ES2545360T3 - Métodos basados en microARN y composiciones para el diagnóstico y tratamiento de cánceres sólidos - Google Patents
Métodos basados en microARN y composiciones para el diagnóstico y tratamiento de cánceres sólidos Download PDFInfo
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- ES2545360T3 ES2545360T3 ES12154321.9T ES12154321T ES2545360T3 ES 2545360 T3 ES2545360 T3 ES 2545360T3 ES 12154321 T ES12154321 T ES 12154321T ES 2545360 T3 ES2545360 T3 ES 2545360T3
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Abstract
Un método para diagnosticar si un sujeto tiene cáncer de colon, de páncreas o de estómago, que comprende: medir el nivel de al menos un primer producto génico de miR-24-2 en una muestra de tejido de colon, de páncreas o de estómago del sujeto, en el que una alteración en el nivel del primer producto génico de miR-24-2 en la muestra, en relación con el nivel del primer producto génico de miR-24-2 en una muestra de control, es indicativa de que el sujeto tiene cáncer de colon, de páncreas o de próstata.
Description
E12154321
13-08-2015
alterada en células cancerosas asociadas con diferentes cánceres sólidos, tales como cáncer de colon, de estómago, pancreático, de pulmón, de mama y de próstata, en relación con células de control normales.
Como se usa en la presente memoria de forma intercambiable un “producto génico de miR”, “microARN”, “miR” o
5 “miARN” se refiere al transcrito de ARN no procesado (por ejemplo, precursor) o procesado (por ejemplo, maduro) de un gen de miR. Ya que los productos génicos de miR no se traducen a proteína, la expresión “productos génicos de miR” no incluye proteínas. El transcrito génico de miR no procesado también se denomina un “precursor de miR”
o “miR prec” y normalmente comprende un transcrito de ARN de aproximadamente 70-100 nucleótidos de longitud. El precursor de miR puede procesarse por digestión con una RNAsa (por ejemplo, Dicer, Argonaut o RNAsa III (por
10 ejemplo RNAsa III de E. coli)) en una molécula de ARN de 19-25 nucleótidos activa. Esta molécula de ARN de 19-25 nucleótidos activa también se denomina el transcrito génico de miR “procesado” o miARN “maduro”.
La molécula de ARN de 19-25 nucleótidos activa puede obtenerse del precursor de miR mediante vías de procesamiento naturales (por ejemplo, usando células intactas o lisados celulares) o mediante vías de
15 procesamiento sintéticas (por ejemplo, usando enzimas de procesamiento aisladas, tales como Dicer, Argonaut o RNAsa III aislada). Se entiende que la molécula de ARN de 19-25 nucleótidos activa también puede producirse directamente por síntesis biológica o química, sin haberse procesado a partir del precursor de miR. Cuando se hace referencia a un microARN en la presente memoria por nombre, el nombre corresponde a las formas tanto precursoras como maduras, a no ser que se indique de otro modo.
20 Las Tablas 1a y 1b representan las secuencias de nucleótidos de microARN humanos maduros y precursores particulares. Tabla 1a-Secuencias precursoras de microARN humano
- Nombre del Precursor
- Secuencia (5’ a 3’) SEC ID Nº
- let-7a-1
-
imagen6 1
- let-7a-2
- 2
- let-7a-3
- 3
- let-7a-4
- 4
- let-7b
- 5
- let-7c
- 6
- let-7d
- 7
- let-7d-v1
- 8
- let-7d-v2
- 9
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- let-7e
- 10
- let-7f-1
- 11
- let-7f-2-1
- 12
- let-7f-2-2
- 13
- let-7g
-
imagen7 14
- let-7i
-
imagen8 15
- miR-1b-1-1
- 16
- miR-1b-1-2
-
imagen9 17
- miR-1b-2
- 18
- miR-1b
