BR112019008810A2 - micrornas modificadas com 5-halouracila e seu uso no tratamento de câncer - Google Patents

micrornas modificadas com 5-halouracila e seu uso no tratamento de câncer

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Publication number
BR112019008810A2
BR112019008810A2 BR112019008810A BR112019008810A BR112019008810A2 BR 112019008810 A2 BR112019008810 A2 BR 112019008810A2 BR 112019008810 A BR112019008810 A BR 112019008810A BR 112019008810 A BR112019008810 A BR 112019008810A BR 112019008810 A2 BR112019008810 A2 BR 112019008810A2
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Brazil
Prior art keywords
halouracil
nucleic acid
cancer
present
microrna
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BR112019008810A
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English (en)
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Ju Jingfang
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Univ New York State Res Found
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Publication of BR112019008810A2 publication Critical patent/BR112019008810A2/pt

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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C12N15/1135—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against oncogenes or tumor suppressor genes
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    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A61K31/7115—Nucleic acids or oligonucleotides having modified bases, i.e. other than adenine, guanine, cytosine, uracil or thymine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A61K31/712—Nucleic acids or oligonucleotides having modified sugars, i.e. other than ribose or 2'-deoxyribose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • C07H21/02—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids with ribosyl as saccharide radical
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    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
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    • C12N2310/00—Structure or type of the nucleic acid
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    • C12N2310/14—Type of nucleic acid interfering N.A.
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    • C12N2310/141—MicroRNAs, miRNAs
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    • C12N2310/00—Structure or type of the nucleic acid
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    • C12N2310/335—Modified T or U
    • C—CHEMISTRY; METALLURGY
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    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/35—Nature of the modification
    • C12N2310/353—Nature of the modification linked to the nucleic acid via an atom other than carbon
    • C12N2310/3533—Halogen

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
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  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

a presente invenção refere-se a composições de ácido nucleico que incorporam uma ou mais moléculas de halouracila. mais especificamente, a presente invenção revela que a substituição de nucleotídeos de uracila em uma sequência nucleotídica de microrna por uma 5-halouracila aumenta a capacidade do microrna de inibir a progressão do câncer e a tumorigênese. como tal, a presente invenção fornece várias composições de ácido nucleico (por exemplo, microrna) tendo moléculas de 5-halouracila incorporadas nas suas sequências de ácido nucleico e métodos para uso das mesmas. a presente descrição fornece ainda composições farmacêuticas (por exemplo, formulações) compreendendo as composições de ácido nucleico modificado, e métodos para o tratamento de câncer, tal como câncer colorretal, câncer de pâncreas e câncer de pulmão.
BR112019008810A 2016-11-01 2017-10-30 micrornas modificadas com 5-halouracila e seu uso no tratamento de câncer BR112019008810A2 (pt)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US201662415740P 2016-11-01 2016-11-01
US201662422298P 2016-11-15 2016-11-15
US201762464491P 2017-02-28 2017-02-28
PCT/US2017/059011 WO2018085198A1 (en) 2016-11-01 2017-10-30 5-halouracil-modified micrornas and their use in the treatment of cancer

Publications (1)

Publication Number Publication Date
BR112019008810A2 true BR112019008810A2 (pt) 2019-07-16

Family

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BR112019008810A BR112019008810A2 (pt) 2016-11-01 2017-10-30 micrornas modificadas com 5-halouracila e seu uso no tratamento de câncer

Country Status (12)

Country Link
US (2) US11584932B2 (pt)
EP (2) EP3534912A4 (pt)
JP (2) JP7130639B2 (pt)
KR (2) KR102502248B1 (pt)
CN (2) CN110290794A (pt)
AU (2) AU2017353907B2 (pt)
BR (1) BR112019008810A2 (pt)
CA (1) CA3042401A1 (pt)
IL (1) IL282836A (pt)
MX (1) MX2019005101A (pt)
SG (1) SG11202104571RA (pt)
WO (2) WO2018085198A1 (pt)

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CN110290794A (zh) * 2016-11-01 2019-09-27 纽约州州立大学研究基金会 5-卤代尿嘧啶修饰的微rna及其在癌症治疗中的用途
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