ATE231187T1 - Methoden zur detektion von mikrometastasen bei prostata-krebs - Google Patents

Methoden zur detektion von mikrometastasen bei prostata-krebs

Info

Publication number
ATE231187T1
ATE231187T1 AT93925095T AT93925095T ATE231187T1 AT E231187 T1 ATE231187 T1 AT E231187T1 AT 93925095 T AT93925095 T AT 93925095T AT 93925095 T AT93925095 T AT 93925095T AT E231187 T1 ATE231187 T1 AT E231187T1
Authority
AT
Austria
Prior art keywords
prostate cancer
methods
rna
amplified
detecting micrometastases
Prior art date
Application number
AT93925095T
Other languages
English (en)
Inventor
Carlo Croce
Leonard Gomella
S Grant Mulholland
Jose G Moreno
Rainer Fischer
Original Assignee
Univ Jefferson
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Jefferson filed Critical Univ Jefferson
Application granted granted Critical
Publication of ATE231187T1 publication Critical patent/ATE231187T1/de

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C12Q1/6886Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00Oligonucleotides characterized by their use
    • C12Q2600/112Disease subtyping, staging or classification

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Pathology (AREA)
  • Analytical Chemistry (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Hospice & Palliative Care (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Oncology (AREA)
  • Biotechnology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
AT93925095T 1992-10-29 1993-10-27 Methoden zur detektion von mikrometastasen bei prostata-krebs ATE231187T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US97332292A 1992-10-29 1992-10-29
PCT/US1993/010331 WO1994010343A1 (en) 1992-10-29 1993-10-27 Methods of detecting micrometastasis of prostate cancer

Publications (1)

Publication Number Publication Date
ATE231187T1 true ATE231187T1 (de) 2003-02-15

Family

ID=25520753

Family Applications (1)

Application Number Title Priority Date Filing Date
AT93925095T ATE231187T1 (de) 1992-10-29 1993-10-27 Methoden zur detektion von mikrometastasen bei prostata-krebs

Country Status (10)

Country Link
US (2) US5506106A (de)
EP (1) EP0667920B1 (de)
JP (1) JPH08502889A (de)
AT (1) ATE231187T1 (de)
CA (1) CA2148350A1 (de)
DE (1) DE69332642T2 (de)
DK (1) DK0667920T3 (de)
ES (1) ES2191018T3 (de)
PT (1) PT667920E (de)
WO (1) WO1994010343A1 (de)

