KR20170093988A - Gst-pi 유전자 조정을 위한 rna 제제 - Google Patents
Gst-pi 유전자 조정을 위한 rna 제제 Download PDFInfo
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- KR20170093988A KR20170093988A KR1020177020901A KR20177020901A KR20170093988A KR 20170093988 A KR20170093988 A KR 20170093988A KR 1020177020901 A KR1020177020901 A KR 1020177020901A KR 20177020901 A KR20177020901 A KR 20177020901A KR 20170093988 A KR20170093988 A KR 20170093988A
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Abstract
본 발명은 RNA 간섭을 사용하는 인간 GST-π 의 발현을 조정하기 위한 화합물, 조성물 및 방법을 제공한다. RNA 간섭 분자는 악성 종양과 같은 질환을 예방 또는 치료하기 위한 방법에서 사용될 수 있다. 핵산 분자는 a) 폴리뉴클레오티드 센스 가닥 및 폴리뉴클레오티드 안티센스 가닥을 가질 수 있고; b) 분자의 각각의 가닥은 15 내지 30 개 뉴클레오티드 길이이고; c) 안티센스 가닥의 15 내지 30 개 뉴클레오티드의 인접 영역은 GST-π 를 인코딩하는 mRNA 의 서열에 상보적이고; d) 센스 가닥의 적어도 일부는 안티센스 가닥의 적어도 일부에 상보적일 수 있고, 분자는 15 내지 30 개 뉴클레오티드 길이의 듀플렉스 영역을 갖는다.
Description
발명의 기술 분야
본 발명은 핵산 기반 분자로 구성되는 생물의약품 및 치료제의 분야와 관련된다. 더 상세하게는, 본 발명은 인간 GST-π 의 발현을 조정하기 위해 RNA 간섭 (RNA interference) (RNAi) 을 이용하는 화합물 및 조성물과 관련된다.
서열목록
본 출원은 2015 년 12 월 23 일에 생성된 ASCII 파일로서 전자적으로 제출되는 파일명이 ND5123202WO_SL.txt 인 서열 목록을 포함하고, 그 크기는 442,955 바이트이고, 여기에 그 전체가 참조로서 인용된다.
다양한 인간 암 조직은 돌연변이된 KRAS 유전자의 출현과 상관관계가 있는 것으로 밝혀졌다. 일부 경우, 조직은 또한 상승된 수준의 글루타티온 S-트랜스퍼라제 Pi (Glutathione S-Tranferase Pi) (GST-π) 발현을 나타낸다. (Miyanishi et al., Gastroenterology, 2001, Vol. 121:865-874, Abstract) 예를 들어, 상승된 혈청 GST-π 수준이 다양한 위장 악성종양을 가진 환자에서 관찰되었다. (Niitsu et al., Cancer, 1989, Vol.63, No. 2, pp. 317-323, Abstract)
GST-π 는 소수성 및 친전자성 화합물과 환원된 글루타티온과의 콘쥬게이션을 촉매작용함으로써 해독에 역할을 하는 효소의 GST 패밀리의 구성원이다. GST-π 발현은 siRNA 로 시험관 내에서 감소될 수 있다. (Niitsu et al., US 2014/0315975 A1)
GST-π 발현의 억제를 위한 치료학은 고도로 강력한 siRNA 서열 및 구조를 필요로 할 것이다.
필요한 것은 GST-π 발현의 억제를 위한 siRNA 서열, 화합물 및 구조이다.
본 발명은 RNA 간섭을 사용하여 인간 GST-π 의 발현을 조정하기 위한 화합물, 조성물 및 방법에 관한 것이다.
일부 구현예에서, 본 발명은 GST-π 의 RNA 간섭 유전자 침묵화 (gene silencing) 를 위한 분자를 제공한다.
추가의 구현예에서, 본 발명의 구조, 분자 및 조성물은 질환을 예방 또는 치료하기 위한, 또는 악성 종양을 포함하는, GST-π 와 연관된 조건 또는 장애의 증상을 경감하기 위한 방법에서 사용될 수 있다.
본 발명의 구현예는 하기를 포함한다:
하기와 같은 핵산 분자:
a) 분자는 폴리뉴클레오티드 센스 가닥 및 폴리뉴클레오티드 안티센스 가닥을 가짐;
b) 분자의 각각의 가닥은 15 내지 30 개 뉴클레오티드 길이임;
c) 안티센스 가닥의 15 내지 30 의 뉴클레오티드의 인접 영역은 GST-π 를 인코딩하는 mRNA 의 서열과 상보적임;
d) 센스 가닥의 적어도 일부는 안티센스 가닥의 적어도 일부에 상보적이고, 상기 분자는 15 내지 30 개 뉴클레오티드 길이의 듀플렉스 영역을 가짐.
일부 구현예에서, 핵산 분자는 분자의 듀플렉스 영역 내에 위치하는 GST-π 를 인코딩하는 mRNA 의 서열에 상보적인 안티센스 가닥의 15 내지 30 개 뉴클레오티드의 인접 영역을 가질 수 있다.
부가적인 구현예에서, 핵산 분자는 GST-π 를 인코딩하는 mRNA 의 서열에 상보적인 안티센스 가닥의 15 내지 30 개 뉴클레오티드의 인접 영역을 가질 수 있다.
본 발명의 화합물은 SEQ ID NO:1 의 5'UTR 위치 1 내지 249, SEQ ID NO:1 의 CDS 위치 250 내지 882, 및 SEQ ID NO:1 의 3'UTR 위치 883 내지 986 으로 이루어지는 군으로부터 선택되는 GST-π 를 인코딩하는 mRNA 의 서열을 가질 수 있다.
특정 구현예에서, 핵산 분자의 각각의 가닥은 18 내지 22 개 뉴클레오티드 길이일 수 있다. 핵산 분자의 듀플렉스 영역은 19 개 뉴클레오티드 길이일 수 있다.
대안적인 형태에서, 핵산 분자는 단일 가닥으로서 연결된 폴리뉴클레오티드 센스 가닥 및 폴리뉴클레오티드 안티센스 가닥을 가질 수 있고, 루프에 의해 하나의 말단에 연결된 듀플렉스 영역을 형성한다.
본 설명의 핵산 분자의 일부 구현예는 블런트 말단을 가질 수 있다. 특정 구현예에서, 핵산 분자는 하나 이상의 3' 오버행 (overhang) 을 가질 수 있다.
본 발명은 유전자 침묵화를 위해 활성인 RNAi 분자인 다양한 핵산 분자를 제공한다. 본 발명의 핵산 분자는 유전자 침묵화를 위해 활성인 dsRNA, siRNA, 마이크로-RNA, 또는 shRNA, 뿐 아니라 DNA-지정 RNA (ddRNA), Piwi-상호작용 RNA (piRNA), 또는 반복 연관 siRNA (rasiRNA) 일 수 있다. 핵산 분자는 GST-π 의 발현 억제를 위해 활성일 수 있다.
본 발명의 구현예는 추가로 100 pM 미만의 GST-π 의 녹다운 (knockdown) 을 위한 IC50 을 갖는 핵산 분자를 제공한다.
본 발명은 추가로 본 발명의 핵산 분자 중 하나 이상을, 약학적으로 허용가능한 담체와 함께 함유하는 조성물을 고려한다. 특정 구현예에서, 담체는 지질 분자 또는 리포좀일 수 있다.
본 발명의 화합물 및 조성물은 화합물 또는 조성물을 이를 필요로 하는 대상체에게 투여함으로써, GST-π 관련 질환을 예방 또는 치료하기 위한 방법에서 유용하다.
본 발명의 방법은 악성 종양을 예방 또는 치료하기 위해 본 발명의 화합물을 이용할 수 있다. 악성 종양은 다양한 질환, 예를 들어, GST-π 발현과 연관된 암, 돌연변이된 KRAS 를 발현하는 세포에 의해 야기되는 암, 육종, 섬유육종, 악성 섬유 조직구종, 지방육종, 횡문근육종, 평활근육종, 혈관육종, 카포시 육종, 림프관 육종, 활액막 육종, 연골육종, 골육종, 암종, 뇌종양, 두경부암, 유방암, 폐암, 식도암, 위암, 십이지장암, 맹장암, 결장직장암, 직장암, 간암, 췌장암, 담낭암, 담관암, 항문암, 신장암, 요도암, 방광암, 전립선암, 고환암, 자궁암, 난소암, 피부암, 백혈병, 악성 림프종, 상피성 악성 종양, 및 비-상피성 악성 종양에 존재할 수 있다.
도 1: 도 1 은 SEQ ID NO: 1 을 보여주며, 이것은 986 개 뉴클레오티드 길이인, GenBank 수탁 번호 NM_000852.3 (hGSTP1) 에 기재된, 표적 인간 글루타티온 S -트랜스페라아제 pi (인간 GST-π) mRNA 의 핵산 서열이다.
도 2: 도 2 는 GST-π siRNA 에 대한 생체 내 녹다운 효력을 보여준다. GST-π mRNA 의 용량 의존적 녹다운을 도 2 에 제시된 바와 같이, GST-π 에 표적한 siRNA 와 함께 생체 내에서 관찰하였다.
도 3: 도 3 은 GST-π siRNA 에 의한 증식의 억제를 보여준다. 증식의 투여량-의존적 억제를 도 3 에 제시된 바와 같이, GST-π 에 표적한 siRNA 와 함께 시험관 내에서 A549 세포주에서 관찰하였다.
도 4: 도 4 는 GST-π siRNA 에 대한 종양 억제 효과를 보여준다. 췌장암 이종이식 모델은 GST-π 에 표적한 siRNA 의 0.75 mg/kg 에서 비교적 낮은 투여량으로 이용하였다. GST-π siRNA 는 유효한 종양 억제 효과를 입증하였다.
도 2: 도 2 는 GST-π siRNA 에 대한 생체 내 녹다운 효력을 보여준다. GST-π mRNA 의 용량 의존적 녹다운을 도 2 에 제시된 바와 같이, GST-π 에 표적한 siRNA 와 함께 생체 내에서 관찰하였다.
도 3: 도 3 은 GST-π siRNA 에 의한 증식의 억제를 보여준다. 증식의 투여량-의존적 억제를 도 3 에 제시된 바와 같이, GST-π 에 표적한 siRNA 와 함께 시험관 내에서 A549 세포주에서 관찰하였다.
도 4: 도 4 는 GST-π siRNA 에 대한 종양 억제 효과를 보여준다. 췌장암 이종이식 모델은 GST-π 에 표적한 siRNA 의 0.75 mg/kg 에서 비교적 낮은 투여량으로 이용하였다. GST-π siRNA 는 유효한 종양 억제 효과를 입증하였다.
본 발명은 GST-π 의 발현을 조정하기 위한 핵산 기반의 치료법을 위한 화합물, 조성물 및 방법에 관한 것이다.
일부 구현예에서, 본 발명은 RNA 간섭에 활성인 분자 뿐 아니라, GST-π 의 발현을 침묵시킬 수 있는 구조 및 조성물을 제공한다.
본 발명의 구조 및 조성물은 악성 종양과 같은 다양한 질환을 예방 또는 치료하는데 사용될 수 있다.
추가의 구현예에서, 본 발명은 본 발명의 하나 이상의 치료적 RNAi 분자의 전달 및 섭취를 위한 조성물 뿐 아니라 이의 사용 방법을 제공한다. 본 발명의 RNA-기반 조성물은 암과 같은 악성 종양을 예방 또는 치료하기 위한 방법에서 사용될 수 있다.
본 발명의 치료 조성물은 RNA 간섭에 활성인 핵산 분자를 포함한다. 치료 핵산 분자는 유전자 침묵화를 위해 GSTP1 (GST-π) 에 표적될 수 있다.
다양한 구현예에서, 본 발명은 소형 간섭 RNA (siRNA) 로서 활성일 수 있고, GST-π 유전자 발현을 조절 또는 침묵시킬 수 있는 다양한 분자를 제공한다.
본 발명의 siRNA 는 악성 종양을 예방 또는 치료하기 위해 사용될 수 있다.
본 발명의 구현예는 추가로 악성 종양의 예방 또는 치료를 필요로 하는 대상체에 대한 본 발명의 siRNA 의 전달을 위한 비히클, 제형, 또는 지질 나노입자 제형을 제공한다. 본 발명은 추가로 포유동물에게 치료제로서 siRNA 를 투여하기 위한 방법을 고려한다.
본 발명의 치료 분자 및 조성물은 화합물 또는 조성물을 이를 필요로 하는 대상체에게 투여함으로써, GST-π 관련 질환을 예방 또는 치료하기 위해 RNA 간섭에 사용될 수 있다.
본 발명의 방법은 악성 종양을 예방 또는 치료하기 위해 본 발명의 화합물을 이용할 수 있다. 악성 종양은 다양한 질환, 예를 들어, GST-π 를 고도로 발현하는 암, 돌연변이된 KRAS 를 발현하는 세포에 의해 야기된 암, 육종, 섬유육종, 악성 섬유 조직구종, 지방육종, 횡문근육종, 평활근육종, 혈관육종, 카포시 육종, 림프관 육종, 활액막 육종, 연골육종, 골육종, 암종, 뇌종양, 두경부암, 유방암, 폐암, 식도암, 위암, 십이지장암, 결장직장암, 간암, 췌장암, 담낭암, 담관암, 신장암, 요도암, 방광암, 전립선암, 고환암, 자궁암, 난소암, 피부암, 백혈병, 악성 림프종, 상피성 악성 종양, 및 비-상피성 악성 종양에 존재할 수 있다.
특정 구현예에서, 본 발명의 치료 분자의 조합은 GST-π 유전자 발현의 침묵화 또는 억제에 사용될 수 있다.
본 발명은 다양한 RNAi 분자를 제공하며, 여기에서 각 분자는 폴리뉴클레오티드 센스 가닥 및 폴리뉴클레오티드 안티센스 가닥을 갖고; 분자의 각 가닥은 15 내지 30 개 뉴클레오티드 길이를 갖고; 안티센스 가닥의 15 내지 30 개 뉴클레오티드의 인접 영역 (contiguous region) 은 GST-π 를 인코딩하는 mRNA 의 서열에 상보적이고; 센스 가닥의 적어도 일부분은 안티센스 가닥의 적어도 일부분에 상보적이고, 분자는 15 내지 30 개 뉴클레오티드 길이의 듀플렉스 영역을 갖는다.
본 발명의 RNAi 분자는 분자의 듀플렉스 영역에 위치하는, GST-π 를 인코딩하는 mRNA 의 서열에 상보적인 안티센스 가닥의 15 내지 30 개 뉴클레오티드의 인접 영역을 가질 수 있다.
일부 구현예에서, RNAi 분자는 GST-π 를 인코딩하는 mRNA 의 서열에 상보적인 안티센스 가닥의 15 내지 30 개 뉴클레오티드의 인접 영역을 가질 수 있다.
본 발명의 구현예는 또한 이를 필요로 하는 포유동물에서 악성 종양의 하나 이상의 증상의 예방, 치료 또는 완화, 또는 악성 종양을 발달시킬 위험의 감소, 또는 악성 종양의 개시의 지연을 위한 방법을 제공할 수 있다.
GST-π 및 RNAi 분자
도 1 은 GenBank 수탁 번호 NM_000852.3 (hGSTP1) 에 기재되고, 986 개 뉴클레오티드 길이인 (SEQ ID NO: 1), 예시 표적 인간 글루타티온 S-트랜스페라아제 pi (인간 GST-π) mRNA 의 핵산 서열을 나타낸다.
당업자는 보고된 서열이 시간의 흐름에 따라 변화할 수 있고 본원에서 핵산 분자에 필요한 임의의 변화를 그에 맞춰 포함할 수 있다는 것을 이해할 것이다.
본 발명의 구현예는 작은 핵산 분자를 사용하는 GST-π 발현의 유전자 침묵화를 위한 조성물 및 방법을 제공할 수 있다. 핵산 분자의 예는 RNA 간섭에서 활성인 분자 (RNAi 분자), 짧은 간섭하는 RNA (siRNA), 이중-가닥 RNA (dsRNA), 마이크로-RNA (miRNA), 및 짧은 헤어핀 RNA (shRNA) 분자, 뿐만 아니라 DNA-지향되는 RNA (ddRNA), Piwi-상호작용 RNA (piRNA), 및 리피트 (repeat) 연합된 siRNA (rasiRNA) 를 포함한다. 이러한 분자들은 GST-π 유전자 발현에 대한 RNA 간섭을 매개할 수 있다.
본원에서 개시된 조성물 및 방법은 또한 대상체에서 다양한 종류의 악성 종양을 치료하는데 사용될 수 있다.
본 발명의 핵산 분자 및 방법은 GST-π 를 인코딩하는 유전자의 발현을 하향 조절하는데 사용될 수 있다.
본 발명의 조성물 및 방법은 GST-π 단백질 및/또는 GST-π 단백질을 인코딩하는 유전자, GST-π 와 관련되는 질환, 병태 또는 장애, 예컨대 악성 종양의 유지 및/또는 발달과 관련되는 단백질 및/또는 GST-π 를 인코딩하는 유전자의 발현을, 독립적으로 또는 조합으로, 조정 또는 조절할 수 있는 하나 이상의 핵산 분자를 포함할 수 있다.
본 발명의 조성물 및 방법은 GST-π 의 예시적인 서열과 관련하여 기재된다. 당업자는 본 발명의 다양한 양상 및 구현예가 임의의 관련된 GST-π 유전자, 서열, 또는 변이체, 예컨대 동족체 유전자 및 전사체 변이체, 및, 임의의 GST-π 유전자와 관련된 단일 뉴클레오티드 다형성 (SNP) 을 포함하는, 다형성에 관한 것이라는 점을 이해할 것이다.
일부 구현예에서, 본 발명의 조성물 및 방법은 GST-π 유전자, 예를 들어 인간 GST-π 의 발현을 하향조절하는 이중-가닥 짧은 간섭하는 핵산 (siRNA) 분자를 제공할 수 있다.
본 발명의 RNAi 분자는 GST-π 및 임의의 상동성 서열을, 예를 들어, 상보적 서열을 사용하여 또는 추가의 표적 서열을 제공할 수 있는 비-표준적 (non-canonical) 염기쌍, 예를 들어, 미스매치 (mismatch) 및/또는 워블 (wobble) 염기쌍을 편입시킴으로써, 표적으로 삼을 수 있다.
미스매치가 확인되는 경우에, 비-표준적 염기쌍, 예를 들어, 미스매치 및/또는 워블 염기가 사용되어 하나 초과의 유전자 서열을 표적으로 삼는 핵산 분자를 생성할 수 있다.
예를 들어, 비-표준적 염기쌍 예컨대 UU 및 CC 염기쌍이 사용되어 서열 상동성을 공유하는 상이한 GST-π 표적에 관한 서열을 표적화할 수 있는 핵산 분자를 생성할 수 있다. 따라서, RNAi 분자는 상동성 유전자 사이에 보존되어 있는 뉴클레오티드 서열을 표적으로 삼을 수 있고, 단일 RNAi 분자가 사용되어 하나 초과의 유전자의 발현을 억제할 수 있다.
일부 양상에서, 본 발명의 조성물 및 방법은 GST-π mRNA 에 대해 활성인 RNAi 분자를 포함하며, 여기에서 RNAi 분자는 GST-π 서열을 인코딩하는 임의의 mRNA 에 상보적인 서열을 포함한다.
일부 구현예에서, 본 공개의 RNAi 분자는 GST-π RNA 에 대한 활성을 가질 수 있으며, 여기에서 RNAi 분자는 변이체 GST-π 인코딩 서열을 갖는 RNA, 예를 들어, 악성 종양과 관련되는 것으로 당업계에 알려진 돌연변이체 GST-π 유전자에 상보적인 서열을 포함한다.
추가 구현예에서, 본 발명의 RNAi 분자는 GST-π 유전자의 뉴클레오티드 서열과 상호작용하고 GST-π 유전자 발현의 침묵화를 매개할 수 있는 뉴클레오티드 서열을 포함할 수 있다.
GST-π mRNA 를 표적으로 삼는 본 발명의 RNAi 분자의 예가 표 1 및 2 에서 보여진다.
표 1: GST-π 에 관한 RNAi 분자 서열
표 1 에 관한 기호설명: 대문자 A, G, C 및 U 는 각각 리보-A, 리보-G, 리보-C 및 리보-U 를 지칭한다. 소문자 a, g, c, t 는 각각 2'-데옥시-A, 2'-데옥시-G, 2'-데옥시-C 및 티미딘을 지칭한다.
