ES2536438T3 - Métodos y composiciones basados en los microARN para el diagnóstico, pronóstico y tratamiento del cáncer de pulmón - Google Patents
Métodos y composiciones basados en los microARN para el diagnóstico, pronóstico y tratamiento del cáncer de pulmón Download PDFInfo
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Abstract
Un método para determinar el pronóstico de un sujeto con cáncer de pulmón, que comprende la medición del nivel de productos génicos de miR en una muestra de ensayo de dicho sujeto, en el que: la firma de los productos génicos de miR está asociada con un pronóstico adverso en cáncer de pulmón; y una alteración del nivel de los productos génicos de miR en la muestra de ensayo de pulmón, con respecto al nivel de los productos génicos correspondientes de miR en una muestra de control, es indicativa de un pronóstico adverso, en donde el cáncer de pulmón es un adenocarcinoma de pulmón, y los productos génicos de miR consisten en miR-155 y let-7a-2; y en donde el nivel del producto génico de miR-155 en la muestra de ensayo es mayor que el nivel del producto génico correspondiente de miR en la muestra de control, y en donde el nivel del producto génico de let-7a-2 en la muestra de ensayo es menor que el nivel del producto génico correspondiente de miR en la muestra de control.
Description
E12165748
07-05-2015
Las Tablas 1a y 1b describen las secuencias de nucleótidos de microARN humanos precursores y maduros. Tabla 1a-Secuencias de precursores de microARN humano
- Nombre del Precursor
- Secuencia (de 5’ a 3’)* SEC ID Nº
- let-7A-1
- 1
- let-7a-2
- 2
- let-7a-3
- 3
- let-7a-4
-
imagen6 4
- let-7b
-
imagen7 5
- let-7c
- 6
- let-7d
- 7
- let-7d-v1
- 8
- let-7d-v2
- 9
- let-7e
- 10
- let-7f-1
- 11
- let-7f-2-1
- 12
- let-7f-2-2
- 13
- let-7g
- 14
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- let-7i
- 15
- miR-1b-1-1
-
imagen8 16
- miR-1b-1-2
- 17
- miR-1b-2
- 18
- miR-1b
- 19
- miR-1d
-
imagen9 20
- miR-7-1a
- 21
- miR-7-1b
- 22
- miR-7-2
- 23
- miR-7-3
- 24
- miR-9-1
- 25
- miR-9-2
- 26
- miR-9-3
- 27
- miR-10a
- 28
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- miR-10b
- 29
- miR-15a-2
- 30
- miR-15a
- 31
- miR-15b-1
- 32
- miR-15b-2
- 33
- miR-16-1
-
imagen10 34
- miR-16-2
- 35
- miR-16-13
- 36
- miR-17
-
imagen11 37
- miR-18
- 38
- miR-18-13
- 39
- miR-19a
- 40
- miR-19a-13
- 41
- miR-19b-1
-
imagen12 42
- miR-19b-2
- 43
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- miR-19b-13
- 44
- miR-19b-X
-
imagen13 45
- miR-20 (miR-20a)
- 46
- miR-21
- 47
- miR-21-17
-
imagen14 48
- miR-22
- 49
- miR-23a
- 50
- miR-23b
- 51
- miR-23-19
- 52
- miR-24-1
-
imagen15 53
- miR-24-2
-
imagen16 54
- miR-24-19
- 55
- miR-24-9
- 56
- miR-25
- 57
- miR-26a
- 58
- miR-26a-1
-
imagen17 59
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- miR-26a-2
- 60
- miR-26b
-
imagen18 61
- miR-27a
- 62
- miR-27b-1
- 63
- miR-27b-2
-
imagen19 64
- miR-27-19
- 65
- miR-28
-
imagen20 66
- miR-29a-2
- 67
- miR-29a
- 68
- miR-29b-1
- 69
- miR-29b-2
- 70
- miR-29c
- 71
- miR-30a
- 72
- miR-30b-1
- 73
- miR-30b-2
- 74
- miR-30c
- 75
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- miR-30d
- 76
- miR-30e
- 77
- miR-31
-
imagen21 78
- miR-32
- 79
- miR-33b
- 80
- miR-33b-2
- 81
- miR-33
- 82
- miR-34-a
- 83
- miR-34-b
- 84
- miR-34-c
- 85
- miR-91-13
- 86
- miR-92-1
- 87
- miR-92 -2
