|
EP2734621B1
(en)
|
2011-07-22 |
2019-09-04 |
President and Fellows of Harvard College |
Evaluation and improvement of nuclease cleavage specificity
|
|
WO2014204578A1
(en)
|
2013-06-21 |
2014-12-24 |
The General Hospital Corporation |
Using rna-guided foki nucleases (rfns) to increase specificity for rna-guided genome editing
|
|
WO2015099850A1
(en)
*
|
2013-12-26 |
2015-07-02 |
The General Hospital Corporation |
Multiplex guide rnas
|
|
KR102405549B1
(ko)
|
2013-03-15 |
2022-06-08 |
더 제너럴 하스피탈 코포레이션 |
Rna-안내 게놈 편집을 위해 특이성을 증가시키기 위한 절단된 안내 rna(tru-grnas)의 이용
|
|
US10760064B2
(en)
|
2013-03-15 |
2020-09-01 |
The General Hospital Corporation |
RNA-guided targeting of genetic and epigenomic regulatory proteins to specific genomic loci
|
|
US20150044192A1
(en)
|
2013-08-09 |
2015-02-12 |
President And Fellows Of Harvard College |
Methods for identifying a target site of a cas9 nuclease
|
|
US9359599B2
(en)
|
2013-08-22 |
2016-06-07 |
President And Fellows Of Harvard College |
Engineered transcription activator-like effector (TALE) domains and uses thereof
|
|
US9340799B2
(en)
|
2013-09-06 |
2016-05-17 |
President And Fellows Of Harvard College |
MRNA-sensing switchable gRNAs
|
|
US9388430B2
(en)
|
2013-09-06 |
2016-07-12 |
President And Fellows Of Harvard College |
Cas9-recombinase fusion proteins and uses thereof
|
|
US9526784B2
(en)
|
2013-09-06 |
2016-12-27 |
President And Fellows Of Harvard College |
Delivery system for functional nucleases
|
|
US10584358B2
(en)
|
2013-10-30 |
2020-03-10 |
North Carolina State University |
Compositions and methods related to a type-II CRISPR-Cas system in Lactobacillus buchneri
|
|
ES2670983T3
(es)
|
2013-11-07 |
2018-06-04 |
Editas Medicine, Inc. |
Métodos y composiciones relacionados con CRISPR con ARNg rectores
|
|
US11053481B2
(en)
|
2013-12-12 |
2021-07-06 |
President And Fellows Of Harvard College |
Fusions of Cas9 domains and nucleic acid-editing domains
|
|
MX2016009243A
(es)
*
|
2014-01-14 |
2017-03-08 |
Lam Therapeutics Inc |
Métodos de mutagénesis.
|
|
US10787654B2
(en)
|
2014-01-24 |
2020-09-29 |
North Carolina State University |
Methods and compositions for sequence guiding Cas9 targeting
|
|
EP3129490A4
(en)
|
2014-04-08 |
2017-10-04 |
North Carolina State University |
Methods and compositions for rna-directed repression of transcription using crispr-associated genes
|
|
WO2016022363A2
(en)
|
2014-07-30 |
2016-02-11 |
President And Fellows Of Harvard College |
Cas9 proteins including ligand-dependent inteins
|
|
US10450584B2
(en)
|
2014-08-28 |
2019-10-22 |
North Carolina State University |
Cas9 proteins and guiding features for DNA targeting and genome editing
|
|
WO2016070037A2
(en)
*
|
2014-10-31 |
2016-05-06 |
Massachusetts Institute Of Technology |
Massively parallel combinatorial genetics for crispr
|
|
WO2016084084A1
(en)
*
|
2014-11-27 |
2016-06-02 |
Danziger Innovations Ltd. |
Nucleic acid constructs for genome editing
|
|
JP6529110B2
(ja)
*
|
2014-12-01 |
2019-06-12 |
国立大学法人 東京大学 |
複数のユニットが多重に連結したdnaカセットおよび該カセットを含むベクターの製造方法
|
|
EP3291679B1
(en)
|
2015-05-06 |