표 2: GST-π 에 관한 RNAi 분자 서열
표 2 에 관한 기호설명: 대문자 A, G, C 및 U 는 각각 리보-A, 리보-G, 리보-C 및 리보-U 를 지칭한다. 소문자 a, g, c, t 는 각각 2'-데옥시-A, 2'-데옥시-G, 2'-데옥시-C 및 티미딘을 지칭한다.
예를 들어, 본 발명의 siRNA 는 SEQ ID NO:1341 인 안티센스 가닥, 및 SEQ ID NO:1276 인 센스 가닥, 또는 이의 화학적으로 개질된 가닥을 가질 수 있다.
예를 들어, 본 발명의 siRNA 는 SEQ ID NO:1305 인 안티센스 가닥, 및 SEQ ID NO:1240 인 센스 가닥, 또는 이의 화학적으로 개질된 가닥을 가질 수 있다.
화학적 개질은 가닥 내의 임의의 위치 중의 임의의 뉴클레오티드 상에 2'-OMe 치환기, 뿐 아니라 당업계에 공지된 다른 개질을 포함할 수 있다.
GST-π 를 조정하고 악성 종양을 치료하기 위한 방법
본 발명의 구현예는 GST-π 및/또는 GST-π 단백질의 발현을 하향 조절 또는 억제하는데 사용될 수 있는 RNAi 분자를 제공할 수 있다.
일부 구현예에서, 본 발명의 RNAi 분자는 악성 종양과 같은 질환 또는 병태와 관련될 수 있는 GST-π 일배체형 다형성으로부터 비롯되는 GST-π 및/또는 GST-π 단백질의 발현을 하향 조절 또는 억제하는데 사용될 수 있다.
GST-π 단백질 또는 mRNA 수준의 모니터링을 사용하여 유전자 침묵화를 특성규명하고, 본 발명의 화합물 및 조성물의 효능을 확인할 수 있다.
본 공개의 RNAi 분자는 개별적으로, 또는 다른 siRNA 와의 조합으로 하나 이상의 유전자의 발현을 조정하기 위해 사용될 수 있다.
본 공개의 RNAi 분자는 개별적으로, 또는 조합으로, 또는 다른 알려진 약물과 함께 악성 종양을 포함하는 GST-π 와 관련되는 질환의 예방 또는 치료 또는 병태 또는 장애의 증상의 완화를 위해 사용될 수 있다.
본 발명의 RNAi 분자는 GST-π 의 발현을 서열-특이적 방식으로 조정 또는 억제하는데 사용될 수 있다.
본 공개의 RNAi 분자는 가이드 가닥 (guide strand) 을 포함할 수 있으며, 가이드 가닥의 일련의 인접 뉴클레오티드는 GST-π mRNA 에 적어도 부분적으로 상보적이다.
특정 양상에서, 악성 종양은 본 발명의 RNAi 분자를 사용하여 RNA 간섭에 의해 치료될 수 있다.
악성 종양의 치료는 적합한 세포 기반 모델, 뿐만 아니라 생체외 또는 생체내 동물 모델에서 특성규명될 수 있다.
악성 종양의 치료는 병든 조직의 세포에서의 GST-π mRNA 의 수준 또는 GST-π 단백질의 수준을 확인함으로써 특성규명될 수 있다.
악성 종양의 치료는 병든 장기 또는 조직의 비-침습적 의료 스캐닝에 의해 특성규명될 수 있다.
본 발명의 구현예는 그것을 필요로 하는 대상체에서 GST-π 관련되는 질환 또는 병태의 증상을 예방, 치료, 또는 완화하는 방법을 포함할 수 있다.
일부 구현예에서, 대상체에서 악성 종양의 증상을 예방, 치료, 또는 완화하는 방법은 대상체에게 본 발명의 RNAi 분자를 투여하여 대상체 또는 유기체에서 GST-π 유전자의 발현을 조정하는 것을 포함할 수 있다.
일부 구현예에서, 본 발명은 세포 또는 유기체를 본 발명의 RNAi 분자와 접촉시킴으로써 세포 또는 유기체에서 GST-π 유전자의 발현을 하향 조절하는 방법을 고려한다.
RNA 간섭
RNA 간섭 (RNA Interference) (RNAi) 은 짧은 간섭하는 RNA (siRNA) 에 의해 매개되는 동물에서의 서열-특징적 전사후 유전자 침묵화를 지칭한다. 예를 들어, Zamore et al., Cell, 2000, Vol. 101, pp. 25-33; Fire et al., Nature, 1998, Vol. 391, pp. 806811; Sharp, Genes & Development, 1999, Vol. 13, pp. 139-141 을 참고한다.
세포에서의 RNAi 반응은 이중가닥 RNA (dsRNA) 에 의해 유발될 수 있지만, 그 메카니즘은 아직 완전히 이해되지 않고 있다. 세포에서의 특정 dsRNA 는 다이서 (Dicer) 효소, 리보뉴클레아제 III 효소의 작용을 받을 수 있다. 예를 들어, Zamore et al., Cell, 2000, Vol. 101, pp. 25-33; Hammond et al., Nature, 2000, Vol. 404, pp. 293-296 을 참고한다. 다이서는 dsRNA 를 dsRNA 의 더 짧은 조각인 siRNA 로 가공할 수 있다.
일반적으로, siRNA 는 약 21 내지 약 23 개 뉴클레오티드 길이일 수 있고, 약 19 개 뉴클레오티드 길이의 염기쌍 듀플렉스 영역을 포함할 수 있다.
RNAi 은 RNA 유도되는 침묵화 복합체 (RNA induced silencing complex) (RISC) 로서 알려진 엔도뉴클레아제 복합체를 수반한다. siRNA 는 RISC 복합체에 진입하여 siRNA 듀플렉스의 안티센스 가닥에 상보적인 서열을 갖는 단일가닥 RNA 표적의 절단을 매개하는 안티센스 또는 가이드 가닥을 갖는다. siRNA 의 다른 가닥은 패신저 가닥 (passenger strand) 이다. 표적 RNA 의 절단은 siRNA 듀플렉스의 안티센스 가닥에 상보적인 영역의 중간에서 일어난다. 예를 들어, Elbashir et al., Genes & Development, 2001, Vol. 15, pp. 188-200 을 참고한다.
본원에서 사용되는 바와 같이, 용어 "센스 가닥" 은 siRNA 분자의 대응하는 안티센스 가닥의 적어도 일부분에 부분적으로 또는 전체적으로 상보적인 siRNA 분자의 뉴클레오티드 서열을 지칭한다. siRNA 분자의 센스 가닥은 표적 핵산 서열과 상동성을 갖는 핵산 서열을 포함할 수 있다.
본원에서 사용되는 바와 같이, 용어 "안티센스 가닥" 은 표적 핵산 서열의 적어도 일부분에 부분적으로 또는 전체적으로 상보적인 siRNA 분자의 뉴클레오티드 서열을 지칭한다. siRNA 분자의 안티센스 가닥은 siRNA 분자의 대응하는 센스 가닥의 적어도 일부분에 상보적인 핵산 서열을 포함할 수 있다.
RNAi 분자는 RNA 간섭을 서열-특이적 방식으로 매개함으로써 유전자 발현을 하향 조절 또는 녹다운할 수 있다. 예를 들어, Zamore et al., Cell, 2000, Vol. 101, pp. 25-33; Elbashir et al., Nature, 2001, Vol. 411, pp. 494-498; Kreutzer et al., WO2000/044895; Zernicka-Goetz et al., WO2001/36646; Fire et al., WO1999/032619; Plaetinck et al., WO2000/01846; Mello et al., WO2001/029058 을 참고한다.
본원에서 사용되는 바와 같이, 유전자 발현에 관한 용어들 "억제," "하향-조절," 또는 "감소" 는 유전자의 발현, 또는 하나 이상의 단백질을 인코딩하는 mRNA 분자의 수준, 또는 인코딩된 단백질 중 하나 이상의 활성이 본 발명의 RNAi 분자 또는 siRNA 의 부재시에 관찰되는 것보다 아래로 감소되는 것을 의미한다. 예를 들어, 발현의 수준, mRNA 의 수준, 또는 인코딩된 단백질 활성의 수준은 본 발명의 RNAi 분자 또는 siRNA 의 부재시에 관찰되는 것보다 적어도 1%, 또는 적어도 10%, 또는 적어도 20%, 또는 적어도 50%, 또는 적어도 90%, 또는 그 이상 만큼 감소될 수 있다.
RNAi 분자는 또한 바이러스 유전자 발현을 녹다운하고, 그에 따라 바이러스 복제에 영향을 미치는데 사용될 수 있다.
RNAi 분자는 별개의 폴리뉴클레오티드 가닥: 센스 가닥 또는 패신저 가닥, 및 안티센스 가닥 또는 가이드 가닥으로부터 만들어질 수 있다. 가이드 및 패신저 가닥은 적어도 부분적으로 상보적이다. 가이드 가닥 및 패신저 가닥은 약 15 내지 약 49 개의 염기쌍을 갖는 듀플렉스 영역을 형성할 수 있다.
일부 구현예에서, siRNA 의 듀플렉스 영역은 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40, 41, 42, 43, 44, 45, 46, 47, 48, 또는 49 개의 염기쌍을 가질 수 있다.
특정 구현예에서, RNAi 분자는 RISC 복합체에서 활성일 수 있으며, RISC 에 관해 활성인 듀플렉스 영역의 길이를 갖는다.
추가 구현예에서, RNAi 분자는 다이서 기질로서 활성이어서, RISC 복합체에서 활성일 수 있는 RNAi 분자로 전환될 수 있다.
일부 양상에서, RNAi 분자는 상보적 가이드 및 패신저 서열 부분을 긴 분자의 대향하는 말단들에 가질 수 있으며, 그에 따라 분자는 상보적 서열 부분들로 듀플렉스 영역을 형성할 수 있고, 가닥들은 듀플렉스 영역의 하나의 말단에 뉴클레오티드 또는 비-뉴클레오티드 링커에 의해 연결된다. 예를 들어, 헤어핀 배열, 또는 스템 및 루프 배열. 가닥들과의 링커 상호작용은 공유 결합 또는 비-공유 상호작용일 수 있다.
본 공개의 RNAi 분자는 핵산의 센스 영역을 핵산의 안티센스 영역에 연결시키는 뉴클레오티드, 비-뉴클레오티드, 또는 혼합된 뉴클레오티드/비-뉴클레오티드 링커를 포함할 수 있다. 뉴클레오티드 링커는 2 개 이상의 뉴클레오티드 길이, 예를 들어 약 3, 4, 5, 6, 7, 8, 9, 또는 10 개 뉴클레오티드 길이의 링커일 수 있다. 뉴클레오티드 링커는 핵산 압타머 (aptamer) 일 수 있다. 본원에서 사용되는 바와 같은 "압타머" 또는 "핵산 압타머" 는 표적 분자에 특이적으로 결합하는 핵산 분자를 지칭하며, 여기서 상기 핵산 분자는 그것의 자연적 환경에서 표적 분자에 의해 인지되는 서열을 포함하는 서열을 갖는다. 대안적으로, 압타머는 표적 분자에 결합하는 핵산 분자일 수 있으며, 여기에서 표적 분자는 핵산에 자연적으로 결합하지 않는다. 예를 들어, 압타머는 단백질의 리간드-결합 도메인에 결합하여, 이로써 천연 발생 리간드와 단백질의 상호작용을 방지하는데 사용될 수 있다. 예를 들어, Gold et al., Annu Rev Biochem, 1995, Vol. 64, pp. 763-797; Brody et al., J. Biotechnol., 2000, Vol. 74, pp. 5-13; Hermann et al., Science, 2000, Vol. 287, pp. 820-825 를 참고한다.
비-뉴클레오티드 링커의 예는 무염기성 뉴클레오티드, 폴리에테르, 폴리아민, 폴리아미드, 펩티드, 탄수화물, 지질, 폴리탄화수소, 또는 다른 폴리머 화합물, 예를 들어 폴리에틸렌 글리콜 예컨대 2 내지 100 개의 에틸렌 글리콜 단위체를 갖는 것들을 포함한다. 일부 예가 Seela et al., Nucleic Acids Research, 1987, Vol. 15, pp. 3113-3129; Cload et al., J. Am. Chem. Soc., 1991, Vol. 113, pp. 6324-6326; Jaeschke et al., Tetrahedron Lett., 1993, Vol. 34, pp. 301; Arnold et al., WO1989/002439; Usman et al., WO1995/006731; Dudycz et al., WO1995/011910, 및 Ferentz et al., J. Am. Chem. Soc., 1991, Vol. 113, pp. 4000-4002 에 기재되어 있다.
RNAi 분자는 듀플렉스 영역으로부터의 오버행을 하나 이상 가질 수 있다. 오버행은 비-염기쌍, 단일 가닥 영역이며, 1 내지 8 개 뉴클레오티드 길이, 또는 그 이상일 수 있다. 오버행은 3'-말단 오버행일 수 있으며, 여기서 가닥의 3'-말단은 1 내지 8 개 뉴클레오티드의 단일 가닥 영역을 갖는다. 오버행은 5'-말단 오버행일 수 있으며, 여기서 가닥의 5'-말단은 1 내지 8 개 뉴클레오티드의 단일 가닥 영역을 갖는다.
RNAi 분자의 오버행은 동일한 길이를 가질 수 있거나, 또는 상이한 길이를 가질 수 있다.
RNAi 분자는 하나 이상의 블런트 엔드를 가질 수 있으며, 여기에서 듀플렉스 영역은 오버행으로 끝나지 않고, 가닥들은 듀플렉스 영역의 말단까지 염기쌍을 이룬다.
본 공개의 RNAi 분자는 하나 이상의 블런트 엔드를 가질 수 있거나, 또는 하나 이상의 오버행을 가질 수 있거나, 또는 블런트 엔드와 오버행 말단의 조합을 가질 수 있다.
RNAi 분자의 가닥의 5'-말단은 블런트 엔드에 있을 수 있거나, 또는 오버행에 있을 수 있다. RNAi 분자의 가닥의 3'-말단은 블런트 엔드에 있을 수 있거나, 또는 오버행에 있을 수 있다.
RNAi 분자의 가닥의 5'-말단은 블런트 엔드에 있을 수 있으며, 한편 3'-말단은 오버행에 있다. RNAi 분자의 가닥의 3'-말단은 블런트 엔드에 있을 수 있으며, 한편 5'-말단은 오버행에 있다.
일부 구현예에서, RNAi 분자의 양쪽 말단은 블런트 엔드이다.
추가 구현예에서, RNAi 분자의 양쪽 말단은 오버행을 갖는다.
5'- 및 3'-말단의 오버행은 상이한 길이를 가질 수 있다.
특정 구현예에서, RNAi 분자는 블런트 엔드를 가질 수 있으며, 여기에서 안티센스 가닥의 5'-말단 및 센스 가닥의 3'-말단은 어떠한 오버행 뉴클레오티드도 갖지 않는다.
추가 구현예에서, RNAi 분자는 블런트 엔드를 가질 수 있으며, 여기에서 안티센스 가닥의 3'-말단 및 센스 가닥의 5'-말단은 어떠한 오버행 뉴클레오티드도 갖지 않는다.
RNAi 분자는 듀플렉스 영역의 염기 쌍형성에서 미스매치를 가질 수 있다.
RNAi 분자의 오버행에서의 임의의 뉴클레오티드는 데옥시리보뉴클레오티드, 또는 리보뉴클레오티드일 수 있다.
하나 이상의 데옥시리보뉴클레오티드는 5'-말단에 있을 수 있으며, 여기에서 RNAi 분자의 다른 가닥의 3'-말단은 오버행을 갖지 않을 수 있거나, 또는 데옥시리보뉴클레오티드 오버행을 갖지 않을 수 있다.
하나 이상의 데옥시리보뉴클레오티드는 3'-말단에 있을 수 있으며, 여기에서 RNAi 분자의 다른 가닥의 5'-말단은 오버행을 갖지 않을 수 있거나, 또는 데옥시리보뉴클레오티드 오버행을 갖지 않을 수 있다.
일부 구현예에서, RNAi 분자의 오버행 뉴클레오티드 중 하나 이상, 또는 전부는 2'-데옥시리보뉴클레오티드일 수 있다.
다이서 기질 RNAi 분자
일부 양상에서, RNAi 분자는 가공되어 RISC 활성 RNAi 분자를 초래할 수 있는, 다이서 기질로서 적합한 길이를 가질 수 있다. 예를 들어, Rossi 등, US2005/0244858 을 참고한다.
다이서 기질인 이중가닥 RNA (dsRNA) 은 다이서에 의해 가공되어 활성 RNAi 분자를 생산하기에 충분한 길이를 가질 수 있고, 추가로 하기 특성 중 하나 이상을 포함할 수 있다: (i) 다이서 기질 dsRNA 는 비대칭일 수 있으며, 예를 들어, 3' 오버행을 안티센스 가닥에 갖고, (ii) 다이서 기질 dsRNA 는 활성 RNAi 분자로의 dsRNA 의 다이서 결합 및 가공의 방향을 지시하는 개질된 3' 말단을 센스 가닥에 가질 수 있다.
특정 구현예에서, 다이서 기질 dsRNA 에서 가장 긴 가닥은 24-30 개 뉴클레오티드 길이일 수 있다.
다이서 기질 dsRNA 는 대칭 또는 비대칭일 수 있다.
일부 구현예에서, 다이서 기질 dsRNA 는 22-28 개 뉴클레오티드의 센스 가닥 및 24-30 개 뉴클레오티드의 안티센스 가닥을 가질 수 있다.
특정 구현예에서, 다이서 기질 dsRNA 는 오버행을 안티센스 가닥의 3' 말단에 가질 수 있다.
추가 구현예에서, 다이서 기질 dsRNA 는 센스 가닥 25 개 뉴클레오티드 길이, 및 안티센스 가닥 27 개 뉴클레오티드 길이와, 2 염기 3'-오버행을 가질 수 있다. 오버행은 1, 2 또는 3 개 뉴클레오티드 길이일 수 있다. 센스 가닥은 또한 5' 인산염을 가질 수 있다.
비대칭 다이서 기질 dsRNA 는 센스 가닥의 3'-말단에 리보뉴클레오티드 중 2 개 대신에 데옥시리보뉴클레오티드 2 개를 가질 수 있다.
다이서 기질 dsRNA 의 센스 가닥은 약 22 내지 약 30, 또는 약 22 내지 약 28; 또는 약 24 내지 약 30; 또는 약 25 내지 약 30; 또는 약 26 내지 약 30; 또는 약 26 내지 29; 또는 약 27 내지 약 28 개 뉴클레오티드 길이일 수 있다.
다이서 기질 dsRNA 의 센스 가닥은 22, 23, 24, 25, 26, 27, 28, 29 또는 30 개 뉴클레오티드 길이일 수 있다.
특정 구현예에서, 다이서 기질 dsRNA 는 적어도 약 25 개 뉴클레오티드 길이, 및 약 30 개 이하의 뉴클레오티드 길이의 센스 및 안티센스 가닥을 가질 수 있다.
특정 구현예에서, 다이서 기질 dsRNA 는 26 내지 29 개 뉴클레오티드 길이의 센스 및 안티센스 가닥을 가질 수 있다.
특정 구현예에서, 다이서 기질 dsRNA 는 27 개 뉴클레오티드 길이의 센스 및 안티센스 가닥을 가질 수 있다.
다이서 기질 dsRNA 의 센스 및 안티센스 가닥은 블런트 엔드인 경우와 같이 동일한 길이일 수 있거나, 또는 오버행을 갖는 경우와 같이 상이한 길이일 수 있거나, 또는 블런트 엔드 및 오버행을 가질 수 있다.
다이서 기질 dsRNA 는 19, 20, 21, 22, 23, 24, 25, 26 또는 27 개 뉴클레오티드 길이의 듀플렉스 영역을 가질 수 있다.
다이서 기질 dsRNA 의 안티센스 가닥은 생물학적 조건 하에, 예컨대 진핵 세포의 세포질 내에서, 센스 가닥의 서열의 적어도 일부분에 어닐링되는 임의의 서열을 가질 수 있다.
센스 및 안티센스 가닥을 갖는 다이서 기질은 제 3 구조, 예컨대 링커 기 또는 링커 올리고뉴클레오티드에 의해 연결될 수 있다. 링커는 dsRNA 의 2 개의 가닥을 연결시켜서, 예를 들어, 어닐링 후에 헤어핀이 형성된다.
다이서 기질의 센스 및 안티센스 가닥은 일반적으로 상보적이지만, 염기 쌍형성에서 미스매치를 가질 수 있다.
일부 구현예에서, 다이서 기질 dsRNA 는 비대칭이며, 센스 가닥은 22-28 개 뉴클레오티드를 갖고 안티센스 가닥은 24-30 개 뉴클레오티드를 가질 수 있다.
