BR112018013808A2 - dinucleotídeos cíclicos para o tratamento de condições associadas à atividade de sting, tal como câncer - Google Patents
dinucleotídeos cíclicos para o tratamento de condições associadas à atividade de sting, tal como câncerInfo
- Publication number
- BR112018013808A2 BR112018013808A2 BR112018013808-8A BR112018013808A BR112018013808A2 BR 112018013808 A2 BR112018013808 A2 BR 112018013808A2 BR 112018013808 A BR112018013808 A BR 112018013808A BR 112018013808 A2 BR112018013808 A2 BR 112018013808A2
- Authority
- BR
- Brazil
- Prior art keywords
- cancer
- treatment
- conditions associated
- cyclic dinucleotides
- sting activity
- Prior art date
Links
- 206010028980 Neoplasm Diseases 0.000 title abstract 2
- 201000011510 cancer Diseases 0.000 title abstract 2
- 101150037787 Sting gene Proteins 0.000 title 1
- 101150060741 Sting1 gene Proteins 0.000 title 1
- 125000004122 cyclic group Chemical group 0.000 title 1
- 108010050904 Interferons Proteins 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7084—Compounds having two nucleosides or nucleotides, e.g. nicotinamide-adenine dinucleotide, flavine-adenine dinucleotide
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
- A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
- C07H21/02—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids with ribosyl as saccharide radical
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
- C07K16/2818—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against CD28 or CD152
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
Abstract
a presente descrição refere-se a compostos de dinucleotídeos que modulam a atividade do estimulador de gene de interferon (sting) para uso, por exemplo, no tratamento de câncer. a presente descrição também apresenta composições, bem como outros métodos de uso e fabricação das mesmas (fórmula (a)). a e b são cada um independentemente selecionados a partir do grupo que consiste nas fórmulas (i), (ii), (iii) e (iv). .
Applications Claiming Priority (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201662277273P | 2016-01-11 | 2016-01-11 | |
US62/277,273 | 2016-01-11 | ||
US201662436759P | 2016-12-20 | 2016-12-20 | |
US62/436,759 | 2016-12-20 | ||
PCT/US2017/013066 WO2017123669A1 (en) | 2016-01-11 | 2017-01-11 | Cyclic dinucleotides for treating conditions associated with sting activity such as cancer |
Publications (1)
Publication Number | Publication Date |
---|---|
BR112018013808A2 true BR112018013808A2 (pt) | 2018-12-11 |
Family
ID=58010371
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR112018013808-8A BR112018013808A2 (pt) | 2016-01-11 | 2017-01-11 | dinucleotídeos cíclicos para o tratamento de condições associadas à atividade de sting, tal como câncer |
Country Status (17)
Country | Link |
---|---|
US (3) | US10604542B2 (pt) |
EP (1) | EP3402801A1 (pt) |
JP (1) | JP6867395B2 (pt) |
KR (1) | KR20180097751A (pt) |
CN (1) | CN109451740B (pt) |
AU (1) | AU2017207757B2 (pt) |
BR (1) | BR112018013808A2 (pt) |
CA (1) | CA3011528A1 (pt) |
CL (1) | CL2018001870A1 (pt) |
CO (1) | CO2018008196A2 (pt) |
EA (1) | EA036421B1 (pt) |
IL (1) | IL260427B (pt) |
MX (1) | MX2018008266A (pt) |
MY (1) | MY194058A (pt) |
PE (1) | PE20181330A1 (pt) |
SG (1) | SG11201805888SA (pt) |
WO (1) | WO2017123669A1 (pt) |
Families Citing this family (68)
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EP3344644A4 (en) | 2015-08-13 | 2019-02-27 | Merck Sharp & Dohme Corp. | CYCLIC DI-NUCLEOTIDE COMPOUNDS AS STING AGONISTS |
US11453697B1 (en) | 2015-08-13 | 2022-09-27 | Merck Sharp & Dohme Llc | Cyclic di-nucleotide compounds as sting agonists |
CN109451740B (zh) * | 2016-01-11 | 2022-09-02 | 先天肿瘤免疫公司 | 用于治疗与sting活性相关的病症诸如癌症的环状二核苷酸 |
