BR112017002629A2 - decoys de oligonucleotídeo para o tratamento de dor - Google Patents

decoys de oligonucleotídeo para o tratamento de dor

Info

Publication number
BR112017002629A2
BR112017002629A2 BR112017002629-5A BR112017002629A BR112017002629A2 BR 112017002629 A2 BR112017002629 A2 BR 112017002629A2 BR 112017002629 A BR112017002629 A BR 112017002629A BR 112017002629 A2 BR112017002629 A2 BR 112017002629A2
Authority
BR
Brazil
Prior art keywords
oligonucleotide decoys
pain treatment
decoys
double
nucleic acids
Prior art date
Application number
BR112017002629-5A
Other languages
English (en)
Inventor
Mamet Julien
Orr Rick
Manning Don
Harris Scott
Martin William
Original Assignee
Adynxx, Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Adynxx, Inc. filed Critical Adynxx, Inc.
Publication of BR112017002629A2 publication Critical patent/BR112017002629A2/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/10—Type of nucleic acid
    • C12N2310/13—Decoys

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Epidemiology (AREA)
  • Microbiology (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Plant Pathology (AREA)
  • Biochemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

são providos agentes terapêuticos tais como os ácidos nucleicos de fita dupla, denominados decoys de oligonucleotídeo, com-posições farmacêuticas compreendendo os mesmos, e métodos relacionados para a modulação de sinalização nociceptiva, por exemplo, para prevenir e/ou tratar a dor.
BR112017002629-5A 2014-08-15 2015-08-14 decoys de oligonucleotídeo para o tratamento de dor BR112017002629A2 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201462037996P 2014-08-15 2014-08-15
US62/037,996 2014-08-15
PCT/US2015/045268 WO2016025829A1 (en) 2014-08-15 2015-08-14 Oligonucleotide decoys for the treatment of pain

Publications (1)

Publication Number Publication Date
BR112017002629A2 true BR112017002629A2 (pt) 2018-02-20

Family

ID=55304669

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112017002629-5A BR112017002629A2 (pt) 2014-08-15 2015-08-14 decoys de oligonucleotídeo para o tratamento de dor

Country Status (11)

Country Link
US (2) US10287583B2 (pt)
EP (2) EP3180434B1 (pt)
JP (2) JP6705807B2 (pt)
CN (1) CN106661578B (pt)
AU (1) AU2015301491A1 (pt)
BR (1) BR112017002629A2 (pt)
CA (1) CA2957250A1 (pt)
ES (1) ES2750689T3 (pt)
PT (1) PT3180434T (pt)
RU (1) RU2017108238A (pt)
WO (1) WO2016025829A1 (pt)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP5646320B2 (ja) 2007-05-11 2014-12-24 アダイニクス， インコーポレイテッド 遺伝子発現と疼痛
CA2872901A1 (en) 2012-05-10 2013-11-14 Adynxx, Inc. Formulations for the delivery of active ingredients
JP6705807B2 (ja) 2014-08-15 2020-06-03 エーダイニクス インコーポレイテッド 疼痛を治療するためのオリゴヌクレオチドデコイ
FR3029450B1 (fr) * 2014-12-03 2017-11-03 Pole De Plasturgie De Lest Dispositif de moulage pour la fabrication de pieces en materiau composite a partir de resine polymere liquide par injection haute pression.
EP3902550A4 (en) * 2018-12-24 2023-09-06 The Regents of the University of California TREATMENT OF SPINE DISEASES WITH CHIMERA DECOY
EP4196587A2 (en) * 2020-08-13 2023-06-21 Nevada Research & Innovation Corporation Klf11 sirna for treatment of diabetes and obesity
WO2023070072A1 (en) 2021-10-21 2023-04-27 The J. David Gladstone Institutes, A Testamentary Trust Established Under The Will Of J. David Gladstone Retroelement-generated transcription factor decoys

