BR112018007538A2 - células exterminadoras naturais e células ilc3 e usos das mesmas - Google Patents
células exterminadoras naturais e células ilc3 e usos das mesmasInfo
- Publication number
- BR112018007538A2 BR112018007538A2 BR112018007538A BR112018007538A BR112018007538A2 BR 112018007538 A2 BR112018007538 A2 BR 112018007538A2 BR 112018007538 A BR112018007538 A BR 112018007538A BR 112018007538 A BR112018007538 A BR 112018007538A BR 112018007538 A2 BR112018007538 A2 BR 112018007538A2
- Authority
- BR
- Brazil
- Prior art keywords
- cells
- ilc3
- natural killer
- cell
- stage
- Prior art date
Links
- 210000004027 cell Anatomy 0.000 title abstract 6
- 210000000822 natural killer cell Anatomy 0.000 title abstract 4
- 206010028980 Neoplasm Diseases 0.000 abstract 2
- 208000036142 Viral infection Diseases 0.000 abstract 2
- 201000011510 cancer Diseases 0.000 abstract 2
- 230000009385 viral infection Effects 0.000 abstract 2
- 230000004663 cell proliferation Effects 0.000 abstract 1
- 230000004069 differentiation Effects 0.000 abstract 1
- 210000000130 stem cell Anatomy 0.000 abstract 1
- 210000004881 tumor cell Anatomy 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
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- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0634—Cells from the blood or the immune system
- C12N5/0646—Natural killers cells [NK], NKT cells
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/14—Blood; Artificial blood
- A61K35/17—Lymphocytes; B-cells; T-cells; Natural killer cells; Interferon-activated or cytokine-activated lymphocytes
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/46—Cellular immunotherapy
- A61K39/461—Cellular immunotherapy characterised by the cell type used
- A61K39/4613—Natural-killer cells [NK or NK-T]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/46—Cellular immunotherapy
- A61K39/464—Cellular immunotherapy characterised by the antigen targeted or presented
- A61K39/4643—Vertebrate antigens
- A61K39/4644—Cancer antigens
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- A—HUMAN NECESSITIES
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- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
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- A—HUMAN NECESSITIES
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- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- C12N5/0602—Vertebrate cells
- C12N5/0634—Cells from the blood or the immune system
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- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
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- C12N2501/125—Stem cell factor [SCF], c-kit ligand [KL]
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- C12N2501/22—Colony stimulating factors (G-CSF, GM-CSF)
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- C12N2501/2302—Interleukin-2 (IL-2)
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- C12N2501/2306—Interleukin-6 (IL-6)
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- C12N2506/00—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells
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- C12N2506/00—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells
- C12N2506/11—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells from blood or immune system cells
Abstract
a presente invenção refere-se a métodos de produção de células exterminadoras naturais (nk) e/ou células ilc3 usando um método de expansão em três estágios e método de diferenciação com meios compreendendo fatores de mobilização de células-tronco. também são providos no presente documento meios de supressão da proliferação de célula tumoral usando as células nk e/ou células ilc3 e as populações de célula nk e/ou célula ilc3 produzidas pelos métodos em três estágios descritos no presente documento, assim como métodos de tratamento de indivíduos que têm câncer ou uma infecção viral, compreendendo administrar as células nk e/ou células ilc3 e as populações de célula nk e/ou célula ilc3 produzidas pelos métodos em três estágios descritos no presente documento para um indivíduo que tem cancer ou infecção viral.