- 19
- miR-1d
- 20
- miR-7-1a
- 21
- miR-7-1b
- 22
- miR-7-2
- 23
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- miR-7-3
- 24
- miR-9-1
- 25
- miR-9-2
- 26
- miR-9-3
- 27
- miR-10a
- 28
- miR-10b
-
imagen10 29
- miR-15a-2
-
imagen11 30
- miR-15a
- 31
- miR-15b-1
- 32
- miR-15b-2
-
imagen12 33
- miR-16-1
- 34
- miR-16-2
- 35
- miR-16-13
- 36
- miR-17
- 37
- miR-18
- 38
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- miR-18-13
- 39
- miR-19a
- 40
- miR-19a-13
- 41
- miR-19b-1
- 42
- miR-19b-2
-
imagen13 43
- miR-19b-13
- 44
- miR-19b-X
- 45
- miR-20 (miR20a)
- 46
- miR-21
- 47
- miR-21-17
- 48
- miR-22
- 49
- miR-23a
- 50
- miR-23b
- 51
- miR-23-19
- 52
- miR-24-1
- 53
- miR-24-2
- 54
- miR-24-19
- 55
- miR-24-9
- 56
- miR-25
- 57
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- miR-26a
- 58
- miR-26a-1
- 59
- miR-26a-2
-
imagen14 60
- miR-26b
- 61
- miR-27a
- 62
- miR-27b-1
- 63
- miR-27b-2
-
imagen15 64
- miR-27-19
- 65
- miR-28
- 66
- miR-29a-2
-
imagen16 67
- miR-29a
- 68
- miR-29b-1
- 69
- miR-29b-2
- 70
- miR-29c
- 71
- miR-30a
- 72
- miR-30b-1
- 73
- miR-30b-2
- 74
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- miR-30c
- 75
- miR-30d
-
imagen17 76
- miR-30e
- 77
- miR-31
-
imagen18 78
- miR-32
- 79
- miR-33b
- 80
- miR-33b-2
- 81
- miR-33
- 82
- miR-34-a
-
imagen19 83
- miR-34-b
- 84
- miR-34-c
- 85
- miR-91-13
- 86
- miR-92-1
- 87
- miR-92-2
- 88
- miR-93-1 (miR-93-2)
- 89
- miR-95-4
- 90
- miR-96-7
- 91
- miR-97-6 (miR-30*)
-
imagen20 92
- miR-98
- 93
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- miR-99b
- 94
- miR-99a
- 95
- miR-100-1/2
- 96
- miR-100-11
- 97
- miR-101-1/2
- 98
- miR-101
- 99
- miR-101-1
- 100
- miR-101-2
- 101
- miR-101-9
- 102
- miR-102-1
- 103
- miR-102-7.1 (miR-1027.2)
- 104
- miR-103-2
- 105
- miR-103-1
- 106
- miR-104-17
- 107
- miR-105-1
- 108
- miR-105-2
- 109
- miR-106-a
- 110
- miR-106-b
-
imagen21 111
- miR-107
-
imagen22 112
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- miR-108-1pequeño
- 113
- miR-108-2pequeño
- 114
- miR-122a-1
- 115
- miR-122a-2
- 116
- miR-123
- 117
- miR-124a-1
-
imagen23 118
- miR-124a-2
- 119
- miR-124a-3
- 120
- miR-124a
- 121
- miR-124b
- 122
- miR-125a-1
- 123
- miR-125a-2
- 124
- miR-125b-1
-
imagen24 125
- miR-125b-2
-
imagen25 126
- miR-126-1
-
imagen26 127
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- miR-126-2
- 128
- miR-127-1
-
imagen27 129
- miR-127-2
- 130
- miR-128a
- 131
- miR-128b
- 132
- miR-128
- 133
- miR-129-1
- 134
- miR-129-2
-
imagen28 135
- miR-130a
-
imagen29 136
- miR-131-1
-
imagen30 137
- miR-131-3
- 138
- miR-131
- 139
- miR-132-1
- 140
- miR-132-2
- 141
- miR-133a-1
- 142
- miR-133a-2
- 143
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- miR-133
- 144
- miR-133b
-
imagen31 145
- miR-133bpequeño
-
imagen32 146
- miR-134-1
- 147
- miR-134-2
-
imagen33 148
- miR-135a-1
- 149
- miR-13a-2 (miR-135-2)
- 150
- miR-135
- 151
- miR-135b
- 152
- miR-136-1
- 153
- miR-136-2
- 154
- miR-137
- 155
- miR-138-1
-
imagen34 156
- miR-138-2
-
imagen35 157
- miR-138
- 158
- miR-139
- 159
- miR-140
- 160
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- miR-140as
- 161
- miR-140s
- 162
- miR-141-1
- 163
- miR-141-2
- 164
- miR-142
- 165
- miR-143-1
- 166
- miR-143-2
- 167
- miR-144-1
- 168
- miR-144-2
- 169
- miR-145-1
-
imagen36 170
- miR-145-2
-
imagen37 171
- miR-146-1
- 172
- miR-146-2
-
imagen38 173
- miR-147
- 174
- miR-148a (miR-148)
- 175
- miR-148b
- 176