-
imagen22 88
- miR-93-1 (miR93-2)
- 89
- miR-95-4
- 90
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- miR-96-7
- 91
- miR-97-6 (miR30*)
- 92
- miR-98
- 93
- miR-99b
-
imagen23 94
- miR-99a
- 95
- miR-100-1/2
- 96
- miR-100-11
- 97
- miR-101-1/2
- 98
- miR-101
- 99
- miR-101-1
- 100
- miR-101-2
- 101
- miR-101-9
- 102
- miR-102-1
- 103
- miR-102-7.1 (miR-102-7.2)
- 104
- miR-103-2
- 105
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- miR-103-1
- 106
- miR-104-17
- 107
- miR-105-1
-
imagen24 108
- miR-105-2
- 109
- miR-106-a
- 110
- miR-106-b
- 111
- miR-107
-
imagen25 112
- miR-108-1pequeño
- 113
- miR-108-2pequeño
-
imagen26 114
- miR-122a-1
- 115
- miR-122a-2
- 116
- miR-123
-
imagen27 117
- miR-124a-1
- 118
- miR-124a-2
- 119
- miR-124a-3
- 120
- miR-124a
- 121
- miR-124b
- 122
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- miR-125a-1
- 123
- miR-125a-2
- 124
- miR-125b-1
-
imagen28 125
- miR-125b-2
- 126
- miR-126-1
- 127
- miR-126-2
-
imagen29 128
- miR-127-1
- 129
- miR-127-2
- 130
- miR-128a
- 131
- miR-128b
- 132
- miR-128
- 133
- miR-129-1
- 134
- miR-129-2
- 135
- miR-130a
- 136
- miR-131-1
- 137
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- miR-131-3
- 138
- miR-131
- 139
- miR-132-1
- 140
- miR-132-2
-
imagen30 141
- miR-133a-1
-
imagen31 142
- miR-133a-2
- 143
- miR-133
- 144
- miR-133b
- 145
- miR-133bpequeño
- 146
- miR-134-1
- 147
- miR-134-2
- 148
- miR-135a-1
- 149
- miR-135a-2 (miR135-2)
- 150
- miR-135
-
imagen32 151
- miR-135b
- 152
- miR-136-1
-
imagen33 153
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- miR-136-2
- 154
- miR-137
- 155
- miR-138-1
-
imagen34 156
- miR-138-2
-
imagen35 157
- miR-138
- 158
- miR-139
- 159
- miR-140
- 160
- miR-140as
-
imagen36 161
- miR-140s
- 162
- miR-141-1
- 163
- miR-141-2
-
imagen37 164
- miR-142
-
imagen38 165
- miR-143-1
- 166
- miR-143-2
- 167
- miR-144-1
- 168
- miR-144-2
- 169
- miR-145-1
- 170
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- miR-1 45-2
- 171
- miR-146-1
- 172
- miR-146-2
-
imagen39 173
- miR-147
- 174
- miR-148a (miR148)
- 175
- miR-148b
-
imagen40 176
- miR-148bpequeño
- 177
- miR-149-1
- 178
- miR-149-2
- 179
- miR-150-1
- 180
- miR-150-2
- 181
- miR-151
-
imagen41 182
- miR-151-2
- 183
- miR-152-1
- 184
- miR-152-2
- 185
- miR-153-1-1
- 186
- miR-153-1-2
-
imagen42 187
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- miR-153-2-1
- 188
- miR-153-2-2
- 189
- miR-154-1
-
imagen43 190
- miR-154-2
-
imagen44 191
- miR-155
-
imagen45 192
- miR-156 = miR157=solapamiento miR-141
-
imagen46 193
- miR-158pequeño = miR192
-
imagen47 194
- miR-159-1pequeño
-
imagen48 195
- miR-161pequeño
-
imagen49 196
- miR-163-1bpequeño
- 197
- miR-163-3pequeño
- 198
- miR-162
- 199
- miR-175pequeño =miR224
- 200
- miR-177pequeño
- 201
- miR-180pequeño
- 202
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- miR-181a
- 203
- miR-181b-1
- 204
- miR-181b-2
-
imagen50 205
- miR-181c
- 206
- miR-182-as
-
imagen51 207
- miR-182
- 208
- miR-183
- 209
- miR-184-1
- 210
- miR-184-2
-
imagen52 211
- miR-185-1
- 212
- miR-185-2
- 213
- miR-186-1
- 214
- miR-186-2
- 215
- miR-187
- 216
- miR-188-1
- 217
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- miR-188-2
- 218
- miR-189-1
- 219
- miR-189-2
-
imagen53 220
- miR-190-1
- 221
- miR-190-2
-
imagen54 222
- miR-191-1
- 223
- miR-191-2
- 224
