ES2534304T3 - Procedimientos y composiciones que implican miARN y moléculas inhibidoras de miARN - Google Patents
Procedimientos y composiciones que implican miARN y moléculas inhibidoras de miARN Download PDFInfo
- Publication number
- ES2534304T3 ES2534304T3 ES10183596.5T ES10183596T ES2534304T3 ES 2534304 T3 ES2534304 T3 ES 2534304T3 ES 10183596 T ES10183596 T ES 10183596T ES 2534304 T3 ES2534304 T3 ES 2534304T3
- Authority
- ES
- Spain
- Prior art keywords
- mirna
- procedures
- inhibitor molecules
- compositions involving
- sequence
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7088—Compounds having three or more nucleosides or nucleotides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7088—Compounds having three or more nucleosides or nucleotides
- A61K31/7105—Natural ribonucleic acids, i.e. containing only riboses attached to adenine, guanine, cytosine or uracil and having 3'-5' phosphodiester links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7088—Compounds having three or more nucleosides or nucleotides
- A61K31/713—Double-stranded nucleic acids or oligonucleotides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/127—Liposomes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N5/00—Radiation therapy
- A61N5/10—X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
- A61P31/06—Antibacterial agents for tuberculosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/111—General methods applicable to biologically active non-coding nucleic acids
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
- C12N15/1136—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against growth factors, growth regulators, cytokines, lymphokines or hormones
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/10—Type of nucleic acid
- C12N2310/14—Type of nucleic acid interfering N.A.
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/10—Type of nucleic acid
- C12N2310/14—Type of nucleic acid interfering N.A.
- C12N2310/141—MicroRNAs, miRNAs
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/30—Chemical structure
- C12N2310/31—Chemical structure of the backbone
- C12N2310/312—Phosphonates
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/30—Chemical structure
- C12N2310/32—Chemical structure of the sugar
- C12N2310/321—2'-O-R Modification
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/30—Chemical structure
- C12N2310/32—Chemical structure of the sugar
- C12N2310/322—2'-R Modification
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/30—Chemical structure
- C12N2310/33—Chemical structure of the base
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/30—Chemical structure
- C12N2310/34—Spatial arrangement of the modifications
- C12N2310/344—Position-specific modifications, e.g. on every purine, at the 3'-end
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/30—Chemical structure
- C12N2310/35—Nature of the modification
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/30—Chemical structure
- C12N2310/35—Nature of the modification
- C12N2310/351—Conjugate
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/30—Chemical structure
- C12N2310/35—Nature of the modification
- C12N2310/352—Nature of the modification linked to the nucleic acid via a carbon atom
- C12N2310/3527—Other alkyl chain
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/30—Chemical structure
- C12N2310/35—Nature of the modification
- C12N2310/353—Nature of the modification linked to the nucleic acid via an atom other than carbon
- C12N2310/3535—Nitrogen
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/50—Physical structure
- C12N2310/53—Physical structure partially self-complementary or closed
- C12N2310/533—Physical structure partially self-complementary or closed having a mismatch or nick in at least one of the strands
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2320/00—Applications; Uses
- C12N2320/10—Applications; Uses in screening processes
- C12N2320/12—Applications; Uses in screening processes in functional genomics, i.e. for the determination of gene function
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2320/00—Applications; Uses
- C12N2320/30—Special therapeutic applications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2320/00—Applications; Uses
- C12N2320/50—Methods for regulating/modulating their activity
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2330/00—Production
- C12N2330/10—Production naturally occurring
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/158—Expression markers
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/178—Oligonucleotides characterized by their use miRNA, siRNA or ncRNA
Abstract
Una molécula de ácido nucleico de miARN sintético que comprende una secuencia con al menos 80 % de identidad de secuencia con la secuencia de miR-29 humana madura para su uso como un medicamento.
Applications Claiming Priority (6)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US62717104P | 2004-11-12 | 2004-11-12 | |
US627171P | 2004-11-12 | ||
US64963405P | 2005-02-03 | 2005-02-03 | |
US649634P | 2005-02-03 | ||
US68373605P | 2005-05-23 | 2005-05-23 | |
US683736P | 2005-05-23 |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2534304T3 true ES2534304T3 (es) | 2015-04-21 |
Family
ID=37570916
Family Applications (13)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES10183611.2T Active ES2503765T3 (es) | 2004-11-12 | 2005-11-14 | Procedimientos y composiciones que implican miARN y moléculas inhibidoras de miARN |
ES10183490.1T Active ES2534301T3 (es) | 2004-11-12 | 2005-11-14 | Procedimientos y composiciones que implican miARN y moléculas inhibidoras de miARN |
ES10183567.6T Active ES2534302T3 (es) | 2004-11-12 | 2005-11-14 | Procedimientos y composiciones que implican miARN y moléculas inhibidoras de miARN |
ES10183589.0T Active ES2534303T3 (es) | 2004-11-12 | 2005-11-14 | Procedimientos y composiciones que implican miARN y moléculas inhibidoras de miARN |
ES10183462.0T Active ES2534300T3 (es) | 2004-11-12 | 2005-11-14 | Procedimientos y composiciones que implican miARN y moléculas inhibidoras de miARN |
ES10183456.2T Active ES2503738T3 (es) | 2004-11-12 | 2005-11-14 | Procedimientos y composiciones que implican miARN y moléculas inhibidoras de miARN |
ES10183577.5T Active ES2507544T3 (es) | 2004-11-12 | 2005-11-14 | Procedimientos y composiciones que implican miARN y moléculas inhibidoras de miARN |
ES10183596.5T Active ES2534304T3 (es) | 2004-11-12 | 2005-11-14 | Procedimientos y composiciones que implican miARN y moléculas inhibidoras de miARN |
ES10183481.0T Active ES2503739T3 (es) | 2004-11-12 | 2005-11-14 | Procedimientos y composiciones que implican miARN y moléculas inhibidoras de miARN |
ES10183525.4T Active ES2503740T3 (es) | 2004-11-12 | 2005-11-14 | Procedimientos y composiciones que implican miARN y moléculas inhibidoras de miARN |
ES10183534.6T Active ES2503741T3 (es) | 2004-11-12 | 2005-11-14 | Procedimientos y composiciones que implican miARN y moléculas inhibidoras de miARN |
ES10183543.7T Active ES2503743T3 (es) | 2004-11-12 | 2005-11-14 | Procedimientos y composiciones que implican miARN y moléculas inhibidoras de miARN |
ES10183538.7T Active ES2503742T3 (es) | 2004-11-12 | 2005-11-14 | Procedimientos y composiciones que implican miARN y moléculas inhibidoras de miARN |
Family Applications Before (7)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES10183611.2T Active ES2503765T3 (es) | 2004-11-12 | 2005-11-14 | Procedimientos y composiciones que implican miARN y moléculas inhibidoras de miARN |
ES10183490.1T Active ES2534301T3 (es) | 2004-11-12 | 2005-11-14 | Procedimientos y composiciones que implican miARN y moléculas inhibidoras de miARN |
ES10183567.6T Active ES2534302T3 (es) | 2004-11-12 | 2005-11-14 | Procedimientos y composiciones que implican miARN y moléculas inhibidoras de miARN |
ES10183589.0T Active ES2534303T3 (es) | 2004-11-12 | 2005-11-14 | Procedimientos y composiciones que implican miARN y moléculas inhibidoras de miARN |
ES10183462.0T Active ES2534300T3 (es) | 2004-11-12 | 2005-11-14 | Procedimientos y composiciones que implican miARN y moléculas inhibidoras de miARN |
ES10183456.2T Active ES2503738T3 (es) | 2004-11-12 | 2005-11-14 | Procedimientos y composiciones que implican miARN y moléculas inhibidoras de miARN |
ES10183577.5T Active ES2507544T3 (es) | 2004-11-12 | 2005-11-14 | Procedimientos y composiciones que implican miARN y moléculas inhibidoras de miARN |
Family Applications After (5)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES10183481.0T Active ES2503739T3 (es) | 2004-11-12 | 2005-11-14 | Procedimientos y composiciones que implican miARN y moléculas inhibidoras de miARN |
ES10183525.4T Active ES2503740T3 (es) | 2004-11-12 | 2005-11-14 | Procedimientos y composiciones que implican miARN y moléculas inhibidoras de miARN |
ES10183534.6T Active ES2503741T3 (es) | 2004-11-12 | 2005-11-14 | Procedimientos y composiciones que implican miARN y moléculas inhibidoras de miARN |
ES10183543.7T Active ES2503743T3 (es) | 2004-11-12 | 2005-11-14 | Procedimientos y composiciones que implican miARN y moléculas inhibidoras de miARN |
ES10183538.7T Active ES2503742T3 (es) | 2004-11-12 | 2005-11-14 | Procedimientos y composiciones que implican miARN y moléculas inhibidoras de miARN |
Country Status (11)
Country | Link |
---|---|
US (25) | US8173611B2 (es) |
EP (21) | EP2281888B1 (es) |
JP (11) | JP2008519606A (es) |
AU (1) | AU2005333165B2 (es) |
CA (7) | CA2857879A1 (es) |
DK (1) | DK2302055T3 (es) |
ES (13) | ES2503765T3 (es) |
HK (1) | HK1204656A1 (es) |
PL (1) | PL2302055T3 (es) |
SI (1) | SI2302055T1 (es) |
WO (1) | WO2006137941A2 (es) |
Families Citing this family (373)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AU2002347035B2 (en) | 2001-09-28 | 2008-04-03 | Max-Planck-Gesellschaft Zur Forderung Der Wissenschaften E.V | Micro-RNA molecules |
EP2290068A3 (en) | 2004-05-28 | 2012-01-04 | Asuragen, Inc. | Methods and compositions involving microRNA |
EP1791954A1 (en) * | 2004-09-07 | 2007-06-06 | Yissum Research Development Company Of The Hebrew University Of Jerusalem | Agents, compositions and methods for treating pathologies in which regulating an ache-associated biological pathway is beneficial |
US20090186353A1 (en) * | 2004-10-04 | 2009-07-23 | Rosetta Genomics Ltd. | Cancer-related nucleic acids |
US7642348B2 (en) * | 2004-10-04 | 2010-01-05 | Rosetta Genomics Ltd | Prostate cancer-related nucleic acids |
US7825229B2 (en) * | 2005-03-25 | 2010-11-02 | Rosetta Genomics Ltd. | Lung cancer-related nucleic acids |
ES2503765T3 (es) * | 2004-11-12 | 2014-10-07 | Asuragen, Inc. | Procedimientos y composiciones que implican miARN y moléculas inhibidoras de miARN |
US8592384B2 (en) | 2005-04-04 | 2013-11-26 | The Board Of Regents Of The University Of Texas System | Micro-RNA's that regulate muscle cells |
WO2006119266A2 (en) * | 2005-04-29 | 2006-11-09 | Rockefeller University | Human micrornas and methods for inhibiting same |
US20090209621A1 (en) * | 2005-06-03 | 2009-08-20 | The Johns Hopkins University | Compositions and methods for decreasing microrna expression for the treatment of neoplasia |
CN105902559A (zh) * | 2005-08-01 | 2016-08-31 | 俄亥俄州立大学研究基金会 | 用于乳腺癌的诊断、预后和治疗的基于MicroRNA的方法和组合物 |
CN101296702B (zh) | 2005-09-12 | 2012-11-28 | 俄亥俄州立大学研究基金会 | 用于诊断或治疗bcl2相关癌症的组合物和方法 |
EP1940456A4 (en) * | 2005-10-05 | 2009-10-21 | Univ Ohio State Res Found | WWOX GENE, VECTORS COMPRISING THE SAME, AND USES THEREOF IN THE TREATMENT OF CANCER |
CA2634046A1 (en) | 2005-12-12 | 2007-06-21 | The University Of North Carolina At Chapel Hill | Micrornas that regulate muscle cell proliferation and differentiation |
ES2545118T3 (es) * | 2006-01-05 | 2015-09-08 | The Ohio State University Research Foundation | Métodos basados en microARN y composiciones para el diagnóstico y tratamiento de cánceres sólidos |
AU2007205234B2 (en) * | 2006-01-05 | 2012-07-12 | The Ohio State University Research Foundation | MicroRNA-based methods and compositions for the diagnosis, prognosis and treatment of lung cancer |
AU2016203848B2 (en) * | 2006-01-05 | 2017-12-14 | The Ohio State University Research Foundation | MicroRNA-based methods and compositions for the diagnosis, prognosis and treatment of lung cancer |
US7670840B2 (en) | 2006-01-05 | 2010-03-02 | The Ohio State University Research Foundation | Micro-RNA expression abnormalities of pancreatic, endocrine and acinar tumors |
WO2007109236A2 (en) * | 2006-03-20 | 2007-09-27 | The Ohio State University Research Foundation | Microrna fingerprints during human megakaryocytopoiesis |
ES2569558T3 (es) | 2006-04-03 | 2016-05-11 | Roche Innovation Center Copenhagen A/S | Composición farmacéutica que comprende oligonucleótidos antisentido anti-ARNmi |
WO2007112753A2 (en) | 2006-04-03 | 2007-10-11 | Santaris Pharma A/S | Pharmaceutical composition comprising anti-mirna antisense oligonucleotides |
ES2434075T3 (es) | 2006-07-13 | 2013-12-13 | The Ohio State University Research Foundation | MIR-203 para el diagnóstico de adenocarcinoma de colon con mal pronóstico de supervivencia |
CA2659364C (en) | 2006-08-01 | 2017-08-22 | Board Of Regents Of The University Of Texas System | Identification of a micro-rna that activates expression of .beta.-myosin heavy chain |
JP2009545309A (ja) † | 2006-08-04 | 2009-12-24 | ダブリン シティ ユニバーシティ | 組換え型生物学的製剤を製造する方法 |
US8673872B2 (en) * | 2006-08-28 | 2014-03-18 | The University Of Western Australia | Method of modulation of expression of epidermal growth factor receptor(EGFR) involving miRNA |
EP2374884A3 (en) * | 2006-09-04 | 2012-01-11 | Kyowa Hakko Kirin Co., Ltd. | Human miRNAs isolated from mesenchymal stem cells |
ES2374446T3 (es) | 2006-09-19 | 2012-02-16 | The Ohio State University Research Foundation | Expresión de tcl1 en la leucemia linfocítica crónica (llc) regulada por mir-29 y mir-181. |
EP2145001A2 (en) * | 2006-09-19 | 2010-01-20 | Asuragen, Inc. | Mir-15, mir-26, mir -31,mir -145, mir-147, mir-188, mir-215, mir-216 mir-331, mmu-mir-292-3p regulated genes and pathways as targets for therapeutic intervention |
US7803784B2 (en) * | 2006-10-24 | 2010-09-28 | The Board Of Trustees Of The Leland Stanford Junior University | Modulation of T cell signaling threshold and T cell sensitivity to antigens |
EP2087135B8 (en) | 2006-11-01 | 2013-07-24 | The Ohio State University Research Foundation | Microrna expression signature for predicting survival and metastases in hepatocellular carcinoma |
US20080131878A1 (en) * | 2006-12-05 | 2008-06-05 | Asuragen, Inc. | Compositions and Methods for the Detection of Small RNA |
US20090092974A1 (en) * | 2006-12-08 | 2009-04-09 | Asuragen, Inc. | Micrornas differentially expressed in leukemia and uses thereof |
AU2007333106A1 (en) * | 2006-12-08 | 2008-06-19 | Asuragen, Inc. | miR-20 regulated genes and pathways as targets for therapeutic intervention |
ATE534738T1 (de) * | 2006-12-08 | 2011-12-15 | Asuragen Inc | Mir-126-regulierte gene und pfade als ziele für therapeutische interventionen |
CA2671294A1 (en) * | 2006-12-08 | 2008-06-19 | Asuragen, Inc. | Mir-21 regulated genes and pathways as targets for therapeutic intervention |
EP2104737B1 (en) * | 2006-12-08 | 2013-04-10 | Asuragen, INC. | Functions and targets of let-7 micro rnas |
US20090175827A1 (en) * | 2006-12-29 | 2009-07-09 | Byrom Mike W | miR-16 REGULATED GENES AND PATHWAYS AS TARGETS FOR THERAPEUTIC INTERVENTION |
EP2111408A4 (en) * | 2007-01-17 | 2010-02-03 | Univ Johns Hopkins | COMPOSITIONS AND METHODS COMPRISING MICROARNS FOR TREATING NEOPLASIA |
CN101627134B (zh) | 2007-01-31 | 2013-11-06 | 俄亥俄州立大学研究基金会 | 用于急性髓细胞白血病(aml)的诊断、预后和治疗的基于微rna的方法和组合物 |
AU2008220438A1 (en) * | 2007-02-27 | 2008-09-04 | Rosetta Genomics Ltd. | Composition and methods for modulating cell proliferation and cell death |
US9006206B2 (en) | 2007-02-27 | 2015-04-14 | Rosetta Genomics Ltd. | Composition and methods for modulating cell proliferation and cell death |
EP2134842A2 (en) * | 2007-03-07 | 2009-12-23 | Yissum Research Development Company of the Hebrew University of Jerusalem Ltd | Agents, compositions and methods for treating pathologies in which regulating an ache-associated biological pathway is beneficial |
WO2008115387A2 (en) * | 2007-03-15 | 2008-09-25 | University Hospitals Of Cleveland | Screening, diagnosing, treating and prognosis of pathophysiologic states by rna regulation |
EP2136846A4 (en) * | 2007-03-26 | 2011-04-13 | Crc For Asthma And Airways Ltd | THERAPEUTIC OBJECTIVES AND MOLECULES |
US20100273172A1 (en) * | 2007-03-27 | 2010-10-28 | Rosetta Genomics Ltd. | Micrornas expression signature for determination of tumors origin |
US20090117562A1 (en) | 2007-04-09 | 2009-05-07 | Valerie Wailin Hu | Method and kit for diagnosing Autism using gene expression profiling |
CN101827941B (zh) * | 2007-04-30 | 2014-07-16 | 俄亥俄州立大学研究基金会 | 用于区分胰腺癌与正常胰腺功能和/或慢性胰腺炎的方法 |
EP1990414A1 (en) * | 2007-05-10 | 2008-11-12 | Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. | Means for treating inflammatory diseases, autoimmune diseases and cancer |
US20090232893A1 (en) * | 2007-05-22 | 2009-09-17 | Bader Andreas G | miR-143 REGULATED GENES AND PATHWAYS AS TARGETS FOR THERAPEUTIC INTERVENTION |
WO2008147974A1 (en) * | 2007-05-23 | 2008-12-04 | University Of South Florida | Micro-rnas modulating immunity and inflammation |