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201562242246P | 2015-10-15 | 2015-10-15 | |
US201562272984P | 2015-12-30 | 2015-12-30 | |
US201662403571P | 2016-10-03 | 2016-10-03 | |
PCT/US2016/056988 WO2017066530A1 (en) | 2015-10-15 | 2016-10-14 | Natural killer cells and ilc3 cells and uses thereof |
Publications (1)
Publication Number | Publication Date |
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BR112018007538A2 true BR112018007538A2 (pt) | 2018-10-23 |
Family
ID=58517926
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR112018007538A BR112018007538A2 (pt) | 2015-10-15 | 2016-10-14 | células exterminadoras naturais e células ilc3 e usos das mesmas |
Country Status (17)
Country | Link |
---|---|
US (2) | US20180346877A1 (pt) |
EP (1) | EP3362075B1 (pt) |
JP (3) | JP2018535666A (pt) |
KR (1) | KR20180059555A (pt) |
CN (1) | CN109310710A (pt) |
AU (1) | AU2016340005B2 (pt) |
BR (1) | BR112018007538A2 (pt) |
CA (1) | CA3002066A1 (pt) |
CO (1) | CO2018004937A2 (pt) |
EA (1) | EA201890960A1 (pt) |
IL (1) | IL258666A (pt) |
MX (1) | MX2018004600A (pt) |
MY (1) | MY201637A (pt) |
NZ (1) | NZ741612A (pt) |
SG (2) | SG10201912576PA (pt) |
TW (1) | TW201732037A (pt) |
WO (1) | WO2017066530A1 (pt) |
Families Citing this family (18)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
TWI794171B (zh) | 2016-05-11 | 2023-03-01 | 美商滬亞生物國際有限公司 | Hdac抑制劑與pd-l1抑制劑之組合治療 |
TWI808055B (zh) | 2016-05-11 | 2023-07-11 | 美商滬亞生物國際有限公司 | Hdac 抑制劑與 pd-1 抑制劑之組合治療 |
US20200246393A1 (en) * | 2017-09-28 | 2020-08-06 | Celularity, Inc. | Tumor suppression using human placenta-derived intermediate natural killer (pink) cells in combination with an antibody |
JP7467358B2 (ja) * | 2018-02-20 | 2024-04-15 | ウニヴェルシテ・ドゥ・モントリオール | 免疫応答を媒介するin vivoでのNK細胞およびDC細胞の拡大 |
CN108486054B (zh) * | 2018-04-12 | 2022-04-19 | 平安爱普德(北京)生物技术有限公司 | 一种体外扩增i型天然细胞毒性淋巴细胞ilc1/nk的方法 |
WO2020113182A1 (en) * | 2018-11-30 | 2020-06-04 | Celularity, Inc. | Expansion of natural killer cells and ilc3 cells with novel aromatic compounds |
WO2020231200A1 (ko) * | 2019-05-15 | 2020-11-19 | 오정훈 | 효율적 자연살해세포 배양방법 및 이의 배지첨가 키트 |
WO2020252464A1 (en) * | 2019-06-14 | 2020-12-17 | Celularity Inc. | Populations of natural killer cells for treating cancers |
AU2020321953A1 (en) * | 2019-07-29 | 2022-02-24 | Deverra Therapeutics Inc. | NK cell composition and preparations for immunotherapy and methods for their production |
CN114845719A (zh) * | 2019-12-18 | 2022-08-02 | 蒙特利尔大学 | 作为抗癌化合物的cullin 3连接蛋白kbtbd4的调节剂 |
WO2021155312A1 (en) * | 2020-01-29 | 2021-08-05 | Celularity Inc. | Placental derived natural killer cells for treatment of coronavirus infections |
US20210260115A1 (en) * | 2020-02-21 | 2021-08-26 | FullHope Biomedical Co., Ltd. | Modified natural killer cells, pharmaceutical composition, manufacturing method thereof, and method of using the same |
JP2021136883A (ja) * | 2020-03-02 | 2021-09-16 | 株式会社ガイアバイオメディシン | 高活性nk細胞の処理方法 |
CN112285083B (zh) * | 2020-10-28 | 2022-01-07 | 上海睿钰生物科技有限公司 | 一种细胞杀伤效力的评价方法 |
CN112251406B (zh) * | 2020-10-30 | 2023-06-09 | 曹峰林 | 一种nk细胞活化阶段的外泌体分选方法 |
WO2022113056A1 (en) | 2020-11-30 | 2022-06-02 | Crispr Therapeutics Ag | Gene-edited natural killer cells |