다이서 기질 dsRNA 의 가닥 중 하나, 특히 안티센스 가닥의 영역은 적어도 19 개 뉴클레오티드의 서열 길이를 가질 수 있으며, 여기서 이들 뉴클레오티드는 안티센스 가닥의 3' 말단에 인접한 21-뉴클레오티드 영역에 있고 표적 유전자로부터 생산된 RNA 의 뉴클레오티드 서열에 충분히 상보적이다.
다이서 기질 dsRNA 의 안티센스 가닥은 1 내지 9 개 리보뉴클레오티드를 5'-말단에 가져서, 22-28 개 뉴클레오티드의 길이를 초래할 수 있다. 안티센스 가닥이 21 개 뉴클레오티드의 길이를 가질 때, 그 때 1-7 개 리보뉴클레오티드, 또는 2-5 개 리보뉴클레오티드, 또는 4 개 리보뉴클레오티드가 3'-말단에 첨가될 수 있다. 첨가된 리보뉴클레오티드는 임의의 서열을 가질 수 있다.
다이서 기질 dsRNA 의 센스 가닥은 24-30 개 뉴클레오티드를 가질 수 있다. 센스 가닥은 안티센스 가닥과 실질적으로 상보적이어서, 생물학적 조건 하에 안티센스 가닥에 어닐링될 수 있다.
RNAi 분자의 사용 방법
본 발명의 핵산 분자 및 RNAi 분자는 분자의 직접 적용에 의해, 또는 담체 또는 희석제와 조합된 분자로, 세포 또는 조직에 전달될 수 있다.
본 발명의 핵산 분자 및 RNAi 분자는 담체 또는 희석제, 또는 세포 내로의 진입을 보조하고, 촉진하거나 용이하게 하도록 작용하는 임의의 다른 전달 비히클, 예를 들어 바이러스 서열, 바이러스 물질, 또는 지질 또는 리포좀 제형과 분자의 직접 적용에 의해 세포, 조직, 기관 또는 대상체에 전달 또는 투여될 수 있다.
본 발명의 핵산 분자 및 RNAi 분자는 양이온성 지질과 복합화되고, 리포좀 내에 패키징되고, 또는 다르게는 표적 세포 또는 조직에 전달될 수 있다. 핵산 또는 핵산 복합체는 생체외, 또는 생체내로 직접 진피 적용, 경피 적용 또는 주사를 통해 관련 조직에 국소 투여될 수 있다.
전달 시스템은 예를 들어, 수성 및 비수성 겔, 크림, 에멀젼, 마이크로에멀젼, 리포좀, 연고, 수용액 및 비수용액, 로션, 에어로졸, 탄화수소 베이스 및 분말을 포함할 수 있으며, 가용화제 및 투과 증강제와 같은 부형제를 함유할 수 있다.
본 개시물의 조성물 및 방법은, 핵산 분자의 발현을 허용하는 방식으로 본 발명의 하나 이상의 RNAi 분자를 인코딩하는 핵산 서열을 포함하는 발현 벡터를 포함할 수 있다.
본 발명의 핵산 분자 및 RNAi 분자는 DNA 또는 RNA 벡터에 삽입된 전사 단위로부터 발현될 수 있다. 재조합 벡터는 DNA 플라스미드 또는 바이러스 벡터일 수 있다. 핵산 분자의 일시적 발현이 가능하도록 바이러스 벡터가 사용될 수 있다.
예를 들어, 벡터는 듀플렉스의 RNAi 분자의 두 가닥 모두, 또는 자가 상보성이며 따라서 RNAi 분자를 형성하는 단일 핵산 분자를 인코딩하는 서열을 함유할 수 있다. 발현 벡터는 둘 이상의 핵산 분자를 인코딩하는 핵산 서열을 포함할 수 있다.
핵산 분자는 진핵생물 프로모터로부터 세포 내에 발현될 수 있다. 당업자는 임의의 핵산이 적절한 DNA/RNA 벡터로부터 진핵생물 세포에서 발현될 수 있다는 것을 인지하고 있다.
일부 양상에서, 발현 구축물에 의해 인코딩된 dsRNA 구축물의 전사를 위하여, 세포 내로 발현 구축물이 도입되도록 바이러스 구축물을 사용할 수 있다.
지질 제형은 정맥내, 근육내, 또는 복강내 주사, 또는 경구 또는 흡입으로 또는 당업계에 공지되어 있는 다른 방법에 의해 동물에 투여될 수 있다.
올리고뉴클레오티드를 투여하기 위한 약학적으로 허용가능한 제형이 공지되어 있으며 사용될 수 있다.
실시예
실시예 1: siRNA 녹다운 효력을 결정하기 위해 A549 세포주에서 시험관내 트랜스펙션을 수행했다. 표 3 에 제시된 바와 같이, GST-π mRNA 에 관한 투여량 의존적 녹다운을 siRNA 와 함께 관찰했다.
표 3: A549 세포주에서의 GST-π mRNA 에 관한 투여량 의존적 녹다운
실시예 2: 시험관내 녹다운에 관한 프로토콜
트랜스펙션 전 1 일에, 세포를 96-웰 플레이트에 10% FBS 를 함유하는 100 ㎕ 의 DMEM (HyClone Cat. # SH30243.01) 을 함유하는 웰 마다 2 x 103 개의 세포를 플레이팅하고, 공기 중에 5% CO2 의 가습된 분위기를 함유하는 37℃ 인큐베이터에서 배양했다. 트랜스펙션 전에, 배지를 2% FBS 를 함유하는 90 ㎕ 의 Opti-MEM I 감소된 혈청 배지 (Life Technologies Cat. # 31985-070) 로 교체했다. 그 후, 0.2 ㎕ 의 리포펙타민 RNAiMax (Life Technologies Cat. # 13778-100) 를 5 분 동안 실온에서 4.8 ㎕ 의 Opti-MEM I 와 혼합했다. 그 후, 1 ㎕ 의 siRNA 를 4 ㎕ 의 Opti-MEM I 와 혼합하고, LF2000 용액과 조합하고, 볼텍스하지 않으면서 부드럽게 혼합했다. 실온에서 5 분 동안 기다렸다. 혼합물을 추가의 10 분 동안 실온에서 인큐베이션하여 RNA-RNAiMax 복합체가 형성되게 했다. 또한, 10 ㎕ 의 RNA-RNAiMax 복합체를 웰에 첨가하고, 플레이트를 손으로 부드럽게 진탕했다. 세포를 공기 중에 5% CO2 의 가습된 분위기를 함유하는 37℃ 인큐베이터에서 2 시간 동안 인큐베이션했다. 배지를 2% FBS 를 함유하는 신선한 Opti-MEM I 감소된 혈청 배지 (Life Technologies Cat. # 31985-070) 로 교체했다. 트랜스펙션 후 24 시간에, 세포를 빙랭 PBS 로 1 회 세정했다. 세포를 50 ㎕ 의 Cell-to-Ct 세포용해 버퍼 (Life Technologies Cat. # 4391851 C) 로 5-30 분 동안 실온에서 용해했다. 5 ㎕ 의 정지액을 첨가하고, 그것을 2 분 동안 실온에서 인큐베이션했다. mRNA 수준을 RT-qPCR 에 의해 TAQMAN 을 이용하여 즉시 측정했다. 대안적으로는, 샘플을 -80 ℃ 에서 냉동하고 나중에 분석할 수 있었다.
실시예 3: 도 2 는 GST-π siRNA 에 관한 생체 내 녹다운 효력을 보여준다. 도 2 에 제시된 바와 같이, GST-π mRNA 의 투여량 의존적 녹다운을 GST-π 를 표적으로 하는 BU02 siRNA 와 함께 생체 내에서 관찰했다.
실시예 4: 도 3 은 siRNA 를 표적으로 하는 GST-π 에 의한 세포 증식의 억제를 보여준다. 도 3 에 제시된 바와 같이, 증식의 투여량-의존적 억제를 GST-π 를 표적으로 하는 siRNA 와 함께 시험관 내에서 A549 세포주에서 관찰했다.
실시예 5: 도 4 는 GST-π siRNA (BU02) 에 관한 종양 억제 효과를 보여준다. 췌장암 이종이식 모델을 GST-π 를 표적으로 하는 0.75 mg/kg 의 siRNA 에서 비교적 낮은 투여량으로 이용했다. 제 28 일에 GST-π siRNA 는 유의미하고 예상외로 유리한 종양 억제 효능을 입증했다.
본 실험에서, A549 및 PANC-1 세포주를 ATCC 로부터 입수했다. 세포 현탁액을 주사를 위해 얼음 해동된 BD 마트리겔과 1:1 비로 잘 혼합했다. 각각의 마우스 (무흉선 누드 암컷 마우스, 6 내지 8 주, Charles River) 에, 25 G 바늘 및 주사기 (마우스 당 1 접종물) 를 사용하여 2 × 106 (A549) 또는 2.5 × 106 (PANC-1) 세포의 접종물 0.1 ml 으로 우측면에 피하 접종했다. 접종을 위해 마우스를 마취했다. 성립된 종양이 대략 250 - 350 mm3 (A549) 또는 150 - 250 mm3 (PANC-1) 에 도달한 날에, 동물을 꼬리 정맥을 통해 볼루스 주사에 적용했다. 동물을 과다투여된 CO2 에 의해 희생시키고, 종양을 투약 후 상이한 시점에 해부했다. 종양을 먼저 습윤 칭량한 다음, GST-π 녹다운의 측정, siRNA 의 생물분포 (biodistribution), 및 바이오마커 분석을 위해 3 부분으로 분리했다. 샘플을 액체 질소에 스냅 동결하고, 생분석을 위해 처리할 준비가 될 때까지 -80℃ 에서 저장했다.
실시예 6: 동소이식 A549 폐암 마우스 모델. 본 발명의 GST-π siRNA 는 생체내에서 동소이식 (orthotopic) 폐암 종양의 현저한 감소를 나타낼 수 있다. 이 실시예에서, GST-π siRNA 는 생체내에서 리포좀 제형으로 무흉선 누드 마우스의 동소이식 폐암 종양에 투여될 때 유전자 녹다운 효력을 제공했다.
일반적으로, 동소이식 종양 모델은 약물 효능 및 효력에 관한 직접적인 임상 관련성, 뿐만 아니라 개선된 예측의 능력을 나타낼 수 있다. 동소이식 종양 모델에서, 종양 세포는 세포가 유래되는 장기와 동일한 종류의 장기 내로 직접적으로 이식된다.
처리 그룹 및 비히클 컨트롤 그룹에 관해 부검시 측정된 최종 원발성 종양 중량을 비교함으로써 인간 폐암 A549 에 대한 siRNA 제형의 항종양 효능을 평가했다.
동소이식 폐암 종양 억제를 구조 BU2 에 기반하는 GST-π siRNA (SEQ ID NO:1276 및 1341) 에 관해 생체내에서 관찰했다. 동소이식 A549 폐암 마우스 모델을 2 ㎎/㎏ 의 비교적 낮은 용량의 GST-π 를 표적으로 삼는 siRNA 와 함께 이용했다.
이러한 6-주 연구에서 GST-π siRNA 는 유의미하고 예상외로 유리한 폐 종양 억제 효능을 보였다. 43 일 후에, GST-π siRNA 는 현저하게 유리한 종양 억제 효능을 보였으며, 최종 종양 평균 중량은 컨트롤과 비교할 때 2.8-배 만큼 유의미하게 감소했다.
이러한 연구에서, 수컷 NCr nu/nu 마우스, 5-6 주령을 사용했다. 실험 동물을 실험 기간 동안 HEPA 여과되는 환경에서 유지했다. siRNA 제형을 사용 전에 4℃ 에서 보관하고, 마우스에 주사하기 10 분 전에 실온으로 가온했다.
이러한 A549 인간 폐암 동소이식 모델에 관해, 외과적 동소 이식 (SOI) 을 하는 날에, A549 종양 이종이식편을 보유하는 동물의 피하 부위로부터 스톡 종양을 수확하고 RPMI-1640 배지에 놓았다. 괴사 조직을 제거하고, 생존가능한 조직을 1.5-2 ㎣ 조각으로 잘랐다. 동물을 이소플루란 흡입으로 마취하고, 수술 부위를 요오드 및 알코올로 멸균했다. 한 쌍의 외과용 가위를 사용하여 마우스의 왼쪽 가슴 벽에 대략 1.5 ㎝ 길이의 횡행 절개를 수행했다. 제 3 및 제 4 갈비뼈 사이에서 늑골간 절개를 수행했고, 왼쪽 폐를 노출시켰다. 하나의 A549 종양 단편을 8-0 외과용 봉합사 (나일론) 를 사용하여 폐의 표면에 이식했다. 가슴 벽을 6-0 외과용 봉합사 (실크) 로 닫았다. 25 G X 1 ½ 바늘을 갖는 3 cc 주사기를 사용하여 흉내 천자에 의해 폐를 재-팽창시키켜 흉강의 남은 공기를 빼냈다. 가슴 벽을 6-0 외과용 실크 봉합사로 닫았다. 위에 기재된 모든 수술 절차를 HEPA 여과되는 층류 후드 하에서 7 x 배율 현미경을 이용하여 수행했다.
종양 이식 후 3 일에, 모델 종양-보유 마우스를 그룹 당 10 마리 마우스의 그룹으로 무작위로 나누었다. 관심의 그룹에 관해, 10 마리 마우스의 처리를 종양 이식 후 3 일에 개시했다.
관심의 그룹에 관해, 제형은 (이온화가능 지질:콜레스테롤:DOPE:DOPC:DPPE-PEG-2K:DSPE-PEG-2K), 리포좀 조성물이었다. 리포좀은 GST-π siRNA 를 캡슐화했다.
연구 종점을 위해, 처리 개시 후 42 일에 실험 마우스를 희생시켰다. 후속의 분석을 위해 원발성 종양을 잘라내고 전자 밸런스에서 계량했다.
화합물 독성의 추정을 위해, 처리된 및 컨트롤 그룹 내 마우스의 평균 체중을 전체 실험 기간 동안 정상 범위 내에서 유지했다. 마우스에서 독성의 다른 증상이 관찰되지 않았다.
실시예 7: 누드 마우스에서 A549 세포 성장에 대한 GST-π 를 표적하는 작은 간섭 RNA (siRNA) 의 효과 및 장요막 (CAM) 어세이에 대한 혈관신생. GST-π siRNA-플라스미드 및 비-침묵화-플라스미드의 3 개의 쌍을 제작하고, LIPOFECTAMINE 2000 을 통해 각각 A549 세포 내로 트랜스펙션했다. GST-π siRNA-플라스미드의 가장 효과적인 쌍을 ELISA 및 실시간 RT-PCR 에 의해 선별한다. A549 세포를 선별된 GST-π siRNA- 플라스미드로 트랜스펙션시키고, A549 세포를 비-침묵화-플라스미드로 트랜스펙션시키고, 트랜스펙션이 없는 A549 세포를 각각 누드 마우스 내로 접종한다. 병아리 배아를 무작위로 4 그룹으로 나누고, CAM 을 48 시간 동안 하기 상이한 용액으로 처리한다: 음성 컨트롤 그룹으로서 배양 배지 DMEM, 양성 컨트롤 그룹으로서 비-트랜스펙션된 A549 세포 배양 상청액, GST-π siRNA 그룹으로서 GST-π siRNA A549 세포 배양 상청액 및 비-침묵화 siRNA 그룹으로서 비-침묵화 siRNA A549 세포 배양 상청액. 현미경 어세이를 위해, CAM 을 제 12 일에 수확했다.
컨트롤 그룹과 비교하여, GST-π siRNA-플라스미드는 GST-π mRNA 에서 감소를 동반한 A549 세포에 의해 GST-π 분비에서의 감소를 유도한다. 비-침묵화 siRNA 그룹과 비교하여, 쥣과 이종이식의 평균 종양 체적은 GST-π siRNA 그룹에서 감소하고; 50 mm3 까지 성장하는 이종이식에 대한 시간이 지연된다. 이종이식에서의 GST-π 함량은 감소된다. CAM 어세이에서, 음성 그룹에서 GST-π 함량은 0 이고, GST-π siRNA 그룹에서는 비-침묵화 siRNA 그룹 또는 양성 그룹과 비교하여 20-70% 감소한다; GST-π siRNA 그룹 또는 비-침묵화 siRNA 그룹 또는 양성 그룹에서의 CAM 의 혈관 분지점은 음성 그룹과 비교하여 증가된다; GST-π siRNA 그룹에서 CAM 의 총 혈관 길이는 음성 그룹과 비교하여 증가되는 반면, 비-침묵화 siRNA 그룹 또는 양성 그룹에서 이것은 증가된다. 음성 컨트롤 그룹과 비교하여, GST-π 가 있는 세포 배양 상청액을 GST-π siRNA 그룹에 첨가하는 경우 미세혈관의 증식이 증가하고, 비-침묵화 siRNA 그룹 또는 양성 그룹에서 상당히 증식된 혈관이 관찰된다.
실시예 8: 세포 배양. 인간 비-소형 세포 폐 암종 세포주, A549 를 5% CO2 의 가습된 분위기 중의 37 ℃ 에서 10% FBS (FBS, Invitrogen) 가 보충된 F-12K 배지 (ATCC) 에서 배양한다. 컨트롤, 또는 GSTπ siRNA 를 안정하게 발현하는 세포는 제조자의 지침에 따라 (Sigma-Aldrich) A549TR 세포를 각각의 렌티바이러스 형질도입 입자로 형질도입함으로써 발생시킨다. 저항성 클론을 2.5 μg/mL 퓨로마이신 (Invivogen) 에서 12 d 동안 선별하고, 클로닝 원통을 사용하여 단리하고, 이어서 퓨로마이신-함유 배지에서 팽창 및 유지한다.
실시예 9: GST-π 표적화 siRNA 는 생체 내에서 종양 부피의 엄청난 퇴행을 산출한다.
지질 제형은 scid 마우스에서 인간 A549 폐암 세포의 이종이식에 나노입자 중의 siRNA 를 캡슐화 및 전달하는데 사용된다. 정상 세포와 비교하여 KRAS 돌연변이의 존재 또는 이상 발현 수준을 확인하기 위해 이종이식을 시험한다. 종양이 성립되어 질 때 (>100 mm3), 마우스를 2 주 동안 매 2 일 GST-π 표적화 siRNA 또는 컨트롤 (비-특이적) siRNA 로 처리한다. 컨트롤 그룹을 안락사시켜야 할 때 시험을 중단한다.
결과: GST-π 표적화 siRNA 로의 처리는 종양 팽창을 방지하고 현저한 종양 부피 감소를 산출한다.
회수된 종양을 절개하고 TUNEL 염색에 의해 가시화한다. GST-π 표적화 siRNA-처리된 종양은 상당히 더 높은 수준의 세포자멸사를 나타낸다. 종양으로부터 RNA 를 추출하고, GST-π 의 특이적 녹다운을 시험하기 위해 실시간 PCR 을 수행한다.
결과: GST-π 표적화 siRNA 로의 처리는 생체 내 GST-π 의 발현을 현저히 감소시킨다.
실시예 10: 본 발명의 GST-π siRNA 는 증가된 혈청 안정성을 나타냈다.
GST-π siRNA 를 인간 혈청 중 인큐베이션하고 HPLS/LCMS 에 의한 다양한 시점에서의 남은 siRNA 의 검출을 수행했다. GST-π siRNA (SEQ ID No:1276 및 1341) 의 센스 가닥 및 안티센스 가닥 둘 모두에 관한 혈청 중 반감기 (t½) 는 약 100 분이었다.
실시예 11: 본 발명의 GST-π siRNA 는 혈장 중 제형에서 향상된 안정성을 나타냈다.
GST-π siRNA 를 혈장 중 제형에서 인큐베이션하고 다양한 시점에서의 남은 siRNA 의 검출을 수행했다. GST-π siRNA (SEQ ID NO:1276 및 1341) 의 제형의 혈장 중 반감기 (t½) 는 100 시간 보다 유의미하게 더 길었다.
GST-π siRNA 를 조성 (이온화 지질: 콜레스테롤: DOPE: DOPC: DPPE-PEG-2K) (25:30:20:20:5) 을 갖는 리포좀 제형으로 제조했다. 리포좀 나노입자에 관한 z-평균 크기는 40.0 nm 였고, siRNA 는 91% 캡슐화되었다.
제형을 PBS 중 50% 인간 혈청 중 40min, 1.5h, 3h, 24h, 및 96h 동안 인큐베이션했다. GST-π siRNA 의 양을 ELISA-기반 검정에 의해 확인했다.
