|
US3687808A
(en)
|
1969-08-14 |
1972-08-29 |
Univ Leland Stanford Junior |
Synthetic polynucleotides
|
|
AU637800B2
(en)
|
1989-08-31 |
1993-06-10 |
City Of Hope |
Chimeric dna-rna catalytic sequences
|
|
US5495009A
(en)
|
1989-10-24 |
1996-02-27 |
Gilead Sciences, Inc. |
Oligonucleotide analogs containing thioformacetal linkages
|
|
US5264562A
(en)
|
1989-10-24 |
1993-11-23 |
Gilead Sciences, Inc. |
Oligonucleotide analogs with novel linkages
|
|
US5264564A
(en)
|
1989-10-24 |
1993-11-23 |
Gilead Sciences |
Oligonucleotide analogs with novel linkages
|
|
US6005087A
(en)
|
1995-06-06 |
1999-12-21 |
Isis Pharmaceuticals, Inc. |
2'-modified oligonucleotides
|
|
US5670633A
(en)
|
1990-01-11 |
1997-09-23 |
Isis Pharmaceuticals, Inc. |
Sugar modified oligonucleotides that detect and modulate gene expression
|
|
US6153737A
(en)
|
1990-01-11 |
2000-11-28 |
Isis Pharmaceuticals, Inc. |
Derivatized oligonucleotides having improved uptake and other properties
|
|
US5214136A
(en)
|
1990-02-20 |
1993-05-25 |
Gilead Sciences, Inc. |
Anthraquinone-derivatives oligonucleotides
|
|
US5962219A
(en)
|
1990-06-11 |
1999-10-05 |
Nexstar Pharmaceuticals, Inc. |
Systematic evolution of ligands by exponential enrichment: chemi-selex
|
|
US5138045A
(en)
|
1990-07-27 |
1992-08-11 |
Isis Pharmaceuticals |
Polyamine conjugated oligonucleotides
|
|
WO1992007065A1
(en)
|
1990-10-12 |
1992-04-30 |
MAX-PLANCK-Gesellschaft zur Förderung der Wissenschaften e.V. |
Modified ribozymes
|
|
DE4216134A1
(de)
|
1991-06-20 |
1992-12-24 |
Europ Lab Molekularbiolog |
Synthetische katalytische oligonukleotidstrukturen
|
|
US6335434B1
(en)
|
1998-06-16 |
2002-01-01 |
Isis Pharmaceuticals, Inc., |
Nucleosidic and non-nucleosidic folate conjugates
|
|
US5652094A
(en)
|
1992-01-31 |
1997-07-29 |
University Of Montreal |
Nucleozymes
|
|
US6469158B1
(en)
|
1992-05-14 |
2002-10-22 |
Ribozyme Pharmaceuticals, Incorporated |
Synthesis, deprotection, analysis and purification of RNA and ribozymes
|
|
WO1993023569A1
(en)
|
1992-05-11 |
1993-11-25 |
Ribozyme Pharmaceuticals, Inc. |
Method and reagent for inhibiting viral replication
|
|
US5977343A
(en)
|
1992-05-14 |
1999-11-02 |
Ribozyme Pharmaceuticals, Inc. |
Synthesis, deprotection, analysis and purification of RNA and ribozymes
|
|
US5804683A
(en)
|
1992-05-14 |
1998-09-08 |
Ribozyme Pharmaceuticals, Inc. |
Deprotection of RNA with alkylamine
|
|
FI946201A0
(fi)
|
1992-07-02 |
1994-12-30 |
Hybridon Inc |
Itsestabiloidut oligonukleotidit terapeuttisina aineina
|
|
EP1251170A3
(en)
|
1992-07-17 |
2002-10-30 |
Ribozyme Pharmaceuticals, Inc. |
Method and reagent for treatment of NF-kappaB dependent animal diseases
|
|
US6174868B1
(en)
|
1992-09-10 |
2001-01-16 |
Isis Pharmaceuticals, Inc. |
Compositions and methods for treatment of hepatitis C virus-associated diseases
|
|
US6235886B1
(en)
|
1993-09-03 |
2001-05-22 |
Isis Pharmaceuticals, Inc. |
Methods of synthesis and use
|
|
US5767264A
(en)
|
1993-01-22 |
1998-06-16 |
Mta Zozponti Kemiai Kutato Intezet |
Oligodeoxynucleotides containing 5-alkyl, 5-(1-alkenyl)- and 5-(1-alkynl) pyrimidines
|
|
EP0681482B1
(en)
|
1993-01-22 |
2005-12-07 |
University Research Corporation |
Localization of therapeutic agents
|
|
US6410322B1
(en)
|
1993-07-27 |
2002-06-25 |
Hybridon Inc |
Antisense oligonucleotide inhibition of vascular endothelial growth factor expression
|
|
WO1995006731A2
(en)
|
1993-09-02 |
1995-03-09 |
Ribozyme Pharmaceuticals, Inc. |
Non-nucleotide containing enzymatic nucleic acid
|
|
CA2170869C
(en)
|
1993-09-03 |
1999-09-14 |
Phillip Dan Cook |
Amine-derivatized nucleosides and oligonucleosides
|
|
US5624803A
(en)
|
1993-10-14 |
1997-04-29 |
The Regents Of The University Of California |
In vivo oligonucleotide generator, and methods of testing the binding affinity of triplex forming oligonucleotides derived therefrom
|
|
US5861288A
(en)
|
1993-10-18 |
1999-01-19 |
Ribozyme Pharmaceuticals, Inc. |
Catalytic DNA
|
|
ES2127948T3
(es)
|
1993-10-27 |
1999-05-01 |
Ribozyme Pharm Inc |
Oligonucleotidos modificados en la posicion 2'-amido y 2'-peptido.
