JP2012136542A5 - - Google Patents
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- Publication number
- JP2012136542A5 JP2012136542A5 JP2012045015A JP2012045015A JP2012136542A5 JP 2012136542 A5 JP2012136542 A5 JP 2012136542A5 JP 2012045015 A JP2012045015 A JP 2012045015A JP 2012045015 A JP2012045015 A JP 2012045015A JP 2012136542 A5 JP2012136542 A5 JP 2012136542A5
- Authority
- JP
- Japan
- Prior art keywords
- seq
- rna molecule
- sequence
- composition
- molecule
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 108091032973 (ribonucleotides)n+m Proteins 0.000 claims 9
- 241000711549 Hepacivirus C Species 0.000 claims 5
- 125000003729 nucleotide group Chemical group 0.000 claims 5
- 239000002773 nucleotide Substances 0.000 claims 4
- 108020004459 Small interfering RNA Proteins 0.000 claims 2
- 230000000692 anti-sense effect Effects 0.000 claims 2
- 239000004055 small Interfering RNA Substances 0.000 claims 2
- 108020004414 DNA Proteins 0.000 claims 1
- 102000053602 DNA Human genes 0.000 claims 1
- 108091027967 Small hairpin RNA Proteins 0.000 claims 1
- 230000014509 gene expression Effects 0.000 claims 1
- 208000010710 hepatitis C virus infection Diseases 0.000 claims 1
- 230000002401 inhibitory effect Effects 0.000 claims 1
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
- 230000010076 replication Effects 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US60857404P | 2004-09-10 | 2004-09-10 | |
| US60/608,574 | 2004-09-10 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2007531467A Division JP2008512500A (ja) | 2004-09-10 | 2005-09-12 | ウィルス遺伝子発現を効率的に阻害する低分子干渉ｒｎａおよびその使用方法 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2012136542A JP2012136542A (ja) | 2012-07-19 |
| JP2012136542A5 true JP2012136542A5 (enExample) | 2013-05-30 |
Family
ID=36060681
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2007531467A Withdrawn JP2008512500A (ja) | 2004-09-10 | 2005-09-12 | ウィルス遺伝子発現を効率的に阻害する低分子干渉ｒｎａおよびその使用方法 |
| JP2012045015A Pending JP2012136542A (ja) | 2004-09-10 | 2012-03-01 | ウィルス遺伝子発現を効率的に阻害する低分子干渉ｒｎａおよびその使用方法 |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2007531467A Withdrawn JP2008512500A (ja) | 2004-09-10 | 2005-09-12 | ウィルス遺伝子発現を効率的に阻害する低分子干渉ｒｎａおよびその使用方法 |
Country Status (5)
| Country | Link |
|---|---|
| US (4) | US20090170794A1 (enExample) |
| EP (1) | EP1793835A4 (enExample) |
| JP (2) | JP2008512500A (enExample) |
| IL (1) | IL190114A0 (enExample) |
| WO (1) | WO2006031901A2 (enExample) |
Families Citing this family (32)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20090170794A1 (en) | 2004-09-10 | 2009-07-02 | Somagenics Inc. | Small interfering rnas that efficiently inhibit viral expression and methods of use thereof |
| EP1849865B1 (en) * | 2005-01-28 | 2013-05-22 | Haplopharma Inc. | RNAi MEDICINE HAVING NO ADVERSE EFFECTS |
| KR20090003147A (ko) * | 2005-09-12 | 2009-01-09 | 소마제닉스 인코포레이티드 | 소형 간섭 ｒｎａ를 이용한 바이러스 유전자 발현의 억제 |
| CA2925983A1 (en) * | 2007-01-16 | 2008-07-24 | The University Of Queensland | Method of inducing an immune response |
| DK2308514T3 (da) | 2007-03-23 | 2013-09-02 | To Bbb Holding B V | Konjugater til målrettet lægemiddeltransport gennem blod-hjerne barrieren |
| JP5149528B2 (ja) * | 2007-03-30 | 2013-02-20 | 学校法人東京医科大学 | Ｃ型肝炎ウイルスの複製を制御するマイクロｒｎａ |
| WO2009127060A1 (en) | 2008-04-15 | 2009-10-22 | Protiva Biotherapeutics, Inc. | Novel lipid formulations for nucleic acid delivery |
| WO2010030396A2 (en) * | 2008-09-15 | 2010-03-18 | Stanford University | Novel shrna gene therapy for treatment of ischemic heart disease |
| WO2010045384A2 (en) | 2008-10-15 | 2010-04-22 | Somagenics Inc. | Short hairpin rnas for inhibition of gene expression |
