JP2024518546A5 - - Google Patents

Info

Publication number
JP2024518546A5
JP2024518546A5 JP2023570150A JP2023570150A JP2024518546A5 JP 2024518546 A5 JP2024518546 A5 JP 2024518546A5 JP 2023570150 A JP2023570150 A JP 2023570150A JP 2023570150 A JP2023570150 A JP 2023570150A JP 2024518546 A5 JP2024518546 A5 JP 2024518546A5
Authority
JP
Japan
Prior art keywords
nucleotides
modified
rna
sequence
modified rna
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2023570150A
Other languages
English (en)
Japanese (ja)
Other versions
JP2024518546A (ja
Filing date
Publication date
Application filed filed Critical
Priority claimed from PCT/US2022/028849 external-priority patent/WO2022241045A1/en
Publication of JP2024518546A publication Critical patent/JP2024518546A/ja
Publication of JP2024518546A5 publication Critical patent/JP2024518546A5/ja
Pending legal-status Critical Current

Links

JP2023570150A 2021-05-12 2022-05-11 修飾されたｍＲＮＡ、修飾された非コードＲＮＡ、およびその使用 Pending JP2024518546A (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US202163187752P 2021-05-12 2021-05-12
US63/187,752 2021-05-12
US202163288522P 2021-12-10 2021-12-10
US63/288,522 2021-12-10
PCT/US2022/028849 WO2022241045A1 (en) 2021-05-12 2022-05-11 Modified mrna, modified non-coding rna, and uses thereof

Publications (2)

Publication Number Publication Date
JP2024518546A JP2024518546A (ja) 2024-05-01
JP2024518546A5 true JP2024518546A5 (enExample) 2025-05-20

Family

ID=82163587

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2023570150A Pending JP2024518546A (ja) 2021-05-12 2022-05-11 修飾されたｍＲＮＡ、修飾された非コードＲＮＡ、およびその使用

Country Status (7)

Country Link
US (1) US20240277872A1 (enExample)
EP (1) EP4337331A1 (enExample)
JP (1) JP2024518546A (enExample)
KR (1) KR20240021170A (enExample)
AU (1) AU2022273530A1 (enExample)
CA (1) CA3218778A1 (enExample)
WO (1) WO2022241045A1 (enExample)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2023141474A1 (en) * 2022-01-18 2023-07-27 The Broad Institute, Inc. Poly-tailed and poly-capped mrna and uses thereof
CN114685586B (zh) * 2022-03-05 2025-07-18 武汉瑞佶生物科技有限公司 一种mRNA-脂肪酸靶向化合物及其制备方法和应用
JP2025519910A (ja) * 2022-06-24 2025-06-26 ザ・ブロード・インスティテュート・インコーポレイテッド キャップされた環状ｒｎａ分子を調製するための組成物及び方法
EP4655398A1 (en) * 2023-01-27 2025-12-03 Eleven Therapeutics Ltd Artificial polynucleotide molecules for enhanced stability and translation
KR20250166303A (ko) * 2023-03-29 2025-11-27 센젠 센신 바이오테크놀로지 컴퍼니 리미티드 폴리(a)를 포함하는 폴리뉴클레오타이드 분자 및 이의 용도
WO2025017029A1 (en) * 2023-07-17 2025-01-23 Eleven Therapeutics Ltd Non-natural building blocks for enhanced translation and stability of mrna
JP2025032058A (ja) * 2023-08-06 2025-03-11 シー‐ラン リン 新規なオキソ－ｒｎａ組成物及びその関連用途
WO2025111430A1 (en) * 2023-11-21 2025-05-30 Prime Medicine, Inc. CHEMICAL MODIFICATIONS IN mRNA POLY(A) TAIL
WO2025147660A2 (en) * 2024-01-04 2025-07-10 Trilink Biotechnologies, Llc Modified rna for increasing protein expression
WO2025175176A1 (en) * 2024-02-14 2025-08-21 Modernatx, Inc. Synthetic nucleic acids and methods of using the same for improved polypeptide production
WO2025217126A1 (en) * 2024-04-09 2025-10-16 Convergence Bio, Inc. Polynucleotides, 3' chain terminating tails, ligation and uses thereof
WO2025217135A1 (en) * 2024-04-09 2025-10-16 Convergence Bio, Inc. Rna ligation methods and products
WO2025227104A1 (en) * 2024-04-25 2025-10-30 Parcel Biosciences, Inc. Mrna complexes, their manufacturing, and their use for treatment
WO2026010855A1 (en) * 2024-07-02 2026-01-08 Trilink Biotechnologies, Llc Modified rna for increasing protein expression
WO2026011417A1 (en) * 2024-07-12 2026-01-15 The Hong Kong University Of Science And Technology Compositions and methods involving artificial poly (a) sequences