AU2008261951A1 (en) * | 2007-06-08 | 2008-12-18 | Asuragen, Inc. | miR-34 regulated genes and pathways as targets for therapeutic intervention |
JP5690588B2 (ja) | 2007-06-08 | 2015-03-25 | アメリカ合衆国 | 肝細胞癌のサブタイプを決定し、肝癌幹細胞を検出するための方法 |
US8053186B2 (en) | 2007-06-15 | 2011-11-08 | The Ohio State University Research Foundation | Oncogenic ALL-1 fusion proteins for targeting Drosha-mediated microRNA processing |
US20090012031A1 (en) * | 2007-07-03 | 2009-01-08 | The Regents Of The University Of Michigan | EZH2 Cancer Markers |
AU2008282318B2 (en) | 2007-07-31 | 2014-02-27 | The Ohio State University Research Foundation | Methods for reverting methylation by targeting methyltransferases |
NZ583025A (en) | 2007-07-31 | 2012-06-29 | Univ Texas | Micro-rnas that control myosin expression and myofiber identity |
EP2182969B1 (en) | 2007-07-31 | 2016-11-16 | The Board of Regents of The University of Texas System | A micro-rna family that modulates fibrosis and uses thereof |
EP2185700A4 (en) * | 2007-08-02 | 2010-11-24 | Texas A & M Univ Sys | ANTISENSE MICRO RNA AND USES THEREOF |
EP2650383A1 (en) * | 2007-08-03 | 2013-10-16 | The Ohio State University Research Foundation | Ultraconserved regions encoding ncRNAs |
WO2009021235A2 (en) * | 2007-08-09 | 2009-02-12 | The Regents Of The University Of Colorado | Methods and compositions for treating cancer |
CA2733676A1 (en) | 2007-08-10 | 2009-02-19 | British Columbia Cancer Agency Branch | Microrna compositions and methods for the treatment of myelogenous leukemia |
EP3028708A1 (en) | 2007-08-22 | 2016-06-08 | The Ohio State University Research Foundation | Methods and compositions for inducing deregulation of epha7 and erk phosphorylation in human acute leukemias |
CN101376910B (zh) * | 2007-08-27 | 2012-01-11 | 中国科学院上海生命科学研究院 | 微小rna基因在系统性红斑狼疮疾病诊断和治疗中的作用 |
JP5401460B2 (ja) * | 2007-09-06 | 2014-01-29 | ジ・オハイオ・ステイト・ユニバーシティ・リサーチ・ファウンデイション | ヒト卵巣癌中のマイクロrnaシグネチャー |
US8361714B2 (en) | 2007-09-14 | 2013-01-29 | Asuragen, Inc. | Micrornas differentially expressed in cervical cancer and uses thereof |
WO2009044895A1 (ja) * | 2007-10-03 | 2009-04-09 | Kyowa Hakko Kirin Co., Ltd. | 標的遺伝子の発現を抑制する組成物 |
EP2208499A4 (en) * | 2007-10-03 | 2011-12-28 | Kyowa Hakko Kirin Co Ltd | NUCLEIC ACID FOR REGULATING CELL PROLIFERATION |
EA019939B1 (ru) | 2007-10-04 | 2014-07-30 | Сантарис Фарма А/С | МОДИФИЦИРОВАННЫЙ ОЛИГОМЕР ДЛЯ УМЕНЬШЕНИЯ КОЛИЧЕСТВА микроРНК В КЛЕТКЕ |
WO2009049129A1 (en) * | 2007-10-11 | 2009-04-16 | The Ohio State University Research Foundation | Methods and compositions for the diagnosis and treatment of esphageal adenocarcinomas |
WO2009052386A1 (en) * | 2007-10-18 | 2009-04-23 | Asuragen, Inc. | Micrornas differentially expressed in lung diseases and uses thereof |
CN103898069A (zh) | 2007-10-26 | 2014-07-02 | 俄亥俄州立大学研究基金会 | 鉴定脆性组氨酸三联体(Fhit)相互作用的方法及其用途 |
WO2009058907A2 (en) | 2007-10-29 | 2009-05-07 | Isis Pharmaceuticals, Inc. | Targeting micrornas for the treatment of liver cancer |
US8034573B2 (en) * | 2007-11-05 | 2011-10-11 | Kci Licensing Inc. | Identification of tissue for debridement |
MX2010005166A (es) * | 2007-11-09 | 2010-10-07 | Univ Texas | Micro arn de la familia mir-15 que modulan la sobrevivencia de cardiomiocitos y reparacion cardiaca. |
ITRM20070595A1 (it) * | 2007-11-15 | 2009-05-16 | Univ Roma | Mirna e sirna e loro uso in terapia |
WO2009066967A2 (en) * | 2007-11-23 | 2009-05-28 | Panagene Inc. | Microrna antisense pnas, compositions comprising the same, and methods for using and evaluating the same |
EP2225396A4 (en) * | 2007-11-30 | 2011-03-02 | Univ Ohio State Res Found | PROFILING AND SCREENING OF MICRO-RNA EXPRESSION IN PERIPHERAL BLOOD IN LUNG CANCER |
WO2009070805A2 (en) * | 2007-12-01 | 2009-06-04 | Asuragen, Inc. | Mir-124 regulated genes and pathways as targets for therapeutic intervention |
WO2009086156A2 (en) * | 2007-12-21 | 2009-07-09 | Asuragen, Inc. | Mir-10 regulated genes and pathways as targets for therapeutic intervention |
KR101325186B1 (ko) | 2008-01-23 | 2013-11-07 | (주)바이오니아 | 이중가닥 miRNA를 유효성분으로 포함하는 항암제 |
JP5116026B2 (ja) | 2008-01-23 | 2013-01-09 | 富士フイルム株式会社 | 癌の検出方法および癌抑制剤 |
EP2234483A4 (en) * | 2008-01-27 | 2011-04-27 | Rosetta Genomics Ltd | METHOD AND COMPOSITIONS FOR DIAGNOSIS OF PREGNANCY COMPLICATIONS |
EP2260110B1 (en) * | 2008-02-08 | 2014-11-12 | Asuragen, INC. | miRNAs DIFFERENTIALLY EXPRESSED IN LYMPH NODES FROM CANCER PATIENTS |
JP5662166B2 (ja) * | 2008-02-28 | 2015-01-28 | ジ・オハイオ・ステイト・ユニバーシティ・リサーチ・ファウンデイションThe Ohio State University Research Foundation | 胃癌の診断、予後診断及び治療のためのマイクロrnaに基づいた方法及び組成物 |
EP2254668A4 (en) * | 2008-02-28 | 2012-08-15 | Univ Ohio State Res Found | MICRORNA SIGNATURES ASSOCIATED WITH HUMAN CHRONIC LYMPHOCYTIC LEUKEMIA (CLL) AND THEIR USE |
WO2009108860A2 (en) * | 2008-02-28 | 2009-09-03 | The Ohio University Rasearch Foundation | Microrna-based methods and compositions for the diagnosis, pronosis and treatment of prostate related disorders |
WO2009109665A1 (en) | 2008-03-07 | 2009-09-11 | Santaris Pharma A/S | Pharmaceutical compositions for treatment of microrna related diseases |
CN102036689B (zh) | 2008-03-17 | 2014-08-06 | 得克萨斯系统大学董事会 | 神经肌肉突触维持和再生中涉及的微小rna的鉴定 |
US8252760B2 (en) | 2008-03-24 | 2012-08-28 | New York University | Compositions and methods for diagnosing and treating melanoma |
EP2271757A2 (en) * | 2008-03-26 | 2011-01-12 | Asuragen, INC. | Compositions and methods related to mir-16 and therapy of prostate cancer |
US8741861B2 (en) * | 2008-03-27 | 2014-06-03 | Vascular Biosciences | Methods of novel therapeutic candidate identification through gene expression analysis in vascular-related diseases |
US9179654B2 (en) * | 2008-04-07 | 2015-11-10 | Cornell Research Foundation, Inc. | Inhibition of angiogenesis |
WO2009126726A1 (en) * | 2008-04-08 | 2009-10-15 | Asuragen, Inc | Methods and compositions for diagnosing and modulating human papillomavirus (hpv) |
CA2723716A1 (en) * | 2008-05-07 | 2009-11-12 | Abraxis Bioscience, Llc | Enhancement of drug therapy by mirna |
US8258111B2 (en) | 2008-05-08 | 2012-09-04 | The Johns Hopkins University | Compositions and methods related to miRNA modulation of neovascularization or angiogenesis |
WO2009137801A2 (en) * | 2008-05-08 | 2009-11-12 | The Trustees Of Columbia University In The City Of New York | Inhibitory rnas that regulate hematopoietic cells |
WO2009147658A2 (en) * | 2008-06-02 | 2009-12-10 | New York University | Compositions and methods for diagnosis, prognosis and treatment of mesothelioma |
WO2009149318A2 (en) * | 2008-06-05 | 2009-12-10 | Research Foundation Of State University Of New York | Mirnas as therapeutic targets in cancer |
US8900627B2 (en) * | 2008-06-06 | 2014-12-02 | Mirna Therapeutics, Inc. | Compositions for the in vivo delivery of RNAi agents |
US8247388B2 (en) * | 2008-06-06 | 2012-08-21 | The Board Of Trustees Of The Leland Stanford Junior University | Role of miRNA in T cell leukemia |
US9125923B2 (en) | 2008-06-11 | 2015-09-08 | The Ohio State University | Use of MiR-26 family as a predictive marker for hepatocellular carcinoma and responsiveness to therapy |
US8252534B2 (en) * | 2008-06-12 | 2012-08-28 | City Of Hope | Micro RNAs and their methods of use for the treatment and diagnosis of schizophrenia and schizophrenia spectrum disorders |
WO2009153775A2 (en) * | 2008-06-17 | 2009-12-23 | Rosetta Genomics Ltd. | Methods for distinguishing between specific types of lung cancers |
US9540695B2 (en) | 2008-06-17 | 2017-01-10 | Rosetta Genomics Ltd. | Compositions and methods for prognosis of ovarian cancer |
MX2010014242A (es) | 2008-06-27 | 2011-06-24 | Edrich Miescher Inst For Biomedical Res Novartis Forschungsstiftung Zweigniederlassung Fri | Prediccion de la respuesta a terapia antiviral. |
BRPI0913657A2 (pt) | 2008-07-01 | 2020-08-04 | Monsanto Technology Llc | constructos de dna recombinante e métodos para a modulação da expressão de um gene-alvo |
EP2314678B1 (en) * | 2008-07-03 | 2017-02-15 | National University Corporation Kobe University | Micro-rna associated with rheumatoid arthritis |
ES2541442T3 (es) | 2008-08-01 | 2015-07-20 | Roche Innovation Center Copenhagen A/S | Modulación mediada por microARN de factores estimulantes de colonias |
KR101042052B1 (ko) * | 2008-08-05 | 2011-06-16 | 사회복지법인 삼성생명공익재단 | 항-microRNA를 포함하는 고형암 예방 또는 치료용조성물 |
US20110280861A1 (en) * | 2008-08-08 | 2011-11-17 | Massachusetts Institute Of Technology | Method for mir-125a in promoting hematopoietic stem cell self renewal and expansion |
US8685937B2 (en) | 2008-08-09 | 2014-04-01 | University Of Iowa Research Foundation | Nucleic acid aptamers |
WO2010019574A1 (en) * | 2008-08-11 | 2010-02-18 | The Board Of Regents Of The University Of Texas System | A micro-rna that promotes vascular integrity and uses thereof |
CA2734179A1 (en) * | 2008-08-12 | 2010-02-18 | The Ohio State University Research Foundation | Micro-rna-based compositions and methods for the diagnosis, prognosis and treatment of multiple myeloma |
US20120149586A1 (en) * | 2008-08-15 | 2012-06-14 | Scottsdale Healthcare | Methods of predicting the risk of recurrence of cancer |
EP2326730B1 (en) * | 2008-08-19 | 2014-03-19 | Maine Institute For Human Genetics And Health | Micro rna (mirna) and neurofibromatosis type 1 : a role in diagnosis and therapy |
US20120040851A1 (en) | 2008-09-19 | 2012-02-16 | Immune Disease Institute, Inc. | miRNA TARGETS |
US8748101B2 (en) * | 2008-11-10 | 2014-06-10 | Battelle Memorial Institute | Methods, compositions, and devices utilizing MicroRNA to determine physiological conditions |
WO2010056737A2 (en) * | 2008-11-11 | 2010-05-20 | Mirna Therapeutics, Inc. | Methods and compositions involving mirnas in cancer stem cells |
US20120041048A1 (en) | 2008-12-05 | 2012-02-16 | Whitehead Institute For Biomedical Research | COMPOSITIONS AND METHODS RELATING TO miR-31 |
EP2633854B1 (en) | 2008-12-05 | 2015-09-16 | Yeda Research And Development Co. Ltd. | miRNA-9 or miRNA-9* for use in treating ALS |
EP2208785A1 (en) | 2009-01-15 | 2010-07-21 | Newbiotechnic, S.A. | Methods and kits to generate miRNA- and smallRNA-expressing vectors, and its application to develop lentiviral expression libraries |
EP2379720B1 (en) | 2009-01-20 | 2016-08-17 | Alona Zilberberg | Mir-21 promoter driven targeted cancer therapy |
CN102388149A (zh) | 2009-02-02 | 2012-03-21 | 西菲伊德公司 | 检测败血症的方法 |
KR20110128838A (ko) | 2009-02-04 | 2011-11-30 | 보드 오브 리전츠 더 유니버시티 오브 텍사스 시스템 | 심장 질환 치료에서 mir-208 및 mir-499의 이중 표적화 |
EP2218458A1 (en) * | 2009-02-13 | 2010-08-18 | Fondazione Telethon | Molecules able to modulate the expression of at least a gene involved in degradative pathways and uses thereof |
US20100311815A1 (en) * | 2009-02-23 | 2010-12-09 | The Regents Of The University Of Michigan | Mir-101 cancer markers |
AU2010218147A1 (en) * | 2009-02-26 | 2011-10-20 | The Government Of The United States Of America As Represented By The Secretary Of The Dept. Of Health & Human Services | MicroRNAs in never-smokers and related materials and methods |
SG174455A1 (en) * | 2009-03-19 | 2011-10-28 | Agency Science Tech & Res | Modulators of apoptosis and the uses thereof |
US20120087992A1 (en) * | 2009-03-20 | 2012-04-12 | Jingfang Ju | miRNAS AS THERAPEUTIC TARGETS IN CANCER |
JP2012522508A (ja) | 2009-03-31 | 2012-09-27 | ザ ユナイテッド ステイツ オブ アメリカ, アズ リプレゼンテッド バイ ザ セクレタリー, デパートメント オブ ヘルス アンド ヒューマン サービシーズ | シェーグレン症候群の診断および治療のためのバイオマーカーとしての示差的に発現されるマイクロrna |
WO2010120969A1 (en) * | 2009-04-15 | 2010-10-21 | Board Of Regents, The University Of Texas System | Targeting of the mir-30 family and let-7 family as a treatment for heart disease |
ES2599979T3 (es) | 2009-04-24 | 2017-02-06 | Roche Innovation Center Copenhagen A/S | Composiciones farmacéuticas para el tratamiento de pacientes de VHC que no responden al interferón |
JP5871791B2 (ja) * | 2009-04-29 | 2016-03-01 | アカデミス・メディス・セントルム・ベイ・デ・ウニフェルジテイト・ファン・アムステルダムAcademisch Medisch Centrum Bij De Universiteit Van Amsterdam | 心不全または心不全の危険性を中和、予防および/または決定する手段および方法 |
WO2010127186A1 (en) | 2009-04-30 | 2010-11-04 | Prognosys Biosciences, Inc. | Nucleic acid constructs and methods of use |
WO2010129919A1 (en) * | 2009-05-08 | 2010-11-11 | Research Development Foundation | Mirna expression in allergic disease |
CA2761411A1 (en) * | 2009-05-08 | 2010-11-11 | The Ohio State University Research Foundation | Microrna expression profiling and targeting in chronic obstructive pulmonary disease (copd) lung tissue and methods of use thereof |
US8924232B2 (en) * | 2009-05-11 | 2014-12-30 | Koninklijke Philips N.V. | Device and method for comparing molecular signatures |
WO2010133970A1 (en) | 2009-05-20 | 2010-11-25 | Eth Zurich | Targeting micrornas for metabolic disorders |
JP2012527478A (ja) * | 2009-05-20 | 2012-11-08 | ボード・オブ・リージエンツ,ザ・ユニバーシテイ・オブ・テキサス・システム | 心筋梗塞後のリモデリングおよび心不全に関与するマイクロrnaの同定 |
DK2435583T3 (da) * | 2009-05-25 | 2014-09-29 | Universit Degli Studi Di Roma La Sapienza | miR-31 VED BEHANDLING AF DUCHENNES MUSKELDYSTROFI |
US20120059159A1 (en) * | 2009-05-25 | 2012-03-08 | Carola Ponzetto | Differentiation therapy for sarcomas |
WO2010144698A2 (en) * | 2009-06-10 | 2010-12-16 | Henry Ford Health System | Methods, systems, and compositions for neuronal differentiation of multipotent stromal cells |
US20100322909A1 (en) | 2009-06-17 | 2010-12-23 | The University Of Pittsburgh - Of The Commonwealth System Of Higher Education | Th1-associated micrornas and their use for tumor immunotherapy |
WO2010151755A2 (en) * | 2009-06-25 | 2010-12-29 | The Brigham And Women's Hospital, Inc. | TREATMENT OF INFLAMMATORY DISEASES USING miR-124 |
WO2011012136A1 (en) * | 2009-07-28 | 2011-02-03 | Exiqon A/S | A method for classifying a human cell sample as cancerous |
FR2948687B1 (fr) * | 2009-07-29 | 2015-09-04 | Centre Nat Rech Scient | Utilisation de microarn pour le traitement de pathologies respiratoires chroniques |
EP2460005A4 (en) | 2009-07-31 | 2012-11-21 | Translational Genomics Res Inst | METHOD FOR ASSESSING A CANCER PROGRESSION RISK |
WO2011017516A2 (en) * | 2009-08-05 | 2011-02-10 | Curna, Inc. | Treatment of insulin gene (ins) related diseases by inhibition of natural antisense transcript to an insulin gene (ins) |
US20120214863A1 (en) * | 2009-08-05 | 2012-08-23 | The Ohio State University Research Foundation | Anti-miR-1 Therapy for Wound Healing |
EP2283846A1 (en) * | 2009-08-12 | 2011-02-16 | Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. | miRNA compounds for treatment of prostate carcinoma |
US8796238B2 (en) | 2009-09-17 | 2014-08-05 | Sigma-Aldrich Co. Llc | Short RNA mimetics |
WO2011047147A1 (en) * | 2009-10-14 | 2011-04-21 | Baylor College Of Medicine | Microrna mirna-31 as a therapeutic approach for the treatment of cancer |
US8841273B2 (en) * | 2009-10-28 | 2014-09-23 | Board Of Regents, The University Of Texas System | Methods and compositions for anti-EGFR treatment |
EP3118334A1 (en) | 2009-11-04 | 2017-01-18 | DiamiR, LLC | Methods of using small rna from bodily fluids for diagnosis and monitoring of neurodegenerative diseases |
US8916533B2 (en) | 2009-11-23 | 2014-12-23 | The Ohio State University | Materials and methods useful for affecting tumor cell growth, migration and invasion |
US20130090366A1 (en) * | 2009-11-24 | 2013-04-11 | Peter Jeffery Leedman | Modulation of epidermal growth factor receptor ligands |
EP2327783A1 (en) * | 2009-11-27 | 2011-06-01 | Universitätsklinikum Freiburg | Pharmaceutical composition comprising miRNA-100 and its use in the modulation of blood vessel growth |
US8354520B2 (en) * | 2009-12-10 | 2013-01-15 | Kaohsiung Medical University | Composition and method for treating atherosclerosis, method for determining if a subject has atherosclerosis and method of screening an anti-atherosclerotic drug |
US20120315640A1 (en) | 2009-12-21 | 2012-12-13 | Hidetoshi Tahara | Senescence marker, method for evaluating senescence inhibitor, and cancer inhibitor |
WO2011084815A1 (en) * | 2009-12-21 | 2011-07-14 | Board Of Trustees Of Southern Illinois University | Inhibition of ubc9-mediated cancer cell invasion and metastasis |
EP2518144B1 (en) * | 2009-12-21 | 2015-08-05 | Hiroshima University | Aging marker, method for evaluating aging inhibitor, and cancer inhibitor |
US20130012403A1 (en) * | 2009-12-23 | 2013-01-10 | George Washington University | Compositions and Methods for Identifying Autism Spectrum Disorders |
EP2341145A1 (en) * | 2009-12-30 | 2011-07-06 | febit holding GmbH | miRNA fingerprint in the diagnosis of diseases |
WO2011088309A1 (en) | 2010-01-14 | 2011-07-21 | Regulus Therapeutics Inc. | Microrna compositions and methods |
WO2011091209A1 (en) * | 2010-01-21 | 2011-07-28 | North Carolina State University | Small molecule modifiers of microrna mir-122 |
JP2011188849A (ja) * | 2010-02-18 | 2011-09-29 | Okayama Univ | 抗腫瘍効果を有するmiR−7発現プラスミド |
US8841269B2 (en) * | 2010-02-23 | 2014-09-23 | Creighton University | Polynucleotides for use in treating and diagnosing cancers |
EP3214174B1 (en) * | 2010-03-04 | 2019-10-16 | InteRNA Technologies B.V. | A mirna molecule defined by its source and its diagnostic and therapeutic uses in diseases or conditions associated with emt |
WO2011111715A1 (ja) * | 2010-03-09 | 2011-09-15 | 協和発酵キリン株式会社 | 細胞周期を制御する核酸 |
US20190300945A1 (en) | 2010-04-05 | 2019-10-03 | Prognosys Biosciences, Inc. | Spatially Encoded Biological Assays |
