US6399754B1
(en)
*
|
1991-12-24 |
2002-06-04 |
Isis Pharmaceuticals, Inc. |
Sugar modified oligonucleotides
|
EP1253199A1
(en)
*
|
1993-09-02 |
2002-10-30 |
Ribozyme Pharmaceuticals, Inc. |
Abasic moieties containing enzymatic nucleic acids
|
CA2176035A1
(en)
|
1993-11-08 |
1995-05-18 |
Nassim Usman |
Base-modified enzymatic nucleic acid
|
US5672501A
(en)
*
|
1994-12-23 |
1997-09-30 |
Ribozyme Pharmaceuticals, Inc. |
Base-modified enzymatic nucleic acid
|
US7034009B2
(en)
|
1995-10-26 |
2006-04-25 |
Sirna Therapeutics, Inc. |
Enzymatic nucleic acid-mediated treatment of ocular diseases or conditions related to levels of vascular endothelial growth factor receptor (VEGF-R)
|
US5998203A
(en)
*
|
1996-04-16 |
1999-12-07 |
Ribozyme Pharmaceuticals, Inc. |
Enzymatic nucleic acids containing 5'-and/or 3'-cap structures
|
US5728818A
(en)
*
|
1996-01-16 |
1998-03-17 |
Ribozyme Pharmaceuticals, Inc. |
Chemical linkage of ribozyme protions
|
US20040161777A1
(en)
*
|
1996-06-06 |
2004-08-19 |
Baker Brenda F. |
Modified oligonucleotides for use in RNA interference
|
US9096636B2
(en)
*
|
1996-06-06 |
2015-08-04 |
Isis Pharmaceuticals, Inc. |
Chimeric oligomeric compounds and their use in gene modulation
|
US20040147022A1
(en)
*
|
1996-06-06 |
2004-07-29 |
Baker Brenda F. |
2'-methoxy substituted oligomeric compounds and compositions for use in gene modulations
|
US20040266706A1
(en)
*
|
2002-11-05 |
2004-12-30 |
Muthiah Manoharan |
Cross-linked oligomeric compounds and their use in gene modulation
|
US20030044941A1
(en)
*
|
1996-06-06 |
2003-03-06 |
Crooke Stanley T. |
Human RNase III and compositions and uses thereof
|
US20040203024A1
(en)
*
|
1996-06-06 |
2004-10-14 |
Baker Brenda F. |
Modified oligonucleotides for use in RNA interference
|
US20040171030A1
(en)
*
|
1996-06-06 |
2004-09-02 |
Baker Brenda F. |
Oligomeric compounds having modified bases for binding to cytosine and uracil or thymine and their use in gene modulation
|
US20040171028A1
(en)
*
|
1996-06-06 |
2004-09-02 |
Baker Brenda F. |
Phosphorous-linked oligomeric compounds and their use in gene modulation
|
US20040171031A1
(en)
*
|
1996-06-06 |
2004-09-02 |
Baker Brenda F. |
Sugar surrogate-containing oligomeric compounds and compositions for use in gene modulation
|
US20050119470A1
(en)
*
|
1996-06-06 |
2005-06-02 |
Muthiah Manoharan |
Conjugated oligomeric compounds and their use in gene modulation
|
US5898031A
(en)
|
1996-06-06 |
1999-04-27 |
Isis Pharmaceuticals, Inc. |
Oligoribonucleotides for cleaving RNA
|
US7812149B2
(en)
|
1996-06-06 |
2010-10-12 |
Isis Pharmaceuticals, Inc. |
2′-Fluoro substituted oligomeric compounds and compositions for use in gene modulations
|
US20050053976A1
(en)
*
|
1996-06-06 |
2005-03-10 |
Baker Brenda F. |
Chimeric oligomeric compounds and their use in gene modulation
|
US5807743A
(en)
*
|
1996-12-03 |
1998-09-15 |
Ribozyme Pharmaceuticals, Inc. |
Interleukin-2 receptor gamma-chain ribozymes
|
US6251666B1
(en)
|
1997-03-31 |
2001-06-26 |
Ribozyme Pharmaceuticals, Inc. |
Nucleic acid catalysts comprising L-nucleotide analogs
|
US6280936B1
(en)
|
1997-06-09 |
2001-08-28 |
Ribozyme Pharmaceuticals, Inc. |
Method for screening nucleic acid catalysts
|
US6548657B1
(en)
|
1997-06-09 |
2003-04-15 |
Ribozyme Pharmaceuticals, Inc. |
Method for screening nucleic acid catalysts
|
EP1030913A2
(en)
*
|
1997-09-22 |
2000-08-30 |
Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. |
Nucleic acid catalysts with endonuclease activity
|
US6656731B1
(en)
|
1997-09-22 |
2003-12-02 |
Max Planck Gesellschaft Zur Forderung Der Wissenschaften E.V. |
Nucleic acid catalysts with endonuclease activity
|
US6420115B1
(en)
|
1999-12-21 |
2002-07-16 |
Ingeneus Corporation |
Cation mediated triplex hybridization assay
|
US6403313B1
(en)
|
1999-12-21 |
2002-06-11 |
Ingeneus Corporation |
Fluorescent intensity assay for duplex and triplex nucleic acid hybridization solution utilizing fluorescent intercalators
|
US6858390B2
(en)
|
1998-12-31 |
2005-02-22 |
Ingeneus Corporation |
Aptamers containing sequences of nucleic acid or nucleic acid analogues bound homologously, or in novel complexes
|
US6656692B2
(en)
|
1999-12-21 |
2003-12-02 |
Ingeneus Corporation |
Parallel or antiparallel, homologous or complementary binding of nucleic acids or analogues thereof to form duplex, triplex or quadruplex complexes
|
US6911536B1
(en)
|
1999-12-21 |
2005-06-28 |
Ingeneus Corporation |
Triplex and quadruplex catalytic hybridization
|
US7309569B2
(en)
|
1999-12-21 |
2007-12-18 |
Ingeneus, Inc. |
Parallel or antiparallel, homologous or complementary binding of nucleic acids or analogues thereof to form duplex, triplex or quadruplex complexes
|
US7052844B2
(en)
*
|
1999-12-21 |
2006-05-30 |
Ingeneus, Inc. |
Purification of DS-DNA using heteropolymeric capture probes and a triplex, quadruplex or homologous duplex binding mechanism
|
US6927027B2
(en)
|
1999-12-21 |
2005-08-09 |
Ingeneus Corporation |
Nucleic acid multiplex formation
|
US6924108B2
(en)
|
1999-12-21 |
2005-08-02 |
Ingeneus Corporation |
Nucleic acid binding enhancement by conjugation with nucleotides, nucleosides, bases and/or their analogues
|
US20030181412A1
(en)
*
|
1999-12-21 |
2003-09-25 |
Ingeneus Corporation |
Method for modifying transcription and/or translation in an organism for therapeutic, prophylactic and/or analytic uses
|
US6613524B1
(en)
|
2000-01-24 |
2003-09-02 |
Ingeneus Corporation |
Amperometric affinity assay and electrically stimulated complexes of nucleic acids
|
US7220541B2
(en)
|
2000-01-24 |
2007-05-22 |
Ingeneus, Inc. |
Homogeneous assay of biopolymer binding by means of multiple measurements under varied conditions
|
US6982147B2
(en)
*
|
2000-01-24 |
2006-01-03 |
Ingeneus Corporation |
Apparatus for assaying biopolymer binding by means of multiple measurements under varied conditions
|
US20030170659A1
(en)
*
|
2000-01-24 |
2003-09-11 |
Ingeneus Corporation |
Electrical treatment of binding media to encourage, discourage and/or study biopolymer binding
|
US6831171B2
(en)
|
2000-02-08 |
2004-12-14 |
Yale University |
Nucleic acid catalysts with endonuclease activity
|
US20080039414A1
(en)
*
|
2002-02-20 |
2008-02-14 |
Sima Therapeutics, Inc. |