실시예 12: 본 발명의 GST-π siRNA 는 생체내에서 암 이종이식 종양의 현저한 감소를 나타낼 수 있다. GST-π siRNA 는 생체내에서 리포좀 제형으로 암 이종이식 종양에 투여될 때 유전자 녹다운 효력을 제공할 수 있다.
GST-π siRNA (SEQ ID NO:1276 및 1341) 에 관한 종양 억제 효능이 관찰되었다. GST-π 를 표적으로 삼는 siRNA 로 생체내에서 GST-π mRNA 의 용량 의존적 녹다운이 관찰되었다. 암 이종이식 모델을 GST-π 를 표적으로 삼는 siRNA 와 함께 이용했다.
GST-π siRNA 는 투여 후 수일 내에 유의미하고 예상외로 유리한 종양 억제 효능을 보였다. GST-π siRNA 에 의한 처리는 지질 제형 중 주사 후 4 일에 GST-π mRNA 발현의 유의미한 감소를 초래했다. 4 ㎎/㎏ 의 더 높은 용량에서, 주사 후 24 시간에 약 40% 의 유의미한 감소가 검출되었다.
GST-π siRNA 를 조성 (이온화가능 지질: 콜레스테롤: DOPE: DOPC: DPPE-PEG-2K) (25:30:20:20:5) 을 갖는 리포좀 제형의 10 mL/㎏ 의 단일 주사로 투여했다.
암 이종이식 모델에 관해, A549 세포주를 ATCC 로부터 수득했다. 세포를 10% 우태 혈청 및 100 U/㎖ 페니실린 및 100 ㎍/㎖ 스트렙토마이신으로 보강된 RPMI-1640 에서 유지했다. 세포를 접종 전 48 시간에 분할하여 세포가 수확될 때 로그기 성장에 있게 했다. 세포를 트립신-EDTA 로 약간 트립신화하고, 조직 배양물로부터 수확했다. 생존 세포의 수를 트립판 블루의 존재 하에 혈구계에서 카운트 및 확인했다 (오직 생존 세포를 카운트한다). 세포를 혈청 없는 RPMI 배지에 4 x 107/㎖ 의 농도로 재현탁시켰다. 그 후 세포 현탁액을 주사를 위해 얼음 해동된 BD 마트리겔과 1:1 비로 잘 혼합했다.
마우스는 Charles River Laboratory 무흉선 누드 (nu/nu) 암컷 마우스 (면역-약화된, 6-8 주령, 그룹 당 3 마리의 마우스) 였다.
종양 모델 제조를 위해, 각 마우스에 25 G 바늘 및 주사기를 사용하여 2 x 106 개 A549 세포의 0.1 ㎖ 접종물을, 마우스 당 하나의 접종물을 오른쪽 옆구리에 피하 접종했다. 마우스를 접종을 위해 마취하지 않았다.
종양 부피 측정 및 무작위화를 위해, 종양 크기를 0.1 mm 가까이로 측정했다. 종양 부피를 다음 식을 사용하여 계산했다: 종양 부피 = 길이 x 너비2/2. 종양 부피를 1 주 2 회 모니터링했다. 확립된 종양이 대략 350 - 600 ㎣ 에 도달했을 때, 마우스를 다양한 시점에서 그룹에 배정했다. 동일한 날에, 시험품을 투약 레지멘에 따라 투여했다.
투여량 투여를 위해, 확립된 종양이 대략 350 - 600 ㎣ 에 도달한 날에, 시험품을 4℃ 냉장고에서 꺼냈다. 주사기에 넣기 전에, 제형을 함유하는 병을 손으로 몇 번 뒤집어서 균질한 용액을 만들었다.
체중에 관해, 마우스를 0.1 g 가까이로 계량했다. 체중을 몇 주 동안, 연구 종료일을 포함하여, 나머지 주 동안 2 회 모니터링 및 기록했다.
종양 수집을 위해, 동물을 과다투여된 CO2 에 의해 희생시키고, 종양을 투약 후 0, 24, 48, 72, 96 (선택적), 및 168 시간에 해부했다. 종양을 먼저 습윤 계량하고, 그 후 KD, 분포 및 바이오마커 분석을 위해 3 개의 부분으로 분리했다. 샘플을 액체 질소 중에 급속 냉동시키고, 가공될 준비가 될 때까지 -80 ℃ 에서 보관했다.
본원에서 기재된 구현예는 제한적이 아니고, 당업자는 개선된 RNAi 활성을 갖는 핵산 분자를 식별하기 위해 과도한 실험과정 없이 본원에서 기재된 변형예의 특정 조합이 시험될 수 있다는 것을 쉽게 인지할 수 있다.
본원에서 구체적으로 언급된 모든 공보, 특허 및 문헌은 그 전체가 모든 목적을 위해 참고로 편입된다.
본 발명은 기재된 특정 방법론, 프로토콜, 물질, 및 시약에 제한되지 않으며, 이들은 달라질 수 있다. 또한 본원에서 사용된 용어는 오직 특정한 구현예를 설명하기 위한 것으로 이해될 것이고, 본 발명의 범위를 제한하는 것이 의도되지 않는다. 설명의 범위 및 주제에서 벗어나지 않으면서 본원에서 개시된 설명에 다양한 치환 및 개질이 만들어질 수 있고, 이들 구현예는 이러한 설명 및 첨부된 청구항들의 범위 내에 있다는 것이 당업자에게 쉽게 명백할 것이다.
본 명세서에서 및 첨부된 청구항들에서 사용된 바와 같이, 단수 형태 "하나", "하나의", 및 "그러한" 은 문맥이 명백히 다르게 언급하지 않으면 복수의 언급 대상을 포함한다는 점에 주의해야 한다. 또한, 용어들 "하나" (또는 "하나의"), "하나 이상의" 및 "적어도 하나" 는 본원에서 상호교환적으로 사용될 수 있다. 용어들 "포함한다," "포함하는", "함유하는," "포함되어", 및 "갖는" 은 상호교환적으로 사용될 수 있고, 확장적으로 및 비제한적으로 이해되어야 한다는 점에 또한 주의해야 한다.
본원에서 값의 범위의 언급은, 본원에서 달리 명시되지 않는 한, 단지 범위 내에 있는 각 별개의 값을 개별적으로 언급하는 속기 방법으로서의 역할을 하는 것으로 의도되고, 각 별개의 값은 마치 그것이 본원에서 개별적으로 인용된 것처럼 명세서에 편입된다. 마쿠쉬 그룹에 관해, 당업자는 이러한 설명이 개별적인 구성원, 뿐만 아니라 마쿠쉬 그룹의 구성원의 하위기를 포함한다는 것을 이해할 것이다.
추가의 상세한 설명 없이, 당업자는, 상기 설명에 기반하여, 본 발명을 그것의 최대한의 정도까지 이용할 수 있다고 여겨진다. 하기 특정 구현예는, 따라서, 단지 예시적으로 해석될 것이고, 공개의 나머지를 어떤 식으로든 제한하지 않는다.
본 명세서에 개시된 모든 특징은 임의의 조합으로 조합될 수 있다. 본 명세서에 개시된 각 특색은 동일한, 대등한, 또는 유사한 목적에 기여하는 대안적인 특색으로 대체될 수 있다.
SEQUENCE LISTING
<110> NITTO DENKO CORPORATION
<120> RNA AGENTS FOR GST-PI GENE MODULATION
<130> ND5123202WO
<140>
<141>
<150> 62/184,239
<151> 2015-06-24
<160> 1345
<170> PatentIn version 3.5
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oligonucleotide
<400> 18
ccaugccgcc cuacaccgut t 21
<210> 19
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 19
caugccgccc uacaccgugt t 21
<210> 20
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 20
augccgcccu acaccguggt t 21
<210> 21
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 21
ugccgcccua caccguggut t 21
<210> 22
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 22
gccgcccuac accgugguct t 21
<210> 23
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 23
ccgcccuaca ccguggucut t 21
<210> 24
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 24
cgcccuacac cguggucuat t 21
<210> 25
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 25
gcccuacacc guggucuaut t 21
<210> 26
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 26
cccuacaccg uggucuauut t 21
<210> 27
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 27
ccuacaccgu ggucuauuut t 21
<210> 28
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 28
cuacaccgug gucuauuuct t 21
<210> 29
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 29
uacaccgugg ucuauuucct t 21
<210> 30
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 30
acaccguggu cuauuuccct t 21
<210> 31
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 31
caccgugguc uauuucccat t 21
<210> 32
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 32
accguggucu auuucccagt t 21
<210> 33
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 33
ccguggucua uuucccagut t 21
<210> 34
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 34
cguggucuau uucccaguut t 21
<210> 35
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 35
guggucuauu ucccaguuct t 21
<210> 36
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 36
uggucuauuu cccaguucgt t 21
<210> 37
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 37
ggucuauuuc ccaguucgat t 21
<210> 38
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 38
gucuauuucc caguucgagt t 21
<210> 39
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 39
ucuauuuccc aguucgaggt t 21
<210> 40
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 40
cuauuuccca guucgaggct t 21
<210> 41
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 41
uauuucccag uucgaggcct t 21
<210> 42
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 42
auuucccagu ucgaggccgt t 21
<210> 43
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 43
uuucccaguu cgaggccgct t 21
<210> 44
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 44
uucccaguuc gaggccgcut t 21
<210> 45
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 45
ucccaguucg aggccgcugt t 21
<210> 46
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 46
cccaguucga ggccgcugct t 21
<210> 47
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 47
ccaguucgag gccgcugcgt t 21
<210> 48
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 48
caguucgagg ccgcugcgct t 21
<210> 49
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 49
aguucgaggc cgcugcgcgt t 21
<210> 50
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 50
guucgaggcc gcugcgcggt t 21
<210> 51
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 51
uucgaggccg cugcgcggct t 21
<210> 52
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 52
ucgaggccgc ugcgcggcct t 21
<210> 53
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 53
cgaggccgcu gcgcggccct t 21
<210> 54
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 54
gaggccgcug cgcggcccut t 21
<210> 55
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 55
aggccgcugc gcggcccugt t 21
<210> 56
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 56
ggccgcugcg cggcccugct t 21
<210> 57
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 57
gccgcugcgc ggcccugcgt t 21
<210> 58
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 58
ccgcugcgcg gcccugcgct t 21
<210> 59
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 59
cgcugcgcgg cccugcgcat t 21
<210> 60
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 60
gcugcgcggc ccugcgcaut t 21
<210> 61
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 61
cugcgcggcc cugcgcaugt t 21
<210> 62
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 62
ugcgcggccc ugcgcaugct t 21
<210> 63
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 63
gcgcggcccu gcgcaugcut t 21
<210> 64
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 64
cgcggcccug cgcaugcugt t 21
<210> 65
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 65
gcggcccugc gcaugcugct t 21
<210> 66
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 66
cggcccugcg caugcugcut t 21
<210> 67
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 67
ggcccugcgc augcugcugt t 21
<210> 68
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 68
gcccugcgca ugcugcuggt t 21
<210> 69
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 69
cccugcgcau gcugcuggct t 21
<210> 70
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 70
ccugcgcaug cugcuggcat t 21
<210> 71
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 71
cugcgcaugc ugcuggcagt t 21
<210> 72
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 72
ugcgcaugcu gcuggcagat t 21
<210> 73
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 73
gcgcaugcug cuggcagaut t 21
<210> 74
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 74
cgcaugcugc uggcagauct t 21
<210> 75
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 75
gcaugcugcu ggcagaucat t 21
<210> 76
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 76
caugcugcug gcagaucagt t 21
<210> 77
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 77
augcugcugg cagaucaggt t 21
<210> 78
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 78
ugcugcuggc agaucagggt t 21
<210> 79
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 79
gcugcuggca gaucagggct t 21
<210> 80
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 80
cugcuggcag aucagggcct t 21
<210> 81
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 81
ugcuggcaga ucagggccat t 21
<210> 82
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 82
gcuggcagau cagggccagt t 21
<210> 83
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 83
cuggcagauc agggccagat t 21
<210> 84
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 84
uggcagauca gggccagagt t 21
<210> 85
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 85
ggcagaucag ggccagagct t 21
<210> 86
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 86
gcagaucagg gccagagcut t 21
<210> 87
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 87
cagaucaggg ccagagcugt t 21
<210> 88
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 88
agaucagggc cagagcuggt t 21
<210> 89
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 89
gaucagggcc agagcuggat t 21
<210> 90
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 90
aucagggcca gagcuggaat t 21
<210> 91
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 91
ucagggccag agcuggaagt t 21
<210> 92
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 92
cagggccaga gcuggaaggt t 21
<210> 93
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 93
agggccagag cuggaaggat t 21
<210> 94
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 94
gggccagagc uggaaggagt t 21
<210> 95
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 95
ggccagagcu ggaaggaggt t 21
<210> 96
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 96
gccagagcug gaaggaggat t 21
<210> 97
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 97
ccagagcugg aaggaggagt t 21
<210> 98
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 98
cagagcugga aggaggaggt t 21
<210> 99
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 99
agagcuggaa ggaggaggut t 21
<210> 100
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 100
gagcuggaag gaggaggugt t 21
<210> 101
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 101
gagcuggaag gaggagguat t 21
<210> 102
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 102
agcuggaagg aggagguggt t 21
<210> 103
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 103
gcuggaagga ggagguggut t 21
<210> 104
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 104
cuggaaggag gagguggugt t 21
<210> 105
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 105
uggaaggagg agguggugat t 21
<210> 106
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 106
ggaaggagga gguggugact t 21
<210> 107
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 107
gaaggaggag guggugacct t 21
<210> 108
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 108
aaggaggagg uggugaccgt t 21
<210> 109
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 109
aggaggaggu ggugaccgut t 21
<210> 110
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 110
ggaggaggug gugaccgugt t 21
<210> 111
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 111
gaggaggugg ugaccguggt t 21
<210> 112
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 112
aggagguggu gaccguggat t 21
<210> 113
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 113
ggagguggug accguggagt t 21
<210> 114
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 114
gaggugguga ccguggagat t 21
<210> 115
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 115
agguggugac cguggagact t 21
<210> 116
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 116
gguggugacc guggagacgt t 21
<210> 117
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 117
guggugaccg uggagacgut t 21
<210> 118
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 118
uggugaccgu ggagacgugt t 21
<210> 119
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 119
ggugaccgug gagacguggt t 21
<210> 120
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 120
gugaccgugg agacguggct t 21
<210> 121
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 121
ugaccgugga gacguggcat t 21
<210> 122
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 122
gaccguggag acguggcagt t 21
<210> 123
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 123
accguggaga cguggcaggt t 21
<210> 124
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 124
ccguggagac guggcaggat t 21
<210> 125
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 125
cguggagacg uggcaggagt t 21
<210> 126
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 126
guggagacgu ggcaggaggt t 21
<210> 127
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 127
uggagacgug gcaggagggt t 21
<210> 128
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 128
ggagacgugg caggagggct t 21
<210> 129
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 129
gagacguggc aggagggcut t 21
<210> 130
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 130
agacguggca ggagggcuct t 21
<210> 131
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 131
gacguggcag gagggcucat t 21
<210> 132
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 132
acguggcagg agggcucact t 21
<210> 133
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 133
cguggcagga gggcucacut t 21
<210> 134
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 134
guggcaggag ggcucacuct t 21
<210> 135
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 135
uggcaggagg gcucacucat t 21
<210> 136
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 136
ggcaggaggg cucacucaat t 21
<210> 137
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 137
gcaggagggc ucacucaaat t 21
<210> 138
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 138
caggagggcu cacucaaagt t 21
<210> 139
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 139
aggagggcuc acucaaagct t 21
<210> 140
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 140
ggagggcuca cucaaagcct t 21
<210> 141
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 141
gagggcucac ucaaagccut t 21
<210> 142
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 142
agggcucacu caaagccuct t 21
<210> 143
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 143
gggcucacuc aaagccucct t 21
<210> 144
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 144
ggcucacuca aagccuccut t 21
<210> 145
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 145
gcucacucaa agccuccugt t 21
<210> 146
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 146
cucacucaaa gccuccugct t 21
<210> 147
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 147
ucacucaaag ccuccugcct t 21
<210> 148
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 148
cacucaaagc cuccugccut t 21
<210> 149
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 149
acucaaagcc uccugccuat t 21
<210> 150
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 150
cucaaagccu ccugccuaut t 21
<210> 151
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 151
ucaaagccuc cugccuauat t 21
<210> 152
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 152
caaagccucc ugccuauact t 21
<210> 153
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 153
aaagccuccu gccuauacgt t 21
<210> 154
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 154
aagccuccug ccuauacggt t 21
<210> 155
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 155
agccuccugc cuauacgggt t 21
<210> 156
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 156
gccuccugcc uauacgggct t 21
<210> 157
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 157
ccuccugccu auacgggcat t 21
<210> 158
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 158
cuccugccua uacgggcagt t 21
<210> 159
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 159
uccugccuau acgggcagct t 21
<210> 160
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 160
ccugccuaua cgggcagcut t 21
<210> 161
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 161
cugccuauac gggcagcuct t 21
<210> 162
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 162
ugccuauacg ggcagcucct t 21
<210> 163
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 163
gccuauacgg gcagcuccct t 21
<210> 164
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 164
cccaaguucc aggacggagt t 21
<210> 165
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 165
ccaaguucca ggacggagat t 21
<210> 166
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 166
caaguuccag gacggagact t 21
<210> 167
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 167
aaguuccagg acggagacct t 21
<210> 168
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 168
aguuccagga cggagaccut t 21
<210> 169
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 169
guuccaggac ggagaccuct t 21
<210> 170
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 170
uuccaggacg gagaccucat t 21
<210> 171
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 171
uccaggacgg agaccucact t 21
<210> 172
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 172
ccaggacgga gaccucacct t 21
<210> 173
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 173
caggacggag accucaccct t 21
<210> 174
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 174
aggacggaga ccucacccut t 21
<210> 175
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 175
ggacggagac cucacccugt t 21
<210> 176
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 176
gacggagacc ucacccugut t 21
<210> 177
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 177
acggagaccu cacccuguat t 21
<210> 178
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 178
cggagaccuc acccuguact t 21
<210> 179
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 179
ggagaccuca cccuguacct t 21
<210> 180
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 180
gagaccucac ccuguaccat t 21
<210> 181
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 181
agaccucacc cuguaccagt t 21
<210> 182
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 182
gaccucaccc uguaccagut t 21
<210> 183
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 183
accucacccu guaccaguct t 21
<210> 184
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 184
ccucacccug uaccagucct t 21
<210> 185
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 185
cucacccugu accaguccat t 21
<210> 186
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 186
ucacccugua ccaguccaat t 21
<210> 187
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 187
cacccuguac caguccaaut t 21
<210> 188
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 188
acccuguacc aguccaauat t 21
<210> 189
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 189
cccuguacca guccaauact t 21
<210> 190
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 190
ccuguaccag uccaauacct t 21
<210> 191
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 191
cuguaccagu ccaauaccat t 21
<210> 192
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 192
uguaccaguc caauaccaut t 21
<210> 193
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 193
guaccagucc aauaccauct t 21
<210> 194
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 194
uaccagucca auaccaucct t 21
<210> 195
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 195
accaguccaa uaccauccut t 21
<210> 196
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 196
ccaguccaau accauccugt t 21
<210> 197
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 197
caguccaaua ccauccugct t 21
<210> 198
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 198
aguccaauac cauccugcgt t 21
<210> 199
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 199
guccaauacc auccugcgut t 21
<210> 200
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 200
uccaauacca uccugcguct t 21
<210> 201
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 201
ccaauaccau ccugcgucat t 21
<210> 202
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 202
caauaccauc cugcgucact t 21
<210> 203
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 203
aauaccaucc ugcgucacct t 21
<210> 204
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 204
auaccauccu gcgucaccut t 21
<210> 205
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 205
uaccauccug cgucaccugt t 21
<210> 206
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 206
accauccugc gucaccuggt t 21
<210> 207
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 207
ccauccugcg ucaccugggt t 21
<210> 208
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 208
cauccugcgu caccugggct t 21
<210> 209
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 209
auccugcguc accugggcct t 21
<210> 210
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 210
uccugcguca ccugggccgt t 21
<210> 211
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 211
ccugcgucac cugggccgct t 21
<210> 212
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 212
cugcgucacc ugggccgcat t 21
<210> 213
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 213
ugcgucaccu gggccgcact t 21
<210> 214
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 214
gcgucaccug ggccgcacct t 21
<210> 215
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 215
cgucaccugg gccgcaccct t 21
<210> 216
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 216
gucaccuggg ccgcacccut t 21
<210> 217
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 217
ucaccugggc cgcacccuut t 21
<210> 218
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 218
caccugggcc gcacccuugt t 21
<210> 219
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 219
accugggccg cacccuuggt t 21
<210> 220
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 220
ccugggccgc acccuugggt t 21
<210> 221
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 221
cugggccgca cccuugggct t 21
<210> 222
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 222
ugggccgcac ccuugggcut t 21
<210> 223
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 223
gggccgcacc cuugggcuct t 21
<210> 224
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 224
ggccgcaccc uugggcucut t 21
<210> 225
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 225
gccgcacccu ugggcucuat t 21
<210> 226
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 226
ccgcacccuu gggcucuaut t 21
<210> 227
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 227
cgcacccuug ggcucuaugt t 21
<210> 228
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 228
gcacccuugg gcucuauggt t 21
<210> 229
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 229
cacccuuggg cucuaugggt t 21
<210> 230
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 230
acccuugggc ucuaugggat t 21
<210> 231
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 231
cccuugggcu cuaugggaat t 21
<210> 232
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 232
ccuugggcuc uaugggaagt t 21
<210> 233
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 233
cuugggcucu augggaaggt t 21
<210> 234
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 234
uugggcucua ugggaaggat t 21
<210> 235
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 235
ugggcucuau gggaaggact t 21
<210> 236
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 236
gggcucuaug ggaaggacct t 21
<210> 237
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 237
ggcucuaugg gaaggaccat t 21
<210> 238
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 238
gcucuauggg aaggaccagt t 21
<210> 239
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 239
cucuauggga aggaccagct t 21
<210> 240
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 240
ucuaugggaa ggaccagcat t 21
<210> 241
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 241
cuaugggaag gaccagcagt t 21
<210> 242
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 242
uaugggaagg accagcaggt t 21
<210> 243
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 243
augggaagga ccagcaggat t 21
<210> 244
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 244
ugggaaggac cagcaggagt t 21
<210> 245
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 245
gggaaggacc agcaggaggt t 21
<210> 246
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 246
ggaaggacca gcaggaggct t 21
<210> 247
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 247
gaaggaccag caggaggcat t 21
<210> 248
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 248
aaggaccagc aggaggcagt t 21
<210> 249
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 249
aggaccagca ggaggcagct t 21
<210> 250
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 250
ggaccagcag gaggcagcct t 21
<210> 251
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 251
gaccagcagg aggcagccct t 21
<210> 252
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 252
accagcagga ggcagcccut t 21
<210> 253
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 253
ccagcaggag gcagcccugt t 21
<210> 254
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 254
cagcaggagg cagcccuggt t 21
<210> 255
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 255
agcaggaggc agcccuggut t 21
<210> 256
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 256
gcaggaggca gcccuggugt t 21
<210> 257
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 257
caggaggcag cccugguggt t 21
<210> 258
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 258
aggaggcagc ccugguggat t 21
<210> 259
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 259
ggaggcagcc cugguggact t 21
<210> 260
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 260
gaggcagccc ugguggacat t 21
<210> 261
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 261
aggcagcccu gguggacaut t 21
<210> 262
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 262
ggcagcccug guggacaugt t 21
<210> 263
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 263
gcagcccugg uggacauggt t 21
<210> 264
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 264
cagcccuggu ggacauggut t 21
<210> 265