US10787701B2 (en) | 2010-04-05 | 2020-09-29 | Prognosys Biosciences, Inc. | Spatially encoded biological assays |
HUE026666T2 (en) | 2010-04-05 | 2016-07-28 | Prognosys Biosciences Inc | Spatially encoded biological assays |
PT2561078T (pt) | 2010-04-23 | 2018-12-03 | Cold Spring Harbor Laboratory | Sharn com uma conceção estrutural inovadora |
WO2011150420A1 (en) * | 2010-05-28 | 2011-12-01 | Baylor College Of Medicine | Modified gold nanoparticles for therapy |
AU2011261213B2 (en) | 2010-06-04 | 2015-05-21 | Board Of Regents, The University Of Texas System | Regulation of metabolism by miR-378 |
JP5886278B2 (ja) * | 2010-06-09 | 2016-03-16 | シャネル パフュームズ ビューテ | 皮膚の加齢を防止および/もしくは減弱し、並びに/または皮膚に潤いを与えるのに用いるためのマイクロrna阻害剤 |
WO2012005572A1 (en) * | 2010-07-06 | 2012-01-12 | Interna Technologies Bv | Mirna and its diagnostic and therapeutic uses in diseases or conditions associated with melanoma, or in diseases or conditions associated with activated braf pathway |
WO2012008302A1 (ja) | 2010-07-12 | 2012-01-19 | 国立大学法人鳥取大学 | miRNA導入による新規hiPSC作製法 |
US8580513B2 (en) * | 2010-07-20 | 2013-11-12 | Trustees Of Dartmouth College | Methods for determining response to neoadjuvant therapy and survival using MicroRNA-10b |
WO2012012716A2 (en) | 2010-07-23 | 2012-01-26 | Regulus Therapeutics, Inc. | Targeting micrornas for the treatment of fibrosis |
CA2808372C (en) * | 2010-08-16 | 2021-11-16 | Brainstem Biotec Ltd. | Methods of generating oligodendrocytes and cell populations comprising same |
US10385314B2 (en) | 2010-08-16 | 2019-08-20 | Exostem Biotec Ltd. | Methods of generating oligodendrocytes and cell populations comprising same |
CA2807104C (en) * | 2010-08-17 | 2020-03-10 | Universite De Geneve | Bard1 isoforms in lung and colorectal cancer and use thereof |
US8642342B2 (en) | 2010-08-19 | 2014-02-04 | Regents Of The University Of Michigan | Methods for regulating neural differentiation |
EP2426217A1 (en) * | 2010-09-03 | 2012-03-07 | Centre National de la Recherche Scientifique (CNRS) | Analytical methods for cell free nucleic acids and applications |
US9006195B2 (en) * | 2010-09-13 | 2015-04-14 | California Institute Of Technology | Regulation of hematopoietic stem cell functions through microRNAs |
CA2812650C (en) * | 2010-09-27 | 2019-11-05 | Sabanci Universitesi | Use of mirnas for the diagnosis, prophylaxis, treatment and follow-up of diseases involving macroautophagy abnormalities |
WO2012041959A1 (en) | 2010-09-30 | 2012-04-05 | University Of Zurich | Treatment of b-cell lymphoma with microrna |
WO2012065049A1 (en) * | 2010-11-12 | 2012-05-18 | The Ohio State University Research Foundation | Materials and methods related to microrna-21, mismatch repair, and colorectal cancer |
WO2012063894A1 (ja) * | 2010-11-12 | 2012-05-18 | 国立大学法人愛媛大学 | マイクロrnaのアンチセンスオリゴヌクレオチドを含む組成物 |
CA2817982C (en) | 2010-11-15 | 2020-06-30 | The Regents Of The University Of Michigan | Controlled release mucoadhesive systems |
ES2629890T3 (es) | 2010-11-17 | 2017-08-16 | Interpace Diagnostics, Llc | miARN como biomarcadores para distinguir entre neoplasias de tiroides benignas y malignas |
EP2942403B1 (en) * | 2010-12-01 | 2017-04-12 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Method for predicting the outcome of a cancer by analysing mirna expression |
US11414663B2 (en) | 2010-12-01 | 2022-08-16 | Gowey Research Group, Pllc | Micro-RNA profiling, compositions, and methods of treating diseases |
US10758578B2 (en) | 2010-12-01 | 2020-09-01 | Gowey Research Group PLLC | Herbal formulations of carnivorous plants and methods for treating inflammation |
US11344505B1 (en) | 2010-12-01 | 2022-05-31 | Gowey Research Group, Pllc | Herbal formulations of carnivorous plants and methods for treating inflammation |
US10744151B1 (en) * | 2010-12-01 | 2020-08-18 | Gowey Research Group PLLC | Micro-RNA profiling, compositions, and methods of treating diseases |
CA2821952A1 (en) * | 2010-12-15 | 2012-06-21 | Medimmune, Llc | Melanoma treatments |
MX2013005875A (es) | 2010-12-15 | 2014-04-30 | Miragen Therapeutics | Inhibidores de microarn que comprenden nucleotidos bloqueados. |
WO2012087242A1 (en) * | 2010-12-20 | 2012-06-28 | Agency For Science, Technology And Research | Targeting glioma stem cells by sequence-specific functional inhibition of pro-survival oncomir-138 |
EP2474617A1 (en) | 2011-01-11 | 2012-07-11 | InteRNA Technologies BV | Mir for treating neo-angiogenesis |
CA2826043A1 (en) | 2011-02-03 | 2012-08-09 | Mirna Therapeutics, Inc. | Synthetic mimics of mir-124 |
CN103476931A (zh) | 2011-02-03 | 2013-12-25 | 米尔纳医疗股份有限公司 | Mir-34的合成模拟物 |
HUE045731T2 (hu) * | 2011-02-07 | 2020-01-28 | Gabriella Sozzi | Mikro-RNS biomarkerek tüdõtumor diagnosztizálásához és/vagy kockázatának azonosításához |
US8664192B2 (en) | 2011-03-07 | 2014-03-04 | The Ohio State University | Mutator activity induced by microRNA-155 (miR-155) links inflammation and cancer |
WO2012133947A1 (en) * | 2011-03-30 | 2012-10-04 | Riken | Functional nucleic acid molecule and use thereof |
EP2691548B1 (en) * | 2011-03-31 | 2017-11-22 | University of Houston | Microrna 130a,b as a tumor suppressor and sensitizing agent for chemotherapy |
WO2012140234A1 (en) | 2011-04-13 | 2012-10-18 | Vib Vzw | Modulation of mirna in diseases with aberrant angiogenesis |
GB201106254D0 (en) | 2011-04-13 | 2011-05-25 | Frisen Jonas | Method and product |
US9556487B2 (en) | 2011-04-18 | 2017-01-31 | Diamir, Llc | Methods of using miRNA from bodily fluids for early detection and monitoring of mild cognitive impairment (MCI) and alzheimer's disease (AD) |
WO2012145743A1 (en) * | 2011-04-22 | 2012-10-26 | University Of Houston | Microrna-140-5p as a tumor suppressor and sensitizing agent for chemotherapy |
TWI607016B (zh) | 2011-04-25 | 2017-12-01 | 瑞格勒斯治療學公司 | 微型rna化合物及調控mir-21活性之方法 |
EE201100037A (et) * | 2011-05-16 | 2012-12-17 | Tartu Ülikool | MikroRNAde kasutamine biomarkeritena ja sihtmrkidena raku proliferatiivsete omaduste m?jutamiseks ja meetod ning komplekt nende ekspressioonitaseme tuvastamiseks |
KR102066295B1 (ko) | 2011-06-27 | 2020-01-14 | 갈데르마 리써어치 앤드 디벨로프먼트 | 신규한 여드름용 th17 분화 마커 및 이의 용도 |
JP6366503B2 (ja) * | 2011-06-27 | 2018-08-01 | ガルデルマ・リサーチ・アンド・デヴェロップメント | ざ瘡についての新規th17分化マーカーおよびその使用 |
US8747860B2 (en) | 2011-07-06 | 2014-06-10 | Institute For Systems Biology | Methods and compositions to modulate antiviral and immune activity responses |
WO2013019259A1 (en) | 2011-08-01 | 2013-02-07 | Thomson Licensing | Telepresence communications system and method |
HUE033746T2 (en) | 2011-08-04 | 2018-01-29 | Yeda Res & Dev | MIR-135 and compositions thereof for the treatment of therapeutic conditions associated with serotonin |
US8987224B2 (en) | 2011-08-05 | 2015-03-24 | Baylor College Of Medicine | MicroRNA-198 as a tumor suppressor in pancreatic cancer |
US20140199402A1 (en) | 2011-08-12 | 2014-07-17 | Alexander Schmidt | Novel compounds for the treatment of inflammatory bowel disease |
WO2013032962A2 (en) * | 2011-08-28 | 2013-03-07 | The Board Of Trustees Of The Leland Stanford Junior University | Micro rnas to treat stroke, ischemic brain injury, traumatic brain injury, and neurodegenerative disease |
WO2013030362A1 (en) * | 2011-08-31 | 2013-03-07 | Universität Zürich Prorektorat Mnw | Modulators of mir-323-3p for the prevention or treatment of rheumatoid arthritis |
EP2755663A4 (en) | 2011-09-13 | 2015-10-07 | Ottawa Hospital Res Inst | INHIBITORS OF MICRO-ARNMICRORNA INHIBITORS |
WO2013040251A2 (en) | 2011-09-13 | 2013-03-21 | Asurgen, Inc. | Methods and compositions involving mir-135b for distinguishing pancreatic cancer from benign pancreatic disease |
JP6177243B2 (ja) | 2011-10-06 | 2017-08-09 | ミラゲン セラピューティクス, インコーポレイテッド | マイクロrnaの調節による全身エネルギーホメオスタシスの制御 |
WO2013056217A1 (en) | 2011-10-14 | 2013-04-18 | The Ohio State University | Methods and materials related to ovarian cancer |
EP2584040A1 (en) | 2011-10-17 | 2013-04-24 | Pharmahungary 2000 Kft. | Compounds for treatment of ischemic injury |
WO2013065791A1 (ja) * | 2011-11-02 | 2013-05-10 | 公立大学法人大阪市立大学 | 遺伝子発現抑制用二本鎖核酸分子 |
WO2013082499A1 (en) * | 2011-11-30 | 2013-06-06 | Cedars-Sinai Medical Center | Targeting micrornas mir-409-5p, mir-379 and mir-154* to treat prostate cancer bone metastasis and drug resistant lung cancer |
EP2785872A4 (en) * | 2011-12-01 | 2015-12-09 | Univ Ohio State | MATERIALS AND METHODS RELATED TO NSAID CHEMOPRVENTION IN COLORECTAL CANCER |
AU2012347498A1 (en) * | 2011-12-10 | 2014-06-26 | Ohio State Innovation Foundation | MiRNAs useful to reduce lung cancer tumorigenesis and chemotherapy resistance and related compositons and methods |
CA2859430A1 (en) * | 2011-12-13 | 2013-06-20 | Ohio State Innovation Foundation | Methods and compositions related to mir-21 and mir-29a, exosome inhibition, and cancer metastasis |
ITRM20110685A1 (it) | 2011-12-23 | 2013-06-24 | Internat Ct For Genetic En Gineering And | Microrna per la rigenerazione cardiaca attraverso l induzione della proliferazione dei miociti cardiaci |
WO2013110053A1 (en) | 2012-01-20 | 2013-07-25 | The Ohio State University | Breast cancer biomarker signatures for invasiveness and prognosis |
US9803175B2 (en) | 2012-02-22 | 2017-10-31 | Exostem Biotec Ltd. | Generation of neural stem cells and motor neurons |
EP3401393B1 (en) | 2012-02-22 | 2020-02-19 | Exostem Biotec Ltd | Micrornas for the generation of astrocytes |
WO2013133863A1 (en) | 2012-03-09 | 2013-09-12 | Thomson Licensing | Distributed control of synchronized content |
IN2014DN09134A (es) | 2012-04-25 | 2015-05-22 | Regulus Therapeutics Inc | |
WO2013166240A1 (en) * | 2012-05-02 | 2013-11-07 | The Board Of Regents Of The University Of Texas System | Micro-rnas involved in macular degeneration |
WO2013170146A1 (en) | 2012-05-10 | 2013-11-14 | Uab Research Foundation | Methods and compositions for modulating mir-204 activity |
US9663784B2 (en) | 2012-05-26 | 2017-05-30 | Bonac Corporation | Single-stranded nucleic acid molecule for regulating expression of gene having delivering function |
US9163235B2 (en) | 2012-06-21 | 2015-10-20 | MiRagen Therapeutics, Inc. | Inhibitors of the miR-15 family of micro-RNAs |
EP2864482A4 (en) | 2012-06-21 | 2016-02-10 | Miragen Therapeutics Inc | OLIGONUCLEOTIDE INHIBITORS COMPRISING A BLOCKED NUCLEIC ACID PATTERN |
CN104603272B (zh) * | 2012-07-06 | 2017-11-07 | 宝生物工程株式会社 | 能够产生腺伴随病毒载体的细胞 |
SG11201500615WA (en) | 2012-07-27 | 2015-04-29 | Agency Science Tech & Res | Method of promoting wound healing |
EP2879678B1 (en) | 2012-07-31 | 2023-03-01 | Yeda Research and Development Co. Ltd. | Enoxacin for treating amyotrophic lateral sclerosis |
EP2703498B1 (en) * | 2012-08-29 | 2015-01-14 | Chanel Parfums Beauté | Inhibitors of micro-RNAs for use for preventing and/or attenuating skin ageing |
EP2702998A1 (en) | 2012-08-31 | 2014-03-05 | IMBA-Institut für Molekulare Biotechnologie GmbH | Therapeutic and diagnostic miRNA regulator in kidney disease |
WO2014043159A1 (en) * | 2012-09-11 | 2014-03-20 | New York University | Sera based mirnas as non-invasive biomarkers in melanoma |
UA116639C2 (uk) | 2012-10-09 | 2018-04-25 | Рег'Юлес Терап'Ютікс Інк. | Способи лікування синдрому альпорта |
WO2014071205A1 (en) * | 2012-11-02 | 2014-05-08 | Dana-Farber Cancer Institute, Inc. | Compositions and methods for diagnosis, prognosis and treatment of hematological malignancies |
US9340787B2 (en) * | 2012-11-15 | 2016-05-17 | Yale University | Compositions and methods of using micro RNAs |
WO2014099999A1 (en) * | 2012-12-18 | 2014-06-26 | Sanford-Burnham Medical Research Institute | Methods for improving cardiac contractility |
JP6587142B2 (ja) * | 2013-02-15 | 2019-10-09 | 国立大学法人 東京医科歯科大学 | マイクロrnaからなるがん治療剤 |
WO2014164753A1 (en) * | 2013-03-11 | 2014-10-09 | Emory University | Methods and compositions for managing vascular conditions |
US9006200B2 (en) * | 2013-03-13 | 2015-04-14 | Asbestos Diseases Research Foundation | MicroRNA-based approach to treating malignant pleural mesothelioma |
WO2014140856A2 (en) | 2013-03-15 | 2014-09-18 | Graham Lord | Mir-142 and antagonists thereof for treating disease |
WO2014152243A1 (en) * | 2013-03-15 | 2014-09-25 | Albert Einstein College Of Medicine Of Yeshiva University | Panel of microrna biomarkers in healthy aging |
CA2902623A1 (en) | 2013-03-15 | 2014-09-25 | MiRagen Therapeutics, Inc. | Locked nucleic acid inhibitor of mir-145 and uses thereof |
AU2014228166A1 (en) | 2013-03-15 | 2015-09-24 | Mirna Therapeutics, Inc. | Combination cancer treatments utilizing micrornas and EGFR-TKI inhibitors |
US9756288B2 (en) | 2013-04-10 | 2017-09-05 | Thomson Licensing | Tiering and manipulation of peer's heads in a telepresence system |
JP2016169158A (ja) * | 2013-06-14 | 2016-09-23 | 北海道公立大学法人 札幌医科大学 | 大腸癌を治療および/または診断するための組成物ならびにその利用 |
GB201310755D0 (en) * | 2013-06-17 | 2013-07-31 | Ucl Business Plc | Therapy |
KR20160022307A (ko) | 2013-06-20 | 2016-02-29 | 톰슨 라이센싱 | 콘텐츠의 분산 재생의 동기화를 지원하기 위한 시스템 및 방법 |
MX2015017749A (es) | 2013-06-24 | 2016-04-04 | Mirna Therapeutics Inc | Biomarcadores de actividad mir-34. |
CA2916660C (en) | 2013-06-25 | 2022-05-17 | Prognosys Biosciences, Inc. | Spatially encoded biological assays using a microfluidic device |
US9862943B1 (en) * | 2013-06-27 | 2018-01-09 | California Institute Of Technology | Long noncoding RNAs and cell reprogramming and differentiation |
JP6443889B2 (ja) * | 2013-08-08 | 2018-12-26 | 国立大学法人大阪大学 | 尿路上皮癌の診断または治療剤 |
KR101566586B1 (ko) * | 2013-08-21 | 2015-11-16 | 서울대학교산학협력단 | miRNA를 표적으로 하는 뇌전증 또는 발작 관련 질환의 예방 또는 치료용 약학 조성물 및 방법 |
EP3049522A2 (en) * | 2013-09-26 | 2016-08-03 | Friedrich Miescher Institute for Biomedical Research | Tools and methods using mirna 182, 96 and/or 183 for treating pathologies |
US20150089870A1 (en) * | 2013-10-01 | 2015-04-02 | Wayne State University | Population control of invasive plant species and restoration of native plant communities |
KR101598070B1 (ko) * | 2013-10-17 | 2016-02-26 | 한국과학기술연구원 | 마약 중독 예방 및 치료용 약제학적 조성물 |
US10087443B2 (en) | 2013-10-28 | 2018-10-02 | Icahn School Of Medicine At Mount Sinai | Compositions and methods for modulating neuronal excitability and motor behavior |
KR101559131B1 (ko) * | 2013-11-18 | 2015-10-07 | 한국원자력의학원 | miRNA를 포함하는 방사선 민감성 증진용 조성물 |
US11098362B2 (en) | 2013-11-18 | 2021-08-24 | Diamir, Llc | Methods of using miRNAs from bodily fluids for detection and monitoring of Parkinson's disease (PD) |
EP3178943B1 (en) | 2013-12-17 | 2018-10-03 | Csir | A method for identification of anti-hiv human mirna mimics and mirna inhibitors and anti-hiv pharmaceutical compounds |
EP3088524A4 (en) | 2013-12-26 | 2017-08-09 | Tokyo Medical University | Artificial mimic mirna for controlling gene expression, and use of same |
JP6492014B2 (ja) * | 2013-12-27 | 2019-03-27 | 株式会社ボナック | 遺伝子発現制御のための人工マッチ型miRNAおよびその用途 |
RU2697094C2 (ru) * | 2013-12-27 | 2019-08-12 | Бонак Корпорейшн | ИСКУССТВЕННАЯ мкРНК С СООТВЕТСТВИЕМ ДЛЯ КОНТРОЛЯ ЭКСПРЕССИИ ГЕНОВ И ЕЕ ПРИМЕНЕНИЕ |
US10125365B2 (en) | 2014-02-05 | 2018-11-13 | Yeda Research And Development Co. Ltd. | Micro-RNAs and compositions comprising same for the treatment and diagnosis of serotonin-, adrenalin-, noradrenalin-, glutamate-, and corticotropin-releasing hormone- associated medical conditions |
JPWO2015133637A1 (ja) * | 2014-03-07 | 2017-04-06 | 国立大学法人京都大学 | マイクロrna封入ナノ粒子及びその医薬用途 |
WO2015153757A1 (en) | 2014-04-01 | 2015-10-08 | Mirna Therapeutics, Inc. | Microrna dosing regimens |
EP3444362B1 (en) * | 2014-05-02 | 2020-12-09 | Ruprecht-Karls-Universität Heidelberg | Circulating mirnas as early detection marker and prognostic marker |
DK3161165T3 (da) * | 2014-06-26 | 2021-01-11 | Icahn School Med Mount Sinai | Fremgangsmåde til diagnosticering af subklinisk og klinisk akut afstødning ved analyse af prædiktive gensæt, terapeutisk middel til anvendelse ved behandlingen og kits til at bestemme ekspressionen |
WO2016010023A1 (ja) * | 2014-07-15 | 2016-01-21 | 株式会社ミツバ | ブラシレスワイパモータ |
LU92499B1 (en) | 2014-07-16 | 2016-01-18 | Univ Muenster Wilhelms | Mirna 320a as biomarker for inflammatory bowel disease |
ES2558262B2 (es) | 2014-08-01 | 2016-07-14 | Universidad Católica De Valencia "San Vicente Mártir" | Método de diagnóstico de fibromialgia basado en microRNAs |
MX2017001493A (es) | 2014-08-07 | 2017-05-09 | Regulus Therapeutics Inc | Eleccion de micro acidos ribonucleicos (arn) como diana para trastornos metabolicos. |
WO2016054094A1 (en) * | 2014-09-30 | 2016-04-07 | Research Institute At Nationwide Children's Hospital | Compositions and methods for treating hepatic fibrosis |
BR112017013664A2 (pt) | 2014-12-27 | 2018-03-13 | Bonac Corporation | mirna de tipo natural, composição, métodos para inibir expressão de um gene alvo e para tratar uma doença, e, ácido nucleico de fita simples. |
SG11201705907XA (en) | 2015-01-20 | 2017-08-30 | Miragen Therapeutics Inc | Mir-92 inhibitors and uses thereof |
GB201504772D0 (en) | 2015-03-20 | 2015-05-06 | Univ Aston | Preeclampsia |
US20180064748A1 (en) | 2015-03-27 | 2018-03-08 | Yeda Research And Development Co. Ltd. | Methods of treating motor neuron diseases |
EP3276003B1 (en) | 2015-03-27 | 2022-07-20 | Bonac Corporation | Single-chain nucleic acid molecule having delivery function and gene expression control ability |