|
|
DE4338704A1
(de)
|
1993-11-12 |
1995-05-18 |
Hoechst Ag |
Stabilisierte Oligonucleotide und deren Verwendung
|
|
US5587471A
(en)
|
1994-01-11 |
1996-12-24 |
Isis Pharmaceuticals, Inc. |
Method of making oligonucleotide libraries
|
|
US5902880A
(en)
|
1994-08-19 |
1999-05-11 |
Ribozyme Pharmaceuticals, Inc. |
RNA polymerase III-based expression of therapeutic RNAs
|
|
US5627053A
(en)
|
1994-03-29 |
1997-05-06 |
Ribozyme Pharmaceuticals, Inc. |
2'deoxy-2'-alkylnucleotide containing nucleic acid
|
|
US6447796B1
(en)
|
1994-05-16 |
2002-09-10 |
The United States Of America As Represented By The Secretary Of The Army |
Sustained release hydrophobic bioactive PLGA microspheres
|
|
US6146886A
(en)
|
1994-08-19 |
2000-11-14 |
Ribozyme Pharmaceuticals, Inc. |
RNA polymerase III-based expression of therapeutic RNAs
|
|
US5753613A
(en)
|
1994-09-30 |
1998-05-19 |
Inex Pharmaceuticals Corporation |
Compositions for the introduction of polyanionic materials into cells
|
|
US5885613A
(en)
|
1994-09-30 |
1999-03-23 |
The University Of British Columbia |
Bilayer stabilizing components and their use in forming programmable fusogenic liposomes
|
|
US5820873A
(en)
|
1994-09-30 |
1998-10-13 |
The University Of British Columbia |
Polyethylene glycol modified ceramide lipids and liposome uses thereof
|
|
AU4412096A
(en)
|
1994-12-13 |
1996-07-03 |
Ribozyme Pharmaceuticals, Inc. |
Method and reagent for treatment of arthritic conditions, induction of graft tolerance and reversal of immune responses
|
|
US5716824A
(en)
|
1995-04-20 |
1998-02-10 |
Ribozyme Pharmaceuticals, Inc. |
2'-O-alkylthioalkyl and 2-C-alkylthioalkyl-containing enzymatic nucleic acids (ribozymes)
|
|
US5981501A
(en)
|
1995-06-07 |
1999-11-09 |
Inex Pharmaceuticals Corp. |
Methods for encapsulating plasmids in lipid bilayers
|
|
CA2222328C
(en)
|
1995-06-07 |
2012-01-10 |
Inex Pharmaceuticals Corporation |
Lipid-nucleic acid particles prepared via a hydrophobic lipid-nucleic acid complex intermediate and use for gene transfer
|
|
US5705385A
(en)
|
1995-06-07 |
1998-01-06 |
Inex Pharmaceuticals Corporation |
Lipid-nucleic acid particles prepared via a hydrophobic lipid-nucleic acid complex intermediate and use for gene transfer
|
|
US7422902B1
(en)
|
1995-06-07 |
2008-09-09 |
The University Of British Columbia |
Lipid-nucleic acid particles prepared via a hydrophobic lipid-nucleic acid complex intermediate and use for gene transfer
|
|
US5968909A
(en)
|
1995-08-04 |
1999-10-19 |
Hybridon, Inc. |
Method of modulating gene expression with reduced immunostimulatory response
|
|
JP2000501414A
(ja)
|
1995-11-22 |
2000-02-08 |
ザ・ジョンズ・ホプキンス・ユニバーシティー |
生体分子の細胞取り込みを高めるリガンド
|
|
DE69637256T2
(de)
|
1996-01-16 |
2008-06-19 |
Sirna Therapeutics, Inc., Boulder |
Synthese von Methoxynukleoside und enzymatische Nukleisäure Moleküle
|
|
US5998203A
(en)
|
1996-04-16 |
1999-12-07 |
Ribozyme Pharmaceuticals, Inc. |
Enzymatic nucleic acids containing 5'-and/or 3'-cap structures
|
|
US5898031A
(en)
|
1996-06-06 |
1999-04-27 |
Isis Pharmaceuticals, Inc. |
Oligoribonucleotides for cleaving RNA
|
|
US5849902A
(en)
|
1996-09-26 |
1998-12-15 |
Oligos Etc. Inc. |
Three component chimeric antisense oligonucleotides
|
|
US6248878B1
(en)
|
1996-12-24 |
2001-06-19 |
Ribozyme Pharmaceuticals, Inc. |
Nucleoside analogs
|
|
EP0948511B1
(en)
|
1996-12-24 |
2006-10-18 |
Sirna Therapeutics, Inc. |
Chemical synthesis of nucleosides analogs and their incorporation into polynucleotides
|
|
US6001311A
(en)
|
1997-02-05 |
1999-12-14 |
Protogene Laboratories, Inc. |
Apparatus for diverse chemical synthesis using two-dimensional array
|
|
US6235310B1
(en)
|
1997-04-04 |
2001-05-22 |
Valentis, Inc. |
Methods of delivery using cationic lipids and helper lipids
|
|
WO1998051278A2
(en)
|
1997-05-14 |
1998-11-19 |
Inex Pharmaceuticals Corporation |
High efficiency encapsulation of charged therapeutic agents in lipid vesicles
|
|
US6835395B1
(en)
|
1997-05-14 |
2004-12-28 |
The University Of British Columbia |
Composition containing small multilamellar oligodeoxynucleotide-containing lipid vesicles
|
|
ES2212305T3
(es)
|
1997-06-23 |
2004-07-16 |
Alza Corporation |
Polinucleotidos encapsulados en liposomas, composicion y procedimiento.