RNA interference mediated inhibition of gene expression using chemically modified short interfering nucleic acid (siNA)
|
US7491805B2
(en)
|
2001-05-18 |
2009-02-17 |
Sirna Therapeutics, Inc. |
Conjugates and compositions for cellular delivery
|
US20050233329A1
(en)
*
|
2002-02-20 |
2005-10-20 |
Sirna Therapeutics, Inc. |
Inhibition of gene expression using duplex forming oligonucleotides
|
US8202979B2
(en)
*
|
2002-02-20 |
2012-06-19 |
Sirna Therapeutics, Inc. |
RNA interference mediated inhibition of gene expression using chemically modified short interfering nucleic acid
|
US8273866B2
(en)
|
2002-02-20 |
2012-09-25 |
Merck Sharp & Dohme Corp. |
RNA interference mediated inhibition of gene expression using chemically modified short interfering nucleic acid (SINA)
|
US20050032733A1
(en)
*
|
2001-05-18 |
2005-02-10 |
Sirna Therapeutics, Inc. |
RNA interference mediated inhibition of gene expression using chemically modified short interfering nucleic acid (SiNA)
|
US7833992B2
(en)
|
2001-05-18 |
2010-11-16 |
Merck Sharpe & Dohme |
Conjugates and compositions for cellular delivery
|
JP2003525037A
(ja)
*
|
2000-02-11 |
2003-08-26 |
リボザイム・ファーマシューティカルズ・インコーポレーテッド |
Cd20およびnogo遺伝子発現の調節および診断のための方法および試薬
|
US7102024B1
(en)
*
|
2000-08-01 |
2006-09-05 |
Schwartz David A |
Functional biopolymer modification reagents and uses thereof
|
US8568766B2
(en)
|
2000-08-24 |
2013-10-29 |
Gattadahalli M. Anantharamaiah |
Peptides and peptide mimetics to treat pathologies associated with eye disease
|
US20050209179A1
(en)
*
|
2000-08-30 |
2005-09-22 |
Sirna Therapeutics, Inc. |
RNA interference mediated treatment of Alzheimer's disease using short interfering nucleic acid (siNA)
|
US20080032942A1
(en)
*
|
2000-08-30 |
2008-02-07 |
Mcswiggen James |
RNA interference mediated treatment of Alzheimer's disease using short interfering nucleic acid (siNA)
|
WO2002018405A2
(en)
|
2000-09-01 |
2002-03-07 |
Ribozyme Pharmaceuticals, Incorporated |
Methods for synthesizing nucleosides, nucleoside derivatives and non-nucleoside derivatives
|
US20020150936A1
(en)
*
|
2000-09-01 |
2002-10-17 |
Leonid Beigelman |
Methods for synthesizing nucleosides, nucleoside derivatives and non-nucleoside derivatives
|
EP1354062A2
(en)
*
|
2000-09-13 |
2003-10-22 |
Archemix Corporation |
Target activated nucleic acid biosensor and methods of using same
|
US7125660B2
(en)
|
2000-09-13 |
2006-10-24 |
Archemix Corp. |
Nucleic acid sensor molecules and methods of using same
|
US20110052546A1
(en)
*
|
2000-09-19 |
2011-03-03 |
University Of South Florida |
Inhibition of SHIP to Enhance Stem Cell Harvest and Transplantation
|
WO2009042910A2
(en)
*
|
2007-09-26 |
2009-04-02 |
University Of South Florida |
Ship inhibition to direct hematopoietic stem cells and induce extramedullary hematopoiesis
|
US20020165192A1
(en)
*
|
2000-09-19 |
2002-11-07 |
Kerr William G. |
Control of NK cell function and survival by modulation of ship activity
|
AU9684601A
(en)
|
2000-10-12 |
2002-04-22 |
Univ Rochester |
Compositions that inhibit proliferation of cancer cells
|
EP1386004A4
(en)
|
2001-04-05 |
2005-02-16 |
Ribozyme Pharm Inc |
MODULATION OF GENE EXPRESSION ASSOCIATED WITH INFLAMMATORY PROLIFERATION AND GROWTH OF NEURITIES BY METHODS INVOLVING NUCLEIC ACID
|
US20050233996A1
(en)
*
|
2002-02-20 |
2005-10-20 |
Sirna Therapeutics, Inc. |
RNA interference mediated inhibition of hairless (HR) gene expression using short interfering nucleic acid (siNA)
|
US20040006035A1
(en)
*
|
2001-05-29 |
2004-01-08 |
Dennis Macejak |
Nucleic acid mediated disruption of HIV fusogenic peptide interactions
|
JP4358521B2
(ja)
|
2001-05-18 |
2009-11-04 |
サーナ・セラピューティクス・インコーポレイテッド |
細胞デリバリーのためのコンジュゲートおよび組成物
|
US20050080031A1
(en)
*
|
2001-05-18 |
2005-04-14 |
Sirna Therapeutics, Inc. |
Nucleic acid treatment of diseases or conditions related to levels of Ras, HER2 and HIV
|
US20050119211A1
(en)
*
|
2001-05-18 |
2005-06-02 |
Sirna Therapeutics, Inc. |
RNA mediated inhibition connexin gene expression using short interfering nucleic acid (siNA)
|
US20050227935A1
(en)
*
|
2001-05-18 |
2005-10-13 |
Sirna Therapeutics, Inc. |
RNA interference mediated inhibition of TNF and TNF receptor gene expression using short interfering nucleic acid (siNA)
|
US20050159380A1
(en)
*
|
2001-05-18 |
2005-07-21 |
Sirna Therapeutics, Inc. |
RNA interference mediated inhibition of angiopoietin gene expression using short interfering nucleic acid (siNA)
|
US20070270579A1
(en)
*
|
2001-05-18 |
2007-11-22 |
Sirna Therapeutics, Inc. |
RNA interference mediated inhibition of gene expression using short interfering nucleic acid (siNA)
|
US20050124566A1
(en)
*
|
2001-05-18 |
2005-06-09 |
Sirna Therapeutics, Inc. |
RNA interference mediated inhibition of myostatin gene expression using short interfering nucleic acid (siNA)
|
US20050159376A1
(en)
*
|
2002-02-20 |
2005-07-21 |
Slrna Therapeutics, Inc. |
RNA interference mediated inhibition 5-alpha reductase and androgen receptor gene expression using short interfering nucleic acid (siNA)
|
US20050256068A1
(en)
*
|
2001-05-18 |
2005-11-17 |
Sirna Therapeutics, Inc. |
RNA interference mediated inhibition of stearoyl-CoA desaturase (SCD) gene expression using short interfering nucleic acid (siNA)
|
US20050136436A1
(en)
*
|
2001-05-18 |
2005-06-23 |
Sirna Therapeutics, Inc. |
RNA interference mediated inhibition of G72 and D-amino acid oxidase (DAAO) gene expression using short interfering nucleic acid (siNA)
|
US20050137155A1
(en)
*
|
2001-05-18 |
2005-06-23 |
Sirna Therapeutics, Inc. |
RNA interference mediated treatment of Parkinson disease using short interfering nucleic acid (siNA)
|
US20050119212A1
(en)
*
|
2001-05-18 |
2005-06-02 |
Sirna Therapeutics, Inc. |
RNA interference mediated inhibition of FAS and FASL gene expression using short interfering nucleic acid (siNA)
|
US7109165B2
(en)
|
2001-05-18 |
2006-09-19 |
Sirna Therapeutics, Inc. |
Conjugates and compositions for cellular delivery
|
US20080161256A1
(en)
*
|
2001-05-18 |
2008-07-03 |
Sirna Therapeutics, Inc. |
RNA interference mediated inhibition of gene expression using short interfering nucleic acid (siNA)
|
US20050233997A1
(en)
*
|
2001-05-18 |
2005-10-20 |
Sirna Therapeutics, Inc. |
RNA interference mediated inhibition of matrix metalloproteinase 13 (MMP13) gene expression using short interfering nucleic acid (siNA)