US10774374B2 (en) | 2015-04-10 | 2020-09-15 | Spatial Transcriptomics AB and Illumina, Inc. | Spatially distinguished, multiplex nucleic acid analysis of biological specimens |
EP3284822A1 (en) * | 2015-04-17 | 2018-02-21 | The University of Tokyo | Therapeutic agent for eye disease |
WO2016183414A1 (en) * | 2015-05-14 | 2016-11-17 | The Arizona Board Of Regents On Behalf Of The University Of Arizona | Systems and methods for characterizing granulomatous diseases |
WO2016190899A1 (en) * | 2015-05-23 | 2016-12-01 | Beem Alan M H | Pri-mirna libraries and methods for making and using pri-mirna libraries |
WO2017020009A1 (en) * | 2015-07-30 | 2017-02-02 | Regents Of The University Of Minnesota | Regulation of mesodermal specification |
US10450569B2 (en) | 2015-08-13 | 2019-10-22 | Somagenics, Inc. | Methods and compositions of short small hairpin RNAS and microRNAS for wound healing |
EP3337899A1 (en) * | 2015-08-21 | 2018-06-27 | Universitätsklinikum Jena | Human micrornas for treatment of malignant tumours |
JPWO2017057312A1 (ja) | 2015-09-28 | 2018-07-26 | 国立大学法人千葉大学 | miR−200ファミリー阻害により腫瘍を抑制する方法 |
EP3356553A1 (en) | 2015-09-29 | 2018-08-08 | The Research Institute at Nationwide Children's Hospital | Methods for detecting hepatic fibrosis and responsiveness to therapy |
JP6666002B2 (ja) * | 2015-10-07 | 2020-03-13 | 国立大学法人京都大学 | Tdp−43プロテノパシーの予防又は治療用組成物 |
CA3007744C (en) * | 2015-12-10 | 2022-05-17 | Universitat Fur Bodenkultur Wien | Compositions and methods for the diagnosis and treatment of bone fractures and disorders |
EP3181698A1 (en) | 2015-12-16 | 2017-06-21 | European Molecular Biology Laboratory (EMBL) | Microrna mir-142 as stem cell marker |
CA3001536A1 (en) * | 2015-12-28 | 2017-07-06 | Riken | Compositions for use in recovering or ameliorating deterioration of physiological functions due to aging |
US10975436B2 (en) | 2016-01-05 | 2021-04-13 | Diamir, Llc | Methods of using miRNA from bodily fluids for diagnosis and monitoring of neurodevelopmental disorders |
CN105543225A (zh) * | 2016-01-07 | 2016-05-04 | 华东师范大学 | miR143及其诱导物LTA在制备抑制痤疮炎症药物中的应用 |
US10771508B2 (en) | 2016-01-19 | 2020-09-08 | Nadejda Sarmova | Systems and methods for establishing a virtual shared experience for media playback |
CA3016592A1 (en) * | 2016-03-04 | 2017-09-08 | Rhode Island Hospital | Targeting microrna for cancer treatment |
WO2017165458A1 (en) | 2016-03-21 | 2017-09-28 | Diamir, Llc | Methods of using mirnas from bodily fluids for detection and differentiation of neurodegenerative diseases |
US11041152B2 (en) * | 2016-04-14 | 2021-06-22 | E-Na Biotec Inc. | MicroRNA-143 derivative |
WO2017192601A1 (en) * | 2016-05-02 | 2017-11-09 | University Of Massachusetts | T cell differentiation and function regulation |
CA3066107A1 (en) * | 2016-06-03 | 2017-12-07 | Hough Ear Institute | Combination therapies for inner ear sensory hair cell regeneration/replacement |
CA3041761A1 (en) | 2016-10-31 | 2018-05-03 | Gifu University | Double-stranded nucleic acid molecule and use thereof |
AU2017353907B2 (en) | 2016-11-01 | 2023-11-30 | The Research Foundation For The State University Of New York | 5-halouracil-modified microRNAs and their use in the treatment of cancer |
CN107058470B (zh) * | 2016-11-03 | 2020-09-01 | 中国人民解放军陆军军医大学 | 一种通过联合miR-136和miR-4791预测急性高山病发病风险的诊断试剂盒 |
AU2017368050A1 (en) | 2016-11-29 | 2019-06-20 | Puretech Lyt, Inc. | Exosomes for delivery of therapeutic agents |
KR102040388B1 (ko) | 2017-04-19 | 2019-11-04 | 선전 구딕스 테크놀로지 컴퍼니, 리미티드 | 광 강도 검출 방법, 장치 및 스마트 단말기 |
WO2018199231A1 (ja) * | 2017-04-28 | 2018-11-01 | 一丸ファルコス株式会社 | プラセンタ抽出物 |
WO2018204829A1 (en) * | 2017-05-04 | 2018-11-08 | University Of Maryland, Baltimore | Methods for preventing neural tube defects in diabetic pregnancy |
EP3624825A4 (en) * | 2017-05-19 | 2021-03-10 | Georgia State University Research Foundation, Inc. | RECOMBINANT ONCOLYTIC VIRUS |
US20210139895A1 (en) * | 2017-06-16 | 2021-05-13 | Prostemics Co., Ltd. | Pharmaceutical composition for preventing or treating cancer |
US10781487B2 (en) | 2017-07-24 | 2020-09-22 | Diamir, Llc | miRNA-based methods for detecting and monitoring aging |
WO2019116234A1 (en) | 2017-12-12 | 2019-06-20 | Nestec S.A. | Methods for determining microbiome ribosomal rna composition changes |
US11753639B2 (en) | 2018-03-14 | 2023-09-12 | Beth Israel Deaconess Medical Center | Micro-RNA and obesity |
WO2019195765A1 (en) * | 2018-04-06 | 2019-10-10 | University Of Massachusetts | Mlk-regulated micrornas in angiogenesis and tumor development |
US11519033B2 (en) | 2018-08-28 | 2022-12-06 | 10X Genomics, Inc. | Method for transposase-mediated spatial tagging and analyzing genomic DNA in a biological sample |
KR102115960B1 (ko) * | 2018-11-28 | 2020-05-27 | 송미연 | 인간 중간엽 줄기세포를 갑상선 호르몬 분비세포로 분화 방법 |
US11926867B2 (en) | 2019-01-06 | 2024-03-12 | 10X Genomics, Inc. | Generating capture probes for spatial analysis |
US11649485B2 (en) | 2019-01-06 | 2023-05-16 | 10X Genomics, Inc. | Generating capture probes for spatial analysis |
EP3937986A4 (en) * | 2019-03-11 | 2023-04-12 | Ochsner Health System | MICRORNA REGULATORY NETWORK AS A BIOMARKER OF SEIZURES IN PATIENTS WITH SPONTANEOUS INTRACEREBRAL HEMORRHAGE |
WO2020198137A1 (en) * | 2019-03-25 | 2020-10-01 | The Trustees Of The University Of Pennsylvania | Regenerative therapy based on mirna-302 mimics for enhancing host recovery from pneumonia caused by streptococcus pneumoniae |
US11198908B2 (en) | 2019-06-17 | 2021-12-14 | Biorchestra Co., Ltd. | Method for diagnosis of Alzheimer's disease using microRNA |
US10844380B1 (en) | 2019-06-17 | 2020-11-24 | Biorchestra Co., Ltd. | Uses for prevention or treatment of brain diseases using microrna |
CN110551809A (zh) * | 2019-08-21 | 2019-12-10 | 昆明医科大学第一附属医院 | miR-124在脊髓损伤修复中的用途 |
WO2021092433A2 (en) | 2019-11-08 | 2021-05-14 | 10X Genomics, Inc. | Enhancing specificity of analyte binding |
EP4055185A1 (en) | 2019-11-08 | 2022-09-14 | 10X Genomics, Inc. | Spatially-tagged analyte capture agents for analyte multiplexing |
EP4081302A1 (en) * | 2019-12-23 | 2022-11-02 | University Of Massachusetts | Oligonucleotides for tissue specific gene expression modulation |
DK3891300T3 (da) | 2019-12-23 | 2023-05-22 | 10X Genomics Inc | Fremgangsmåder til rumlig analyse ved anvendelse af rna-template-ligering |
US11702693B2 (en) | 2020-01-21 | 2023-07-18 | 10X Genomics, Inc. | Methods for printing cells and generating arrays of barcoded cells |
US11732299B2 (en) | 2020-01-21 | 2023-08-22 | 10X Genomics, Inc. | Spatial assays with perturbed cells |
US11821035B1 (en) | 2020-01-29 | 2023-11-21 | 10X Genomics, Inc. | Compositions and methods of making gene expression libraries |
US11898205B2 (en) | 2020-02-03 | 2024-02-13 | 10X Genomics, Inc. | Increasing capture efficiency of spatial assays |
US11732300B2 (en) | 2020-02-05 | 2023-08-22 | 10X Genomics, Inc. | Increasing efficiency of spatial analysis in a biological sample |
US11835462B2 (en) | 2020-02-11 | 2023-12-05 | 10X Genomics, Inc. | Methods and compositions for partitioning a biological sample |
US11891654B2 (en) | 2020-02-24 | 2024-02-06 | 10X Genomics, Inc. | Methods of making gene expression libraries |
US11926863B1 (en) | 2020-02-27 | 2024-03-12 | 10X Genomics, Inc. | Solid state single cell method for analyzing fixed biological cells |
US11768175B1 (en) | 2020-03-04 | 2023-09-26 | 10X Genomics, Inc. | Electrophoretic methods for spatial analysis |
EP4093870A4 (en) * | 2020-03-13 | 2024-01-10 | Univ Duke | COMPOSITIONS FOR THE TREATMENT OF ANHS AND ASSOCIATED DISORDERS AND METHODS OF USE THEREOF |
CN115916999A (zh) | 2020-04-22 | 2023-04-04 | 10X基因组学有限公司 | 用于使用靶向rna耗竭进行空间分析的方法 |
AU2021275906A1 (en) | 2020-05-22 | 2022-12-22 | 10X Genomics, Inc. | Spatial analysis to detect sequence variants |
EP4153775A1 (en) | 2020-05-22 | 2023-03-29 | 10X Genomics, Inc. | Simultaneous spatio-temporal measurement of gene expression and cellular activity |
WO2021242834A1 (en) | 2020-05-26 | 2021-12-02 | 10X Genomics, Inc. | Method for resetting an array |
AU2021283174A1 (en) | 2020-06-02 | 2023-01-05 | 10X Genomics, Inc. | Nucleic acid library methods |
AU2021283184A1 (en) | 2020-06-02 | 2023-01-05 | 10X Genomics, Inc. | Spatial transcriptomics for antigen-receptors |
WO2021252499A1 (en) | 2020-06-08 | 2021-12-16 | 10X Genomics, Inc. | Methods of determining a surgical margin and methods of use thereof |
EP4165207A1 (en) | 2020-06-10 | 2023-04-19 | 10X Genomics, Inc. | Methods for determining a location of an analyte in a biological sample |
AU2021294334A1 (en) | 2020-06-25 | 2023-02-02 | 10X Genomics, Inc. | Spatial analysis of DNA methylation |
US11761038B1 (en) | 2020-07-06 | 2023-09-19 | 10X Genomics, Inc. | Methods for identifying a location of an RNA in a biological sample |
CN112190592B (zh) * | 2020-08-25 | 2022-03-11 | 苏州市立医院(北区) | miRNA在制备防治骨关节炎药物的应用、miRNA高表达的外泌体和应用 |
US11926822B1 (en) | 2020-09-23 | 2024-03-12 | 10X Genomics, Inc. | Three-dimensional spatial analysis |
WO2022076774A2 (en) * | 2020-10-08 | 2022-04-14 | The Trustees Of Columbia University In The City Of New York | Treatment and detection of liver fibrosis and liver disease using microrna |
CN112375823B (zh) * | 2020-10-22 | 2022-09-16 | 上海交通大学医学院附属瑞金医院 | miRNA抑制剂在制备治疗和/或预防淋巴瘤的药物中的应用 |
US11827935B1 (en) | 2020-11-19 | 2023-11-28 | 10X Genomics, Inc. | Methods for spatial analysis using rolling circle amplification and detection probes |
EP4121555A1 (en) | 2020-12-21 | 2023-01-25 | 10X Genomics, Inc. | Methods, compositions, and systems for capturing probes and/or barcodes |
WO2022198068A1 (en) | 2021-03-18 | 2022-09-22 | 10X Genomics, Inc. | Multiplex capture of gene and protein expression from a biological sample |
WO2022272269A1 (en) * | 2021-06-22 | 2022-12-29 | The Curators Of The University Of Missouri | Multianalyte biomarkers for lung cancer |
EP4196605A1 (en) | 2021-09-01 | 2023-06-21 | 10X Genomics, Inc. | Methods, compositions, and kits for blocking a capture probe on a spatial array |
WO2023118546A2 (en) | 2021-12-23 | 2023-06-29 | Boehringer Ingelheim International Gmbh | METHODS AND MOLECULES FOR RNA INTERFERENCE (RNAi) |
US11541116B1 (en) | 2022-01-07 | 2023-01-03 | Kojin Therapeutics, Inc. | Methods and compositions for inducing ferroptosis in vivo |
KR102583230B1 (ko) * | 2023-03-16 | 2023-09-27 | 재단법인 전남바이오산업진흥원 | 뇌경색 예방 또는 치료용 조성물 |
Family Cites Families (497)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US2007A (en) * | 1841-03-16 | Improvement in the mode of harvesting grain | ||
US2006A (en) * | 1841-03-16 | Clamp for crimping leather | ||
US1529202A (en) | 1924-07-16 | 1925-03-10 | Joseph H Miller | Festooning machine for carrying paper and the like |
GB1529202A (en) | 1976-02-20 | 1978-10-18 | Ciba Geigy Ag | Spectral sensitising dyes |
US5221619A (en) | 1977-11-08 | 1993-06-22 | Genentech, Inc. | Method and means for microbial polypeptide expression |
US5583013A (en) | 1977-11-08 | 1996-12-10 | Genentech, Inc. | Method and means for microbial polypeptide expression |
US4704362A (en) | 1977-11-08 | 1987-11-03 | Genentech, Inc. | Recombinant cloning vehicle microbial polypeptide expression |
JPS55116259A (en) | 1979-03-01 | 1980-09-06 | Fuji Photo Film Co Ltd | Microimmunoassay method |
JPS5745460A (en) | 1980-09-02 | 1982-03-15 | Fuji Photo Film Co Ltd | Inspection sheet for measuring trace component and inspecting method using said sheet |
DE3170135D1 (en) | 1980-09-02 | 1985-05-30 | Fuji Photo Film Co Ltd | Method for immunochemical measurement of trace components |
NL8200523A (nl) | 1982-02-11 | 1983-09-01 | Univ Leiden | Werkwijze voor het in vitro transformeren van planteprotoplasten met plasmide-dna. |
US4849513A (en) | 1983-12-20 | 1989-07-18 | California Institute Of Technology | Deoxyribonucleoside phosphoramidites in which an aliphatic amino group is attached to the sugar ring and their use for the preparation of oligonucleotides containing aliphatic amino groups |
US4828979A (en) | 1984-11-08 | 1989-05-09 | Life Technologies, Inc. | Nucleotide analogs for nucleic acid labeling and detection |
US4683202A (en) | 1985-03-28 | 1987-07-28 | Cetus Corporation | Process for amplifying nucleic acid sequences |
US4683195A (en) | 1986-01-30 | 1987-07-28 | Cetus Corporation | Process for amplifying, detecting, and/or-cloning nucleic acid sequences |
DE3529478A1 (de) | 1985-08-16 | 1987-02-19 | Boehringer Mannheim Gmbh | 7-desaza-2'desoxyguanosin-nukleotide, verfahren zu deren herstellung und deren verwendung zur nukleinsaeure-sequenzierung |
US4682195A (en) | 1985-09-30 | 1987-07-21 | General Electric Company | Insulated gate device with configured emitter contact pad |
US4959463A (en) | 1985-10-15 | 1990-09-25 | Genentech, Inc. | Intermediates |
US4659774A (en) | 1985-11-01 | 1987-04-21 | American Hoechst Corporation | Support for solid-phase oligonucleotide synthesis |
US5011769A (en) | 1985-12-05 | 1991-04-30 | Meiogenics U.S. Limited Partnership | Methods for detecting nucleic acid sequences |
US4876187A (en) | 1985-12-05 | 1989-10-24 | Meiogenics, Inc. | Nucleic acid compositions with scissile linkage useful for detecting nucleic acid sequences |
US4910300A (en) | 1985-12-11 | 1990-03-20 | Chiron Corporation | Method for making nucleic acid probes |
CA1284931C (en) | 1986-03-13 | 1991-06-18 | Henry A. Erlich | Process for detecting specific nucleotide variations and genetic polymorphisms present in nucleic acids |
US5268486A (en) | 1986-04-18 | 1993-12-07 | Carnegie-Mellon Unversity | Method for labeling and detecting materials employing arylsulfonate cyanine dyes |
EP0266032A1 (en) | 1986-08-29 | 1988-05-04 | Beecham Group Plc | Modified fibrinolytic enzyme |
US5202231A (en) | 1987-04-01 | 1993-04-13 | Drmanac Radoje T | Method of sequencing of genomes by hybridization of oligonucleotide probes |
US5525464A (en) | 1987-04-01 | 1996-06-11 | Hyseq, Inc. | Method of sequencing by hybridization of oligonucleotide probes |
US4816571A (en) | 1987-06-04 | 1989-03-28 | Applied Biosystems, Inc. | Chemical capping by phosphitylation during oligonucleotide synthesis |
GB8803000D0 (en) | 1988-02-10 | 1988-03-09 | Ekins Roger Philip | Determination of ambient concentrations of several analytes |
US5824311A (en) | 1987-11-30 | 1998-10-20 | Trustees Of The University Of Pennsylvania | Treatment of tumors with monoclonal antibodies against oncogene antigens |
US4952500A (en) | 1988-02-01 | 1990-08-28 | University Of Georgia Research Foundation, Inc. | Cloning systems for Rhodococcus and related bacteria |
GB8810400D0 (en) | 1988-05-03 | 1988-06-08 | Southern E | Analysing polynucleotide sequences |
US4999290A (en) | 1988-03-31 | 1991-03-12 | The Board Of Regents, The University Of Texas System | Detection of genomic abnormalities with unique aberrant gene transcripts |
US5700637A (en) | 1988-05-03 | 1997-12-23 | Isis Innovation Limited | Apparatus and method for analyzing polynucleotide sequences and method of generating oligonucleotide arrays |
US5602244A (en) | 1988-05-26 | 1997-02-11 | Competitive Technologies, Inc. | Polynucleotide phosphorodithioate compounds |
GB8822228D0 (en) | 1988-09-21 | 1988-10-26 | Southern E M | Support-bound oligonucleotides |
US5708154A (en) | 1989-02-24 | 1998-01-13 | City Of Hope | RNA-DNA hybrid molecules of nucleic acid |
US6867195B1 (en) | 1989-03-21 | 2005-03-15 | Vical Incorporated | Lipid-mediated polynucleotide administration to reduce likelihood of subject's becoming infected |
US5703055A (en) | 1989-03-21 | 1997-12-30 | Wisconsin Alumni Research Foundation | Generation of antibodies through lipid mediated DNA delivery |
US5871928A (en) | 1989-06-07 | 1999-02-16 | Fodor; Stephen P. A. | Methods for nucleic acid analysis |
US5242974A (en) | 1991-11-22 | 1993-09-07 | Affymax Technologies N.V. | Polymer reversal on solid surfaces |
US5424186A (en) | 1989-06-07 | 1995-06-13 | Affymax Technologies N.V. | Very large scale immobilized polymer synthesis |
US5527681A (en) | 1989-06-07 | 1996-06-18 | Affymax Technologies N.V. | Immobilized molecular synthesis of systematically substituted compounds |
US5744101A (en) | 1989-06-07 | 1998-04-28 | Affymax Technologies N.V. | Photolabile nucleoside protecting groups |
US5547839A (en) | 1989-06-07 | 1996-08-20 | Affymax Technologies N.V. | Sequencing of surface immobilized polymers utilizing microflourescence detection |
US6040138A (en) | 1995-09-15 | 2000-03-21 | Affymetrix, Inc. | Expression monitoring by hybridization to high density oligonucleotide arrays |
US5800992A (en) | 1989-06-07 | 1998-09-01 | Fodor; Stephen P.A. | Method of detecting nucleic acids |
US5143854A (en) | 1989-06-07 | 1992-09-01 | Affymax Technologies N.V. | Large scale photolithographic solid phase synthesis of polypeptides and receptor binding screening thereof |
US5302523A (en) | 1989-06-21 | 1994-04-12 | Zeneca Limited | Transformation of plant cells |
DE3924454A1 (de) | 1989-07-24 | 1991-02-07 | Cornelis P Prof Dr Hollenberg | Die anwendung von dna und dna-technologie fuer die konstruktion von netzwerken zur verwendung in der chip-konstruktion und chip-produktion (dna chips) |
US5550318A (en) | 1990-04-17 | 1996-08-27 | Dekalb Genetics Corporation | Methods and compositions for the production of stably transformed, fertile monocot plants and cells thereof |
US7705215B1 (en) | 1990-04-17 | 2010-04-27 | Dekalb Genetics Corporation | Methods and compositions for the production of stably transformed, fertile monocot plants and cells thereof |