- miR-192-2/3
- 225
- miR-192
- 226
- miR-193-1
- 227
- miR-193-2
- 228
- miR-194-1
-
imagen55 229
- miR-194-2
- 230
- miR-195-1
-
imagen56 231
- miR-195-2
- 232
- miR-196-1
- 233
- miR-196a-1
- 234
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- miR-196a-2 (miR196-2)
- 235
- miR-196
-
imagen57 236
- miR-196b
- 237
- miR-197
- 238
- miR-197-2
- 239
- miR-198
- 240
- miR-199a-1
- 241
- miR-199a-2
- 242
- miR-199b
- 243
- miR-199s
- 244
- miR-200a
- 245
- miR-200b
- 246
- miR-200c
-
imagen58 247
- miR-202
- 248
- miR-203
-
imagen59 249
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- miR-204
- 250
- miR-205
- 251
- miR-206-1
- 252
- miR-206-2
- 253
- miR-208
- 254
- miR-210
- 255
- miR-211
- 256
- miR-212
-
imagen60 257
- miR-213-2
- 258
- miR-213
- 259
- miR-95-4
- 260
- miR-215
- 261
- miR-216
- 262
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- miR-217
- 263
- miR-218-1
-
imagen61 264
- miR-218-2
- 265
- miR-219
- 266
- miR-219-1
- 267
- miR-219-2
- 268
- miR-220
- 269
- miR-221
- 270
- miR-222
- 271
- miR-223
- 272
- miR-95-4
-
imagen62 273
- miR-294-1 (chr16)
- 274
- miR-296
- 275
- miR-299
- 276
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- miR-301
- 277
- miR-302a
- 278
- miR-302b
-
imagen63 279
- miR-302c
- 280
- miR-302d
- 281
- miR-320
-
imagen64 282
- miR-321
- 283
- miR-323
-
imagen65 284
- miR-324
-
imagen66 285
- miR-325
- 286
- miR-326
- 287
- miR-328
- 288
- miR-330
- 289
- miR-331
- 290
- miR-335
- 291
- miR-337
- 292
- miR-338
- 293
- miR-339
- 294
07-05-2015
- miR-340
- 295
- miR-342
- 296
- miR-345
- 297
- miR-346
- 298
- miR-367
-
imagen67 299
- miR-368
- 300
- miR-369
- 301
- miR-370
- 302
- miR-371
- 303
- miR-372
- 304
- miR-373
- 305
- miR-374
- 306
- miR-hes1
- 307
- miR-hes2
- 308
- miR-hes3
- 309
- * Una secuencia subrayada dentro de una secuencia de precursor corresponde a un transcrito de miR procesado maduro (véase la Tabla 1b). Algunas secuencias de precursor tienen dos secuencias subrayadas que indican dos miR maduros diferentes que se obtienen a partir del mismo precursor. Todas las secuencias son humanas.
Tabla 1b -Secuencias de microRNA Maduro Humano.
- Nombre de miRNA Maduro
- Secuencia de miRNA Maduro (5’ a 3’) SEC ID Nº microRNA precursor correspondiente(s); véase la Tabla 1a
- let-7a
- ugagguaguagguuguauaguu 310 let-7a-1; let-7a-2; let-7a-3; let-7a-4
- let-7b
- ugagguaguagguugugugguu 311
- let-7b
- let-7c
- ugagguaguagguuguaugguu 312
- let-7c
- let-7d
- agagguaguagguugcauagu 313 let-7d; let-7d-v1
- let-7e
- ugagguaggagguuguauagu 314
- let-7e
- let-7f
- ugagguaguagauuguauaguu 315 let-7f-1; let-7f-2-1; let-7f-2-2
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- let-7g
- ugagguaguaguuuguacagu 316
- let-7g
- let-7i
- ugagguaguaguuugugcu 317
- let-7i
- miR-1
- uggaauguaaagaaguaugua 318 miR-1b; miR-1b-1; miR-1b-2
- miR-7
- uggaagacuagugauuuuguu 319 miR-7-1; miR-7-1a; miR-7-2; miR-7-3
- miR-9
- ucuuugguuaucuagcuguauga 320 miR-9-1; miR-9-2; miR-9-3
- miR-9*
- uaaagcuagauaaccgaaagu 321 miR-9-1; miR-9-2; miR-9-3
- miR-10a
- uacccuguagauccgaauuugug 322
- miR-10a
- miR-10b
- uacccuguagaaccgaauuugu 323
- miR-10b
- miR-15a
- uagcagcacauaaugguuugug 324 miR-15a; miR-15a-2
- miR-15b
- uagcagcacaucaugguuuaca 325
- miR-15b
- miR-16
- uagcagcacguaaauauuggcg 326 miR-16-1; miR-16-2; miR-16-13
- miR-17-5p
- caaagugcuuacagugcagguagu 327 miR-17
- miR-17-3p
