ES2531052T3 - Métodos y composiciones basados en microARN para el diagnóstico de cánceres de mama - Google Patents

Métodos y composiciones basados en microARN para el diagnóstico de cánceres de mama Download PDF

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ES2531052T3
ES2531052T3 ES12154349T ES12154349T ES2531052T3 ES 2531052 T3 ES2531052 T3 ES 2531052T3 ES 12154349 T ES12154349 T ES 12154349T ES 12154349 T ES12154349 T ES 12154349T ES 2531052 T3 ES2531052 T3 ES 2531052T3
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mir
microrna
diagnosis
methods
compositions based
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Carlo Croce
George Calin
Stefano Volinia
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Ohio State University Research Foundation
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    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A61K31/7105—Natural ribonucleic acids, i.e. containing only riboses attached to adenine, guanine, cytosine or uracil and having 3'-5' phosphodiester links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • C12N15/09—Recombinant DNA-technology
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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
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    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/10—Type of nucleic acid
    • C12N2310/11—Antisense
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    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/10—Type of nucleic acid
    • C12N2310/14—Type of nucleic acid interfering N.A.
    • C12N2310/141—MicroRNAs, miRNAs
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    • C12N2320/00—Applications; Uses
    • C12N2320/10—Applications; Uses in screening processes
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    • C12N2320/12—Applications; Uses in screening processes in functional genomics, i.e. for the determination of gene function
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    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813—Hybridisation assays
    • C12Q1/6834—Enzymatic or biochemical coupling of nucleic acids to a solid phase
    • C12Q1/6837—Enzymatic or biochemical coupling of nucleic acids to a solid phase using probe arrays or probe chips
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    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/158—Expression markers
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    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/178—Oligonucleotides characterized by their use miRNA, siRNA or ncRNA

Abstract

Un método para diagnosticar si un sujeto tiene cáncer de mama, que comprende: medir los niveles de un grupo de productos génicos de miR que consisten en miR-125b-2, miR-5 125b-1, miR-10b, miR-181a, miR-140, miR-213, miR-29a prec, miR-199b, miR-29b-1, miR-130a, miR-155, let-7a-2, miR-29c, miR- 224, miR-31, miR-122a, miR-16-2, miR-21, miR-145, miR-205, miR-100, miR-30c, miR-17-5p, miR-210, miR-29b- 2, miR-146 y miR-181b-1 en una muestra de ensayo del sujeto; en el que una alteración en los niveles del grupo de productos génicos de miR en la muestra de ensayo, en relación a los niveles de los correspondientes productos génicos de miR en una muestra de control, es indicativo de que el sujeto tiene cáncer de mama, y en el que la muestra de ensayo es tejido mamario.
ES12154349T 2006-01-05 2007-01-03 Métodos y composiciones basados en microARN para el diagnóstico de cánceres de mama Active ES2531052T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US75658506P 2006-01-05 2006-01-05

Publications (1)

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ES2531052T3 true ES2531052T3 (es) 2015-03-10

Family

ID=38256892

Family Applications (22)

Application Number Title Priority Date Filing Date
ES12154342.5T Active ES2557411T3 (es) 2006-01-05 2007-01-03 Métodos y composiciones basados en microARN para el diagnóstico y el tratamiento de cánceres sólidos
ES12154348.2T Active ES2536422T3 (es) 2006-01-05 2007-01-03 Métodos y composiciones basados en microARN para el diagnóstico y tratamiento de cáncer pancreático
ES12154345T Active ES2461189T3 (es) 2006-01-05 2007-01-03 Métodos basados en microARN y composiciones para el diagnóstico y el tratamiento de cánceres sólidos de mama o pulmón
ES12154344T Active ES2465600T3 (es) 2006-01-05 2007-01-03 Métodos basados en microARN y composiciones para el diagnóstico y tratamiento de cánceres sólidos del páncreas
ES07717903.4T Active ES2508893T3 (es) 2006-01-05 2007-01-03 Métodos basados en microARN para el diagnóstico de cánceres de estómago
ES12154315.1T Active ES2527592T3 (es) 2006-01-05 2007-01-03 Métodos basados en microARN para el diagnóstico del cáncer de colon
ES12154334.2T Active ES2545118T3 (es) 2006-01-05 2007-01-03 Métodos basados en microARN y composiciones para el diagnóstico y tratamiento de cánceres sólidos
ES12154337.5T Active ES2546425T3 (es) 2006-01-05 2007-01-03 Métodos basados en microARN y composiciones para el diagnóstico y el tratamiento de cánceres sólidos
ES12154350.8T Active ES2525584T3 (es) 2006-01-05 2007-01-03 Métodos basados en microARN y composiciones para el diagnóstico y el tratamiento de cánceres sólidos
ES12154321.9T Active ES2545360T3 (es) 2006-01-05 2007-01-03 Métodos basados en microARN y composiciones para el diagnóstico y tratamiento de cánceres sólidos
ES12154304.5T Active ES2490995T3 (es) 2006-01-05 2007-01-03 Métodos basados en microARN y composiciones para el diagnóstico y el tratamiento de cánceres sólidos
ES12154353.2T Active ES2536423T3 (es) 2006-01-05 2007-01-03 Métodos basados en microARN para el diagnóstico de cáncer de próstata
ES12154341T Active ES2530843T3 (es) 2006-01-05 2007-01-03 Métodos basados en microARN para el diagnóstico de cáncer de páncreas
ES12154346.6T Active ES2537880T3 (es) 2006-01-05 2007-01-03 Métodos basados en microARN para el diagnóstico de cáncer de próstata o cánceres de estómago
ES12154354.0T Active ES2536437T3 (es) 2006-01-05 2007-01-03 Métodos basados en microARN para el diagnóstico de cáncer de estómago
ES12154307T Active ES2440787T3 (es) 2006-01-05 2007-01-03 Métodos basados en microARN y composiciones para el diagnóstico y el tratamiento de cánceres sólidos
ES12154343.3T Active ES2604324T3 (es) 2006-01-05 2007-01-03 Métodos y composiciones basadas en microARN para el diagnóstico y el tratamiento de cánceres sólidos
ES12154322.7T Active ES2547805T3 (es) 2006-01-05 2007-01-03 Métodos basados en microARN y composiciones para el diagnóstico y el tratamiento de cánceres sólidos
ES12154327.6T Active ES2544713T3 (es) 2006-01-05 2007-01-03 Métodos basados en microARN y composiciones para el diagnóstico y tratamiento de cánceres sólidos
ES12154349T Active ES2531052T3 (es) 2006-01-05 2007-01-03 Métodos y composiciones basados en microARN para el diagnóstico de cánceres de mama
ES12154339.1T Active ES2545119T3 (es) 2006-01-05 2007-01-03 Métodos basados en microARN y composiciones para el diagnóstico y el tratamiento de cánceres sólidos
ES12154332.6T Active ES2526787T3 (es) 2006-01-05 2007-01-03 Métodos basados en microARN para el diagnóstico de cánceres de colon, páncreas y estómago

