CA2997319C - Combination comprising immunostimulatory oligonucleotides - Google Patents
Combination comprising immunostimulatory oligonucleotides Download PDFInfo
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- CA2997319C CA2997319C CA2997319A CA2997319A CA2997319C CA 2997319 C CA2997319 C CA 2997319C CA 2997319 A CA2997319 A CA 2997319A CA 2997319 A CA2997319 A CA 2997319A CA 2997319 C CA2997319 C CA 2997319C
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Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| LU92821 | 2015-09-09 | ||
| LU92821A LU92821B1 (en) | 2015-09-09 | 2015-09-09 | Combination comprising immunostimulatory oligonucleotides |
| PCT/EP2016/071314 WO2017042336A1 (en) | 2015-09-09 | 2016-09-09 | Combination comprising immunostimulatory oligonucleotides |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CA2997319A1 CA2997319A1 (en) | 2017-03-16 |
| CA2997319C true CA2997319C (en) | 2023-01-10 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA2997319A Active CA2997319C (en) | 2015-09-09 | 2016-09-09 | Combination comprising immunostimulatory oligonucleotides |
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| Country | Link |
|---|---|
| US (3) | US10487333B2 (enExample) |
| EP (1) | EP3347468B1 (enExample) |
| JP (3) | JP2018530530A (enExample) |
| KR (1) | KR102411799B1 (enExample) |
| CN (1) | CN108138179B (enExample) |
| AU (1) | AU2016319214B2 (enExample) |
| CA (1) | CA2997319C (enExample) |
| ES (1) | ES2905891T3 (enExample) |
| IL (1) | IL257921B (enExample) |
| LU (1) | LU92821B1 (enExample) |
| MX (1) | MX2018002665A (enExample) |
| PL (1) | PL3347468T3 (enExample) |
| PT (1) | PT3347468T (enExample) |
| RU (1) | RU2766693C2 (enExample) |
| SI (1) | SI3347468T1 (enExample) |
| WO (1) | WO2017042336A1 (enExample) |
| ZA (1) | ZA201801001B (enExample) |
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| KR20160042917A (ko) | 2013-07-25 | 2016-04-20 | 엑시큐어, 인크. | 예방 및 치료 용도를 위한 면역자극제로서의 구형 핵산-기재 구축물 |
| AU2015349680A1 (en) | 2014-11-21 | 2017-06-08 | Northwestern University | The sequence-specific cellular uptake of spherical nucleic acid nanoparticle conjugates |
| LU92821B1 (en) | 2015-09-09 | 2017-03-20 | Mologen Ag | Combination comprising immunostimulatory oligonucleotides |
| GB2542425A (en) | 2015-09-21 | 2017-03-22 | Mologen Ag | Means for the treatment of HIV |
| BR112018006237A2 (pt) | 2015-09-29 | 2018-10-09 | Celgene Corp | proteínas de ligação a pd-1 e métodos de uso das mesmas |
| CN109689694B (zh) | 2016-05-19 | 2022-11-22 | 通用医疗公司 | 与其受体IL-2Rβ结合的IL2作为用来增强自然杀伤细胞和调节性T细胞活性的平台 |
| WO2018039629A2 (en) | 2016-08-25 | 2018-03-01 | Northwestern University | Micellar spherical nucleic acids from thermoresponsive, traceless templates |
| JP2019534859A (ja) | 2016-09-19 | 2019-12-05 | セルジーン コーポレイション | Pd−1結合タンパク質を使用して白斑を治療する方法 |
| US10751414B2 (en) | 2016-09-19 | 2020-08-25 | Celgene Corporation | Methods of treating psoriasis using PD-1 binding antibodies |
