BR112016013148A2 - "composições de rnai de componente do complemento e métodos de utilização das mesmas - Google Patents

"composições de rnai de componente do complemento e métodos de utilização das mesmas

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BR112016013148A2
BR112016013148A2 BR112016013148A BR112016013148A BR112016013148A2 BR 112016013148 A2 BR112016013148 A2 BR 112016013148A2 BR 112016013148 A BR112016013148 A BR 112016013148A BR 112016013148 A BR112016013148 A BR 112016013148A BR 112016013148 A2 BR112016013148 A2 BR 112016013148A2
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component
compositions
methods
complement
complement component
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BR112016013148A
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BR112016013148B1 (pt
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Borodovsky Anna
Bettencourt Brian
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Alnylam Pharmaceuticals Inc
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Publication of BR112016013148A2 publication Critical patent/BR112016013148A2/pt
Publication of BR112016013148B1 publication Critical patent/BR112016013148B1/pt

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Abstract

a invenção se relaciona com rnai, p.ex., ácido ribonucleico de fita dupla (dsrna), composições se dirigindo ao gene do fator b do complemento (cfb), ao gene do componente do complemento c3, e ao gene do componente do complemento c9 e métodos de uso de tal rnai, p.ex., dsrna, composições para inibir a expressão de cfb, c9 e/ou c3 e para tratar sujeitos tendo uma doença associada ao componente do complemento, p.ex., hemoglobinúria paroxística noturna e síndrome urêmica hemolítica atípica.
BR112016013148-7A 2013-12-12 2014-12-12 ÁCIDO RIBONUCLEICO DE FITA DUPLA (dsRNA) PARA INIBIÇÃO DA EXPRESSÃO DO FATOR B DO COMPLEMENTO (CFB) EM UMA CÉLULA, COMPOSIÇÃO FARMACÊUTICA PARA INIBIÇÃO DA EXPRESSÃO DE UM GENE DO FATOR B DO COMPLEMENTO, SEU USO, E MÉTODO IN VITRO DE INIBIÇÃO DA EXPRESSÃO DO FATOR B DO COMPLEMENTO (CFB) EM UMA CÉLULA BR112016013148B1 (pt)

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