|
US20040219671A1
(en)
*
|
2002-02-20 |
2004-11-04 |
Sirna Therapeutics, Inc. |
RNA interference mediated treatment of parkinson disease using short interfering nucleic acid (siNA)
|
US20050176666A1
(en)
*
|
2001-05-18 |
2005-08-11 |
Sirna Therapeutics, Inc. |
RNA interference mediated inhibition of GPRA and AAA1 gene expression using short interfering nucleic acid (siNA)
|
US20040209831A1
(en)
*
|
2002-02-20 |
2004-10-21 |
Mcswiggen James |
RNA interference mediated inhibition of hepatitis C virus (HCV) gene expression using short interfering nucleic acid (siNA)
|
US20050164966A1
(en)
*
|
2001-05-18 |
2005-07-28 |
Sirna Therapeutics, Inc. |
RNA interference mediated inhibition of type 1 insulin-like growth factor receptor gene expression using short interfering nucleic acid (siNA)
|
US20050124567A1
(en)
*
|
2001-05-18 |
2005-06-09 |
Sirna Therapeutics, Inc. |
RNA interference mediated inhibition of TRPM7 gene expression using short interfering nucleic acid (siNA)
|
US20050176664A1
(en)
*
|
2001-05-18 |
2005-08-11 |
Sirna Therapeutics, Inc. |
RNA interference mediated inhibition of cholinergic muscarinic receptor (CHRM3) gene expression using short interfering nucleic acid (siNA)
|
US20060241075A1
(en)
*
|
2001-05-18 |
2006-10-26 |
Sirna Therapeutics, Inc. |
RNA interference mediated inhibition of desmoglein gene expression using short interfering nucleic acid (siNA)
|
US20050159382A1
(en)
*
|
2001-05-18 |
2005-07-21 |
Sirna Therapeutics, Inc. |
RNA interference mediated inhibition of polycomb group protein EZH2 gene expression using short interfering nucleic acid (siNA)
|
US20070042983A1
(en)
*
|
2001-05-18 |
2007-02-22 |
Sirna Therapeutics, Inc. |
RNA interference mediated inhibition of gene expression using short interfering nucleic acid (siNA)
|
US20050124568A1
(en)
*
|
2001-05-18 |
2005-06-09 |
Sirna Therapeutics, Inc. |
RNA interference mediated inhibition of acetyl-CoA-carboxylase gene expression using short interfering nucleic acid (siNA)
|
US20050176665A1
(en)
*
|
2001-05-18 |
2005-08-11 |
Sirna Therapeutics, Inc. |
RNA interference mediated inhibition of hairless (HR) gene expression using short interfering nucleic acid (siNA)
|
US20050182007A1
(en)
*
|
2001-05-18 |
2005-08-18 |
Sirna Therapeutics, Inc. |
RNA interference mediated inhibition of interleukin and interleukin receptor gene expression using short interfering nucleic acid (SINA)
|
US20040198682A1
(en)
*
|
2001-11-30 |
2004-10-07 |
Mcswiggen James |
RNA interference mediated inhibition of placental growth factor gene expression using short interfering nucleic acid (siNA)
|
US20050164224A1
(en)
*
|
2001-05-18 |
2005-07-28 |
Sirna Therapeutics, Inc. |
RNA interference mediated inhibition of cyclin D1 gene expression using short interfering nucleic acid (siNA)
|
US20050287128A1
(en)
*
|
2001-05-18 |
2005-12-29 |
Sirna Therapeutics, Inc. |
RNA interference mediated inhibition of TGF-beta and TGF-beta receptor gene expression using short interfering nucleic acid (siNA)
|
US20050187174A1
(en)
*
|
2001-05-18 |
2005-08-25 |
Sirna Therapeutics, Inc. |
RNA interference mediated inhibition of intercellular adhesion molecule (ICAM) gene expression using short interfering nucleic acid (siNA)
|
US20050209180A1
(en)
*
|
2001-05-18 |
2005-09-22 |
Sirna Therapeutics, Inc. |
RNA interference mediated inhibition of hepatitis C virus (HCV) expression using short interfering nucleic acid (siNA)
|
US20050191638A1
(en)
*
|
2002-02-20 |
2005-09-01 |
Sirna Therapeutics, Inc. |
RNA interference mediated treatment of polyglutamine (polyQ) repeat expansion diseases using short interfering nucleic acid (siNA)
|
US20080188430A1
(en)
*
|
2001-05-18 |
2008-08-07 |
Sirna Therapeutics, Inc. |
RNA interference mediated inhibition of hypoxia inducible factor 1 (HIF1) gene expression using short interfering nucleic acid (siNA)
|
US20050130181A1
(en)
*
|
2001-05-18 |
2005-06-16 |
Sirna Therapeutics, Inc. |
RNA interference mediated inhibition of wingless gene expression using short interfering nucleic acid (siNA)
|
US20050288242A1
(en)
*
|
2001-05-18 |
2005-12-29 |
Sirna Therapeutics, Inc. |
RNA interference mediated inhibition of RAS gene expression using short interfering nucleic acid (siNA)
|
US20050203040A1
(en)
*
|
2001-05-18 |
2005-09-15 |
Sirna Therapeutics, Inc. |
RNA interference mediated inhibition of vascular cell adhesion molecule (VCAM) gene expression using short interfering nucleic acid (siNA)
|
US20050164967A1
(en)
*
|
2001-05-18 |
2005-07-28 |
Sirna Therapeutics, Inc. |
RNA interference mediated inhibition of platelet-derived endothelial cell growth factor (ECGF1) gene expression using short interfering nucleic acid (siNA)
|
US20060211642A1
(en)
*
|
2001-05-18 |
2006-09-21 |
Sirna Therapeutics, Inc. |
RNA inteference mediated inhibition of hepatitis C virus (HVC) gene expression using short interfering nucleic acid (siNA)
|
US7517864B2
(en)
*
|
2001-05-18 |
2009-04-14 |
Sirna Therapeutics, Inc. |
RNA interference mediated inhibition of vascular endothelial growth factor and vascular endothelial growth factor receptor gene expression using short interfering nucleic acid (siNA)
|
US20050153914A1
(en)
*
|
2001-05-18 |
2005-07-14 |
Sirna Therapeutics, Inc. |
RNA interference mediated inhibition of MDR P-glycoprotein gene expression using short interfering nucleic acid (siNA)
|
US20050164968A1
(en)
*
|
2001-05-18 |
2005-07-28 |
Sirna Therapeutics, Inc. |
RNA interference mediated inhibition of ADAM33 gene expression using short interfering nucleic acid (siNA)
|
US20050148530A1
(en)
|
2002-02-20 |
2005-07-07 |
Sirna Therapeutics, Inc. |
RNA interference mediated inhibition of vascular endothelial growth factor and vascular endothelial growth factor receptor gene expression using short interfering nucleic acid (siNA)
|
US20060019913A1
(en)
*
|
2001-05-18 |
2006-01-26 |
Sirna Therapeutics, Inc. |
RNA interference mediated inhibtion of protein tyrosine phosphatase-1B (PTP-1B) gene expression using short interfering nucleic acid (siNA)
|
US20050196765A1
(en)
*
|
2001-05-18 |
2005-09-08 |
Sirna Therapeutics, Inc. |
RNA interference mediated inhibition of checkpoint Kinase-1 (CHK-1) gene expression using short interfering nucleic acid (siNA)