|
|
US6395713B1
(en)
|
1997-07-23 |
2002-05-28 |
Ribozyme Pharmaceuticals, Inc. |
Compositions for the delivery of negatively charged molecules
|
|
TW589189B
(en)
|
1997-08-04 |
2004-06-01 |
Scras |
Kit containing at least one double-stranded RNA combined with at least one anti-viral agent for therapeutic use in the treatment of a viral disease, notably of viral hepatitis
|
|
CA2303299C
(en)
|
1997-09-12 |
2016-02-23 |
Exiqon A/S |
Oligonucleotide analogues
|
|
CA2315256A1
(en)
|
1997-12-16 |
1999-06-24 |
Valentis, Inc. |
Needle-free injection of formulated nucleic acid molecules
|
|
US6506559B1
(en)
|
1997-12-23 |
2003-01-14 |
Carnegie Institute Of Washington |
Genetic inhibition by double-stranded RNA
|
|
EP2138191A1
(en)
|
1998-01-05 |
2009-12-30 |
University Of Washington |
Enhanced transport using membrane disruptive agents
|
|
US6410328B1
(en)
|
1998-02-03 |
2002-06-25 |
Protiva Biotherapeutics Inc. |
Sensitizing cells to compounds using lipid-mediated gene and compound delivery
|
|
WO1999054459A2
(en)
|
1998-04-20 |
1999-10-28 |
Ribozyme Pharmaceuticals, Inc. |
Nucleic acid molecules with novel chemical compositions capable of modulating gene expression
|
|
JP2002512794A
(ja)
|
1998-04-29 |
2002-05-08 |
リボザイム・ファーマシューティカルズ・インコーポレーテッド |
ヌクレオチド三リン酸およびリボザイム内へのそれらの取り込み
|
|
GB9827152D0
(en)
|
1998-07-03 |
1999-02-03 |
Devgen Nv |
Characterisation of gene function using double stranded rna inhibition
|
|
WO2000003683A2
(en)
|
1998-07-20 |
2000-01-27 |
Inex Pharmaceuticals Corporation |
Liposomal encapsulated nucleic acid-complexes
|
|
WO2000025248A2
(en)
|
1998-10-26 |
2000-05-04 |
Intervu, Inc. |
Audience management for interactive network events
|
|
WO2000044914A1
(en)
|
1999-01-28 |
2000-08-03 |
Medical College Of Georgia Research Institute, Inc. |
Composition and method for in vivo and in vitro attenuation of gene expression using double stranded rna
|
|
DE19956568A1
(de)
|
1999-01-30 |
2000-08-17 |
Roland Kreutzer |
Verfahren und Medikament zur Hemmung der Expression eines vorgegebenen Gens
|
|
JP2002537828A
(ja)
|
1999-03-10 |
2002-11-12 |
フォゲン リミティド |
細胞への物質のデリバリー
|
|
EP1161439B1
(en)
|
1999-03-18 |
2010-04-21 |
Exiqon A/S |
Xylo-lna analogues
|
|
DK1163250T3
(da)
|
1999-03-24 |
2006-11-13 |
Exiqon As |
Forbedret syntese af [2.2.1]bicyclonukleosider
|
|
NZ514348A
(en)
|
1999-05-04 |
2004-05-28 |
Exiqon As |
L-ribo-LNA analogues
|
|
KR100758158B1
(ko)
|
1999-07-14 |
2007-09-12 |
알자 코포레이션 |
중성 지질중합체 및 그를 함유하는 리포솜 조성물
|
|
JP2004512810A
(ja)
|
1999-08-31 |
2004-04-30 |
サーナ・セラピューティクス・インコーポレイテッド |
核酸に基づく遺伝子発現の調節剤
|
|
IL148916A0
(en)
|
1999-10-04 |
2002-09-12 |
Exiqon As |
Design of high affinity rnase h recruiting oligonucleotide
|
|
EP1235842A4
(en)
|
1999-10-15 |
2003-04-23 |
Univ Massachusetts |
Rna interference pathway genes as tools for targeted genetic interference
|
|
GB9927444D0
(en)
|
1999-11-19 |
2000-01-19 |
Cancer Res Campaign Tech |
Inhibiting gene expression
|
|
DE10100586C1
(de)
|
2001-01-09 |
2002-04-11 |
Ribopharma Ag |
Verfahren zur Hemmung der Expression eines Ziegens
|
|
DE10160151A1
(de)
|
2001-01-09 |
2003-06-26 |
Ribopharma Ag |
Verfahren zur Hemmung der Expression eines vorgegebenen Zielgens
|
|
US6602857B1
(en)
|
2000-01-18 |
2003-08-05 |
Isis Pharmaceuticals, Inc. |
Antisense modulation of PTP1B expression
|
|
US6261840B1
(en)
|
2000-01-18 |
2001-07-17 |
Isis Pharmaceuticals, Inc. |
Antisense modulation of PTP1B expression
|
|
US7491805B2
(en)
|
2001-05-18 |
2009-02-17 |
Sirna Therapeutics, Inc. |
