JP6106085B2 - 内部非核酸スペーサーを含む一本鎖RNAi剤 - Google Patents
内部非核酸スペーサーを含む一本鎖RNAi剤 Download PDFInfo
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- JP6106085B2 JP6106085B2 JP2013526032A JP2013526032A JP6106085B2 JP 6106085 B2 JP6106085 B2 JP 6106085B2 JP 2013526032 A JP2013526032 A JP 2013526032A JP 2013526032 A JP2013526032 A JP 2013526032A JP 6106085 B2 JP6106085 B2 JP 6106085B2
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- C12N2310/30—Chemical structure
- C12N2310/31—Chemical structure of the backbone
- C12N2310/318—Chemical structure of the backbone where the PO2 is completely replaced, e.g. MMI or formacetal
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- C12N2310/30—Chemical structure
- C12N2310/34—Spatial arrangement of the modifications
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- C12N2310/30—Chemical structure
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- C12N2310/3515—Lipophilic moiety, e.g. cholesterol
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- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/30—Chemical structure
- C12N2310/35—Nature of the modification
- C12N2310/351—Conjugate
- C12N2310/3519—Fusion with another nucleic acid
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Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US37647110P | 2010-08-24 | 2010-08-24 | |
| US61/376,471 | 2010-08-24 | ||
| PCT/US2011/048338 WO2012027206A1 (en) | 2010-08-24 | 2011-08-19 | SINGLE-STRANDED RNAi AGENTS CONTAINING AN INTERNAL, NON-NUCLEIC ACID SPACER |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016249699A Division JP2017079776A (ja) | 2010-08-24 | 2016-12-22 | 内部非核酸スペーサーを含む一本鎖RNAi剤 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2013535982A JP2013535982A (ja) | 2013-09-19 |
| JP6106085B2 true JP6106085B2 (ja) | 2017-03-29 |
Family
ID=45723747
Family Applications (5)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013526032A Active JP6106085B2 (ja) | 2010-08-24 | 2011-08-19 | 内部非核酸スペーサーを含む一本鎖RNAi剤 |
| JP2016249699A Pending JP2017079776A (ja) | 2010-08-24 | 2016-12-22 | 内部非核酸スペーサーを含む一本鎖RNAi剤 |
| JP2020009687A Withdrawn JP2020074788A (ja) | 2010-08-24 | 2020-01-24 | 内部非核酸スペーサーを含む一本鎖RNAi剤 |
| JP2021199768A Pending JP2022037070A (ja) | 2010-08-24 | 2021-12-09 | 内部非核酸スペーサーを含む一本鎖RNAi剤 |
| JP2023076252A Active JP7527437B2 (ja) | 2010-08-24 | 2023-05-02 | 内部非核酸スペーサーを含む一本鎖RNAi剤 |
Family Applications After (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016249699A Pending JP2017079776A (ja) | 2010-08-24 | 2016-12-22 | 内部非核酸スペーサーを含む一本鎖RNAi剤 |
| JP2020009687A Withdrawn JP2020074788A (ja) | 2010-08-24 | 2020-01-24 | 内部非核酸スペーサーを含む一本鎖RNAi剤 |
| JP2021199768A Pending JP2022037070A (ja) | 2010-08-24 | 2021-12-09 | 内部非核酸スペーサーを含む一本鎖RNAi剤 |
| JP2023076252A Active JP7527437B2 (ja) | 2010-08-24 | 2023-05-02 | 内部非核酸スペーサーを含む一本鎖RNAi剤 |
Country Status (6)
| Country | Link |
|---|---|
| US (3) | US9243246B2 (enExample) |
| EP (2) | EP3372684B1 (enExample) |
| JP (5) | JP6106085B2 (enExample) |
| KR (1) | KR20130137160A (enExample) |
| CN (1) | CN103140582A (enExample) |
| WO (1) | WO2012027206A1 (enExample) |
Families Citing this family (40)
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| US9657294B2 (en) | 2002-02-20 | 2017-05-23 | Sirna Therapeutics, Inc. | RNA interference mediated inhibition of gene expression using chemically modified short interfering nucleic acid (siNA) |