Families Citing this family (87)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0667920B1 (de) * 1992-10-29 2003-01-15 Thomas Jefferson University Methoden zur detektion von mikrometastasen bei prostata-krebs
US5674682A (en) * 1992-10-29 1997-10-07 Thomas Jefferson University Nucleic acid primers for detecting micrometastasis of prostate cancer
US6103237A (en) * 1993-07-22 2000-08-15 Hybritech Incorporated Stable variant hK2 polypeptide
EP0760006A1 (de) * 1994-04-15 1997-03-05 The Trustees Of Columbia University In The City Of New York Verfahren zur einstufung von prostatakrebs auf molekularer basis
WO1995030758A1 (en) * 1994-05-10 1995-11-16 Mayo Foundation For Medical Education And Research Recombinant hk2 polypeptide
US5599686A (en) * 1994-06-28 1997-02-04 Merck & Co., Inc. Peptides
US6143864A (en) * 1994-06-28 2000-11-07 Merck & Co., Inc. Peptides
US5866679A (en) * 1994-06-28 1999-02-02 Merck & Co., Inc. Peptides
WO1996021042A2 (en) * 1995-01-04 1996-07-11 Trustees Of Boston University Primers for the pcr amplification of metastatic sequences
AUPN274295A0 (en) * 1995-05-02 1995-05-25 Garvan Institute Of Medical Research GDU, a novel signalling protein
US6218529B1 (en) 1995-07-31 2001-04-17 Urocor, Inc. Biomarkers and targets for diagnosis, prognosis and management of prostate, breast and bladder cancer
WO1998004689A1 (en) * 1995-07-31 1998-02-05 Urocor, Inc. Biomarkers and targets for diagnosis, prognosis and management of prostate disease
EP0938320B2 (de) * 1996-03-26 2014-06-18 Michael S. Kopreski Methoden aus plasma oder serum extrahierte extrazelluraere rna zur diagnoseüberwachung oder evaluation von krebs verwenden
US8043835B1 (en) 1996-03-26 2011-10-25 Oncomedx, Inc. Methods for detecting and monitoring cancer using extracellular RNA
US7785842B2 (en) * 1996-03-26 2010-08-31 Oncomedx, Inc. Comparative analysis of extracellular RNA species
US6759217B2 (en) * 1996-03-26 2004-07-06 Oncomedx, Inc. Method enabling use of extracellular RNA extracted from plasma or serum to detect, monitor or evaluate cancer
US5861248A (en) * 1996-03-29 1999-01-19 Urocor, Inc. Biomarkers for detection of prostate cancer
WO1997039139A1 (en) * 1996-04-16 1997-10-23 Smithkline Beecham Corporation A method for detection of prostate specific antigen used in monitoring and diagnosis of prostate cancer
US5925519A (en) 1996-06-03 1999-07-20 The Regents Of The University Of California Genetic alterations associated with prostate cancer
EP0941368A2 (de) * 1996-11-14 1999-09-15 Mayo Foundation For Medical Education And Research Verfahren für den nachweis von metastatischem prostatakrebs
US6479263B1 (en) * 1996-11-14 2002-11-12 Baylor College Of Medicine Method for detection of micrometastatic prostate cancer
CA2273847C (en) * 1996-12-06 2013-08-13 Urocor, Inc. Diagnosis of disease state using mrna profiles
WO1998040513A1 (en) * 1997-03-11 1998-09-17 Ferrari Anna C Method of detecting prostate cancer metastasis
US20070009934A1 (en) * 1997-03-14 2007-01-11 Kopreski Michael S Method enabling use of extracellular RNA extracted from plasma or serum to detect, monitor or evaluate cancer
US8440396B2 (en) * 1997-03-14 2013-05-14 Oncomedx, Inc. Method enabling use of extracellular RNA extracted from plasma or serum to detect, monitor or evaluate cancer
US7332270B1 (en) 1997-03-24 2008-02-19 Urocor, Inc. Diagnosis of disease state using mRNA profiles in peripheral leukocytes
US6190857B1 (en) * 1997-03-24 2001-02-20 Urocor, Inc. Diagnosis of disease state using MRNA profiles in peripheral leukocytes
JP5284554B2 (ja) * 1997-04-30 2013-09-11 ハイブリテック インコーポレイテッド 前立腺特異的抗原の形態およびその検出方法
US7288636B2 (en) 1997-04-30 2007-10-30 Hybritech Incorporated Forms of prostate specific antigens and methods for their detection
US7659073B2 (en) 1997-04-30 2010-02-09 Hybritech Incorporated Forms of prostate specific antigens and methods for their detection
NO972006D0 (no) * 1997-04-30 1997-04-30 Forskningsparken I Aas As Ny metode for diagnose av sykdommer