- miR-148bpequeño
- 177
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- miR-149-1
- 178
- miR-149-2
-
imagen39 179
- miR-150-1
-
imagen40 180
- miR-150-2
-
imagen41 181
- miR-151
- 182
- miR-151-2
-
imagen42 183
- miR-152-1
- 184
- miR-152-2
- 185
- miR-153-1-1
- 186
- miR-153-1-2
- 187
- miR-153-2-1
- 188
- miR-153-2-2
- 189
- miR-154-1
- 190
- miR-154-2
- 191
- miR-155
- 192
- miR-156 = miR-157 = solapamiento con miR-141
- 193
- miR-158pequeño = miR-192
- 194
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- miR-159-1pequeño
- 195
- miR-161pequeño
- 196
- miR-163-1bpequeño
- 197
- miR-163-3pequeño
-
imagen43 198
- miR-162
-
imagen44 199
- miR-175pequeño = miR-224
-
imagen45 200
- miR-177pequeño
-
imagen46 201
- miR-180pequeño
- 202
- miR-181a
- 203
- miR-181b-1
- 204
- miR-181b-2
-
imagen47 205
- miR-181c
-
imagen48 206
- miR-182-as
- 207
- miR-182
- 208
- miR-183
-
imagen49 209
- miR-184-1
- 210
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- miR-184-2
- 211
- miR-185-1
- 212
- miR-185-2
- 213
- miR-186-1
- 214
- miR-186-2
-
imagen50 215
- miR-187
-
imagen51 216
- miR-188-1
- 217
- miR-188-2
- 218
- miR-189-1
- 219
- miR-189-2
- 220
- miR-190-1
-
imagen52 221
- miR-190-2
- 222
- miR-191-1
- 223
- miR-191-2
- 224
- miR-192-2/3
- 225
- miR-192
- 226
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- miR-193-1
- 227
- miR-193-2
- 228
- miR-194-1
- 229
- miR-194-2
-
imagen53 230
- miR-195-1
- 231
- miR-195-2
- 232
- miR-196-1
-
imagen54 233
- miR-196a-1
- 234
- miR-196a-2 (miR-196-2)
- 235
- miR-196
- 236
- miR-196b
- 237
- miR-197
- 238
- miR-197-2
-
imagen55 239
- miR-198
- 240
- miR-199a-1
- 241
- miR-199a-2
- 242
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- miR-199b
- 243
- miR-199s
- 244
- miR-200a
- 245
- miR-200b
- 246
- miR-200c
- 247
- miR-202
- 248
- miR-203
- 249
- miR-204
-
imagen56 250
- miR-205
- 251
- miR-206-1
- 252
- miR-206-2
- 253
- miR-208
- 254
- miR-210
- 255
- miR-211
- 256
- miR-212
-
imagen57 257
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- miR-213-2
- 258
- miR-213
- 259
- miR-214
- 260
- miR-215
- 261
- miR-216
-
imagen58 262
- miR-217
-
imagen59 263
- miR-218-1
-
imagen60 264
- miR-218-2
-
imagen61 265
- miR-219
- 266
- miR-219-1
-
imagen62 267
- miR-219-2
- 268
- miR-220
-
imagen63 269
- miR-221
- 270
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- miR-222
- 271
- miR-223
-
imagen64 272
- miR-224
- 273
- miR-294-1 (chr16)
- 274
- miR-296
- 275
- miR-299
- 276
- miR-301
- 277
- miR-302a
- 278
- miR-302b
- 279
- miR-302c
- 280
- miR-302d
- 281
- miR-320
- 282
- miR-321
- 283
- miR-323
-
imagen65 284
- miR-324
-
imagen66 285
- miR-325
- 286
- miR-326
- 287
- miR-328
- 288
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- miR-330
- 289
- miR-331
- 290
- miR-335
-
imagen67 291
- miR-337
- 292
- miR-338
- 293
- miR-339
-
imagen68 294
- miR-340
- 295
- miR-342
- 296
- miR-345
-
imagen69 297
- miR-346
-
imagen70 298
- miR-367
-
imagen71 299
- miR-368
- 300
- miR-369
- 301
- miR-370
- 302
- miR-371
- 303
- miR-372
- 304
13-08-2015
- miR-373
- 305
- miR-374
-
imagen72 306
- miR-hes1
- 307
- miR-hes2
-
imagen73 308
- miR-hes3
-
imagen74 309
- * Una secuencia subrayada dentro de una secuencia precursora corresponde a un transcrito de miR procesado maduro (véase Tabla 1b). Algunas secuencias precursoras tienen dos secuencias subrayadas que indican dos miR maduros diferentes que derivan del mismo precursor. Todas las secuencias son humanas.
