JP2006526394A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2006526394A5 JP2006526394A5 JP2006508084A JP2006508084A JP2006526394A5 JP 2006526394 A5 JP2006526394 A5 JP 2006526394A5 JP 2006508084 A JP2006508084 A JP 2006508084A JP 2006508084 A JP2006508084 A JP 2006508084A JP 2006526394 A5 JP2006526394 A5 JP 2006526394A5
- Authority
- JP
- Japan
- Prior art keywords
- sequence
- effector
- rna
- substantially complementary
- nucleotides
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000012636 effector Substances 0.000 claims 41
- 229920002477 rna polymer Polymers 0.000 claims 18
- 230000000295 complement effect Effects 0.000 claims 16
- 239000002773 nucleotide Substances 0.000 claims 10
- 125000003729 nucleotide group Chemical group 0.000 claims 10
- 108091026890 Coding region Proteins 0.000 claims 9
- 108020004707 nucleic acids Proteins 0.000 claims 8
- 150000007523 nucleic acids Chemical class 0.000 claims 8
- 102000039446 nucleic acids Human genes 0.000 claims 8
- 108090000623 proteins and genes Proteins 0.000 claims 5
- 230000030279 gene silencing Effects 0.000 claims 2
- 238000012226 gene silencing method Methods 0.000 claims 2
- 230000002452 interceptive effect Effects 0.000 claims 2
- 108091028043 Nucleic acid sequence Proteins 0.000 claims 1
Applications Claiming Priority (8)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US47582703P | 2003-06-03 | 2003-06-03 | |
| US47961603P | 2003-06-17 | 2003-06-17 | |
| AU2003906281A AU2003906281A0 (en) | 2003-11-14 | Double-stranded nucleic acid | |
| US55050404P | 2004-03-05 | 2004-03-05 | |
| AU2004901258A AU2004901258A0 (en) | 2004-03-10 | Double-stranded nucleic acid | |
| US55392004P | 2004-03-17 | 2004-03-17 | |
| AU2004902279A AU2004902279A0 (en) | 2004-04-30 | Double-stranded nucleic acid | |
| PCT/AU2004/000759 WO2004106517A1 (en) | 2003-06-03 | 2004-06-03 | Double-stranded nucleic acid |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2006526394A JP2006526394A (ja) | 2006-11-24 |
| JP2006526394A5 true JP2006526394A5 (enExample) | 2008-12-04 |
Family
ID=33494383
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2006508084A Pending JP2006526394A (ja) | 2003-06-03 | 2004-06-03 | 二本鎖核酸 |
Country Status (7)
| Country | Link |
|---|---|
| US (2) | US20050059044A1 (enExample) |
| EP (1) | EP1633871A4 (enExample) |
| JP (1) | JP2006526394A (enExample) |
| AU (1) | AU2009202763A1 (enExample) |
| CA (1) | CA2527907A1 (enExample) |
| NZ (1) | NZ543815A (enExample) |
| WO (1) | WO2004106517A1 (enExample) |
Families Citing this family (27)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2005028646A1 (ja) * | 2003-09-22 | 2005-03-31 | Riken | 効率的なdna逆位反復構造の調製方法 |
| EP1718747B1 (en) * | 2004-02-06 | 2009-10-28 | Dharmacon, Inc. | Stabilized rnas as transfection controls and silencing reagents |
| US20090280567A1 (en) * | 2004-02-06 | 2009-11-12 | Dharmacon, Inc. | Stabilized sirnas as transfection controls and silencing reagents |
| KR101147147B1 (ko) * | 2004-04-01 | 2012-05-25 | 머크 샤프 앤드 돔 코포레이션 | Rna 간섭의 오프 타겟 효과 감소를 위한 변형된폴리뉴클레오타이드 |
| EP1807520B1 (en) * | 2004-10-25 | 2012-07-25 | Devgen NV | Rna constructs |
| ES2556272T3 (es) * | 2004-11-18 | 2016-01-14 | The Board Of Trustees Of The University Of Illinois | Constructos de ARNsi multicistrónico para inhibir tumores |