Conjugates and compositions for cellular delivery
|
|
WO2003070918A2
(en)
|
2002-02-20 |
2003-08-28 |
Ribozyme Pharmaceuticals, Incorporated |
Rna interference by modified short interfering nucleic acid
|
|
US8273866B2
(en)
|
2002-02-20 |
2012-09-25 |
Merck Sharp & Dohme Corp. |
RNA interference mediated inhibition of gene expression using chemically modified short interfering nucleic acid (SINA)
|
|
WO2005041859A2
(en)
|
2003-04-30 |
2005-05-12 |
Sirna Therapeutics, Inc. |
Conjugates and compositions for cellular delivery.
|
|
US6401406B1
(en)
|
2000-02-11 |
2002-06-11 |
Domald K. Komara |
Retainment device for concrete block inspection plates
|
|
US7833992B2
(en)
|
2001-05-18 |
2010-11-16 |
Merck Sharpe & Dohme |
Conjugates and compositions for cellular delivery
|
|
US20070026394A1
(en)
|
2000-02-11 |
2007-02-01 |
Lawrence Blatt |
Modulation of gene expression associated with inflammation proliferation and neurite outgrowth using nucleic acid based technologies
|
|
US8202979B2
(en)
|
2002-02-20 |
2012-06-19 |
Sirna Therapeutics, Inc. |
RNA interference mediated inhibition of gene expression using chemically modified short interfering nucleic acid
|
|
ATE450621T2
(de)
|
2000-03-30 |
2009-12-15 |
Whitehead Biomedical Inst |
Mediatoren von rns-interferenz, die rns- sequenzspezifisch sind
|
|
US20030190635A1
(en)
|
2002-02-20 |
2003-10-09 |
Mcswiggen James A. |
RNA interference mediated treatment of Alzheimer's disease using short interfering RNA
|
|
US6613567B1
(en)
|
2000-09-15 |
2003-09-02 |
Isis Pharmaceuticals, Inc. |
Antisense inhibition of Her-2 expression
|
|
WO2002028875A2
(en)
|
2000-10-04 |
2002-04-11 |
Cureon A/S |
Improved synthesis of purine locked nucleic acid analogues
|
|
US7427394B2
(en)
|
2000-10-10 |
2008-09-23 |
Massachusetts Institute Of Technology |
Biodegradable poly(β-amino esters) and uses thereof
|
|
US6998115B2
(en)
|
2000-10-10 |
2006-02-14 |
Massachusetts Institute Of Technology |
Biodegradable poly(β-amino esters) and uses thereof
|
|
KR100872437B1
(ko)
|
2000-12-01 |
2008-12-05 |
막스-플랑크-게젤샤프트 츄어 푀르더룽 데어 비쎈샤프텐 에.파우. |
Ｒｎａ 간섭을 매개하는 작은 ｒｎａ 분자
|
|
WO2002043771A2
(en)
|
2000-12-01 |
2002-06-06 |
Cell Works Inc. |
Conjugates of glycosylated/galactosylated peptide
|
|
US20020130430A1
(en)
|
2000-12-29 |
2002-09-19 |
Castor Trevor Percival |
Methods for making polymer microspheres/nanospheres and encapsulating therapeutic proteins and other products
|
|
WO2004028341A2
(en)
|
2001-03-19 |
2004-04-08 |
Decode Genetics Ehf. |
Susceptibility gene for human stroke; methods of treatment
|
|
US20050164220A1
(en)
|
2001-03-19 |
2005-07-28 |
Decode Genetics Ehf. |
Susceptibility gene for human stroke: method of treatment
|
|
EP1383782A1
(en)
|
2001-03-26 |
2004-01-28 |
Sirna Therpeutics, Inc. |
Oligonucleotide mediated inhibition of hepatitis b virus and hepatitis c virus replication
|
|
US20030077829A1
(en)
|
2001-04-30 |
2003-04-24 |
Protiva Biotherapeutics Inc.. |
Lipid-based formulations
|
|
WO2002094250A2
(en)
|
2001-05-18 |
2002-11-28 |
Cureon A/S |
Therapeutic uses of lna-modified oligonucleotides in infectious diseases
|
|
WO2003070887A2
(en)
|
2002-02-20 |
2003-08-28 |
Sirna Therapeutics, Inc. |
RNA INTERFERENCE MEDIATED INHIBITION OF POLYCOMB GROUP PROTEIN EZH2 GENE EXPRESSION USING SHORT INTERFERING NUCLEIC ACID (siNA)
|
|
US20030175950A1
(en)
|
2001-05-29 |
2003-09-18 |
Mcswiggen James A. |
RNA interference mediated inhibition of HIV gene expression using short interfering RNA
|
|
WO2003070197A2
(en)
|
2002-02-20 |
2003-08-28 |