| EP3392345A1 (en) | 2017-04-22 | 2018-10-24 | Mologen AG | Biomarker for small cell lung cancer therapy |
| US11433131B2 (en) | 2017-05-11 | 2022-09-06 | Northwestern University | Adoptive cell therapy using spherical nucleic acids (SNAs) |
| WO2019043194A1 (en) * | 2017-08-31 | 2019-03-07 | Mologen Ag | TLR-9 AGONISTS FOR TUMOR MICROENVIRONMENT MODULATION |
| WO2019200238A1 (en) | 2018-04-14 | 2019-10-17 | Dynavax Technologies Corporation | Combinations including a cpg-c type oligonucleotide and a histone deacetylase inhibitor for treating cancer |
| WO2020206169A1 (en) | 2019-04-02 | 2020-10-08 | Kupper Thomas S | Methods for identifying progression of a primary melanoma |
| CN112007149A (zh) * | 2019-05-29 | 2020-12-01 | 思格(苏州)生物科技有限公司 | 一种新型复合免疫佐剂及其应用 |
Family Cites Families (82)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB191115253A (en) | 1911-06-30 | 1912-06-20 | Adolph Schneider | Improvements in Bottle-filling Machines. |
| US2382696A (en) | 1939-04-01 | 1945-08-14 | Milleville Marie Joseph Mau De | Method and apparatus for filling containers |
| GB684057A (en) | 1949-11-30 | 1952-12-10 | Stockholms Bryggerier Ab | Machine of the rotatory table type for the treatment of bottles and the like containers |
| US2699718A (en) | 1952-04-10 | 1955-01-18 | Francis X Wright | Filling apparatus with beverage preparation mechanism |
| FR1418965A (fr) | 1964-10-14 | 1965-11-26 | Chelle Ets | Tireuse de liquides à double utilisation |
| AU554222B2 (en) | 1981-10-13 | 1986-08-14 | Toyo Garasu K.K. | Inspecting glass containers |
| EP0464638B1 (de) | 1990-07-02 | 1997-04-02 | Hoechst Aktiengesellschaft | Oligonucleotid-analoge mit terminalen 3'-3'-bzw. 5'-5'-Internucleotidverknüpfungen |
| WO1995006731A2 (en) | 1993-09-02 | 1995-03-09 | Ribozyme Pharmaceuticals, Inc. | Non-nucleotide containing enzymatic nucleic acid |
| WO1995026204A1 (en) | 1994-03-25 | 1995-10-05 | Isis Pharmaceuticals, Inc. | Immune stimulation by phosphorothioate oligonucleotide analogs |
| US20030050263A1 (en) | 1994-07-15 | 2003-03-13 | The University Of Iowa Research Foundation | Methods and products for treating HIV infection |
| US6207646B1 (en) | 1994-07-15 | 2001-03-27 | University Of Iowa Research Foundation | Immunostimulatory nucleic acid molecules |
| FR2732971B1 (fr) | 1995-04-13 | 1997-07-04 | Genset Sa | Oligonucleotide sens inhibiteur de virus herpes simplex (hsv) a structure en haltere |
| US5856462A (en) | 1996-09-10 | 1999-01-05 | Hybridon Incorporated | Oligonucleotides having modified CpG dinucleosides |
| CA2267279A1 (en) | 1996-10-16 | 1998-04-23 | Devron Averett | Monocyclic l-nucleosides, analogs and uses thereof |
| DE19648625A1 (de) | 1996-11-13 | 1998-05-14 | Soft Gene Gmbh | Mikroprojektil für das Einbringen von Substanzen in Zellen durch ballistischen Transfer |
| EP0855184A1 (en) | 1997-01-23 | 1998-07-29 | Grayson B. Dr. Lipford | Pharmaceutical composition comprising a polynucleotide and an antigen especially for vaccination |
| US6251666B1 (en) | 1997-03-31 | 2001-06-26 | Ribozyme Pharmaceuticals, Inc. | Nucleic acid catalysts comprising L-nucleotide analogs |
