JP2008512500A - ウィルス遺伝子発現を効率的に阻害する低分子干渉ｒｎａおよびその使用方法 - Google Patents
ウィルス遺伝子発現を効率的に阻害する低分子干渉ｒｎａおよびその使用方法 Download PDFInfo
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- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
- C12N15/1131—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against viruses
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| PCT/US2005/032768 WO2006031901A2 (en) | 2004-09-10 | 2005-09-12 | SMALL INTERFERING RNAs THAT EFFICIENTLY INHIBIT VIRAL GENE EXPRESSION AND METHODS OF USE THEREOF |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2008247818A (ja) * | 2007-03-30 | 2008-10-16 | Kyoto Univ | Ｃ型肝炎ウイルスの複製を制御するマイクロｒｎａ |
| WO2013065791A1 (ja) * | 2011-11-02 | 2013-05-10 | 公立大学法人大阪市立大学 | 遺伝子発現抑制用二本鎖核酸分子 |
Families Citing this family (30)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2008512500A (ja) | 2004-09-10 | 2008-04-24 | ソマジェニックス インコーポレーティッド | ウィルス遺伝子発現を効率的に阻害する低分子干渉ｒｎａおよびその使用方法 |
| WO2006080564A1 (ja) * | 2005-01-28 | 2006-08-03 | Haplopharma Inc. | 副作用のないRNAi医薬 |
| CN102827841A (zh) * | 2005-09-12 | 2012-12-19 | 索马根尼科斯公司 | 利用小干扰rna抑制病毒基因表达 |
| EP3042959A1 (en) * | 2007-01-16 | 2016-07-13 | The University of Queensland | Method of inducing an immune response |
| US20100129437A1 (en) | 2007-03-23 | 2010-05-27 | Bbb Holding B.V. | Targeted intracellular delivery of antiviral agents |
| PL2279254T3 (pl) | 2008-04-15 | 2017-11-30 | Protiva Biotherapeutics Inc. | Nowe preparaty lipidowe do dostarczania kwasów nukleinowych |
| US8680064B2 (en) * | 2008-09-15 | 2014-03-25 | The Board Of Trustees Of The Leland Stanford Junior University | ShRNA gene therapy for treatment of ischemic heart disease |
| US8283460B2 (en) | 2008-10-15 | 2012-10-09 | Somagenics, Inc. | Short hairpin RNAs for inhibition of gene expression |
| AU2009336191B2 (en) * | 2008-12-18 | 2017-08-24 | Novo Nordisk A/S | Extended dicer substrate agents and methods for the specific inhibition of gene expression |
| WO2010144965A1 (en) * | 2009-06-19 | 2010-12-23 | Commonwealth Scientific And Industrial Research Organisation | Viral assay |
| JP5766188B2 (ja) | 2009-07-01 | 2015-08-19 | プロチバ バイオセラピューティクス インコーポレイティッド | 固形腫瘍に治療剤を送達するための脂質製剤 |
| WO2011008730A2 (en) | 2009-07-13 | 2011-01-20 | Somagenics Inc. | Chemical modification of small hairpin rnas for inhibition of gene expression |
| EP3502254B1 (en) | 2010-04-23 | 2024-11-06 | Cold Spring Harbor Laboratory | Novel structurally designed shrnas |
| EP3599280B1 (en) | 2010-10-22 | 2022-11-02 | OliX Pharmaceuticals, Inc. | Nucleic acid molecules inducing rna interference, and uses thereof |
| US20120308642A1 (en) * | 2011-05-27 | 2012-12-06 | Xavier University Of Louisiana | Inhibiting hepatitis c viral replication with sirna combinations |
| EP3473611B1 (en) | 2012-02-24 | 2021-10-20 | Arbutus Biopharma Corporation | Trialkyl cationic lipids and methods of use thereof |
| CN104755620B (zh) | 2012-05-22 | 2018-03-02 | 奥利克斯医药有限公司 | 具有细胞内穿透能力的诱导rna干扰的核酸分子及其用途 |
| US10695548B1 (en) * | 2013-02-14 | 2020-06-30 | Transderm, Inc. | Gene silencing in skin using self-delivery siRNA delivered by a meso device |
| ES2984979T3 (es) * | 2014-04-04 | 2024-10-31 | Bioneer Corp | Oligo ARN de doble cadena y composición farmacéutica que comprende el mismo para la prevención o tratamiento de fibrosis o enfermedades respiratorias |
| KR102727666B1 (ko) | 2015-11-16 | 2024-11-08 | 올릭스 주식회사 | MyD88 또는 TLR3을 타겟팅하는 RNA 복합체를 이용한 연령-관련 황반 변성의 치료 |
| KR102825946B1 (ko) | 2016-02-02 | 2025-06-27 | 올릭스 주식회사 | IL4Rα, TRPA1, 또는 F2RL1을 표적화하는 RNA 복합체를 사용한 아토피 피부염 및 천식의 치료 |
| US10519449B2 (en) | 2016-02-02 | 2019-12-31 | Olix Pharmaceuticals, Inc. | Treatment of angiogenesis-associated diseases using RNA complexes that target ANGPT2 and PDGFB |
| KR102339886B1 (ko) | 2016-04-11 | 2021-12-17 | 올릭스 주식회사 | 연결 조직 성장 인자를 표적화하는 rna 복합체를 사용한 특발성 폐 섬유증의 치료 방법 |
| KR101916652B1 (ko) | 2016-06-29 | 2018-11-08 | 올릭스 주식회사 | 작은 간섭 rna의 rna 간섭효과 증진용 화합물 및 이의 용도 |
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| WO2021188389A2 (en) | 2020-03-17 | 2021-09-23 | Genevant Sciences Gmbh | Cationic lipids for lipid nanoparticle delivery of therapeutics to hepatic stellate cells |