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2012019630A1 (en) * 2010-08-13 2012-02-16 Curevac Gmbh Nucleic acid comprising or coding for a histone stem-loop and a poly(a) sequence or a polyadenylation signal for increasing the expression of an encoded protein
CA3018046A1 (en) 2011-12-16 2013-06-20 Moderna Therapeutics, Inc. Modified nucleoside, nucleotide, and nucleic acid compositions
WO2013103659A1 (en) * 2012-01-04 2013-07-11 Board Of Supervisors Of Louisiana State University And Agricultural And Mechanical College Stabilizing rna by incorporating chain-terminating nucleosides at the 3'-terminus
JP6586075B2 (ja) 2013-03-14 2019-10-02 トランスレイト バイオ， インコーポレイテッド メッセンジャーｒｎａの精製方法
US9950065B2 (en) 2013-09-26 2018-04-24 Biontech Rna Pharmaceuticals Gmbh Particles comprising a shell with RNA
WO2015048744A2 (en) * 2013-09-30 2015-04-02 Moderna Therapeutics, Inc. Polynucleotides encoding immune modulating polypeptides
ES3032935T3 (en) 2013-10-22 2025-07-29 Translate Bio Inc Lipid formulations for delivery of messenger rna
AU2014348212C1 (en) 2013-11-18 2018-11-29 Arcturus Therapeutics, Inc. Ionizable cationic lipid for RNA delivery
US9365610B2 (en) 2013-11-18 2016-06-14 Arcturus Therapeutics, Inc. Asymmetric ionizable cationic lipid for RNA delivery
US9850269B2 (en) 2014-04-25 2017-12-26 Translate Bio, Inc. Methods for purification of messenger RNA
AU2015338923B2 (en) * 2014-11-02 2021-10-21 Arcturus Therapeutics, Inc. Messenger UNA molecules and uses thereof
WO2016155809A1 (en) 2015-03-31 2016-10-06 Biontech Rna Pharmaceuticals Gmbh Lipid particle formulations for delivery of rna and water-soluble therapeutically effective compounds to a target cell
US10808242B2 (en) 2015-08-28 2020-10-20 Biontech Rna Pharmaceuticals Gmbh Method for reducing immunogenicity of RNA
EP3585892B8 (en) 2017-02-27 2022-07-13 Translate Bio, Inc. Methods for purification of messenger rna
MA47824A (fr) 2017-03-07 2020-01-15 Translate Bio Inc Administration polyanionique d'acides nucléiques
MA53669A (fr) * 2018-09-20 2021-07-28 Modernatx Inc Compositions et procédés d'administration d'acides nucléiques
BR112021023411A2 (pt) 2019-05-22 2022-02-01 Massachusetts Inst Technology Composições e métodos de rna circular
JP2022552371A (ja) * 2019-10-15 2022-12-15 モデルナティエックス インコーポレイテッド 免疫調節ポリペプチドをコードするｍＲＮＡ及びその使用

Similar Documents

Publication Publication Date Title
JP2024518546A5 (enExample)
US20250084397A1 (en) Methods of purifying dna for gene synthesis
US20240425902A1 (en) Methods of purifying dna for gene synthesis
AU2014205648B2 (en) Templates, libraries, kits and methods for generating molecules
JP6219944B2 (ja) ５’保護に依存した増幅
WO2024010993A1 (en) Primer design for cell-free dna production
JP2023504264A5 (enExample)
CN115210372B (zh) 一种制备定点修饰的长链rna的方法
JP2026500787A (ja) Ｒｎａの環状化
JP2015536689A (ja) Ｐｅｇを介した核酸分子のアセンブリ
US12139731B2 (en) CRISPR-based programmable RNA editing
US20240368586A1 (en) Guide rna sequencing confirmation
EP3759243B1 (en) Methods and compositions for enriching nucleic acids
CN118742643A (zh) 利用哑铃结构制备环状rna的方法
US9944966B2 (en) Method for production of single-stranded macronucleotides
WO2022240991A1 (en) Gene assembly from oligonucleotide pools
CN114592022A (zh) 一种基于dna模板的长链tna合成方法
US20250043276A1 (en) Targeted Enrichment of Nucleic Acid Sequences
KR102818452B1 (ko) Rna 라이게이즈를 이용한 신규 원형 rna 합성법
EP4653530A1 (en) Artificial ribozymes and uses thereof
CN120310879A (zh) 制备mRNA转录模板的试剂盒和方法
WO2024260432A1 (zh) 线性rna的环化组件及其应用
CN121592760A (zh) 一种dI修饰引物促进核酸扩增反应的方法及其应用
US10087484B2 (en) Method for synthesizing gene using high-depth oligonucleotide tiling
CN116926149A (zh) dsRNA的制备方法及其在制备dsRNA标准品中的应用