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 265
agcccuggug gacauggugt t 21
<210> 266
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 266
gcccuggugg acauggugat t 21
<210> 267
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 267
cccuggugga cauggugaat t 21
<210> 268
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 268
ccugguggac auggugaaut t 21
<210> 269
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 269
cugguggaca uggugaaugt t 21
<210> 270
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 270
ugguggacau ggugaaugat t 21
<210> 271
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 271
gguggacaug gugaaugact t 21
<210> 272
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 272
guggacaugg ugaaugacgt t 21
<210> 273
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 273
uggacauggu gaaugacggt t 21
<210> 274
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 274
ggacauggug aaugacggct t 21
<210> 275
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 275
gacaugguga augacggcgt t 21
<210> 276
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 276
acauggugaa ugacggcgut t 21
<210> 277
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 277
cauggugaau gacggcgugt t 21
<210> 278
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 278
auggugaaug acggcguggt t 21
<210> 279
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 279
uggugaauga cggcguggat t 21
<210> 280
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 280
ggugaaugac ggcguggagt t 21
<210> 281
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 281
gugaaugacg gcguggaggt t 21
<210> 282
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 282
ugaaugacgg cguggaggat t 21
<210> 283
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 283
gaaugacggc guggaggact t 21
<210> 284
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 284
aaugacggcg uggaggacct t 21
<210> 285
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 285
augacggcgu ggaggaccut t 21
<210> 286
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 286
ugacggcgug gaggaccuct t 21
<210> 287
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 287
gacggcgugg aggaccucct t 21
<210> 288
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 288
acggcgugga ggaccuccgt t 21
<210> 289
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 289
cggcguggag gaccuccgct t 21
<210> 290
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 290
ggcguggagg accuccgcut t 21
<210> 291
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 291
gcguggagga ccuccgcugt t 21
<210> 292
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 292
cguggaggac cuccgcugct t 21
<210> 293
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 293
guggaggacc uccgcugcat t 21
<210> 294
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 294
uggaggaccu ccgcugcaat t 21
<210> 295
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 295
ggaggaccuc cgcugcaaat t 21
<210> 296
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 296
gaggaccucc gcugcaaaut t 21
<210> 297
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 297
aggaccuccg cugcaaauat t 21
<210> 298
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 298
ggaccuccgc ugcaaauact t 21
<210> 299
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 299
gaccuccgcu gcaaauacat t 21
<210> 300
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 300
accuccgcug caaauacaut t 21
<210> 301
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 301
ccuccgcugc aaauacauct t 21
<210> 302
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 302
cuccgcugca aauacaucut t 21
<210> 303
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 303
uccgcugcaa auacaucuct t 21
<210> 304
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 304
ccgcugcaaa uacaucucct t 21
<210> 305
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 305
cgcugcaaau acaucuccct t 21
<210> 306
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 306
gcugcaaaua caucucccut t 21
<210> 307
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 307
cugcaaauac aucucccuct t 21
<210> 308
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 308
ugcaaauaca ucucccucat t 21
<210> 309
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 309
gcaaauacau cucccucaut t 21
<210> 310
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 310
caaauacauc ucccucauct t 21
<210> 311
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 311
aaauacaucu cccucaucut t 21
<210> 312
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 312
aauacaucuc ccucaucuat t 21
<210> 313
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 313
auacaucucc cucaucuact t 21
<210> 314
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 314
uacaucuccc ucaucuacat t 21
<210> 315
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 315
acaucucccu caucuacact t 21
<210> 316
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 316
caucucccuc aucuacacct t 21
<210> 317
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 317
aucucccuca ucuacaccat t 21
<210> 318
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 318
ucucccucau cuacaccaat t 21
<210> 319
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 319
gcucccucau cuacaccaat t 21
<210> 320
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 320
cucccucauc uacaccaact t 21
<210> 321
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 321
ucccucaucu acaccaacut t 21
<210> 322
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 322
cucccucauc uacaccaaat t 21
<210> 323
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 323
cccucaucua caccaacuat t 21
<210> 324
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 324
ccucaucuac accaacuaut t 21
<210> 325
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 325
ccucaucuac accaacuaat t 21
<210> 326
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 326
cucaucuaca ccaacuaugt t 21
<210> 327
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 327
ucaucuacac caacuaugat t 21
<210> 328
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 328
caucuacacc aacuaugagt t 21
<210> 329
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 329
aucuacacca acuaugaggt t 21
<210> 330
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 330
ucuacaccaa cuaugaggct t 21
<210> 331
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 331
cuacaccaac uaugaggcgt t 21
<210> 332
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 332
uacaccaacu augaggcggt t 21
<210> 333
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 333
acaccaacua ugaggcgggt t 21
<210> 334
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 334
caccaacuau gaggcgggct t 21
<210> 335
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 335
accaacuaug aggcgggcat t 21
<210> 336
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 336
ccaacuauga ggcgggcaat t 21
<210> 337
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 337
caacuaugag gcgggcaagt t 21
<210> 338
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 338
aacuaugagg cgggcaaggt t 21
<210> 339
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 339
acuaugaggc gggcaaggat t 21
<210> 340
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 340
cuaugaggcg ggcaaggaut t 21
<210> 341
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 341
uaugaggcgg gcaaggaugt t 21
<210> 342
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 342
augaggcggg caaggaugat t 21
<210> 343
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 343
ugaggcgggc aaggaugact t 21
<210> 344
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 344
gaggcgggca aggaugacut t 21
<210> 345
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 345
aggcgggcaa ggaugacuat t 21
<210> 346
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 346
ggcgggcaag gaugacuaut t 21
<210> 347
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 347
gcgggcaagg augacuaugt t 21
<210> 348
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 348
cgggcaagga ugacuaugut t 21
<210> 349
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 349
gggcaaggau gacuaugugt t 21
<210> 350
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 350
ggcaaggaug acuaugugat t 21
<210> 351
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 351
gcaaggauga cuaugugaat t 21
<210> 352
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 352
caaggaugac uaugugaagt t 21
<210> 353
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 353
aaggaugacu augugaaggt t 21
<210> 354
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 354
aggaugacua ugugaaggct t 21
<210> 355
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 355
ggaugacuau gugaaggcat t 21
<210> 356
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 356
gaugacuaug ugaaggcact t 21
<210> 357
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 357
augacuaugu gaaggcacut t 21
<210> 358
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 358
ugacuaugug aaggcacugt t 21
<210> 359
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 359
gacuauguga aggcacugct t 21
<210> 360
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 360
acuaugugaa ggcacugcct t 21
<210> 361
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 361
cuaugugaag gcacugccct t 21
<210> 362
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 362
uaugugaagg cacugcccgt t 21
<210> 363
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 363
augugaaggc acugcccggt t 21
<210> 364
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 364
ugugaaggca cugcccgggt t 21
<210> 365
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 365
gugaaggcac ugcccgggct t 21
<210> 366
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 366
ugaaggcacu gcccgggcat t 21
<210> 367
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 367
gaaggcacug cccgggcaat t 21
<210> 368
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 368
aaggcacugc ccgggcaact t 21
<210> 369
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 369
aggcacugcc cgggcaacut t 21
<210> 370
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 370
ggcacugccc gggcaacugt t 21
<210> 371
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 371
gcacugcccg ggcaacugat t 21
<210> 372
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 372
cacugcccgg gcaacugaat t 21
<210> 373
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 373
acugcccggg caacugaagt t 21
<210> 374
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 374
cugcccgggc aacugaagct t 21
<210> 375
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 375
ugcccgggca acugaagcct t 21
<210> 376
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 376
gcccgggcaa cugaagccut t 21
<210> 377
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 377
cccgggcaac ugaagccuut t 21
<210> 378
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 378
ccgggcaacu gaagccuuut t 21
<210> 379
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 379
cgggcaacug aagccuuuut t 21
<210> 380
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 380
gggcaacuga agccuuuugt t 21
<210> 381
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 381
ggcaacugaa gccuuuugat t 21
<210> 382
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 382
gcaacugaag ccuuuugagt t 21
<210> 383
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 383
caacugaagc cuuuugagat t 21
<210> 384
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 384
aacugaagcc uuuugagact t 21
<210> 385
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 385
acugaagccu uuugagacct t 21
<210> 386
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 386
acugaagccu uuugagacat t 21
<210> 387
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 387
cugaagccuu uugagaccct t 21
<210> 388
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 388
ugaagccuuu ugagacccut t 21
<210> 389
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 389
gaagccuuuu gagacccugt t 21
<210> 390
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 390
aagccuuuug agacccugct t 21
<210> 391
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 391
gaagccuuuu gagacccuat t 21
<210> 392
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 392
agccuuuuga gacccugcut t 21
<210> 393
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 393
cgccuuuuga gacccugcat t 21
<210> 394
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 394
agccuuuuga gacccugcat t 21
<210> 395
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 395
gccuuuugag acccugcugt t 21
<210> 396
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 396
ccuuuugaga cccugcugut t 21
<210> 397
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 397
ccuuuugaga cccugcugat t 21
<210> 398
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 398
cuuuugagac ccugcuguct t 21
<210> 399
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 399
cuuuugagac ccugcuguat t 21
<210> 400
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 400
uuuugagacc cugcugucct t 21
<210> 401
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 401
uuugagaccc ugcuguccct t 21
<210> 402
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 402
uugagacccu gcugucccat t 21
<210> 403
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 403
ugagacccug cugucccagt t 21
<210> 404
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 404
gagacccugc ugucccagat t 21
<210> 405
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 405
agacccugcu gucccagaat t 21
<210> 406
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 406
gacccugcug ucccagaact t 21
<210> 407
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 407
acccugcugu cccagaacct t 21
<210> 408
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 408
acccugcugu cccagaacat t 21
<210> 409
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 409
cccugcuguc ccagaaccat t 21
<210> 410
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 410
ccugcugucc cagaaccagt t 21
<210> 411
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 411
cugcuguccc agaaccaggt t 21
<210> 412
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 412
ugcuguccca gaaccagggt t 21
<210> 413
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 413
ugcuguccca gaaccaggat t 21
<210> 414
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 414
gcugucccag aaccagggat t 21
<210> 415
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 415
cugucccaga accagggagt t 21
<210> 416
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 416
ugucccagaa ccagggaggt t 21
<210> 417
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 417
gucccagaac cagggaggct t 21
<210> 418
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 418
ucccagaacc agggaggcat t 21
<210> 419
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 419
cccagaacca gggaggcaat t 21
<210> 420
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 420
ccagaaccag ggaggcaagt t 21
<210> 421
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 421
cagaaccagg gaggcaagat t 21
<210> 422
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 422
agaaccaggg aggcaagact t 21
<210> 423
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 423
gaaccaggga ggcaagacct t 21
<210> 424
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 424
aaccagggag gcaagaccut t 21
<210> 425
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 425
accagggagg caagaccuut t 21
<210> 426
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 426
ccagggaggc aagaccuuct t 21
<210> 427
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 427
cagggaggca agaccuucat t 21
<210> 428
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 428
agggaggcaa gaccuucaut t 21
<210> 429
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 429
gggaggcaag accuucauut t 21
<210> 430
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 430
ggaggcaaga ccuucauugt t 21
<210> 431
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 431
gaggcaagac cuucauugut t 21
<210> 432
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 432
aggcaagacc uucauugugt t 21
<210> 433
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 433
ggcaagaccu ucauuguggt t 21
<210> 434
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 434
gcaagaccuu cauugugggt t 21
<210> 435
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 435
caagaccuuc auugugggat t 21
<210> 436
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 436
aagaccuuca uugugggagt t 21
<210> 437
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 437
agaccuucau ugugggagat t 21
<210> 438
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 438
gaccuucauu gugggagact t 21
<210> 439
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 439
accuucauug ugggagacct t 21
<210> 440
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 440
ccuucauugu gggagaccat t 21
<210> 441
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 441
cuucauugug ggagaccagt t 21
<210> 442
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 442
uucauugugg gagaccagat t 21
<210> 443
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 443
ucauuguggg agaccagaut t 21
<210> 444
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 444
cauuguggga gaccagauct t 21
<210> 445
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 445
auugugggag accagaucut t 21
<210> 446
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 446
uugugggaga ccagaucuct t 21
<210> 447
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 447
ugugggagac cagaucucct t 21
<210> 448
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 448
gugggagacc agaucuccut t 21
<210> 449
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 449
ugggagacca gaucuccuut t 21
<210> 450
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 450
gggagaccag aucuccuuct t 21
<210> 451
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 451
ggagaccaga ucuccuucgt t 21
<210> 452
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 452
gagaccagau cuccuucgct t 21
<210> 453
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 453
agaccagauc uccuucgcut t 21
<210> 454
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 454
gaccagaucu ccuucgcugt t 21
<210> 455
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 455
accagaucuc cuucgcugat t 21
<210> 456
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 456
ccagaucucc uucgcugact t 21
<210> 457
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 457
cagaucuccu ucgcugacut t 21
<210> 458
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 458
agaucuccuu cgcugacuat t 21
<210> 459
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 459
gaucuccuuc gcugacuact t 21
<210> 460
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 460
aucuccuucg cugacuacat t 21
<210> 461
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 461
ucuccuucgc ugacuacaat t 21
<210> 462
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 462
cuccuucgcu gacuacaact t 21
<210> 463
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 463
uccuucgcug acuacaacct t 21
<210> 464
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 464
ccuucgcuga cuacaaccut t 21
<210> 465
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 465
cuucgcugac uacaaccugt t 21
<210> 466
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 466
uucgcugacu acaaccugct t 21
<210> 467
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 467
ucgcugacua caaccugcut t 21
<210> 468
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 468
cgcugacuac aaccugcugt t 21
<210> 469
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 469
gcugacuaca accugcuggt t 21
<210> 470
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 470
cugacuacaa ccugcuggat t 21
<210> 471
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 471
ugacuacaac cugcuggact t 21
<210> 472
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 472
gacuacaacc ugcuggacut t 21
<210> 473
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 473
acuacaaccu gcuggacuut t 21
<210> 474
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 474
cuacaaccug cuggacuugt t 21
<210> 475
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 475
uacaaccugc uggacuugct t 21
<210> 476
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 476
acaaccugcu ggacuugcut t 21
<210> 477
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 477
caaccugcug gacuugcugt t 21
<210> 478
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 478
aaccugcugg acuugcugct t 21
<210> 479
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 479
accugcugga cuugcugcut t 21
<210> 480
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 480
ccugcuggac uugcugcugt t 21
<210> 481
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 481
cugcuggacu ugcugcugat t 21
<210> 482
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 482
ugcuggacuu gcugcugaut t 21
<210> 483
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 483
gcuggacuug cugcugauct t 21
<210> 484
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 484
cuggacuugc ugcugaucct t 21
<210> 485
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 485
uggacuugcu gcugauccat t 21
<210> 486
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 486
ggacuugcug cugauccaut t 21
<210> 487
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 487
gacuugcugc ugauccaugt t 21
<210> 488
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 488
acuugcugcu gauccaugat t 21
<210> 489
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 489
cuugcugcug auccaugagt t 21
<210> 490
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 490
uugcugcuga uccaugaggt t 21
<210> 491
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 491
ugcugcugau ccaugaggut t 21
<210> 492
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 492
gcugcugauc caugagguct t 21
<210> 493
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 493
cugcugaucc augaggucct t 21
<210> 494
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 494
ugcugaucca ugagguccut t 21
<210> 495
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 495
gcugauccau gagguccuat t 21
<210> 496
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 496
cugauccaug agguccuagt t 21
<210> 497
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 497
ugauccauga gguccuagct t 21
<210> 498
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 498
gauccaugag guccuagcct t 21
<210> 499
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 499
auccaugagg uccuagccct t 21
<210> 500
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 500
cccuggcugc cuggaugcgt t 21
<210> 501
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 501
ccuggcugcc uggaugcgut t 21
<210> 502
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 502
cuggcugccu ggaugcguut t 21
<210> 503
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 503
uggcugccug gaugcguuct t 21
<210> 504
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 504
ggcugccugg augcguucct t 21
<210> 505
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 505
gcugccugga ugcguuccct t 21
<210> 506
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 506
cccugcucuc agcauaugut t 21
<210> 507
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 507
ccugcucuca gcauaugugt t 21
<210> 508
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 508
cugcucucag cauauguggt t 21
<210> 509
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 509
ugcucucagc auaugugggt t 21
<210> 510
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 510
gggcgccuca gugcccggct t 21
<210> 511
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 511
ggcgccucag ugcccggcct t 21
<210> 512
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 512
gcgccucagu gcccggccct t 21
<210> 513
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 513
cgccucagug cccggcccat t 21
<210> 514
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 514
gccucagugc ccggcccaat t 21
<210> 515
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 515
ccucagugcc cggcccaagt t 21
<210> 516
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 516
cucagugccc ggcccaagct t 21
<210> 517
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 517
ucagugcccg gcccaagcut t 21
<210> 518
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 518
cagugcccgg cccaagcuct t 21
<210> 519
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 519
agugcccggc ccaagcucat t 21
<210> 520
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 520
gugcccggcc caagcucaat t 21
<210> 521
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 521
ugcccggccc aagcucaagt t 21
<210> 522
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 522
gcccggccca agcucaaggt t 21
<210> 523
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 523
cccggcccaa gcucaaggct t 21
<210> 524
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 524
ccggcccaag cucaaggcct t 21
<210> 525
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 525
cggcccaagc ucaaggccut t 21
<210> 526
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 526
ggcccaagcu caaggccuut t 21
<210> 527
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 527
gcccaagcuc aaggccuuct t 21
<210> 528
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 528
cccaagcuca aggccuucct t 21
<210> 529
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 529
ccaagcucaa ggccuuccut t 21
<210> 530
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 530
caagcucaag gccuuccugt t 21
<210> 531
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 531
aagcucaagg ccuuccuggt t 21
<210> 532
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 532
agcucaaggc cuuccuggct t 21
<210> 533
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 533
gcucaaggcc uuccuggcct t 21
<210> 534
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 534
cucaaggccu uccuggccut t 21
<210> 535
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 535
ucaaggccuu ccuggccuct t 21
<210> 536
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 536
caaggccuuc cuggccucct t 21
<210> 537
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 537
aaggccuucc uggccuccct t 21
<210> 538
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 538
cccugaguac gugaaccuct t 21
<210> 539
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 539
ccugaguacg ugaaccucct t 21
<210> 540
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 540
cugaguacgu gaaccuccct t 21
<210> 541
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 541
cccaucaaug gcaacgggat t 21
<210> 542
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 542
ccaucaaugg caacgggaat t 21
<210> 543
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 543
