389690B2 (ja) | 2004-11-12 | 2010-02-23 | miRNAおよびmiRNA阻害分子に関する方法および組成物 |
| JP2012150997A Expired - Fee Related JP5596085B2 (ja) | 2004-11-12 | 2012-07-05 | miRNAおよびmiRNA阻害分子に関する方法および組成物 |
| JP2013183871A Expired - Fee Related JP5620556B2 (ja) | 2004-11-12 | 2013-09-05 | miRNAおよびmiRNA阻害分子に関する方法および組成物 |
| JP2014107664A Pending JP2014217381A (ja) | 2004-11-12 | 2014-05-26 | miRNAおよびmiRNA阻害分子に関する方法および組成物 |
| JP2014150321A Pending JP2014217384A (ja) | 2004-11-12 | 2014-07-24 | miRNAおよびmiRNA阻害分子に関する方法および組成物 |
| JP2014150365A Pending JP2014223080A (ja) | 2004-11-12 | 2014-07-24 | miRNAおよびmiRNA阻害分子に関する方法および組成物 |
| JP2014150384A Pending JP2014217386A (ja) | 2004-11-12 | 2014-07-24 | miRNAおよびmiRNA阻害分子に関する方法および組成物 |
| JP2014150414A Pending JP2014217387A (ja) | 2004-11-12 | 2014-07-24 | miRNAおよびmiRNA阻害分子に関する方法および組成物 |
| JP2014150350A Pending JP2014217385A (ja) | 2004-11-12 | 2014-07-24 | miRNAおよびmiRNA阻害分子に関する方法および組成物 |
| JP2016069966A Pending JP2016165292A (ja) | 2004-11-12 | 2016-03-31 | miRNAおよびmiRNA阻害分子に関する方法および組成物 |
Family Applications Before (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2007541398A Pending JP2008519606A (ja) | 2004-11-12 | 2005-11-14 | miRNAおよびmiRNA阻害分子に関する方法および組成物 |
| JP2010036925A Expired - Fee Related JP5389690B2 (ja) | 2004-11-12 | 2010-02-23 | miRNAおよびmiRNA阻害分子に関する方法および組成物 |
Family Applications After (8)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013183871A Expired - Fee Related JP5620556B2 (ja) | 2004-11-12 | 2013-09-05 | miRNAおよびmiRNA阻害分子に関する方法および組成物 |
| JP2014107664A Pending JP2014217381A (ja) | 2004-11-12 | 2014-05-26 | miRNAおよびmiRNA阻害分子に関する方法および組成物 |
| JP2014150321A Pending JP2014217384A (ja) | 2004-11-12 | 2014-07-24 | miRNAおよびmiRNA阻害分子に関する方法および組成物 |
| JP2014150365A Pending JP2014223080A (ja) | 2004-11-12 | 2014-07-24 | miRNAおよびmiRNA阻害分子に関する方法および組成物 |
| JP2014150384A Pending JP2014217386A (ja) | 2004-11-12 | 2014-07-24 | miRNAおよびmiRNA阻害分子に関する方法および組成物 |
| JP2014150414A Pending JP2014217387A (ja) | 2004-11-12 | 2014-07-24 | miRNAおよびmiRNA阻害分子に関する方法および組成物 |
| JP2014150350A Pending JP2014217385A (ja) | 2004-11-12 | 2014-07-24 | miRNAおよびmiRNA阻害分子に関する方法および組成物 |
| JP2016069966A Pending JP2016165292A (ja) | 2004-11-12 | 2016-03-31 | miRNAおよびmiRNA阻害分子に関する方法および組成物 |
Country Status (11)
| Country | Link |
|---|---|
| US (25) | US8173611B2 (enExample) |
| EP (21) | EP2314688B1 (enExample) |
| JP (11) | JP2008519606A (enExample) |
| AU (1) | AU2005333165B2 (enExample) |
| CA (7) | CA2857879A1 (enExample) |
| DK (1) | DK2302055T3 (enExample) |
| ES (13) | ES2534303T3 (enExample) |
| HK (1) | HK1204656A1 (enExample) |
| PL (1) | PL2302055T3 (enExample) |
| SI (1) | SI2302055T1 (enExample) |
| WO (1) | WO2006137941A2 (enExample) |
Families Citing this family (409)
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| EP2390328A1 (en) | 2001-09-28 | 2011-11-30 | Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. | MicroRNA molecules |
| EP2290071B1 (en) | 2004-05-28 | 2014-12-31 | Asuragen, Inc. | Methods and compositions involving microRNA |
| WO2006027776A1 (en) * | 2004-09-07 | 2006-03-16 | Yissum Research Development Company Of The Hebrew University Of Jerusalem | Agents, compositions and methods for treating pathologies in which regulating an ache-associated biological pathway is beneficial |
| US7642348B2 (en) * | 2004-10-04 | 2010-01-05 | Rosetta Genomics Ltd | Prostate cancer-related nucleic acids |
| US20090186353A1 (en) * | 2004-10-04 | 2009-07-23 | Rosetta Genomics Ltd. | Cancer-related nucleic acids |
| US7825229B2 (en) * | 2005-03-25 | 2010-11-02 | Rosetta Genomics Ltd. | Lung cancer-related nucleic acids |
| EP2314688B1 (en) | 2004-11-12 | 2014-07-16 | Asuragen, Inc. | Methods and compositions involving miRNA and miRNA inhibitor molecules |
