SG10201508365RA - Preventive or therapeutic agent for fibrosis - Google Patents

Preventive or therapeutic agent for fibrosis

Info

Publication number
SG10201508365RA
SG10201508365RA SG10201508365RA SG10201508365RA SG10201508365RA SG 10201508365R A SG10201508365R A SG 10201508365RA SG 10201508365R A SG10201508365R A SG 10201508365RA SG 10201508365R A SG10201508365R A SG 10201508365RA SG 10201508365R A SG10201508365R A SG 10201508365RA
Authority
SG
Singapore
Prior art keywords
fibrosis
preventive
therapeutic agent
therapeutic
agent
Prior art date
Application number
SG10201508365RA
Inventor
Gabazza Esteban
Tetsu Kobayashi
Hidekazu Toyobuku
Ayako Fukuda
Tetsuya Hasegawa
Original Assignee
Univ Mie
Otsuka Pharma Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Mie, Otsuka Pharma Co Ltd filed Critical Univ Mie
Publication of SG10201508365RA publication Critical patent/SG10201508365RA/en

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    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/11DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C12N15/1135Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against oncogenes or tumor suppressor genes
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/11DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C12N15/1136Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against growth factors, growth regulators, cytokines, lymphokines or hormones
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/70Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088Compounds having three or more nucleosides or nucleotides
    • A61K31/713Double-stranded nucleic acids or oligonucleotides
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07HSUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • C07H21/02Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids with ribosyl as saccharide radical
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/11DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00Structure or type of the nucleic acid
    • C12N2310/10Type of nucleic acid
    • C12N2310/14Type of nucleic acid interfering N.A.
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00Structure or type of the nucleic acid
    • C12N2310/10Type of nucleic acid
    • C12N2310/14Type of nucleic acid interfering N.A.
    • C12N2310/141MicroRNAs, miRNAs
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00Structure or type of the nucleic acid
    • C12N2310/30Chemical structure
    • C12N2310/31Chemical structure of the backbone
    • C12N2310/315Phosphorothioates
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2320/00Applications; Uses
    • C12N2320/30Special therapeutic applications

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biotechnology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biochemistry (AREA)
  • Wood Science & Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Microbiology (AREA)
  • Plant Pathology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Endocrinology (AREA)
  • Epidemiology (AREA)
  • Pulmonology (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
SG10201508365RA 2010-10-14 2011-10-14 Preventive or therapeutic agent for fibrosis SG10201508365RA (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP2010231946 2010-10-14

Publications (1)

Publication Number Publication Date
SG10201508365RA true SG10201508365RA (en) 2015-11-27

Family

ID=45938402

Family Applications (3)

Application Number Title Priority Date Filing Date
SG2013024757A SG189245A1 (en) 2010-10-14 2011-10-14 Preventive or therapeutic agent for fibrosis
SG10201508365RA SG10201508365RA (en) 2010-10-14 2011-10-14 Preventive or therapeutic agent for fibrosis
SG10201907649QA SG10201907649QA (en) 2010-10-14 2011-10-14 Preventive or therapeutic agent for fibrosis

Family Applications Before (1)

Application Number Title Priority Date Filing Date
SG2013024757A SG189245A1 (en) 2010-10-14 2011-10-14 Preventive or therapeutic agent for fibrosis

Family Applications After (1)

Application Number Title Priority Date Filing Date
SG10201907649QA SG10201907649QA (en) 2010-10-14 2011-10-14 Preventive or therapeutic agent for fibrosis

Country Status (30)