Sirna Therapeutics, Inc. |
RNA INTERFERENCE MEDIATED INHIBITION OF TGF-BETA AND TGF-BETA RECEPTOR GENE EXPRESSION USING SHORT INTERFERING NUCLEIC ACID (siNA)
|
|
WO2003072590A1
(en)
|
2002-02-20 |
2003-09-04 |
Sirna Therapeutics, Inc. |
Rna interference mediated inhibition of map kinase genes
|
|
WO2003070910A2
(en)
|
2002-02-20 |
2003-08-28 |
Ribozyme Pharmaceuticals, Incorporated |
INHIBITION OF VASCULAR ENDOTHELIAL GROWTH FACTOR (VEGF) AND VEGF RECEPTOR GENE EXPRESSION USING SHORT INTERFERING NUCLEIC ACID (siNA)
|
|
WO2003070969A2
(en)
|
2002-02-20 |
2003-08-28 |
Sirna Therapeutics, Inc. |
RNA INTERFERENCE MEDIATED INHIBITION OF BCL2 GENE EXPRESSION USING SHORT INTERFERING NUCLEIC ACID (siNA)
|
|
US20050196781A1
(en)
|
2001-05-18 |
2005-09-08 |
Sirna Therapeutics, Inc. |
RNA interference mediated inhibition of STAT3 gene expression using short interfering nucleic acid (siNA)
|
|
WO2003070884A2
(en)
|
2002-02-20 |
2003-08-28 |
Sirna Therapeutics, Inc. |
RNA INTERFERENCE MEDIATED INHIBITION OF MDR P-GLYCOPROTEIN GENE EXPRESSION USING SHORT INTERFERING NUCLEIC ACID (siNA)
|
|
CA2526831C
(en)
|
2001-05-18 |
2012-07-31 |
Sirna Therapeutics, Inc. |
Rna interference mediated inhibition of gene expression using chemically modified short interfering nucleic acid (sina)
|
|
WO2003070912A2
(en)
|
2001-06-06 |
2003-08-28 |
Sirna Therapeutics, Inc. |
RNA INTERFERENCE MEDIATED INHIBITION OF EPIDERMAL GROWTH FACTOR RECEPTOR GENE EXPRESSION USING SHORT INTERFERING NUCLEIC ACID (siNA)
|
|
EP1572067A4
(en)
|
2001-05-18 |
2009-05-13 |
Sirna Therapeutics Inc |
CONJUGATES AND COMPOSITIONS FOR CELLULAR RELEASE
|
|
US20040019001A1
(en)
|
2002-02-20 |
2004-01-29 |
Mcswiggen James A. |
RNA interference mediated inhibition of protein typrosine phosphatase-1B (PTP-1B) gene expression using short interfering RNA
|
|
US20030130186A1
(en)
|
2001-07-20 |
2003-07-10 |
Chandra Vargeese |
Conjugates and compositions for cellular delivery
|
|
US20050148530A1
(en)
|
2002-02-20 |
2005-07-07 |
Sirna Therapeutics, Inc. |
RNA interference mediated inhibition of vascular endothelial growth factor and vascular endothelial growth factor receptor gene expression using short interfering nucleic acid (siNA)
|
|
WO2003072705A2
(en)
|
2002-02-20 |
2003-09-04 |
Sirna Therapeutics, Inc. |
Rna interference mediated inhibition of cyclin d1 gene expression using short interfering nucleic acid (sina)
|
|
US7109165B2
(en)
|
2001-05-18 |
2006-09-19 |
Sirna Therapeutics, Inc. |
Conjugates and compositions for cellular delivery
|
|
WO2004097020A2
(en)
|
2003-04-25 |
2004-11-11 |
Sirna Therapeutics, Inc. |
Rna interference mediated inhibition of map kinase gene expression
|
|
CA2448320A1
(en)
|
2001-05-29 |
2002-12-05 |
Sirna Therapeutics, Inc. |
Ribozyme based treatment of female reproductive diseases
|
|
JP4402454B2
(ja)
|
2001-07-12 |
2010-01-20 |
サンタリス ファーマ アー／エス |
Ｌｎａホスホラミダイトの製造法
|
|
DE60237696D1
(de)
|
2001-08-01 |
2010-10-28 |
Univ Utah |
Am n-terminus trunkierte isoformen von zyklischen phosphodiesterasen pde3a
|
|
US20050191627A1
(en)
|
2001-09-28 |
2005-09-01 |
Incyte Corporation |
Enzymes
|
|
DE60216798T2
(de)
*
|
2001-10-29 |
2007-10-18 |
Mcgill University, Montreal |
Azyklische linker enthaltende oligonukleotide und deren verwendungen
|
|
US7060498B1
(en)
|
2001-11-28 |
2006-06-13 |
Genta Salus Llc |
Polycationic water soluble copolymer and method for transferring polyanionic macromolecules across biological barriers
|
|
US7141540B2
(en)
|
2001-11-30 |
2006-11-28 |
Genta Salus Llc |