2021-12-15 |
SNIPR Technologies Limited |
Altering microbial populations & modifying microbiota
|
|
AU2016270649B2
(en)
|
2015-05-29 |
2022-04-21 |
North Carolina State University |
Methods for screening bacteria, archaea, algae, and yeast using crispr nucleic acids
|
|
KR102902492B1
(ko)
|
2015-06-15 |
2025-12-18 |
노쓰 캐롤라이나 스테이트 유니버시티 |
핵산 및 rna-기반 항미생물제를 효율적으로 전달하기 위한 방법 및 조성물
|
|
US9512446B1
(en)
|
2015-08-28 |
2016-12-06 |
The General Hospital Corporation |
Engineered CRISPR-Cas9 nucleases
|
|
US9926546B2
(en)
|
2015-08-28 |
2018-03-27 |
The General Hospital Corporation |
Engineered CRISPR-Cas9 nucleases
|
|
WO2017058751A1
(en)
|
2015-09-28 |
2017-04-06 |
North Carolina State University |
Methods and compositions for sequence specific antimicrobials
|
|
IL294014B2
(en)
|
2015-10-23 |
2024-07-01 |
Harvard College |
Nucleobase editors and uses thereof
|
|
DK3390632T3
(da)
*
|
2015-12-18 |
2025-12-01 |
Danisco Us Inc |
Fremgangsmåder og sammensætninger til polymerase ii (pol-ii)-baseret guide-rna-ekspression
|
|
US11542466B2
(en)
|
2015-12-22 |
2023-01-03 |
North Carolina State University |
Methods and compositions for delivery of CRISPR based antimicrobials
|
|
CN105543223A
(zh)
*
|
2015-12-25 |
2016-05-04 |
华侨大学 |
一种基于miRNA/shRNA转录加工机制转录sgRNA的方法
|
|
EP3199632A1
(en)
|
2016-01-26 |
2017-08-02 |
ACIB GmbH |
Temperature-inducible crispr/cas system
|
|
EP3219799A1
(en)
|
2016-03-17 |
2017-09-20 |
IMBA-Institut für Molekulare Biotechnologie GmbH |
Conditional crispr sgrna expression
|
|
EP3448996A1
(en)
|
2016-04-26 |
2019-03-06 |
Massachusetts Institute of Technology |
Extensible recombinase cascades
|
|
GB201609811D0
(en)
|
2016-06-05 |
2016-07-20 |
Snipr Technologies Ltd |
Methods, cells, systems, arrays, RNA and kits
|
|
US11293021B1
(en)
|
2016-06-23 |
2022-04-05 |
Inscripta, Inc. |
Automated cell processing methods, modules, instruments, and systems
|
|
US10450599B2
(en)
|
2016-07-05 |
2019-10-22 |
California Institute Of Technology |
Fractional initiator hybridization chain reaction
|
|
WO2018027078A1
(en)
|
2016-08-03 |
2018-02-08 |
President And Fellows Of Harard College |
Adenosine nucleobase editors and uses thereof
|
|
CN109804066A
(zh)
|
2016-08-09 |
2019-05-24 |
哈佛大学的校长及成员们 |
可编程cas9-重组酶融合蛋白及其用途
|
|
WO2018039438A1
(en)
|
2016-08-24 |
2018-03-01 |
President And Fellows Of Harvard College |
Incorporation of unnatural amino acids into proteins using base editing
|
|
IL264831B
(en)
|
2016-08-30 |
2022-09-01 |
California Inst Of Techn |
Immunohistochemistry via hybridization chain reaction
|
|
EP3510151B1
(en)
*
|
2016-09-09 |
2024-07-03 |
The Board of Trustees of the Leland Stanford Junior University |
High-throughput precision genome editing
|
|
CN110214180A
(zh)
|
2016-10-14 |
2019-09-06 |
哈佛大学的校长及成员们 |
核碱基编辑器的aav递送
|
|
US10745677B2
(en)
|
2016-12-23 |
2020-08-18 |
President And Fellows Of Harvard College |
Editing of CCR5 receptor gene to protect against HIV infection
|
|
EP3568476A1
(en)
*
|
2017-01-11 |
2019-11-20 |
Oxford University Innovation Limited |
Crispr rna
|
|
TW201839136A
(zh)
|
2017-02-06 |
2018-11-01 |