US6235486B1 (en) 1997-06-20 2001-05-22 Mayo Foundation For Medical Education & Research Method for detection of breast cancer
DE19736691A1 (de) * 1997-08-22 1999-02-25 Michael Prof Dr Med Giesing Verfahren zur Charakterisierung und Identifizierung disseminierter und metastasierter Krebszellen
CA2303404A1 (en) * 1997-09-11 1999-03-18 Abbott Laboratories Reagents and methods useful for detecting diseases of the prostate
US6300088B1 (en) 1997-11-24 2001-10-09 Duke University Method of detecting prostate specific antigen
US5972615A (en) 1998-01-21 1999-10-26 Urocor, Inc. Biomarkers and targets for diagnosis, prognosis and management of prostate disease
US6673914B1 (en) 1998-01-22 2004-01-06 John Wayne Cancer Institute Human tumor-associated gene
AU3590199A (en) 1998-05-01 1999-11-23 Queen's University At Kingston Method for diagnosing a vascular condition
US6861215B1 (en) * 1998-05-21 2005-03-01 Diadexus, Inc. Method of diagnosing, monitoring, and staging prostate cancer
EP1082460A4 (de) * 1998-05-21 2003-02-12 Diadexus Inc Neuartiges verfahren zur diagnose, zur überwachung und verlaufsbeobachtung von prostatakrebs
WO2000005376A1 (en) * 1998-07-24 2000-02-03 The Government Of The United States Of America, Represented By The Secretary, Department Of Health And Human Services Pb 39, a gene dysregulated in prostate cancer, and uses thereof
US7226731B1 (en) 1998-07-24 2007-06-05 The United States Of America, As Represented By The Secretary Of The Department Of Health And Human Services PB 39, a gene dysregulated in prostate cancer, and uses thereof
FR2782730B1 (fr) * 1998-08-25 2002-05-17 Biocom Sa Procede de separation cellulaire pour l'isolation de cellules pathogeniques, notamment cancereuses rares, equipement et reactif pour la mise en oeuvre du procede et application du procede
US20060204989A1 (en) * 1998-09-22 2006-09-14 Kopreski Michael S Comparative analysis of extracellular RNA species
US8163524B2 (en) * 1998-09-22 2012-04-24 Oncomedx, Inc. Comparative analysis of extracellular RNA species
US20080261292A1 (en) * 1998-09-22 2008-10-23 Oncomedx, Inc. Method Enabling the Use of Extracellular Ribonucleic Acid (RNA) Extracted from Plasma or Serum to Detect, Monitor or Evaluate Cancer or Premalignant Conditions
WO2000044940A2 (en) 1999-01-28 2000-08-03 Gen-Probe Incorporated Nucleic acid sequences for detecting genetic markers for cancer in a biological sample
US6156515A (en) * 1999-02-09 2000-12-05 Urocor, Inc. Prostate-specific gene for diagnosis, prognosis and management of prostate cancer
US6875854B1 (en) 1999-11-18 2005-04-05 The Brigham And Women's Hospital, Inc. Compositions and methods for the improved diagnosis and treatment of germ cell tumors
DE60239470D1 (de) * 2001-07-25 2011-04-28 Oncomedx Inc Verfahren zur bewertung pathologischer krankheitszustände unter verwendung extrazellulärer rna
US20100159464A1 (en) * 2001-11-05 2010-06-24 Oncomedx, Inc. Method for Detection of DNA Methyltransferase RNA in Plasma and Serum
US20030104454A1 (en) * 2001-11-05 2003-06-05 Kopreski Michael S. Method for detection of DNA methyltransferase RNA in plasma and serum
CA2432365A1 (en) * 2003-06-30 2004-12-30 Jack A. Schalken Specific method of prostate cancer detection based on pca3, and kits therefore
CN103866018B (zh) * 2005-08-01 2016-05-25 俄亥俄州立大学研究基金会 用于乳腺癌的诊断、预后和治疗的基于MicroRNA的方法和组合物
CN101296702B (zh) * 2005-09-12 2012-11-28 俄亥俄州立大学研究基金会 用于诊断或治疗bcl2相关癌症的组合物和方法
WO2007044413A2 (en) * 2005-10-05 2007-04-19 The Ohio State University Research Foundation Wwox gene, vectors containing the same, and uses in treatment of cancer
AU2007205257B2 (en) 2006-01-05 2013-07-25 The Ohio State University Research Foundation MicroRNA expression abnormalities in pancreatic endocrine and acinar tumors
EP2502630B1 (de) 2006-01-05 2015-03-11 The Ohio State University Research Foundation Verfahren und Zusammensetzungen auf Mikro-RNA-Basis zur Diagnose, Prognose und Behandlung von Lungenkrebs
ES2527592T3 (es) 2006-01-05 2015-01-27 The Ohio State University Research Foundation Métodos basados en microARN para el diagnóstico del cáncer de colon
