JP2008522585A5 - - Google Patents

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Publication number
JP2008522585A5
JP2008522585A5 JP2007536777A JP2007536777A JP2008522585A5 JP 2008522585 A5 JP2008522585 A5 JP 2008522585A5 JP 2007536777 A JP2007536777 A JP 2007536777A JP 2007536777 A JP2007536777 A JP 2007536777A JP 2008522585 A5 JP2008522585 A5 JP 2008522585A5
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JP
Japan
Prior art keywords
mirna
target sequence
nucleic acid
modified
plant
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
JP2007536777A
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English (en)
Japanese (ja)
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JP2008522585A (ja
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Priority claimed from PCT/US2005/036373 external-priority patent/WO2006044322A2/en
Publication of JP2008522585A publication Critical patent/JP2008522585A/ja
Publication of JP2008522585A5 publication Critical patent/JP2008522585A5/ja
Withdrawn legal-status Critical Current

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JP2007536777A 2004-10-12 2005-10-12 マイクロｒｎａ Withdrawn JP2008522585A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
USPCT/US04/33379 2004-10-12
US67108905P 2005-04-14 2005-04-14
PCT/US2005/036373 WO2006044322A2 (en) 2004-10-12 2005-10-12 Micrornas

Publications (2)

Publication Number Publication Date
JP2008522585A JP2008522585A (ja) 2008-07-03
JP2008522585A5 true JP2008522585A5 (enExample) 2008-11-20

Family

ID=36203437

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2007536777A Withdrawn JP2008522585A (ja) 2004-10-12 2005-10-12 マイクロｒｎａ

Country Status (10)

Country Link
US (2) US8975471B2 (enExample)
EP (1) EP1809748B1 (enExample)
JP (1) JP2008522585A (enExample)
CN (1) CN101076592B (enExample)
AR (1) AR050972A1 (enExample)
AU (1) AU2005295948A1 (enExample)
BR (1) BRPI0516874A (enExample)
CA (1) CA2583690C (enExample)
MX (1) MX2007004321A (enExample)
WO (1) WO2006044322A2 (enExample)