瑞士商諾華公司 |
治療血色素異常症之組合物及方法
|
|
WO2018165504A1
(en)
|
2017-03-09 |
2018-09-13 |
President And Fellows Of Harvard College |
Suppression of pain by gene editing
|
|
WO2018165631A1
(en)
|
2017-03-09 |
2018-09-13 |
President And Fellows Of Harvard College |
Cancer vaccine
|
|
JP2020510439A
(ja)
|
2017-03-10 |
2020-04-09 |
プレジデント アンド フェローズ オブ ハーバード カレッジ |
シトシンからグアニンへの塩基編集因子
|
|
US20200010519A1
(en)
|
2017-03-10 |
2020-01-09 |
Institut National De La Sante Et De La Recherche Medicale(Inserm) |
Nuclease fusions for enhancing genome editing by homology-directed transgene integration
|
|
KR20240116572A
(ko)
|
2017-03-23 |
2024-07-29 |
프레지던트 앤드 펠로우즈 오브 하바드 칼리지 |
핵산 프로그램가능한 dna 결합 단백질을 포함하는 핵염기 편집제
|
|
US11560566B2
(en)
|
2017-05-12 |
2023-01-24 |
President And Fellows Of Harvard College |
Aptazyme-embedded guide RNAs for use with CRISPR-Cas9 in genome editing and transcriptional activation
|
|
US20180362944A1
(en)
*
|
2017-06-12 |
2018-12-20 |
California Institute Of Technology |
CONDITIONAL GUIDE RNAs
|
|
US9982279B1
(en)
|
2017-06-23 |
2018-05-29 |
Inscripta, Inc. |
Nucleic acid-guided nucleases
|
|
US10011849B1
(en)
|
2017-06-23 |
2018-07-03 |
Inscripta, Inc. |
Nucleic acid-guided nucleases
|
|
AU2018291041B2
(en)
|
2017-06-30 |
2021-08-05 |
Inscripta, Inc. |
Automated cell processing methods, modules, instruments, and systems
|
|
WO2019017988A1
(en)
*
|
2017-07-21 |
2019-01-24 |
Arizona Board Of Regents On Behalf Of Arizona State University |
CRISPR FLUORESCENT GUIDED RNA (ARNFG) FOR UNDERSTANDING RNAs EXPRESSED FROM POL II PROMOTERS
|
|
CN111801345A
(zh)
|
2017-07-28 |
2020-10-20 |
哈佛大学的校长及成员们 |
使用噬菌体辅助连续进化(pace)的进化碱基编辑器的方法和组合物
|
|
US11319532B2
(en)
|
2017-08-30 |
2022-05-03 |
President And Fellows Of Harvard College |
High efficiency base editors comprising Gam
|
|
CN111373041B
(zh)
*
|
2017-09-26 |
2024-10-11 |
伊利诺伊大学理事会 |
用于基因组编辑和调节转录的crispr/cas系统和方法
|
|
CN111757937A
(zh)
|
2017-10-16 |
2020-10-09 |
布罗德研究所股份有限公司 |
腺苷碱基编辑器的用途
|
|
US12406749B2
(en)
|
2017-12-15 |
2025-09-02 |
The Broad Institute, Inc. |
Systems and methods for predicting repair outcomes in genetic engineering
|
|
CN111788307A
(zh)
*
|
2018-03-12 |
2020-10-16 |
南京北恒生物科技有限公司 |
工程化的嵌合向导rna及其用途
|
|
US10760075B2
(en)
|
2018-04-30 |
2020-09-01 |
Snipr Biome Aps |
Treating and preventing microbial infections
|
|
CN108330138B
(zh)
*
|
2018-03-29 |
2018-09-25 |
上海欣百诺生物科技有限公司 |
一种sgRNA的体外合成方法及其试剂盒
|
|
CN108728441B
(zh)
*
|
2018-04-18 |
2022-07-22 |
深圳市第二人民医院 |
特异性识别p53突变的基因系统
|
|
US10508273B2
(en)
|
2018-04-24 |
2019-12-17 |
Inscripta, Inc. |
Methods for identifying selective binding pairs
|
|
US10858761B2
(en)
|
2018-04-24 |
2020-12-08 |
Inscripta, Inc. |
Nucleic acid-guided editing of exogenous polynucleotides in heterologous cells
|
|
US10526598B2
(en)
|
2018-04-24 |
2020-01-07 |
Inscripta, Inc. |
Methods for identifying T-cell receptor antigens
|
|
US20210130832A1
(en)
*
|
2018-04-30 |
2021-05-06 |
Oregon Health & Science University |
Methods of gene therapy
|
|
WO2019226953A1
(en)
|
2018-05-23 |
2019-11-28 |
The Broad Institute, Inc. |
Base editors and uses thereof
|
|