- acugcagugaaggcacuugu 328 miR-17
- miR-18
- uaaggugcaucuagugcagaua 329 miR-18; miR-18-13
- miR-19a
- ugugcaaaucuaugcaaaacuga 330 miR-19a; miR-19a-13
- miR-19b
- ugugcaaauccaugcaaaacuga 331 miR-19b-1; miR-19b-2
- miR-20
- uaaagugcuuauagugcaggua 332 miR-20 (miR-20a)
- miR-21
- uagcuuaucagacugauguuga 333 miR-21; miR-21-17
- miR-22
- aagcugccaguugaagaacugu 334
- miR-22
- miR-23a
- aucacauugccagggauuucc 335
- miR-23a
- miR-23b
- aucacauugccagggauuaccac 336
- miR-23b
- miR-95-4
- uggcucaguucagcaggaacag 337 miR-24-1; miR-24-2; miR-24-19; miR24-9
- miR-25
- cauugcacuugucucggucuga 338
- miR-25
- miR-26a
- uucaaguaauccaggauaggcu 339 miR-26a; miR-26a-1; miR-26a-2
- miR-26b
- uucaaguaauucaggauaggu 340
- miR-26b
- miR-27a
- uucacaguggcuaaguuccgcc 341
- miR-27a
- miR-27b
- uucacaguggcuaaguucug 342 miR-27b-1; miR-27b-2
- miR-28
- aaggagcucacagucuauugag 343
- miR-28
- miR-29a
- cuagcaccaucugaaaucgguu 344 miR-29a-2; miR-29a
- miR-29b
- uagcaccauuugaaaucagu 345 miR-29b-1; miR-29b-2
- miR-29c
- uagcaccauuugaaaucgguua 346
- miR-29c
- miR-30a-5p
- uguaaacauccucgacuggaagc 347 miR-30a
- miR-30a-3p
- cuuucagucggauguuugcagc 348 miR-30a
- miR-30b
- uguaaacauccuacacucagc 349 miR-30b-1; miR-30b-2
- miR-30c
- uguaaacauccuacacucucagc 350
- miR-30c
- miR-30d
- uguaaacauccccgacuggaag 351
- miR-30d
- miR-30e
- uguaaacauccuugacugga 352
- miR-30e
- miR-31
- ggcaagaugcuggcauagcug 353
- miR-31
- miR-32
- uauugcacauuacuaaguugc 354
- miR-32
- miR-33
- gugcauuguaguugcauug 355 miR-33; miR-33b
- miR-34a
- uggcagugucuuagcugguugu 356
- miR-34a
- miR-34b
- aggcagugucauuagcugauug 357
- miR-34b
- miR-34c
- aggcaguguaguuagcugauug 358
- miR-34c
- miR-92
- uauugcacuugucccggccugu 359 miR-92-2; miR-92-1
- miR-93
- aaagugcuguucgugcagguag 360 miR-93-1; miR-93-2
- miR-95
- uucaacggguauuuauugagca 361
- miR-95
- miR-96
- uuuggcacuagcacauuuuugc 362
- miR-96
- miR-98
- ugagguaguaaguuguauuguu 363
- miR-98
- miR-99a
- aacccguagauccgaucuugug 364
- miR-99a
- miR-99b
- cacccguagaaccgaccuugcg 365
- miR-99b
- miR-100
- uacaguacugugauaacugaag 366
- miR-100
- miR-101
- uacaguacugugauaacugaag 367 miR-101-1; miR-101-2
- miR-103
- agcagcauuguacagggcuauga 368 miR-103-1
- miR-105
- ucaaaugcucagacuccugu 369
- miR-105
- miR-106-a
- aaaagugcuuacagugcagguagc 370
- miR-106-a
- miR-106-b
- uaaagugcugacagugcagau 371
- miR-106-b
- miR-107
- agcagcauuguacagggcuauca 372
- miR-107
- miR-122a
- uggagugugacaaugguguuugu 373 miR-122a-1; miR-122a-2
- miR-124a
- uuaaggcacgcggugaaugcca 374 miR-124a-1; miR-124a-2; miR-124a-3
- miR-125a
- ucccugagacccuuuaaccugug 375 miR-125a-1; miR-125a-2
07-05-2015 E12165748
- miR-125b
- ucccugagacccuaacuuguga 376 miR-125b-1; miR-125b-2
- miR-126*
- cauuauuacuuuugguacgcg 377 miR-126-1; miR-126-2
- miR-126
- ucguaccgugaguaauaaugc 378 miR-126-1; miR-126-2
- miR-127
- ucggauccgucugagcuuggcu 379 miR-127-1; miR-127-2
- miR-128a
- ucacagugaaccggucucuuuu 380 miR-128; miR-128a
- miR-128b
- ucacagugaaccggucucuuuc 381
- miR-128b
- miR-129
- cuuuuugcggucugggcuugc 382 miR-129-1; miR-129-2
- miR-130a
- cagugcaauguuaaaagggc 383
- miR-130a
- miR-130b
- cagugcaaugaugaaagggcau 384
- miR-130b
- miR-132
- uaacagucuacagccauggucg 385 miR-132-1
- miR-133a
- uugguccccuucaaccagcugu 386 miR-133a-1; miR-133a-2
- miR-133b
- uugguccccuucaaccagcua 387
- miR-133b
- miR-95-4
- ugugacugguugaccagaggg 388 miR-134-1; miR-134-2
- miR-135a
- uauggcuuuuuauuccuauguga 389 miR-135a; miR-135a-2 (miR-135-2)