Family Cites Families (91)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6410516B1 (en) 1986-01-09 2002-06-25 President & Fellows Of Harvard College Nuclear factors associated with transcriptional regulation
US5206152A (en) 1988-04-08 1993-04-27 Arch Development Corporation Cloning and expression of early growth regulatory protein genes
DE3815221C2 (de) 1988-05-04 1995-06-29 Gradinger F Hermes Pharma Verwendung einer Retinol- und/oder Retinsäureester enthaltenden pharmazeutischen Zubereitung zur Inhalation zur Einwirkung auf die Schleimhäute des Tracheo-Bronchialtraktes einschließlich der Lungenalveolen
KR100225087B1 (ko) 1990-03-23 1999-10-15 한스 발터라벤 피타아제의 식물내 발현
US5272056A (en) 1991-01-03 1993-12-21 The Research Foundation Of State University Of New York Modification of DNA and oligonucleotides using metal complexes of polyaza ligands
US5683985A (en) 1991-04-18 1997-11-04 The Salk Institute For Biological Studies Oligonucleotide decoys and methods relating thereto
FR2675803B1 (fr) 1991-04-25 1996-09-06 Genset Sa Oligonucleotides fermes, antisens et sens et leurs applications.
JPH07501204A (ja) 1991-06-28 1995-02-09 マサチューセッツ インスティテュート オブ テクノロジー 局所的オリゴヌクレオチド療法
WO1995004064A1 (en) 1993-07-29 1995-02-09 The Regents Of The University Of California Polynucleotide decoys that ihnibit mhc-ii expression and uses thereof
EP1340505A3 (en) 1993-10-29 2004-07-14 The Brigham And Women's Hospital, Inc. Therapeutic use of cis-element decoys in vivo
JP3392143B2 (ja) 1994-11-17 2003-03-31 大鵬薬品工業株式会社 二本鎖オリゴヌクレオチド及びこれを有効成分とする制癌剤
AU5369396A (en) 1995-03-23 1996-10-08 Research Foundation Of The State University Of New York, The Rest protein and dna
KR100449677B1 (ko) 1995-05-11 2004-11-20 어플라이드 리서치 시스템스 Il－6 활성 저해 물질
DE69636997T2 (de) 1995-05-12 2007-07-12 Anges MG Inc., Ibaraki HEILUNG UND VORBEUGUNG VON DURCH NF-kappaB VERURSACHTEN ERKRANKUNGEN
GB9515356D0 (en) 1995-07-26 1995-09-20 Medical Res Council Improvements in or relating to delivery of nucleic acid
US6265389B1 (en) 1995-08-31 2001-07-24 Alkermes Controlled Therapeutics, Inc. Microencapsulation and sustained release of oligonucleotides
US6245747B1 (en) 1996-03-12 2001-06-12 The Board Of Regents Of The University Of Nebraska Targeted site specific antisense oligodeoxynucleotide delivery method
DE69738454D1 (de) 1996-05-20 2008-02-21 Us Gov Health & Human Serv Oligonukleotide welche spezifisch retrovirale nukleokapsid-proteine binden
US6022863A (en) 1996-05-21 2000-02-08 Yale University Regulation of gene expression
DE69839147T2 (de) 1997-06-12 2009-02-19 Novartis International Pharmaceutical Ltd. Künstliche antikörperpolypeptide
EP1008352A4 (en) 1997-07-04 2005-03-16 Fujisawa Pharmaceutical Co Cerebrospinal PROTECTOR
JP3667047B2 (ja) 1997-09-12 2005-07-06 キヤノン株式会社 人工核酸およびその製造方法、デオキシリボフラノース化合物、リボフラノース化合物およびこれらの製造方法
DE19742706B4 (de) 1997-09-26 2013-07-25 Pieris Proteolab Ag Lipocalinmuteine
US6376471B1 (en) 1997-10-10 2002-04-23 Johns Hopkins University Gene delivery compositions and methods
US6060310A (en) 1997-11-24 2000-05-09 The United States Of America As Represented By The Department Of Health And Human Services Transcription factor decoy and tumor growth inhibitor
WO1999031115A1 (en) 1997-12-16 1999-06-24 The University Of Saskatchewan Conductive metal-containing nucleic acids
AUPP221098A0 (en) 1998-03-06 1998-04-02 Diatech Pty Ltd V-like domain binding molecules
DE69910202T2 (de) 1998-06-02 2004-06-17 Glaxo Group Ltd., Greenford EGR-1 zur Herstellung eines Medikamentes zur Behandlung von Wunden
US6818626B1 (en) 1998-07-17 2004-11-16 Mirus Corporation Chelating systems for use in the delivery of compounds to cells
US6423493B1 (en) 1998-10-26 2002-07-23 Board Of Regents The University Of Texas System Combinatorial selection of oligonucleotide aptamers