Cyclodextrin grafted biocompatible amphilphilic polymer and methods of preparation and use thereof
|
|
US20050118594A1
(en)
|
2001-12-14 |
2005-06-02 |
Chawla Narinder K. |
Enzymes
|
|
JP2005517450A
(ja)
|
2002-02-20 |
2005-06-16 |
サーナ・セラピューティクス・インコーポレイテッド |
短干渉核酸（ｓｉＮＡ）を用いるＲＮＡ干渉媒介性標的発見および標的評価
|
|
EP1448580A4
(en)
|
2002-02-20 |
2005-07-20 |
Sirna Therapeutics Inc |
INFERIATION OF GENE EXPRESSION OF PROLIFERATING CELL NUCLEAR ANTIGEN (PCNA) AND USE OF SHORT INTERFERING NUCLEIC ACID (SINA) BY RNA INTERFERENCE
|
|
EP1432725A4
(en)
|
2002-02-20 |
2005-03-30 |
Sirna Therapeutics Inc |
RNA INTERFERENCE-MEDIATED INHIBITION OF TELOMERASEGENEXPRESSION WITH SHORT INTERFERING NUCLEIC ACID (SINA)
|
|
US7935812B2
(en)
|
2002-02-20 |
2011-05-03 |
Merck Sharp & Dohme Corp. |
RNA interference mediated inhibition of hepatitis C virus (HCV) expression using short interfering nucleic acid (siNA)
|
|
WO2003106476A1
(en)
|
2002-02-20 |
2003-12-24 |
Sirna Therapeutics, Inc |
Nucleic acid mediated inhibition of enterococcus infection and cytolysin toxin activity
|
|
AU2003213005A1
(en)
|
2002-02-20 |
2003-09-09 |
Sirna Therapeutics, Inc |
RNA INTERFERENCE MEDIATED INHIBITION OF PROTEIN KINASE C ALPHA (PKC-ALPHA) GENE EXPRESSION USING SHORT INTERFERING NUCLEIC ACID (siNA)
|
|
AU2003213057A1
(en)
|
2002-02-20 |
2003-09-09 |
Ribozyme Pharmaceuticals, Incoporated |
Rna interference mediated inhibition of checkpoint kinase-1 (chk-1) gene expression using short interfering nucleic acid
|
|
EP1495041A4
(en)
|
2002-02-20 |
2006-02-01 |
Sirna Therapeutics Inc |
RNA interferon-mediated inhibition of gene expression of G72 and D-amino acid oxidase (DAAO) using short-term interfering nucleic acid (siNA)
|
|
EP1448590A4
(en)
|
2002-02-20 |
2004-12-15 |
Sirna Therapeutics Inc |
Inhibition of the myc and myb genes mediated by RNA interference mediated or genes of the corresponding synthetic pathways
|
|
JP2005517433A
(ja)
|
2002-02-20 |
2005-06-16 |
サーナ・セラピューティクス・インコーポレイテッド |
短干渉核酸（ｓｉＮＡ）を用いるＴＮＦおよびＴＮＦレセプタースーパーファミリー遺伝子発現のＲＮＡ干渉媒介性阻害
|
|
US8232383B2
(en)
|
2002-02-20 |
2012-07-31 |
Sirna Therapeutics, Inc. |
RNA interference mediated inhibition of gene expression using chemically modified short interfering nucleic acid (siNA)
|
|
AU2003207708A1
(en)
|
2002-02-20 |
2003-09-09 |
Sirna Therapeutics, Inc. |
Rna interference mediated inhibition of map kinase genes
|
|
EP1476459A4
(en)
|
2002-02-20 |
2005-05-25 |
Sirna Therapeutics Inc |
INHIBITION OF RNA INTERFERENCE-INDUCED CHROMOSOME TRANSLOCATION GENE EXPRESSION USING SHORT INTERFERING NUCLEIC ACID (SINA)
|
|
GB2397062B
(en)
|
2002-02-20 |
2005-06-15 |
Sirna Therapeutics Inc |
RNA interference mediated inhibition of hepatitis c virus (HCV) gene expression using short interfering nucleic acid (siNA)
|
|
WO2003080638A2
(en)
|
2002-03-27 |
2003-10-02 |
Aegera Therapeutics, Inc. |
Antisense iap nucleobase oligomers and uses thereof
|
|
US8101348B2
(en)
*
|
2002-07-10 |
2012-01-24 |
Max-Planck-Gesellschaft Zur Foerderung Der Wissenschaften E.V. |
RNA-interference by single-stranded RNA molecules
|
|
ES2280826T5
(es)
|
2002-08-05 |
2017-08-03 |
Silence Therapeutics Gmbh |
Nuevas formas adicionales de moléculas de ARN de interferencia
|
|
WO2004014933A1
(en)
|
2002-08-07 |
2004-02-19 |
University Of Massachusetts |
Compositions for rna interference and methods of use thereof
|
|
US20040029275A1
(en)
|
2002-08-10 |
2004-02-12 |
David Brown |
Methods and compositions for reducing target gene expression using cocktails of siRNAs or constructs expressing siRNAs