Families Citing this family (48)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8237017B2 (en) 2006-05-12 2012-08-07 Bayer Cropscience Nv Stress-related microRNA molecules and uses thereof
AU2007290367B2 (en) 2006-08-31 2013-10-31 Monsanto Technology, Llc Phased small RNAs
US20080081330A1 (en) * 2006-09-28 2008-04-03 Helicos Biosciences Corporation Method and devices for analyzing small RNA molecules
US20080189805A1 (en) * 2006-12-13 2008-08-07 Serbin John J Novel genes and rna molecules that confer stress tolerance
WO2008083969A2 (en) 2007-01-11 2008-07-17 Bayer Bioscience N.V. Differential expression of subgenome specific alleles in cotton and uses thereof
CA2675954A1 (en) * 2007-01-18 2008-07-24 Plant Bioscience Limited (Pbl) Methods and compositions for modulating the mirna pathway
CN101646769A (zh) 2007-02-20 2010-02-10 孟山都技术公司 无脊椎动物微rna
US20080313773A1 (en) * 2007-05-14 2008-12-18 The Rockefeller University Production of artificial micrornas using synthetic microrna precursors
CA2691617C (en) 2007-05-31 2020-07-21 University Of Iowa Research Foundation Reduction of off-target rna interference toxicity
US20100292099A1 (en) * 2007-08-23 2010-11-18 Keren Pharmaceutical, Inc. Targeting of rna with external guide sequences
US8115055B2 (en) * 2007-12-18 2012-02-14 E.I. Du Pont De Nemours And Company Down-regulation of gene expression using artificial microRNAs
WO2009111587A2 (en) 2008-03-04 2009-09-11 Washington State University Compositions and methods for differential regulation of fatty acid unsaturation in membrane lipids and seed oil
MX349774B (es) 2008-05-26 2017-08-10 Bayer Cropscience Nv Metodos y medios para modificar la resistencia de las fibras en plantas que producen fibras.
WO2010042575A1 (en) * 2008-10-08 2010-04-15 Monsanto Technology Llc Transgenic plants with enhanced agronomic traits
US8309530B2 (en) 2009-02-04 2012-11-13 Washington State University Compositions and methods for modulating ghrelin-mediated conditions
CN107129998A (zh) 2009-06-10 2017-09-05 淡马锡生命科学研究院有限公司 用于棉花中基因功能性分析的病毒诱导的基因沉默(vigs)
CN101710362B (zh) * 2009-12-10 2011-07-20 浙江大学 一种基于支持向量机的microRNA靶位点预测的方法
WO2012001626A1 (en) * 2010-06-30 2012-01-05 Basf Plant Science Company Gmbh Novel microrna precursor and use thereof in regulation of target gene expression
CN101976296B (zh) * 2010-09-10 2012-05-23 浙江大学 结合基于下一代测序数据的植物microRNA靶位互作网络预测的方法
CN103270158A (zh) * 2010-10-15 2013-08-28 昆士兰大学 小的病毒rna分子及其用途
WO2012109667A1 (en) 2011-02-12 2012-08-16 University Of Iowa Research Foundation Therapeutic compounds
UY33992A (es) * 2011-04-21 2012-09-28 Basf Plant Science Co Gmbh Métodos para modificar la biosintesis de la lignina y mejorar la digestibilidad
BR112014018009A2 (pt) * 2012-01-23 2018-06-26 Du Pont sequência de ácido nucleico isolada, construção recombinante, célula vegetal, método para reduzir a expressão de pelo menos um gene biossintético de ácido graxo vegetal, método para reduzir a expressão de dois ou mais genes biossintéticos de ácido graxo vegetal e planta ou semente transgênica
EP2825209B1 (en) 2012-03-14 2018-08-29 University of Central Florida Research Foundation, Inc. Neurofibromatoses therapeutic agents and screening for same
EP2839007B1 (en) 2012-04-19 2017-12-27 Temasek Life Sciences Laboratory Limited Methods for increasing cotton fiber length
CN102703500B (zh) * 2012-05-30 2014-03-12 清华大学 利用植物病毒载体进行miRNA靶标模拟序列构建和表达的方法
US20140030792A1 (en) * 2012-07-23 2014-01-30 Radhakrishnan Rathnachalam Therapeutic Anti-Virus VLPS
WO2014064704A2 (en) * 2012-10-28 2014-05-01 A.B. Seeds Ltd. Transgenic plants with modified sugar content and methods of generating same
CN103088061B (zh) * 2013-01-15 2016-08-03 中国科学院微生物研究所 一种rna及载体在制备预防和/或治疗肝癌产品中的应用
EP3088524A4 (en) 2013-12-26 2017-08-09 Tokyo Medical University Artificial mimic mirna for controlling gene expression, and use of same
CA2935022A1 (en) 2013-12-27 2015-07-02 Bonac Corporation Artificial match-type mirna for controlling gene expression and use therefor
US9523093B2 (en) 2014-05-20 2016-12-20 University Of Iowa Research Foundation Huntington's disease therapeutic compounds
WO2016038511A1 (en) * 2014-09-10 2016-03-17 The New Zealand Institute For Plant And Food Research Limited Methods and materials for producing fruit of altered size
WO2016061232A2 (en) * 2014-10-14 2016-04-21 Texas Tech University System Multiplexed shrnas and uses thereof
CN107002062A (zh) 2014-10-22 2017-08-01 淡马锡生命科学研究院有限公司 来自依兰fruticosa 变种(Cananga odorata var. fruticosa)的萜烯合酶
AU2015368293B2 (en) 2014-12-27 2021-07-22 Bonac Corporation Naturally occuring miRNA for controlling gene expression, and use of same
CN104774837B (zh) * 2015-03-13 2018-02-02 浙江省医学科学院 9种植物微小核糖核苷酸及其应用
EP3276003B1 (en) 2015-03-27 2022-07-20 Bonac Corporation Single-chain nucleic acid molecule having delivery function and gene expression control ability
CN106167801B (zh) * 2016-09-30 2018-08-28 山东大学 大豆威廉姆斯82中NAC膜结合转录因子基因GmNTL1及其应用
KR102138495B1 (ko) * 2017-11-27 2020-07-28 (주)프로스테믹스 이중 가닥의 올리고뉴클레오티드 및 그 제조 방법
CN111621588A (zh) * 2020-06-08 2020-09-04 华中农业大学 光亮果皮番茄品种选育的分子标记及其应用
CN112210555B (zh) * 2020-09-18 2022-02-22 大连理工大学 番茄抗晚疫病基因Sly-miR166b及其克隆方法与应用方法
CN114908089B (zh) * 2021-02-08 2024-03-15 上海细胞治疗集团有限公司 3’utr的构建方法和应用
CN114606236B (zh) * 2022-04-21 2024-01-05 南通大学 一种翘芪复方中药汤剂来源的微小核糖核酸及其制备方法和应用
CN115083516B (zh) * 2022-07-13 2023-03-21 北京先声医学检验实验室有限公司 一种基于靶向RNA测序技术检测基因融合的Panel设计和评估方法
CN117210463B (zh) * 2023-09-12 2024-03-19 扬州大学 一种与莲藕根状茎淀粉合成相关的miRNA及其应用
CN118516400B (zh) * 2024-07-24 2024-10-29 吉林农业大学 gma-miR169c基因在调控植物脂肪酸合成中的应用
CN120648688B (zh) * 2025-08-21 2025-11-07 中国农业科学院烟草研究所(中国烟草总公司青州烟草研究所) 与植物抗病毒相关的miR159a及其在提高植物对病毒抗性中的应用