| US6589940B1 (en) | 1997-06-06 | 2003-07-08 | Dynavax Technologies Corporation | Immunostimulatory oligonucleotides, compositions thereof and methods of use thereof |
| US6192481B1 (en) | 1998-08-18 | 2001-02-20 | International Business Machines Corporation | Structure and method for power sequencing of disk drives in a computer system |
| ES2228454T3 (es) | 1999-02-26 | 2005-04-16 | Chiron S.R.L. | Mejora de la actividad bacteriana de antigenos de neisseria con oligonucleotidos que contienen motivos cg. |
| US6977245B2 (en) | 1999-04-12 | 2005-12-20 | The United States Of America As Represented By The Department Of Health And Human Services | Oligodeoxynucleotide and its use to induce an immune response |
| US6737066B1 (en) | 1999-05-06 | 2004-05-18 | The Immune Response Corporation | HIV immunogenic compositions and methods |
| CA2376992A1 (en) | 1999-06-29 | 2001-01-04 | Smithkline Beecham Biologicals S.A. | Use of cpg as an adjuvant for hiv vaccine |
| DE19935756A1 (de) | 1999-07-27 | 2001-02-08 | Mologen Forschungs Entwicklung | Kovalent geschlossenes Nukleinsäuremolekül zur Immunstimulation |
| WO2001040515A1 (en) | 1999-11-12 | 2001-06-07 | Isis Pharmaceuticals, Inc. | Gapped oligomers having site specific chiral phosphorothioate internucleoside linkages |
| JP2004509970A (ja) | 2000-09-26 | 2004-04-02 | ハイブリドン・インコーポレイテッド | 位置的化学変化による免疫刺激オリゴヌクレオチドアナログの免疫刺激活性の調節 |
| DE10290185D2 (de) | 2001-01-31 | 2004-04-15 | Mologen Forschungs Entwicklung | Tumorvakzine |
| CA2452458A1 (en) | 2001-07-03 | 2003-01-16 | Isis Pharmaceuticals, Inc. | Nuclease resistant chimeric oligonucleotides |
| ES2242888T3 (es) | 2001-10-02 | 2005-11-16 | Mologen Ag | Constructo de expresion de adn para el tratamiento de infecciones por leishmaniosis. |
| EP1432439B1 (de) | 2001-10-02 | 2005-12-07 | Mologen AG | Mittel zur verbesserung der immunantwort |
| US7276489B2 (en) | 2002-10-24 | 2007-10-02 | Idera Pharmaceuticals, Inc. | Modulation of immunostimulatory properties of oligonucleotide-based compounds by optimal presentation of 5′ ends |
| WO2003035836A2 (en) | 2001-10-24 | 2003-05-01 | Hybridon Inc. | Modulation of immunostimulatory properties of oligonucleotide-based compounds by optimal presentation of 5' ends |
| JP2003204793A (ja) | 2002-01-15 | 2003-07-22 | Takeda Chem Ind Ltd | ウイルス性疾患の予防または治療剤 |
| DE10211558A1 (de) | 2002-03-15 | 2003-10-09 | Noxxon Pharma Ag | Neue Formen RNAi |
| US7605138B2 (en) | 2002-07-03 | 2009-10-20 | Coley Pharmaceutical Group, Inc. | Nucleic acid compositions for stimulating immune responses |
| WO2004041183A2 (en) | 2002-11-01 | 2004-05-21 | The Regents Of The University Of California | Methods of treating pulmonary fibrotic disorders |
| US8158768B2 (en) | 2002-12-23 | 2012-04-17 | Dynavax Technologies Corporation | Immunostimulatory sequence oligonucleotides and methods of using the same |
| US7501503B2 (en) | 2002-12-31 | 2009-03-10 | Mcgill University | Compositions and methods for inhibiting RNase H activity of retroid reverse transcriptase |