Family Applications Before (19)

Application Number Title Priority Date Filing Date
ES12154342.5T Active ES2557411T3 (es) 2006-01-05 2007-01-03 Métodos y composiciones basados en microARN para el diagnóstico y el tratamiento de cánceres sólidos
ES12154348.2T Active ES2536422T3 (es) 2006-01-05 2007-01-03 Métodos y composiciones basados en microARN para el diagnóstico y tratamiento de cáncer pancreático
ES12154345T Active ES2461189T3 (es) 2006-01-05 2007-01-03 Métodos basados en microARN y composiciones para el diagnóstico y el tratamiento de cánceres sólidos de mama o pulmón
ES12154344T Active ES2465600T3 (es) 2006-01-05 2007-01-03 Métodos basados en microARN y composiciones para el diagnóstico y tratamiento de cánceres sólidos del páncreas
ES07717903.4T Active ES2508893T3 (es) 2006-01-05 2007-01-03 Métodos basados en microARN para el diagnóstico de cánceres de estómago
ES12154315.1T Active ES2527592T3 (es) 2006-01-05 2007-01-03 Métodos basados en microARN para el diagnóstico del cáncer de colon
ES12154334.2T Active ES2545118T3 (es) 2006-01-05 2007-01-03 Métodos basados en microARN y composiciones para el diagnóstico y tratamiento de cánceres sólidos
ES12154337.5T Active ES2546425T3 (es) 2006-01-05 2007-01-03 Métodos basados en microARN y composiciones para el diagnóstico y el tratamiento de cánceres sólidos
ES12154350.8T Active ES2525584T3 (es) 2006-01-05 2007-01-03 Métodos basados en microARN y composiciones para el diagnóstico y el tratamiento de cánceres sólidos
ES12154321.9T Active ES2545360T3 (es) 2006-01-05 2007-01-03 Métodos basados en microARN y composiciones para el diagnóstico y tratamiento de cánceres sólidos
ES12154304.5T Active ES2490995T3 (es) 2006-01-05 2007-01-03 Métodos basados en microARN y composiciones para el diagnóstico y el tratamiento de cánceres sólidos
ES12154353.2T Active ES2536423T3 (es) 2006-01-05 2007-01-03 Métodos basados en microARN para el diagnóstico de cáncer de próstata
ES12154341T Active ES2530843T3 (es) 2006-01-05 2007-01-03 Métodos basados en microARN para el diagnóstico de cáncer de páncreas
ES12154346.6T Active ES2537880T3 (es) 2006-01-05 2007-01-03 Métodos basados en microARN para el diagnóstico de cáncer de próstata o cánceres de estómago
ES12154354.0T Active ES2536437T3 (es) 2006-01-05 2007-01-03 Métodos basados en microARN para el diagnóstico de cáncer de estómago
ES12154307T Active ES2440787T3 (es) 2006-01-05 2007-01-03 Métodos basados en microARN y composiciones para el diagnóstico y el tratamiento de cánceres sólidos
ES12154343.3T Active ES2604324T3 (es) 2006-01-05 2007-01-03 Métodos y composiciones basadas en microARN para el diagnóstico y el tratamiento de cánceres sólidos
ES12154322.7T Active ES2547805T3 (es) 2006-01-05 2007-01-03 Métodos basados en microARN y composiciones para el diagnóstico y el tratamiento de cánceres sólidos
ES12154327.6T Active ES2544713T3 (es) 2006-01-05 2007-01-03 Métodos basados en microARN y composiciones para el diagnóstico y tratamiento de cánceres sólidos

Family Applications After (2)

Application Number Title Priority Date Filing Date
ES12154339.1T Active ES2545119T3 (es) 2006-01-05 2007-01-03 Métodos basados en microARN y composiciones para el diagnóstico y el tratamiento de cánceres sólidos
ES12154332.6T Active ES2526787T3 (es) 2006-01-05 2007-01-03 Métodos basados en microARN para el diagnóstico de cánceres de colon, páncreas y estómago

Country Status (9)

Country Link
US (24) US8148069B2 (es)
EP (31) EP2471958A1 (es)
JP (4) JP5395439B2 (es)
CN (3) CN105907842A (es)
AU (1) AU2007205163B2 (es)
CA (1) CA2633754C (es)
ES (22) ES2557411T3 (es)
HK (1) HK1132302A1 (es)
WO (1) WO2007081740A2 (es)

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