JP2015532097A5 - - Google Patents
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- Publication number
- JP2015532097A5 JP2015532097A5 JP2015534781A JP2015534781A JP2015532097A5 JP 2015532097 A5 JP2015532097 A5 JP 2015532097A5 JP 2015534781 A JP2015534781 A JP 2015534781A JP 2015534781 A JP2015534781 A JP 2015534781A JP 2015532097 A5 JP2015532097 A5 JP 2015532097A5
- Authority
- JP
- Japan
- Prior art keywords
- seq
- polynucleotide
- sequence number
- composition
- immune response
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 108091033319 polynucleotide Proteins 0.000 claims description 87
- 239000002157 polynucleotide Substances 0.000 claims description 87
- 102000040430 polynucleotide Human genes 0.000 claims description 87
- 230000028993 immune response Effects 0.000 claims description 30
- 125000003729 nucleotide group Chemical group 0.000 claims description 29
- 239000002773 nucleotide Substances 0.000 claims description 23
- 208000023275 Autoimmune disease Diseases 0.000 claims description 20
- 230000001419 dependent effect Effects 0.000 claims description 20
- 230000002401 inhibitory effect Effects 0.000 claims description 18
- 101000800483 Homo sapiens Toll-like receptor 8 Proteins 0.000 claims description 15
- 102100033110 Toll-like receptor 8 Human genes 0.000 claims description 15
- 239000008194 pharmaceutical composition Substances 0.000 claims description 13
- 208000027866 inflammatory disease Diseases 0.000 claims description 9
- 101000669402 Homo sapiens Toll-like receptor 7 Proteins 0.000 claims description 8
- 102100039390 Toll-like receptor 7 Human genes 0.000 claims description 8
- 239000000546 pharmaceutical excipient Substances 0.000 claims description 8
- 208000024891 symptom Diseases 0.000 claims description 8
- 108091032973 (ribonucleotides)n+m Proteins 0.000 claims description 6
- 208000021386 Sjogren Syndrome Diseases 0.000 claims description 6
- CTMZLDSMFCVUNX-VMIOUTBZSA-N cytidylyl-(3'->5')-guanosine Chemical compound O=C1N=C(N)C=CN1[C@H]1[C@H](O)[C@H](OP(O)(=O)OC[C@@H]2[C@H]([C@@H](O)[C@@H](O2)N2C3=C(C(N=C(N)N3)=O)N=C2)O)[C@@H](CO)O1 CTMZLDSMFCVUNX-VMIOUTBZSA-N 0.000 claims description 6
- 208000037979 autoimmune inflammatory disease Diseases 0.000 claims description 5
- 208000003343 Antiphospholipid Syndrome Diseases 0.000 claims description 4
- 208000003250 Mixed connective tissue disease Diseases 0.000 claims description 4
- 206010033645 Pancreatitis Diseases 0.000 claims description 4
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 4
- 208000002551 irritable bowel syndrome Diseases 0.000 claims description 4
- 206010039073 rheumatoid arthritis Diseases 0.000 claims description 4
- 201000000596 systemic lupus erythematosus Diseases 0.000 claims description 4
- 108091030071 RNAI Proteins 0.000 claims description 3
- 230000000692 anti-sense effect Effects 0.000 claims description 3
- 230000009368 gene silencing by RNA Effects 0.000 claims description 3
- RYYWUUFWQRZTIU-UHFFFAOYSA-K thiophosphate Chemical compound [O-]P([O-])([O-])=S RYYWUUFWQRZTIU-UHFFFAOYSA-K 0.000 claims description 3
- 239000000203 mixture Substances 0.000 claims 32
- 229910019142 PO4 Inorganic materials 0.000 claims 2
- 206010012601 diabetes mellitus Diseases 0.000 claims 2
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 claims 2