Tabla 1b-Secuencias de microARN maduro humano.
- Nombre de miARN Maduro
- Secuencia de miARN Maduro (5’ a 3’) SEC ID Nº microARN precursor correspondiente; véase Tabla 1a
- let-7a
- ugagguaguagguuguauaguu 310 let-7a-1; let-7a-2; let-7a-3; let-7a-4
- let-7b
- ugagguaguagguugugugguu 311
- let-7b
- let-7c
- ugagguaguagguuguaugguu 312
- let-7c
- let-7d
- agagguaguagguugcauagu 313 let-7d; let-7d-v1
- let-7e
- ugagguaggagguuguauagu 314
- let-7e
- let-7f
- ugagguaguagauuguauaguu 315 let-7f-1; let-7f-2-1; let-7f-2-2
- let-7g
- ugagguaguaguuuguacagu 316
- let-7g
- let-7i
- ugagguaguaguuugugcu 317
- let-7i
- miR-1
- uggaauguaaagaaguaugua 318 miR-1b; miR-1b-1; miR-1b-2
- miR-7
- uggaagacuagugauuuuguu 319 miR-7-1; miR-7-1a; miR-7-2; miR-7-3
- miR-9
- ucuuugguuaucuagcuguauga 320 miR-9-1; miR-9-2; miR-9-3
- miR-9*
- uaaagcuagauaaccgaaagu 321 miR-9-1; miR-9-2; miR-9-3
- miR-10a
- uacccuguagauccgaauuugug 322
- miR-10a
- miR-10b
- uacccuguagaaccgaauuugu 323
- miR-10b
- miR-15a
- uagcagcacauaaugguuugug 324 miR-15a; miR-15a-2
- miR-15b
- uagcagcacaucaugguuuaca 325
- miR-15b
- miR-16
- uagcagcacguaaauauuggcg 326 miR-16-1; miR-16-2; miR-16-13
- miR-17-5p
- caaagugcuuacagugcagguagu 327 miR-17
- miR-17-3p
- acugcagugaaggcacuugu 328 miR-17
- miR-18
- uaaggugcaucuagugcagaua 329 miR-18; miR-18-13
- miR-19a
- ugugcaaaucuaugcaaaacuga 330 miR-19a; miR-19a-13
- miR-19b
- ugugcaaauccaugcaaaacuga 331 miR-19b-1; miR-19b-2
- miR-20
- uaaagugcuuauagugcaggua 332 miR-20 (miR-20a)
- miR-21
- uagcuuaucagacugauguuga 333 miR-21; miR-21-17
- miR-22
- aagcugccaguugaagaacugu 334
- miR-22
- miR-23a
- aucacauugccagggauuucc 335
- miR-23a
- miR-23b
- aucacauugccagggauuaccac 336
- miR-23b
- miR-24
- uggcucaguucagcaggaacag 337 miR-24-1; miR-24-2; miR-24-19; miR24-9
- miR-25
- cauugcacuugucucggucuga 338
- miR-25
- miR-26a
- uucaaguaauccaggauaggcu 339 miR-26a; miR-26a-1; miR-26a-2
- miR-26b
- uucaaguaauucaggauaggu 340
- miR-26b
- miR-27a
- uucacaguggcuaaguuccgcc 341
- miR-27a
- miR-27b
- uucacaguggcuaaguucug 342 miR-27b-1; miR-27b-2
E12154321
13-08-2015 E12154321
- miR-28
- aaggagcucacagucuauugag 343
- miR-28
- miR-29a
- cuagcaccaucugaaaucgguu 344 miR-29a-2; miR-29a
- miR-29b
- uagcaccauuugaaaucagu 345 miR-29b-1; miR-29b-2
- miR-29c
- uagcaccauuugaaaucgguua 346
- miR-29c
- miR-30a-5p
- uguaaacauccucgacuggaagc 347 miR-30a
- miR-30a-3p
- cuuucagucggauguuugcagc 348 miR-30a
- miR-30b
- uguaaacauccuacacucagc 349 miR-30b-1; miR-30b-2
- miR-30c
- uguaaacauccuacacucucagc 350
- miR-30c
- miR-30d
- uguaaacauccccgacuggaag 351
- miR-30d
- miR-30e
- uguaaacauccuugacugga 352
- miR-30e
- miR-31
- ggcaagaugcuggcauagcug 353
- miR-31
- miR-32
- uauugcacauuacuaaguugc 354
- miR-32
- miR-33
- gugcauuguaguugcauug 355 miR-33; miR-33b
- miR-34a
- uggcagugucuuagcugguugu 356