- miR-135b
- uauggcuuuucauuccuaugug 390
- miR-135b
- miR-136
- acuccauuuguuuugaugaugga 391 miR-136-1; miR-136-2
- miR-137
- uauugcuuaagaauacgcguag 392
- miR-137
- miR-138
- agcugguguugugaauc 393 miR-138-1; miR-138-2
- miR-139
- ucuacagugcacgugucu 394
- miR-139
- miR-140
- agugguuuuacccuaugguag 395 miR-140; miR-140as; miR-140s
- miR-141
- aacacugucugguaaagaugg 396 miR-141-1; miR-141-2
- miR-142-3p
- uguaguguuuccuacuuuaugga 397 miR-142
- miR-142-5p
- cauaaaguagaaagcacuac 398 miR-142
- miR-143
- ugagaugaagcacuguagcuca 399 miR-143-1
- miR-144
- uacaguauagaugauguacuag 400 miR-144-1; miR-144-2
- miR-145
- guccaguuuucccaggaaucccuu 401 miR-145-1; miR-145-2
- miR-146
- ugagaacugaauuccauggguu 402 miR-146-1; miR-146-2
- miR-147
- guguguggaaaugcuucugc 403
- miR-147
- miR-148a
- ucagugcacuacagaacuuugu 404 miR-148a (miR-148)
- miR-148b
- ucagugcaucacagaacuuugu 405
- miR-148b
- miR-149
- ucuggcuccgugucuucacucc 406
- miR-149
- miR-150
- ucucccaacccuuguaccagug 407 miR-150-1; miR-150-2
- miR-151
- acuagacugaagcuccuugagg 408
- miR-151
- miR-152
- ucagugcaugacagaacuugg 409 miR-152-1; miR-152-2
- miR-153
- uugcauagucacaaaaguga 410 miR-153-1-1; miR-153-1-2; miR-1532-1; m iR-153-2-2
- miR-154
- uagguuauccguguugccuucg 411 miR-154-1; miR-154-2
- miR-154*
- aaucauacacgguugaccuauu 412 miR-154-1; miR-154-2
- miR-155
- uuaaugcuaaucgugauagggg 413
- miR-155
- miR-181a
- aacauucaacgcugucggugagu 414
- miR-181a
- miR-181b
- aacauucauugcugucgguggguu 415 miR-181b-1; miR-181b-2
- miR-181c
- aacauucaaccugucggugagu 416
- miR-181c
- miR-182
- uuuggcaaugguagaacucaca 417 miR-182; miR-182as
- miR-182*
- ugguucuagacuugccaacua 418 miR-182; miR-182as
- miR-183
- uauggcacugguagaauucacug 419
- miR-183
- miR-95-4
- uggacggagaacugauaagggu 420 miR-184-1; miR-184-2
- miR-185
- uggagagaaaggcaguuc 421 miR-185-1; miR-185-2
- miR-186
- caaagaauucuccuuuugggcuu 422 miR-186-1; miR-186-2
- miR-187
- ucgugucuuguguugcagccg 423
- miR-187
- miR-188
- caucccuugcaugguggagggu 424
- miR-188
- miR-189
- gugccuacugagcugauaucagu 425 miR-189-1; miR-189-2
- miR-190
- ugauauguuugauauauuaggu 426 miR-190-1; miR-190-2
- miR-191
- caacggaaucccaaaagcagcu 427 miR-191-1; miR-191-2
- miR-192
- cugaccuaugaauugacagcc 428
- miR-192
- miR-193
- aacuggccuacaaagucccag 429 miR-193-1; miR-193-2
- miR-95-4
- uguaacagcaacuccaugugga 430 miR-194-1; miR-194-2
- miR-195
- uagcagcacagaaauauuggc 431 miR-195-1; miR-195-2
- miR-196a
- uagguaguuucauguuguugg 432 miR-196a; miR-196a-2 (miR19
- miR-196b
- uagguaguuuccuguuguugg 433
- miR-196b
- miR-197
- uucaccaccuucuccacccagc 434
- miR-197
- miR-198
- gguccagaggggagauagg 435
- miR-198
07-05-2015
- miR-199a
- cccaguguucagacuaccuguuc 436 miR-199a-1; miR-199a-2
- miR-199a*
- uacaguagucugcacauugguu 437 miR-199a-1; miR-199a-2; miR-199s; miR-199b
- miR-199b
- cccaguguuuagacuaucuguuc 438
- miR-199b
- miR-200a
- uaacacugucugguaacgaugu 439
- miR-200a
- miR-200b
- cucuaauacugccugguaaugaug 440
- miR-200b
- miR-200c
- aauacugccggguaaugaugga 441
- miR-200c
- miR-202
- agagguauagggcaugggaaga 442
- miR-202
- miR-203
- gugaaauguuuaggaccacuag 443
- miR-203
- miR-204
- uucccuuugucauccuaugccu 444
- miR-204
- miR-205
- uccuucauuccaccggagucug 445
- miR-205
- miR-206
- uggaauguaaggaagugugugg 446 miR-206-1; miR-206-2
- miR-208
- auaagacgagcaaaaagcuugu 447
- miR-208
- miR-210
- cugugcgugugacagcggcug 448
- miR-210
- miR-211
- uucccuuugucauccuucgccu 449
- miR-211
- miR-212