|
US9994853B2
(en)
|
2001-05-18 |
2018-06-12 |
Sirna Therapeutics, Inc. |
Chemically modified multifunctional short interfering nucleic acid molecules that mediate RNA interference
|
US20050079610A1
(en)
*
|
2001-05-18 |
2005-04-14 |
Sirna Therapeutics, Inc. |
RNA interference mediated inhibition of Fos gene expression using short interfering nucleic acid (siNA)
|
US20050196767A1
(en)
*
|
2001-05-18 |
2005-09-08 |
Sirna Therapeutics, Inc. |
RNA interference mediated inhibition of GRB2 associated binding protein (GAB2) gene expression using short interfering nucleic acis (siNA)
|
US20050143333A1
(en)
*
|
2001-05-18 |
2005-06-30 |
Sirna Therapeutics, Inc. |
RNA interference mediated inhibition of interleukin and interleukin receptor gene expression using short interfering nucleic acid (SINA)
|
US20050054598A1
(en)
*
|
2002-02-20 |
2005-03-10 |
Sirna Therapeutics, Inc. |
RNA interference mediated inhibition hairless (HR) gene expression using short interfering nucleic acid (siNA)
|
US20050182009A1
(en)
*
|
2001-05-18 |
2005-08-18 |
Sirna Therapeutics, Inc. |
RNA interference mediated inhibition of NF-Kappa B / REL-A gene expression using short interfering nucleic acid (siNA)
|
US20050014172A1
(en)
*
|
2002-02-20 |
2005-01-20 |
Ivan Richards |
RNA interference mediated inhibition of muscarinic cholinergic receptor gene expression using short interfering nucleic acid (siNA)
|
US20050182006A1
(en)
*
|
2001-05-18 |
2005-08-18 |
Sirna Therapeutics, Inc |
RNA interference mediated inhibition of protein kinase C alpha (PKC-alpha) gene expression using short interfering nucleic acid (siNA)
|
US20050222066A1
(en)
*
|
2001-05-18 |
2005-10-06 |
Sirna Therapeutics, Inc. |
RNA interference mediated inhibition of vascular endothelial growth factor and vascular endothelial growth factor receptor gene expression using short interfering nucleic acid (siNA)
|
US20060142225A1
(en)
*
|
2001-05-18 |
2006-06-29 |
Sirna Therapeutics, Inc. |
RNA interference mediated inhibition of cyclin dependent kinase-2 (CDK2) gene expression using short interfering nucleic acid (siNA)
|
US20050282188A1
(en)
*
|
2001-05-18 |
2005-12-22 |
Sirna Therapeutics, Inc. |
RNA interference mediated inhibition of gene expression using short interfering nucleic acid (siNA)
|
US20050054596A1
(en)
*
|
2001-11-30 |
2005-03-10 |
Mcswiggen James |
RNA interference mediated inhibition of vascular endothelial growth factor and vascular endothelial growth factor receptor gene expression using short interfering nucleic acid (siNA)
|
US20060142226A1
(en)
*
|
2001-05-18 |
2006-06-29 |
Sirna Therapeutics, Inc. |
RNA interference mediated inhibition of cholesteryl ester transfer protein (CETP) gene expression using short interfering nucleic acid (siNA)
|
US20050159379A1
(en)
*
|
2001-05-18 |
2005-07-21 |
Sirna Therapeutics, Inc |
RNA interference mediated inhibition of gastric inhibitory polypeptide (GIP) and gastric inhibitory polypeptide receptor (GIPR) gene expression using short interfering nucleic acid (siNA)
|
US20050233344A1
(en)
*
|
2001-05-18 |
2005-10-20 |
Sirna Therapeutics, Inc. |
RNA interference mediated inhibition of platelet derived growth factor (PDGF) and platelet derived growth factor receptor (PDGFR) gene expression using short interfering nucleic acid (siNA)
|
US20050267058A1
(en)
*
|
2001-05-18 |
2005-12-01 |
Sirna Therapeutics, Inc. |
RNA interference mediated inhibition of placental growth factor gene expression using short interfering nucleic acid (sINA)
|
US20050153915A1
(en)
*
|
2001-05-18 |
2005-07-14 |
Sirna Therapeutics, Inc. |
RNA interference mediated inhibition of early growth response gene expression using short interfering nucleic acid (siNA)
|
US8114418B2
(en)
|
2001-06-21 |
2012-02-14 |
Dynavax Technologies Corporation |
Chimeric immunomodulatory compounds and methods of using the same—IV
|
US7785610B2
(en)
*
|
2001-06-21 |
2010-08-31 |
Dynavax Technologies Corporation |
Chimeric immunomodulatory compounds and methods of using the same—III
|
US20040126867A1
(en)
*
|
2001-07-06 |
2004-07-01 |
Crooke Stanley T. |
Human RNase III and compositions and uses thereof
|
DE10150121B4
(de)
*
|
2001-10-11 |
2005-12-01 |
Bernhard-Nocht-Institut für Tropenmedizin |
Echtzeitdetektion von DNA-Amplifikationsprodukten
|
US20050075304A1
(en)
*
|
2001-11-30 |
2005-04-07 |
Mcswiggen James |
RNA interference mediated inhibition of vascular endothelial growth factor and vascular endothelial growth factor receptor gene expression using short interfering nucleic acid (siNA)
|
US20040138163A1
(en)
*
|
2002-05-29 |
2004-07-15 |
Mcswiggen James |
RNA interference mediated inhibition of vascular edothelial growth factor and vascular edothelial growth factor receptor gene expression using short interfering nucleic acid (siNA)
|
US20070203333A1
(en)
*
|
2001-11-30 |
2007-08-30 |
Mcswiggen James |
RNA interference mediated inhibition of vascular endothelial growth factor and vascular endothelial growth factor receptor gene expression using short interfering nucleic acid (siNA)
|
WO2003064621A2
(en)
*
|
2002-02-01 |
2003-08-07 |
Ambion, Inc. |
HIGH POTENCY siRNAS FOR REDUCING THE EXPRESSION OF TARGET GENES
|
US20060009409A1
(en)
|
2002-02-01 |
2006-01-12 |
Woolf Tod M |
Double-stranded oligonucleotides
|
EP1478656B1
(en)
|
2002-02-01 |
2009-09-16 |
Life Technologies Corporation |
Oligonucleotide compositions with enhanced efficiency
|
KR20100094569A
(ko)
|
2002-02-06 |
2010-08-26 |
비코르 테크놀로지스 인코포레이티드 |
경색방지 분자
|
AU2003207708A1
(en)
|
2002-02-20 |
2003-09-09 |
Sirna Therapeutics, Inc. |
Rna interference mediated inhibition of map kinase genes
|
US20050137153A1
(en)
*
|
2002-02-20 |
2005-06-23 |
Sirna Therapeutics, Inc. |
RNA interference mediated inhibition of alpha-1 antitrypsin (AAT) gene expression using short interfering nucleic acid (siNA)
|
US20050222064A1
(en)
*
|
2002-02-20 |
2005-10-06 |
Sirna Therapeutics, Inc. |
Polycationic compositions for cellular delivery of polynucleotides
|
US9181551B2
(en)
|
2002-02-20 |
2015-11-10 |
Sirna Therapeutics, Inc. |
RNA interference mediated inhibition of gene expression using chemically modified short interfering nucleic acid (siNA)
|
WO2003070966A2
(en)
*
|
2002-02-20 |
2003-08-28 |