|
|
US7923547B2
(en)
|
2002-09-05 |
2011-04-12 |
Sirna Therapeutics, Inc. |
RNA interference mediated inhibition of gene expression using chemically modified short interfering nucleic acid (siNA)
|
|
US8133903B2
(en)
|
2003-10-21 |
2012-03-13 |
Los Angeles Biomedical Research Institute at Harbor—UCLA Medical Center |
Methods of use of inhibitors of phosphodiesterases and modulators of nitric oxide, reactive oxygen species, and metalloproteinases in the treatment of peyronie's disease, arteriosclerosis and other fibrotic diseases
|
|
AU2003291682A1
(en)
|
2002-11-05 |
2004-06-03 |
Isis Pharmaceuticals, Inc. |
2'-methoxy substituted oligomeric compounds and compositions for use in gene modulations
|
|
US7816337B2
(en)
|
2003-02-18 |
2010-10-19 |
Roche Madison Inc. |
Reversible attachment of a membrane active polymer to a polynucleotide
|
|
US6977223B2
(en)
|
2003-03-07 |
2005-12-20 |
Massachusetts Institute Of Technology |
Three dimensional microfabrication
|
|
WO2004090105A2
(en)
|
2003-04-02 |
2004-10-21 |
Dharmacon, Inc. |
Modified polynucleotides for use in rna interference
|
|
SG190613A1
(en)
|
2003-07-16 |
2013-06-28 |
Protiva Biotherapeutics Inc |
Lipid encapsulated interfering rna
|
|
CN1882693B
(zh)
|
2003-09-15 |
2012-08-15 |
普洛体维生物治疗公司 |
聚乙二醇修饰的脂质化合物及其应用
|
|
WO2005028650A2
(en)
|
2003-09-16 |
2005-03-31 |
Sirna Therapeutics, Inc. |
RNA INTERFERENCE MEDIATED INHIBITION OF HEPATITIS C VIRUS (HCV) EXPRESSION USING SHORT INTERFERING NUCLEIC ACID (siNA)
|
|
SG146682A1
(en)
*
|
2003-09-18 |
2008-10-30 |
Isis Pharmaceuticals Inc |
Modulation of eif4e expression
|
|
US7943179B2
(en)
|
2003-09-23 |
2011-05-17 |
Massachusetts Institute Of Technology |
pH triggerable polymeric particles
|
|
CN1918175A
(zh)
|
2003-09-29 |
2007-02-21 |
托皮根药品公司 |
治疗包括炎症状况的疾病的寡核苷酸组合物和方法
|
|
EP1675948A2
(en)
|
2003-10-23 |
2006-07-05 |
Sirna Therapeutics, Inc. |
RNA INTERFERENCE MEDIATED TREATMENT OF PARKINSON DISEASE USING SHORT INTERERING NUCLEIC ACID (siNA)
|
|
WO2005044981A2
(en)
|
2003-10-23 |
2005-05-19 |
Sirna Therapeutics, Inc. |
Rna interference mediated inhibition of gene expression using short interfering nucleic acid (sina)
|
|
CN1906308B
(zh)
|
2003-12-19 |
2011-09-14 |
诺华疫苗和诊断公司 |
小干扰rna的细胞转染制剂、相关组合物以及制备和使用方法
|
|
JP2007523649A
(ja)
|
2004-02-10 |
2007-08-23 |
サーナ・セラピューティクス・インコーポレイテッド |
多機能短鎖干渉核酸（多機能ｓｉＮＡ）を用い、ＲＮＡ干渉を介した遺伝子発現の阻害
|
|
US8790919B2
(en)
*
|
2004-03-15 |
2014-07-29 |
Isis Pharmaceuticals, Inc. |
Compositions and methods for optimizing cleavage of RNA by RNase H
|
|
CA2564616C
(en)
|
2004-04-20 |
2016-08-30 |
Nastech Pharmaceutical Company Inc. |
Methods and compositions for enhancing delivery of double-stranded rna or a double-stranded hybrid nucleic acid to regulate gene expression in mammalian cells
|
|
US20060040882A1
(en)
|
2004-05-04 |
2006-02-23 |
Lishan Chen |
Compostions and methods for enhancing delivery of nucleic acids into cells and for modifying expression of target genes in cells
|
|
ATE450251T1
(de)
|
2004-05-17 |
2009-12-15 |
Tekmira Pharmaceuticals Corp |
Liposomale formulierungen mit dihydrosphingomyelin und verfahren zu ihrer verwendung
|
|
US20060019258A1
(en)
|
2004-07-20 |
2006-01-26 |
Illumina, Inc. |
Methods and compositions for detection of small interfering RNA and micro-RNA
|
|
US20060142228A1
(en)
*
|
2004-12-23 |
2006-06-29 |
Ambion, Inc. |
Methods and compositions concerning siRNA's as mediators of RNA interference
|
|
CN101119734B
(zh)
*
|
2005-01-07 |
2012-05-09 |
阿尔尼拉姆医药品有限公司 |
RSV的RNAi调节及其治疗应用
|
|