US5141813A (en) | 1989-08-28 | 1992-08-25 | Clontech Laboratories, Inc. | Multifunctional controlled pore glass reagent for solid phase oligonucleotide synthesis |
GB8920097D0 (en) | 1989-09-06 | 1989-10-18 | Ici Plc | Amplification processes |
US5545522A (en) | 1989-09-22 | 1996-08-13 | Van Gelder; Russell N. | Process for amplifying a target polynucleotide sequence using a single primer-promoter complex |
US5366860A (en) | 1989-09-29 | 1994-11-22 | Applied Biosystems, Inc. | Spectrally resolvable rhodamine dyes for nucleic acid sequence determination |
US5322783A (en) | 1989-10-17 | 1994-06-21 | Pioneer Hi-Bred International, Inc. | Soybean transformation by microparticle bombardment |
ATE269870T1 (de) | 1989-10-24 | 2004-07-15 | Isis Pharmaceuticals Inc | 2'-modifizierte oligonukleotide |
US5188934A (en) | 1989-11-14 | 1993-02-23 | Applied Biosystems, Inc. | 4,7-dichlorofluorescein dyes as molecular probes |
EP0430881A3 (en) | 1989-11-29 | 1991-10-23 | Ciba-Geigy Ag | Photochromic compounds, process for their preparation and their use |
US5486603A (en) | 1990-01-08 | 1996-01-23 | Gilead Sciences, Inc. | Oligonucleotide having enhanced binding affinity |
US5670633A (en) | 1990-01-11 | 1997-09-23 | Isis Pharmaceuticals, Inc. | Sugar modified oligonucleotides that detect and modulate gene expression |
US5859221A (en) | 1990-01-11 | 1999-01-12 | Isis Pharmaceuticals, Inc. | 2'-modified oligonucleotides |
US5872232A (en) | 1990-01-11 | 1999-02-16 | Isis Pharmaceuticals Inc. | 2'-O-modified oligonucleotides |
US6153737A (en) | 1990-01-11 | 2000-11-28 | Isis Pharmaceuticals, Inc. | Derivatized oligonucleotides having improved uptake and other properties |
US5484956A (en) | 1990-01-22 | 1996-01-16 | Dekalb Genetics Corporation | Fertile transgenic Zea mays plant comprising heterologous DNA encoding Bacillus thuringiensis endotoxin |
US5214136A (en) | 1990-02-20 | 1993-05-25 | Gilead Sciences, Inc. | Anthraquinone-derivatives oligonucleotides |
US5288644A (en) | 1990-04-04 | 1994-02-22 | The Rockefeller University | Instrument and method for the sequencing of genome |
US5470967A (en) | 1990-04-10 | 1995-11-28 | The Dupont Merck Pharmaceutical Company | Oligonucleotide analogs with sulfamate linkages |
GB9009980D0 (en) | 1990-05-03 | 1990-06-27 | Amersham Int Plc | Phosphoramidite derivatives,their preparation and the use thereof in the incorporation of reporter groups on synthetic oligonucleotides |
US5602240A (en) | 1990-07-27 | 1997-02-11 | Ciba Geigy Ag. | Backbone modified oligonucleotide analogs |
CA2088258C (en) | 1990-07-27 | 2004-09-14 | Phillip Dan Cook | Nuclease resistant, pyrimidine modified oligonucleotides that detect and modulate gene expression |
US5623070A (en) | 1990-07-27 | 1997-04-22 | Isis Pharmaceuticals, Inc. | Heteroatomic oligonucleoside linkages |
US5610289A (en) | 1990-07-27 | 1997-03-11 | Isis Pharmaceuticals, Inc. | Backbone modified oligonucleotide analogues |
US5223618A (en) | 1990-08-13 | 1993-06-29 | Isis Pharmaceuticals, Inc. | 4'-desmethyl nucleoside analog compounds |
US5378825A (en) | 1990-07-27 | 1995-01-03 | Isis Pharmaceuticals, Inc. | Backbone modified oligonucleotide analogs |
US5965364A (en) | 1990-10-09 | 1999-10-12 | Benner; Steven Albert | Method for selecting functional deoxyribonucleotide derivatives |
US5432272A (en) | 1990-10-09 | 1995-07-11 | Benner; Steven A. | Method for incorporating into a DNA or RNA oligonucleotide using nucleotides bearing heterocyclic bases |
WO1992007095A1 (en) | 1990-10-15 | 1992-04-30 | Stratagene | Arbitrarily primed polymerase chain reaction method for fingerprinting genomes |
US5384253A (en) | 1990-12-28 | 1995-01-24 | Dekalb Genetics Corporation | Genetic transformation of maize cells by electroporation of cells pretreated with pectin degrading enzymes |
US5672697A (en) | 1991-02-08 | 1997-09-30 | Gilead Sciences, Inc. | Nucleoside 5'-methylene phosphonates |
US6287792B1 (en) | 1991-06-17 | 2001-09-11 | The Regents Of The University Of California | Drug delivery of antisense oligonucleotides and peptides to tissues in vivo and to cells using avidin-biotin technology |
AU662906B2 (en) | 1991-06-26 | 1995-09-21 | F. Hoffmann-La Roche Ag | Methods for detection of carcinoma metastases by nucleic acid amplification |
US6369209B1 (en) * | 1999-05-03 | 2002-04-09 | Isis Pharmaceuticals, Inc. | Oligonucleotides having A-DNA form and B-DNA form conformational geometry |
WO1993004169A1 (en) | 1991-08-20 | 1993-03-04 | Genpharm International, Inc. | Gene targeting in animal cells using isogenic dna constructs |
US5639603A (en) | 1991-09-18 | 1997-06-17 | Affymax Technologies N.V. | Synthesizing and screening molecular diversity |
US5610042A (en) | 1991-10-07 | 1997-03-11 | Ciba-Geigy Corporation | Methods for stable transformation of wheat |
IL103674A0 (en) | 1991-11-19 | 1993-04-04 | Houston Advanced Res Center | Method and apparatus for molecule detection |
US5324633A (en) | 1991-11-22 | 1994-06-28 | Affymax Technologies N.V. | Method and apparatus for measuring binding affinity |
US5384261A (en) | 1991-11-22 | 1995-01-24 | Affymax Technologies N.V. | Very large scale immobilized polymer synthesis using mechanically directed flow paths |
US5412087A (en) | 1992-04-24 | 1995-05-02 | Affymax Technologies N.V. | Spatially-addressable immobilization of oligonucleotides and other biological polymers on surfaces |
US5256555A (en) | 1991-12-20 | 1993-10-26 | Ambion, Inc. | Compositions and methods for increasing the yields of in vitro RNA transcription and other polynucleotide synthetic reactions |
US5700922A (en) | 1991-12-24 | 1997-12-23 | Isis Pharmaceuticals, Inc. | PNA-DNA-PNA chimeric macromolecules |
US5260191A (en) | 1992-01-30 | 1993-11-09 | Agracetus, Inc. | Method for diagnosing tumors |
US5652099A (en) | 1992-02-12 | 1997-07-29 | Conrad; Michael J. | Probes comprising fluorescent nucleosides and uses thereof |
DE69333073T2 (de) | 1992-02-12 | 2004-04-15 | Chromagen, Inc., San Diego | Verwendungen von fluoreszierenden n-nukleosiden und dessen analogen |
DE4204650C1 (es) | 1992-02-15 | 1993-07-08 | Hoffmeister, Helmut, Dr., 4400 Muenster, De | |
EP0675966B1 (en) | 1992-02-19 | 2004-10-06 | The Public Health Research Institute Of The City Of New York, Inc. | Novel oligonucleotide arrays and their use for sorting, isolating, sequencing, and manipulating nucleic acids |
US5262311A (en) | 1992-03-11 | 1993-11-16 | Dana-Farber Cancer Institute, Inc. | Methods to clone polyA mRNA |
ATE231920T1 (de) | 1992-03-11 | 2003-02-15 | Dana Farber Cancer Inst Inc | Methode um mrna zu klonieren |
WO1993020236A1 (en) | 1992-04-03 | 1993-10-14 | Applied Biosystems, Inc. | Probe composition and method |
GB9208545D0 (en) | 1992-04-21 | 1992-06-03 | Gatsby Charitable Foundation T | Virus resistant plants |
US5428148A (en) | 1992-04-24 | 1995-06-27 | Beckman Instruments, Inc. | N4 - acylated cytidinyl compounds useful in oligonucleotide synthesis |
EP1983056A1 (en) | 1992-07-07 | 2008-10-22 | Japan Tobacco Inc. | Method for transforming monocotyledons |
US5702932A (en) | 1992-07-20 | 1997-12-30 | University Of Florida | Microinjection methods to transform arthropods with exogenous DNA |
HUT70467A (en) | 1992-07-27 | 1995-10-30 | Pioneer Hi Bred Int | An improved method of agrobactenium-mediated transformation of cultvred soyhean cells |
US5438131A (en) | 1992-09-16 | 1995-08-01 | Bergstrom; Donald E. | 3-nitropyrrole nucleoside |
US5554501A (en) | 1992-10-29 | 1996-09-10 | Beckman Instruments, Inc. | Biopolymer synthesis using surface activated biaxially oriented polypropylene |
GB9222888D0 (en) | 1992-10-30 | 1992-12-16 | British Tech Group | Tomography |
US5503980A (en) | 1992-11-06 | 1996-04-02 | Trustees Of Boston University | Positional sequencing by hybridization |
US5858988A (en) | 1993-02-24 | 1999-01-12 | Wang; Jui H. | Poly-substituted-phenyl-oligoribo nucleotides having enhanced stability and membrane permeability and methods of use |
US5801005A (en) | 1993-03-17 | 1998-09-01 | University Of Washington | Immune reactivity to HER-2/neu protein for diagnosis of malignancies in which the HER-2/neu oncogene is associated |
US5580726A (en) | 1994-04-29 | 1996-12-03 | Geron Corporation | Method and Kit for enhanced differential display |
US5767259A (en) | 1994-12-27 | 1998-06-16 | Naxcor | Oligonucleotides containing base-free linking groups with photoactivatable side chains |
US5858659A (en) | 1995-11-29 | 1999-01-12 | Affymetrix, Inc. | Polymorphism detection |
US5472672A (en) | 1993-10-22 | 1995-12-05 | The Board Of Trustees Of The Leland Stanford Junior University | Apparatus and method for polymer synthesis using arrays |
US5470710A (en) | 1993-10-22 | 1995-11-28 | University Of Utah | Automated hybridization/imaging device for fluorescent multiplex DNA sequencing |
US6045996A (en) | 1993-10-26 | 2000-04-04 | Affymetrix, Inc. | Hybridization assays on oligonucleotide arrays |
JPH09507121A (ja) | 1993-10-26 | 1997-07-22 | アフィマックス テクノロジーズ ナームロゼ ベノートスハップ | 生物学的チップ上の核酸プローブアレー |
US5429807A (en) | 1993-10-28 | 1995-07-04 | Beckman Instruments, Inc. | Method and apparatus for creating biopolymer arrays on a solid support surface |
US5925517A (en) | 1993-11-12 | 1999-07-20 | The Public Health Research Institute Of The City Of New York, Inc. | Detectably labeled dual conformation oligonucleotide probes, assays and kits |
US5538848A (en) | 1994-11-16 | 1996-07-23 | Applied Biosystems Division, Perkin-Elmer Corp. | Method for detecting nucleic acid amplification using self-quenching fluorescence probe |
WO1995014106A2 (en) | 1993-11-17 | 1995-05-26 | Id Biomedical Corporation | Cycling probe cleavage detection of nucleic acid sequences |
US5610287A (en) | 1993-12-06 | 1997-03-11 | Molecular Tool, Inc. | Method for immobilizing nucleic acid molecules |
US5446137B1 (en) | 1993-12-09 | 1998-10-06 | Behringwerke Ag | Oligonucleotides containing 4'-substituted nucleotides |
US5519134A (en) | 1994-01-11 | 1996-05-21 | Isis Pharmaceuticals, Inc. | Pyrrolidine-containing monomers and oligomers |
GB9401833D0 (en) | 1994-02-01 | 1994-03-30 | Isis Innovation | Method for discovering ligands |
EP0743989B1 (en) | 1994-02-14 | 2007-03-21 | Smithkline Beecham Corporation | Methed of identifying differentially expressed genes |
DE4406524A1 (de) | 1994-02-28 | 1995-08-31 | Boehringer Mannheim Gmbh | 3'-RNA-Markierung mit Terminaler Transferase |
US5844107A (en) | 1994-03-23 | 1998-12-01 | Case Western Reserve University | Compacted nucleic acids and their delivery to cells |
DE69535853D1 (de) | 1994-03-23 | 2008-11-20 | Univ Case Western Reserve | Kompaktnukleinsäure und ihre verabreichung in zellen |
US5972901A (en) | 1994-03-23 | 1999-10-26 | Case Western Reserve University | Serpin enzyme complex receptor--mediated gene transfer |
US6077835A (en) | 1994-03-23 | 2000-06-20 | Case Western Reserve University | Delivery of compacted nucleic acid to cells |
US5571639A (en) | 1994-05-24 | 1996-11-05 | Affymax Technologies N.V. | Computer-aided engineering system for design of sequence arrays and lithographic masks |
US5807522A (en) | 1994-06-17 | 1998-09-15 | The Board Of Trustees Of The Leland Stanford Junior University | Methods for fabricating microarrays of biological samples |
US5656610A (en) | 1994-06-21 | 1997-08-12 | University Of Southern California | Producing a protein in a mammal by injection of a DNA-sequence into the tongue |
US6146886A (en) | 1994-08-19 | 2000-11-14 | Ribozyme Pharmaceuticals, Inc. | RNA polymerase III-based expression of therapeutic RNAs |
GB9506466D0 (en) | 1994-08-26 | 1995-05-17 | Prolifix Ltd | Cell cycle regulated repressor and dna element |
US5574146A (en) | 1994-08-30 | 1996-11-12 | Beckman Instruments, Inc. | Oligonucleotide synthesis with substituted aryl carboxylic acids as activators |
US5554744A (en) | 1994-09-23 | 1996-09-10 | Hybridon, Inc. | Method for loading solid supports for nucleic acid synthesis |
US6096314A (en) | 1994-10-07 | 2000-08-01 | Yeda Research And Development Co. Ltd. | Peptides and pharmaceutical compositions comprising them |
US5604097A (en) | 1994-10-13 | 1997-02-18 | Spectragen, Inc. | Methods for sorting polynucleotides using oligonucleotide tags |
US5556752A (en) | 1994-10-24 | 1996-09-17 | Affymetrix, Inc. | Surface-bound, unimolecular, double-stranded DNA |
US5736524A (en) | 1994-11-14 | 1998-04-07 | Merck & Co.,. Inc. | Polynucleotide tuberculosis vaccine |
US5830645A (en) | 1994-12-09 | 1998-11-03 | The Regents Of The University Of California | Comparative fluorescence hybridization to nucleic acid arrays |
US5599695A (en) | 1995-02-27 | 1997-02-04 | Affymetrix, Inc. | Printing molecular library arrays using deprotection agents solely in the vapor phase |
ATE270712T1 (de) | 1995-03-17 | 2004-07-15 | Wayne John Cancer Inst | Nachweis von melanomenmetastasen unter verwendung eines mehrfachmarker-tests |
US5801155A (en) | 1995-04-03 | 1998-09-01 | Epoch Pharmaceuticals, Inc. | Covalently linked oligonucleotide minor grove binder conjugates |
GB9507238D0 (en) | 1995-04-07 | 1995-05-31 | Isis Innovation | Detecting dna sequence variations |
US5624711A (en) | 1995-04-27 | 1997-04-29 | Affymax Technologies, N.V. | Derivatization of solid supports and methods for oligomer synthesis |
DE19518505A1 (de) | 1995-05-19 | 1996-11-21 | Max Planck Gesellschaft | Verfahren zur Genexpressionsanalyse |
EP0832271B8 (en) | 1995-06-07 | 2005-03-02 | INEX Pharmaceuticals Corp. | Lipid-nucleic acid particles prepared via a hydrophobic lipid-nucleic acid complex intermediate and use for gene transfer |
US5545531A (en) | 1995-06-07 | 1996-08-13 | Affymax Technologies N.V. | Methods for making a device for concurrently processing multiple biological chip assays |
US6111095A (en) | 1995-06-07 | 2000-08-29 | Merck & Co., Inc. | Capped synthetic RNA, analogs, and aptamers |
US5981501A (en) | 1995-06-07 | 1999-11-09 | Inex Pharmaceuticals Corp. | Methods for encapsulating plasmids in lipid bilayers |
US6998268B2 (en) | 1995-07-03 | 2006-02-14 | Dainippon Sumitomo Pharma Co. Ltd. | Gene preparations |
US5637683A (en) | 1995-07-13 | 1997-06-10 | Cornell Research Foundation, Inc. | Nucleic acid analog with amide linkage and method of making that analog |
US5661028A (en) | 1995-09-29 | 1997-08-26 | Lockheed Martin Energy Systems, Inc. | Large scale DNA microsequencing device |
US5658734A (en) | 1995-10-17 | 1997-08-19 | International Business Machines Corporation | Process for synthesizing chemical compounds |
US5705629A (en) | 1995-10-20 | 1998-01-06 | Hybridon, Inc. | Methods for H-phosphonate synthesis of mono- and oligonucleotides |
US6418382B2 (en) | 1995-10-24 | 2002-07-09 | Curagen Corporation | Method and apparatus for identifying, classifying, or quantifying DNA sequences in a sample without sequencing |
US5871697A (en) | 1995-10-24 | 1999-02-16 | Curagen Corporation | Method and apparatus for identifying, classifying, or quantifying DNA sequences in a sample without sequencing |
US20040142895A1 (en) | 1995-10-26 | 2004-07-22 | Sirna Therapeutics, Inc. | Nucleic acid-based modulation of gene expression in the vascular endothelial growth factor pathway |
US5780448A (en) | 1995-11-07 | 1998-07-14 | Ottawa Civic Hospital Loeb Research | DNA-based vaccination of fish |
US5998203A (en) * | 1996-04-16 | 1999-12-07 | Ribozyme Pharmaceuticals, Inc. | Enzymatic nucleic acids containing 5'-and/or 3'-cap structures |
EP0880598A4 (en) | 1996-01-23 | 2005-02-23 | Affymetrix Inc | RAPID EVALUATION OF NUCLEIC ACID ABUNDANCE DIFFERENCE, WITH A HIGH-DENSITY OLIGONUCLEOTIDE SYSTEM |
AU2253397A (en) | 1996-01-23 | 1997-08-20 | Affymetrix, Inc. | Nucleic acid analysis techniques |
US5837196A (en) | 1996-01-26 | 1998-11-17 | The Regents Of The University Of California | High density array fabrication and readout method for a fiber optic biosensor |
US5670663A (en) | 1996-02-14 | 1997-09-23 | Regents Of The University Of California | Recovery of taxanes from conifers |
US6020481A (en) | 1996-04-01 | 2000-02-01 | The Perkin-Elmer Corporation | Asymmetric benzoxanthene dyes |
US6458530B1 (en) | 1996-04-04 | 2002-10-01 | Affymetrix Inc. | Selecting tag nucleic acids |
CA2252048C (en) | 1996-04-12 | 2008-03-11 | The Public Health Research Institute Of The City Of New York, Inc. | Detection probes, kits and assays |
US5800996A (en) | 1996-05-03 | 1998-09-01 | The Perkin Elmer Corporation | Energy transfer dyes with enchanced fluorescence |
US5847162A (en) | 1996-06-27 | 1998-12-08 | The Perkin Elmer Corporation | 4, 7-Dichlororhodamine dyes |
US5863727A (en) | 1996-05-03 | 1999-01-26 | The Perkin-Elmer Corporation | Energy transfer dyes with enhanced fluorescence |
US5945526A (en) | 1996-05-03 | 1999-08-31 | Perkin-Elmer Corporation | Energy transfer dyes with enhanced fluorescence |
US6184037B1 (en) | 1996-05-17 | 2001-02-06 | Genemedicine, Inc. | Chitosan related compositions and methods for delivery of nucleic acids and oligonucleotides into a cell |
SE506700C2 (sv) | 1996-05-31 | 1998-02-02 | Mikael Kubista | Sond och förfaranden för analys av nukleinsyra |
US5739169A (en) | 1996-05-31 | 1998-04-14 | Procept, Incorporated | Aromatic compounds for inhibiting immune response |
ES2243393T3 (es) | 1996-06-04 | 2005-12-01 | University Of Utah Research Foundation | Monitorizacion de la hibridacion durante la pcr. |