| US9181551B2 (en) | 2002-02-20 | 2015-11-10 | Sirna Therapeutics, Inc. | RNA interference mediated inhibition of gene expression using chemically modified short interfering nucleic acid (siNA) |
| US8748405B2 (en) | 2007-01-26 | 2014-06-10 | City Of Hope | Methods and compositions for the treatment of cancer or other diseases |
| US9096850B2 (en) | 2009-08-24 | 2015-08-04 | Sirna Therapeutics, Inc. | Segmented micro RNA mimetics |
| US9243246B2 (en) * | 2010-08-24 | 2016-01-26 | Sirna Therapeutics, Inc. | Single-stranded RNAi agents containing an internal, non-nucleic acid spacer |
| DK2632472T3 (en) | 2010-10-29 | 2018-03-19 | Sirna Therapeutics Inc | RNA INTERFERENCE-MEDIATED INHIBITION OF GENE EXPRESSION USING SHORT INTERFERRING NUCLEIC ACIDS (SINA) |
| EP2652151A2 (en) | 2010-12-15 | 2013-10-23 | Miragen Therapeutics | Microrna inhibitors comprising locked nucleotides |
| KR20140091688A (ko) | 2011-10-06 | 2014-07-22 | 미라젠 세러퓨틱스 인코포레이티드 | 마이크로rna 조절에 의한 전신 에너지 항상성의 제어 |
| US20150299696A1 (en) * | 2012-05-02 | 2015-10-22 | Sirna Therapeutics, Inc. | SHORT INTERFERING NUCLEIC ACID (siNA) COMPOSITIONS |
| US9334498B2 (en) | 2012-05-10 | 2016-05-10 | Uab Research Foundation | Methods and compositions for modulating MIR-204 activity |
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| KR101696704B1 (ko) * | 2013-12-17 | 2017-01-16 | 주식회사 인코드젠 | 오프-타겟을 막기 위해 변형된 rna 간섭 유도 핵산 및 그 용도 |
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| CN103924002B (zh) * | 2014-05-04 | 2016-01-20 | 山东大学 | 血清中的microRNA作为肝癌诊断标志物的应用 |
| KR102557689B1 (ko) | 2014-06-12 | 2023-07-20 | 국립연구개발법인 고쿠리츠간켄큐센터 | 전립선암 검출 키트 또는 디바이스 및 검출 방법 |
| CN107636003A (zh) | 2015-01-20 | 2018-01-26 | 米拉根医疗股份有限公司 | miR‑92抑制剂及其用途 |
| WO2017029556A1 (en) | 2015-08-20 | 2017-02-23 | Asociación Centro De Investigación Cooperativa En Biociencias - Cis Biogune | Methods and compositions to treat liver diseases and conditions |
| TWI685500B (zh) * | 2015-10-13 | 2020-02-21 | 長庚大學 | 以微核酸-520b(miR-520b)序列作爲抑制頭頸癌腫瘤生長、侵犯與轉移及其醫藥組成物之用途 |
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| US11597744B2 (en) | 2017-06-30 | 2023-03-07 | Sirius Therapeutics, Inc. | Chiral phosphoramidite auxiliaries and methods of their use |
| KR102193874B1 (ko) * | 2018-05-31 | 2020-12-23 | 고려대학교 산학협력단 | 마이크로rna를 억제하는 변형 핵산 및 이의 용도 |
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- 2011-08-19 EP EP18000072.1A patent/EP3372684B1/en active Active
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| JP2022037070A (ja) | 2022-03-08 |
| JP2023100832A (ja) | 2023-07-19 |
| EP2609198A1 (en) | 2013-07-03 |
| US9845466B2 (en) | 2017-12-19 |
| EP3372684A1 (en) | 2018-09-12 |
| US9243246B2 (en) | 2016-01-26 |
| EP3372684B1 (en) | 2020-10-07 |
| CN103140582A (zh) | 2013-06-05 |
| US20180080024A1 (en) | 2018-03-22 |
| US10584335B2 (en) | 2020-03-10 |
| JP2020074788A (ja) | 2020-05-21 |
| JP2017079776A (ja) | 2017-05-18 |
| WO2012027206A1 (en) | 2012-03-01 |
| JP2013535982A (ja) | 2013-09-19 |
| EP2609198A4 (en) | 2014-11-19 |
| KR20130137160A (ko) | 2013-12-16 |
| US20160222381A1 (en) | 2016-08-04 |
| US20130171242A1 (en) | 2013-07-04 |
| EP2609198B8 (en) | 2018-03-28 |
| JP7527437B2 (ja) | 2024-08-02 |
| EP2609198B1 (en) | 2018-02-21 |
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