| US7923207B2 (en) | 2004-11-22 | 2011-04-12 | Dharmacon, Inc. | Apparatus and system having dry gene silencing pools |
| US7923206B2 (en) * | 2004-11-22 | 2011-04-12 | Dharmacon, Inc. | Method of determining a cellular response to a biological agent |
| US7935811B2 (en) * | 2004-11-22 | 2011-05-03 | Dharmacon, Inc. | Apparatus and system having dry gene silencing compositions |
| WO2006084209A2 (en) * | 2005-02-03 | 2006-08-10 | Benitec, Inc. | Rnai expression constructs |
| US20060223777A1 (en) * | 2005-03-29 | 2006-10-05 | Dharmacon, Inc. | Highly functional short hairpin RNA |
| JP5232990B2 (ja) * | 2005-11-08 | 2013-07-10 | 国立大学法人愛媛大学 | Akt遺伝子に特異的なsiRNA |
| DK2056845T3 (da) | 2006-08-08 | 2017-11-27 | Rheinische Friedrich-Wilhelms-Universität Bonn | Struktur og anvendelse af 5'-phosphat-oligonukleotider |
| AU2007299705B2 (en) * | 2006-09-22 | 2012-09-06 | Dharmacon, Inc. | Duplex oligonucleotide complexes and methods for gene silencing by RNA interference |
| US20100112687A1 (en) * | 2007-03-02 | 2010-05-06 | Mdrna, Inc. | Nucleic acid compounds for inhibiting erbb family gene expression and uses thereof |
| EP2121924A1 (en) * | 2007-03-02 | 2009-11-25 | MDRNA, Inc. | Nucleic acid compounds for inhibiting vegf family gene expression and uses thereof |
| EP2058401A1 (en) * | 2007-10-05 | 2009-05-13 | Genethon | Widespread gene delivery to motor neurons using peripheral injection of AAV vectors |
| US8188060B2 (en) | 2008-02-11 | 2012-05-29 | Dharmacon, Inc. | Duplex oligonucleotides with enhanced functionality in gene regulation |
| US9738680B2 (en) | 2008-05-21 | 2017-08-22 | Rheinische Friedrich-Wilhelms-Universität Bonn | 5′ triphosphate oligonucleotide with blunt end and uses thereof |
| KR20180110186A (ko) | 2010-10-28 | 2018-10-08 | 베니텍 바이오파마 리미티드 | Hbv 치료 |
| EP2508530A1 (en) | 2011-03-28 | 2012-10-10 | Rheinische Friedrich-Wilhelms-Universität Bonn | Purification of triphosphorylated oligonucleotides using capture tags |
| DK2798065T3 (da) * | 2011-12-27 | 2019-09-16 | Commw Scient Ind Res Org | Samtidig geninaktivering og undertrykkelse af geninaktivering i samme celle |
| WO2013160393A1 (en) * | 2012-04-26 | 2013-10-31 | Intana Bioscience Gmbh | HIGH COMPLEXITY siRNA POOLS |
| US10407677B2 (en) | 2012-04-26 | 2019-09-10 | Intana Bioscience Gmbh | High complexity siRNA pools |
| EP2712870A1 (en) | 2012-09-27 | 2014-04-02 | Rheinische Friedrich-Wilhelms-Universität Bonn | Novel RIG-I ligands and methods for producing them |
| WO2014117050A2 (en) * | 2013-01-26 | 2014-07-31 | Mirimus, Inc. | Modified mirna as a scaffold for shrna |
| GB2617512B (en) | 2019-04-05 | 2023-12-27 | Earli Inc | Improved methods and compositions for synthetic biomarkers |
Family Cites Families (32)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5208149A (en) * | 1983-10-20 | 1993-05-04 | The Research Foundation Of State University Of New York | Nucleic acid constructs containing stable stem and loop structures |
| US5190931A (en) * | 1983-10-20 | 1993-03-02 | The Research Foundation Of State University Of New York | Regulation of gene expression by employing translational inhibition of MRNA utilizing interfering complementary MRNA |
