CO2018008196A2 - Dinucleótidos cíclicos para tratar condiciones asociadas con actividad del estimulador de genes del interferón (sting) tales como cáncer - Google Patents
Dinucleótidos cíclicos para tratar condiciones asociadas con actividad del estimulador de genes del interferón (sting) tales como cáncerInfo
- Publication number
- CO2018008196A2 CO2018008196A2 CONC2018/0008196A CO2018008196A CO2018008196A2 CO 2018008196 A2 CO2018008196 A2 CO 2018008196A2 CO 2018008196 A CO2018008196 A CO 2018008196A CO 2018008196 A2 CO2018008196 A2 CO 2018008196A2
- Authority
- CO
- Colombia
- Prior art keywords
- sting
- cancer
- activity
- interferon gene
- conditions associated
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7084—Compounds having two nucleosides or nucleotides, e.g. nicotinamide-adenine dinucleotide, flavine-adenine dinucleotide
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
- A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
- C07H21/02—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids with ribosyl as saccharide radical
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
- C07K16/2818—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against CD28 or CD152
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
Abstract
Esta descripción presenta compuestos de dinucleótidos que modulan la actividad del Estimulador de Genes del Interferón (STING), para uso por ejemplo en el tratamiento del cáncer. Esta descripción también presenta las composiciones así como otros métodos de uso y elaboración de la mismas (FórmulaA)). A y B se seleccionan cada uno independientemente del grupo que consiste de las Fórmulas (i), (ii), (iii) y (iv).
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201662277273P | 2016-01-11 | 2016-01-11 | |
US201662436759P | 2016-12-20 | 2016-12-20 | |
PCT/US2017/013066 WO2017123669A1 (en) | 2016-01-11 | 2017-01-11 | Cyclic dinucleotides for treating conditions associated with sting activity such as cancer |
Publications (1)
Publication Number | Publication Date |
---|---|
CO2018008196A2 true CO2018008196A2 (es) | 2018-08-10 |
Family
ID=58010371
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CONC2018/0008196A CO2018008196A2 (es) | 2016-01-11 | 2018-08-02 | Dinucleótidos cíclicos para tratar condiciones asociadas con actividad del estimulador de genes del interferón (sting) tales como cáncer |
Country Status (17)
Country | Link |
---|---|
US (3) | US10604542B2 (es) |
EP (1) | EP3402801A1 (es) |
JP (1) | JP6867395B2 (es) |
KR (1) | KR20180097751A (es) |
CN (1) | CN109451740B (es) |
AU (1) | AU2017207757B2 (es) |
BR (1) | BR112018013808A2 (es) |
CA (1) | CA3011528A1 (es) |
CL (1) | CL2018001870A1 (es) |
CO (1) | CO2018008196A2 (es) |
EA (1) | EA036421B1 (es) |
IL (1) | IL260427B (es) |
MX (1) | MX2018008266A (es) |
MY (1) | MY194058A (es) |
PE (1) | PE20181330A1 (es) |
SG (1) | SG11201805888SA (es) |
WO (1) | WO2017123669A1 (es) |
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JO3746B1 (ar) | 2015-03-10 | 2021-01-31 | Aduro Biotech Inc | تركيبات وطرق لتنشيط الإشارات المعتمدة على "منبه أو تحفيز جين انترفيرون" |
WO2017027645A1 (en) | 2015-08-13 | 2017-02-16 | Merck Sharp & Dohme Corp. | Cyclic di-nucleotide compounds as sting agonists |
US11453697B1 (en) | 2015-08-13 | 2022-09-27 | Merck Sharp & Dohme Llc | Cyclic di-nucleotide compounds as sting agonists |
PE20181330A1 (es) * | 2016-01-11 | 2018-08-20 | Innate Tumor Immunity Inc | Dinucleotidos ciclicos para tratar condiciones asociadas con actividad del estimulador de genes del interferon (sting) tales como cancer |
WO2017161349A1 (en) | 2016-03-18 | 2017-09-21 | Immune Sensor, Llc | Cyclic di-nucleotide compounds and methods of use |
WO2018009466A1 (en) | 2016-07-05 | 2018-01-11 | Aduro Biotech, Inc. | Locked nucleic acid cyclic dinucleotide compounds and uses thereof |
AU2017293781B2 (en) | 2016-07-06 | 2022-12-22 | F-star Therapeutics, Inc. | Compounds, compositions, and methods for the treatment of disease |