| WO2006107826A2 (en) | 2005-04-04 | 2006-10-12 | The Board Of Regents Of The University Of Texas System | Micro-rna's that regulate muscle cells |
| EP1883709A4 (en) | 2005-04-29 | 2010-10-13 | Univ Rockefeller | HUMAN MICRO-RNAS AND METHOD OF INHIBITING THEM |
| EP1904111A4 (en) * | 2005-06-03 | 2009-08-19 | Univ Johns Hopkins | COMPOSITIONS AND METHODS FOR REDUCING MICRORNA EXPRESSION FOR THE TREATMENT OF NEOPLASIA |
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| AU2016203848B2 (en) * | 2006-01-05 | 2017-12-14 | The Ohio State University Research Foundation | MicroRNA-based methods and compositions for the diagnosis, prognosis and treatment of lung cancer |
| EP2369012A1 (en) | 2006-03-20 | 2011-09-28 | The Ohio State University Research Foundation | Micro-RNA fingerprints during human megakaryocytopoiesis |
| US8163708B2 (en) | 2006-04-03 | 2012-04-24 | Santaris Pharma A/S | Pharmaceutical composition comprising anti-mirna antisense oligonucleotide |
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| CA2657030A1 (en) | 2006-07-13 | 2008-01-17 | The Ohio State University Research Foundation, An Instrumentality Of The State Of Ohio | Micro-rna-based methods and compositions for the diagnosis and treatment of colon cancer-related diseases |
| EP2434017A3 (en) | 2006-08-01 | 2012-09-05 | Board of Regents of the University of Texas System | Identification of a micro-RNA that activates expression of beta-myosin heavy chain |
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- 2005-11-14 CA CA2857880A patent/CA2857880A1/en not_active Abandoned
- 2005-11-14 EP EP10183611.2A patent/EP2281889B1/en not_active Expired - Lifetime
- 2005-11-14 EP EP10183538.7A patent/EP2287303B1/en not_active Expired - Lifetime
- 2005-11-14 US US11/273,640 patent/US8173611B2/en not_active Expired - Fee Related
- 2005-11-14 EP EP10183470A patent/EP2298893A1/en not_active Withdrawn
- 2005-11-14 PL PL10183577T patent/PL2302055T3/pl unknown
- 2005-11-14 ES ES10183490.1T patent/ES2534301T3/es not_active Expired - Lifetime
- 2005-11-14 ES ES10183456.2T patent/ES2503738T3/es not_active Expired - Lifetime
- 2005-11-14 EP EP05858321A patent/EP1838852A2/en not_active Withdrawn
- 2005-11-14 EP EP10183589.0A patent/EP2284265B1/en not_active Expired - Lifetime
- 2005-11-14 EP EP10183456.2A patent/EP2292756B1/en not_active Expired - Lifetime
- 2005-11-14 EP EP10183490.1A patent/EP2302052B1/en not_active Expired - Lifetime
- 2005-11-14 WO PCT/US2005/041162 patent/WO2006137941A2/en not_active Ceased
- 2005-11-14 EP EP10183596.5A patent/EP2302056B1/en not_active Expired - Lifetime
- 2005-11-14 EP EP10183462.0A patent/EP2302051B1/en not_active Expired - Lifetime
- 2005-11-14 EP EP10183639A patent/EP2322616A1/en not_active Withdrawn
- 2005-11-14 EP EP10183525.4A patent/EP2298894B1/en not_active Expired - Lifetime
- 2005-11-14 EP EP10183577.5A patent/EP2302055B1/en not_active Revoked
- 2005-11-14 EP EP10183534.6A patent/EP2302054B1/en not_active Expired - Lifetime
- 2005-11-14 ES ES10183543.7T patent/ES2503743T3/es not_active Expired - Lifetime
- 2005-11-14 ES ES10183567.6T patent/ES2534302T3/es not_active Expired - Lifetime
- 2005-11-14 EP EP14177498.4A patent/EP2808390A1/en not_active Withdrawn
- 2005-11-14 EP EP10183567.6A patent/EP2281888B1/en not_active Expired - Lifetime
- 2005-11-14 ES ES10183534.6T patent/ES2503741T3/es not_active Expired - Lifetime
- 2005-11-14 EP EP10183515A patent/EP2302053A1/en not_active Withdrawn
- 2005-11-14 CA CA2857878A patent/CA2857878A1/en not_active Abandoned
- 2005-11-14 CA CA2857881A patent/CA2857881A1/en not_active Abandoned
- 2005-11-14 EP EP10183451A patent/EP2292755A1/en not_active Withdrawn