- uaacagucuccagucacggcc 450
- miR-212
- miR-213
- accaucgaccguugauuguacc 451
- miR-213
- miR-214
- acagcaggcacagacaggcag 452 miR-95-4
- miR-215
- augaccuaugaauugacagac 453
- miR-215
- miR-216
- uaaucucagcuggcaacugug 454
- miR-216
- miR-217
- uacugcaucaggaacugauuggau 455
- miR-217
- miR-218
- uugugcuugaucuaaccaugu 456 miR-218-1; miR-218-2
- miR-219
- ugauuguccaaacgcaauucu 457 miR-219; miR-219-1; miR-219-2
- miR-220
- ccacaccguaucugacacuuu 458
- miR-220
- miR-221
- agcuacauugucugcuggguuuc 459
- miR-221
- miR-222
- agcuacaucuggcuacugggucuc 460
- miR-222
- miR-223
- ugucaguuugucaaauacccc 461
- miR-223
- miR-224
- caagucacuagugguuccguuua 462
- miR-224
- miR-296
- agggcccccccucaauccugu 463
- miR-296
- miR-299
- ugguuuaccgucccacauacau 464
- miR-299
- miR-301
- cagugcaauaguauugucaaagc 465
- miR-301
- miR-302a
- uaagugcuuccauguuuugguga 466
- miR-302a
- miR-302b*
- acuuuaacauggaagugcuuucu 467 miR-302b
- miR-302b
- uaagugcuuccauguuuuaguag 468
- miR-302b
- miR-302c*
- uuuaacauggggguaccugcug 469 miR-302c
- miR-302c
- uaagugcuuccauguuucagugg 470
- miR-302c
- miR-302d
- uaagugcuuccauguuugagugu 471
- miR-302d
- miR-320
- aaaagcuggguugagagggcgaa 472
- miR-320
- miR-321
- uaagccagggauuguggguuc 473
- miR-321
- miR-323
- gcacauuacacggucgaccucu 474
- miR-323
- miR-324-5p
- cgcauccccuagggcauuggugu 475 miR-324
- miR-324-3p
- ccacugccccaggugcugcugg 476 miR-324
- miR-325
- ccuaguagguguccaguaagu 477
- miR-325
- miR-326
- ccucugggcccuuccuccag 478
- miR-326
- miR-328
- cuggcccucucugcccuuccgu 479
- miR-328
- miR-330
- gcaaagcacacggccugcagaga 480
- miR-330
- miR-331
- gccccugggccuauccuagaa 481
- miR-331
- miR-335
- ucaagagcaauaacgaaaaaugu 482
- miR-335
- miR-337
- uccagcuccuauaugaugccuuu 483
- miR-337
- miR-338
- uccagcaucagugauuuuguuga 484
- miR-338
- miR-339
- ucccuguccuccaggagcuca 485
- miR-339
- miR-340
- uccgucucaguuacuuuauagcc 486
- miR-340
- miR-342
- ucucacacagaaaucgcacccguc 487
- miR-342
- miR-345
- ugcugacuccuaguccagggc 488
- miR-345
- miR-346
- ugucugcccgcaugccugccucu 489
- miR-346
- miR-367
- aauugcacuuuagcaaugguga 490
- miR-367
- miR-368
- acauagaggaaauuccacguuu 491
- miR-368
- miR-369
- aauaauacaugguugaucuuu 492
- miR-369
- miR-370
- gccugcugggguggaaccugg 493
- miR-370
- miR-371
- gugccgccaucuuuugagugu 494
- miR-371
- miR-372
- aaagugcugcgacauuugagcgu 495
- miR-372
Claims (1)
-
imagen1
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US75640006P | 2006-01-05 | 2006-01-05 | |
| US756400P | 2006-01-05 |
Publications (1)
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|---|---|
| ES2536438T3 true ES2536438T3 (es) | 2015-05-25 |
Family
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| ES07717734T Active ES2429404T3 (es) | 2006-01-05 | 2007-01-03 | Procedimientos basados en los microARN para el diagnóstico y el pronóstico del cáncer de pulmón |
| ES12165740.7T Active ES2553442T3 (es) | 2006-01-05 | 2007-01-03 | Procedimientos basados en los microARN para el diagnóstico, pronóstico y tratamiento del cáncer de pulmón |
| ES12165734.0T Active ES2554531T3 (es) | 2006-01-05 | 2007-01-03 | Procedimientos basados en los microARN para el diagnóstico, pronóstico y tratamiento del cáncer de pulmón |
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| ES07717734T Active ES2429404T3 (es) | 2006-01-05 | 2007-01-03 | Procedimientos basados en los microARN para el diagnóstico y el pronóstico del cáncer de pulmón |