WO2018045058A1 (en) | 2016-08-30 | 2018-03-08 | Dana-Farber Cancer Institute, Inc. | Drug delivery compositions and uses thereof |
UA125223C2 (uk) | 2016-10-04 | 2022-02-02 | Мерк Шарп І Доум Корп. | СПОЛУКИ БЕНЗО[b]ТІОФЕНУ ЯК АГОНІСТИ STING |
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US11466047B2 (en) | 2017-05-12 | 2022-10-11 | Merck Sharp & Dohme Llc | Cyclic di-nucleotide compounds as sting agonists |
US11259980B2 (en) | 2017-07-31 | 2022-03-01 | Arizona Board Of Regents On Behalf Of Arizona State University | Soft inflatable exosuit for knee rehabilitation |
US11285131B2 (en) | 2017-08-04 | 2022-03-29 | Merck Sharp & Dohme Corp. | Benzo[b]thiophene STING agonists for cancer treatment |
RU2020109328A (ru) | 2017-08-04 | 2021-09-06 | Мерк Шарп И Доум Корп. | Комбинации антагонистов pd-1 и бензо[b]тиофеновых агонистов sting для лечения рака |
RU2020112502A (ru) | 2017-08-30 | 2021-10-01 | Бейцзин Сюаньи Фармасайенсиз Ко., Лтд. | Циклические динуклеотиды в качестве стимулятора модуляторов генов интерферона |
JP7316263B2 (ja) * | 2017-08-31 | 2023-07-27 | ブリストル-マイヤーズ スクイブ カンパニー | 抗癌剤としての環状ジヌクレオチド |
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US11707531B2 (en) | 2017-09-11 | 2023-07-25 | F-star Therapeutics, Inc. | Compounds, compositions, and methods for the treatment of disease |
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WO2017161349A1 (en) | 2016-03-18 | 2017-09-21 | Immune Sensor, Llc | Cyclic di-nucleotide compounds and methods of use |
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2017
- 2017-01-11 PE PE2018001267A patent/PE20181330A1/es unknown
- 2017-01-11 JP JP2018536116A patent/JP6867395B2/ja active Active
- 2017-01-11 BR BR112018013808-8A patent/BR112018013808A2/pt active Search and Examination
- 2017-01-11 CA CA3011528A patent/CA3011528A1/en active Pending
- 2017-01-11 EA EA201891565A patent/EA036421B1/ru not_active IP Right Cessation
- 2017-01-11 US US15/748,685 patent/US10604542B2/en active Active
- 2017-01-11 AU AU2017207757A patent/AU2017207757B2/en active Active
- 2017-01-11 MY MYPI2018702369A patent/MY194058A/en unknown
- 2017-01-11 SG SG11201805888SA patent/SG11201805888SA/en unknown
- 2017-01-11 WO PCT/US2017/013066 patent/WO2017123669A1/en active Application Filing
- 2017-01-11 EP EP17704338.7A patent/EP3402801A1/en active Pending
- 2017-01-11 KR KR1020187022863A patent/KR20180097751A/ko not_active Application Discontinuation
- 2017-01-11 MX MX2018008266A patent/MX2018008266A/es unknown
- 2017-01-11 CN CN201780015198.2A patent/CN109451740B/zh active Active
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2018
- 2018-07-04 IL IL260427A patent/IL260427B/en active IP Right Grant
- 2018-07-10 CL CL2018001870A patent/CL2018001870A1/es unknown
- 2018-08-02 CO CONC2018/0008196A patent/CO2018008196A2/es unknown
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2020
- 2020-01-31 US US16/778,281 patent/US10961270B2/en active Active
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2021
- 2021-01-28 US US17/160,578 patent/US11505571B2/en active Active
Also Published As
Publication number | Publication date |
---|---|
IL260427B (en) | 2021-03-25 |
BR112018013808A2 (pt) | 2018-12-11 |
US20200165288A1 (en) | 2020-05-28 |
SG11201805888SA (en) | 2018-08-30 |
KR20180097751A (ko) | 2018-08-31 |
US20190016750A1 (en) | 2019-01-17 |
EA036421B1 (ru) | 2020-11-09 |
US10604542B2 (en) | 2020-03-31 |
US20210147467A1 (en) | 2021-05-20 |
CA3011528A1 (en) | 2017-07-20 |
US10961270B2 (en) | 2021-03-30 |
EP3402801A1 (en) | 2018-11-21 |
PE20181330A1 (es) | 2018-08-20 |
JP2019501204A (ja) | 2019-01-17 |
CN109451740B (zh) | 2022-09-02 |
AU2017207757B2 (en) | 2021-05-27 |
AU2017207757A1 (en) | 2018-08-23 |
US11505571B2 (en) | 2022-11-22 |
WO2017123669A1 (en) | 2017-07-20 |
CN109451740A (zh) | 2019-03-08 |
EA201891565A1 (ru) | 2019-01-31 |
MX2018008266A (es) | 2019-01-31 |
JP6867395B2 (ja) | 2021-04-28 |
CL2018001870A1 (es) | 2018-11-30 |
MY194058A (en) | 2022-11-10 |
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