Country Link
US (6) US8772262B2 (en)
EP (2) EP3517614A1 (en)
JP (4) JP6022940B2 (en)
KR (2) KR101853799B1 (en)
CN (2) CN106086022B (en)
AR (1) AR083445A1 (en)
AU (1) AU2011314653B2 (en)
BR (1) BR112013006541A2 (en)
CA (1) CA2813163C (en)
CO (1) CO6660456A2 (en)
CY (1) CY1121945T1 (en)
DK (1) DK2628798T3 (en)
ES (1) ES2720135T3 (en)
HK (1) HK1184189A1 (en)
HR (1) HRP20190722T1 (en)
HU (1) HUE043891T2 (en)
IL (2) IL224791A (en)
LT (1) LT2628798T (en)
MX (1) MX348555B (en)
MY (1) MY165964A (en)
NZ (2) NZ630501A (en)
PL (1) PL2628798T3 (en)
PT (1) PT2628798T (en)
RU (1) RU2583290C2 (en)
SG (3) SG189245A1 (en)
SI (1) SI2628798T1 (en)
TR (1) TR201905060T4 (en)
TW (2) TWI679023B (en)
WO (1) WO2012050181A1 (en)
ZA (1) ZA201301279B (en)

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WO2017043490A1 (en) * 2015-09-07 2017-03-16 協和発酵バイオ株式会社 Double-stranded ribonucleic acid having enhanced natural immunity inducing effect
AU2016346703B2 (en) * 2015-10-30 2020-07-02 Hirofumi Takeuchi Composition stably containing single-stranded nucleic acid molecule that suppresses expression of TGF-β1 gene

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Also Published As

Publication number Publication date
EP3517614A1 (en) 2019-07-31
RU2583290C2 (en) 2016-05-10
US20190010500A1 (en) 2019-01-10
EP2628798B1 (en) 2019-03-27
DK2628798T3 (en) 2019-05-06
ES2720135T3 (en) 2019-07-18
KR20140020820A (en) 2014-02-19
HK1184189A1 (en) 2014-01-17
US10125366B2 (en) 2018-11-13
TWI572715B (en) 2017-03-01
JP2017000155A (en) 2017-01-05
SG189245A1 (en) 2013-05-31
EP2628798A4 (en) 2014-02-26
MX2013003698A (en) 2013-05-20
TR201905060T4 (en) 2019-05-21
KR102167225B1 (en) 2020-10-20
US9273314B2 (en) 2016-03-01
US20170198293A1 (en) 2017-07-13
US20130217754A1 (en) 2013-08-22
HRP20190722T1 (en) 2019-06-14
US9637743B2 (en) 2017-05-02
CN103119166A (en) 2013-05-22
AU2011314653A1 (en) 2013-03-28
BR112013006541A2 (en) 2017-09-19
US20140288151A1 (en) 2014-09-25
LT2628798T (en) 2019-05-10
JPWO2012050181A1 (en) 2014-02-24
CA2813163A1 (en) 2012-04-19
PL2628798T3 (en) 2019-09-30
MY165964A (en) 2018-05-18
KR20180049152A (en) 2018-05-10
JP2018088923A (en) 2018-06-14
NZ630501A (en) 2015-11-27
JP2020078314A (en) 2020-05-28
CN103119166B (en) 2016-06-22
IL245995B (en) 2018-05-31
TWI679023B (en) 2019-12-11
WO2012050181A1 (en) 2012-04-19
IL245995A0 (en) 2016-07-31
US20160130586A1 (en) 2016-05-12
AR083445A1 (en) 2013-02-27
CO6660456A2 (en) 2013-04-30
HUE043891T2 (en) 2019-09-30
PT2628798T (en) 2019-05-14
RU2013121802A (en) 2014-11-20
TW201216988A (en) 2012-05-01
CN106086022A (en) 2016-11-09
EP2628798A1 (en) 2013-08-21
US8772262B2 (en) 2014-07-08
KR101853799B1 (en) 2018-05-02
AU2011314653B2 (en) 2015-09-03
CN106086022B (en) 2020-10-09
TW201627012A (en) 2016-08-01
CY1121945T1 (en) 2020-10-14
MX348555B (en) 2017-06-16
ZA201301279B (en) 2014-04-30
IL224791A (en) 2017-09-28
JP6022940B2 (en) 2016-11-09
NZ609440A (en) 2014-10-31
CA2813163C (en) 2020-11-03
US20200291406A1 (en) 2020-09-17
SG10201907649QA (en) 2019-09-27
SI2628798T1 (en) 2019-06-28

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