- 2005-11-14 ES ES10183525.4T patent/ES2503740T3/es not_active Expired - Lifetime
- 2005-11-14 ES ES10183538.7T patent/ES2503742T3/es not_active Expired - Lifetime
- 2005-11-14 EP EP10183560A patent/EP2281887A1/en not_active Withdrawn
- 2005-11-14 CA CA002587189A patent/CA2587189A1/en not_active Abandoned
- 2005-11-14 ES ES10183577.5T patent/ES2507544T3/es not_active Expired - Lifetime
- 2005-11-14 CA CA2850323A patent/CA2850323A1/en not_active Abandoned
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2007
- 2007-08-10 US US11/837,488 patent/US8058250B2/en not_active Expired - Fee Related
- 2007-08-10 US US11/837,487 patent/US8563708B2/en not_active Expired - Fee Related
- 2007-08-10 US US11/837,490 patent/US7960359B2/en not_active Expired - Fee Related
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2010
- 2010-02-23 JP JP2010036925A patent/JP5389690B2/ja not_active Expired - Fee Related
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2011
- 2011-07-25 US US13/190,232 patent/US20110313025A1/en not_active Abandoned
- 2011-11-17 US US13/299,255 patent/US8946177B2/en not_active Expired - Fee Related
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2012
- 2012-07-05 JP JP2012150997A patent/JP5596085B2/ja not_active Expired - Fee Related
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2013
- 2013-02-07 US US13/761,284 patent/US20130143945A1/en not_active Abandoned
- 2013-05-03 US US13/887,008 patent/US20130303591A1/en not_active Abandoned
- 2013-08-28 US US14/012,302 patent/US8765709B2/en not_active Expired - Fee Related
- 2013-09-05 JP JP2013183871A patent/JP5620556B2/ja not_active Expired - Fee Related
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2014
- 2014-04-16 US US14/254,532 patent/US9051571B2/en not_active Expired - Fee Related
- 2014-05-26 JP JP2014107664A patent/JP2014217381A/ja active Pending
- 2014-07-24 JP JP2014150321A patent/JP2014217384A/ja active Pending
- 2014-07-24 JP JP2014150365A patent/JP2014223080A/ja active Pending
- 2014-07-24 JP JP2014150384A patent/JP2014217386A/ja active Pending
- 2014-07-24 JP JP2014150414A patent/JP2014217387A/ja active Pending
- 2014-07-24 JP JP2014150350A patent/JP2014217385A/ja active Pending
- 2014-08-13 US US14/459,158 patent/US20150005366A1/en not_active Abandoned
- 2014-08-13 US US14/459,119 patent/US20140348907A1/en not_active Abandoned
- 2014-08-13 US US14/459,182 patent/US9382537B2/en not_active Expired - Fee Related
- 2014-08-13 US US14/459,192 patent/US20140348908A1/en not_active Abandoned
- 2014-08-13 US US14/459,074 patent/US9068219B2/en not_active Expired - Fee Related
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2015
- 2015-05-14 US US14/712,591 patent/US9506061B2/en not_active Expired - Fee Related
- 2015-06-03 HK HK15105287.4A patent/HK1204656A1/en unknown
- 2015-06-09 US US14/735,046 patent/US20150275213A1/en not_active Abandoned
- 2015-06-12 US US14/738,646 patent/US20150342981A1/en not_active Abandoned
- 2015-06-12 US US14/738,706 patent/US20150284719A1/en not_active Abandoned
- 2015-06-12 US US14/738,716 patent/US20150284720A1/en not_active Abandoned
- 2015-06-12 US US14/738,734 patent/US20150344883A1/en not_active Abandoned
- 2015-06-12 US US14/738,728 patent/US20150299705A1/en not_active Abandoned
- 2015-06-16 US US14/741,064 patent/US9447414B2/en not_active Expired - Fee Related
- 2015-08-31 US US14/841,377 patent/US20150361431A1/en not_active Abandoned
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2016
- 2016-03-31 JP JP2016069966A patent/JP2016165292A/ja active Pending
- 2016-10-20 US US15/298,781 patent/US20170037404A1/en not_active Abandoned
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