- miR-34a
- miR-34b
- aggcagugucauuagcugauug 357
- miR-34b
- miR-34c
- aggcaguguaguuagcugauug 358
- miR-34c
- miR-92
- uauugcacuugucccggccugu 359 miR-92-2; miR-92-1
- miR-93
- aaagugcuguucgugcagguag 360 miR-93-1; miR-93-2
- miR-95
- uucaacggguauuuauugagca 361
- miR-95
- miR-96
- uuuggcacuagcacauuuuugc 362
- miR-96
- miR-98
- ugagguaguaaguuguauuguu 363
- miR-98
- miR-99a
- aacccguagauccgaucuugug 364
- miR-99a
- miR-99b
- cacccguagaaccgaccuugcg 365
- miR-99b
- miR-100
- uacaguacugugauaacugaag 366
- miR-100
- miR-101
- uacaguacugugauaacugaag 367 miR-101-1; miR-101-2
- miR-103
- agcagcauuguacagggcuauga 368 miR-103-1
- miR-105
- ucaaaugcucagacuccugu 369
- miR-105
- miR-106-a
- aaaagugcuuacagugcagguagc 370
- miR-106-a
- miR-106-b
- uaaagugcugacagugcagau 371
- miR-106-b
- miR-107
- agcagcauuguacagggcuauca 372
- miR-107
- miR-122a
- uggagugugacaaugguguuugu 373 miR-122a-1; miR-122a-2
- miR-124a
- uuaaggcacgcggugaaugcca 374 miR-124a-1; miR-124a-2; miR-124a-3
- miR-125a
- ucccugagacccuuuaaccugug 375 miR-125a-1; miR-125a-2
- miR-125b
- ucccugagacccuaacuuguga 376 miR-125b-1; miR-125b-2
- miR-126*
- cauuauuacuuuugguacgcg 377 miR-126-1; miR-126-2
- miR-126
- ucguaccgugaguaauaaugc 378 miR-126-1; miR-126-2
- miR-127
- ucggauccgucugagcuuggcu 379 miR-127-1; miR-127-2
- miR-128a
- ucacagugaaccggucucuuuu 380 miR-128; miR-128a
- miR-128b
- ucacagugaaccggucucuuuc 381
- miR-128b
- miR-129
- cuuuuugcggucugggcuugc 382 miR-129-1; miR-129-2
- miR-130a
- cagugcaauguuaaaagggc 383
- miR-130a
- miR-130b
- cagugcaaugaugaaagggcau 384
- miR-130b
- miR-132
- uaacagucuacagccauggucg 385 miR-132-1
- miR-133a
- uugguccccuucaaccagcugu 386 miR-133a-1; miR-133a-2
- miR-133b
- uugguccccuucaaccagcua 387
- miR-133b
- miR-134
- ugugacugguugaccagaggg 388 miR-134-1; miR-134-2
- miR-135a
- uauggcuuuuuauuccuauguga 389 miR-135a; miR-135a-2 (miR-135-2)
- miR-135b
- uauggcuuuucauuccuaugug 390
- miR-135b
- miR-136
- acuccauuuguuuugaugaugga 391 miR-136-1; miR-136-2
- miR-137
- uauugcuuaagaauacgcguag 392
- miR-137
- miR-138
- agcugguguugugaauc 393 miR-138-1; miR-138-2
- miR-139
- ucuacagugcacgugucu 394
- miR-139
- miR-140
- agugguuuuacccuaugguag 395 miR-140; miR-140as; miR-140s
- miR-141
- aacacugucugguaaagaugg 396 miR-141-1; miR-141-2
- miR-142-3p
- uguaguguuuccuacuuuaugga 397 miR-142
- miR-142-5p
- cauaaaguagaaagcacuac 398 miR-142
- miR-143
- ugagaugaagcacuguagcuca 399 miR-143-1
- miR-144
- uacaguauagaugauguacuag 400 miR-144-1; miR-144-2
- miR-145
- guccaguuuucccaggaaucccuu 401 miR-145-1; miR-145-2
- miR-146
- ugagaacugaauuccauggguu 402 miR-146-1; miR-146-2
- miR-147
- guguguggaaaugcuucugc 403
- miR-147
13-08-2015 E12154321
- miR-148a
- ucagugcacuacagaacuuugu 404 miR-148a (miR-148)
- miR-148b
- ucagugcaucacagaacuuugu 405
- miR-148b
- miR-149
