JP2008512500A - ウィルス遺伝子発現を効率的に阻害する低分子干渉ｒｎａおよびその使用方法 - Google Patents
ウィルス遺伝子発現を効率的に阻害する低分子干渉ｒｎａおよびその使用方法 Download PDFInfo
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- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
- C12N15/1131—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against viruses
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| PCT/US2005/032768 WO2006031901A2 (en) | 2004-09-10 | 2005-09-12 | SMALL INTERFERING RNAs THAT EFFICIENTLY INHIBIT VIRAL GENE EXPRESSION AND METHODS OF USE THEREOF |
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| JP2012045015A Pending JP2012136542A (ja) | 2004-09-10 | 2012-03-01 | ウィルス遺伝子発現を効率的に阻害する低分子干渉ｒｎａおよびその使用方法 |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2008247818A (ja) * | 2007-03-30 | 2008-10-16 | Kyoto Univ | Ｃ型肝炎ウイルスの複製を制御するマイクロｒｎａ |
| WO2013065791A1 (ja) * | 2011-11-02 | 2013-05-10 | 公立大学法人大阪市立大学 | 遺伝子発現抑制用二本鎖核酸分子 |
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| US20090170794A1 (en) | 2004-09-10 | 2009-07-02 | Somagenics Inc. | Small interfering rnas that efficiently inhibit viral expression and methods of use thereof |
| JP4054844B2 (ja) * | 2005-01-28 | 2008-03-05 | 株式会社 ハプロファーマ | 副作用のないＲＮＡｉ医薬 |
| EP1979480A2 (en) * | 2005-09-12 | 2008-10-15 | Somagenics, Inc. | Inhibition of viral gene expression using small interfering rna |
| AU2007344641B2 (en) * | 2007-01-16 | 2014-05-22 | The University Of Queensland | Method of inducing an immune response |
| SI2308514T1 (sl) | 2007-03-23 | 2013-09-30 | To-Bbb Holding B.V. | Konjugati za prenos zdravila preko krvno-moĹľganske pregrade |
| NZ588583A (en) | 2008-04-15 | 2012-08-31 | Protiva Biotherapeutics Inc | Novel lipid formulations for nucleic acid delivery |
| WO2010030396A2 (en) * | 2008-09-15 | 2010-03-18 | Stanford University | Novel shrna gene therapy for treatment of ischemic heart disease |
| EP2352744B1 (en) | 2008-10-15 | 2016-09-21 | Somagenics, Inc. | Short hairpin rnas for inhibition of gene expression |
| EP2379083B1 (en) * | 2008-12-18 | 2017-08-16 | Dicerna Pharmaceuticals, Inc. | Extended dicer substrate agents and methods for the specific inhibition of gene expression |
| CN102803516A (zh) * | 2009-06-19 | 2012-11-28 | 联邦科学与工业研究机构 | 病毒试验 |
| US8283333B2 (en) | 2009-07-01 | 2012-10-09 | Protiva Biotherapeutics, Inc. | Lipid formulations for nucleic acid delivery |
| US8871730B2 (en) | 2009-07-13 | 2014-10-28 | Somagenics Inc. | Chemical modification of short small hairpin RNAs for inhibition of gene expression |
| DK2561078T3 (en) * | 2010-04-23 | 2019-01-14 | Cold Spring Harbor Laboratory | NEW STRUCTURALLY DESIGNED SHRNAs |
| EP2631291B1 (en) * | 2010-10-22 | 2019-05-15 | OliX Pharmaceuticals, Inc. | Nucleic acid molecules inducing rna interference, and uses thereof |
| US20120308642A1 (en) * | 2011-05-27 | 2012-12-06 | Xavier University Of Louisiana | Inhibiting hepatitis c viral replication with sirna combinations |
| DK2817287T3 (da) | 2012-02-24 | 2019-01-02 | Arbutus Biopharma Corp | Trialkyl kationisk lipid og metoder til anvendelse deraf |
| DK2853597T3 (en) | 2012-05-22 | 2019-04-08 | Olix Pharmaceuticals Inc | RNA INTERFERENCE-INducing NUCLEIC ACID MOLECULES WITH CELL PENETENING EQUIPMENT AND USE THEREOF |
