WO2005062937A2 - Methods and compositions for enhancing the efficacy and specificity of single and double blunt-ended sirna - Google Patents

Methods and compositions for enhancing the efficacy and specificity of single and double blunt-ended sirna Download PDF

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Publication number
WO2005062937A2
WO2005062937A2 PCT/US2004/043359 US2004043359W WO2005062937A2 WO 2005062937 A2 WO2005062937 A2 WO 2005062937A2 US 2004043359 W US2004043359 W US 2004043359W WO 2005062937 A2 WO2005062937 A2 WO 2005062937A2
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WO
WIPO (PCT)
Prior art keywords
end
strand
base pair
method
sirna duplex
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Application number
PCT/US2004/043359
Other languages
French (fr)
Other versions
WO2005062937A3 (en
Inventor
Phillip D. Zamore
Original Assignee
University Of Massachusetts
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Publication date
Priority to US53211603P priority Critical
Priority to US60/532,116 priority
Application filed by University Of Massachusetts filed Critical University Of Massachusetts
Publication of WO2005062937A2 publication Critical patent/WO2005062937A2/en
Publication of WO2005062937A3 publication Critical patent/WO2005062937A3/en

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