- ucuggcuccgugucuucacucc 406
- miR-149
- miR-150
- ucucccaacccuuguaccagug 407 miR-150-1; miR-150-2
- miR-151
- acuagacugaagcuccuugagg 408
- miR-151
- miR-152
- ucagugcaugacagaacuugg 409 miR-152-1; miR-152-2
- miR-153
- uugcauagucacaaaaguga 410 miR-153-1-1; miR-153-1-2; miR-153-21; miR-153-2-2
- miR-154
- uagguuauccguguugccuucg 411 miR-154-1; miR-154-2
- miR-154*
- aaucauacacgguugaccuauu 412 miR-154-1; miR-154-2
- miR-155
- uuaaugcuaaucgugauagggg 413
- miR-155
- miR-181a
- aacauucaacgcugucggugagu 414
- miR-181a
- miR-181b
- aacauucauugcugucgguggguu 415 miR-181b-1; miR-181b-2
- miR-181c
- aacauucaaccugucggugagu 416
- miR-181c
- miR-182
- uuuggcaaugguagaacucaca 417 miR-182; miR-182as
- miR-182*
- ugguucuagacuugccaacua 418 miR-182; miR-182as
- miR-183
- uauggcacugguagaauucacug 419
- miR-183
- miR-184
- uggacggagaacugauaagggu 420 miR-184-1; miR-184-2
- miR-185
- uggagagaaaggcaguuc 421 miR-185-1; miR-185-2
- miR-186
- caaagaauucuccuuuugggcuu 422 miR-186-1; miR-186-2
- miR-187
- ucgugucuuguguugcagccg 423
- miR-187
- miR-188
- caucccuugcaugguggagggu 424
- miR-188
- miR-189
- gugccuacugagcugauaucagu 425 miR-189-1; miR-189-2
- miR-190
- ugauauguuugauauauuaggu 426 miR-190-1; miR-190-2
- miR-191
- caacggaaucccaaaagcagcu 427 miR-191-1; miR-191-2
- miR-192
- cugaccuaugaauugacagcc 428
- miR-192
- miR-193
- aacuggccuacaaagucccag 429 miR-193-1; miR-193-2
- miR-194
- uguaacagcaacuccaugugga 430 miR-194-1; miR-194-2
- miR-195
- uagcagcacagaaauauuggc 431 miR-195-1; miR-195-2
- miR-196a
- uagguaguuucauguuguugg 432 miR-196a; miR-196a-2 (miR196-2)
- miR-196b
- uagguaguuuccuguugg 433
- miR-196b
- miR-197
- uucaccaccuucuccacccagc 434
- miR-197
- miR-198
- gguccagaggggagauagg 435
- miR-198
- miR-199a
- cccaguguucagacuaccuguuc 436 miR-199a-1; miR-199a-2
- miR-199a*
- uacaguagucugcacauugguu 437 miR-199a-1; miR-199a-2; miR-199s; miR-199b
- miR-199b
- cccaguguuuagacuaucuguuc 438
- miR-199b
- miR-200a
- uaacacugucugguaacgaugu 439
- miR-200a
- miR-200b
- cucuaauacugccugguaaugaug 440
- miR-200b
- miR-200c
- aauacugccggguaaugaugga 441
- miR-200c
- miR-202
- agagguauagggcaugggaaga 442
- miR-202
- miR-203
- gugaaauguuuaggaccacuag 443
- miR-203
- miR-204
- uucccuuugucauccuaugccu 444
- miR-204
- miR-205
- uccuucauuccaccggagucug 445
- miR-205
- miR-206
- uggaauguaaggaagugugugg 446 miR-206-1; miR-206-2
- miR-208
- auaagacgagcaaaaagcuugu 447
- miR-208
- miR-210
- cugugcgugugacagcggcug 448
- miR-210
- miR-211
- uucccuuugucauccuucgccu 449
- miR-211
- miR-212
- uaacagucuccagucacggcc 450
- miR-212
- miR-213
- accaucgaccguugauuguacc 451
- miR-213
- miR-214
- acagcaggcacagacaggcag 452
- miR-214
- miR-215
- augaccuaugaauugacagac 453
- miR-215
- miR-216
- uaaucucagcuggcaacugug 454
- miR-216
- miR-217
- uacugcaucaggaacugauuggau 455
- miR-217
- miR-218