caucaauggc aacgggaaat t 21
<210> 544
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 544
aucaauggca acgggaaact t 21
<210> 545
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 545
ucaauggcaa cgggaaacat t 21
<210> 546
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 546
caauggcaac gggaaacagt t 21
<210> 547
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 547
aauggcaacg ggaaacagut t 21
<210> 548
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 548
auggcaacgg gaaacagugt t 21
<210> 549
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 549
uggcaacggg aaacagugat t 21
<210> 550
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 550
ggcaacggga aacagugagt t 21
<210> 551
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 551
gcaacgggaa acagugaggt t 21
<210> 552
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 552
caacgggaaa cagugagggt t 21
<210> 553
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 553
aacgggaaac agugagggut t 21
<210> 554
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 554
acgggaaaca gugaggguut t 21
<210> 555
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 555
cgggaaacag ugaggguugt t 21
<210> 556
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 556
gggaaacagu gaggguuggt t 21
<210> 557
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 557
ggaaacagug aggguugggt t 21
<210> 558
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 558
gggacucuga gcgggaggct t 21
<210> 559
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 559
ggacucugag cgggaggcat t 21
<210> 560
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 560
acucugagcg ggaggcagat t 21
<210> 561
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 561
ucugagcggg aggcagagut t 21
<210> 562
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 562
cugagcggga ggcagaguut t 21
<210> 563
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 563
ugagcgggag gcagaguuut t 21
<210> 564
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 564
gagcgggagg cagaguuugt t 21
<210> 565
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 565
agcgggaggc agaguuugct t 21
<210> 566
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 566
gcgggaggca gaguuugcct t 21
<210> 567
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 567
cgggaggcag aguuugccut t 21
<210> 568
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 568
gggaggcaga guuugccuut t 21
<210> 569
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 569
ggaggcagag uuugccuuct t 21
<210> 570
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 570
gaggcagagu uugccuucct t 21
<210> 571
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 571
aggcagaguu ugccuuccut t 21
<210> 572
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 572
ggcagaguuu gccuuccuut t 21
<210> 573
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 573
gcagaguuug ccuuccuuut t 21
<210> 574
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 574
cagaguuugc cuuccuuuct t 21
<210> 575
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 575
agaguuugcc uuccuuucut t 21
<210> 576
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 576
gaguuugccu uccuuucuct t 21
<210> 577
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 577
aguuugccuu ccuuucucct t 21
<210> 578
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 578
guuugccuuc cuuucuccat t 21
<210> 579
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 579
uuugccuucc uuucuccagt t 21
<210> 580
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 580
uugccuuccu uucuccaggt t 21
<210> 581
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 581
ugccuuccuu ucuccaggat t 21
<210> 582
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 582
gccuuccuuu cuccaggact t 21
<210> 583
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 583
ccuuccuuuc uccaggacct t 21
<210> 584
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 584
cuuccuuucu ccaggaccat t 21
<210> 585
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 585
uuccuuucuc caggaccaat t 21
<210> 586
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 586
uccuuucucc aggaccaaut t 21
<210> 587
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 587
ccuuucucca ggaccaauat t 21
<210> 588
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 588
cuuucuccag gaccaauaat t 21
<210> 589
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 589
uuucuccagg accaauaaat t 21
<210> 590
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 590
uucuccagga ccaauaaaat t 21
<210> 591
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 591
ucuccaggac caauaaaaut t 21
<210> 592
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 592
cuccaggacc aauaaaauut t 21
<210> 593
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 593
uccaggacca auaaaauuut t 21
<210> 594
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 594
ccaggaccaa uaaaauuuct t 21
<210> 595
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 595
caggaccaau aaaauuucut t 21
<210> 596
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 596
aggaccaaua aaauuucuat t 21
<210> 597
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 597
ggaccaauaa aauuucuaat t 21
<210> 598
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 598
gaccaauaaa auuucuaagt t 21
<210> 599
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 599
accaauaaaa uuucuaagat t 21
<210> 600
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 600
ccaauaaaau uucuaagagt t 21
<210> 601
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 601
caauaaaauu ucuaagagat t 21
<210> 602
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 602
aauaaaauuu cuaagagagt t 21
<210> 603
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 603
auaaaauuuc uaagagagct t 21
<210> 604
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 604
uaaaauuucu aagagagcut t 21
<210> 605
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 605
aaaauuucua agagagcuat t 21
<210> 606
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 606
aaauuucuaa gagagcuaat t 21
<210> 607
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 607
aauuucuaag agagcuaaat t 21
<210> 608
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 608
auuucuaaga gagcuaaaat t 21
<210> 609
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 609
ugguggcgaa gacugcggcg g 21
<210> 610
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 610
augguggcga agacugcggc g 21
<210> 611
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 611
caugguggcg aagacugcgg c 21
<210> 612
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 612
gcaugguggc gaagacugcg g 21
<210> 613
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 613
ggcauggugg cgaagacugc g 21
<210> 614
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 614
cggcauggug gcgaagacug c 21
<210> 615
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 615
gcggcauggu ggcgaagact g 21
<210> 616
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 616
ggcggcaugg uggcgaagac t 21
<210> 617
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 617
gggcggcaug guggcgaaga c 21
<210> 618
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 618
agggcggcau gguggcgaag a 21
<210> 619
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 619
uagggcggca ugguggcgaa g 21
<210> 620
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 620
guagggcggc augguggcga a 21
<210> 621
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 621
uguagggcgg caugguggcg a 21
<210> 622
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 622
guguagggcg gcaugguggc g 21
<210> 623
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 623
gguguagggc ggcauggugg c 21
<210> 624
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 624
cgguguaggg cggcauggug g 21
<210> 625
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 625
acgguguagg gcggcauggt g 21
<210> 626
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 626
cacgguguag ggcggcaugg t 21
<210> 627
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 627
ccacggugua gggcggcaug g 21
<210> 628
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 628
accacggugu agggcggcat g 21
<210> 629
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 629
gaccacggug uagggcggca t 21
<210> 630
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 630
agaccacggu guagggcggc a 21
<210> 631
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 631
uagaccacgg uguagggcgg c 21
<210> 632
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 632
auagaccacg guguagggcg g 21
<210> 633
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 633
aauagaccac gguguagggc g 21
<210> 634
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 634
aaauagacca cgguguaggg c 21
<210> 635
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 635
gaaauagacc acgguguagg g 21
<210> 636
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 636
ggaaauagac cacgguguag g 21
<210> 637
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 637
gggaaauaga ccacggugua g 21
<210> 638
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 638
ugggaaauag accacggugt a 21
<210> 639
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 639
cugggaaaua gaccacggug t 21
<210> 640
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 640
acugggaaau agaccacggt g 21
<210> 641
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 641
aacugggaaa uagaccacgg t 21
<210> 642
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 642
gaacugggaa auagaccacg g 21
<210> 643
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 643
cgaacuggga aauagaccac g 21
<210> 644
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 644
ucgaacuggg aaauagacca c 21
<210> 645
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 645
cucgaacugg gaaauagacc a 21
<210> 646
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 646
ccucgaacug ggaaauagac c 21
<210> 647
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 647
gccucgaacu gggaaauaga c 21
<210> 648
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 648
ggccucgaac ugggaaauag a 21
<210> 649
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 649
cggccucgaa cugggaaaua g 21
<210> 650
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 650
gcggccucga acugggaaat a 21
<210> 651
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 651
agcggccucg aacugggaaa t 21
<210> 652
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 652
cagcggccuc gaacugggaa a 21
<210> 653
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 653
gcagcggccu cgaacuggga a 21
<210> 654
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 654
cgcagcggcc ucgaacuggg a 21
<210> 655
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 655
gcgcagcggc cucgaacugg g 21
<210> 656
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 656
cgcgcagcgg ccucgaacug g 21
<210> 657
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 657
ccgcgcagcg gccucgaact g 21
<210> 658
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 658
gccgcgcagc ggccucgaac t 21
<210> 659
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 659
ggccgcgcag cggccucgaa c 21
<210> 660
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 660
gggccgcgca gcggccucga a 21
<210> 661
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 661
agggccgcgc agcggccucg a 21
<210> 662
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 662
cagggccgcg cagcggccuc g 21
<210> 663
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 663
gcagggccgc gcagcggcct c 21
<210> 664
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 664
cgcagggccg cgcagcggcc t 21
<210> 665
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 665
gcgcagggcc gcgcagcggc c 21
<210> 666
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 666
ugcgcagggc cgcgcagcgg c 21
<210> 667
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 667
augcgcaggg ccgcgcagcg g 21
<210> 668
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 668
caugcgcagg gccgcgcagc g 21
<210> 669
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 669
gcaugcgcag ggccgcgcag c 21
<210> 670
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 670
agcaugcgca gggccgcgca g 21
<210> 671
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 671
cagcaugcgc agggccgcgc a 21
<210> 672
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 672
gcagcaugcg cagggccgcg c 21
<210> 673
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 673
agcagcaugc gcagggccgc g 21
<210> 674
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 674
cagcagcaug cgcagggccg c 21
<210> 675
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 675
ccagcagcau gcgcagggcc g 21
<210> 676
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 676
gccagcagca ugcgcagggc c 21
<210> 677
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 677
ugccagcagc augcgcaggg c 21
<210> 678
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 678
cugccagcag caugcgcagg g 21
<210> 679
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 679
ucugccagca gcaugcgcag g 21
<210> 680
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 680
aucugccagc agcaugcgca g 21
<210> 681
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 681
gaucugccag cagcaugcgc a 21
<210> 682
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 682
ugaucugcca gcagcaugcg c 21
<210> 683
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 683
cugaucugcc agcagcaugc g 21
<210> 684
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 684
ccugaucugc cagcagcaug c 21
<210> 685
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 685
cccugaucug ccagcagcat g 21
<210> 686
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 686
gcccugaucu gccagcagca t 21
<210> 687
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 687
ggcccugauc ugccagcagc a 21
<210> 688
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 688
uggcccugau cugccagcag c 21
<210> 689
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 689
cuggcccuga ucugccagca g 21
<210> 690
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 690
ucuggcccug aucugccagc a 21
<210> 691
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 691
cucuggcccu gaucugccag c 21
<210> 692
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 692
gcucuggccc ugaucugcca g 21
<210> 693
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 693
agcucuggcc cugaucugcc a 21
<210> 694
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 694
cagcucuggc ccugaucugc c 21
<210> 695
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 695
ccagcucugg cccugaucug c 21
<210> 696
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 696
uccagcucug gcccugauct g 21
<210> 697
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 697
uuccagcucu ggcccugauc t 21
<210> 698
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 698
cuuccagcuc uggcccugat c 21
<210> 699
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 699
ccuuccagcu cuggcccuga t 21
<210> 700
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 700
uccuuccagc ucuggcccug a 21
<210> 701
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 701
cuccuuccag cucuggccct g 21
<210> 702
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 702
ccuccuucca gcucuggccc t 21
<210> 703
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 703
uccuccuucc agcucuggcc c 21
<210> 704
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 704
cuccuccuuc cagcucuggc c 21
<210> 705
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 705
ccuccuccuu ccagcucugg c 21
<210> 706
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 706
accuccuccu uccagcucug g 21
<210> 707
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 707
caccuccucc uuccagcuct g 21
<210> 708
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 708
uaccuccucc uuccagcuct g 21
<210> 709
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 709
ccaccuccuc cuuccagcuc t 21
<210> 710
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 710
accaccuccu ccuuccagct c 21
<210> 711
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 711
caccaccucc uccuuccagc t 21
<210> 712
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 712
ucaccaccuc cuccuuccag c 21
<210> 713
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 713
gucaccaccu ccuccuucca g 21
<210> 714
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 714
ggucaccacc uccuccuucc a 21
<210> 715
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 715
cggucaccac cuccuccuuc c 21
<210> 716
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 716
acggucacca ccuccuccut c 21
<210> 717
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 717
cacggucacc accuccucct t 21
<210> 718
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 718
ccacggucac caccuccucc t 21
<210> 719
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 719
uccacgguca ccaccuccuc c 21
<210> 720
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 720
cuccacgguc accaccucct c 21
<210> 721
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 721
ucuccacggu caccaccucc t 21
<210> 722
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 722
gucuccacgg ucaccaccuc c 21
<210> 723
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 723
cgucuccacg gucaccacct c 21
<210> 724
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 724
acgucuccac ggucaccacc t 21
<210> 725
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 725
cacgucucca cggucaccac c 21
<210> 726
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 726
ccacgucucc acggucacca c 21
<210> 727
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 727
gccacgucuc cacggucacc a 21
<210> 728
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 728
ugccacgucu ccacggucac c 21
<210> 729
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 729
cugccacguc uccacgguca c 21
<210> 730
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 730
ccugccacgu cuccacgguc a 21
<210> 731
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 731
uccugccacg ucuccacggt c 21
<210> 732
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 732
cuccugccac gucuccacgg t 21
<210> 733
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 733
ccuccugcca cgucuccacg g 21
<210> 734
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 734
cccuccugcc acgucuccac g 21
<210> 735
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 735
gcccuccugc cacgucucca c 21
<210> 736
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 736
agcccuccug ccacgucucc a 21
<210> 737
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 737
gagcccuccu gccacgucuc c 21
<210> 738
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 738
ugagcccucc ugccacguct c 21
<210> 739
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 739
gugagcccuc cugccacguc t 21
<210> 740
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 740
agugagcccu ccugccacgt c 21
<210> 741
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 741
gagugagccc uccugccacg t 21
<210> 742
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 742
ugagugagcc cuccugccac g 21
<210> 743
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 743
uugagugagc ccuccugcca c 21
<210> 744
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 744
uuugagugag cccuccugcc a 21
<210> 745
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 745
cuuugaguga gcccuccugc c 21
<210> 746
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 746
gcuuugagug agcccuccug c 21
<210> 747
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 747
ggcuuugagu gagcccucct g 21
<210> 748
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 748
aggcuuugag ugagcccucc t 21
<210> 749
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 749
gaggcuuuga gugagcccuc c 21
<210> 750
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 750
ggaggcuuug agugagccct c 21
<210> 751
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 751
aggaggcuuu gagugagccc t 21
<210> 752
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 752
caggaggcuu ugagugagcc c 21
<210> 753
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 753
gcaggaggcu uugagugagc c 21
<210> 754
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 754
ggcaggaggc uuugagugag c 21
<210> 755
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 755
aggcaggagg cuuugaguga g 21
<210> 756
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 756
uaggcaggag gcuuugagug a 21
<210> 757
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 757
auaggcagga ggcuuugagt g 21
<210> 758
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 758
uauaggcagg aggcuuugag t 21
<210> 759
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 759
guauaggcag gaggcuuuga g 21
<210> 760
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 760
cguauaggca ggaggcuuug a 21
<210> 761
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 761
ccguauaggc aggaggcuut g 21
<210> 762
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 762
cccguauagg caggaggcut t 21
<210> 763
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 763
gcccguauag gcaggaggct t 21
<210> 764
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 764
ugcccguaua ggcaggaggc t 21
<210> 765
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 765
cugcccguau aggcaggagg c 21
<210> 766
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 766
gcugcccgua uaggcaggag g 21
<210> 767
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 767
agcugcccgu auaggcagga g 21
<210> 768
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 768
gagcugcccg uauaggcagg a 21
<210> 769
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 769
ggagcugccc guauaggcag g 21
<210> 770
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 770
gggagcugcc cguauaggca g 21
<210> 771
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 771
cuccguccug gaacuugggg a 21
<210> 772
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 772
ucuccguccu ggaacuuggg g 21
<210> 773
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 773
gucuccgucc uggaacuugg g 21
<210> 774
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 774
ggucuccguc cuggaacuug g 21
<210> 775
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 775
aggucuccgu ccuggaacut g 21
<210> 776
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 776
gaggucuccg uccuggaact t 21
<210> 777
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 777
ugaggucucc guccuggaac t 21
<210> 778
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 778
gugaggucuc cguccuggaa c 21
<210> 779
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 779
ggugaggucu ccguccugga a 21
<210> 780
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 780
gggugagguc uccguccugg a 21
<210> 781
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 781
agggugaggu cuccguccug g 21
<210> 782
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 782
cagggugagg ucuccgucct g 21
<210> 783
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 783
acagggugag gucuccgucc t 21
<210> 784
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 784
uacaggguga ggucuccguc c 21
<210> 785
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 785
guacagggug aggucuccgt c 21
<210> 786
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 786
gguacagggu gaggucuccg t 21
<210> 787
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 787
ugguacaggg ugaggucucc g 21
<210> 788
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 788
cugguacagg gugaggucuc c 21
<210> 789
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 789
acugguacag ggugagguct c 21
<210> 790
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 790
gacugguaca gggugagguc t 21
<210> 791
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 791
ggacugguac agggugaggt c 21
<210> 792
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 792
uggacuggua cagggugagg t 21
<210> 793
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 793
uuggacuggu acagggugag g 21
<210> 794
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 794
auuggacugg uacaggguga g 21
<210> 795
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 795
uauuggacug guacagggug a 21
<210> 796
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 796
guauuggacu gguacagggt g 21
<210> 797
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 797
gguauuggac ugguacaggg t 21
<210> 798
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 798
ugguauugga cugguacagg g 21
<210> 799
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 799
augguauugg acugguacag g 21
<210> 800
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 800
gaugguauug gacugguaca g 21
<210> 801
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 801
ggaugguauu ggacugguac a 21
<210> 802
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 802
aggaugguau uggacuggua c 21
<210> 803
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 803
caggauggua uuggacuggt a 21
<210> 804
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 804
gcaggauggu auuggacugg t 21
<210> 805
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 805
cgcaggaugg uauuggacug g 21
<210> 806
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 806
acgcaggaug guauuggact g 21
<210> 807
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 807
gacgcaggau gguauuggac t 21
<210> 808
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 808
ugacgcagga ugguauugga c 21
<210> 809
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 809
gugacgcagg augguauugg a 21
<210> 810
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 810
ggugacgcag gaugguauug g 21
<210> 811
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 811
aggugacgca ggaugguaut g 21
<210> 812
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 812
caggugacgc aggaugguat t 21
<210> 813
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 813
ccaggugacg caggauggua t 21
<210> 814
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 814
cccaggugac gcaggauggt a 21
<210> 815
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 815
gcccagguga cgcaggaugg t 21
<210> 816
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 816
ggcccaggug acgcaggaug g 21
<210> 817
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 817
cggcccaggu gacgcaggat g 21
<210> 818
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 818
gcggcccagg ugacgcagga t 21
<210> 819
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 819
ugcggcccag gugacgcagg a 21
<210> 820
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 820
gugcggccca ggugacgcag g 21
<210> 821
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 821
ggugcggccc aggugacgca g 21
<210> 822
