CN103140582A - 含有内部非核酸间隔子的单链RNAi试剂 - Google Patents

含有内部非核酸间隔子的单链RNAi试剂 Download PDF

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CN103140582A
CN103140582A CN2011800473832A CN201180047383A CN103140582A CN 103140582 A CN103140582 A CN 103140582A CN 2011800473832 A CN2011800473832 A CN 2011800473832A CN 201180047383 A CN201180047383 A CN 201180047383A CN 103140582 A CN103140582 A CN 103140582A
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nucleotide
molecule
nucleotides
nucleic acid
stranded
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L.林
A.威林汉
L.赵
G.肖恩
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Merck Sharp and Dohme LLC
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CN2011800473832A 2010-08-24 2011-08-19 含有内部非核酸间隔子的单链RNAi试剂 Pending CN103140582A (zh)

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US37647110P 2010-08-24 2010-08-24
US61/376,471 2010-08-24
PCT/US2011/048338 WO2012027206A1 (en) 2010-08-24 2011-08-19 SINGLE-STRANDED RNAi AGENTS CONTAINING AN INTERNAL, NON-NUCLEIC ACID SPACER

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US (3) US9243246B2 (enExample)
EP (2) EP2609198B8 (enExample)
JP (5) JP6106085B2 (enExample)
KR (1) KR20130137160A (enExample)
CN (1) CN103140582A (enExample)
WO (1) WO2012027206A1 (enExample)

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CN105792832A (zh) * 2013-10-04 2016-07-20 诺华股份有限公司 用于治疗乙肝病毒的有机化合物
CN105829535A (zh) * 2013-12-17 2016-08-03 英科德甘公司 用于阻止脱靶效应而变形的rna干扰诱导核酸及其用途
CN105861728A (zh) * 2016-06-12 2016-08-17 上海市第十人民医院 循环miRNA作为年龄相关黄斑变性诊断标志物中的应用
CN109706239A (zh) * 2018-09-26 2019-05-03 南京市妇幼保健院 一种miR-1976在防治细菌性阴道病中的应用
TWI685500B (zh) * 2015-10-13 2020-02-21 長庚大學 以微核酸-５２０ｂ（ｍｉＲ-５２０ｂ）序列作爲抑制頭頸癌腫瘤生長、侵犯與轉移及其醫藥組成物之用途

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JP6694811B2 (ja) 2013-10-04 2020-05-20 ノバルティス アーゲー ＲＮＡ干渉に使用するためのＲＮＡｉ剤用の３’末端キャップ
CN104560992B (zh) * 2013-10-10 2018-01-02 复旦大学附属妇产科医院 一种用于预防和治疗人乳头瘤病毒感染和宫颈癌的微小rna
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CN103924002B (zh) * 2014-05-04 2016-01-20 山东大学 血清中的microRNA作为肝癌诊断标志物的应用
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KR102193874B1 (ko) * 2018-05-31 2020-12-23 고려대학교 산학협력단 마이크로rna를 억제하는 변형 핵산 및 이의 용도
WO2020032228A1 (ja) 2018-08-10 2020-02-13 東レ株式会社 前立腺がんの検出のためのキット、デバイス及び方法
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CN105792832B (zh) * 2013-10-04 2021-03-23 诺华股份有限公司 用于治疗乙肝病毒的有机化合物
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