EP4271798A1 (en) | 2020-12-30 | 2023-11-08 | CRISPR Therapeutics AG | Compositions and methods for differentiating stem cells into nk cells |
AU2022342919A1 (en) * | 2021-09-08 | 2024-03-14 | Gaia Biomedicine Inc. | Method for treating cells |
Family Cites Families (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5709859A (en) * | 1991-01-24 | 1998-01-20 | Bristol-Myers Squibb Company | Mixed specificity fusion proteins |
PE20100362A1 (es) * | 2008-10-30 | 2010-05-27 | Irm Llc | Derivados de purina que expanden las celulas madre hematopoyeticas |
US9862928B2 (en) * | 2010-12-03 | 2018-01-09 | Regents Of The University Of Minnesota | Generation of natural killer cells and lymphoid tissue inducer-like (LTi-like) NK-22 cells |
DK2686421T3 (da) * | 2011-03-18 | 2021-03-08 | Glycostem Therapeutics B V | Generering af nk-celler og nk-celleforløbere |
BR112014018524B1 (pt) * | 2012-01-27 | 2023-03-28 | Universite De Montreal | Derivados de pirimido [4,5-b]indol, seu usos, composição farmaceutica, e método in vivo ou ex vivo para aumen-tar as células estaminais e/ou progenitoras |
WO2013119118A1 (en) | 2012-02-08 | 2013-08-15 | Ipd-Therapeutics B.V. | Ex vivo nk cell differentiation from cd34+ hematopoietic cells |
JP2015526088A (ja) * | 2012-08-13 | 2015-09-10 | アントフロゲネシス コーポレーション | ナチュラルキラー細胞及びその使用 |
US9074186B2 (en) * | 2012-08-15 | 2015-07-07 | Boston Medical Center Corporation | Production of red blood cells and platelets from stem cells |
EP3041494A4 (en) * | 2013-09-05 | 2017-10-18 | Sanford-Burnham Medical Research Institute | Modulation of gamma delta t cells |
AU2015374055A1 (en) * | 2014-12-31 | 2017-07-20 | Celularity Inc. | Natural killer cells and uses thereof |
US20180237749A1 (en) * | 2015-09-15 | 2018-08-23 | Stichting Katholieke Universiteit | Improved method for ex vivo expansion CD34+HSPCs into NK cells using an aryl hydrocarbon receptor antagonist |
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2016
- 2016-10-14 NZ NZ741612A patent/NZ741612A/en unknown
- 2016-10-14 SG SG10201912576PA patent/SG10201912576PA/en unknown
- 2016-10-14 KR KR1020187013666A patent/KR20180059555A/ko not_active Application Discontinuation
- 2016-10-14 SG SG11201803117YA patent/SG11201803117YA/en unknown
- 2016-10-14 US US15/768,505 patent/US20180346877A1/en not_active Abandoned
- 2016-10-14 AU AU2016340005A patent/AU2016340005B2/en active Active
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TW201732037A (zh) | 2017-09-16 |
AU2016340005A1 (en) | 2018-05-10 |
EP3362075B1 (en) | 2023-06-07 |
CN109310710A (zh) | 2019-02-05 |
SG11201803117YA (en) | 2018-05-30 |
KR20180059555A (ko) | 2018-06-04 |
CA3002066A1 (en) | 2017-04-20 |
MX2018004600A (es) | 2019-09-04 |
WO2017066530A1 (en) | 2017-04-20 |
US20230142803A1 (en) | 2023-05-11 |
SG10201912576PA (en) | 2020-02-27 |
NZ741612A (en) | 2022-12-23 |
JP2018535666A (ja) | 2018-12-06 |
EP3362075A1 (en) | 2018-08-22 |
EA201890960A1 (ru) | 2018-10-31 |
EP3362075A4 (en) | 2019-04-17 |
JP2023171766A (ja) | 2023-12-05 |
US20180346877A1 (en) | 2018-12-06 |
AU2016340005B2 (en) | 2023-09-07 |
MY201637A (en) | 2024-03-06 |
CO2018004937A2 (es) | 2018-09-28 |
JP2022023148A (ja) | 2022-02-07 |
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