- uugugcuugaucuaaccaugu 456 miR-218-1; miR-278-2
- miR-219
- ugauuguccaaacgcaauucu 457 miR-219; miR-219-1; miR-219-2
- miR-220
- ccacaccguaucugacacuuu 458
- miR-220
- miR-221
- agcuacauugucugcuggguuuc 459
- miR-221
- miR-222
- agcuacaucuggcuacugggucuc 460
- miR-222
- miR-223
- ugucaguuugucaaauacccc 461
- miR-223
- miR-224
- caagucacuagugguuccguuua 462
- miR-224
13-08-2015
- miR-296
- agggcccccccucaauccugu 463
- miR-296
- miR-299
- ugguuuaccgucccacauacau 464
- miR-299
- miR-301
- cagugcaauaguauugucaaagc 465
- miR-301
- miR-302a
- uaagugcuuccauguuuugguga 466
- miR-302a
- miR-302b*
- acuuuaacauggaagugcuuucu 467 miR-302b
- miR-302b
- uaagugcuuccauguuuuaguag 468
- miR-302b
- miR-302c*
- uuuaacauggggguaccugcug 469 miR-302c
- miR-302c
- uaagugcuuccauguuucagugg 470
- miR-302c
- miR-302d
- uaagugcuuccauguuugagugu 471
- miR-302d
- miR-320
- aaaagcuggguugagagggcgaa 472
- miR-320
- miR-321
- uaagccagggauuguggguuc 473
- miR-321
- miR-323
- gcacauuacacggucgaccucu 474
- miR-323
- miR-324-5p
- cgcauccccuagggcauuggugu 475 miR-324
- miR-324-3p
- ccacugccccaggugcugcugg 476 miR-324
- miR-325
- ccuaguagguguccaguaagu 477
- miR-325
- miR-326
- ccucugggcccuuccuccag 478
- miR-326
- miR-328
- cuggcccucucugcccuuccgu 479
- miR-328
- miR-330
- gcaaagcacacggccugcagaga 480
- miR-330
- miR-331
- gccccugggccuauccuagaa 481
- miR-331
- miR-335
- ucaagagcaauaacgaaaaaugu 482
- miR-335
- miR-337
- uccagcuccuauaugaugccuuu 483
- miR-337
- miR-338
- uccagcaucagugauuuuguuga 484
- miR-338
- miR-339
- ucccuguccuccaggagcuca 485
- miR-339
- miR-340
- uccgucucaguuacuuuauagcc 486
- miR-340
- miR-342
- ucucacacagaaaucgcacccguc 487
- miR-342
- miR-345
- ugcugacuccuaguccagggc 488
- miR-345
- miR-346
- ugucugcccgcaugccugccucu 489
- miR-346
- miR-367
- aauugcacuuuagcaaugguga 490
- miR-367
- miR-368
- acauagaggaaauuccacguuu 491
- miR-368
- miR-369
- aauaauacaugguugaucuuu 492
- miR-369
- miR-370
- gccugcugggguggaaccugg 493
- miR-370
- miR-371
- gugccgccaucuuuugagugu 494
- miR-371
- miR-372
- aaagugcugcgacauuugagcgu 495
- miR-372
- miR-373*
- acucaaaaugggggcgcuuucc 496 miR-373
- miR-373
- gaagugcuucgauuuuggggugu 497
- miR-373
- miR-374
- uuauaauacaaccugauaagug 498
- miR-374
La presente invención abarca métodos para diagnosticar si un sujeto tiene un cáncer sólido, que comprenden medir el nivel de al menos un primer producto génico de miR-24-2 en una muestra de ensayo del sujeto y comparar el nivel del producto génico de miR en la muestra de ensayo con el nivel del producto génico de miR correspondiente en una
5 muestra de control. Como se usa en la presente memoria un “sujeto” puede ser cualquier mamífero que tenga, o se sospeche que tiene, un cáncer sólido. En una realización preferida, el sujeto es un ser humano que tiene, o se sospecha que tiene, un cáncer sólido.