AU2007227423B2 (en) 2006-03-20 2013-11-07 The Ohio State University Research Foundation MicroRNA fingerprints during human megakaryocytopoiesis
AU2007272947B2 (en) * 2006-07-13 2013-06-06 The Government Of The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services Micro-RNA-based methods and compositions for the diagnosis and treatment of colon cancer-related diseases
AU2007346101B2 (en) * 2006-09-19 2013-08-15 The Ohio State University Research Foundation TCL1 expression in chronic lymphocytic leukemia (CLL) regulated by miR-29 and miR-181
CA2667617A1 (en) 2006-11-01 2008-05-08 The Ohio State University Research Foundation Microrna expression signature for predicting survival and metastases in hepatocellular carcinoma
WO2008094545A2 (en) * 2007-01-31 2008-08-07 The Ohio State University Research Foundation Mic orna-based methods and compositions for the treatment of acute myeloid leukemia
AU2008248319B2 (en) * 2007-04-30 2013-09-05 The Ohio State University Research Foundation Methods for differentiating pancreatic cancer from normal pancreatic function and/or chronic pancreatitis
US8465917B2 (en) * 2007-06-08 2013-06-18 The Ohio State University Research Foundation Methods for determining heptocellular carcinoma subtype and detecting hepatic cancer stem cells
CN101918424A (zh) 2007-06-15 2010-12-15 俄亥俄州立大学研究基金会 用于靶向由Drosha介导的微小RNA加工的致癌ALL-1融合蛋白
CN101809169B (zh) * 2007-07-31 2013-07-17 俄亥俄州立大学研究基金会 通过靶向dnmt3a和dnmt3b恢复甲基化的方法
US8465918B2 (en) 2007-08-03 2013-06-18 The Ohio State University Research Foundation Ultraconserved regions encoding ncRNAs
DE102007037008B4 (de) * 2007-08-06 2015-09-10 Siemens Aktiengesellschaft Diagnosesubstanz zur Anwendung in einem Verfahren zur Bestimmung der Aggressivität eines Prostatatumors
CA2926831A1 (en) * 2007-08-22 2009-02-26 The Ohio State University Research Foundation Methods and compositions for inducing deregulation of epha7 and erk phosphorylation in human acute leukemias
CA2698771A1 (en) * 2007-09-06 2009-03-12 The Ohio State University Research Foundation Microrna signatures in human ovarian cancer
US20090136942A1 (en) * 2007-09-18 2009-05-28 Oncomedx, Inc. Analysis of Extracellular RNA
WO2009049129A1 (en) * 2007-10-11 2009-04-16 The Ohio State University Research Foundation Methods and compositions for the diagnosis and treatment of esphageal adenocarcinomas
EP2201112A4 (de) 2007-10-26 2011-02-02 Univ Ohio State Res Found Verfahren zur identifizierung einer fhit-interaktion und verwendung
CN101918594A (zh) * 2007-11-30 2010-12-15 俄亥俄州立大学研究基金会 肺癌中外周血中的微rna表达特征谱和靶向
EP2799557B1 (de) * 2008-02-28 2016-09-07 The Ohio State University Research Foundation MiR-32 Antagonisten zur Erhöhung der Empfindlichkeit von Prostatakrebszellen für Apoptose
AU2009219193A1 (en) * 2008-02-28 2009-09-03 The Ohio State University Research Foundation MicroRNA signatures associated with human chronic lymphocytic leukemia (CCL) and uses thereof
ES2433940T3 (es) 2008-06-11 2013-12-13 The Government Of The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services Uso de la familia miR-26 como marcador predictivo del carcinoma hepatocelular y sensibilidad a la terapia
CN102803511A (zh) 2009-11-23 2012-11-28 俄亥俄州立大学 用于影响肿瘤细胞生长、迁移和侵袭的材料和方法
WO2012065049A1 (en) 2010-11-12 2012-05-18 The Ohio State University Research Foundation Materials and methods related to microrna-21, mismatch repair, and colorectal cancer
CA2817982C (en) 2010-11-15 2020-06-30 The Regents Of The University Of Michigan Controlled release mucoadhesive systems
US8664192B2 (en) 2011-03-07 2014-03-04 The Ohio State University Mutator activity induced by microRNA-155 (miR-155) links inflammation and cancer
JP2014530612A (ja) 2011-10-14 2014-11-20 ジ・オハイオ・ステート・ユニバーシティ 卵巣がんに関する方法および材料
CN104619353A (zh) 2011-12-13 2015-05-13 俄亥俄州国家创新基金会 与miR-21和miR-29a相关的方法和组合物、外切体抑制和癌症转移
WO2013110053A1 (en) 2012-01-20 2013-07-25 The Ohio State University Breast cancer biomarker signatures for invasiveness and prognosis
CN111518170A (zh) * 2020-05-09 2020-08-11 新乡医学院 基于fret的psa荧光探针、制备方法及其应用