| US10695548B1 (en) * | 2013-02-14 | 2020-06-30 | Transderm, Inc. | Gene silencing in skin using self-delivery siRNA delivered by a meso device |
| US10208309B2 (en) * | 2014-04-04 | 2019-02-19 | Bioneer Corporation | Double-stranded oligo RNA targeted to amphiregulin and pharmaceutical composition comprising same for preventing or treating fibrosis or respiratory diseases |
| EP3377630A4 (en) | 2015-11-16 | 2020-01-01 | Olix Pharmaceuticals, Inc. | Treatment of age-related macular degeneration using rna complexes that target myd88 or tlr3 |
| EP3411481A4 (en) | 2016-02-02 | 2020-02-26 | Olix Pharmaceuticals, Inc. | TREATMENT OF DISEASES ASSOCIATED WITH ANGIOGENESIS USING ANGPT2 AND PDGFB TARGETED RNA COMPLEXES |
| JP6944942B2 (ja) | 2016-02-02 | 2021-10-06 | オリックス ファーマシューティカルズ，インコーポレーテッド | ＩＬ４Ｒα、ＴＲＰＡ１、またはＦ２ＲＬ１を標的とするＲＮＡ複合体を用いたアトピー性皮膚炎および喘息の治療 |
| WO2017178883A2 (en) | 2016-04-11 | 2017-10-19 | Olix Pharmaceuticals, Inc. | Treatment of idiopathic pulmonary fibrosis using rna complexes that target connective tissue growth factor |
| KR101916652B1 (ko) | 2016-06-29 | 2018-11-08 | 올릭스 주식회사 | 작은 간섭 rna의 rna 간섭효과 증진용 화합물 및 이의 용도 |
| EP3580339A4 (en) | 2017-02-10 | 2020-12-23 | Research & Business Foundation Sungkyunkwan University | LONG DOUBLE STRAND RNA FOR RNA INTERFERENCE |
| EP4121018A4 (en) | 2020-03-17 | 2024-07-03 | Genevant Sciences Gmbh | CATIONIC LIPIDS FOR LIPID DNANOPARTICLE DELIVERY OF THERAPEUTICS TO HEPATIC STELLA CELLS |
| CN117479963A (zh) | 2020-12-18 | 2024-01-30 | 盖纳万科学有限公司 | Peg脂质和脂质纳米粒子 |
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| WO2025052278A1 (en) | 2023-09-05 | 2025-03-13 | Genevant Sciences Gmbh | Pyrrolidine based cationic lipids for lipid nanoparticle delivery of therapeutics to hepatic stellate cells |
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| WO2026022656A2 (en) | 2024-07-22 | 2026-01-29 | Genevant Sciences Gmbh | Lipid particle formulations with permanently charged cationic lipids |
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| JP2004305140A (ja) * | 2003-04-09 | 2004-11-04 | National Institute Of Advanced Industrial & Technology | Ｃ型肝炎ウイルスのタンパク質合成及び／又はｃ型肝炎ウイルスの複製を抑制することができる二本鎖オリゴヌクレオチド |
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| US6174868B1 (en) * | 1992-09-10 | 2001-01-16 | Isis Pharmaceuticals, Inc. | Compositions and methods for treatment of hepatitis C virus-associated diseases |
| JPH10503364A (ja) * | 1994-05-10 | 1998-03-31 | ザ ジェネラル ホスピタル コーポレーション | Ｃ型肝炎ウイルスのアンチセンス阻害 |
| US20030228597A1 (en) * | 1998-04-13 | 2003-12-11 | Cowsert Lex M. | Identification of genetic targets for modulation by oligonucleotides and generation of oligonucleotides for gene modulation |
| DE19956568A1 (de) | 1999-01-30 | 2000-08-17 | Roland Kreutzer | Verfahren und Medikament zur Hemmung der Expression eines vorgegebenen Gens |
| US20070026394A1 (en) * | 2000-02-11 | 2007-02-01 | Lawrence Blatt | Modulation of gene expression associated with inflammation proliferation and neurite outgrowth using nucleic acid based technologies |
| KR100872437B1 (ko) * | 2000-12-01 | 2008-12-05 | 막스-플랑크-게젤샤프트 츄어 푀르더룽 데어 비쎈샤프텐 에.파우. | Ｒｎａ 간섭을 매개하는 작은 ｒｎａ 분자 |