AU2019292919A1
(en)
|
2018-06-30 |
2021-03-11 |
Inscripta, Inc. |
Instruments, modules, and methods for improved detection of edited sequences in live cells
|
|
EP3820495A4
(en)
|
2018-07-09 |
2022-07-20 |
The Broad Institute Inc. |
RNA-PROGRAMMABLE EPIGENETIC RNA MODIFIERS AND THEIR USES
|
|
US11142740B2
(en)
|
2018-08-14 |
2021-10-12 |
Inscripta, Inc. |
Detection of nuclease edited sequences in automated modules and instruments
|
|
US12264330B2
(en)
|
2018-10-01 |
2025-04-01 |
North Carolina State University |
Recombinant type I CRISPR-Cas system and uses thereof for killing target cells
|
|
US12264313B2
(en)
|
2018-10-01 |
2025-04-01 |
North Carolina State University |
Recombinant type I CRISPR-Cas system and uses thereof for genome modification and alteration of expression
|
|
US12203123B2
(en)
|
2018-10-01 |
2025-01-21 |
North Carolina State University |
Recombinant type I CRISPR-Cas system and uses thereof for screening for variant cells
|
|
WO2020072248A1
(en)
|
2018-10-01 |
2020-04-09 |
North Carolina State University |
Recombinant type i crispr-cas system
|
|
US11851663B2
(en)
|
2018-10-14 |
2023-12-26 |
Snipr Biome Aps |
Single-vector type I vectors
|
|
GB201817010D0
(en)
*
|
2018-10-18 |
2018-12-05 |
Imperial Innovations Ltd |
Methods
|
|
US11214781B2
(en)
|
2018-10-22 |
2022-01-04 |
Inscripta, Inc. |
Engineered enzyme
|
|
CN113227368B
(zh)
|
2018-10-22 |
2023-07-07 |
因思科瑞普特公司 |
工程化酶
|
|
US12281338B2
(en)
|
2018-10-29 |
2025-04-22 |
The Broad Institute, Inc. |
Nucleobase editors comprising GeoCas9 and uses thereof
|
|
US20220056460A1
(en)
*
|
2018-12-05 |
2022-02-24 |
Dsm Ip Assets B.V. |
Crispr guide-rna expression strategies for multiplex genome engineering
|
|
WO2020131986A1
(en)
*
|
2018-12-21 |
2020-06-25 |
Pioneer Hi-Bred International, Inc. |
Multiplex genome targeting
|
|
US12351837B2
(en)
|
2019-01-23 |
2025-07-08 |
The Broad Institute, Inc. |
Supernegatively charged proteins and uses thereof
|
|
CA3130488A1
(en)
|
2019-03-19 |
2020-09-24 |
David R. Liu |
Methods and compositions for editing nucleotide sequences
|
|
EP3947691A4
(en)
|
2019-03-25 |
2022-12-14 |
Inscripta, Inc. |
SIMULTANEOUS MULTIPLEX GENOME EDITING IN A YEAST
|
|
US11001831B2
(en)
|
2019-03-25 |
2021-05-11 |
Inscripta, Inc. |
Simultaneous multiplex genome editing in yeast
|
|
US12473543B2
(en)
|
2019-04-17 |
2025-11-18 |
The Broad Institute, Inc. |
Adenine base editors with reduced off-target effects
|
|
CA3139122C
(en)
|
2019-06-06 |
2023-04-25 |
Inscripta, Inc. |
Curing for recursive nucleic acid-guided cell editing
|
|
EP3986909A4
(en)
|
2019-06-21 |
2023-08-02 |
Inscripta, Inc. |
Genome-wide rationally-designed mutations leading to enhanced lysine production in e. coli
|
|
US10927385B2
(en)
|
2019-06-25 |
2021-02-23 |
Inscripta, Inc. |
Increased nucleic-acid guided cell editing in yeast
|
|
US12435330B2
(en)
|
2019-10-10 |
2025-10-07 |
The Broad Institute, Inc. |
Methods and compositions for prime editing RNA
|
|
WO2021102059A1
(en)
|
2019-11-19 |
2021-05-27 |
Inscripta, Inc. |
Methods for increasing observed editing in bacteria
|
|