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4446122A (en) * 1979-12-28 1984-05-01 Research Corporation Purified human prostate antigen
US5176995A (en) * 1985-03-28 1993-01-05 Hoffmann-La Roche Inc. Detection of viruses by amplification and hybridization
US5153118A (en) * 1985-12-17 1992-10-06 Eastern Virginia Medical Authority Monoclonal antibodies having binding specificity to human prostate tumor-associated antigens and methods for employing the same
US4803169A (en) * 1986-02-05 1989-02-07 Cetus Corporation Assay for human breast cancer
US5085983A (en) * 1988-08-19 1992-02-04 City Of Hope Detection of human tumor progression and drug resistance
AU662906B2 (en) * 1991-06-26 1995-09-21 F. Hoffmann-La Roche Ag Methods for detection of carcinoma metastases by nucleic acid amplification
EP0667920B1 (de) * 1992-10-29 2003-01-15 Thomas Jefferson University Methoden zur detektion von mikrometastasen bei prostata-krebs

Also Published As

Publication number Publication date
US5506106A (en) 1996-04-09
US5688649A (en) 1997-11-18
EP0667920B1 (de) 2003-01-15
CA2148350A1 (en) 1994-05-11
DE69332642D1 (de) 2003-02-20
JPH08502889A (ja) 1996-04-02
WO1994010343A1 (en) 1994-05-11
PT667920E (pt) 2003-06-30
ES2191018T3 (es) 2003-09-01
DE69332642T2 (de) 2003-10-02
EP0667920A1 (de) 1995-08-23
EP0667920A4 (de) 1998-12-16
DK0667920T3 (da) 2003-04-14

Similar Documents

Publication Publication Date Title
ATE231187T1 (de) Methoden zur detektion von mikrometastasen bei prostata-krebs
DE3853678T2 (de) Verfahren zum nachweis des karzinogenen menschlichen papillomavirus.
DE69637047D1 (de) Unabhängiges gerät zur extraktion, amplifikation und nachweis von nukleinsäuren
FR2703693B1 (fr) Procédé rapide de détermination d'une séquence d'ADN et application au séquençage et au diagnostic.
DE69635848D1 (de) Verfahren zum Nachweis von Ki-ras Mutationen
DE58909587D1 (de) Verfahren zum Nachweis von gesplei ter mRNA
DE69605908D1 (de) Benutzung von reagenzien abgeleitet vom menschlichen metastase unterdrückungs gen kai1 in diagnostischen und gen-terapeutischen verfahren
IL81695A (en) Quantitative determination of the degree of amplification of genes and/or corresponding messenger rna and reagent kit for performing the determination
ES2166822T3 (es) Procedimientos de seleccion de la enfermedad de crohn usando alelos de microsatelites de tnf.
ATE250673T1 (de) Verfahren zur identifizierung metastatischer sequenzen
EP0329198A3 (de) Ribose- und 2-Deoxyribose-Verbindungen
IL92956A0 (en) Gene sequences which encode acylpeptide hydrolase and methods for detecting cancer utilizing the same
ATE184055T1 (de) Verfahren zum sensitiven nachweis von reverser transcriptase
DE59309971D1 (de) Spezifischer Nachweis von Neisseria gonorrhoeae
ATE219247T1 (de) Methoden zur feststellung von alzheimerscher krankheit
FR2720757B1 (fr) Procédé et sondes pour la détection de marqueurs liés au locus des amyotrophies spinales infantiles.
DE69214843T2 (de) Verfahren zum nachweis von beschädigungen des magenepithels
GB9510954D0 (en) Detection of DNA damage
NO901461D0 (no) Antistoffer mot retinoblastomgenprodukt og anvendelse derav.
FR2678285B1 (de)
ATE251223T1 (de) Immuno-magnetische zelltrennung zur erkennung von krebsmetastasenbildung-assozierten genen
ATE384266T1 (de) Verfahren zur prognose des kumulativen überlebens von patienten
DE69621791D1 (de) Verfahren zur bestimmung von crohn's krankheit und colitis ulcerosa
DE69635025D1 (de) Neues verfahren zum nachweis von cryptosporidium
FI973762A0 (fi) Ny gen

Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification

Ref document number: 0667920

Country of ref document: EP

REN Ceased due to non-payment of the annual fee