| US20040209831A1 (en) * | 2002-02-20 | 2004-10-21 | Mcswiggen James | RNA interference mediated inhibition of hepatitis C virus (HCV) gene expression using short interfering nucleic acid (siNA) |
| ES2386775T3 (es) * | 2001-07-23 | 2012-08-30 | The Board Of Trustees Of The Leland Stanford Junior University | Procedimientos y composiciones para la inhibición mediada por ARNi de la expresión génica en mamíferos |
| US10590418B2 (en) | 2001-07-23 | 2020-03-17 | The Board Of Trustees Of The Leland Stanford Junior University | Methods and compositions for RNAi mediated inhibition of gene expression in mammals |
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| GB2397062B (en) * | 2002-02-20 | 2005-06-15 | Sirna Therapeutics Inc | RNA interference mediated inhibition of hepatitis c virus (HCV) gene expression using short interfering nucleic acid (siNA) |
| WO2004027030A2 (en) * | 2002-09-18 | 2004-04-01 | Isis Pharmaceuticals, Inc. | Efficient reduction of target rna’s by single- and double-stranded oligomeric compounds |
| US7750144B2 (en) * | 2003-06-02 | 2010-07-06 | University Of Massachusetts | Methods and compositions for enhancing the efficacy and specificity of RNA silencing |
| EP1672064A4 (en) * | 2003-09-22 | 2006-12-20 | Riken | EFFICIENT METHOD FOR GENERATING AN INVERTED REPEAT DNA STRUCTURE |
| US20050164210A1 (en) * | 2004-01-23 | 2005-07-28 | Vivek Mittal | Regulated polymerase III expression systems and related methods |
| US20090170794A1 (en) | 2004-09-10 | 2009-07-02 | Somagenics Inc. | Small interfering rnas that efficiently inhibit viral expression and methods of use thereof |
| US20060142228A1 (en) | 2004-12-23 | 2006-06-29 | Ambion, Inc. | Methods and compositions concerning siRNA's as mediators of RNA interference |
| EP2352744B1 (en) * | 2008-10-15 | 2016-09-21 | Somagenics, Inc. | Short hairpin rnas for inhibition of gene expression |
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Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
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| JP2004305140A (ja) * | 2003-04-09 | 2004-11-04 | National Institute Of Advanced Industrial & Technology | Ｃ型肝炎ウイルスのタンパク質合成及び／又はｃ型肝炎ウイルスの複製を抑制することができる二本鎖オリゴヌクレオチド |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2008247818A (ja) * | 2007-03-30 | 2008-10-16 | Kyoto Univ | Ｃ型肝炎ウイルスの複製を制御するマイクロｒｎａ |
| WO2013065791A1 (ja) * | 2011-11-02 | 2013-05-10 | 公立大学法人大阪市立大学 | 遺伝子発現抑制用二本鎖核酸分子 |
| JPWO2013065791A1 (ja) * | 2011-11-02 | 2015-04-02 | 公立大学法人大阪市立大学 | 遺伝子発現抑制用二本鎖核酸分子 |
| US9593331B2 (en) | 2011-11-02 | 2017-03-14 | Osaka City University | Double-stranded nucleic acid molecule for gene expression control |
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| WO2006031901A2 (en) | 2006-03-23 |
| WO2006031901A3 (en) | 2006-09-08 |
| EP1793835A4 (en) | 2010-12-01 |
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| IL190114A0 (en) | 2008-08-07 |
| US20110269816A1 (en) | 2011-11-03 |
| US8426380B2 (en) | 2013-04-23 |
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| US20070149470A1 (en) | 2007-06-28 |
| US20120220033A1 (en) | 2012-08-30 |
| US7902351B2 (en) | 2011-03-08 |
| EP1793835A2 (en) | 2007-06-13 |
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