MX348555B - Agente preventivo o terapeutico contra la fibrosis. - Google Patents

Agente preventivo o terapeutico contra la fibrosis.

Info

Publication number
MX348555B
MX348555B MX2013003698A MX2013003698A MX348555B MX 348555 B MX348555 B MX 348555B MX 2013003698 A MX2013003698 A MX 2013003698A MX 2013003698 A MX2013003698 A MX 2013003698A MX 348555 B MX348555 B MX 348555B
Authority
MX
Mexico
Prior art keywords
nucleotide
nucleotides
lying
fibrosis
prophylactic
Prior art date
Application number
MX2013003698A
Other languages
English (en)
Other versions
MX2013003698A (es
Inventor
Hidekazu Toyobuku
Tetsu Kobayashi
Ayako Fukuda
Tetsuya Hasegawa
Esteban C Gabazza
Original Assignee
Otsuka Pharmaceutical Co Ltd *
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Otsuka Pharmaceutical Co Ltd * filed Critical Otsuka Pharmaceutical Co Ltd *
Publication of MX2013003698A publication Critical patent/MX2013003698A/es
Publication of MX348555B publication Critical patent/MX348555B/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C12N15/1135—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against oncogenes or tumor suppressor genes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C12N15/1136—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against growth factors, growth regulators, cytokines, lymphokines or hormones
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A61K31/713—Double-stranded nucleic acids or oligonucleotides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • C07H21/02—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids with ribosyl as saccharide radical
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/10—Type of nucleic acid
    • C12N2310/14—Type of nucleic acid interfering N.A.
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/10—Type of nucleic acid
    • C12N2310/14—Type of nucleic acid interfering N.A.
    • C12N2310/141—MicroRNAs, miRNAs
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/31—Chemical structure of the backbone
    • C12N2310/315—Phosphorothioates
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2320/00—Applications; Uses
    • C12N2320/30—Special therapeutic applications

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biotechnology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biochemistry (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Microbiology (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Plant Pathology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Endocrinology (AREA)
  • Epidemiology (AREA)
  • Pulmonology (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)

Abstract

La presente invención se refiere a siARN eficaz para el tratamiento de la fibrosis y un producto farmacéutico, que contiene siARN; un siARN que tiene una longitud completa de 30 o menos nucleótidos y que se dirige a una secuencia que consiste de 17 a 23 bases consecutivas seleccionadas del grupo que consiste en bases en las posiciones 1285 a 1318, bases en las posiciones 1398 a 1418, bases en las posiciones 1434 a 1463, bases en las posiciones 1548 a 1579, bases en las posiciones 1608 a 1628, bases en las posiciones 1700 a 1726, bases en las posiciones 1778 a 1798, bases en las posiciones 1806 a 1826 y bases en las posiciones 1887 a 1907 de SEQ ID NO: 1.
MX2013003698A 2010-10-14 2011-10-14 Agente preventivo o terapeutico contra la fibrosis. MX348555B (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2010231946 2010-10-14
PCT/JP2011/073628 WO2012050181A1 (ja) 2010-10-14 2011-10-14 線維症予防又は治療剤

Publications (2)

Publication Number Publication Date
MX2013003698A MX2013003698A (es) 2013-05-20
MX348555B true MX348555B (es) 2017-06-16

Family

ID=45938402

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2013003698A MX348555B (es) 2010-10-14 2011-10-14 Agente preventivo o terapeutico contra la fibrosis.

Country Status (30)