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 822
gggugcggcc caggugacgc a 21
<210> 823
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 823
agggugcggc ccaggugacg c 21
<210> 824
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 824
aagggugcgg cccaggugac g 21
<210> 825
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 825
caagggugcg gcccagguga c 21
<210> 826
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 826
ccaagggugc ggcccaggug a 21
<210> 827
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 827
cccaagggug cggcccaggt g 21
<210> 828
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 828
gcccaagggu gcggcccagg t 21
<210> 829
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 829
agcccaaggg ugcggcccag g 21
<210> 830
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 830
gagcccaagg gugcggccca g 21
<210> 831
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 831
agagcccaag ggugcggccc a 21
<210> 832
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 832
uagagcccaa gggugcggcc c 21
<210> 833
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 833
auagagccca agggugcggc c 21
<210> 834
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 834
cauagagccc aagggugcgg c 21
<210> 835
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 835
ccauagagcc caagggugcg g 21
<210> 836
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 836
cccauagagc ccaagggugc g 21
<210> 837
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 837
ucccauagag cccaagggug c 21
<210> 838
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 838
uucccauaga gcccaagggt g 21
<210> 839
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 839
cuucccauag agcccaaggg t 21
<210> 840
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 840
ccuucccaua gagcccaagg g 21
<210> 841
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 841
uccuucccau agagcccaag g 21
<210> 842
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 842
guccuuccca uagagcccaa g 21
<210> 843
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 843
gguccuuccc auagagccca a 21
<210> 844
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 844
ugguccuucc cauagagccc a 21
<210> 845
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 845
cugguccuuc ccauagagcc c 21
<210> 846
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 846
gcugguccuu cccauagagc c 21
<210> 847
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 847
ugcugguccu ucccauagag c 21
<210> 848
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 848
cugcuggucc uucccauaga g 21
<210> 849
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 849
ccugcugguc cuucccauag a 21
<210> 850
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 850
uccugcuggu ccuucccaua g 21
<210> 851
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 851
cuccugcugg uccuucccat a 21
<210> 852
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 852
ccuccugcug guccuuccca t 21
<210> 853
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 853
gccuccugcu gguccuuccc a 21
<210> 854
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 854
ugccuccugc ugguccuucc c 21
<210> 855
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 855
cugccuccug cugguccuuc c 21
<210> 856
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 856
gcugccuccu gcugguccut c 21
<210> 857
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 857
ggcugccucc ugcuggucct t 21
<210> 858
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 858
gggcugccuc cugcuggucc t 21
<210> 859
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 859
agggcugccu ccugcugguc c 21
<210> 860
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 860
cagggcugcc uccugcuggt c 21
<210> 861
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 861
ccagggcugc cuccugcugg t 21
<210> 862
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 862
accagggcug ccuccugcug g 21
<210> 863
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 863
caccagggcu gccuccugct g 21
<210> 864
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 864
ccaccagggc ugccuccugc t 21
<210> 865
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 865
uccaccaggg cugccuccug c 21
<210> 866
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 866
guccaccagg gcugccucct g 21
<210> 867
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 867
uguccaccag ggcugccucc t 21
<210> 868
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 868
auguccacca gggcugccuc c 21
<210> 869
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 869
cauguccacc agggcugcct c 21
<210> 870
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 870
ccauguccac cagggcugcc t 21
<210> 871
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 871
accaugucca ccagggcugc c 21
<210> 872
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 872
caccaugucc accagggcug c 21
<210> 873
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 873
ucaccauguc caccagggct g 21
<210> 874
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 874
uucaccaugu ccaccagggc t 21
<210> 875
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 875
auucaccaug uccaccaggg c 21
<210> 876
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 876
cauucaccau guccaccagg g 21
<210> 877
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 877
ucauucacca uguccaccag g 21
<210> 878
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 878
gucauucacc auguccacca g 21
<210> 879
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 879
cgucauucac cauguccacc a 21
<210> 880
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 880
ccgucauuca ccauguccac c 21
<210> 881
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 881
gccgucauuc accaugucca c 21
<210> 882
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 882
cgccgucauu caccaugucc a 21
<210> 883
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 883
acgccgucau ucaccauguc c 21
<210> 884
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 884
cacgccguca uucaccaugt c 21
<210> 885
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 885
ccacgccguc auucaccaug t 21
<210> 886
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 886
uccacgccgu cauucaccat g 21
<210> 887
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 887
cuccacgccg ucauucacca t 21
<210> 888
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 888
ccuccacgcc gucauucacc a 21
<210> 889
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 889
uccuccacgc cgucauucac c 21
<210> 890
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 890
guccuccacg ccgucauuca c 21
<210> 891
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 891
gguccuccac gccgucauuc a 21
<210> 892
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 892
agguccucca cgccgucaut c 21
<210> 893
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 893
gagguccucc acgccgucat t 21
<210> 894
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 894
ggagguccuc cacgccguca t 21
<210> 895
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 895
cggagguccu ccacgccguc a 21
<210> 896
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 896
gcggaggucc uccacgccgt c 21
<210> 897
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 897
agcggagguc cuccacgccg t 21
<210> 898
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 898
cagcggaggu ccuccacgcc g 21
<210> 899
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 899
gcagcggagg uccuccacgc c 21
<210> 900
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 900
ugcagcggag guccuccacg c 21
<210> 901
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 901
uugcagcgga gguccuccac g 21
<210> 902
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 902
uuugcagcgg agguccucca c 21
<210> 903
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 903
auuugcagcg gagguccucc a 21
<210> 904
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 904
uauuugcagc ggagguccuc c 21
<210> 905
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 905
guauuugcag cggaggucct c 21
<210> 906
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 906
uguauuugca gcggaggucc t 21
<210> 907
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 907
auguauuugc agcggagguc c 21
<210> 908
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 908
gauguauuug cagcggaggt c 21
<210> 909
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 909
agauguauuu gcagcggagg t 21
<210> 910
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 910
gagauguauu ugcagcggag g 21
<210> 911
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 911
ggagauguau uugcagcgga g 21
<210> 912
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 912
gggagaugua uuugcagcgg a 21
<210> 913
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 913
agggagaugu auuugcagcg g 21
<210> 914
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 914
gagggagaug uauuugcagc g 21
<210> 915
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 915
ugagggagau guauuugcag c 21
<210> 916
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 916
augagggaga uguauuugca g 21
<210> 917
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 917
gaugagggag auguauuugc a 21
<210> 918
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 918
agaugaggga gauguauuug c 21
<210> 919
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 919
uagaugaggg agauguauut g 21
<210> 920
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 920
guagaugagg gagauguaut t 21
<210> 921
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 921
uguagaugag ggagauguat t 21
<210> 922
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 922
guguagauga gggagaugua t 21
<210> 923
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 923
gguguagaug agggagaugt a 21
<210> 924
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 924
ugguguagau gagggagaug t 21
<210> 925
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 925
uugguguaga ugagggagat g 21
<210> 926
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 926
uugguguaga ugagggagct g 21
<210> 927
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 927
guugguguag augagggaga t 21
<210> 928
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 928
aguuggugua gaugagggag a 21
<210> 929
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 929
uuugguguag augagggaga t 21
<210> 930
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 930
uaguuggugu agaugaggga g 21
<210> 931
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 931
auaguuggug uagaugaggg a 21
<210> 932
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 932
uuaguuggug uagaugaggg a 21
<210> 933
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 933
cauaguuggu guagaugagg g 21
<210> 934
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 934
ucauaguugg uguagaugag g 21
<210> 935
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 935
cucauaguug guguagauga g 21
<210> 936
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 936
ccucauaguu gguguagaug a 21
<210> 937
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 937
gccucauagu ugguguagat g 21
<210> 938
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 938
cgccucauag uugguguaga t 21
<210> 939
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 939
ccgccucaua guugguguag a 21
<210> 940
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 940
cccgccucau aguuggugua g 21
<210> 941
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 941
gcccgccuca uaguuggugt a 21
<210> 942
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 942
ugcccgccuc auaguuggug t 21
<210> 943
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 943
uugcccgccu cauaguuggt g 21
<210> 944
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 944
cuugcccgcc ucauaguugg t 21
<210> 945
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 945
ccuugcccgc cucauaguug g 21
<210> 946
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 946
uccuugcccg ccucauagut g 21
<210> 947
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 947
auccuugccc gccucauagt t 21
<210> 948
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 948
cauccuugcc cgccucauag t 21
<210> 949
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 949
ucauccuugc ccgccucaua g 21
<210> 950
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 950
gucauccuug cccgccucat a 21
<210> 951
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 951
agucauccuu gcccgccuca t 21
<210> 952
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 952
uagucauccu ugcccgccuc a 21
<210> 953
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 953
auagucaucc uugcccgcct c 21
<210> 954
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 954
cauagucauc cuugcccgcc t 21
<210> 955
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 955
acauagucau ccuugcccgc c 21
<210> 956
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 956
cacauaguca uccuugcccg c 21
<210> 957
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 957
ucacauaguc auccuugccc g 21
<210> 958
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 958
uucacauagu cauccuugcc c 21
<210> 959
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 959
cuucacauag ucauccuugc c 21
<210> 960
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 960
ccuucacaua gucauccuug c 21
<210> 961
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 961
gccuucacau agucauccut g 21
<210> 962
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 962
ugccuucaca uagucaucct t 21
<210> 963
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 963
gugccuucac auagucaucc t 21
<210> 964
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 964
agugccuuca cauagucauc c 21
<210> 965
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 965
cagugccuuc acauagucat c 21
<210> 966
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 966
gcagugccuu cacauaguca t 21
<210> 967
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 967
ggcagugccu ucacauaguc a 21
<210> 968
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 968
gggcagugcc uucacauagt c 21
<210> 969
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 969
cgggcagugc cuucacauag t 21
<210> 970
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 970
ccgggcagug ccuucacaua g 21
<210> 971
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 971
cccgggcagu gccuucacat a 21
<210> 972
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 972
gcccgggcag ugccuucaca t 21
<210> 973
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 973
ugcccgggca gugccuucac a 21
<210> 974
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 974
uugcccgggc agugccuuca c 21
<210> 975
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 975
guugcccggg cagugccuuc a 21
<210> 976
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 976
aguugcccgg gcagugccut c 21
<210> 977
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 977
caguugcccg ggcagugcct t 21
<210> 978
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 978
ucaguugccc gggcagugcc t 21
<210> 979
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 979
uucaguugcc cgggcagugc c 21
<210> 980
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 980
cuucaguugc ccgggcagug c 21
<210> 981
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 981
gcuucaguug cccgggcagt g 21
<210> 982
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 982
ggcuucaguu gcccgggcag t 21
<210> 983
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 983
aggcuucagu ugcccgggca g 21
<210> 984
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 984
aaggcuucag uugcccgggc a 21
<210> 985
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 985
aaaggcuuca guugcccggg c 21
<210> 986
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 986
aaaaggcuuc aguugcccgg g 21
<210> 987
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 987
caaaaggcuu caguugcccg g 21
<210> 988
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 988
ucaaaaggcu ucaguugccc g 21
<210> 989
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 989
cucaaaaggc uucaguugcc c 21
<210> 990
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 990
ucucaaaagg cuucaguugc c 21
<210> 991
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 991
gucucaaaag gcuucaguug c 21
<210> 992
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 992
ggucucaaaa ggcuucagut g 21
<210> 993
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 993
ugucucaaaa ggcuucagut g 21
<210> 994
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 994
gggucucaaa aggcuucagt t 21
<210> 995
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 995
agggucucaa aaggcuucag t 21
<210> 996
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 996
cagggucuca aaaggcuuca g 21
<210> 997
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 997
gcagggucuc aaaaggcuuc a 21
<210> 998
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 998
uagggucuca aaaggcuuca g 21
<210> 999
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 999
agcagggucu caaaaggcut c 21
<210> 1000
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 1000
ugcagggucu caaaaggcgt c 21
<210> 1001
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 1001
ugcagggucu caaaaggcut c 21
<210> 1002
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 1002
cagcaggguc ucaaaaggct t 21
<210> 1003
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 1003
acagcagggu cucaaaaggc t 21
<210> 1004
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 1004
ucagcagggu cucaaaaggc t 21
<210> 1005
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 1005
gacagcaggg ucucaaaagg c 21
<210> 1006
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 1006
uacagcaggg ucucaaaagg c 21
<210> 1007
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 1007
ggacagcagg gucucaaaag g 21
<210> 1008
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 1008
gggacagcag ggucucaaaa g 21
<210> 1009
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 1009
ugggacagca gggucucaaa a 21
<210> 1010
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 1010
cugggacagc agggucucaa a 21
<210> 1011
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 1011
ucugggacag cagggucuca a 21
<210> 1012
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 1012
uucugggaca gcagggucuc a 21
<210> 1013
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 1013
guucugggac agcaggguct c 21
<210> 1014
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 1014
gguucuggga cagcaggguc t 21
<210> 1015
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 1015
uguucuggga cagcaggguc t 21
<210> 1016
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 1016
ugguucuggg acagcagggt c 21
<210> 1017
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 1017
cugguucugg gacagcaggg t 21
<210> 1018
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 1018
ccugguucug ggacagcagg g 21
<210> 1019
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 1019
cccugguucu gggacagcag g 21
<210> 1020
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 1020
uccugguucu gggacagcag g 21
<210> 1021
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 1021
ucccugguuc ugggacagca g 21
<210> 1022
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 1022
cucccugguu cugggacagc a 21
<210> 1023
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 1023
ccucccuggu ucugggacag c 21
<210> 1024
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 1024
gccucccugg uucugggaca g 21
<210> 1025
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 1025
ugccucccug guucugggac a 21
<210> 1026
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 1026
uugccucccu gguucuggga c 21
<210> 1027
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 1027
cuugccuccc ugguucuggg a 21
<210> 1028
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 1028
ucuugccucc cugguucugg g 21
<210> 1029
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 1029
gucuugccuc ccugguucug g 21
<210> 1030
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 1030
ggucuugccu cccugguuct g 21
<210> 1031
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 1031
aggucuugcc ucccugguuc t 21
<210> 1032
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 1032
aaggucuugc cucccuggut c 21
<210> 1033
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 1033
gaaggucuug ccucccuggt t 21
<210> 1034
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 1034
ugaaggucuu gccucccugg t 21
<210> 1035
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 1035
augaaggucu ugccucccug g 21
<210> 1036
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 1036
aaugaagguc uugccuccct g 21
<210> 1037
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 1037
caaugaaggu cuugccuccc t 21
<210> 1038
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 1038
acaaugaagg ucuugccucc c 21
<210> 1039
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 1039
cacaaugaag gucuugccuc c 21
<210> 1040
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 1040
ccacaaugaa ggucuugcct c 21
<210> 1041
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 1041
cccacaauga aggucuugcc t 21
<210> 1042
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 1042
ucccacaaug aaggucuugc c 21
<210> 1043
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 1043
cucccacaau gaaggucuug c 21
<210> 1044
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 1044
ucucccacaa ugaaggucut g 21
<210> 1045
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 1045
gucucccaca augaagguct t 21
<210> 1046
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 1046
ggucucccac aaugaagguc t 21
<210> 1047
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 1047
uggucuccca caaugaaggt c 21
<210> 1048
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 1048
cuggucuccc acaaugaagg t 21
<210> 1049
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 1049
ucuggucucc cacaaugaag g 21
<210> 1050
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 1050
aucuggucuc ccacaaugaa g 21
<210> 1051
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 1051
gaucuggucu cccacaauga a 21
<210> 1052
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 1052
agaucugguc ucccacaaug a 21
<210> 1053
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 1053
gagaucuggu cucccacaat g 21
<210> 1054
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 1054
ggagaucugg ucucccacaa t 21
<210> 1055
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 1055
aggagaucug gucucccaca a 21
<210> 1056
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 1056
aaggagaucu ggucucccac a 21
<210> 1057
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 1057
gaaggagauc uggucuccca c 21
<210> 1058
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 1058
cgaaggagau cuggucuccc a 21
<210> 1059
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 1059
gcgaaggaga ucuggucucc c 21
<210> 1060
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 1060
agcgaaggag aucuggucuc c 21
<210> 1061
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 1061
cagcgaagga gaucugguct c 21
<210> 1062
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 1062
ucagcgaagg agaucugguc t 21
<210> 1063
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 1063
gucagcgaag gagaucuggt c 21
<210> 1064
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 1064
agucagcgaa ggagaucugg t 21
<210> 1065
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 1065
uagucagcga aggagaucug g 21
<210> 1066
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 1066
guagucagcg aaggagauct g 21
<210> 1067
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 1067
uguagucagc gaaggagauc t 21
<210> 1068
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 1068
uuguagucag cgaaggagat c 21
<210> 1069
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 1069
guuguaguca gcgaaggaga t 21
<210> 1070
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 1070
gguuguaguc agcgaaggag a 21
<210> 1071
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 1071
agguuguagu cagcgaagga g 21
<210> 1072
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 1072
cagguuguag ucagcgaagg a 21
<210> 1073
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 1073
gcagguugua gucagcgaag g 21
<210> 1074
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 1074
agcagguugu agucagcgaa g 21
<210> 1075
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 1075
cagcagguug uagucagcga a 21
<210> 1076
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 1076
ccagcagguu guagucagcg a 21
<210> 1077
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 1077
uccagcaggu uguagucagc g 21
<210> 1078
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 1078
guccagcagg uuguagucag c 21
<210> 1079
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 1079
aguccagcag guuguaguca g 21
<210> 1080
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 1080
aaguccagca gguuguaguc a 21
<210> 1081
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 1081
caaguccagc agguuguagt c 21
<210> 1082
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 1082
gcaaguccag cagguuguag t 21
<210> 1083
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 1083
agcaagucca gcagguugua g 21
<210> 1084
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 1084
cagcaagucc agcagguugt a 21
<210> 1085
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 1085
gcagcaaguc cagcagguug t 21
<210> 1086
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 1086
agcagcaagu ccagcaggut g 21
<210> 1087
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 1087
cagcagcaag uccagcaggt t 21
<210> 1088
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 1088
ucagcagcaa guccagcagg t 21
<210> 1089
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 1089
aucagcagca aguccagcag g 21
<210> 1090
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 1090
gaucagcagc aaguccagca g 21
<210> 1091
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 1091
ggaucagcag caaguccagc a 21
<210> 1092
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 1092
uggaucagca gcaaguccag c 21
<210> 1093
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 1093
auggaucagc agcaagucca g 21
<210> 1094
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 1094
cauggaucag cagcaagucc a 21
<210> 1095
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 1095
ucauggauca gcagcaaguc c 21
<210> 1096
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 1096
cucauggauc agcagcaagt c 21
<210> 1097
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 1097
ccucauggau cagcagcaag t 21
<210> 1098
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 1098