US5898031A (en) | 1996-06-06 | 1999-04-27 | Isis Pharmaceuticals, Inc. | Oligoribonucleotides for cleaving RNA |
US5945100A (en) | 1996-07-31 | 1999-08-31 | Fbp Corporation | Tumor delivery vehicles |
US6770291B2 (en) | 1996-08-30 | 2004-08-03 | The United States Of America As Represented By The Department Of Health And Human Services | Liposome complexes for increased systemic delivery |
GB9618050D0 (en) | 1996-08-29 | 1996-10-09 | Cancer Res Campaign Tech | Global amplification of nucleic acids |
US5981274A (en) | 1996-09-18 | 1999-11-09 | Tyrrell; D. Lorne J. | Recombinant hepatitis virus vectors |
US5886165A (en) | 1996-09-24 | 1999-03-23 | Hybridon, Inc. | Mixed backbone antisense oligonucleotides containing 2'-5'-ribonucleotide- and 3'-5'-deoxyribonucleotides segments |
DE69841038D1 (es) | 1997-03-07 | 2009-09-17 | Siemens Healthcare Diagnostics | |
CA2254785A1 (en) | 1997-03-10 | 1998-09-17 | Japan Tobacco Inc. | Antisense base sequences |
US6251666B1 (en) | 1997-03-31 | 2001-06-26 | Ribozyme Pharmaceuticals, Inc. | Nucleic acid catalysts comprising L-nucleotide analogs |
US6090556A (en) | 1997-04-07 | 2000-07-18 | Japan Science & Technology Corporation | Method for quantitatively determining the expression of a gene |
NO972006D0 (no) | 1997-04-30 | 1997-04-30 | Forskningsparken I Aas As | Ny metode for diagnose av sykdommer |
JP4656675B2 (ja) | 1997-05-14 | 2011-03-23 | ユニバーシティー オブ ブリティッシュ コロンビア | 脂質小胞への荷電した治療剤の高率封入 |
US6262252B1 (en) | 1997-05-19 | 2001-07-17 | Mirus, Inc. | Single-step method for labeling nucleic acids with mustard or aziridine labeling reagents |
US5919626A (en) | 1997-06-06 | 1999-07-06 | Orchid Bio Computer, Inc. | Attachment of unmodified nucleic acids to silanized solid phase surfaces |
WO1998056954A1 (en) | 1997-06-13 | 1998-12-17 | Affymetrix, Inc. | Method to detect gene polymorphisms and monitor allelic expression employing a probe array |
US6008379A (en) | 1997-10-01 | 1999-12-28 | The Perkin-Elmer Corporation | Aromatic-substituted xanthene dyes |
US5994624A (en) | 1997-10-20 | 1999-11-30 | Cotton Incorporated | In planta method for the production of transgenic plants |
WO1999022018A2 (en) | 1997-10-27 | 1999-05-06 | Boston Probes, Inc. | Methods, kits and compositions pertaining to pna molecular beacons |
US6485901B1 (en) | 1997-10-27 | 2002-11-26 | Boston Probes, Inc. | Methods, kits and compositions pertaining to linear beacons |
DK1032705T3 (da) | 1997-10-30 | 2012-03-26 | Cold Spring Harbor Lab | Probearrays og fremgangsmåder til at benytte probearrays til at skelne mellem DNA |
US5936087A (en) | 1997-11-25 | 1999-08-10 | The Perkin-Elmer Corporation | Dibenzorhodamine dyes |
US6238869B1 (en) | 1997-12-19 | 2001-05-29 | High Throughput Genomics, Inc. | High throughput assay system |
US6232066B1 (en) | 1997-12-19 | 2001-05-15 | Neogen, Inc. | High throughput assay system |
US6458533B1 (en) | 1997-12-19 | 2002-10-01 | High Throughput Genomics, Inc. | High throughput assay system for monitoring ESTs |
US6506559B1 (en) | 1997-12-23 | 2003-01-14 | Carnegie Institute Of Washington | Genetic inhibition by double-stranded RNA |
US6121058A (en) | 1998-01-02 | 2000-09-19 | Intel Corporation | Method for removing accumulated solder from probe card probing features |
US6087102A (en) | 1998-01-07 | 2000-07-11 | Clontech Laboratories, Inc. | Polymeric arrays and methods for their use in binding assays |
US6269846B1 (en) | 1998-01-13 | 2001-08-07 | Genetic Microsystems, Inc. | Depositing fluid specimens on substrates, resulting ordered arrays, techniques for deposition of arrays |
US5942398A (en) | 1998-02-26 | 1999-08-24 | Millennium Pharmaceuticals, Inc. | Nucleic acid molecules encoding glutx and uses thereof |
AUPP249298A0 (en) | 1998-03-20 | 1998-04-23 | Ag-Gene Australia Limited | Synthetic genes and genetic constructs comprising same I |
US6004755A (en) | 1998-04-07 | 1999-12-21 | Incyte Pharmaceuticals, Inc. | Quantitative microarray hybridizaton assays |
WO1999054459A2 (en) | 1998-04-20 | 1999-10-28 | Ribozyme Pharmaceuticals, Inc. | Nucleic acid molecules with novel chemical compositions capable of modulating gene expression |
US6037129A (en) | 1998-05-28 | 2000-03-14 | Medical University Of South Carolina | Multi-marker RT-PCR panel for detecting metastatic breast cancer |
FR2780059B1 (fr) | 1998-06-17 | 2002-10-11 | Bio Merieux | Procede de marquage d'un acide ribonucleique et fragments d'arn marques ainsi obtenus |
US6576420B1 (en) | 1998-06-23 | 2003-06-10 | Regents Of The University Of California | Method for early diagnosis of, and determination of prognosis in, cancer |
GB9815799D0 (en) | 1998-07-21 | 1998-09-16 | Pharmagene Lab Limited | Quantitative analysis of gene expression |
US6730477B1 (en) | 1998-08-04 | 2004-05-04 | Diadexus, Inc. | Method of diagnosing, monitoring and staging breast cancer |
US6140054A (en) | 1998-09-30 | 2000-10-31 | University Of Utah Research Foundation | Multiplex genotyping using fluorescent hybridization probes |
AU2144000A (en) | 1998-10-27 | 2000-05-15 | Affymetrix, Inc. | Complexity management and analysis of genomic dna |
DE19956568A1 (de) | 1999-01-30 | 2000-08-17 | Roland Kreutzer | Verfahren und Medikament zur Hemmung der Expression eines vorgegebenen Gens |
GB9904991D0 (en) | 1999-03-05 | 1999-04-28 | Univ Nottingham | Genetic screening |
EP1161439B1 (en) | 1999-03-18 | 2010-04-21 | Exiqon A/S | Xylo-lna analogues |
US6383752B1 (en) | 1999-03-31 | 2002-05-07 | Hybridon, Inc. | Pseudo-cyclic oligonucleobases |
US6103576A (en) * | 1999-04-13 | 2000-08-15 | Microchip Technology Incorporated | Dielectric layer of a memory cell having a stacked oxide sidewall and method of fabricating same |
NZ514348A (en) | 1999-05-04 | 2004-05-28 | Exiqon As | L-ribo-LNA analogues |
US6638717B2 (en) | 1999-05-19 | 2003-10-28 | Aventis Pharmaceuticals, Inc. | Microarray-based subtractive hybridzation |
DE60030970T2 (de) | 1999-05-24 | 2007-09-06 | Introgen Therapeutics Inc., Austin | Verfahren und zusammensetzungen für nichtvirale gentherapie zur behandlung von hyperproliferativen krankheiten |
US6132997A (en) | 1999-05-28 | 2000-10-17 | Agilent Technologies | Method for linear mRNA amplification |
EP1206234A4 (en) | 1999-06-03 | 2005-06-01 | Jessie L S Au | METHODS AND COMPOSITIONS FOR MODULATING PROLIFERATION AND CELL DEATH |
WO2000075356A1 (en) | 1999-06-04 | 2000-12-14 | Lin Shi Lung | Rna polymerase chain reaction |
US6964847B1 (en) | 1999-07-14 | 2005-11-15 | Packard Biosciences Company | Derivative nucleic acids and uses thereof |
US6201112B1 (en) | 1999-07-22 | 2001-03-13 | Agilent Technologies Inc. | Method for 3′ end-labeling ribonucleic acids |
US7005261B1 (en) | 1999-07-29 | 2006-02-28 | British Biocell International Limited | Method for detecting nucleic acid target sequences involving in vitro transcription from an RNA polymerase promoter |
US6140500A (en) | 1999-09-03 | 2000-10-31 | Pe Corporation | Red-emitting [8,9]benzophenoxazine nucleic acid dyes and methods for their use |
US6511832B1 (en) | 1999-10-06 | 2003-01-28 | Texas A&M University System | In vitro synthesis of capped and polyadenylated mRNAs using baculovirus RNA polymerase |
US20020094546A1 (en) | 1999-10-07 | 2002-07-18 | Shimkets Richard A. | Growth factor polypeptides and nucleic acids encoding same |
WO2001029058A1 (en) | 1999-10-15 | 2001-04-26 | University Of Massachusetts | Rna interference pathway genes as tools for targeted genetic interference |
US6528254B1 (en) | 1999-10-29 | 2003-03-04 | Stratagene | Methods for detection of a target nucleic acid sequence |
US6191278B1 (en) | 1999-11-03 | 2001-02-20 | Pe Corporation | Water-soluble rhodamine dyes and conjugates thereof |
US6458382B1 (en) | 1999-11-12 | 2002-10-01 | Mirus Corporation | Nucleic acid transfer complexes |
US6435245B1 (en) | 1999-11-18 | 2002-08-20 | Pitney Bowes Inc. | System for folding and tabbing sheets |
GB9927444D0 (en) | 1999-11-19 | 2000-01-19 | Cancer Res Campaign Tech | Inhibiting gene expression |
DE10160151A1 (de) | 2001-01-09 | 2003-06-26 | Ribopharma Ag | Verfahren zur Hemmung der Expression eines vorgegebenen Zielgens |
DE10100586C1 (de) | 2001-01-09 | 2002-04-11 | Ribopharma Ag | Verfahren zur Hemmung der Expression eines Ziegens |
WO2001038580A2 (en) | 1999-11-26 | 2001-05-31 | Curagen Corporation | Nucleic acid probe arrays |
US6383749B2 (en) | 1999-12-02 | 2002-05-07 | Clontech Laboratories, Inc. | Methods of labeling nucleic acids for use in array based hybridization assays |
US7205105B2 (en) | 1999-12-08 | 2007-04-17 | Epoch Biosciences, Inc. | Real-time linear detection probes: sensitive 5′-minor groove binder-containing probes for PCR analysis |
EP1257664A4 (en) | 2000-01-28 | 2006-04-05 | Althea Technologies Inc | METHOD FOR THE ANALYSIS OF GENE EXPRESSION |
WO2002081628A2 (en) | 2001-04-05 | 2002-10-17 | Ribozyme Pharmaceuticals, Incorporated | Modulation of gene expression associated with inflammation proliferation and neurite outgrowth, using nucleic acid based technologies |
US8202979B2 (en) | 2002-02-20 | 2012-06-19 | Sirna Therapeutics, Inc. | RNA interference mediated inhibition of gene expression using chemically modified short interfering nucleic acid |
US20020065406A1 (en) | 2000-03-24 | 2002-05-30 | Meyers Rachel A. | 18221, a novel dual specificity phosphatase and uses thereof |
US6447723B1 (en) | 2000-03-13 | 2002-09-10 | Packard Instrument Company, Inc. | Microarray spotting instruments incorporating sensors and methods of using sensors for improving performance of microarray spotting instruments |
US20030084471A1 (en) | 2000-03-16 | 2003-05-01 | David Beach | Methods and compositions for RNA interference |
AU2001250932A1 (en) | 2000-03-23 | 2001-10-03 | Diadexus, Inc. | Compositions and methods of diagnosing, monitoring, staging, imaging and treating prostate cancer |
WO2001072780A2 (en) | 2000-03-27 | 2001-10-04 | Diadexus, Inc. | Polynucleotides for diagnosing mammary gland cancer |
WO2001073030A2 (en) | 2000-03-28 | 2001-10-04 | Diadexus, Inc. | Compositions and methods of diagnosing, monitoring, staging, imaging and treating colon cancer |
WO2001072775A2 (en) | 2000-03-29 | 2001-10-04 | Diadexus, Inc. | Polynucleotides and polypeptides as well as methods for diagnosing and treating lung cancer |
KR20080023768A (ko) | 2000-03-30 | 2008-03-14 | 화이트헤드 인스티튜트 포 바이오메디칼 리서치 | Rna 간섭의 rna 서열 특이적인 매개체 |
AU2001251223A1 (en) | 2000-03-30 | 2001-10-15 | Diadexus, Inc. | Compositions and methods for diagnosing, monitoring, staging, imaging and treating stomach cancer |
US6573048B1 (en) | 2000-04-18 | 2003-06-03 | Naxcor | Degradable nucleic acid probes and nucleic acid detection methods |
WO2001086307A2 (en) | 2000-05-10 | 2001-11-15 | Sirbasku David A | Compositions and methods for the diagnosis, treatment and prevention of steroid hormone responsive cancers |
US20020042388A1 (en) | 2001-05-01 | 2002-04-11 | Cooper Mark J. | Lyophilizable and enhanced compacted nucleic acids |
EP2279757A3 (en) | 2000-06-02 | 2011-08-03 | Bracco Suisse SA | Compounds for targeting endothelial cells |
CA2414396A1 (en) | 2000-06-26 | 2002-01-03 | The United States Of America, As Represented By The Secretary Of Agricul Ture | Production of vaccines using transgenic plants |
EP1294947A2 (en) | 2000-06-30 | 2003-03-26 | Epigenomics AG | Method and nucleic acids for pharmacogenomic methylation analysis |
US6596490B2 (en) | 2000-07-14 | 2003-07-22 | Applied Gene Technologies, Inc. | Nucleic acid hairpin probes and uses thereof |
JP4180365B2 (ja) | 2000-07-31 | 2008-11-12 | エフ.ホフマン−ラ ロシュ アーゲー | ピペラジン誘導体 |
WO2002012563A2 (en) | 2000-08-04 | 2002-02-14 | Board Of Regents, The University Of Texas System | Detection and diagnosis of smoking related cancers |
JP2002067789A (ja) * | 2000-09-05 | 2002-03-08 | Yazaki Corp | ランプユニットの電線接続構造 |
AU2001292842A1 (en) | 2000-09-19 | 2002-04-02 | Diadexus, Inc. | Compositions and methods relating to prostate specific genes and proteins |
US20030082604A1 (en) | 2000-09-27 | 2003-05-01 | Swanson Melvin J. | High density arrays |
US6617112B2 (en) | 2000-10-11 | 2003-09-09 | Monsanto Technology Llc | Methods for gene array analysis of nuclear runoff transcripts |
US6350580B1 (en) | 2000-10-11 | 2002-02-26 | Stratagene | Methods for detection of a target nucleic acid using a probe comprising secondary structure |
US7162371B1 (en) | 2000-10-11 | 2007-01-09 | Georgia Tech Research Corporation | Differentially-expressed conifer cDNAs, and their use in improving somatic embryogenesis |
WO2002032396A2 (en) | 2000-10-16 | 2002-04-25 | Massachusetts Institute Of Technology | Lipid-protein-sugar particles for delivery of nucleic acids |
WO2002048168A1 (en) * | 2000-10-24 | 2002-06-20 | Isis Pharmaceuticals, Inc. | Antisense modulation of tnfr1 expression |
US7001724B1 (en) | 2000-11-28 | 2006-02-21 | Applera Corporation | Compositions, methods, and kits for isolating nucleic acids using surfactants and proteases |
GB0029360D0 (en) | 2000-12-01 | 2001-01-17 | Univ Nottingham | Humanised antibodies and uses thereof |
KR100872437B1 (ko) | 2000-12-01 | 2008-12-05 | 막스-플랑크-게젤샤프트 츄어 푀르더룽 데어 비쎈샤프텐 에.파우. | Rna 간섭을 매개하는 작은 rna 분자 |
AU2002219707A1 (en) | 2000-12-04 | 2002-06-18 | Primagen B.V. | Testing endosymbiont cellular organelles and compounds identifiable therewith |
US20030099976A1 (en) | 2001-01-17 | 2003-05-29 | Tai-Jay Chang | Androgen receptor complex-associated protein |
WO2002057496A2 (en) | 2001-01-18 | 2002-07-25 | Socratech L.L.C. | Gene expression profiling of endothelium in alzheimer's disease |
US7015047B2 (en) | 2001-01-26 | 2006-03-21 | Aviva Biosciences Corporation | Microdevices having a preferential axis of magnetization and uses thereof |
US20040058373A1 (en) | 2001-01-31 | 2004-03-25 | Winkler Matthew M. | Competitive amplification of fractionated targets from multiple nucleic acid samples |
US20040110191A1 (en) | 2001-01-31 | 2004-06-10 | Winkler Matthew M. | Comparative analysis of nucleic acids using population tagging |
WO2002064835A2 (en) | 2001-01-31 | 2002-08-22 | Ambion, Inc. | Methods for nucleic acid fingerprint analysis |
WO2002073504A1 (en) | 2001-03-14 | 2002-09-19 | Gene Logic, Inc. | A system and method for retrieving and using gene expression data from multiple sources |
US20030170623A1 (en) | 2001-04-13 | 2003-09-11 | Jingwen Chen | Multiplexed gene analysis on a mobile solid support |
AU2002307438A1 (en) | 2001-04-20 | 2002-11-05 | Ludwig Institute For Cancer Research | Cancer-testis antigens |
WO2002087507A2 (en) | 2001-04-27 | 2002-11-07 | Sunnybrook & Women's College Health Sciences Centre | Breast cancer-associated genes and uses thereof |
CA2445947A1 (en) | 2001-04-30 | 2002-11-07 | Targeted Genetics Corporation | Lipid-comprising drug delivery complexes and methods for their production |
AUPR480901A0 (en) | 2001-05-04 | 2001-05-31 | Genomics Research Partners Pty Ltd | Diagnostic method for assessing a condition of a performance animal |
US20040209832A1 (en) | 2001-11-30 | 2004-10-21 | Mcswiggen James | RNA interference mediated inhibition of vascular endothelial growth factor and vascular endothelial growth factor receptor gene expression using short interfering nucleic acid (siNA) |
WO2003070917A2 (en) * | 2002-02-20 | 2003-08-28 | Sirna Therapeutics, Inc. | Rna interference mediated inhibition of myc and myb genes or genes of their respective pathways |
US20040243362A1 (en) | 2001-06-01 | 2004-12-02 | Liebman Michael N. | Information processing method for disease stratification and assessment of disease progressing |
US7171311B2 (en) | 2001-06-18 | 2007-01-30 | Rosetta Inpharmatics Llc | Methods of assigning treatment to breast cancer patients |
US20040086504A1 (en) | 2001-06-21 | 2004-05-06 | Deepak Sampath | Cyr61 as a target for treatment and diagnosis of breast cancer |
AU2002315413A1 (en) | 2001-06-22 | 2003-01-08 | Gene Logic, Inc. | Platform for management and mining of genomic data |
AU2002346008A1 (en) | 2001-06-28 | 2003-03-03 | Dermtech International | Method for detection of melanoma |
IL159627A0 (en) | 2001-06-29 | 2004-06-01 | Univ Leland Stanford Junior | T-cell regulatory genes and diagnostic methods utilizing the same |
US20030143571A1 (en) | 2001-08-08 | 2003-07-31 | North Carolina State University | Infectious disease microarray |
AU2002331777A1 (en) | 2001-08-30 | 2003-03-18 | Spectral Genomics, Inc. | Arrays comprising pre-labeled biological molecules and methods for making and using these arrays |
US20030198627A1 (en) * | 2001-09-01 | 2003-10-23 | Gert-Jan Arts | siRNA knockout assay method and constructs |
US7078180B2 (en) | 2001-09-05 | 2006-07-18 | The Children's Hospital Of Philadelphia | Methods and compositions useful for diagnosis, staging, and treatment of cancers and tumors |
CA2459731A1 (en) | 2001-09-06 | 2003-03-20 | Merck Patent Gesellschaft Mit Beschraenkter Haftung | Genetic analysis of biological samples in arrayed expanded representations of their nucleic acids |
EP1425090A2 (en) | 2001-09-07 | 2004-06-09 | Corning Incorporated | MICROCOLUMN−PLATFORM BASED ARRAY FOR HIGH−THROUGHPUT ANALYSIS |
DK1436404T3 (da) | 2001-09-19 | 2010-03-08 | Alexion Pharma Inc | Manipulerede templates og deres anvendelse i single-primer amplifikation |