US6008048A (en) 1998-12-04 1999-12-28 Isis Pharmaceuticals Inc. Antisense inhibition of EGR-1 expression
US7115396B2 (en) 1998-12-10 2006-10-03 Compound Therapeutics, Inc. Protein scaffolds for antibody mimics and other binding proteins
US7160869B2 (en) 1998-12-16 2007-01-09 University Of Saskatchewan Biologically active metal-containing nucleic acids
US6140128A (en) 1998-12-23 2000-10-31 Genentech, Inc. Preparation of calcium phosphate transfectacons
US6395029B1 (en) 1999-01-19 2002-05-28 The Children's Hospital Of Philadelphia Sustained delivery of polyionic bioactive agents
US6333408B1 (en) 1999-03-08 2001-12-25 Kureha Chemical Industry Co., Ltd. Oligonucleotides inhibitors of PAI-1 MRNA
FR2790955B1 (fr) 1999-03-19 2003-01-17 Assist Publ Hopitaux De Paris Utilisation d'oligonucleotides stabilises comme principe actif antitumoral
US6387620B1 (en) 1999-07-28 2002-05-14 Gilead Sciences, Inc. Transcription-free selex
US6599741B1 (en) 1999-09-14 2003-07-29 Avontec Gmbh Modulating transcription of genes in vascular cells
US6927027B2 (en) 1999-12-21 2005-08-09 Ingeneus Corporation Nucleic acid multiplex formation
US6969704B1 (en) 2000-08-25 2005-11-29 The Trustees Of Columbia University In The City Of New York Methods for suppressing early growth response—1protein (Egr-1) to reduce vascular injury in a subject
AU2002218166A1 (en) 2000-09-08 2002-03-22 Universitat Zurich Collections of repeat proteins comprising repeat modules
US6376190B1 (en) 2000-09-22 2002-04-23 Somalogic, Inc. Modified SELEX processes without purified protein
DE10049549A1 (de) * 2000-10-06 2002-05-02 Markus Hecker Modulation der Transkription pro-inflammatorischer Genprodukte
WO2002030355A2 (en) 2000-10-11 2002-04-18 Laura Kragie Composition and method of alleviating adverse side effects and/or enhancing efficacy of agents that inhibit aromatase
US6596541B2 (en) 2000-10-31 2003-07-22 Regeneron Pharmaceuticals, Inc. Methods of modifying eukaryotic cells
EP1344536A4 (en) 2000-11-24 2005-01-19 Chugai Pharmaceutical Co Ltd METHOD FOR REGULATING THE ACTIVITY OF EXPRESSION OF A GENETIC PRODUCT TRANSFERRED INTO A LIVING ORGANISM
WO2002066071A2 (en) 2001-01-03 2002-08-29 Thomas Jefferson University Treatment of tissue fibrosis by blocking the sp1 transcription factor
WO2002057480A2 (en) 2001-01-22 2002-07-25 Genta Incorporated Cell-proliferative disorder treatments using cre decoy oligomers, bcl-2 antisense and hybrid oligomers
TWI308492B (pt) 2001-02-20 2009-04-11 Anges Mg Inc
US20070122401A1 (en) 2001-03-06 2007-05-31 Andrews William H Methods and compositions for modulating telomerase reverse transcriptase (tert) expression
US20030166555A1 (en) 2001-04-02 2003-09-04 Alberini Cristina M. Methods and compositions for regulating memory consolidation
WO2002088171A2 (en) 2001-04-26 2002-11-07 Avidia Research Institute Combinatorial libraries of monomer domains
US20040175756A1 (en) 2001-04-26 2004-09-09 Avidia Research Institute Methods for using combinatorial libraries of monomer domains
US20050053973A1 (en) 2001-04-26 2005-03-10 Avidia Research Institute Novel proteins with targeted binding
EP1298141A1 (en) 2001-09-27 2003-04-02 Deutsches Krebsforschungszentrum Stiftung des öffentlichen Rechts Interleukin-4 (IL-4) promoter sequences specifically interacting with IRF-1 and IRF-2
DE10148828B4 (de) 2001-10-04 2005-05-19 Avontec Gmbh Modulation der Expression STAT-1-abhängiger Gene
US6663880B1 (en) 2001-11-30 2003-12-16 Advanced Cardiovascular Systems, Inc. Permeabilizing reagents to increase drug delivery and a method of local delivery
JP2005519917A (ja) 2002-02-01 2005-07-07 オメロス コーポレイション 軟骨分解の全身阻害のための組成物および方法
