DE69125374T2 - Endonukleasen - Google Patents

Endonukleasen

Info

Publication number
DE69125374T2
DE69125374T2 DE69125374T DE69125374T DE69125374T2 DE 69125374 T2 DE69125374 T2 DE 69125374T2 DE 69125374 T DE69125374 T DE 69125374T DE 69125374 T DE69125374 T DE 69125374T DE 69125374 T2 DE69125374 T2 DE 69125374T2
Authority
DE
Germany
Prior art keywords
deoxyribonucleotides
cleavage
derivatives
endonuclease
rna transcripts
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69125374T
Other languages
English (en)
Other versions
DE69125374D1 (en
Inventor
Philip Jennings
Call Maxine Mc
Philip Hendry
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Gene Shears Pty Ltd
Original Assignee
Gene Shears Pty Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Gene Shears Pty Ltd filed Critical Gene Shears Pty Ltd
Application granted granted Critical
Publication of DE69125374D1 publication Critical patent/DE69125374D1/de
Publication of DE69125374T2 publication Critical patent/DE69125374T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/16—Hydrolases (3) acting on ester bonds (3.1)
    • C12N9/22—Ribonucleases RNAses, DNAses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/10—Type of nucleic acid
    • C12N2310/11—Antisense
    • C12N2310/111—Antisense spanning the whole gene, or a large part of it
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/10—Type of nucleic acid
    • C12N2310/12—Type of nucleic acid catalytic nucleic acids, e.g. ribozymes
    • C12N2310/121—Hammerhead
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/32—Chemical structure of the sugar
    • C12N2310/322—2'-R Modification
DE69125374T 1990-06-19 1991-06-17 Endonukleasen Expired - Fee Related DE69125374T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
AUPK067990 1990-06-19
AUPK400290 1990-12-21
PCT/AU1991/000256 WO1991019789A1 (en) 1990-06-19 1991-06-17 Endonucleases

Publications (2)

Publication Number Publication Date
DE69125374D1 DE69125374D1 (en) 1997-04-30
DE69125374T2 true DE69125374T2 (de) 1997-10-23

Family

ID=25643889

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69125374T Expired - Fee Related DE69125374T2 (de) 1990-06-19 1991-06-17 Endonukleasen

Country Status (11)

Country Link
US (3) US5298612A (de)
EP (1) EP0535067B1 (de)
JP (1) JPH05509224A (de)
KR (1) KR930701590A (de)
AT (1) ATE150789T1 (de)
CA (1) CA2084790C (de)
DE (1) DE69125374T2 (de)
FI (1) FI925715A0 (de)
IL (1) IL98543A (de)
NZ (1) NZ238614A (de)
WO (1) WO1991019789A1 (de)