Sirna Therapeutics, Inc |
RNA INTERFERENCE MEDIATED TARGET DISCOVERY AND TARGET VALIDATION USING SHORT INTERFERING NUCLEIC ACID (siNA)
|
US9657294B2
(en)
|
2002-02-20 |
2017-05-23 |
Sirna Therapeutics, Inc. |
RNA interference mediated inhibition of gene expression using chemically modified short interfering nucleic acid (siNA)
|
WO2003106476A1
(en)
*
|
2002-02-20 |
2003-12-24 |
Sirna Therapeutics, Inc |
Nucleic acid mediated inhibition of enterococcus infection and cytolysin toxin activity
|
US20050096284A1
(en)
*
|
2002-02-20 |
2005-05-05 |
Sirna Therapeutics, Inc. |
RNA interference mediated treatment of polyglutamine (polyQ) repeat expansion diseases using short interfering nucleic acid (siNA)
|
WO2003093452A2
(en)
*
|
2002-02-26 |
2003-11-13 |
University Of Utah Research Foundation |
Variants of nedd4l associated with hypertension and viral budding
|
US20040248094A1
(en)
*
|
2002-06-12 |
2004-12-09 |
Ford Lance P. |
Methods and compositions relating to labeled RNA molecules that reduce gene expression
|
WO2003106631A2
(en)
*
|
2002-06-12 |
2003-12-24 |
Ambion, Inc. |
Methods and compositions relating to labeled rna molecules that reduce gene expression
|
US20100075423A1
(en)
*
|
2002-06-12 |
2010-03-25 |
Life Technologies Corporation |
Methods and compositions relating to polypeptides with rnase iii domains that mediate rna interference
|
AU2003247827A1
(en)
*
|
2002-06-28 |
2004-01-19 |
Rosetta Inpharmactis Llc |
Methods to assess quality of microarrays
|
US7655790B2
(en)
*
|
2002-07-12 |
2010-02-02 |
Sirna Therapeutics, Inc. |
Deprotection and purification of oligonucleotides and their derivatives
|
US6989442B2
(en)
*
|
2002-07-12 |
2006-01-24 |
Sirna Therapeutics, Inc. |
Deprotection and purification of oligonucleotides and their derivatives
|
US20050287648A1
(en)
|
2002-08-05 |
2005-12-29 |
University Of Rochester |
Protein Transducing Domain/Deaminase Chimeric Proteins, Related Compounds, and Uses Thereof
|
AU2003256857A1
(en)
*
|
2002-08-08 |
2004-02-25 |
Dharmacon, Inc. |
Short interfering rnas having a hairpin structure containing a non-nucleotide loop
|
US20040029275A1
(en)
*
|
2002-08-10 |
2004-02-12 |
David Brown |
Methods and compositions for reducing target gene expression using cocktails of siRNAs or constructs expressing siRNAs
|
CN100471486C
(zh)
|
2002-08-12 |
2009-03-25 |
戴纳伐克斯技术股份有限公司 |
免疫调节组合物,其制备方法和使用方法
|
US7956176B2
(en)
|
2002-09-05 |
2011-06-07 |
Sirna Therapeutics, Inc. |
RNA interference mediated inhibition of gene expression using chemically modified short interfering nucleic acid (siNA)
|
AU2003268531A1
(en)
|
2002-09-06 |
2004-03-29 |
University Of South Florida |
Materials and methods for treatment of allergic diseases
|
US20080214437A1
(en)
*
|
2002-09-06 |
2008-09-04 |
Mohapatra Shyam S |
Methods and compositions for reducing activity of the atrial natriuretic peptide receptor and for treatment of diseases
|
JP2006508927A
(ja)
*
|
2002-09-19 |
2006-03-16 |
メルク エンド カムパニー インコーポレーテッド |
エストロゲン受容体修飾因子
|
US20040242518A1
(en)
*
|
2002-09-28 |
2004-12-02 |
Massachusetts Institute Of Technology |
Influenza therapeutic
|
WO2004044138A2
(en)
|
2002-11-05 |
2004-05-27 |
Isis Pharmaceuticals, Inc. |
Chimeric oligomeric compounds and their use in gene modulation
|
AU2003290596B2
(en)
|
2002-11-05 |
2011-05-12 |
Isis Pharmaceuticals, Inc. |
Sugar surrogate-containing oligomeric compounds and compositions for use in gene modulation
|
US20040231231A1
(en)
*
|
2002-12-20 |
2004-11-25 |
Cataldo Dominic A. |
Use of colloidal clays for sustained release of active ingredients
|
EP1625140A4
(en)
*
|
2002-12-23 |
2008-06-18 |
Dynavax Tech Corp |
BRANCHED IMMUNOMODULAR COMPOUNDS AND METHOD OF USE THEREOF
|
WO2004093788A2
(en)
*
|
2003-04-17 |
2004-11-04 |
The Trustees Of Columbia University In The City Ofnew York |
Desmoglein 4 is a novel gene involved in hair growth
|
EP1622572B1
(en)
|
2003-04-30 |
2017-12-20 |
Sirna Therapeutics, Inc. |
Conjugates and compositions for cellular delivery
|
WO2005044976A2
(en)
*
|
2003-06-20 |
2005-05-19 |
Isis Pharmaceuticals, Inc. |
Oligomeric compounds for use in gene modulation
|
US7807646B1
(en)
*
|
2003-11-20 |
2010-10-05 |
University Of South Florida |
SHIP-deficiency to increase megakaryocyte progenitor production
|
EP1727556A2
(en)
*
|
2004-02-17 |
2006-12-06 |
University Of South Florida |
Materials and methods for treatment of inflammatory and cell proliferation disorders
|
EP1716234B1
(de)
*
|
2004-02-20 |
2013-10-02 |
Mologen AG |
Substituiertes, nicht-kodierendes nukleinsäuremolekül zur therapeutischen und prophylaktischen immunstimulation in menschen und höheren tieren
|
US8569474B2
(en)
|
2004-03-09 |
2013-10-29 |
Isis Pharmaceuticals, Inc. |
Double stranded constructs comprising one or more short strands hybridized to a longer strand
|
US20050267300A1
(en)
*
|
2004-04-05 |
2005-12-01 |
Muthiah Manoharan |
Processes and reagents for oligonucleotide synthesis and purification
|
AU2005238034A1
(en)
|
2004-04-23 |
2005-11-10 |
The Trustees Of Columbia University In The City Of New York |
Inhibition of hairless protein mRNA
|
CA2562685C
(en)
*
|
2004-04-27 |
2013-09-17 |
Alnylam Pharmaceuticals, Inc. |
Single-stranded and double-stranded oligonucleotides comprising a 2-arylpropyl moiety
|
JP4584987B2
(ja)
*
|
2004-04-30 |
2010-11-24 |
アルニラム ファーマスーティカルズ インコーポレイテッド |
C5修飾ピリミジンを含むオリゴヌクレオチド
|
US20060040882A1
(en)
|
2004-05-04 |
2006-02-23 |
Lishan Chen |
Compostions and methods for enhancing delivery of nucleic acids into cells and for modifying expression of target genes in cells
|
US10508277B2
(en)
|
2004-05-24 |
2019-12-17 |
Sirna Therapeutics, Inc. |
Chemically modified multifunctional short interfering nucleic acid molecules that mediate RNA interference
|
US8394947B2
(en)
|
2004-06-03 |
2013-03-12 |
Isis Pharmaceuticals, Inc. |
Positionally modified siRNA constructs
|
WO2005121372A2
(en)
*
|
2004-06-03 |
2005-12-22 |
Isis Pharmaceuticals, Inc. |
Double strand compositions comprising differentially modified strands for use in gene modulation
|
JP2008504840A
(ja)
*
|
2004-06-30 |
2008-02-21 |
アルニラム ファーマスーティカルズ インコーポレイテッド |
非リン酸骨格結合を含むオリゴヌクレオチド
|
WO2006093526A2
(en)
|
2004-07-21 |
2006-09-08 |
Alnylam Pharmaceuticals, Inc. |
Oligonucleotides comprising a modified or non-natural nucleobase