| BRPI0408623A (pt) | 2003-03-26 | 2006-03-07 | Cytos Biotechnology Ag | conjugados de partìcula semelhante ao vìrus análogo de peptìdeo de melan-a |
| EP1631672B1 (de) | 2003-06-10 | 2006-09-20 | Mologen AG | Zirkuläres expressionskonstrukt für gentherapeutische anwendungen |
| CA2540949A1 (en) | 2003-10-30 | 2005-05-12 | Coley Pharmaceutical Gmbh | C-class oligonucleotide analogs with enhanced immunostimulatory potency |
| EP1691817A2 (en) | 2003-12-02 | 2006-08-23 | Corgentech, Inc. | NF-kB OLIGONUCLEOTIDE DECOY MOLECULES |
| WO2005063280A1 (de) | 2003-12-30 | 2005-07-14 | Mologen Ag | Allogenes tumortherapeutikum |
| DK1716234T3 (da) | 2004-02-20 | 2014-01-20 | Mologen Ag | Substitueret, ikke-kodende nukleinsyremolekyle til terapeutisk og profylaktisk immunstimulering i mennesker og højerestående dyr |
| JP3976742B2 (ja) | 2004-02-27 | 2007-09-19 | 江守商事株式会社 | インターフェロンアルファを誘導する免疫刺激オリゴヌクレオチド |
| DK1749096T3 (da) | 2004-05-28 | 2013-10-28 | Mologen Ag | Fremgangsmåde til fremstilling af egnede DNA-konstrukter til specifik inhibering af genekspression ved RNA-interferens |
| HRP20070012A2 (hr) | 2004-06-15 | 2007-10-31 | Idera Pharmaceuticals | Imunostimulatorski oligonukleotidni multimeri |
| WO2006015560A1 (de) | 2004-08-09 | 2006-02-16 | Mologen Ag | Immunmodulierendes mittel in verbindung mit chemotherapeutischen massnahmen |
| BRPI0617254A2 (pt) | 2005-01-12 | 2011-07-19 | Cancer Rec Tech Ltd | "oligonucleotìdeo de filamento único, composição farmacêutica, métodos para estimular a atividade de tlr7 em uma célula que expressa tlr7, para estimular a atividade de tlr8 em uma célula que expressa tlr8, e, para estimular uma resposta imune em um paciente |
| US7879992B2 (en) | 2005-01-31 | 2011-02-01 | Isis Pharmaceuticals, Inc. | Modification of MyD88 splicing using modified oligonucleotides |
| CA2598831A1 (en) | 2005-02-22 | 2006-08-31 | The Regents Of The University Of California | Methods of treating gastrointestinal inflammation |
| EP1899467A2 (en) | 2005-04-26 | 2008-03-19 | Coley Pharmaceutical GmbH | Modified oligoribonucleotide analogs with enhances immunostimulatory activity |
| WO2007047396A2 (en) | 2005-10-12 | 2007-04-26 | Idera Pharmaceuticals, Inc. | Immune regulatory oligonucleotide (iro) compounds to modulate toll-like receptor based immune response |
| JP2009515896A (ja) | 2005-11-11 | 2009-04-16 | ファイザー・インク | 免疫調節性オリゴデオキシヌクレオチドを使用する併用療法 |
| ES2536103T3 (es) | 2005-11-25 | 2015-05-20 | Zoetis Belgium S.A. | Oligorribonucleótidos inmunoestimuladores |
| ES2421314T3 (es) | 2005-11-25 | 2013-08-30 | Mologen Ag | Constructos de ADN para la inhibición específica de la expresión génica mediante interferencia de ARN |
| BRPI0707679A2 (pt) | 2006-02-01 | 2011-05-10 | Tjhe Johns Hopkins University | conjugado de polipetÍdeo - Àcido nuclÉico para imunoprofilaxia ou imunoterapia para distérbios neoplÁsticos ou infecciosos |
| MX2008014380A (es) * | 2006-05-11 | 2009-03-02 | Mologen Ag | Multimero para inmunoestimulacion. |