Country Link
US (6) US8772262B2 (es)
EP (2) EP3517614A1 (es)
JP (4) JP6022940B2 (es)
KR (2) KR102167225B1 (es)
CN (2) CN103119166B (es)
AR (1) AR083445A1 (es)
AU (1) AU2011314653B2 (es)
BR (1) BR112013006541A2 (es)
CA (1) CA2813163C (es)
CO (1) CO6660456A2 (es)
CY (1) CY1121945T1 (es)
DK (1) DK2628798T3 (es)
ES (1) ES2720135T3 (es)
HK (1) HK1184189A1 (es)
HR (1) HRP20190722T1 (es)
HU (1) HUE043891T2 (es)
IL (2) IL224791A (es)
LT (1) LT2628798T (es)
MX (1) MX348555B (es)
MY (1) MY165964A (es)
NZ (2) NZ630501A (es)
PL (1) PL2628798T3 (es)
PT (1) PT2628798T (es)
RU (1) RU2583290C2 (es)
SG (3) SG10201907649QA (es)
SI (1) SI2628798T1 (es)
TR (1) TR201905060T4 (es)
TW (2) TWI679023B (es)
WO (1) WO2012050181A1 (es)
ZA (1) ZA201301279B (es)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AR083445A1 (es) * 2010-10-14 2013-02-27 Univ Mie siARN CONTRA LA FIBROSIS
WO2015093495A1 (ja) * 2013-12-16 2015-06-25 株式会社ボナック ＴＧＦ－β１遺伝子発現制御のための一本鎖核酸分子
JP6726105B2 (ja) 2014-12-15 2020-07-22 株式会社ボナック ＴＧＦ−β１発現抑制のための一本鎖核酸分子
WO2017043490A1 (ja) * 2015-09-07 2017-03-16 協和発酵バイオ株式会社 自然免疫誘導効果が増強した二重鎖リボ核酸
WO2017073767A1 (ja) * 2015-10-30 2017-05-04 株式会社ボナック ＴＧＦ－β１遺伝子の発現を抑制する一本鎖核酸分子を安定に含有する組成物

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Also Published As

Publication number Publication date
HK1184189A1 (zh) 2014-01-17
US20200291406A1 (en) 2020-09-17
PT2628798T (pt) 2019-05-14
AU2011314653A1 (en) 2013-03-28
TW201627012A (zh) 2016-08-01
KR101853799B1 (ko) 2018-05-02
US20130217754A1 (en) 2013-08-22
US20160130586A1 (en) 2016-05-12
JP2018088923A (ja) 2018-06-14
RU2013121802A (ru) 2014-11-20
ZA201301279B (en) 2014-04-30
SG10201508365RA (en) 2015-11-27
EP2628798A1 (en) 2013-08-21
CA2813163C (en) 2020-11-03
WO2012050181A1 (ja) 2012-04-19
CY1121945T1 (el) 2020-10-14
TR201905060T4 (tr) 2019-05-21
TWI572715B (zh) 2017-03-01
JP2017000155A (ja) 2017-01-05
DK2628798T3 (da) 2019-05-06
IL245995A0 (en) 2016-07-31
CO6660456A2 (es) 2013-04-30
TWI679023B (zh) 2019-12-11
IL224791A (en) 2017-09-28
MY165964A (en) 2018-05-18
SI2628798T1 (sl) 2019-06-28
JP6022940B2 (ja) 2016-11-09
CN103119166A (zh) 2013-05-22
HUE043891T2 (hu) 2019-09-30
AR083445A1 (es) 2013-02-27
IL245995B (en) 2018-05-31
US8772262B2 (en) 2014-07-08
PL2628798T3 (pl) 2019-09-30
ES2720135T3 (es) 2019-07-18
KR102167225B1 (ko) 2020-10-20
CN106086022A (zh) 2016-11-09
LT2628798T (lt) 2019-05-10
EP2628798A4 (en) 2014-02-26
US20170198293A1 (en) 2017-07-13
JPWO2012050181A1 (ja) 2014-02-24
CN103119166B (zh) 2016-06-22
EP3517614A1 (en) 2019-07-31
SG189245A1 (en) 2013-05-31
BR112013006541A2 (pt) 2017-09-19
KR20180049152A (ko) 2018-05-10
RU2583290C2 (ru) 2016-05-10
NZ630501A (en) 2015-11-27
SG10201907649QA (en) 2019-09-27
AU2011314653B2 (en) 2015-09-03
KR20140020820A (ko) 2014-02-19
US10125366B2 (en) 2018-11-13
CN106086022B (zh) 2020-10-09
NZ609440A (en) 2014-10-31
TW201216988A (en) 2012-05-01
JP2020078314A (ja) 2020-05-28
EP2628798B1 (en) 2019-03-27
MX2013003698A (es) 2013-05-20
US9273314B2 (en) 2016-03-01
US20140288151A1 (en) 2014-09-25
US20190010500A1 (en) 2019-01-10
HRP20190722T1 (hr) 2019-06-14
CA2813163A1 (en) 2012-04-19
US9637743B2 (en) 2017-05-02

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