US7244592B2 (en) 2002-03-07 2007-07-17 Dyax Corp. Ligand screening and discovery
CN1240439C (zh) 2002-03-28 2006-02-08 南京凯基生物科技发展有限公司 肿瘤基因开关药物
US20070014840A1 (en) 2002-04-26 2007-01-18 In-Kyu Lee Circular dumbbell decoy oligodeoxynucleotides (cdodn) containing dna bindings sites of transcription
DE10242319A1 (de) 2002-09-12 2004-03-25 Avontec Gmbh Funkionelle Korrektur der-786C/T-Varianz des humanen eNOS-Gens
DE10257421A1 (de) 2002-12-09 2004-07-08 Grünenthal GmbH Regulatorische Elemente im 5'-Bereich des VR1-Gens
MXPA05006169A (es) 2002-12-09 2006-03-30 American Biosciences Composiciones y metodos para el suministro de agentes farmacologicos.
EP1644532A4 (en) 2003-06-30 2007-11-28 Massachusetts Inst Technology EGR GENES AS OBJECTIVES FOR DIAGNOSIS AND TREATMENT OF SCHIZOPHRENIA
WO2005027830A2 (en) 2003-09-12 2005-03-31 Virginia Commonwealth University Chimeric transcription factor decoy oligonucleotides
WO2005062854A2 (en) 2003-12-19 2005-07-14 University Of Cincinnati Polyamides for nucleic acid delivery
JP2005336081A (ja) 2004-05-26 2005-12-08 Anges Mg Inc Ｎｒ２ｂ−ｎｍｄａ受容体の再発現抑制剤
US7482158B2 (en) 2004-07-01 2009-01-27 Mathison Brian H Composite polynucleic acid therapeutics
WO2006012625A2 (en) 2004-07-22 2006-02-02 University Of Pittsburgh - Of The Commonwealth System Of Higher Education Stat3 decoy oligonucleotides and uses therefor
MX2007003167A (es) 2004-09-21 2007-05-16 Anesiva Inc Asministracion de polinucleotidos.
WO2006035434A2 (en) 2004-09-28 2006-04-06 Quark Biotech, Inc. Oligoribonucleotides and methods of use thereof for treatment of alopecia, acute renal failure and other diseases
EP1803811B1 (en) 2004-10-22 2011-05-11 AnGes MG, Inc. Chimeric (double) decoy
US20060189564A1 (en) 2004-10-22 2006-08-24 Medtronic, Inc. Methods and sequences to suppress pro-inflamatory cytokine actions locally to treat pain
US7585848B2 (en) 2005-01-11 2009-09-08 Rush University Medical Center Methods and compositions for treating, inhibiting and reversing disorders of the intervertebral disc
WO2006096498A2 (en) 2005-03-04 2006-09-14 Dana-Farber Cancer Institute, Inc. Regulation of runx1 for treatment of pain
EP2086573B1 (en) 2006-10-09 2020-11-25 Neurofluidics, Inc. Cerebrospinal fluid purification system
MX2009011218A (es) 2007-04-17 2010-02-11 Baxter Int Microparticulas de acido nucleico para administracion pulmonar.
JP5646320B2 (ja) 2007-05-11 2014-12-24 アダイニクス， インコーポレイテッド 遺伝子発現と疼痛
AU2014201462B2 (en) * 2007-05-11 2016-09-29 Adynxx, Inc. Gene expression and pain
GB0906130D0 (en) * 2008-10-03 2009-05-20 Procrata Biosystems Ltd Transcription factor decoys
US8609617B2 (en) * 2009-09-04 2013-12-17 University Of Miami KLF family members regulate intrinsic axon regeneration ability
DK2605794T3 (en) 2010-08-20 2016-10-24 Replicor Inc Oligonukleotidchelatkomplekser
US20140275211A1 (en) * 2011-06-21 2014-09-18 Alnylam Pharmaceuticals, Inc. Assays and methods for determining activity of a therapeutic agent in a subject
DK2734212T3 (da) 2011-07-20 2017-11-06 Hospira Inc Sammensætninger omfattende diclofenac til behandling af postoperativ smerte
CA2872901A1 (en) 2012-05-10 2013-11-14 Adynxx, Inc. Formulations for the delivery of active ingredients
SI2849798T1 (sl) 2012-05-18 2021-08-31 Replicor Inc. Oligonukleotidni kelatni kompleksni polipeptidni sestavki in postopki
JP6705807B2 (ja) 2014-08-15 2020-06-03 エーダイニクス インコーポレイテッド 疼痛を治療するためのオリゴヌクレオチドデコイ
US20200017853A1 (en) 2016-02-29 2020-01-16 Adynxx, Inc. Compositions and methods for pain amelioration via modification of gene expression
CA3091832A1 (en) 2018-02-23 2019-08-29 Adynxx Sub, Inc. Compositions and methods for pain amelioration in patient population that scores high on the pain catastrophizing scale