| WO2007147007A2 (en) | 2006-06-13 | 2007-12-21 | Bayhill Therapeutics, Inc. | Methods and immune modulatory nucleic acid compositions for preventing and treating disease |
| LT2484375T (lt) | 2006-09-26 | 2018-07-10 | Infectious Disease Research Institute | Vakcinos kompozicija, turinti sintetinio adjuvanto |
| US20090181078A1 (en) | 2006-09-26 | 2009-07-16 | Infectious Disease Research Institute | Vaccine composition containing synthetic adjuvant |
| US20080260820A1 (en) | 2007-04-19 | 2008-10-23 | Gilles Borrelly | Oral dosage formulations of protease-resistant polypeptides |
| EP2152889B1 (en) | 2007-05-29 | 2017-03-15 | Nature Technology Corporation | Vectors and methods for genetic immunization |
| KR101351195B1 (ko) | 2007-07-27 | 2014-01-14 | 이매틱스 바이오테크놀로지스 게엠베하 | 면역 치료를 위한 새로운 면역원성 에피톱 |
| WO2009035554A2 (en) | 2007-09-07 | 2009-03-19 | University Of Florida Research Foundation, Inc. | Superior structure stability and selectivity of hairpin nucleic acid probes with an l-dna stem |
| RU2010112771A (ru) | 2007-10-09 | 2011-11-20 | Коули Фармасьютикал ГмбХ (DE) | Иммуностимулирующие аналоги олигонуклеотидов, содержащие модифицированные сахарные группировки |
| EP2058397A1 (de) | 2007-11-07 | 2009-05-13 | Mologen AG | Multimeres Assemblat zur Immunstimulation |
| WO2009069447A1 (ja) | 2007-11-28 | 2009-06-04 | Toray Industries, Inc. | インフルエンザワクチン用のアジュバント及びインフルエンザワクチン |
| WO2009069682A1 (ja) | 2007-11-28 | 2009-06-04 | Toray Industries, Inc. | 肝炎の治療剤又は予防剤 |
| WO2010039137A1 (en) | 2008-10-02 | 2010-04-08 | Idera Pharmaceuticals, Inc. | Immune regulatory oligonucleotide (iro) compounds to modulate toll-like receptor based immune response |
| EP2246433A1 (de) | 2009-04-30 | 2010-11-03 | Mologen AG | Concatemere zur Immunmodulation |
| AU2011231574A1 (en) | 2010-03-26 | 2012-10-11 | Glaxosmithkline Biologicals S.A. | HIV vaccine |
| GB201021873D0 (en) | 2010-12-23 | 2011-02-02 | Mologen Ag | DNA expression construct |
| GB201021867D0 (en) * | 2010-12-23 | 2011-02-02 | Mologen Ag | Non-coding immunomodulatory DNA construct |
| JP5761707B2 (ja) | 2011-02-02 | 2015-08-12 | 国立研究開発法人産業技術総合研究所 | 高効率細胞融合法 |
| AU2013278843A1 (en) * | 2012-06-21 | 2014-03-27 | Compugen Ltd. | LSR antibodies, and uses thereof for treatment of cancer |
| GB2514591A (en) | 2013-05-30 | 2014-12-03 | Mologen Ag | Predictive biomarker for cancer therapy |
| GB2523187A (en) * | 2014-02-18 | 2015-08-19 | Mologen Ag | Covalently closed non-coding immunomodulatory DNA construct |
| LU92821B1 (en) | 2015-09-09 | 2017-03-20 | Mologen Ag | Combination comprising immunostimulatory oligonucleotides |
| GB2542425A (en) | 2015-09-21 | 2017-03-22 | Mologen Ag | Means for the treatment of HIV |
| EP3392345A1 (en) | 2017-04-22 | 2018-10-24 | Mologen AG | Biomarker for small cell lung cancer therapy |
| WO2019043194A1 (en) | 2017-08-31 | 2019-03-07 | Mologen Ag | TLR-9 AGONISTS FOR TUMOR MICROENVIRONMENT MODULATION |
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