- 239000010452 phosphate Substances 0.000 claims 2
- 239000000644 isotonic solution Substances 0.000 claims 1
- 238000000034 method Methods 0.000 description 18
- 239000003814 drug Substances 0.000 description 5
- 102000008235 Toll-Like Receptor 9 Human genes 0.000 description 4
- 108010060818 Toll-Like Receptor 9 Proteins 0.000 description 4
- 230000004048 modification Effects 0.000 description 3
- 238000012986 modification Methods 0.000 description 3
- 206010067584 Type 1 diabetes mellitus Diseases 0.000 description 2
- 108090000765 processed proteins & peptides Proteins 0.000 description 2
- 206010061218 Inflammation Diseases 0.000 description 1
- 230000002159 abnormal effect Effects 0.000 description 1
- 230000001668 ameliorated effect Effects 0.000 description 1
- 125000002091 cationic group Chemical group 0.000 description 1
- 230000001934 delay Effects 0.000 description 1
- 230000004054 inflammatory process Effects 0.000 description 1
- 230000011664 signaling Effects 0.000 description 1
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261707887P | 2012-09-29 | 2012-09-29 | |
| US61/707,887 | 2012-09-29 | ||
| US201361761214P | 2013-02-05 | 2013-02-05 | |
| US61/761,214 | 2013-02-05 | ||
| US13/842,861 | 2013-03-15 | ||
| US13/842,861 US9228184B2 (en) | 2012-09-29 | 2013-03-15 | Human toll-like receptor inhibitors and methods of use thereof |
| PCT/US2013/062479 WO2014052931A1 (en) | 2012-09-29 | 2013-09-27 | Human toll-like receptor inhibitors and methods of use thereof |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2015532097A JP2015532097A (ja) | 2015-11-09 |
| JP2015532097A5 true JP2015532097A5 (enExample) | 2016-11-10 |
| JP6395266B2 JP6395266B2 (ja) | 2018-09-26 |
Family
ID=50385792
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015534781A Active JP6395266B2 (ja) | 2012-09-29 | 2013-09-27 | ヒトＴｏｌｌ様受容体阻害剤およびその使用方法 |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US9228184B2 (enExample) |
| EP (1) | EP2900823B1 (enExample) |
| JP (1) | JP6395266B2 (enExample) |
| CN (1) | CN104937102A (enExample) |
| AU (1) | AU2013202255B2 (enExample) |
| CA (1) | CA2886755A1 (enExample) |
| WO (1) | WO2014052931A1 (enExample) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8158768B2 (en) * | 2002-12-23 | 2012-04-17 | Dynavax Technologies Corporation | Immunostimulatory sequence oligonucleotides and methods of using the same |
| US9868955B2 (en) | 2012-09-29 | 2018-01-16 | Dynavax Technologies Corporation | Human toll-like receptor inhibitors and methods of use thereof |
| TW201630606A (zh) * | 2015-01-21 | 2016-09-01 | 諾華公司 | 包含局部藥物之蓋崙（ｇａｌｅｎｉｃ）調配物 |
| US20180036335A1 (en) * | 2015-03-03 | 2018-02-08 | Ionis Pharmaceuticals, Inc. | Compositions for modulating mecp2 expression |
| US11129844B2 (en) | 2015-03-03 | 2021-09-28 | Ionis Pharmaceuticals, Inc. | Compositions and methods for modulating MECP2 expression |
| WO2017136399A1 (en) * | 2016-02-02 | 2017-08-10 | Idera Pharmaceuticals, Inc. | POTENTIATION OF mmRNA THERAPEUTICS |
| CN116832169A (zh) * | 2016-09-02 | 2023-10-03 | 箭头药业股份有限公司 | 靶向配体 |
| US11370794B2 (en) | 2016-11-11 | 2022-06-28 | Dynavax Technologies Corporation | Toll-like receptor antagonist compounds and methods of use |
| CN119548615A (zh) * | 2017-06-30 | 2025-03-04 | 皇家墨尔本理工大学 | 一种治疗方法 |
