BR112017000301A2 - tratamento de leucemia com inibidores de histona desacetilase - Google Patents

tratamento de leucemia com inibidores de histona desacetilase

Info

Publication number
BR112017000301A2
BR112017000301A2 BR112017000301A BR112017000301A BR112017000301A2 BR 112017000301 A2 BR112017000301 A2 BR 112017000301A2 BR 112017000301 A BR112017000301 A BR 112017000301A BR 112017000301 A BR112017000301 A BR 112017000301A BR 112017000301 A2 BR112017000301 A2 BR 112017000301A2
Authority
BR
Brazil
Prior art keywords
leukemia
individual
treatment
need
histone deacetylase
Prior art date
Application number
BR112017000301A
Other languages
English (en)
Inventor
Min Chengyin
Lee TAMANG David
Yang Min
S Jones Simon
Original Assignee
Acetylon Pharmaceuticals Inc
Lee TAMANG David
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Acetylon Pharmaceuticals Inc, Lee TAMANG David filed Critical Acetylon Pharmaceuticals Inc
Publication of BR112017000301A2 publication Critical patent/BR112017000301A2/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • A61K31/167—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the nitrogen of a carboxamide group directly attached to the aromatic ring, e.g. lidocaine, paracetamol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/404—Indoles, e.g. pindolol
    • A61K31/4045—Indole-alkylamines; Amides thereof, e.g. serotonin, melatonin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00

Abstract

são fornecidas aqui combinações compreendendo um inibidor de hdac e azacitidina para o tratamento de leucemia em um indivíduo em necessidade do mesmo. são fornecidas aqui combinações compreendendo um inibidor de hdac e azacitidina para o tratamento de leucemia mielogenosa aguda em um indivíduo em necessidade do mesmo. são também fonecidos métodos para tratamento de leucemia em um indivíduo em necessidade do mesmo, compreendendo administrar ao individuo uma quantidade eficaz da combinação acima ou um inibidor de hdac, bem como métodos para tratamento de leucemia mielogenosa aguda em um indivíduo em necessidade do mesmo, compreendendo administrar ao indivíduo uma quantidade eficaz da combinação acima ou um inibidor de hdac.
BR112017000301A 2014-07-07 2015-07-06 tratamento de leucemia com inibidores de histona desacetilase BR112017000301A2 (pt)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US201462021473P 2014-07-07 2014-07-07
US201462061233P 2014-10-08 2014-10-08
US201562147218P 2015-04-14 2015-04-14
PCT/US2015/039225 WO2016007423A1 (en) 2014-07-07 2015-07-06 Treatment of leukemia with histone deacetylase inhibitors

Publications (1)

Publication Number Publication Date
BR112017000301A2 true BR112017000301A2 (pt) 2017-11-07

Family

ID=55064739

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112017000301A BR112017000301A2 (pt) 2014-07-07 2015-07-06 tratamento de leucemia com inibidores de histona desacetilase

Country Status (13)

Country Link
US (1) US9833466B2 (pt)
EP (1) EP3166603B1 (pt)
JP (1) JP6952602B2 (pt)
KR (1) KR20170044097A (pt)
CN (1) CN107205988A (pt)
AU (1) AU2015288060A1 (pt)
BR (1) BR112017000301A2 (pt)
CA (1) CA2954522A1 (pt)
EA (1) EA201790142A1 (pt)
IL (1) IL249935A0 (pt)
MX (1) MX2017000307A (pt)
SG (1) SG11201700094TA (pt)
WO (1) WO2016007423A1 (pt)

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Also Published As

Publication number Publication date
AU2015288060A1 (en) 2017-02-09
EP3166603A1 (en) 2017-05-17
EP3166603A4 (en) 2017-12-13
JP2017524735A (ja) 2017-08-31
CN107205988A (zh) 2017-09-26
US20160030458A1 (en) 2016-02-04
MX2017000307A (es) 2017-11-23
IL249935A0 (en) 2017-03-30
SG11201700094TA (en) 2017-02-27
JP6952602B2 (ja) 2021-10-20
WO2016007423A1 (en) 2016-01-14
KR20170044097A (ko) 2017-04-24
US9833466B2 (en) 2017-12-05
EP3166603B1 (en) 2020-02-12
EA201790142A1 (ru) 2017-07-31
CA2954522A1 (en) 2016-01-14

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