BR0107536A - Rna isolado, extrato solúvel, método para produzir rna de cerca de 21 a cerca de 23 nucleotìdeos de comprimento; dna isolado - Google Patents

Rna isolado, extrato solúvel, método para produzir rna de cerca de 21 a cerca de 23 nucleotìdeos de comprimento; dna isolado

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Publication number
BR0107536A
BR0107536A BR0107536A BR0107536A BR0107536A BR 0107536 A BR0107536 A BR 0107536A BR 0107536 A BR0107536 A BR 0107536A BR 0107536 A BR0107536 A BR 0107536A BR 0107536 A BR0107536 A BR 0107536A
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Brazil
Prior art keywords
fragments
rna
length
specific
present
Prior art date
Application number
BR0107536A
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English (en)
Inventor
Thomas Tuschl
Phillip A Sharp
Phillip D Zamore
David P Bartel
Original Assignee
Whitehead Biomedical Inst
Max Planck Gesellschaft
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=38068195&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=BR0107536(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Whitehead Biomedical Inst, Max Planck Gesellschaft filed Critical Whitehead Biomedical Inst
Priority to BRPI0117340A priority Critical patent/BRPI0117340B1/pt
Priority to BRPI0117341A priority patent/BRPI0117341B1/pt
Priority to BRPI0117339A priority patent/BRPI0117339B1/pt
Priority to BRPI0117338A priority patent/BRPI0117338B1/pt
Publication of BR0107536A publication Critical patent/BR0107536A/pt

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Abstract

"RNA ISOLADO, EXTRATO SOLúVEL, MéTODO PARA PRODUZIR RNA DE CERCA DE 21 A CERCA DE 23 NUCLEOTìDEOS DE COMPRIMENTO; DNA ISOLADO". A presente invenção relaciona-se com um sistema in vitro de Drosophila que foi usado para demonstrar que dsRNA é processado para segmentos de RNA de 21-23 nucleotídeos de comprimento. Além disso, quando estes fragmentos de 21-23 nt são purificados e adicionados de volta aos extratos de Drosophila, eles medeiam interferência de RNA na ausência de dsRNA longo. Portanto, estes fragmentos de 21-23 nt são os mediadores específicos para seq³ência de degradação de RNA. Um sinal molecular, que pode ser seu comprimento específico, deve estar presente nestes fragmentos de 21-23 nt para recrutar fatores celulares envolvidos em RNAi. Esta presente invenção abrange estes fragmentos de 21-23 nt e seu uso para inativar especificamente função de gene. O uso destes fragmentos (ou oligonucleotídeos sintetizados quimicamente de natureza igual ou similar) habilita o alvejamento de mRNAs específicos para degradação em células de mamíferos, onde o uso de dsRNAs longos para produzir função de gene é útil em aplicações genómicas e terapêuticas funcionais.
BR0107536A 2000-03-30 2001-03-30 Rna isolado, extrato solúvel, método para produzir rna de cerca de 21 a cerca de 23 nucleotìdeos de comprimento; dna isolado BR0107536A (pt)

Priority Applications (4)

Application Number Priority Date Filing Date Title
BRPI0117340A BRPI0117340B1 (pt) 2000-03-30 2001-03-30 método para examinar a função de um gene em uma célula in vitro
BRPI0117341A BRPI0117341B1 (pt) 2000-03-30 2001-03-30 método para avaliar um agente agindo em um produto de gene, método para avaliar se um produto de gene é um alvo adequado para descoberta de drogas e método para avaliar se um produto de gene é um alvo adequado para avaliar a habilidade de um agente agir no produto de gene
BRPI0117339A BRPI0117339B1 (pt) 2000-03-30 2001-03-30 método para identificar sítios alvos dentro de mrna que sejam eficientemente clivados pelo processo rnai, e método para identificar rnas de 21-23 nt que medeiam eficientemente rnai
BRPI0117338A BRPI0117338B1 (pt) 2000-03-30 2001-03-30 método para produzir células animais nocauteadas in vitro e método para produzir uma célula nocauteada

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US19359400P 2000-03-30 2000-03-30
EP00126325 2000-12-01
US26523201P 2001-01-31 2001-01-31
PCT/US2001/010188 WO2001075164A2 (en) 2000-03-30 2001-03-30 Rna sequence-specific mediators of rna interference

Publications (1)

Publication Number Publication Date
BR0107536A true BR0107536A (pt) 2004-03-02

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ID=38068195

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BR0107536A BR0107536A (pt) 2000-03-30 2001-03-30 Rna isolado, extrato solúvel, método para produzir rna de cerca de 21 a cerca de 23 nucleotìdeos de comprimento; dna isolado

Country Status (17)

Country Link
US (19) US20020086356A1 (pt)
EP (3) EP2345742B1 (pt)
JP (6) JP5500750B2 (pt)
KR (3) KR101215789B1 (pt)
AT (1) ATE450621T2 (pt)
AU (4) AU2001249622B2 (pt)
BR (1) BR0107536A (pt)
CA (1) CA2404890C (pt)
CY (2) CY1109864T1 (pt)
DE (1) DE60140676D1 (pt)
DK (2) DK2796553T3 (pt)
ES (2) ES2336887T5 (pt)
HK (5) HK1128733A1 (pt)
IL (4) IL151928A0 (pt)
NZ (2) NZ553687A (pt)
PT (2) PT1309726E (pt)
WO (1) WO2001075164A2 (pt)

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