AU2002305767B2 (en) | 2001-09-20 | 2008-04-10 | Cornell Research Foundation, Inc. | Methods and compositions for treating and preventing skin disorders using binding agents specific for PSMA |
US6593091B2 (en) | 2001-09-24 | 2003-07-15 | Beckman Coulter, Inc. | Oligonucleotide probes for detecting nucleic acids through changes in flourescence resonance energy transfer |
AU2002347035B2 (en) * | 2001-09-28 | 2008-04-03 | Max-Planck-Gesellschaft Zur Forderung Der Wissenschaften E.V | Micro-RNA molecules |
WO2003029485A2 (en) | 2001-10-02 | 2003-04-10 | Azign Bioscience A/S | Specific differential display arrays |
AU2002367886B8 (en) | 2001-10-12 | 2008-08-14 | Perkinelmer Las, Inc. | Compilations of nucleic acids and arrays and methods of using them |
AU2002368202B2 (en) | 2001-11-02 | 2008-06-05 | Insert Therapeutics, Inc | Methods and compositions for therapeutic use of RNA interference |
US20030087298A1 (en) | 2001-11-02 | 2003-05-08 | Roland Green | Detection of hybridization on oligonucleotide microarray through covalently labeling microarray probe |
US20040063654A1 (en) | 2001-11-02 | 2004-04-01 | Davis Mark E. | Methods and compositions for therapeutic use of RNA interference |
WO2003043487A2 (en) | 2001-11-19 | 2003-05-30 | Protometrix, Inc. | Method of using a non-antibody protein to detect and measure an analyte |
AU2002357368A1 (en) | 2001-12-19 | 2003-07-09 | Affymetrix, Inc. | Array plates and method for constructing array plates |
EP1465997A4 (en) | 2001-12-27 | 2006-05-24 | Agy Therapeutics Inc | USE OF BIOMOLECULAR OBJECTIVES IN THE TREATMENT AND VISUALIZATION OF TUMORS |
US7141372B2 (en) | 2002-01-18 | 2006-11-28 | Health Research Incorporated | Universal RT-coupled PCR method for the specific amplification of mRNA |
EP1470255A2 (en) | 2002-01-30 | 2004-10-27 | Epigenomics AG | Identification of cell differentiation states based on methylation patterns |
US20030148362A1 (en) | 2002-02-07 | 2003-08-07 | Eastern Virginia Medical School Of The Medical College Of Hampton Roads | Diagnostic microarray and method of use thereof |
US20030232356A1 (en) | 2002-02-08 | 2003-12-18 | Dooley Thomas P. | Skin cell biomarkers and methods for identifying biomarkers using nucleic acid microarrays |
CA2478605A1 (en) | 2002-03-07 | 2003-09-18 | University Of Utah Research Foundation | Methods for identifying large subsets of differentially expressed genes based on multivariate microarray data analysis |
US20070025997A1 (en) | 2002-04-03 | 2007-02-01 | Usha Nagavarapu | Use of biomolecular targets in the treatment and visualization of brain tumors |
WO2003085125A1 (en) | 2002-04-03 | 2003-10-16 | Agy Therapeutics, Inc. | Use of biomolecular targets in the treatment and visualization of brain tumors |
DK1504126T3 (da) | 2002-05-03 | 2014-06-10 | Univ Duke | Fremgangsmåde til regulering af genekspression |
DE60323625D1 (de) | 2002-05-03 | 2008-10-30 | Vialogy Llc | Verfahren zur charakterisierung der ausgangssignale eines microarrays |
AU2003285852B2 (en) | 2002-05-20 | 2006-12-14 | Northrop Grumman Corporation | Point source biological agent detection system |
AU2003241607B2 (en) | 2002-05-24 | 2007-09-06 | Nimblegen Systems, Inc. | Microarrays and method for running hybridization reaction for multiple samples on a single microarray |
AUPS261402A0 (en) | 2002-05-28 | 2002-06-20 | Compusign Pty Ltd | Array monitoring |
US20030228579A1 (en) | 2002-06-05 | 2003-12-11 | Uri Alon | Ordering genes by analysis of expression kinetics |
ATE350473T2 (de) | 2002-08-05 | 2007-01-15 | Atugen Ag | Weitere neue formen von interferierende rns moleküle |
WO2004014933A1 (en) * | 2002-08-07 | 2004-02-19 | University Of Massachusetts | Compositions for rna interference and methods of use thereof |
US20040029121A1 (en) | 2002-08-08 | 2004-02-12 | Susan Cottrell | Methods and nucleic acids for the analysis of CpG dinucleotide methylation status associated with the calcitonin gene |
US20040029128A1 (en) | 2002-08-08 | 2004-02-12 | Epigenomics, Inc. | Methods and nucleic acids for the analysis of CpG dinucleotide methylation status associated with the calcitonin gene |
EP1560924A4 (en) | 2002-08-16 | 2006-05-31 | Wayne John Cancer Inst | MOLECULAR LYMPHATIC MAPPING OF VIRCHOV LYMPHOTIC NODES |
AU2003270654A1 (en) | 2002-09-12 | 2004-04-30 | Baylor College Of Medecine | System and method for image segmentation |
AU2003267583A1 (en) | 2002-09-19 | 2004-04-08 | The Chancellor, Master And Scholars Of The University Of Oxford | Molecular arrays and single molecule detection |
WO2004029212A2 (en) | 2002-09-25 | 2004-04-08 | University Of Massachusetts | In vivo gene silencing by chemically modified and stable sirna |
AU2003291287A1 (en) | 2002-11-01 | 2004-06-07 | John Fonda Crary | Apkc isoforms in nervous system disorders and cancer |
EP1418241A1 (en) | 2002-11-08 | 2004-05-12 | PrimaGen Holding B.V. | Method for quantifying a ratio between at least two nucleic acid sequences |
CA2504605C (en) | 2002-11-13 | 2016-01-19 | Thomas Jefferson University | Treatment of chronic lymphocytic leukemia and prostate cancer with microrna mir15 |
US7250496B2 (en) * | 2002-11-14 | 2007-07-31 | Rosetta Genomics Ltd. | Bioinformatically detectable group of novel regulatory genes and uses thereof |
US7655785B1 (en) | 2002-11-14 | 2010-02-02 | Rosetta Genomics Ltd. | Bioinformatically detectable group of novel regulatory oligonucleotides and uses thereof |
US20040175732A1 (en) * | 2002-11-15 | 2004-09-09 | Rana Tariq M. | Identification of micrornas and their targets |
WO2004046324A2 (en) | 2002-11-15 | 2004-06-03 | University Of Massachusetts | Allele-targeted rna interference |
AU2003262277A1 (en) | 2002-12-03 | 2004-06-23 | Koken Co., Ltd. | Inhibitor of proliferation and/or infiltration of tumor cells |
US7851150B2 (en) | 2002-12-18 | 2010-12-14 | Third Wave Technologies, Inc. | Detection of small nucleic acids |
CA2510381C (en) * | 2002-12-18 | 2014-07-08 | Third Wave Technologies, Inc. | Detection of small nucleic acids |
JP2006526390A (ja) | 2003-01-13 | 2006-11-24 | エモリー ユニバーシティ | 正常細胞およびがん細胞における遺伝子発現を検出する方法 |
CN1761756B (zh) | 2003-01-16 | 2013-03-13 | 北卡罗来纳州大学 | 禽类物种中内源性原生殖细胞的耗减 |
WO2004066183A2 (en) * | 2003-01-22 | 2004-08-05 | European Molecular Biology Laboratory | Microrna |
US20040147027A1 (en) | 2003-01-28 | 2004-07-29 | Troy Carol M. | Complex for facilitating delivery of dsRNA into a cell and uses thereof |
CN1768139A (zh) * | 2003-02-10 | 2006-05-03 | 独立行政法人产业技术总合研究所 | 通过dna干扰调控基因的表达 |
US7816337B2 (en) | 2003-02-18 | 2010-10-19 | Roche Madison Inc. | Reversible attachment of a membrane active polymer to a polynucleotide |
US20040224337A1 (en) | 2003-03-04 | 2004-11-11 | Erik Foehr | Use of biomolecular targets in the treatment and visualization of tumors |
US20050164212A1 (en) * | 2003-03-06 | 2005-07-28 | Todd Hauser | Modulation of gene expression using DNA-RNA hybrids |
US20050112604A1 (en) | 2003-03-14 | 2005-05-26 | Akihide Fujimoto | Loss of heterozygosity of the DNA markers in the 12q22-23 region |
US7718364B2 (en) | 2003-03-25 | 2010-05-18 | John Wayne Cancer Institute | DNA markers for management of cancer |
WO2004090105A2 (en) * | 2003-04-02 | 2004-10-21 | Dharmacon, Inc. | Modified polynucleotides for use in rna interference |
US20040198640A1 (en) | 2003-04-02 | 2004-10-07 | Dharmacon, Inc. | Stabilized polynucleotides for use in RNA interference |
EP1608735A4 (en) | 2003-04-03 | 2008-11-05 | Alnylam Pharmaceuticals | RNAI CONJUGATES |
US20040229211A1 (en) | 2003-05-13 | 2004-11-18 | Yeung Wah Hin Alex | Sensitive diagnostic testing methodology using multiplex real time PCR with one dye (MOD) and its use as in severe acute respiratory syndrome (SARS) |
WO2004105573A2 (en) | 2003-05-21 | 2004-12-09 | The Wistar Institute Of Anatomy And Biology | Method of diagnosis of cancer based on gene expression profiles in cells |
ATE485394T1 (de) | 2003-06-02 | 2010-11-15 | Univ Massachusetts | Verfahren und zusammensetzungen zur verbesserung der wirksamkeit und spezifität von fnai |
US7750144B2 (en) | 2003-06-02 | 2010-07-06 | University Of Massachusetts | Methods and compositions for enhancing the efficacy and specificity of RNA silencing |
CA2528012C (en) | 2003-06-02 | 2015-11-24 | University Of Massachusetts | Methods and compositions for controlling efficacy of rna silencing |
US20050059024A1 (en) | 2003-07-25 | 2005-03-17 | Ambion, Inc. | Methods and compositions for isolating small RNA molecules |
WO2005013901A2 (en) * | 2003-07-31 | 2005-02-17 | Isis Pharmaceuticals, Inc. | Oligomeric compounds and compositions for use in modulation of small non-coding rnas |
US8106180B2 (en) * | 2003-08-07 | 2012-01-31 | Whitehead Institute For Biomedical Research | Methods and products for expression of micro RNAs |
US20050037362A1 (en) | 2003-08-11 | 2005-02-17 | Eppendorf Array Technologies, S.A. | Detection and quantification of siRNA on microarrays |
US20060183128A1 (en) | 2003-08-12 | 2006-08-17 | Epigenomics Ag | Methods and compositions for differentiating tissues for cell types using epigenetic markers |
WO2005017145A1 (ja) | 2003-08-13 | 2005-02-24 | Japan Biological Informatics Consortium | 機能性rnaが制御する被制御遺伝子の同定・予測方法及びその利用方法 |
CN1894407A (zh) | 2003-11-10 | 2007-01-10 | 诺松制药股份公司 | 特异性结合生物活性生长素释放肽的核酸 |
US20050130170A1 (en) | 2003-12-16 | 2005-06-16 | Jeanne Harvey | Identification and verification of methylation marker sequences |
US20050130172A1 (en) | 2003-12-16 | 2005-06-16 | Bayer Corporation | Identification and verification of methylation marker sequences |
WO2005078139A2 (en) * | 2004-02-09 | 2005-08-25 | Thomas Jefferson University | DIAGNOSIS AND TREATMENT OF CANCERS WITH MicroRNA LOCATED IN OR NEAR CANCER-ASSOCIATED CHROMOSOMAL FEATURES |
AU2005214904B2 (en) | 2004-02-13 | 2011-07-21 | Rockefeller University | Anti-microRNA oligonucleotide molecules |
US20050182005A1 (en) | 2004-02-13 | 2005-08-18 | Tuschl Thomas H. | Anti-microRNA oligonucleotide molecules |
KR100522307B1 (ko) * | 2004-02-19 | 2005-10-19 | 변영철 | 화장용브러시 |
US7402389B2 (en) | 2004-02-24 | 2008-07-22 | The Translational Genomics Research Institute (Tgen) | Compositions and methods for prognosis of cancers |
US20060195266A1 (en) | 2005-02-25 | 2006-08-31 | Yeatman Timothy J | Methods for predicting cancer outcome and gene signatures for use therein |
US8038996B2 (en) | 2004-03-27 | 2011-10-18 | University Of Arizona | Composition and method for cancer treatment |
US20060134639A1 (en) | 2004-04-06 | 2006-06-22 | Huffel Christophe V | Method for the determination of cellular transcriptional regulation |
US7365058B2 (en) * | 2004-04-13 | 2008-04-29 | The Rockefeller University | MicroRNA and methods for inhibiting same |
NZ551019A (en) | 2004-04-20 | 2009-08-28 | Genaco Biomedical Products Inc | Method for detecting ncRNA |
PL1747023T5 (pl) | 2004-05-04 | 2017-05-31 | Univ Leland Stanford Junior | Sposób i kompozycje do zmniejszania ilości genomu wirusowego HCV w komórkach docelowych |
CA2566519C (en) | 2004-05-14 | 2020-04-21 | Rosetta Genomics Ltd. | Micrornas and uses thereof |
WO2005116261A2 (en) | 2004-05-24 | 2005-12-08 | Albert Einstein College Of Medecine Of Yeshiva University | Rna expression microarrays |
EP2290068A3 (en) | 2004-05-28 | 2012-01-04 | Asuragen, Inc. | Methods and compositions involving microRNA |
US7575863B2 (en) | 2004-05-28 | 2009-08-18 | Applied Biosystems, Llc | Methods, compositions, and kits comprising linker probes for quantifying polynucleotides |
US20050287539A1 (en) | 2004-06-29 | 2005-12-29 | Emmanuel Labourier | Methods and compositions for preparing capped RNA |
AU2005328382C1 (en) | 2004-07-21 | 2013-01-24 | Alnylam Pharmaceuticals, Inc. | Oligonucleotides comprising a modified or non-natural nucleobase |
WO2006020768A2 (en) | 2004-08-10 | 2006-02-23 | Alnylam Pharmaceuticals, Inc. | Chemically modified oligonucleotides |
EP2338993B1 (en) | 2004-09-02 | 2013-06-12 | Yale University | Regulation of oncogenes by microRNAs |
US20060057595A1 (en) | 2004-09-16 | 2006-03-16 | Applera Corporation | Compositions, methods, and kits for identifying and quantitating small RNA molecules |
US7825229B2 (en) | 2005-03-25 | 2010-11-02 | Rosetta Genomics Ltd. | Lung cancer-related nucleic acids |
US20090186353A1 (en) | 2004-10-04 | 2009-07-23 | Rosetta Genomics Ltd. | Cancer-related nucleic acids |
US7592441B2 (en) | 2004-10-04 | 2009-09-22 | Rosetta Genomics Ltd | Liver cancer-related nucleic acids |
US7642348B2 (en) | 2004-10-04 | 2010-01-05 | Rosetta Genomics Ltd | Prostate cancer-related nucleic acids |
US20060078894A1 (en) | 2004-10-12 | 2006-04-13 | Winkler Matthew M | Methods and compositions for analyzing nucleic acids |
CA2588057A1 (en) | 2004-10-12 | 2006-04-20 | John Wayne Cancer Institute | Treatment of cancer and compositions |
FR2877350B1 (fr) | 2004-11-03 | 2010-08-27 | Centre Nat Rech Scient | IDENTIFICATION ET UTILISATION DE miRNAs IMPLIQUES DANS LA DIFFERENCIATION DE CELLULES ISSUES D'UNE LEUCEMIE MYELOIDE |
ES2503765T3 (es) | 2004-11-12 | 2014-10-07 | Asuragen, Inc. | Procedimientos y composiciones que implican miARN y moléculas inhibidoras de miARN |
US7074622B2 (en) | 2004-11-15 | 2006-07-11 | Eastman Kodak Company | Method and system for sorting and separating particles |
CA2589782A1 (en) | 2004-11-30 | 2006-06-08 | Veridex Llc | Lung cancer prognostics |
US20060154275A1 (en) | 2004-12-02 | 2006-07-13 | The Board Of Trustees Of The Leland Stanford Junior University | Regulated genes in cervical cancer |
US20060185027A1 (en) | 2004-12-23 | 2006-08-17 | David Bartel | Systems and methods for identifying miRNA targets and for altering miRNA and target expression |
EP1959012A3 (en) | 2004-12-29 | 2009-12-30 | Exiqon A/S | Novel oligonucleotide compositions and probe sequences useful for detection and analysis of microRNAs and their target mRNAs |
AU2006236453B2 (en) | 2005-01-25 | 2012-02-23 | Board Of Regents, The University Of Texas System | Delivery of siRNA by neutral lipid compositions |
EP1863516A2 (en) | 2005-02-08 | 2007-12-12 | Board of Regents, The University of Texas System | Compositions and methods involving mda-7 for the treatment of cancer |
US20090062184A1 (en) | 2005-03-24 | 2009-03-05 | Dainippon Sumitomo Pharma Co., Ltd. | Fine particulate preparation comprising complex of nucleic acid molecule and collagen |
US7495073B2 (en) | 2005-03-24 | 2009-02-24 | Asia Hepato Gene Company | Short isoform of Annexin A10 at chromosome 4q, termed Annexin 10s (ANXA10s) and methods of use |
GB2425311A (en) * | 2005-04-15 | 2006-10-25 | Ist Superiore Sanita | Micro RNA against kit protein |
JP2008539731A (ja) | 2005-05-02 | 2008-11-20 | コールド スプリング ハーバー ラボラトリー | 癌の診断及び治療のための組成物及び方法 |
US20070072201A1 (en) * | 2005-05-16 | 2007-03-29 | Kohne David E | Method for producing improved nucleic acid oligomer functional homogeneity and functional characteristic information and results and oligomer application results |
US20060265771A1 (en) * | 2005-05-17 | 2006-11-23 | Lewis David L | Monitoring microrna expression and function |
GB0601102D0 (en) | 2006-01-19 | 2006-03-01 | Nuclea Biomarkers Llc | Kinase Peptides And Antibodies |
US20070054287A1 (en) | 2005-05-31 | 2007-03-08 | Applera Corporation | Method for identifying medically important cell populations using micro rna as tissue specific biomarkers |
EP2377559A1 (en) | 2005-06-03 | 2011-10-19 | Southern Adelaide Health Service - Flinders Medical Centre | Targeting cells with altered microRNA expression |
US20070065844A1 (en) | 2005-06-08 | 2007-03-22 | Massachusetts Institute Of Technology | Solution-based methods for RNA expression profiling |
EP1896602A4 (en) | 2005-06-09 | 2009-08-12 | Epoch Biosciences Inc | IMPROVED METHODS OF AMPLIFICATION BASED ON PRIMERS |
US20060292616A1 (en) | 2005-06-23 | 2006-12-28 | U.S. Genomics, Inc. | Single molecule miRNA-based disease diagnostic methods |
KR101140575B1 (ko) * | 2005-06-30 | 2012-05-02 | 엘지디스플레이 주식회사 | 액정표시장치 검사공정 |
CN105902559A (zh) | 2005-08-01 | 2016-08-31 | 俄亥俄州立大学研究基金会 | 用于乳腺癌的诊断、预后和治疗的基于MicroRNA的方法和组合物 |
IL177006A0 (en) | 2005-08-02 | 2006-12-10 | Veridex Llc | Predicting bone relapse of breast cancer |
US20070213292A1 (en) | 2005-08-10 | 2007-09-13 | The Rockefeller University | Chemically modified oligonucleotides for use in modulating micro RNA and uses thereof |
US20070041934A1 (en) | 2005-08-12 | 2007-02-22 | Regents Of The University Of Michigan | Dendrimer based compositions and methods of using the same |
CN101296702B (zh) | 2005-09-12 | 2012-11-28 | 俄亥俄州立大学研究基金会 | 用于诊断或治疗bcl2相关癌症的组合物和方法 |
CA2627129A1 (en) | 2005-11-04 | 2007-05-18 | Merck & Co., Inc. | Methods of using saha and bortezomib for treating cancer |
US7390792B2 (en) | 2005-12-15 | 2008-06-24 | Board Of Regents, The University Of Texas System | MicroRNA1 therapies |
JP5713377B2 (ja) | 2005-12-28 | 2015-05-07 | ザ スクリプス リサーチ インスティテュート | 薬物標的としての天然アンチセンスおよび非コードrna転写物 |
US20100286044A1 (en) | 2005-12-29 | 2010-11-11 | Exiqon A/S | Detection of tissue origin of cancer |
AU2007205234B2 (en) | 2006-01-05 | 2012-07-12 | The Ohio State University Research Foundation | MicroRNA-based methods and compositions for the diagnosis, prognosis and treatment of lung cancer |
ES2545118T3 (es) | 2006-01-05 | 2015-09-08 | The Ohio State University Research Foundation | Métodos basados en microARN y composiciones para el diagnóstico y tratamiento de cánceres sólidos |