|
US7632932B2
(en)
|
2004-08-04 |
2009-12-15 |
Alnylam Pharmaceuticals, Inc. |
Oligonucleotides comprising a ligand tethered to a modified or non-natural nucleobase
|
EP1794174B1
(en)
*
|
2004-09-01 |
2012-06-06 |
Dynavax Technologies Corporation |
Methods and compositions for inhibition of innate immune responses and autoimmunity
|
US7884086B2
(en)
|
2004-09-08 |
2011-02-08 |
Isis Pharmaceuticals, Inc. |
Conjugates for use in hepatocyte free uptake assays
|
EP1836218A2
(en)
*
|
2004-12-17 |
2007-09-26 |
Dynavax Technologies Corporation |
Methods and compositions for induction or promotion of immune tolerance
|
US20060142228A1
(en)
*
|
2004-12-23 |
2006-06-29 |
Ambion, Inc. |
Methods and compositions concerning siRNA's as mediators of RNA interference
|
BRPI0606791A2
(pt)
|
2005-02-02 |
2010-02-09 |
Uab Research Foundation |
métodos de reverter ou prevenir a resistência de uma célula a um agonista do receptor da morte, de triar uma célula quanto a um biomarcador da resistência a um agonista do receptor da morte, de monitorar a resistência a um agonista do receptor da morte em um indivìduo, de induzir seletivamente a apoptose em uma célula alvo expressando um receptor da morte, de tratar de um indivìduo com cáncer, de tratar de um indivìduo com uma doença inflamatória ou autoimune, de bloquear a ligação da proteìna contendo card a um receptor da morte em uma célula, de bloquear a associação de um iap com o receptor da morte e de triar um modulador de uma proteìna contendo card, composição, ácido nucleico isolado, vetor, célula, e, polipeptìdeo isolado
|
WO2006099875A1
(en)
|
2005-03-23 |
2006-09-28 |
Genmab A/S |
Antibodies against cd38 for treatment of multiple myeloma
|
US7476733B2
(en)
*
|
2005-03-25 |
2009-01-13 |
The United States Of America As Represented By The Department Of Health And Human Services |
Development of a real-time PCR assay for detection of pneumococcal DNA and diagnosis of pneumococccal disease
|
WO2006113743A2
(en)
*
|
2005-04-18 |
2006-10-26 |
Massachusetts Institute Of Technology |
Compositions and methods for rna interference with sialidase expression and uses thereof
|
WO2006138145A1
(en)
|
2005-06-14 |
2006-12-28 |
Northwestern University |
Nucleic acid functionalized nanoparticles for therapeutic applications
|
WO2007015348A1
(ja)
|
2005-08-04 |
2007-02-08 |
Sharp Kabushiki Kaisha |
液晶表示装置およびその駆動方法
|
US20090176725A1
(en)
*
|
2005-08-17 |
2009-07-09 |
Sirna Therapeutics Inc. |
Chemically modified short interfering nucleic acid molecules that mediate rna interference
|
WO2007044607A2
(en)
*
|
2005-10-06 |
2007-04-19 |
Emthrax, Llc |
Methods and compositions relating to anthrax spore glycoproteins as vaccines
|
US8080534B2
(en)
|
2005-10-14 |
2011-12-20 |
Phigenix, Inc |
Targeting PAX2 for the treatment of breast cancer
|
EP2392647A1
(en)
|
2005-10-14 |
2011-12-07 |
MUSC Foundation For Research Development |
Targeting PAX2 for the induction of DEFB1-mediated tumor immunity and cancer therapy
|
EP3357490A1
(en)
|
2006-04-28 |
2018-08-08 |
Children's Hospital Medical Center |
Fusogenic properties of saposin c and related proteins and polypeptides for application to transmembrane drug delivery systems
|
CA2656990A1
(en)
*
|
2006-04-28 |
2007-11-08 |
University Of South Florida |
Materials and methods for reducing inflammation by inhibition of the atrial natriuretic peptide receptor
|
US20100190689A1
(en)
|
2006-09-21 |
2010-07-29 |
University Of Rochester |
Compositions and methods related to protein displacement therapy for myotonic distrophy
|
EP2104516B1
(en)
|
2006-11-01 |
2015-01-07 |
University of Rochester |
Methods and compositions related to the structure and function of apobec3g
|
BRPI0720038A2
(pt)
|
2006-12-11 |
2013-12-24 |
Univ Utah Res Found |
Métodos para inibir a permeabilidade vascular em tecido, para triar ou avaliar um agente que inibe a permeabilidade vascular, para tratar ou prevenir a síndrome da angústia respiratória, a retinopatia de prematuridade, a retinopatia diabética e a degeneração macular úmida em um indivíduo, para tratar indivíduos com sugestões repulsivas ou miméticos e para promover a angiogênese em um tecido, polipeptídeo isolado, ácido nucleico isolado, e, vetor
|
US7951789B2
(en)
|
2006-12-28 |
2011-05-31 |
Idenix Pharmaceuticals, Inc. |
Compounds and pharmaceutical compositions for the treatment of viral infections
|
US8507200B2
(en)
|
2007-02-09 |
2013-08-13 |
Northwestern University |
Particles for detecting intracellular targets
|
EP2124988B1
(en)
|
2007-02-23 |
2014-11-12 |
The Trustees of Columbia University in the City of New York |
Methods to activate or block the hla-e/qa-1 restricted cd8+ t cell regulatory pathway to treat immunological disease
|
WO2008104978A2
(en)
*
|
2007-02-28 |
2008-09-04 |
Quark Pharmaceuticals, Inc. |
Novel sirna structures
|
EP3434259A1
(en)
|
2007-05-04 |
2019-01-30 |
Marina Biotech, Inc. |
Amino acid lipids and uses thereof
|
WO2008151049A2
(en)
|
2007-05-30 |
2008-12-11 |
Northwestern University |
Nucleic acid functionalized nanoparticles for therapeutic applications
|
CA2697957A1
(en)
|
2007-08-28 |
2009-03-12 |
Uab Research Foundation |
Synthetic apolipoprotein e mimicking polypeptides and methods of use
|
US9422363B2
(en)
|
2007-08-28 |
2016-08-23 |
Uab Research Foundation |
Synthetic apolipoprotein E mimicking polypeptides and methods of use
|
AU2008306455C1
(en)
*
|
2007-10-03 |
2014-04-17 |
Quark Pharmaceuticals, Inc. |
Novel siRNA structures
|
EP2361980B1
(en)
|
2007-10-26 |
2016-12-07 |
Dynavax Technologies Corporation |
Methods and compositions for inhibition of immune responses and autoimmunity
|
EP2268664B1
(en)
*
|
2007-12-03 |
2017-05-24 |
The Government of the United States of America as represented by the Secretary of the Department of Health and Human Services |
Doc1 compositions and methods for treating cancer
|
US8614311B2
(en)
|
2007-12-12 |
2013-12-24 |
Quark Pharmaceuticals, Inc. |
RTP801L siRNA compounds and methods of use thereof
|
US20110105584A1
(en)
*
|
2007-12-12 |
2011-05-05 |
Elena Feinstein |
Rtp80il sirna compounds and methods of use thereof
|
WO2009090639A2
(en)
*
|
2008-01-15 |
2009-07-23 |
Quark Pharmaceuticals, Inc. |
Sirna compounds and methods of use thereof