KR102776469B1
(ko)
|
2019-12-10 |
2025-03-05 |
인스크립타 인코포레이티드 |
신규 mad 뉴클레아제
|
|
CN114829607A
(zh)
|
2019-12-18 |
2022-07-29 |
因思科瑞普特公司 |
用于体内检测核酸引导的核酸酶编辑的细胞的Cascade/dCas3互补测定
|
|
KR20220133257A
(ko)
|
2020-01-27 |
2022-10-04 |
인스크립타 인코포레이티드 |
전기천공 모듈 및 기구
|
|
EP3889259A1
(en)
|
2020-03-30 |
2021-10-06 |
IMBA-Institut für Molekulare Biotechnologie GmbH |
Internal standard for crispr guide rna
|
|
US20210332388A1
(en)
|
2020-04-24 |
2021-10-28 |
Inscripta, Inc. |
Compositions, methods, modules and instruments for automated nucleic acid-guided nuclease editing in mammalian cells
|
|
WO2021226558A1
(en)
|
2020-05-08 |
2021-11-11 |
The Broad Institute, Inc. |
Methods and compositions for simultaneous editing of both strands of a target double-stranded nucleotide sequence
|
|
US11787841B2
(en)
|
2020-05-19 |
2023-10-17 |
Inscripta, Inc. |
Rationally-designed mutations to the thrA gene for enhanced lysine production in E. coli
|
|
GB202007943D0
(en)
|
2020-05-27 |
2020-07-08 |
Snipr Biome Aps |
Products & methods
|
|
CN111850011B
(zh)
*
|
2020-06-24 |
2022-08-26 |
湖南文理学院 |
改良的Csy4序列、改良方法及应用
|
|
CN116322789A
(zh)
*
|
2020-06-30 |
2023-06-23 |
爱丁堡大学理事会 |
转基因表达系统
|
|
EP4214314A4
(en)
|
2020-09-15 |
2024-10-16 |
Inscripta, Inc. |
Crispr editing to embed nucleic acid landing pads into genomes of live cells
|
|
US11512297B2
(en)
|
2020-11-09 |
2022-11-29 |
Inscripta, Inc. |
Affinity tag for recombination protein recruitment
|
|
US11306298B1
(en)
|
2021-01-04 |
2022-04-19 |
Inscripta, Inc. |
Mad nucleases
|
|
US11332742B1
(en)
|
2021-01-07 |
2022-05-17 |
Inscripta, Inc. |
Mad nucleases
|
|
WO2022164796A1
(en)
|
2021-01-26 |
2022-08-04 |
California Institute Of Technology |
Allosteric conditional guide rnas for cell-selective regulation of crispr/cas
|
|
US11884924B2
(en)
|
2021-02-16 |
2024-01-30 |
Inscripta, Inc. |
Dual strand nucleic acid-guided nickase editing
|
|
WO2022204088A1
(en)
*
|
2021-03-22 |
2022-09-29 |
Massachusetts Institute Of Technology |
Multi-input mirna sensing with constitutive erns to regulate multi-output gene expression in mammalian cells
|
|
EP4326863A4
(en)
*
|
2021-04-20 |
2025-04-23 |
Texas Tech University System |
Tissue culture-independent gene editing of cells using a long-distance RNA delivery system
|
|
CN115704040A
(zh)
*
|
2021-08-06 |
2023-02-17 |
华东理工大学 |
基于CRISPRi和CRISPRa的转录调控系统、其建立方法及应用
|
|
WO2023018938A1
(en)
*
|
2021-08-12 |
2023-02-16 |
The J. David Gladstone Institutes, A Testamentary Trust Established Under The Will Of J. David Gladstone |
Methods for generation of precise rna transcripts
|
|
CN113604472B
(zh)
*
|
2021-09-17 |
2024-01-09 |
中国科学院植物研究所 |
一种应用于里氏木霉的CRISPR/Cas基因编辑系统
|
|
GB202209518D0
(en)
|
2022-06-29 |
2022-08-10 |
Snipr Biome Aps |
Treating & preventing E coli infections
|
|
WO2025165779A1
(en)
*
|
2024-02-01 |
2025-08-07 |
The Board Of Trustees Of The Leland Stanford Junior University |
Simultaneous gene knockin and knockout in engineered cell therapies with mrna expressed guide rnas
|
|
CN119220682B
(zh)
*
|
2024-10-25 |
2025-04-22 |
首都医科大学附属北京儿童医院 |
Saal1作为神经母细胞瘤预后评估标志物和药物靶点的应用
|