| ES12165740.7T Active ES2553442T3 (es) | 2006-01-05 | 2007-01-03 | Procedimientos basados en los microARN para el diagnóstico, pronóstico y tratamiento del cáncer de pulmón |
| ES12165734.0T Active ES2554531T3 (es) | 2006-01-05 | 2007-01-03 | Procedimientos basados en los microARN para el diagnóstico, pronóstico y tratamiento del cáncer de pulmón |
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| AU (1) | AU2007205234B2 (es) |
| CA (1) | CA2633674A1 (es) |
| ES (4) | ES2536438T3 (es) |
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| EP1713938A2 (en) * | 2004-02-09 | 2006-10-25 | Thomas Jefferson University | DIAGNOSIS AND TREATMENT OF CANCERS WITH MicroRNA LOCATED IN OR NEAR CANCER-ASSOCIATED CHROMOSOMAL FEATURES |
| EP2290071B1 (en) | 2004-05-28 | 2014-12-31 | Asuragen, Inc. | Methods and compositions involving microRNA |
| CA2850323A1 (en) | 2004-11-12 | 2006-12-28 | Asuragen, Inc. | Methods and compositions involving mirna and mirna inhibitor molecules |
| EP1937845B1 (en) | 2005-08-01 | 2015-06-10 | The Ohio State University Research Foundation | Micro-rna-based methods and compositions for the diagnosis, prognosis and treatment of breast cancer |
| EP1937280B1 (en) | 2005-09-12 | 2014-08-27 | The Ohio State University Research Foundation | Compositions for the therapy of bcl2-associated cancers |
| EP2487253B1 (en) | 2006-01-05 | 2015-06-24 | The Ohio State University Research Foundation | MicroRNA-based methods and compositions for the diagnosis and treatment of solid cancers |
| US7943318B2 (en) | 2006-01-05 | 2011-05-17 | The Ohio State University Research Foundation | Microrna-based methods and compositions for the diagnosis, prognosis and treatment of lung cancer |
| EP2591794A1 (en) | 2006-01-05 | 2013-05-15 | The Ohio State University Research Foundation | MicroRNA expressions abnormalities in pancreatic endocrine and acinar tumors |
| EP1996731A2 (en) | 2006-03-20 | 2008-12-03 | The Ohio State University Research Foundation | Microrna fingerprints during human megakaryocytopoiesis |
| US8207325B2 (en) * | 2006-04-03 | 2012-06-26 | Univ. of Copenhagen | MicroRNA biomarkers for human breast and lung cancer |
| EP2455494B1 (en) | 2006-07-13 | 2013-12-18 | The Ohio State University Research Foundation | Micro-RNA-based methods and compositions for the diagnosis and treatment of colon related diseases |
| AU2007346101B2 (en) | 2006-09-19 | 2013-08-15 | The Ohio State University Research Foundation | TCL1 expression in chronic lymphocytic leukemia (CLL) regulated by miR-29 and miR-181 |
| EP2487240B1 (en) * | 2006-09-19 | 2016-11-16 | Interpace Diagnostics, LLC | Micrornas differentially expressed in pancreatic diseases and uses thereof |
| EP2087135B8 (en) | 2006-11-01 | 2013-07-24 | The Ohio State University Research Foundation | Microrna expression signature for predicting survival and metastases in hepatocellular carcinoma |
| WO2008058018A2 (en) | 2006-11-02 | 2008-05-15 | Mayo Foundation For Medical Education And Research | Predicting cancer outcome |
| CN103555825B (zh) | 2007-01-31 | 2015-09-30 | 俄亥俄州立大学研究基金会 | 用于急性髓细胞白血病(aml)的诊断、预后和治疗的基于微rna的方法和组合物 |
| AU2008248319B2 (en) * | 2007-04-30 | 2013-09-05 | The Ohio State University Research Foundation | Methods for differentiating pancreatic cancer from normal pancreatic function and/or chronic pancreatitis |
