JP2012136542A5 - - Google Patents

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Publication number
JP2012136542A5
JP2012136542A5 JP2012045015A JP2012045015A JP2012136542A5 JP 2012136542 A5 JP2012136542 A5 JP 2012136542A5 JP 2012045015 A JP2012045015 A JP 2012045015A JP 2012045015 A JP2012045015 A JP 2012045015A JP 2012136542 A5 JP2012136542 A5 JP 2012136542A5
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JP
Japan
Prior art keywords
seq
rna molecule
sequence
composition
molecule
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Application number
JP2012045015A
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English (en)
Japanese (ja)
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JP2012136542A (ja
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Publication of JP2012136542A publication Critical patent/JP2012136542A/ja
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JP2012045015A 2004-09-10 2012-03-01 ウィルス遺伝子発現を効率的に阻害する低分子干渉ｒｎａおよびその使用方法 Pending JP2012136542A (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US60857404P 2004-09-10 2004-09-10
US60/608,574 2004-09-10

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
JP2007531467A Division JP2008512500A (ja) 2004-09-10 2005-09-12 ウィルス遺伝子発現を効率的に阻害する低分子干渉ｒｎａおよびその使用方法

Publications (2)

Publication Number Publication Date
JP2012136542A JP2012136542A (ja) 2012-07-19
JP2012136542A5 true JP2012136542A5 (enExample) 2013-05-30

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ID=36060681

Family Applications (2)

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JP2007531467A Withdrawn JP2008512500A (ja) 2004-09-10 2005-09-12 ウィルス遺伝子発現を効率的に阻害する低分子干渉ｒｎａおよびその使用方法
JP2012045015A Pending JP2012136542A (ja) 2004-09-10 2012-03-01 ウィルス遺伝子発現を効率的に阻害する低分子干渉ｒｎａおよびその使用方法

Family Applications Before (1)

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JP2007531467A Withdrawn JP2008512500A (ja) 2004-09-10 2005-09-12 ウィルス遺伝子発現を効率的に阻害する低分子干渉ｒｎａおよびその使用方法

Country Status (5)

Country Link
US (4) US20090170794A1 (enExample)
EP (1) EP1793835A4 (enExample)
JP (2) JP2008512500A (enExample)
IL (1) IL190114A0 (enExample)
WO (1) WO2006031901A2 (enExample)

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EP2114416B1 (en) * 2007-01-16 2015-08-05 The University Of Queensland Method of inducing an immune response
DK2308514T3 (da) 2007-03-23 2013-09-02 To Bbb Holding B V Konjugater til målrettet lægemiddeltransport gennem blod-hjerne barrieren
JP5149528B2 (ja) * 2007-03-30 2013-02-20 学校法人東京医科大学 Ｃ型肝炎ウイルスの複製を制御するマイクロｒｎａ
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CN102245772A (zh) 2008-10-15 2011-11-16 索马根尼科斯公司 抑制基因表达的短发卡rna
CN102325534B (zh) * 2008-12-18 2016-02-17 戴瑟纳制药公司 延长的dicer酶底物和特异性抑制基因表达的方法
JP2012529892A (ja) * 2009-06-19 2012-11-29 コモンウェルス サイエンティフィック アンド インダストリアル リサーチ オーガニゼーション ウイルス・アッセイ
JP5766188B2 (ja) 2009-07-01 2015-08-19 プロチバ バイオセラピューティクス インコーポレイティッド 固形腫瘍に治療剤を送達するための脂質製剤
EP2454371B1 (en) 2009-07-13 2021-01-20 Somagenics, Inc. Chemical modification of small hairpin rnas for inhibition of gene expression
ES2699630T3 (es) 2010-04-23 2019-02-12 Cold Spring Harbor Laboratory Novedosos ARNhc diseñados estructuralmente
WO2012053741A2 (ko) * 2010-10-22 2012-04-26 성균관대학교산학협력단 Rna 간섭을 유도하는 핵산 분자 및 그 용도
US20120308642A1 (en) * 2011-05-27 2012-12-06 Xavier University Of Louisiana Inhibiting hepatitis c viral replication with sirna combinations
EP2774989B1 (en) 2011-11-02 2018-09-05 Osaka City University Double-stranded nucleic acid molecule for gene expression control
NZ700075A (en) 2012-02-24 2016-05-27 Protiva Biotherapeutics Inc Trialkyl cationic lipids and methods of use thereof
US10125362B2 (en) 2012-05-22 2018-11-13 Olix Pharmaceuticals, Inc. RNA-interference-inducing nucleic acid molecule able to penetrate into cells, and use therefor
US10695548B1 (en) * 2013-02-14 2020-06-30 Transderm, Inc. Gene silencing in skin using self-delivery siRNA delivered by a meso device
JP6426268B2 (ja) * 2014-04-04 2018-11-21 バイオニア コーポレーションＢｉｏｎｅｅｒ Ｃｏｒｐｏｒａｔｉｏｎ 新規の二重らせんオリゴｒｎａおよびこれを含む線維症または呼吸器疾患の予防または治療用薬学組成物
CN108699556B (zh) 2015-11-16 2023-02-17 奥利克斯医药有限公司 使用靶向myd88或tlr3的rna复合物治疗老年性黄斑变性
CA3022874A1 (en) 2016-02-02 2017-08-10 Olix Pharmaceuticals, Inc. Treatment of atopic dermatitis and asthma using rna complexes that target il4ra, trpa1, or f2rl1
CN108779464B (zh) 2016-02-02 2022-05-17 奥利克斯医药有限公司 使用靶向angpt2和pdgfb的rna复合物治疗血管生成相关性疾病
CN109072238B (zh) 2016-04-11 2022-05-24 奥利克斯医药有限公司 使用靶向结缔组织生长因子的rna复合物治疗特发性肺纤维化
KR101916652B1 (ko) 2016-06-29 2018-11-08 올릭스 주식회사 작은 간섭 rna의 rna 간섭효과 증진용 화합물 및 이의 용도
WO2018146557A2 (en) 2017-02-10 2018-08-16 Dong Ki Lee Long double-stranded rna for rna interference
US20230150926A1 (en) 2020-03-17 2023-05-18 Genevant Sciences Gmbh Cationic lipids for lipid nanoparticle delivery of therapeutics to hepatic stellate cells
KR20230122081A (ko) 2020-12-18 2023-08-22 제네반트 사이언시즈 게엠베하 Peg 지질 및 지질 나노입자
US20250332112A1 (en) 2022-01-31 2025-10-30 Genevant Sciences Gmbh Ionizable cationic lipids for lipid nanoparticles
WO2025052278A1 (en) 2023-09-05 2025-03-13 Genevant Sciences Gmbh Pyrrolidine based cationic lipids for lipid nanoparticle delivery of therapeutics to hepatic stellate cells
WO2025133951A1 (en) 2023-12-21 2025-06-26 Genevant Sciences Gmbh Ionizable lipids suitable for lipid nanoparticles
WO2026022677A1 (en) 2024-07-22 2026-01-29 Genevant Sciences Gmbh Permanently charged cationic lipids
WO2026022656A2 (en) 2024-07-22 2026-01-29 Genevant Sciences Gmbh Lipid particle formulations with permanently charged cationic lipids

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