|
US10131904B2
(en)
*
|
2008-02-11 |
2018-11-20 |
Rxi Pharmaceuticals Corporation |
Modified RNAi polynucleotides and uses thereof
|
US20090233993A1
(en)
*
|
2008-03-06 |
2009-09-17 |
Burnham Institute For Medical Research |
Compositions and methods for inhibiting gsk3 activity and uses thereof
|
EP2268316A4
(en)
*
|
2008-03-20 |
2011-05-25 |
Quark Pharmaceuticals Inc |
NEW SIRNA COMPOUNDS FOR INHIBITING RTP801
|
WO2009144704A2
(en)
*
|
2008-04-15 |
2009-12-03 |
Quark Pharmaceuticals, Inc. |
siRNA COMPOUNDS FOR INHIBITING NRF2
|
EP2288922B1
(en)
|
2008-05-08 |
2016-08-17 |
University of Utah Research Foundation |
Sensory receptors for chronic fatigue and pain and uses thereof
|
WO2009137095A2
(en)
|
2008-05-08 |
2009-11-12 |
The Johns Hopkins University |
Compositions and methods for modulating an immune response
|
EP2296669B1
(en)
|
2008-05-30 |
2012-03-21 |
Yale University |
Targeted oligonucleotide compositions for modifying gene expression
|
CA2729168A1
(en)
*
|
2008-07-02 |
2010-02-04 |
Idenix Pharmaceuticals, Inc. |
Compounds and pharmaceutical compositions for the treatment of viral infections
|
WO2010008582A2
(en)
|
2008-07-18 |
2010-01-21 |
Rxi Pharmaceuticals Corporation |
Phagocytic cell drug delivery system
|
AU2009293658A1
(en)
|
2008-09-22 |
2010-03-25 |
James Cardia |
Reduced size self-delivering RNAi compounds
|
KR20110071017A
(ko)
|
2008-10-16 |
2011-06-27 |
마리나 바이오테크, 인크. |
유전자 침묵 치료제의 리포좀에 의한 효율적인 전달을 위한 프로세스 및 조성물
|
WO2010059226A2
(en)
|
2008-11-19 |
2010-05-27 |
Rxi Pharmaceuticals Corporation |
Inhibition of map4k4 through rnai
|
KR101692880B1
(ko)
|
2008-11-24 |
2017-01-04 |
노오쓰웨스턴 유니버시티 |
다가 rna-나노입자 구조체
|
WO2010065617A1
(en)
|
2008-12-02 |
2010-06-10 |
University Of Utah Research Foundation |
Pde1 as a target therapeutic in heart disease
|
WO2010078536A1
(en)
|
2009-01-05 |
2010-07-08 |
Rxi Pharmaceuticals Corporation |
Inhibition of pcsk9 through rnai
|
US20100233270A1
(en)
|
2009-01-08 |
2010-09-16 |
Northwestern University |
Delivery of Oligonucleotide-Functionalized Nanoparticles
|
US9745574B2
(en)
|
2009-02-04 |
2017-08-29 |
Rxi Pharmaceuticals Corporation |
RNA duplexes with single stranded phosphorothioate nucleotide regions for additional functionality
|
US20110038871A1
(en)
|
2009-08-11 |
2011-02-17 |
Veena Viswanth |
Ccr2 inhibitors for treating conditions of the eye
|
WO2011031974A1
(en)
|
2009-09-10 |
2011-03-17 |
Southern Research Institute |
Acridine analogs in the treatment of gliomas
|
KR20120136345A
(ko)
|
2009-10-30 |
2012-12-18 |
노오쓰웨스턴 유니버시티 |
주형화된 나노컨쥬게이트
|
JP2013511990A
(ja)
|
2009-11-26 |
2013-04-11 |
クォーク ファーマシューティカルズ インコーポレーティッド |
末端置換を含むsiRNA化合物
|
EP3012324A3
(en)
|
2009-12-09 |
2016-07-06 |
Nitto Denko Corporation |
Modulation of hsp47 expression
|
WO2011084193A1
(en)
|
2010-01-07 |
2011-07-14 |
Quark Pharmaceuticals, Inc. |
Oligonucleotide compounds comprising non-nucleotide overhangs
|
US20110207789A1
(en)
|
2010-02-19 |
2011-08-25 |
Ye Fang |
Methods related to casein kinase ii (ck2) inhibitors and the use of purinosome-disrupting ck2 inhibitors for anti-cancer therapy agents
|
US9080171B2
(en)
|
2010-03-24 |
2015-07-14 |
RXi Parmaceuticals Corporation |
Reduced size self-delivering RNAi compounds
|
CN105131067B
(zh)
|
2010-03-24 |
2019-02-19 |
雷克西制药公司 |
皮肤与纤维化症候中的rna干扰
|
CN106074591B
(zh)
|
2010-03-24 |
2020-01-14 |
菲奥医药公司 |
眼部症候中的rna干扰
|
WO2011120023A1
(en)
|
2010-03-26 |
2011-09-29 |
Marina Biotech, Inc. |
Nucleic acid compounds for inhibiting survivin gene expression uses thereof
|
CA2795054A1
(en)
|
2010-04-01 |
2011-10-06 |
Idenix Pharmaceuticals, Inc. |
Compounds and pharmaceutical compositions for the treatment of viral infections
|
US9145556B2
(en)
|
2010-04-13 |
2015-09-29 |
Life Technologies Corporation |
Compositions and methods for inhibition of nucleic acids function
|
WO2011133584A2
(en)
|
2010-04-19 |
2011-10-27 |
Marina Biotech, Inc. |
Nucleic acid compounds for inhibiting hras gene expression and uses thereof
|
US20130190383A1
(en)
|
2010-04-26 |
2013-07-25 |
Marina Biotech, Inc. |
Nucleic acid compounds with conformationally restricted monomers and uses thereof
|
WO2011139843A2
(en)
|
2010-04-28 |
2011-11-10 |
Marina Biotech, Inc. |
Multi-sirna compositions for reducing gene expression
|
SG186380A1
(en)
|
2010-06-16 |
2013-01-30 |
Dynavax Tech Corp |
Methods of treatment using tlr7 and/or tlr9 inhibitors
|
CN103140582A
(zh)
|
2010-08-24 |
2013-06-05 |
默沙东公司 |
含有内部非核酸间隔子的单链RNAi试剂
|
ES2663009T3
(es)
|
2010-10-29 |
2018-04-10 |
Sirna Therapeutics, Inc. |
Inhibición de la expresión génica mediada por interferencia por ARN utilizando ácidos nucleicos de interferencia cortos (ANic)
|
WO2012118910A2
(en)
|
2011-03-03 |
2012-09-07 |
Quark Pharmaceuticals, Inc. |
Compositions and methods for treating lung disease and injury
|
US10184942B2
(en)
|
2011-03-17 |
2019-01-22 |
University Of South Florida |
Natriuretic peptide receptor as a biomarker for diagnosis and prognosis of cancer
|
WO2012154321A1
(en)
|
2011-03-31 |
2012-11-15 |
Idenix Pharmaceuticals, Inc. |
Compounds and pharmaceutical compositions for the treatment of viral infections
|
US10196637B2
(en)
|
2011-06-08 |
2019-02-05 |
Nitto Denko Corporation |
Retinoid-lipid drug carrier
|
TWI658830B
(zh)
|
2011-06-08 |
2019-05-11 |
日東電工股份有限公司 |
Hsp47表現調控強化用類視色素脂質體
|
SG11201401314PA
(en)
|
2011-09-07 |
2014-09-26 |
Marina Biotech Inc |
Synthesis and uses of nucleic acid compounds with conformationally restricted monomers
|
US9403863B2
(en)
|
2011-09-12 |
2016-08-02 |
Idenix Pharmaceuticals Llc |
Substituted carbonyloxymethylphosphoramidate compounds and pharmaceutical compositions for the treatment of viral infections
|
CA2847698C
(en)
|
2011-09-14 |
2020-09-01 |
Northwestern University |
Nanoconjugates able to cross the blood-brain barrier
|
EP3960726A1
(en)
|
2011-10-18 |
2022-03-02 |
Dicerna Pharmaceuticals, Inc. |
Amine cationic lipids and uses thereof
|
DK2877490T3
(en)
|
2012-06-27 |
2018-12-17 |
Univ Princeton |
SPLIT INTEINS, CONJUGATES AND APPLICATIONS THEREOF
|
CA2878314A1
(en)
|
2012-07-16 |
2014-01-23 |
Kyowa Hakko Kirin Co., Ltd. |
Rnai pharmaceutical composition for suppressing expression of kras gene
|
WO2014043291A1
(en)
|
2012-09-12 |
2014-03-20 |
Quark Pharmaceuticals, Inc. |