| EP2379083B1 (en) * | 2008-12-18 | 2017-08-16 | Dicerna Pharmaceuticals, Inc. | Extended dicer substrate agents and methods for the specific inhibition of gene expression |
| WO2010144965A1 (en) * | 2009-06-19 | 2010-12-23 | Commonwealth Scientific And Industrial Research Organisation | Viral assay |
| ES2613498T3 (es) | 2009-07-01 | 2017-05-24 | Protiva Biotherapeutics Inc. | Nuevas formulaciones de lípidos para el suministro de agentes terapéuticos a tumores sólidos |
| EP2454371B1 (en) | 2009-07-13 | 2021-01-20 | Somagenics, Inc. | Chemical modification of small hairpin rnas for inhibition of gene expression |
| SMT201800691T1 (it) | 2010-04-23 | 2019-01-11 | Cold Spring Harbor Laboratory | Shrna progettati strutturalmente innovativi |
| ES2732929T3 (es) * | 2010-10-22 | 2019-11-26 | Olix Pharmaceuticals Inc | Moléculas de ácido nucleico que inducen interferencia de ARN y usos de las mismas |
| US20120308642A1 (en) * | 2011-05-27 | 2012-12-06 | Xavier University Of Louisiana | Inhibiting hepatitis c viral replication with sirna combinations |
| WO2013065791A1 (ja) * | 2011-11-02 | 2013-05-10 | 公立大学法人大阪市立大学 | 遺伝子発現抑制用二本鎖核酸分子 |
| AU2013222179B2 (en) | 2012-02-24 | 2017-08-24 | Arbutus Biopharma Corporat ion | Trialkyl cationic lipids and methods of use thereof |
| CN104755620B (zh) | 2012-05-22 | 2018-03-02 | 奥利克斯医药有限公司 | 具有细胞内穿透能力的诱导rna干扰的核酸分子及其用途 |
| US10695548B1 (en) * | 2013-02-14 | 2020-06-30 | Transderm, Inc. | Gene silencing in skin using self-delivery siRNA delivered by a meso device |
| ES2984979T3 (es) * | 2014-04-04 | 2024-10-31 | Bioneer Corp | Oligo ARN de doble cadena y composición farmacéutica que comprende el mismo para la prevención o tratamiento de fibrosis o enfermedades respiratorias |
| JP7027311B2 (ja) | 2015-11-16 | 2022-03-01 | オリックス ファーマシューティカルズ，インコーポレーテッド | ＭｙＤ８８又はＴＬＲ３を標的とするＲＮＡ複合体を使用した加齢黄斑変性の治療 |
| WO2017134526A1 (en) | 2016-02-02 | 2017-08-10 | Olix Pharmaceuticals, Inc. | Treatment of angiogenesis-associated diseases using rna complexes that target angpt2 and pdgfb |
| CN108779463B (zh) | 2016-02-02 | 2022-05-24 | 奥利克斯医药有限公司 | 使用靶向IL4Rα、TRPA1或F2RL1的RNA复合物治疗特应性皮炎和哮喘 |
| US10301628B2 (en) | 2016-04-11 | 2019-05-28 | Olix Pharmaceuticals, Inc. | Treatment of idiopathic pulmonary fibrosis using RNA complexes that target connective tissue growth factor |
| KR101916652B1 (ko) | 2016-06-29 | 2018-11-08 | 올릭스 주식회사 | 작은 간섭 rna의 rna 간섭효과 증진용 화합물 및 이의 용도 |
| KR20190108167A (ko) | 2017-02-10 | 2019-09-23 | 성균관대학교산학협력단 | Rna 간섭을 위한 긴 이중가닥 rna |
| US20230150926A1 (en) | 2020-03-17 | 2023-05-18 | Genevant Sciences Gmbh | Cationic lipids for lipid nanoparticle delivery of therapeutics to hepatic stellate cells |
| WO2022133344A1 (en) | 2020-12-18 | 2022-06-23 | Genevant Sciences Gmbh | Peg lipids and lipid nanoparticles |
| EP4574172A3 (en) | 2022-01-31 | 2025-10-01 | Genevant Sciences Gmbh | Ionizable cationic lipids for lipid nanoparticles |
| WO2025052278A1 (en) | 2023-09-05 | 2025-03-13 | Genevant Sciences Gmbh | Pyrrolidine based cationic lipids for lipid nanoparticle delivery of therapeutics to hepatic stellate cells |
| WO2025133951A1 (en) | 2023-12-21 | 2025-06-26 | Genevant Sciences Gmbh | Ionizable lipids suitable for lipid nanoparticles |
Family Cites Families (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6174868B1 (en) * | 1992-09-10 | 2001-01-16 | Isis Pharmaceuticals, Inc. | Compositions and methods for treatment of hepatitis C virus-associated diseases |
| WO1995030746A1 (en) * | 1994-05-10 | 1995-11-16 | The General Hospital Corporation | Antisense inhibition of hepatitis c virus |
