JP2008512500A - ウィルス遺伝子発現を効率的に阻害する低分子干渉ｒｎａおよびその使用方法 - Google Patents
ウィルス遺伝子発現を効率的に阻害する低分子干渉ｒｎａおよびその使用方法 Download PDFInfo
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
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| JP2008247818A (ja) * | 2007-03-30 | 2008-10-16 | Kyoto Univ | Ｃ型肝炎ウイルスの複製を制御するマイクロｒｎａ |
| WO2013065791A1 (ja) * | 2011-11-02 | 2013-05-10 | 公立大学法人大阪市立大学 | 遺伝子発現抑制用二本鎖核酸分子 |
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| WO2006031901A2 (en) | 2004-09-10 | 2006-03-23 | Somagenics, Inc. | SMALL INTERFERING RNAs THAT EFFICIENTLY INHIBIT VIRAL GENE EXPRESSION AND METHODS OF USE THEREOF |
| EP1849865B1 (en) * | 2005-01-28 | 2013-05-22 | Haplopharma Inc. | RNAi MEDICINE HAVING NO ADVERSE EFFECTS |
| CN101305095B (zh) * | 2005-09-12 | 2012-09-26 | 索马根尼科斯公司 | 利用小干扰rna抑制病毒基因表达 |
| EP2114416B1 (en) * | 2007-01-16 | 2015-08-05 | The University Of Queensland | Method of inducing an immune response |
| DK2308514T3 (da) | 2007-03-23 | 2013-09-02 | To Bbb Holding B V | Konjugater til målrettet lægemiddeltransport gennem blod-hjerne barrieren |
| CA2721333C (en) | 2008-04-15 | 2020-12-01 | Protiva Biotherapeutics, Inc. | Novel lipid formulations for nucleic acid delivery |
| US8680064B2 (en) * | 2008-09-15 | 2014-03-25 | The Board Of Trustees Of The Leland Stanford Junior University | ShRNA gene therapy for treatment of ischemic heart disease |
| CN102245772A (zh) | 2008-10-15 | 2011-11-16 | 索马根尼科斯公司 | 抑制基因表达的短发卡rna |
| CN102325534B (zh) * | 2008-12-18 | 2016-02-17 | 戴瑟纳制药公司 | 延长的dicer酶底物和特异性抑制基因表达的方法 |
| JP2012529892A (ja) * | 2009-06-19 | 2012-11-29 | コモンウェルス サイエンティフィック アンド インダストリアル リサーチ オーガニゼーション | ウイルス・アッセイ |
| JP5766188B2 (ja) | 2009-07-01 | 2015-08-19 | プロチバ バイオセラピューティクス インコーポレイティッド | 固形腫瘍に治療剤を送達するための脂質製剤 |
| EP2454371B1 (en) | 2009-07-13 | 2021-01-20 | Somagenics, Inc. | Chemical modification of small hairpin rnas for inhibition of gene expression |
| ES2699630T3 (es) | 2010-04-23 | 2019-02-12 | Cold Spring Harbor Laboratory | Novedosos ARNhc diseñados estructuralmente |
| WO2012053741A2 (ko) * | 2010-10-22 | 2012-04-26 | 성균관대학교산학협력단 | Rna 간섭을 유도하는 핵산 분자 및 그 용도 |
| US20120308642A1 (en) * | 2011-05-27 | 2012-12-06 | Xavier University Of Louisiana | Inhibiting hepatitis c viral replication with sirna combinations |
| NZ700075A (en) | 2012-02-24 | 2016-05-27 | Protiva Biotherapeutics Inc | Trialkyl cationic lipids and methods of use thereof |
| US10125362B2 (en) | 2012-05-22 | 2018-11-13 | Olix Pharmaceuticals, Inc. | RNA-interference-inducing nucleic acid molecule able to penetrate into cells, and use therefor |
| US10695548B1 (en) * | 2013-02-14 | 2020-06-30 | Transderm, Inc. | Gene silencing in skin using self-delivery siRNA delivered by a meso device |
| JP6426268B2 (ja) * | 2014-04-04 | 2018-11-21 | バイオニア コーポレーションＢｉｏｎｅｅｒ Ｃｏｒｐｏｒａｔｉｏｎ | 新規の二重らせんオリゴｒｎａおよびこれを含む線維症または呼吸器疾患の予防または治療用薬学組成物 |
| CN108699556B (zh) | 2015-11-16 | 2023-02-17 | 奥利克斯医药有限公司 | 使用靶向myd88或tlr3的rna复合物治疗老年性黄斑变性 |
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| KR101916652B1 (ko) | 2016-06-29 | 2018-11-08 | 올릭스 주식회사 | 작은 간섭 rna의 rna 간섭효과 증진용 화합물 및 이의 용도 |
| WO2018146557A2 (en) | 2017-02-10 | 2018-08-16 | Dong Ki Lee | Long double-stranded rna for rna interference |
| US20230150926A1 (en) | 2020-03-17 | 2023-05-18 | Genevant Sciences Gmbh | Cationic lipids for lipid nanoparticle delivery of therapeutics to hepatic stellate cells |
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| WO2026022677A1 (en) | 2024-07-22 | 2026-01-29 | Genevant Sciences Gmbh | Permanently charged cationic lipids |
| WO2026022656A2 (en) | 2024-07-22 | 2026-01-29 | Genevant Sciences Gmbh | Lipid particle formulations with permanently charged cationic lipids |
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| US20030228597A1 (en) * | 1998-04-13 | 2003-12-11 | Cowsert Lex M. | Identification of genetic targets for modulation by oligonucleotides and generation of oligonucleotides for gene modulation |
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| KR100909681B1 (ko) * | 2000-12-01 | 2009-07-29 | 막스-플랑크-게젤샤프트 츄어 푀르더룽 데어 비쎈샤프텐 에.파우. | Ｒｎａ 간섭을 매개하는 작은 ｒｎａ 분자 |
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| WO2006031901A2 (en) | 2004-09-10 | 2006-03-23 | Somagenics, Inc. | SMALL INTERFERING RNAs THAT EFFICIENTLY INHIBIT VIRAL GENE EXPRESSION AND METHODS OF USE THEREOF |
| US20060142228A1 (en) | 2004-12-23 | 2006-06-29 | Ambion, Inc. | Methods and compositions concerning siRNA's as mediators of RNA interference |
| CN102245772A (zh) * | 2008-10-15 | 2011-11-16 | 索马根尼科斯公司 | 抑制基因表达的短发卡rna |
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Patent Citations (1)
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| JP2004305140A (ja) * | 2003-04-09 | 2004-11-04 | National Institute Of Advanced Industrial & Technology | Ｃ型肝炎ウイルスのタンパク質合成及び／又はｃ型肝炎ウイルスの複製を抑制することができる二本鎖オリゴヌクレオチド |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2008247818A (ja) * | 2007-03-30 | 2008-10-16 | Kyoto Univ | Ｃ型肝炎ウイルスの複製を制御するマイクロｒｎａ |
| WO2013065791A1 (ja) * | 2011-11-02 | 2013-05-10 | 公立大学法人大阪市立大学 | 遺伝子発現抑制用二本鎖核酸分子 |
| JPWO2013065791A1 (ja) * | 2011-11-02 | 2015-04-02 | 公立大学法人大阪市立大学 | 遺伝子発現抑制用二本鎖核酸分子 |
| US9593331B2 (en) | 2011-11-02 | 2017-03-14 | Osaka City University | Double-stranded nucleic acid molecule for gene expression control |
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