KR102530488B1 (ko) | 2016-03-18 | 2023-05-08 | 이뮨 센서, 엘엘씨 | 사이클릭 디-뉴클레오티드 화합물 및 사용 방법 |
US11098077B2 (en) | 2016-07-05 | 2021-08-24 | Chinook Therapeutics, Inc. | Locked nucleic acid cyclic dinucleotide compounds and uses thereof |
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WO2019027857A1 (en) | 2017-08-04 | 2019-02-07 | Merck Sharp & Dohme Corp. | COMBINATIONS OF PD-1 ANTAGONISTS AND STING BENZO [B] THIOPHENIC AGONISTS FOR THE TREATMENT OF CANCER |
WO2019027858A1 (en) | 2017-08-04 | 2019-02-07 | Merck Sharp & Dohme Corp. | BENZO [B] STING THIOPHEN AGONISTS FOR THE TREATMENT OF CANCER |
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WO2019051489A1 (en) | 2017-09-11 | 2019-03-14 | Sperovie Biosciences, Inc. | COMPOUNDS, COMPOSITIONS AND METHODS OF TREATING DISEASE |
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US10966999B2 (en) | 2017-12-20 | 2021-04-06 | Institute Of Organic Chemistry And Biochemistry Ascr, V.V.I. | 3′3′ cyclic dinucleotides with phosphonate bond activating the sting adaptor protein |
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JP7098748B2 (ja) | 2017-12-20 | 2022-07-11 | インスティチュート オブ オーガニック ケミストリー アンド バイオケミストリー エーエスシーアール,ヴイ.ヴイ.アイ. | Stingアダプタータンパク質を活性化するホスホン酸結合を有する2’3’環状ジヌクレオチド |
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KR20210099065A (ko) * | 2018-12-04 | 2021-08-11 | 브리스톨-마이어스 스큅 컴퍼니 | 시클릭 디뉴클레오티드의 제조 방법 |
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KR102530488B1 (ko) | 2016-03-18 | 2023-05-08 | 이뮨 센서, 엘엘씨 | 사이클릭 디-뉴클레오티드 화합물 및 사용 방법 |
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2017
- 2017-01-11 CN CN201780015198.2A patent/CN109451740B/zh active Active
- 2017-01-11 AU AU2017207757A patent/AU2017207757B2/en active Active
- 2017-01-11 PE PE2018001267A patent/PE20181330A1/es unknown
- 2017-01-11 JP JP2018536116A patent/JP6867395B2/ja active Active
- 2017-01-11 WO PCT/US2017/013066 patent/WO2017123669A1/en active Application Filing
- 2017-01-11 SG SG11201805888SA patent/SG11201805888SA/en unknown
- 2017-01-11 EA EA201891565A patent/EA036421B1/ru not_active IP Right Cessation
- 2017-01-11 MX MX2018008266A patent/MX2018008266A/es unknown
- 2017-01-11 CA CA3011528A patent/CA3011528A1/en active Pending
- 2017-01-11 EP EP17704338.7A patent/EP3402801A1/en active Pending
- 2017-01-11 BR BR112018013808-8A patent/BR112018013808A2/pt active Search and Examination
- 2017-01-11 US US15/748,685 patent/US10604542B2/en active Active
- 2017-01-11 MY MYPI2018702369A patent/MY194058A/en unknown
- 2017-01-11 KR KR1020187022863A patent/KR20180097751A/ko not_active Application Discontinuation
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2018
- 2018-07-04 IL IL260427A patent/IL260427B/en active IP Right Grant
- 2018-07-10 CL CL2018001870A patent/CL2018001870A1/es unknown
- 2018-08-02 CO CONC2018/0008196A patent/CO2018008196A2/es unknown
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2020
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US10604542B2 (en) | 2020-03-31 |
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KR20180097751A (ko) | 2018-08-31 |
IL260427B (en) | 2021-03-25 |
SG11201805888SA (en) | 2018-08-30 |
EA201891565A1 (ru) | 2019-01-31 |
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US10961270B2 (en) | 2021-03-30 |
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US11505571B2 (en) | 2022-11-22 |
EA036421B1 (ru) | 2020-11-09 |
MX2018008266A (es) | 2019-01-31 |
JP6867395B2 (ja) | 2021-04-28 |
CN109451740B (zh) | 2022-09-02 |
MY194058A (en) | 2022-11-10 |
CA3011528A1 (en) | 2017-07-20 |
EP3402801A1 (en) | 2018-11-21 |
CO2018008196A2 (es) | 2018-08-10 |
PE20181330A1 (es) | 2018-08-20 |
WO2017123669A1 (en) | 2017-07-20 |
CN109451740A (zh) | 2019-03-08 |
CL2018001870A1 (es) | 2018-11-30 |
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