| US20030228597A1 (en) * | 1998-04-13 | 2003-12-11 | Cowsert Lex M. | Identification of genetic targets for modulation by oligonucleotides and generation of oligonucleotides for gene modulation |
| DE19956568A1 (de) | 1999-01-30 | 2000-08-17 | Roland Kreutzer | Verfahren und Medikament zur Hemmung der Expression eines vorgegebenen Gens |
| CZ302719B6 (cs) * | 2000-12-01 | 2011-09-21 | MAX-PLANCK-Gesellschaft zur Förderung der Wissenschaften e.V. | Izolovaná molekula dvouretezcové RNA, zpusob její výroby a její použití |
| EP1386004A4 (en) * | 2001-04-05 | 2005-02-16 | Ribozyme Pharm Inc | MODULATION OF GENE EXPRESSION ASSOCIATED WITH INFLAMMATORY PROLIFERATION AND GROWTH OF NEURITIES BY METHODS INVOLVING NUCLEIC ACID |
| US20040209831A1 (en) * | 2002-02-20 | 2004-10-21 | Mcswiggen James | RNA interference mediated inhibition of hepatitis C virus (HCV) gene expression using short interfering nucleic acid (siNA) |
| ES2386775T3 (es) * | 2001-07-23 | 2012-08-30 | The Board Of Trustees Of The Leland Stanford Junior University | Procedimientos y composiciones para la inhibición mediada por ARNi de la expresión génica en mamíferos |
| US10590418B2 (en) | 2001-07-23 | 2020-03-17 | The Board Of Trustees Of The Leland Stanford Junior University | Methods and compositions for RNAi mediated inhibition of gene expression in mammals |
| US7294504B1 (en) * | 2001-12-27 | 2007-11-13 | Allele Biotechnology & Pharmaceuticals, Inc. | Methods and compositions for DNA mediated gene silencing |
| EP1430157B1 (en) * | 2002-02-20 | 2011-08-10 | Sirna Therapeutics, Inc. | RNA INTERFERENCE MEDIATED INHIBITION OF HEPATITIS C VIRUS (HCV) GENE EXPRESSION USING SHORT INTERFERING NUCLEIC ACID (siNA) |
| WO2004027030A2 (en) * | 2002-09-18 | 2004-04-01 | Isis Pharmaceuticals, Inc. | Efficient reduction of target rna’s by single- and double-stranded oligomeric compounds |
| JP4228071B2 (ja) * | 2003-04-09 | 2009-02-25 | 独立行政法人産業技術総合研究所 | Ｃ型肝炎ウイルスのタンパク質合成及び／又はｃ型肝炎ウイルスの複製を抑制することができる二本鎖オリゴヌクレオチド |
| US7750144B2 (en) * | 2003-06-02 | 2010-07-06 | University Of Massachusetts | Methods and compositions for enhancing the efficacy and specificity of RNA silencing |
| US20090004739A1 (en) * | 2003-09-22 | 2009-01-01 | Taku Demura | Efficient Method of Preparing Dna Inverted Repeat |
| US20050164210A1 (en) * | 2004-01-23 | 2005-07-28 | Vivek Mittal | Regulated polymerase III expression systems and related methods |
| US20090170794A1 (en) | 2004-09-10 | 2009-07-02 | Somagenics Inc. | Small interfering rnas that efficiently inhibit viral expression and methods of use thereof |
| US20060142228A1 (en) | 2004-12-23 | 2006-06-29 | Ambion, Inc. | Methods and compositions concerning siRNA's as mediators of RNA interference |
| WO2010045384A2 (en) * | 2008-10-15 | 2010-04-22 | Somagenics Inc. | Short hairpin rnas for inhibition of gene expression |
-
2005
- 2005-09-12 US US11/662,506 patent/US20090170794A1/en not_active Abandoned
- 2005-09-12 EP EP05809901A patent/EP1793835A4/en not_active Withdrawn
- 2005-09-12 JP JP2007531467A patent/JP2008512500A/ja not_active Withdrawn
- 2005-09-12 WO PCT/US2005/032768 patent/WO2006031901A2/en not_active Ceased
-
2006
- 2006-06-01 US US11/444,901 patent/US7902351B2/en not_active Expired - Fee Related
-
2008
- 2008-03-11 IL IL190114A patent/IL190114A0/en unknown
-
2011
- 2011-03-02 US US13/039,100 patent/US8426380B2/en not_active Expired - Fee Related
-
2012
- 2012-01-27 US US13/360,442 patent/US20120220033A1/en not_active Abandoned
- 2012-03-01 JP JP2012045015A patent/JP2012136542A/ja active Pending
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