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6506559B1 (en) 1997-12-23 2003-01-14 Carnegie Institute Of Washington Genetic inhibition by double-stranded RNA
DK1068311T3 (da) 1998-04-08 2011-08-08 Commw Scient Ind Res Org Fremgangsmåder og midler til opnåelse af modificerede fænotyper
HK1047109A1 (zh) 1999-10-15 2003-02-07 University Of Massachusetts 作为指定基因干预工具的rna干预轨迹基因
WO2003070918A2 (en) 2002-02-20 2003-08-28 Ribozyme Pharmaceuticals, Incorporated Rna interference by modified short interfering nucleic acid
DK2796553T3 (da) 2000-03-30 2019-09-30 Whitehead Inst Biomedical Res Rna-sekvensspecifikke formidlere af rna-interferens
EP1412371B1 (en) 2001-07-12 2016-02-24 University of Massachusetts IN VIVO PRODUCTION OF SMALL INTERFERING RNAs THAT MEDIATE GENE SILENCING
WO2003012052A2 (en) 2001-07-30 2003-02-13 The Government Of The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services Specific inhibition of gene expression by small double stranded rnas
US7166771B2 (en) 2002-06-21 2007-01-23 Monsanto Technology Llc Coordinated decrease and increase of gene expression of more than one gene using transgenic constructs
PT1504126E (pt) 2002-05-03 2014-06-02 Univ Duke Um método para regular a expressão génica
WO2004005485A2 (en) 2002-07-10 2004-01-15 Kansas State University Research Foundation Compositions and methods for controlling parasitic nematodes
CA2492917C (en) * 2002-07-19 2011-10-18 University Of South Carolina Compositions and methods for the modulation of gene expression in plants
WO2004066183A2 (en) 2003-01-22 2004-08-05 European Molecular Biology Laboratory Microrna
US7750144B2 (en) 2003-06-02 2010-07-06 University Of Massachusetts Methods and compositions for enhancing the efficacy and specificity of RNA silencing
PT1633767T (pt) 2003-06-02 2019-02-27 Univ Massachusetts Métodos e composições para controlar a eficácia do silenciamento de arn
AU2004252442B2 (en) 2003-06-02 2010-04-08 University Of Massachusetts Methods and compositions for enhancing the efficacy and specificity of FNAi
US20050144669A1 (en) 2003-07-01 2005-06-30 Whitehead Institute For Biomedical Research MicroRNAs in plants
US7071380B1 (en) * 2003-08-29 2006-07-04 Agrigenesis Biosciences Limited Control of floral induction
AU2004280634A1 (en) 2003-10-09 2005-04-21 E. I. Du Pont De Nemours And Company Gene silencing by using micro-RNA molecules

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