También se desvelan en la presente memoria métodos en los que el al menos un producto génico de miR medido en
10 la muestra de ensayo se selecciona del grupo que consiste en miR-21, miR-17-5p, miR-191, miR-29b-2, miR-223, miR-128b, miR-199a-1, miR-24-1, miR-24-2, miR-146, miR-155, miR-181b-1, miR-20a, miR-107, miR-32, miR-92-2, miR-214, miR-30c, miR-25, miR-221, miR-106a y combinaciones de los mismos. También se desvelan en la presente memoria métodos en los que el producto génico de miR es miR-21, miR-191 o miR-17-5p. También se desvelan en la presente memoria métodos en los que el producto génico de miR no es miR-15a o miR-16-1.
15 También se desvelan en la presente memoria métodos en los que el producto génico de miR no es miR 159-1 o miR-192. También se desvelan en la presente memoria métodos en los que el producto génico de miR no es miR186, miR-101-1, miR-194, miR-215, miR-106b, miR-25, miR-93, miR-29b, miR-29a, miR-96, miR-182s, miR-182as, miR-183, miR-129-1, let-7a-1, let-7d, let-7f-1, miR-23b, miR-24-1, miR-27b, miR-32, miR-159-1, miR-192, miR-125b1, let-7a-2, miR-100, miR-196-2, miR-148b, miR-190, miR-21, miR-301, miR-142s, miR-142as, miR-105-1 o miR
20 175. También se desvelan en la presente memoria métodos en los que el producto génico de miR no es miR-21, miR-301, miR-142as, miR-142s, miR-194, miR-215 o miR-32. También se desvelan en la presente memoria métodos en los que el producto génico de miR no es miR-148, miR-10a, miR-196-1, miR-152, miR-196-2, miR-148b, miR-10b, miR-129-1, miR-153-2, miR-202, miR-139, let-7a, let-7f o let-7d. También se desvelan en la presente memoria métodos en los que el producto génico de miR no es miR-15a, miR-16-1, miR-182, miR-181, miR-30, miR-15a, miR
25 16-1, miR-15b, miR-16-2, miR-195, miR-34, miR-153, miR-21, miR-217, miR-205, miR-204, miR-211, miR-143, miR96, miR-103, miR-107, miR-129, miR-9, miR-137, miR-217, miR-186.
Claims (1)
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ES12154342.5T Active ES2557411T3 (es) | 2006-01-05 | 2007-01-03 | Métodos y composiciones basados en microARN para el diagnóstico y el tratamiento de cánceres sólidos |
ES12154348.2T Active ES2536422T3 (es) | 2006-01-05 | 2007-01-03 | Métodos y composiciones basados en microARN para el diagnóstico y tratamiento de cáncer pancreático |
ES12154345T Active ES2461189T3 (es) | 2006-01-05 | 2007-01-03 | Métodos basados en microARN y composiciones para el diagnóstico y el tratamiento de cánceres sólidos de mama o pulmón |
ES12154344T Active ES2465600T3 (es) | 2006-01-05 | 2007-01-03 | Métodos basados en microARN y composiciones para el diagnóstico y tratamiento de cánceres sólidos del páncreas |
ES07717903.4T Active ES2508893T3 (es) | 2006-01-05 | 2007-01-03 | Métodos basados en microARN para el diagnóstico de cánceres de estómago |
ES12154315.1T Active ES2527592T3 (es) | 2006-01-05 | 2007-01-03 | Métodos basados en microARN para el diagnóstico del cáncer de colon |
ES12154334.2T Active ES2545118T3 (es) | 2006-01-05 | 2007-01-03 | Métodos basados en microARN y composiciones para el diagnóstico y tratamiento de cánceres sólidos |
ES12154337.5T Active ES2546425T3 (es) | 2006-01-05 | 2007-01-03 | Métodos basados en microARN y composiciones para el diagnóstico y el tratamiento de cánceres sólidos |
ES12154350.8T Active ES2525584T3 (es) | 2006-01-05 | 2007-01-03 | Métodos basados en microARN y composiciones para el diagnóstico y el tratamiento de cánceres sólidos |
ES12154321.9T Active ES2545360T3 (es) | 2006-01-05 | 2007-01-03 | Métodos basados en microARN y composiciones para el diagnóstico y tratamiento de cánceres sólidos |
ES12154304.5T Active ES2490995T3 (es) | 2006-01-05 | 2007-01-03 | Métodos basados en microARN y composiciones para el diagnóstico y el tratamiento de cánceres sólidos |
ES12154353.2T Active ES2536423T3 (es) | 2006-01-05 | 2007-01-03 | Métodos basados en microARN para el diagnóstico de cáncer de próstata |
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2009
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