| JP5690588B2 (ja) | 2007-06-08 | 2015-03-25 | アメリカ合衆国 | 肝細胞癌のサブタイプを決定し、肝癌幹細胞を検出するための方法 |
| CN101918424A (zh) | 2007-06-15 | 2010-12-15 | 俄亥俄州立大学研究基金会 | 用于靶向由Drosha介导的微小RNA加工的致癌ALL-1融合蛋白 |
| EP2808398A1 (en) * | 2007-07-31 | 2014-12-03 | The Ohio State University Research Foundation | Methods for reverting methylation by targeting DNMT3A and DNMT3B |
| AU2008283795B2 (en) | 2007-07-31 | 2013-11-21 | Board Of Regents, The University Of Texas System | A micro-RNA family that modulates fibrosis and uses thereof |
| ES2627059T3 (es) | 2007-08-03 | 2017-07-26 | The Ohio State University Research Foundation | Regiones ultraconservadas que codifican ARNnc |
| EP2188395A4 (en) * | 2007-08-17 | 2010-10-13 | Catalyst Assets Llc | USE OF MICRO-RNA ASSOCIATED WITH CANCER OF THE HUMAN BLADDER FOR DIAGNOSIS AND PROGNOSIS |
| CA2696887C (en) | 2007-08-22 | 2016-06-28 | The Ohio State University Research Foundation | Methods and compositions for inducing deregulation of epha7 and erk phosphorylation in human acute leukemias |
| WO2009024790A1 (en) * | 2007-08-23 | 2009-02-26 | Isis Innovation Limited | Method and kit for the prognosis of cancer by determining the level of mirna-210 |
| US8361714B2 (en) | 2007-09-14 | 2013-01-29 | Asuragen, Inc. | Micrornas differentially expressed in cervical cancer and uses thereof |
| JPWO2009044899A1 (ja) * | 2007-10-03 | 2011-02-17 | 協和発酵キリン株式会社 | 細胞の増殖を制御する核酸 |
| JP5723156B2 (ja) * | 2007-10-11 | 2015-05-27 | ジ・オハイオ・ステイト・ユニバーシティ・リサーチ・ファウンデイションＴｈｅ Ｏｈｉｏ Ｓｔａｔｅ Ｕｎｉｖｅｒｓｉｔｙ Ｒｅｓｅａｒｃｈ Ｆｏｕｎｄａｔｉｏｎ | 食道腺癌の診断及び治療のための方法及び組成物 |
| US20090186015A1 (en) * | 2007-10-18 | 2009-07-23 | Latham Gary J | Micrornas differentially expressed in lung diseases and uses thereof |
| JP2011504093A (ja) | 2007-10-26 | 2011-02-03 | ジ・オハイオ・ステイト・ユニバーシティ・リサーチ・ファウンデイション | 脆弱性ヒスチジン三連構造（ｆｈｉｔ）相互作用を同定するための方法およびその使用 |
| EP2215263A1 (en) | 2007-10-30 | 2010-08-11 | Veridex LLC | Process for predicting the prognosis of squamous cell lung cancer |
| US20100323357A1 (en) * | 2007-11-30 | 2010-12-23 | The Ohio State University Research Foundation | MicroRNA Expression Profiling and Targeting in Peripheral Blood in Lung Cancer |
| WO2009070805A2 (en) | 2007-12-01 | 2009-06-04 | Asuragen, Inc. | Mir-124 regulated genes and pathways as targets for therapeutic intervention |
| JP5116026B2 (ja) * | 2008-01-23 | 2013-01-09 | 富士フイルム株式会社 | 癌の検出方法および癌抑制剤 |
| EP2247750A4 (en) * | 2008-02-01 | 2011-10-26 | Univ Leland Stanford Junior | METHODS AND COMPOSITIONS RELATING TO CANCER STEM CELLS |
| JP5662166B2 (ja) * | 2008-02-28 | 2015-01-28 | ジ・オハイオ・ステイト・ユニバーシティ・リサーチ・ファウンデイションＴｈｅ Ｏｈｉｏ Ｓｔａｔｅ Ｕｎｉｖｅｒｓｉｔｙ Ｒｅｓｅａｒｃｈ Ｆｏｕｎｄａｔｉｏｎ | 胃癌の診断、予後診断及び治療のためのマイクロｒｎａに基づいた方法及び組成物 |
| EP2285960B1 (en) | 2008-05-08 | 2015-07-08 | Asuragen, INC. | Compositions and methods related to mir-184 modulation of neovascularization or angiogenesis |
| CA2725978A1 (en) | 2008-05-28 | 2009-12-03 | Genomedx Biosciences, Inc. | Systems and methods for expression-based discrimination of distinct clinical disease states in prostate cancer |
| US10407731B2 (en) | 2008-05-30 | 2019-09-10 | Mayo Foundation For Medical Education And Research | Biomarker panels for predicting prostate cancer outcomes |
| EP2294218A2 (en) * | 2008-06-02 | 2011-03-16 | New York University | Compositions and methods for diagnosis, prognosis and treatment of mesothelioma |
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