| JP2022544412A (ja) | 2019-08-14 | 2022-10-18 | キュアバック アーゲー | 免疫賦活特性が減少したｒｎａ組み合わせおよび組成物 |
| AU2020407871A1 (en) | 2019-12-20 | 2022-06-30 | Nammi Therapeutics, Inc. | Formulated and/or co-formulated liposome compositions containing toll-like receptor ("TLR") agonist prodrugs useful in the treatment of cancer and methods thereof |
| KR20230165907A (ko) * | 2021-04-08 | 2023-12-05 | 허드슨 인스티튜트 오브 메디컬 리서치 | 올리고뉴클레오티드 |
| US12152052B2 (en) | 2022-09-23 | 2024-11-26 | Ionis Pharmaceuticals, Inc. | Compounds and methods for reducing MECP2 expression |
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| AU2005282889B2 (en) | 2004-09-01 | 2012-03-15 | Dynavax Technologies Corporation | Methods and conpositions for inhibition of innate immune responses and autoimmunity |
| JP2008523084A (ja) | 2004-12-08 | 2008-07-03 | スリーエム イノベイティブ プロパティズ カンパニー | 免疫賦活用合剤および方法 |
| CA2591582A1 (en) | 2004-12-17 | 2006-06-22 | Dynavax Technologies Corporation | Methods and compositions for induction or promotion of immune tolerance |
| WO2006091591A1 (en) | 2005-02-22 | 2006-08-31 | The Regents Of The University Of California | Methods of treating gastrointestinal inflammation |
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| TW201402124A (zh) | 2005-08-19 | 2014-01-16 | Array Biopharma Inc | 作為類鐸受體（ｔｏｌｌ-ｌｉｋｅ ｒｅｃｅｐｔｏｒ）調節劑之８-經取代苯并氮雜呯 |
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| KR101221589B1 (ko) * | 2006-04-07 | 2013-01-15 | 이데라 파마슈티칼즈, 인코포레이티드 | Ｔｌｒ７ 및 ｔｌｒ８에 대한 안정화된 면역 조절성 ｒｎａ〔ｓｉｍｒａ〕 화합물 |
| WO2007143582A2 (en) | 2006-06-05 | 2007-12-13 | Baylor College Of Medicine | Reversal of the suppressive function of specific t cells via toll-like receptor 8 signaling |
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| JP5737937B2 (ja) | 2007-07-09 | 2015-06-17 | イデラ ファーマシューティカルズ インコーポレイテッドＩｄｅｒａ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ， Ｉｎｃ． | 安定化免疫調節ｒｎａ（ｓｉｍｒａ）化合物 |
| CA2703931C (en) | 2007-10-26 | 2016-08-16 | Dynavax Technologies Corporation | Methods and compositions for inhibition of immune responses and autoimmunity |
| WO2009154610A1 (en) | 2008-06-17 | 2009-12-23 | Idera Pharmaceuticals, Inc. | Immune regulatory oligonucleotide (iro) compounds to modulate toll-like receptor based immune response |
| US20100047188A1 (en) | 2008-08-04 | 2010-02-25 | Idera Pharmaceuticals, Inc. | Modulation of toll-like receptor 8 expression by antisense oligonucleotides |
| US8940310B2 (en) | 2010-06-16 | 2015-01-27 | Dynavax Technologies Corporation | Methods of treatment using TLR7 and/or TLR9 inhibitors |
| JP5921535B2 (ja) | 2010-06-16 | 2016-05-24 | ディナバックス テクノロジーズ コーポレイション | Ｔｌｒ７および／またはｔｌｒ９阻害剤を用いる治療の方法 |
| AU2012236345B2 (en) | 2011-03-29 | 2014-10-02 | Dynavax Technologies Corporation | TLR8 transgenic animals |
-
2013
- 2013-03-15 US US13/842,861 patent/US9228184B2/en active Active
- 2013-04-02 AU AU2013202255A patent/AU2013202255B2/en not_active Ceased
- 2013-09-27 EP EP13773582.5A patent/EP2900823B1/en active Active
- 2013-09-27 CN CN201380050891.5A patent/CN104937102A/zh active Pending
- 2013-09-27 WO PCT/US2013/062479 patent/WO2014052931A1/en not_active Ceased
- 2013-09-27 CA CA2886755A patent/CA2886755A1/en active Pending
- 2013-09-27 JP JP2015534781A patent/JP6395266B2/ja active Active
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