WO2007086883A2
(en)
|
2005-02-14 |
2007-08-02 |
Sirna Therapeutics, Inc. |
Cationic lipids and formulated molecular compositions containing them
|
|
US7404969B2
(en)
|
2005-02-14 |
2008-07-29 |
Sirna Therapeutics, Inc. |
Lipid nanoparticle based compositions and methods for the delivery of biologically active molecules
|
|
US8859749B2
(en)
|
2005-03-08 |
2014-10-14 |
Qiagen Gmbh |
Modified short interfering RNA
|
|
US20070213292A1
(en)
|
2005-08-10 |
2007-09-13 |
The Rockefeller University |
Chemically modified oligonucleotides for use in modulating micro RNA and uses thereof
|
|
US20090176725A1
(en)
|
2005-08-17 |
2009-07-09 |
Sirna Therapeutics Inc. |
Chemically modified short interfering nucleic acid molecules that mediate rna interference
|
|
EP1931781B1
(en)
|
2005-08-17 |
2016-07-27 |
Sirna Therapeutics, Inc. |
Chemically modified short interfering nucleic acid molecules that mediate rna interference
|
|
BRPI0715375A2
(pt)
|
2006-08-18 |
2013-06-18 |
Hoffmann La Roche |
policonjugados para distribuiÇço in vivo de polinucleotÍdeos
|
|
WO2008109105A2
(en)
*
|
2007-03-06 |
2008-09-12 |
Flagship Ventures |
Methods and compositions for improved therapeutic effects with sirna
|
|
WO2008115387A2
(en)
*
|
2007-03-15 |
2008-09-25 |
University Hospitals Of Cleveland |
Screening, diagnosing, treating and prognosis of pathophysiologic states by rna regulation
|
|
BRPI0811170B8
(pt)
|
2007-05-22 |
2021-05-25 |
Arcturus Therapeutics Inc |
oligonucleotídeos de rna e complexos de rna substituídos por hidroximetila
|
|
EP2714904B1
(en)
*
|
2007-06-14 |
2017-04-12 |
Mirx Therapeutics ApS |
Oligonucleotides for modulation of target rna activity
|
|
CN103898110A
(zh)
*
|
2007-10-03 |
2014-07-02 |
夸克制药公司 |
新siRNA结构
|
|
CA2708171C
(en)
|
2007-12-04 |
2018-02-27 |
Alnylam Pharmaceuticals, Inc. |
Folate conjugates
|
|
CN102006890A
(zh)
|
2007-12-04 |
2011-04-06 |
阿尔尼拉姆医药品有限公司 |
靶向脂质
|
|
WO2010006237A2
(en)
|
2008-07-11 |
2010-01-14 |
Alnylam Pharmaceuticals, Inc. |
Phosphorothioate oligonucleotides non-nucleosidic phosphorothiotes as delivery agents for irna agents
|
|
JP2012502040A
(ja)
*
|
2008-09-02 |
2012-01-26 |
アルニラム ファーマスーティカルズ インコーポレイテッド |
三リン酸塩オリゴヌクレオチドの合成方法および誘導体
|
|
WO2010048585A2
(en)
|
2008-10-24 |
2010-04-29 |
Isis Pharmaceuticals, Inc. |
Oligomeric compounds and methods
|
|
MX2011008383A
(es)
*
|
2009-02-10 |
2011-09-06 |
Idera Pharmaceuticals Inc |
Agonistas basados en acido ribonucleico sintetico de receptor 7 tipo toll.
|
|
EP3424939A1
(en)
*
|
2009-03-02 |
2019-01-09 |
Alnylam Pharmaceuticals Inc. |
Nucleic acid chemical modifications
|
|
US9096850B2
(en)
*
|
2009-08-24 |
2015-08-04 |
Sirna Therapeutics, Inc. |
Segmented micro RNA mimetics
|
|
SI2470656T1
(sl)
*
|
2009-08-27 |
2015-07-31 |
Idera Pharmaceuticals, Inc. |
Sestavek za inhibicijo ekspresije genov in njegova uporaba
|
|
US10913767B2
(en)
|
2010-04-22 |
2021-02-09 |
Alnylam Pharmaceuticals, Inc. |
Oligonucleotides comprising acyclic and abasic nucleosides and analogs
|
|
WO2012027206A1
(en)
*
|
2010-08-24 |
2012-03-01 |
Merck Sharp & Dohme Corp. |
SINGLE-STRANDED RNAi AGENTS CONTAINING AN INTERNAL, NON-NUCLEIC ACID SPACER
|
|
WO2012068187A1
(en)
|
2010-11-19 |
2012-05-24 |
Merck Sharp & Dohme Corp. |
Poly(amide) polymers for the delivery of oligonucleotides
|
|
IL303831A
(en)
|
2011-11-18 |
2023-08-01 |
Alnylam Pharmaceuticals Inc |
Adapted RNAI factors
|
|
EP3358013B1
(en)
|
2012-05-02 |
2020-06-24 |
Sirna Therapeutics, Inc. |
Short interfering nucleic acid (sina) compositions
|