Families Citing this family (32)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6365730B1 (en) * 1990-06-19 2002-04-02 Gene Shears Pty. Limited DNA-Armed ribozymes and minizymes
JP3257675B2 (ja) * 1990-10-12 2002-02-18 マックス−プランク−ゲゼルシャフト ツール フェルデルング デル ビッセンシャフテン エー．ファウ． 修飾リボザイム
US6041910A (en) * 1997-09-22 2000-03-28 Jervis B. Webb Company Baggage pusher device and system
US5652094A (en) * 1992-01-31 1997-07-29 University Of Montreal Nucleozymes
US5484589A (en) * 1992-04-20 1996-01-16 Rufeld, Inc. Anti-viral methods using RNAse and DNAse
US5610054A (en) * 1992-05-14 1997-03-11 Ribozyme Pharmaceuticals, Inc. Enzymatic RNA molecule targeted against Hepatitis C virus
US5599704A (en) * 1992-08-26 1997-02-04 Ribozyme Pharmaceuticals, Inc. ErbB2/neu targeted ribozymes
US5891684A (en) * 1992-10-15 1999-04-06 Ribozyme Pharmaceuticals, Inc. Base-modified enzymatic nucleic acid
ATE269405T1 (de) * 1992-11-03 2004-07-15 Gene Shears Pty Ltd Tnf-alpha ribozyme und abbau-resistente mrna derivative gebunden an tnf-alpha ribozyme
GB9225427D0 (en) * 1992-12-04 1993-01-27 Ribonetics Gmbh Oligonucleotides with rna cleavage activity
US5817635A (en) * 1993-08-09 1998-10-06 Max-Planck-Gesellschaft Zur Forderung Der Wissenschaften E.V. Modified ribozymes
ATE227342T1 (de) * 1993-09-02 2002-11-15 Ribozyme Pharm Inc Enzymatische nukleiksaüre die nicht-nukleotide enthaltet
WO1995010608A1 (en) * 1993-10-15 1995-04-20 Foundation For Research And Technology - Hellas (Fo.R.T.H.) Asymmetric hammerhead ribozymes and nucleotide sequences for their construction
US5861288A (en) * 1993-10-18 1999-01-19 Ribozyme Pharmaceuticals, Inc. Catalytic DNA
CA2176035A1 (en) 1993-11-08 1995-05-18 Nassim Usman Base-modified enzymatic nucleic acid
AU2099095A (en) * 1994-03-07 1995-09-25 Immusol, Inc Ribozyme therapy for restenosis
WO1995024477A1 (en) * 1994-03-08 1995-09-14 City Of Hope Human papillomavirus targeted ribozymes
US5998193A (en) * 1994-06-24 1999-12-07 Gene Shears Pty., Ltd. Ribozymes with optimized hybridizing arms, stems, and loops, tRNA embedded ribozymes and compositions thereof
US5672501A (en) * 1994-12-23 1997-09-30 Ribozyme Pharmaceuticals, Inc. Base-modified enzymatic nucleic acid
US5663064A (en) * 1995-01-13 1997-09-02 University Of Vermont Ribozymes with RNA protein binding site
US5872241A (en) * 1995-01-25 1999-02-16 The Trustees Of Columbia University In The City Of New York Multiple component RNA catalysts and uses thereof
EP0837933A4 (de) * 1995-06-07 2003-05-21 Commw Scient Ind Res Org Optimierte minizyme und miniribozyme und deren anwendungen
US6004806A (en) * 1995-06-07 1999-12-21 Commonwealth Scientific And Industrial Research Organization Optimized minizymes and miniribozymes and uses thereof
ATE213019T1 (de) * 1995-11-14 2002-02-15 Vimrx Holdings Ltd Chimäre oligomere mit einer rns- spaltungsaktivität
US5728818A (en) * 1996-01-16 1998-03-17 Ribozyme Pharmaceuticals, Inc. Chemical linkage of ribozyme protions
JP2000509969A (ja) * 1996-04-02 2000-08-08 コモンウェルス・サイエンティフィック・アンド・インダストリアル・リサーチ・オーガニゼーション 非対称ハンマーヘッド型リボザイム
WO1999016871A2 (en) * 1997-09-22 1999-04-08 Max-Planck-Gesellschaft Zur Forderung Der Wissensc Nucleic acid catalysts with endonuclease activity
US6326193B1 (en) * 1999-11-05 2001-12-04 Cambria Biosciences, Llc Insect control agent
CA2412026A1 (en) * 2000-06-07 2001-12-13 Biosynexus Incorporated Immunostimulatory rna/dna hybrid molecules
AU2002359761A1 (en) 2001-12-18 2003-06-30 Invenux, Inc. Antibiotic compounds
AU2003296945A1 (en) * 2002-12-12 2004-07-09 Chiron Corporation Device and method for in-line blood testing using biochips
WO2018035423A1 (en) * 2016-08-19 2018-02-22 Bluebird Bio, Inc. Genome editing enhancers

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4511713A (en) * 1980-11-12 1985-04-16 The Johns Hopkins University Process for selectively controlling unwanted expression or function of foreign nucleic acids in animal or mammalian cells
US5023243A (en) * 1981-10-23 1991-06-11 Molecular Biosystems, Inc. Oligonucleotide therapeutic agent and method of making same
US4987071A (en) * 1986-12-03 1991-01-22 University Patents, Inc. RNA ribozyme polymerases, dephosphorylases, restriction endoribonucleases and methods
WO1989005852A1 (en) * 1987-12-15 1989-06-29 Macphillamy Cummins & Gibson Ribozymes
DK0387775T3 (da) * 1989-03-16 1996-11-04 Boehringer Ingelheim Int Genetisk enhed til inhibering af funktionen af RNA
US5149796A (en) * 1989-08-31 1992-09-22 City Of Hope Chimeric DNA-RNA catalytic sequences
DE3929741A1 (de) * 1989-09-07 1991-03-28 Hoechst Ag Rna mit endoribonucleaseaktivitaet gegen mrna von reifungsgenen, ihre herstellung und ihre verwendung in pflanzen

Also Published As

Publication number Publication date
US6001989A (en) 1999-12-14
FI925715A (fi) 1992-12-16
US5972701A (en) 1999-10-26
NZ238614A (en) 1993-07-27
EP0535067A4 (en) 1993-07-28
DE69125374D1 (en) 1997-04-30
US5298612A (en) 1994-03-29
CA2084790C (en) 2002-04-09
WO1991019789A1 (en) 1991-12-26
IL98543A0 (en) 1992-07-15
CA2084790A1 (en) 1991-12-20
EP0535067B1 (de) 1997-03-26
JPH05509224A (ja) 1993-12-22
FI925715A0 (fi) 1992-12-16
IL98543A (en) 2000-02-17
EP0535067A1 (de) 1993-04-07
ATE150789T1 (de) 1997-04-15
KR930701590A (ko) 1993-06-12

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Legal Events

Date Code Title Description
8327 Change in the person/name/address of the patent owner

Owner name: GENE SHEARS PTY LTD., NORTH RYDE, NEUSUEDWALES, AU

8328 Change in the person/name/address of the agent

Free format text: DERZEIT KEIN VERTRETER BESTELLT

8364 No opposition during term of opposition
8327 Change in the person/name/address of the patent owner

Owner name: GENE SHEARS PTY. LTD., CANBERRA, AU

8339 Ceased/non-payment of the annual fee