Also Published As

Publication number Publication date
RU2017108238A (ru) 2018-09-17
CN106661578A (zh) 2017-05-10
AU2015301491A1 (en) 2017-02-02
EP3180434A4 (en) 2018-04-04
US20190276825A1 (en) 2019-09-12
EP3180434B1 (en) 2019-07-17
EP3626822A1 (en) 2020-03-25
PT3180434T (pt) 2019-10-29
CA2957250A1 (en) 2016-02-18
US10287583B2 (en) 2019-05-14
CN106661578B (zh) 2020-08-04
RU2017108238A3 (pt) 2019-09-18
JP2020141688A (ja) 2020-09-10
US20170247694A1 (en) 2017-08-31
EP3180434A1 (en) 2017-06-21
WO2016025829A1 (en) 2016-02-18
ES2750689T3 (es) 2020-03-26
US10683502B2 (en) 2020-06-16
JP6705807B2 (ja) 2020-06-03
JP2017529834A (ja) 2017-10-12

Similar Documents

Publication Publication Date Title
BR112017002629A2 (pt) decoys de oligonucleotídeo para o tratamento de dor
CL2017001204A1 (es) Derivados de 6-amino-7-biciclo-7-deaza-purina como inhibidores de la proteína quinasa
BR112017011923A2 (pt) bactéria modificada para tratar doenças associadas com hiperamonemia
CL2018001152A1 (es) Composiciones y métodos para el tratamiento del cáncer
BR112017024384A2 (pt) bactérias modificadas para reduzir hiperfenilalaninemia
EA201890725A1 (ru) Агонисты фарнезоидного х-рецептора и их применение
BR112017017727A8 (pt) Heterociclos bicíclicos como inibidores de fgfr4
BR112017002332A2 (pt) terapia de combinação para o tratamento de um paramixovírus
NI201600071A (es) Compuestos de inhibidor de autotaxina
BR112017006664A2 (pt) terapias de combinação
BR112017015864A2 (pt) compostos e métodos para modular a expressão de tmprss6
BR112016003201A2 (pt) inibidores de grp94 seletivos e usos dos mesmos
BR112017000301A2 (pt) tratamento de leucemia com inibidores de histona desacetilase
BR112016022855A2 (pt) composições e métodos para modular a expressão de pkk
GB2541571A (en) Pharmaceutical compositions
BR112015019995A2 (pt) Combinação terapêutica envolvendo anticorpos contra claudina 18.2 para tratamento de câncer
PH12016501441A1 (en) Chimeric alkaline phosphate-like proteins
EA201790802A1 (ru) Соединения против tnf
BR112017012504A2 (pt) derivados de piperidina como inibidores de hdac1/2
MX2015010791A (es) Metodos para tratar el cancer y prevenir la resistencia a farmacos.
NI201600070A (es) Inhibidores tetracíclicos de autotaxina
MX2017011277A (es) Inhibidores de glucosilceramida sintasa para el tratamiento de enfermedades.
BR112017000730B8 (pt) Derivados de pirrolidinona como inibidores de metap-2, e medicamentos
EA201790773A1 (ru) Композиции и способы для ингибирования биологической активности растворимых биомолекул
CL2018001085A1 (es) Derivados de indolin-2-ona

Legal Events

Date Code Title Description
B07D Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette]

Free format text: DE ACORDO COM O ARTIGO 229-C DA LEI NO 10196/2001, QUE MODIFICOU A LEI NO 9279/96, A CONCESSAO DA PATENTE ESTA CONDICIONADA A ANUENCIA PREVIA DA ANVISA. CONSIDERANDO A APROVACAO DOS TERMOS DO PARECER NO 337/PGF/EA/2010, BEM COMO A PORTARIA INTERMINISTERIAL NO 1065 DE 24/05/2012, ENCAMINHA-SE O PRESENTE PEDIDO PARA AS PROVIDENCIAS CABIVEIS.

B07E Notice of approval relating to section 229 industrial property law [chapter 7.5 patent gazette]
B06U Preliminary requirement: requests with searches performed by other patent offices: procedure suspended [chapter 6.21 patent gazette]
B11B Dismissal acc. art. 36, par 1 of ipl - no reply within 90 days to fullfil the necessary requirements
B350 Update of information on the portal [chapter 15.35 patent gazette]