accucaugga ucagcagcaa g 21
<210> 1099
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 1099
gaccucaugg aucagcagca a 21
<210> 1100
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 1100
ggaccucaug gaucagcagc a 21
<210> 1101
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 1101
aggaccucau ggaucagcag c 21
<210> 1102
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 1102
uaggaccuca uggaucagca g 21
<210> 1103
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 1103
cuaggaccuc auggaucagc a 21
<210> 1104
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 1104
gcuaggaccu cauggaucag c 21
<210> 1105
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 1105
ggcuaggacc ucauggauca g 21
<210> 1106
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 1106
gggcuaggac cucauggauc a 21
<210> 1107
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 1107
cgcauccagg cagccagggg c 21
<210> 1108
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 1108
acgcauccag gcagccaggg g 21
<210> 1109
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 1109
aacgcaucca ggcagccagg g 21
<210> 1110
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 1110
gaacgcaucc aggcagccag g 21
<210> 1111
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 1111
ggaacgcauc caggcagcca g 21
<210> 1112
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 1112
gggaacgcau ccaggcagcc a 21
<210> 1113
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 1113
acauaugcug agagcagggg g 21
<210> 1114
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 1114
cacauaugcu gagagcaggg g 21
<210> 1115
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 1115
ccacauaugc ugagagcagg g 21
<210> 1116
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 1116
cccacauaug cugagagcag g 21
<210> 1117
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 1117
gccgggcacu gaggcgcccc a 21
<210> 1118
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 1118
ggccgggcac ugaggcgccc c 21
<210> 1119
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 1119
gggccgggca cugaggcgcc c 21
<210> 1120
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 1120
ugggccgggc acugaggcgc c 21
<210> 1121
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 1121
uugggccggg cacugaggcg c 21
<210> 1122
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 1122
cuugggccgg gcacugaggc g 21
<210> 1123
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 1123
gcuugggccg ggcacugagg c 21
<210> 1124
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 1124
agcuugggcc gggcacugag g 21
<210> 1125
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 1125
gagcuugggc cgggcacuga g 21
<210> 1126
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 1126
ugagcuuggg ccgggcacug a 21
<210> 1127
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 1127
uugagcuugg gccgggcact g 21
<210> 1128
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 1128
cuugagcuug ggccgggcac t 21
<210> 1129
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 1129
ccuugagcuu gggccgggca c 21
<210> 1130
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 1130
gccuugagcu ugggccgggc a 21
<210> 1131
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 1131
ggccuugagc uugggccggg c 21
<210> 1132
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 1132
aggccuugag cuugggccgg g 21
<210> 1133
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 1133
aaggccuuga gcuugggccg g 21
<210> 1134
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 1134
gaaggccuug agcuugggcc g 21
<210> 1135
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 1135
ggaaggccuu gagcuugggc c 21
<210> 1136
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 1136
aggaaggccu ugagcuuggg c 21
<210> 1137
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 1137
caggaaggcc uugagcuugg g 21
<210> 1138
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 1138
ccaggaaggc cuugagcuug g 21
<210> 1139
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 1139
gccaggaagg ccuugagcut g 21
<210> 1140
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 1140
ggccaggaag gccuugagct t 21
<210> 1141
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 1141
aggccaggaa ggccuugagc t 21
<210> 1142
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 1142
gaggccagga aggccuugag c 21
<210> 1143
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 1143
ggaggccagg aaggccuuga g 21
<210> 1144
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 1144
gggaggccag gaaggccuug a 21
<210> 1145
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 1145
gagguucacg uacucagggg a 21
<210> 1146
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 1146
ggagguucac guacucaggg g 21
<210> 1147
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 1147
gggagguuca cguacucagg g 21
<210> 1148
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 1148
ucccguugcc auugaugggg a 21
<210> 1149
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 1149
uucccguugc cauugauggg g 21
<210> 1150
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 1150
uuucccguug ccauugaugg g 21
<210> 1151
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 1151
guuucccguu gccauugaug g 21
<210> 1152
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 1152
uguuucccgu ugccauugat g 21
<210> 1153
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 1153
cuguuucccg uugccauuga t 21
<210> 1154
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 1154
acuguuuccc guugccauug a 21
<210> 1155
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 1155
cacuguuucc cguugccaut g 21
<210> 1156
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 1156
ucacuguuuc ccguugccat t 21
<210> 1157
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 1157
cucacuguuu cccguugcca t 21
<210> 1158
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 1158
ccucacuguu ucccguugcc a 21
<210> 1159
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 1159
cccucacugu uucccguugc c 21
<210> 1160
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 1160
acccucacug uuucccguug c 21
<210> 1161
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 1161
aacccucacu guuucccgut g 21
<210> 1162
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 1162
caacccucac uguuucccgt t 21
<210> 1163
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 1163
ccaacccuca cuguuucccg t 21
<210> 1164
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 1164
cccaacccuc acuguuuccc g 21
<210> 1165
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 1165
gccucccgcu cagagucccc c 21
<210> 1166
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 1166
ugccucccgc ucagaguccc c 21
<210> 1167
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 1167
ucugccuccc gcucagaguc c 21
<210> 1168
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 1168
acucugccuc ccgcucagag t 21
<210> 1169
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 1169
aacucugccu cccgcucaga g 21
<210> 1170
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 1170
aaacucugcc ucccgcucag a 21
<210> 1171
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 1171
caaacucugc cucccgcuca g 21
<210> 1172
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 1172
gcaaacucug ccucccgcuc a 21
<210> 1173
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 1173
ggcaaacucu gccucccgct c 21
<210> 1174
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 1174
aggcaaacuc ugccucccgc t 21
<210> 1175
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 1175
aaggcaaacu cugccucccg c 21
<210> 1176
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 1176
gaaggcaaac ucugccuccc g 21
<210> 1177
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 1177
ggaaggcaaa cucugccucc c 21
<210> 1178
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 1178
aggaaggcaa acucugccuc c 21
<210> 1179
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 1179
aaggaaggca aacucugcct c 21
<210> 1180
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 1180
aaaggaaggc aaacucugcc t 21
<210> 1181
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 1181
gaaaggaagg caaacucugc c 21
<210> 1182
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 1182
agaaaggaag gcaaacucug c 21
<210> 1183
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 1183
gagaaaggaa ggcaaacuct g 21
<210> 1184
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 1184
ggagaaagga aggcaaacuc t 21
<210> 1185
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 1185
uggagaaagg aaggcaaact c 21
<210> 1186
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 1186
cuggagaaag gaaggcaaac t 21
<210> 1187
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 1187
ccuggagaaa ggaaggcaaa c 21
<210> 1188
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 1188
uccuggagaa aggaaggcaa a 21
<210> 1189
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 1189
guccuggaga aaggaaggca a 21
<210> 1190
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 1190
gguccuggag aaaggaaggc a 21
<210> 1191
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 1191
ugguccugga gaaaggaagg c 21
<210> 1192
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 1192
uugguccugg agaaaggaag g 21
<210> 1193
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 1193
auugguccug gagaaaggaa g 21
<210> 1194
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 1194
uauugguccu ggagaaagga a 21
<210> 1195
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 1195
uuauuggucc uggagaaagg a 21
<210> 1196
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 1196
uuuauugguc cuggagaaag g 21
<210> 1197
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 1197
uuuuauuggu ccuggagaaa g 21
<210> 1198
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 1198
auuuuauugg uccuggagaa a 21
<210> 1199
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 1199
aauuuuauug guccuggaga a 21
<210> 1200
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 1200
aaauuuuauu gguccuggag a 21
<210> 1201
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 1201
gaaauuuuau ugguccugga g 21
<210> 1202
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 1202
agaaauuuua uugguccugg a 21
<210> 1203
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 1203
uagaaauuuu auugguccug g 21
<210> 1204
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 1204
uuagaaauuu uauuggucct g 21
<210> 1205
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 1205
cuuagaaauu uuauuggucc t 21
<210> 1206
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 1206
ucuuagaaau uuuauugguc c 21
<210> 1207
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 1207
cucuuagaaa uuuuauuggt c 21
<210> 1208
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 1208
ucucuuagaa auuuuauugg t 21
<210> 1209
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 1209
cucucuuaga aauuuuauug g 21
<210> 1210
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 1210
gcucucuuag aaauuuuaut g 21
<210> 1211
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 1211
agcucucuua gaaauuuuat t 21
<210> 1212
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 1212
uagcucucuu agaaauuuua t 21
<210> 1213
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 1213
uuagcucucu uagaaauuut a 21
<210> 1214
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 1214
uuuagcucuc uuagaaauut t 21
<210> 1215
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 1215
uuuuagcucu cuuagaaaut t 21
<210> 1216
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 1216
ucccagaacc agggaggcat t 21
<210> 1217
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 1217
cuuuugagac ccugcuguct t 21
<210> 1218
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 1218
cugucccaga accagggagt t 21
<210> 1219
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 1219
ugucccagaa ccagggaggt t 21
<210> 1220
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 1220
aagccuuuug agacccugct t 21
<210> 1221
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 1221
uugagacccu gcugucccat t 21
<210> 1222
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 1222
uuuugagacc cugcugucct t 21
<210> 1223
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 1223
gagacccugc ugucccagat t 21
<210> 1224
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 1224
gcuggaagga ggagguggut t 21
<210> 1225
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 1225
cuggaaggag gagguggugt t 21
<210> 1226
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 1226
ucagggccag agcuggaagt t 21
<210> 1227
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 1227
ugagacccug cugucccagt t 21
<210> 1228
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 1228
agggccagag cuggaaggat t 21
<210> 1229
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 1229
agcuggaagg aggagguggt t 21
<210> 1230
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 1230
agacccugcu gucccagaat t 21
<210> 1231
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 1231
gagcuggaag gaggaggugt t 21
<210> 1232
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 1232
ugcuguccca gaaccagggt t 21
<210> 1233
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 1233
cccagaacca gggaggcaat t 21
<210> 1234
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 1234
ccagaaccag ggaggcaagt t 21
<210> 1235
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 1235
uuugagaccc ugcuguccct t 21
<210> 1236
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 1236
gacccugcug ucccagaact t 21
<210> 1237
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 1237
gaucagggcc agagcuggat t 21
<210> 1238
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 1238
agccuuuuga gacccugcut t 21
<210> 1239
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 1239
gccuuuugag acccugcugt t 21
<210> 1240
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 1240
ccuuuugaga cccugcugut t 21
<210> 1241
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 1241
cgccuuuuga gacccugcat t 21
<210> 1242
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 1242
ccuacaccgu ggucuauuut t 21
<210> 1243
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 1243
ugugggagac cagaucucct t 21
<210> 1244
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 1244
gcgggaggca gaguuugcct t 21
<210> 1245
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 1245
ccuuucucca ggaccaauat t 21
<210> 1246
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 1246
acccugcugu cccagaacct t 21
<210> 1247
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 1247
ggucuauuuc ccaguucgat t 21
<210> 1248
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 1248
cccuggugga cauggugaat t 21
<210> 1249
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 1249
acaucucccu caucuacact t 21
<210> 1250
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 1250
gcaaggauga cuaugugaat t 21
<210> 1251
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 1251
ccuucgcuga cuacaaccut t 21
<210> 1252
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 1252
cuggcagauc agggccagat t 21
<210> 1253
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 1253
gacggagacc ucacccugut t 21
<210> 1254
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 1254
cgggcaagga ugacuaugut t 21
<210> 1255
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 1255
cuuuugagac ccugcuguat t 21
<210> 1256
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 1256
gagcuggaag gaggagguat t 21
<210> 1257
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 1257
acccugcugu cccagaacat t 21
<210> 1258
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 1258
ugcuguccca gaaccaggat t 21
<210> 1259
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 1259
agccuuuuga gacccugcat t 21
<210> 1260
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 1260
ccuuuugaga cccugcugat t 21
<210> 1261
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 1261
ugaagccuuu ugagacccut t 21
<210> 1262
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 1262
acugaagccu uuugagacct t 21
<210> 1263
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 1263
aggaugacua ugugaaggct t 21
<210> 1264
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 1264
ggaugacuau gugaaggcat t 21
<210> 1265
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 1265
gaugacuaug ugaaggcact t 21
<210> 1266
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 1266
cucccucauc uacaccaact t 21
<210> 1267
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 1267
gaagccuuuu gagacccugt t 21
<210> 1268
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 1268
ucucccucau cuacaccaat t 21
<210> 1269
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 1269
ccucaucuac accaacuaut t 21
<210> 1270
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 1270
cccucaucua caccaacuat t 21
<210> 1271
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 1271
caacugaagc cuuuugagat t 21
<210> 1272
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 1272
aacugaagcc uuuugagact t 21
<210> 1273
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 1273
cugaagccuu uugagaccct t 21
<210> 1274
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 1274
ucccucaucu acaccaacut t 21
<210> 1275
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 1275
gcucccucau cuacaccaat t 21
<210> 1276
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 1276
gaagccuuuu gagacccuat t 21
<210> 1277
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 1277
acugaagccu uuugagacat t 21
<210> 1278
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 1278
cucccucauc uacaccaaat t 21
<210> 1279
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 1279
ccucaucuac accaacuaat t 21
<210> 1280
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 1280
accaauaaaa uuucuaagat t 21
<210> 1281
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 1281
ugccucccug guucugggac a 21
<210> 1282
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 1282
gacagcaggg ucucaaaagg c 21
<210> 1283
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 1283
cucccugguu cugggacagc a 21
<210> 1284
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 1284
ccucccuggu ucugggacag c 21
<210> 1285
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 1285
gcagggucuc aaaaggcuuc a 21
<210> 1286
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 1286
ugggacagca gggucucaaa a 21
<210> 1287
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 1287
ggacagcagg gucucaaaag g 21
<210> 1288
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 1288
ucugggacag cagggucuca a 21
<210> 1289
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 1289
accaccuccu ccuuccagct c 21
<210> 1290
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 1290
caccaccucc uccuuccagc t 21
<210> 1291
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 1291
cuuccagcuc uggcccugat c 21
<210> 1292
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 1292
cugggacagc agggucucaa a 21
<210> 1293
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 1293
uccuuccagc ucuggcccug a 21
<210> 1294
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 1294
ccaccuccuc cuuccagcuc t 21
<210> 1295
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 1295
uucugggaca gcagggucuc a 21
<210> 1296
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 1296
caccuccucc uuccagcuct g 21
<210> 1297
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 1297
cccugguucu gggacagcag g 21
<210> 1298
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 1298
uugccucccu gguucuggga c 21
<210> 1299
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 1299
cuugccuccc ugguucuggg a 21
<210> 1300
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 1300
gggacagcag ggucucaaaa g 21
<210> 1301
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 1301
guucugggac agcaggguct c 21
<210> 1302
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 1302
uccagcucug gcccugauct g 21
<210> 1303
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 1303
agcagggucu caaaaggcut c 21
<210> 1304
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 1304
cagcaggguc ucaaaaggct t 21
<210> 1305
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 1305
acagcagggu cucaaaaggc t 21
<210> 1306
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 1306
ugcagggucu caaaaggcgt c 21
<210> 1307
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 1307
aaauagacca cgguguaggg c 21
<210> 1308
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 1308
ggagaucugg ucucccacaa t 21
<210> 1309
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 1309
ggcaaacucu gccucccgct c 21
<210> 1310
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 1310
uauugguccu ggagaaagga a 21
<210> 1311
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 1311
gguucuggga cagcaggguc t 21
<210> 1312
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 1312
ucgaacuggg aaauagacca c 21
<210> 1313
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 1313
uucaccaugu ccaccagggc t 21
<210> 1314
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 1314
guguagauga gggagaugua t 21
<210> 1315
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 1315
uucacauagu cauccuugcc c 21
<210> 1316
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 1316
agguuguagu cagcgaagga g 21
<210> 1317
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 1317
ucuggcccug aucugccagc a 21
<210> 1318
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 1318
acagggugag gucuccgucc t 21
<210> 1319
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 1319
acauagucau ccuugcccgc c 21
<210> 1320
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 1320
uacagcaggg ucucaaaagg c 21
<210> 1321
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 1321
uaccuccucc uuccagcuct g 21
<210> 1322
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 1322
uguucuggga cagcaggguc t 21
<210> 1323
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 1323
uccugguucu gggacagcag g 21
<210> 1324
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 1324
ugcagggucu caaaaggcut c 21
<210> 1325
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 1325
ucagcagggu cucaaaaggc t 21
<210> 1326
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 1326
agggucucaa aaggcuucag t 21
<210> 1327
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 1327
ggucucaaaa ggcuucagut g 21
<210> 1328
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 1328
gccuucacau agucauccut g 21
<210> 1329
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 1329
ugccuucaca uagucaucct t 21
<210> 1330
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 1330
gugccuucac auagucaucc t 21
<210> 1331
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 1331
guugguguag augagggaga t 21
<210> 1332
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 1332
cagggucuca aaaggcuuca g 21
<210> 1333
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 1333
uugguguaga ugagggagat g 21
<210> 1334
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 1334
auaguuggug uagaugaggg a 21
<210> 1335
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 1335
uaguuggugu agaugaggga g 21
<210> 1336
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 1336
ucucaaaagg cuucaguugc c 21
<210> 1337
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 1337
gucucaaaag gcuucaguug c 21
<210> 1338
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 1338
gggucucaaa aggcuucagt t 21
<210> 1339
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 1339
aguuggugua gaugagggag a 21
<210> 1340
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 1340
uugguguaga ugagggagct g 21
<210> 1341
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 1341
uagggucuca aaaggcuuca g 21
<210> 1342
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 1342
ugucucaaaa ggcuucagut g 21
<210> 1343
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 1343
uuugguguag augagggaga t 21
<210> 1344
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 1344
uuaguuggug uagaugaggg a 21
<210> 1345
<211> 21
<212> DNA
<213> Artificial Sequence
<220>
<223> Description of Artificial Sequence: Synthetic
oligonucleotide
<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
oligonucleotide
<400> 1345
ucuuagaaau uuuauugguc c 21
Claims (23)
- 하기와 같은 핵산 분자:
a) 분자는 폴리뉴클레오티드 센스 가닥 및 폴리뉴클레오티드 안티센스 가닥을 가짐;
b) 분자의 각각의 가닥은 15 내지 30 개 뉴클레오티드 길이임;
c) 안티센스 가닥의 15 내지 30 개 뉴클레오티드의 인접 영역은 GST-π 를 인코딩하는 mRNA 의 서열과 상보적임;
d) 센스 가닥의 적어도 일부는 안티센스 가닥의 적어도 일부에 상보적이고, 분자는 15 내지 30 개 뉴클레오티드 길이의 듀플렉스 영역을 가짐. - 제 1 항에 있어서, 안티센스 가닥이 SEQ ID NO:1341 이고, 센스 가닥이 SEQ ID NO:1276 이거나, 또는 이의 화학적으로 개질된 가닥인 핵산 분자.
- 제 1 항에 있어서, 안티센스 가닥이 SEQ ID NO:1305 이고, 센스 가닥이 SEQ ID NO:1240 이거나, 또는 이의 화학적으로 개질된 가닥인 핵산 분자.
- 제 1 항에 있어서, GST-π 를 인코딩하는 mRNA 의 서열에 상보적인 안티센스 가닥의 15 내지 30 개 뉴클레오티드의 인접 영역이 분자의 듀플렉스 영역에 위치하는 핵산 분자.
- 제 1 항에 있어서, GST-π 를 인코딩하는 mRNA 의 서열에 상보적인 안티센스 가닥의 15 내지 30 개 뉴클레오티드의 인접 영역이 인간 GSTP1 의 서열로부터 선택되고, 인간 GSTP1 mRNA 가 SEQ ID NO:1 인 핵산 분자.
- 제 1 항에 있어서, GST-π 를 인코딩하는 mRNA 의 서열이 SEQ ID NO:1 의 5'UTR 위치 1 내지 249, SEQ ID NO:1 의 CDS 위치 250 내지 882, 및 SEQ ID NO:1 의 3'UTR 위치 883 내지 986 으로 이루어지는 군으로부터 선택되는 핵산 분자.
- 제 1 항에 있어서, 안티센스 가닥이 SEQ ID NO:609-1215 중 어느 하나로부터 선택되는 서열을 함유하는 핵산 분자.
- 제 1 항에 있어서, 안티센스 가닥이 SEQ ID NO:1281-1345 중 어느 하나로부터 선택되는 서열을 함유하는 핵산 분자.
- 제 1 항에 있어서, 분자가 SEQ ID NO:1240 및 1305, SEQ ID NO:1265 및 1330, SEQ ID NO:1267 및 1332, SEQ ID NO:1269 및 1334, 및 SEQ ID NO:1276 및 1341 로 이루어지는 군으로부터 선택되는 안티센스 및 센스 가닥 쌍으로 구성되는 핵산 분자.
- 제 1 항에 있어서, 분자의 각각의 가닥이 18 내지 22 개 뉴클레오티드 길이인 핵산 분자.
- 제 1 항에 있어서, 듀플렉스 영역이 19 개 뉴클레오티드 길이인 핵산 분자.
- 제 1 항에 있어서, 폴리뉴클레오티드 센스 가닥 및 폴리뉴클레오티드 안티센스 가닥이 단일 가닥으로서 연결되고, 루프에 의해 하나의 말단에서 연결된 듀플렉스 영역을 형성하는 핵산 분자.
- 제 1 항에 있어서, 분자가 블런트 말단을 갖는 핵산 분자.
- 제 1 항에 있어서, 분자가 하나 이상의 3' 오버행을 갖는 핵산 분자.
- 제 1 항에 있어서, 분자가 유전자 침묵화에 활성인 RNAi 분자인 핵산 분자.
- 제 1 항에 있어서, 분자가 유전자 침묵화에 활성인 dsRNA, siRNA, 마이크로-RNA, 또는 shRNA 인 핵산 분자.
- 제 1 항에 있어서, 분자가 GST-π 의 발현 억제에 활성인 핵산 분자.
- 제 1 항에 있어서, 분자가 100 pM 미만의 GST-π 의 녹다운에 대한 IC50 을 갖는 핵산 분자.
- 제 1 항 내지 제 18 항 중 어느 한 항의 핵산 분자 하나 이상 및 약학적으로 허용가능한 담체를 포함하는 조성물.
- 제 19 항에 있어서, 담체가 지질 분자 또는 리포좀인 조성물.
- GST-π 발현과 연관된 질환의 치료 방법으로서, 제 19 항의 조성물을 이를 필요로 하는 대상체에게 투여하는 것을 포함하는 방법.
- 제 21 항에 있어서, 질환이 악성 종양인 방법.
- 제 22 항에 있어서, 악성 종양이 GST-π 발현과 연관된 암, 돌연변이된 KRAS 를 발현하는 세포에 의해 야기되는 암, 육종, 섬유육종, 악성 섬유 조직구종, 지방육종, 횡문근육종, 평활근육종, 혈관육종, 카포시 육종, 림프관 육종, 활액막 육종, 연골육종, 골육종, 암종, 뇌종양, 두경부암, 유방암, 폐암, 식도암, 위암, 십이지장암, 결장직장암, 결장암, 간암, 췌장암, 담낭암, 담관암, 신장암, 요도암, 방광암, 전립선암, 고환암, 음경암, 자궁암, 난소암, 피부암, 뼈암, 백혈병, 악성 림프종, 상피성 악성 종양, 및 비-상피성 악성 종양으로 이루어지는 군으로부터 선택되는 질환에 존재하는 방법.
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