Double-stranded nucleic acid compounds
|
US9228184B2
(en)
|
2012-09-29 |
2016-01-05 |
Dynavax Technologies Corporation |
Human toll-like receptor inhibitors and methods of use thereof
|
KR102205278B1
(ko)
|
2013-03-14 |
2021-01-22 |
다이서나 파마수이티컬, 인크. |
음이온성 약제를 제형화하는 방법
|
US9765220B2
(en)
*
|
2013-08-22 |
2017-09-19 |
Sony Corporation |
Water soluble fluorescent or colored dyes and methods for their use
|
US10934550B2
(en)
|
2013-12-02 |
2021-03-02 |
Phio Pharmaceuticals Corp. |
Immunotherapy of cancer
|
DK3087184T3
(da)
|
2013-12-27 |
2019-07-29 |
Dicerna Pharmaceuticals Inc |
Fremgangsmåder og sammensætninger til specifik inhibering af glycolatoxidase (hao1) med dobbeltstrenget rna
|
US11279934B2
(en)
|
2014-04-28 |
2022-03-22 |
Phio Pharmaceuticals Corp. |
Methods for treating cancer using nucleic acids targeting MDM2 or MYCN
|
WO2015187966A1
(en)
|
2014-06-04 |
2015-12-10 |
Aurasense Therapeutics, Llc |
Multivalent delivery of immune modulators by liposomal spherical nucleic acids for prophylactic or therapeutic applications
|
CN107074923B
(zh)
|
2014-07-31 |
2021-08-03 |
Uab研究基金会 |
Apoe模拟肽及对清除血浆胆固醇的较高效力
|
US9932566B2
(en)
|
2014-08-07 |
2018-04-03 |
Agilent Technologies, Inc. |
CIS-blocked guide RNA
|
EP3188799B1
(en)
|
2014-09-05 |
2022-07-06 |
Phio Pharmaceuticals Corp. |
Methods for treating aging and skin disorders using nucleic acids targeting tyr or mmp1
|
JP2017537619A
(ja)
|
2014-11-21 |
2017-12-21 |
ノースウェスタン ユニバーシティ |
球状核酸ナノ粒子複合体の配列特異的細胞内取込
|
US10264976B2
(en)
|
2014-12-26 |
2019-04-23 |
The University Of Akron |
Biocompatible flavonoid compounds for organelle and cell imaging
|
JP6983752B2
(ja)
|
2015-07-06 |
2021-12-17 |
フィオ ファーマシューティカルズ コーポレーションPhio Pharmaceuticals Corp. |
スーパーオキシドディスムターゼ1(sod1)を標的とする核酸分子
|
WO2017007825A1
(en)
|
2015-07-06 |
2017-01-12 |
Rxi Pharmaceuticals Corporation |
Methods for treating neurological disorders using a synergistic small molecule and nucleic acids therapeutic approach
|
LU92821B1
(en)
|
2015-09-09 |
2017-03-20 |
Mologen Ag |
Combination comprising immunostimulatory oligonucleotides
|
GB2542425A
(en)
|
2015-09-21 |
2017-03-22 |
Mologen Ag |
Means for the treatment of HIV
|
JP2018531037A
(ja)
|
2015-10-19 |
2018-10-25 |
アールエックスアイ ファーマシューティカルズ コーポレーション |
長い非コードrnaを標的とする減少したサイズの自己送達型核酸化合物
|
EP3386519B1
(en)
|
2015-12-13 |
2021-03-24 |
Nitto Denko Corporation |
Sirna structures for high activity and reduced off target
|
AU2017213404A1
(en)
|
2016-01-29 |
2018-09-20 |
Kyowa Kirin Co., Ltd. |
Nucleic acid conjugate
|
KR102520362B1
(ko)
|
2016-06-30 |
2023-04-10 |
쿄와 기린 가부시키가이샤 |
당쇄 리간드가 링커를 통해 올리고뉴클레오티드와 결합한 핵산 복합체
|
WO2018022925A1
(en)
|
2016-07-29 |
2018-02-01 |
Sony Corporation |
Ultra bright dimeric or polymeric dyes and methods for preparation of the same
|
EP3496736A4
(en)
|
2016-08-03 |
2020-05-13 |
H. Lee Moffitt Cancer Center And Research Institute, Inc. |
THERAPEUTICS AGAINST TLR9
|
WO2018039629A2
(en)
|
2016-08-25 |
2018-03-01 |
Northwestern University |
Micellar spherical nucleic acids from thermoresponsive, traceless templates
|
US12016314B2
(en)
|
2017-09-08 |
2024-06-25 |
Ohio State Innovation Foundation |
MicroRNA inhibitor therapy in systemic lupus erythematosus
|
JPWO2020111280A1
(ja)
|
2018-11-30 |
2021-10-14 |
協和キリン株式会社 |
核酸複合体
|
TW202200163A
(zh)
|
2020-03-18 |
2022-01-01 |
美商戴瑟納製藥股份有限公司 |
用於抑制angptl3表現之組合物及方法
|
TW202221120A
(zh)
|
2020-08-04 |
2022-06-01 |
美商黛瑟納製藥公司 |
用於治療代謝症候群之組成物及方法
|
EP4192478A2
(en)
|
2020-08-04 |
2023-06-14 |
Dicerna Pharmaceuticals, Inc. |
Compositions and methods for inhibiting plp1 expression
|
TW202220673A
(zh)
|
2020-08-05 |
2022-06-01 |
美商戴瑟納製藥股份有限公司 |
抑制lpa表現之組合物及方法
|
AU2022256742A1
(en)
|
2021-04-12 |
2023-09-07 |
Boehringer Ingelheim International Gmbh |
Compositions and methods for inhibiting ketohexokinase (khk)
|
CA3209418A1
(en)
|
2021-04-14 |
2022-10-20 |
Utsav SAXENA |
Compositions and methods for modulating pnpla3 expression
|
US11578329B2
(en)
|
2021-04-19 |
2023-02-14 |
Novo Nordisk A/S |
Compositions and methods for inhibiting nuclear receptor subfamily 1 group H member 3 (NR1H3) expression
|
EP4347820A1
(en)
|
2021-05-28 |
2024-04-10 |
Novo Nordisk A/S |
Compositions and methods for inhibiting mitochondria amidoxime reducing component 1 (marc1) expression
|
AR124636A1
(es)
|
2021-08-25 |
2023-04-19 |
Dicerna Pharmaceuticals Inc |
COMPOSICIONES Y MÉTODOS PARA INHIBIR LA EXPRESIÓN DE a-1 ANTITRIPSINA
|
WO2023092102A1
(en)
|
2021-11-19 |
2023-05-25 |
Sanegene Bio Usa Inc. |
Double stranded rna targeting angiopoietin-like 3 (angptl-3) and methods of use thereof
|
WO2023102469A2
(en)
|
2021-12-01 |
2023-06-08 |
Dicerna Pharmaceuticals, Inc. |
Compositions and methods for modulating apoc3 expression
|
US20230374522A1
(en)
|
2022-04-15 |
2023-11-23 |
Dicerna Pharmaceuticals, Inc. |
Compositions and methods for modulating scap activity
|
US20240002857A1
(en)
|
2022-05-09 |
2024-01-04 |
Sanegene Bio Usa Inc. |
Double stranded rna targeting 17-beta hydroxysteroiddehydrogenase 13 (hsd17b13) and methods of use thereof
|
US20230416742A1
(en)
|
2022-05-12 |
2023-12-28 |
Dicerna Phrmaceuticals, Inc. |
Compositions and methods for inhibiting mapt expression
|
US20230416743A1
(en)
|
2022-05-13 |
2023-12-28 |
Dicerna Pharmaceuticals, Inc. |
Compositions and methods for inhibiting snca expression
|
TW202400193A
(zh)
|
2022-06-24 |
2024-01-01 |
丹麥商諾佛 儂迪克股份有限公司 |
抑制跨膜絲胺酸蛋白酶6(tmprss6)表現的組成物及方法
|
WO2024031101A1
(en)
|
2022-08-05 |
2024-02-08 |
Sanegene Bio Usa Inc. |
Double stranded rna targeting angiotensinogen (agt) and methods of use thereof
|
WO2024040041A1
(en)
|
2022-08-15 |
2024-02-22 |
Dicerna Pharmaceuticals, Inc. |
Regulation of activity of rnai molecules
|
WO2024079076A1
(en)
|
2022-10-11 |
2024-04-18 |
Boehringer Ingelheim International Gmbh |
Methods for the treatment of nash with advanced fibrosis and/or cirrhosis
|
US20240139230A1
(en)
|
2022-10-11 |
2024-05-02 |
Boehringer Ingelheim International Gmbh |
Dosage regimen for the treatment of nash
|
US20240175026A1
(en)
|
2022-10-14 |
2024-05-30 |
Sanegene Bio Usa Inc. |
Small interfering rna targeting c3 and uses thereof
|
WO2024107993A1
(en)
|
2022-11-16 |
2024-05-23 |
Dicerna Pharmaceuticals, Inc. |
Stat3 targeting oligonucleotides and uses thereof
|