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| WO2025052278A1 (en) | 2023-09-05 | 2025-03-13 | Genevant Sciences Gmbh | Pyrrolidine based cationic lipids for lipid nanoparticle delivery of therapeutics to hepatic stellate cells |
| WO2025133951A1 (en) | 2023-12-21 | 2025-06-26 | Genevant Sciences Gmbh | Ionizable lipids suitable for lipid nanoparticles |
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| JP2004305140A (ja) * | 2003-04-09 | 2004-11-04 | National Institute Of Advanced Industrial & Technology | Ｃ型肝炎ウイルスのタンパク質合成及び／又はｃ型肝炎ウイルスの複製を抑制することができる二本鎖オリゴヌクレオチド |
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| US6174868B1 (en) * | 1992-09-10 | 2001-01-16 | Isis Pharmaceuticals, Inc. | Compositions and methods for treatment of hepatitis C virus-associated diseases |
| WO1995030746A1 (en) * | 1994-05-10 | 1995-11-16 | The General Hospital Corporation | Antisense inhibition of hepatitis c virus |
| US20030228597A1 (en) * | 1998-04-13 | 2003-12-11 | Cowsert Lex M. | Identification of genetic targets for modulation by oligonucleotides and generation of oligonucleotides for gene modulation |
| DE19956568A1 (de) | 1999-01-30 | 2000-08-17 | Roland Kreutzer | Verfahren und Medikament zur Hemmung der Expression eines vorgegebenen Gens |
| US20040259247A1 (en) * | 2000-12-01 | 2004-12-23 | Thomas Tuschl | Rna interference mediating small rna molecules |
| EP1386004A4 (en) * | 2001-04-05 | 2005-02-16 | Ribozyme Pharm Inc | MODULATION OF GENE EXPRESSION ASSOCIATED WITH INFLAMMATORY PROLIFERATION AND GROWTH OF NEURITIES BY METHODS INVOLVING NUCLEIC ACID |
| US20040209831A1 (en) * | 2002-02-20 | 2004-10-21 | Mcswiggen James | RNA interference mediated inhibition of hepatitis C virus (HCV) gene expression using short interfering nucleic acid (siNA) |
| US10590418B2 (en) | 2001-07-23 | 2020-03-17 | The Board Of Trustees Of The Leland Stanford Junior University | Methods and compositions for RNAi mediated inhibition of gene expression in mammals |
| DK1409506T3 (da) * | 2001-07-23 | 2012-08-06 | Univ Leland Stanford Junior | Fremgangsmåder og sammensætninger til RNAi-formidlet inhibering af genekspression i pattedyr |
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| AU2003273336A1 (en) * | 2002-09-18 | 2004-04-08 | Isis Pharmaceuticals, Inc. | Efficient reduction of target rna's by single- and double-stranded oligomeric compounds |
| US7750144B2 (en) * | 2003-06-02 | 2010-07-06 | University Of Massachusetts | Methods and compositions for enhancing the efficacy and specificity of RNA silencing |
| WO2005028646A1 (ja) * | 2003-09-22 | 2005-03-31 | Riken | 効率的なdna逆位反復構造の調製方法 |
| US20050164210A1 (en) * | 2004-01-23 | 2005-07-28 | Vivek Mittal | Regulated polymerase III expression systems and related methods |
| JP2008512500A (ja) | 2004-09-10 | 2008-04-24 | ソマジェニックス インコーポレーティッド | ウィルス遺伝子発現を効率的に阻害する低分子干渉ｒｎａおよびその使用方法 |
| US20060142228A1 (en) | 2004-12-23 | 2006-06-29 | Ambion, Inc. | Methods and compositions concerning siRNA's as mediators of RNA interference |
| US8283460B2 (en) * | 2008-10-15 | 2012-10-09 | Somagenics, Inc. | Short hairpin RNAs for inhibition of gene expression |
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Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2004305140A (ja) * | 2003-04-09 | 2004-11-04 | National Institute Of Advanced Industrial & Technology | Ｃ型肝炎ウイルスのタンパク質合成及び／又はｃ型肝炎ウイルスの複製を抑制することができる二本鎖オリゴヌクレオチド |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2008247818A (ja) * | 2007-03-30 | 2008-10-16 | Kyoto Univ | Ｃ型肝炎ウイルスの複製を制御するマイクロｒｎａ |
| WO2013065791A1 (ja) * | 2011-11-02 | 2013-05-10 | 公立大学法人大阪市立大学 | 遺伝子発現抑制用二本鎖核酸分子 |
| JPWO2013065791A1 (ja) * | 2011-11-02 | 2015-04-02 | 公立大学法人大阪市立大学 | 遺伝子発現抑制用二本鎖核酸分子 |
| US9593331B2 (en) | 2011-11-02 | 2017-03-14 | Osaka City University | Double-stranded nucleic acid molecule for gene expression control |
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| WO2006031901A3 (en) | 2006-09-08 |
| WO2006031901A2 (en) | 2006-03-23 |
| EP1793835A4 (en) | 2010-12-01 |
| US7902351B2 (en) | 2011-03-08 |
| US20070149470A1 (en) | 2007-06-28 |
| EP1793835A2 (en) | 2007-06-13 |
| US20120220033A1 (en) | 2012-08-30 |
| US20090170794A1 (en) | 2009-07-02 |
| US8426380B2 (en) | 2013-04-23 |
| US20110269816A1 (en) | 2011-11-03 |
| JP2012136542A (ja) | 2012-07-19 |
| IL190114A0 (en) | 2008-08-07 |
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