US7670840B2 (en) | 2006-01-05 | 2010-03-02 | The Ohio State University Research Foundation | Micro-RNA expression abnormalities of pancreatic, endocrine and acinar tumors |
WO2007087451A2 (en) | 2006-01-25 | 2007-08-02 | University Of Massachusetts | Compositions and methods for enhancing discriminatory rna interference |
EP2388327A1 (en) | 2006-01-27 | 2011-11-23 | Isis Pharmaceuticals, Inc. | Oligomeric compounds and compositions for the use in modulation of micrornas |
AU2007223311C1 (en) | 2006-03-02 | 2013-06-20 | The Board Of Regents Of The University Of Oklahoma | MicroRNA expression profile associated with pancreatic cancer |
US7955848B2 (en) | 2006-04-03 | 2011-06-07 | Trustees Of Dartmouth College | MicroRNA biomarkers for human breast and lung cancer |
US8106024B2 (en) | 2006-06-16 | 2012-01-31 | Taisho Pharmaceutical Co., Ltd. | Method of treating cancer with an RPN2 gene expression inhibitor |
US20080076674A1 (en) | 2006-07-06 | 2008-03-27 | Thomas Litman | Novel oligonucleotide compositions and probe sequences useful for detection and analysis of non coding RNAs associated with cancer |
ES2434075T3 (es) | 2006-07-13 | 2013-12-13 | The Ohio State University Research Foundation | MIR-203 para el diagnóstico de adenocarcinoma de colon con mal pronóstico de supervivencia |
US8466117B2 (en) | 2006-07-28 | 2013-06-18 | The Johns Hopkins University | Compositions and methods for modulating angiogenesis |
EP2145001A2 (en) | 2006-09-19 | 2010-01-20 | Asuragen, Inc. | Mir-15, mir-26, mir -31,mir -145, mir-147, mir-188, mir-215, mir-216 mir-331, mmu-mir-292-3p regulated genes and pathways as targets for therapeutic intervention |
CA2663878A1 (en) | 2006-09-19 | 2008-03-27 | Asuragen, Inc. | Mir-200 regulated genes and pathways as targets for therapeutic intervention |
JP5520605B2 (ja) | 2006-09-19 | 2014-06-11 | アシュラジェン インコーポレイテッド | 膵臓疾患で差次的に発現されるマイクロrnaおよびその使用 |
US20080131878A1 (en) | 2006-12-05 | 2008-06-05 | Asuragen, Inc. | Compositions and Methods for the Detection of Small RNA |
CA2671294A1 (en) | 2006-12-08 | 2008-06-19 | Asuragen, Inc. | Mir-21 regulated genes and pathways as targets for therapeutic intervention |
US20090092974A1 (en) | 2006-12-08 | 2009-04-09 | Asuragen, Inc. | Micrornas differentially expressed in leukemia and uses thereof |
EP2104737B1 (en) | 2006-12-08 | 2013-04-10 | Asuragen, INC. | Functions and targets of let-7 micro rnas |
AU2007333106A1 (en) | 2006-12-08 | 2008-06-19 | Asuragen, Inc. | miR-20 regulated genes and pathways as targets for therapeutic intervention |
US20090175827A1 (en) | 2006-12-29 | 2009-07-09 | Byrom Mike W | miR-16 REGULATED GENES AND PATHWAYS AS TARGETS FOR THERAPEUTIC INTERVENTION |
EP2111408A4 (en) | 2007-01-17 | 2010-02-03 | Univ Johns Hopkins | COMPOSITIONS AND METHODS COMPRISING MICROARNS FOR TREATING NEOPLASIA |
US8389486B2 (en) | 2007-01-26 | 2013-03-05 | Rosetta Genomics, Ltd | Methods for treating hematopoietic malignancies |
US20100310583A1 (en) | 2007-01-31 | 2010-12-09 | Immune Disease Institute | Let-7 microrna and mimetics thereof as therapeutics for cancer |
PL2147122T3 (pl) | 2007-04-20 | 2015-05-29 | Leadiant Biosciences Ltd | Enzymatyczna terapia przeciwnowotworowa |
CN101827941B (zh) | 2007-04-30 | 2014-07-16 | 俄亥俄州立大学研究基金会 | 用于区分胰腺癌与正常胰腺功能和/或慢性胰腺炎的方法 |
JP2010525826A (ja) * | 2007-05-03 | 2010-07-29 | ロゼッタ インファーマティックス エルエルシー | 癌を治療するためのmir34治療剤を含む組成物 |
US20090232893A1 (en) | 2007-05-22 | 2009-09-17 | Bader Andreas G | miR-143 REGULATED GENES AND PATHWAYS AS TARGETS FOR THERAPEUTIC INTERVENTION |
US20090131354A1 (en) | 2007-05-22 | 2009-05-21 | Bader Andreas G | miR-126 REGULATED GENES AND PATHWAYS AS TARGETS FOR THERAPEUTIC INTERVENTION |
AU2008261951A1 (en) | 2007-06-08 | 2008-12-18 | Asuragen, Inc. | miR-34 regulated genes and pathways as targets for therapeutic intervention |
US8361714B2 (en) | 2007-09-14 | 2013-01-29 | Asuragen, Inc. | Micrornas differentially expressed in cervical cancer and uses thereof |
US7993831B2 (en) | 2007-09-14 | 2011-08-09 | Asuragen, Inc. | Methods of normalization in microRNA detection assays |
WO2009052386A1 (en) | 2007-10-18 | 2009-04-23 | Asuragen, Inc. | Micrornas differentially expressed in lung diseases and uses thereof |
WO2009058907A2 (en) | 2007-10-29 | 2009-05-07 | Isis Pharmaceuticals, Inc. | Targeting micrornas for the treatment of liver cancer |
WO2009070805A2 (en) * | 2007-12-01 | 2009-06-04 | Asuragen, Inc. | Mir-124 regulated genes and pathways as targets for therapeutic intervention |
WO2009075787A1 (en) * | 2007-12-05 | 2009-06-18 | The Johns Hopkins University | Compositions and methods of treating neoplasia |
WO2009086156A2 (en) | 2007-12-21 | 2009-07-09 | Asuragen, Inc. | Mir-10 regulated genes and pathways as targets for therapeutic intervention |
EP2260110B1 (en) | 2008-02-08 | 2014-11-12 | Asuragen, INC. | miRNAs DIFFERENTIALLY EXPRESSED IN LYMPH NODES FROM CANCER PATIENTS |
EP2096171A1 (en) * | 2008-02-27 | 2009-09-02 | Julius-Maximilians-Universität Würzburg | MicroRNA (miRNA) and down-stream targets for diagnostic and therapeutic purposes |
EP2254668A4 (en) | 2008-02-28 | 2012-08-15 | Univ Ohio State Res Found | MICRORNA SIGNATURES ASSOCIATED WITH HUMAN CHRONIC LYMPHOCYTIC LEUKEMIA (CLL) AND THEIR USE |
WO2009111643A2 (en) | 2008-03-06 | 2009-09-11 | Asuragen, Inc. | Microrna markers for recurrence of colorectal cancer |
WO2009109665A1 (en) * | 2008-03-07 | 2009-09-11 | Santaris Pharma A/S | Pharmaceutical compositions for treatment of microrna related diseases |
EP2271757A2 (en) | 2008-03-26 | 2011-01-12 | Asuragen, INC. | Compositions and methods related to mir-16 and therapy of prostate cancer |
WO2009126726A1 (en) | 2008-04-08 | 2009-10-15 | Asuragen, Inc | Methods and compositions for diagnosing and modulating human papillomavirus (hpv) |
US8258111B2 (en) | 2008-05-08 | 2012-09-04 | The Johns Hopkins University | Compositions and methods related to miRNA modulation of neovascularization or angiogenesis |
US8900627B2 (en) | 2008-06-06 | 2014-12-02 | Mirna Therapeutics, Inc. | Compositions for the in vivo delivery of RNAi agents |
US20100090959A1 (en) | 2008-10-14 | 2010-04-15 | Sony Ericsson Mobile Communications Ab | Forming a keyboard from a combination of keys displayed on a touch sensitive display and on a separate keypad |
WO2010056737A2 (en) | 2008-11-11 | 2010-05-20 | Mirna Therapeutics, Inc. | Methods and compositions involving mirnas in cancer stem cells |
EP2379720B1 (en) * | 2009-01-20 | 2016-08-17 | Alona Zilberberg | Mir-21 promoter driven targeted cancer therapy |
US7665785B1 (en) | 2009-04-08 | 2010-02-23 | Newton Paul A | Column pipe catch tool |
US8778903B2 (en) * | 2009-10-21 | 2014-07-15 | Trustees Of Dartmouth College | MicroRNA-10 antagonists and MicroRNA-10 targets for use in the treatment of a glioma |
US8841273B2 (en) | 2009-10-28 | 2014-09-23 | Board Of Regents, The University Of Texas System | Methods and compositions for anti-EGFR treatment |
US8916533B2 (en) | 2009-11-23 | 2014-12-23 | The Ohio State University | Materials and methods useful for affecting tumor cell growth, migration and invasion |
US20130090366A1 (en) | 2009-11-24 | 2013-04-11 | Peter Jeffery Leedman | Modulation of epidermal growth factor receptor ligands |
WO2011088309A1 (en) | 2010-01-14 | 2011-07-21 | Regulus Therapeutics Inc. | Microrna compositions and methods |
WO2012041959A1 (en) | 2010-09-30 | 2012-04-05 | University Of Zurich | Treatment of b-cell lymphoma with microrna |
CA2826043A1 (en) * | 2011-02-03 | 2012-08-09 | Mirna Therapeutics, Inc. | Synthetic mimics of mir-124 |
CN103476931A (zh) * | 2011-02-03 | 2013-12-25 | 米尔纳医疗股份有限公司 | Mir-34的合成模拟物 |
WO2012135728A1 (en) | 2011-03-30 | 2012-10-04 | University Of Louisville Research Foundation, Inc. | Catalytic isomerisation of linear olefinic hydrocarbons |
TWI607016B (zh) | 2011-04-25 | 2017-12-01 | 瑞格勒斯治療學公司 | 微型rna化合物及調控mir-21活性之方法 |
AU2012347498A1 (en) | 2011-12-10 | 2014-06-26 | Ohio State Innovation Foundation | MiRNAs useful to reduce lung cancer tumorigenesis and chemotherapy resistance and related compositons and methods |
UA116639C2 (uk) | 2012-10-09 | 2018-04-25 | Рег'Юлес Терап'Ютікс Інк. | Способи лікування синдрому альпорта |
AU2014228166A1 (en) | 2013-03-15 | 2015-09-24 | Mirna Therapeutics, Inc. | Combination cancer treatments utilizing micrornas and EGFR-TKI inhibitors |
MX2015017749A (es) | 2013-06-24 | 2016-04-04 | Mirna Therapeutics Inc | Biomarcadores de actividad mir-34. |
WO2015153757A1 (en) | 2014-04-01 | 2015-10-08 | Mirna Therapeutics, Inc. | Microrna dosing regimens |
-
2005
- 2005-11-14 ES ES10183611.2T patent/ES2503765T3/es active Active
- 2005-11-14 EP EP10183567.6A patent/EP2281888B1/en not_active Not-in-force
- 2005-11-14 CA CA2857879A patent/CA2857879A1/en not_active Abandoned
- 2005-11-14 EP EP10183470A patent/EP2298893A1/en not_active Withdrawn
- 2005-11-14 EP EP10183515A patent/EP2302053A1/en not_active Withdrawn
- 2005-11-14 EP EP10183611.2A patent/EP2281889B1/en not_active Not-in-force
- 2005-11-14 CA CA2857901A patent/CA2857901A1/en not_active Abandoned
- 2005-11-14 ES ES10183490.1T patent/ES2534301T3/es active Active
- 2005-11-14 EP EP10183639A patent/EP2322616A1/en not_active Withdrawn
- 2005-11-14 ES ES10183567.6T patent/ES2534302T3/es active Active
- 2005-11-14 EP EP10183589.0A patent/EP2284265B1/en not_active Not-in-force
- 2005-11-14 EP EP10183525.4A patent/EP2298894B1/en not_active Not-in-force
- 2005-11-14 ES ES10183589.0T patent/ES2534303T3/es active Active
- 2005-11-14 CA CA2857881A patent/CA2857881A1/en not_active Abandoned
- 2005-11-14 EP EP10183490.1A patent/EP2302052B1/en not_active Not-in-force
- 2005-11-14 JP JP2007541398A patent/JP2008519606A/ja active Pending
- 2005-11-14 EP EP10183560A patent/EP2281887A1/en not_active Withdrawn
- 2005-11-14 CA CA2850323A patent/CA2850323A1/en not_active Abandoned
- 2005-11-14 EP EP10183456.2A patent/EP2292756B1/en not_active Not-in-force
- 2005-11-14 SI SI200531912T patent/SI2302055T1/sl unknown
- 2005-11-14 EP EP14177498.4A patent/EP2808390A1/en not_active Withdrawn
- 2005-11-14 EP EP10183481.0A patent/EP2281886B1/en not_active Not-in-force
- 2005-11-14 EP EP14177489.3A patent/EP2808389A1/en not_active Withdrawn
- 2005-11-14 ES ES10183462.0T patent/ES2534300T3/es active Active
- 2005-11-14 EP EP10183577.5A patent/EP2302055B1/en not_active Revoked
- 2005-11-14 ES ES10183456.2T patent/ES2503738T3/es active Active
- 2005-11-14 EP EP10183534.6A patent/EP2302054B1/en not_active Not-in-force
- 2005-11-14 ES ES10183577.5T patent/ES2507544T3/es active Active
- 2005-11-14 CA CA2857878A patent/CA2857878A1/en not_active Abandoned
- 2005-11-14 ES ES10183596.5T patent/ES2534304T3/es active Active
- 2005-11-14 AU AU2005333165A patent/AU2005333165B2/en not_active Ceased
- 2005-11-14 ES ES10183481.0T patent/ES2503739T3/es active Active
- 2005-11-14 US US11/273,640 patent/US8173611B2/en not_active Expired - Fee Related
- 2005-11-14 EP EP10183538.7A patent/EP2287303B1/en not_active Not-in-force
- 2005-11-14 ES ES10183525.4T patent/ES2503740T3/es active Active
- 2005-11-14 EP EP10183543.7A patent/EP2314688B1/en not_active Not-in-force
- 2005-11-14 EP EP10183462.0A patent/EP2302051B1/en not_active Not-in-force
- 2005-11-14 EP EP10183596.5A patent/EP2302056B1/en not_active Not-in-force
- 2005-11-14 ES ES10183534.6T patent/ES2503741T3/es active Active
- 2005-11-14 ES ES10183543.7T patent/ES2503743T3/es active Active
- 2005-11-14 DK DK10183577.5T patent/DK2302055T3/da active
- 2005-11-14 WO PCT/US2005/041162 patent/WO2006137941A2/en active Application Filing
- 2005-11-14 PL PL10183577T patent/PL2302055T3/pl unknown
- 2005-11-14 CA CA2857880A patent/CA2857880A1/en not_active Abandoned
- 2005-11-14 ES ES10183538.7T patent/ES2503742T3/es active Active
- 2005-11-14 EP EP10183451A patent/EP2292755A1/en not_active Withdrawn
- 2005-11-14 CA CA002587189A patent/CA2587189A1/en not_active Abandoned
- 2005-11-14 EP EP05858321A patent/EP1838852A2/en not_active Withdrawn
-
2007
- 2007-08-10 US US11/837,488 patent/US8058250B2/en not_active Expired - Fee Related
- 2007-08-10 US US11/837,490 patent/US7960359B2/en not_active Expired - Fee Related
- 2007-08-10 US US11/837,487 patent/US8563708B2/en not_active Expired - Fee Related
-
2010
- 2010-02-23 JP JP2010036925A patent/JP5389690B2/ja not_active Expired - Fee Related
-
2011
- 2011-07-25 US US13/190,232 patent/US20110313025A1/en not_active Abandoned
- 2011-11-17 US US13/299,255 patent/US8946177B2/en not_active Expired - Fee Related
-
2012
- 2012-07-05 JP JP2012150997A patent/JP5596085B2/ja not_active Expired - Fee Related
-
2013
- 2013-02-07 US US13/761,284 patent/US20130143945A1/en not_active Abandoned
- 2013-05-03 US US13/887,008 patent/US20130303591A1/en not_active Abandoned
- 2013-08-28 US US14/012,302 patent/US8765709B2/en not_active Expired - Fee Related
- 2013-09-05 JP JP2013183871A patent/JP5620556B2/ja not_active Expired - Fee Related
-
2014
- 2014-04-16 US US14/254,532 patent/US9051571B2/en not_active Expired - Fee Related
- 2014-05-26 JP JP2014107664A patent/JP2014217381A/ja active Pending
- 2014-07-24 JP JP2014150350A patent/JP2014217385A/ja active Pending
- 2014-07-24 JP JP2014150384A patent/JP2014217386A/ja active Pending
- 2014-07-24 JP JP2014150321A patent/JP2014217384A/ja active Pending
- 2014-07-24 JP JP2014150365A patent/JP2014223080A/ja active Pending
- 2014-07-24 JP JP2014150414A patent/JP2014217387A/ja active Pending
- 2014-08-13 US US14/459,119 patent/US20140348907A1/en not_active Abandoned
- 2014-08-13 US US14/459,192 patent/US20140348908A1/en not_active Abandoned
- 2014-08-13 US US14/459,182 patent/US9382537B2/en not_active Expired - Fee Related
- 2014-08-13 US US14/459,074 patent/US9068219B2/en not_active Expired - Fee Related
- 2014-08-13 US US14/459,158 patent/US20150005366A1/en not_active Abandoned
-
2015
- 2015-05-14 US US14/712,591 patent/US9506061B2/en not_active Expired - Fee Related
- 2015-06-03 HK HK15105287.4A patent/HK1204656A1/xx unknown
- 2015-06-09 US US14/735,046 patent/US20150275213A1/en not_active Abandoned
- 2015-06-12 US US14/738,728 patent/US20150299705A1/en not_active Abandoned
- 2015-06-12 US US14/738,706 patent/US20150284719A1/en not_active Abandoned
- 2015-06-12 US US14/738,716 patent/US20150284720A1/en not_active Abandoned
- 2015-06-12 US US14/738,734 patent/US20150344883A1/en not_active Abandoned
- 2015-06-12 US US14/738,646 patent/US20150342981A1/en not_active Abandoned
- 2015-06-16 US US14/741,064 patent/US9447414B2/en not_active Expired - Fee Related
- 2015-08-31 US US14/841,377 patent/US20150361431A1/en not_active Abandoned
-
2016
- 2016-03-31 JP JP2016069966A patent/JP2016165292A/ja active Pending
- 2016-10-20 US US15/298,781 patent/US20170037404A1/en not_active Abandoned
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
ES2534304T3 (es) | Procedimientos y composiciones que implican miARN y moléculas inhibidoras de miARN | |
DOP2010000304A (es) | Composiciones y metodos de preparacion y uso de las mismas | |
BRPI0807132A2 (pt) | enzimas para o tratamento de lignocelulósicos, ácidos nucléicos que codificam as mesmas, e metodos e uso das mesmas | |
BRPI0817811A2 (pt) | Xilanases, ácidos nucleicos que codificam as mesmas e métodos para fabricação e uso das mesmas. | |
AR066395A1 (es) | Reovirus que tienen secuencias modificadas | |
DOP2011000084A (es) | Uso de ditiina-tetracarboximidas para combatir hongos fitopatogenos | |
BRPI0905663A2 (pt) | "emulsão estável, processo de preparação da emulsão estável e uso emulsão" | |
BRPI0718688A2 (pt) | Composições de baixa irritação e métodos para preparar as mesmas. | |
NI200500164A (es) | Nueva difenilazetidinona con caracteristicas fisiologicas mejoradas, correspondiente metodo de produccion, medicamentos que contienen dicho compuesto y su uso. | |
BRPI0804068A2 (pt) | composições para uso no escurecimento da pele | |
BRPI0907663A2 (pt) | ''composição que compreende hfo- 123 yf, composição que compreende hcfc-243db, composição que compreende hcfo- 1233xf, composição que comproeende hcfc- 244bb, uso das composições e método de uso das composições. | |
AR053066A1 (es) | Arabinofuranosidasas | |
UY31543A1 (es) | Sistema de administracion de rnai de interferencia y usos del mismo | |
BRPI0606112A2 (pt) | 3 - heteroaril - 3 - hidróxi - 2 - amino - propil aminas e compostos relacionados, bem como uso dos mesmos e composição farmacêutica | |
IL186458A0 (en) | Skin enrichment using coq10 as the delivery system | |
WO2006018836A3 (en) | Nucleic acid constructs and cells, and methods utilizing same for modifying the electrophysiological function of excitable tissues | |
BR112013025777A2 (pt) | imidazopiridazinas como inibidores da quinase akt | |
UY28662A1 (es) | Agente endoparasiticida para administracion topica | |
EA200701029A1 (ru) | Новая композиция для облегчения человеческих родов | |
BRPI0719497A2 (pt) | "composição, processo de preparação de uma composição, usos de uma composição e uso coméstico de uma composição" | |
CR9786A (es) | Compuestos de bencimidazol-tiofeno | |
PA8657801A1 (es) | Aminalcoholes triciclicos, procedimientos para su preparacion | |
CR8360A (es) | 1,3 dimetilbutilcarboxanilidas | |
CR7977A (es) | Anilidas de acido trifluorometil-tiofencarboxilico y su uso como fungicidas | |
UY29236A1 (es) | 2-alcoxi-3,4,5-trihidroxi-alquilamidas. su preparación, composiciones que las contienen y su utilización. |