| US5272065A (en) * | 1983-10-20 | 1993-12-21 | Research Foundation Of State University Of New York | Regulation of gene expression by employing translational inhibition of MRNA utilizing interfering complementary MRNA |
| US5034323A (en) * | 1989-03-30 | 1991-07-23 | Dna Plant Technology Corporation | Genetic engineering of novel plant phenotypes |
| US5231020A (en) * | 1989-03-30 | 1993-07-27 | Dna Plant Technology Corporation | Genetic engineering of novel plant phenotypes |
| US6194140B1 (en) * | 1990-04-04 | 2001-02-27 | Chiron Corporation | HCV NS3 protein fragments having helicase activity and improved solubility |
| DK0527788T3 (da) * | 1990-04-04 | 2004-09-06 | Chiron Corp | Hepatitis C virus protease |
| US5714323A (en) * | 1991-08-30 | 1998-02-03 | The University Of Medecine And Dentistry Of New Jersey | Over expression of single-stranded molecules |
| EP0626998B1 (en) * | 1992-02-19 | 2001-10-31 | The State Of Oregon Acting By And Through The Oregon Stateboard Of Higher Education On Behalf Of The University Of Oregon | Production of viral resistant plants via introduction of untranslatable plus sense viral rna |
| DE4208107A1 (de) * | 1992-03-13 | 1993-09-16 | Bayer Ag | Pseudorabies-virus (prv)-polynukleotide und ihre verwendung zur herstellung von virusresistenten eukaryotischen zellen |
| US5624803A (en) * | 1993-10-14 | 1997-04-29 | The Regents Of The University Of California | In vivo oligonucleotide generator, and methods of testing the binding affinity of triplex forming oligonucleotides derived therefrom |
| US5686649A (en) * | 1994-03-22 | 1997-11-11 | The Rockefeller University | Suppression of plant gene expression using processing-defective RNA constructs |
| US6054299A (en) * | 1994-04-29 | 2000-04-25 | Conrad; Charles A. | Stem-loop cloning vector and method |
| US5814500A (en) * | 1996-10-31 | 1998-09-29 | The Johns Hopkins University School Of Medicine | Delivery construct for antisense nucleic acids and methods of use |
| US6506559B1 (en) * | 1997-12-23 | 2003-01-14 | Carnegie Institute Of Washington | Genetic inhibition by double-stranded RNA |
| US6218181B1 (en) * | 1998-03-18 | 2001-04-17 | The Salk Institute For Biological Studies | Retroviral packaging cell line |
| AUPP249298A0 (en) * | 1998-03-20 | 1998-04-23 | Ag-Gene Australia Limited | Synthetic genes and genetic constructs comprising same I |
| NZ506648A (en) * | 1998-03-20 | 2003-08-29 | Benitec Australia Ltd | Control of gene expression through introduction of synthetic tandem repeats to reduce translation of mRNA |
| EP2314700A1 (en) * | 1999-01-28 | 2011-04-27 | Medical College of Georgia Research Institute, Inc | Composition and method for in vivo and in vitro attenuation of gene expression using double stranded RNA |
| US6423885B1 (en) * | 1999-08-13 | 2002-07-23 | Commonwealth Scientific And Industrial Research Organization (Csiro) | Methods for obtaining modified phenotypes in plant cells |
| GB9927444D0 (en) * | 1999-11-19 | 2000-01-19 | Cancer Res Campaign Tech | Inhibiting gene expression |
| CA2403397A1 (en) * | 2000-03-16 | 2001-09-20 | Genetica, Inc. | Methods and compositions for rna interference |
| DK2796553T3 (da) * | 2000-03-30 | 2019-09-30 | Whitehead Inst Biomedical Res | Rna-sekvensspecifikke formidlere af rna-interferens |
| MXPA02012733A (es) * | 2000-06-23 | 2003-05-14 | Du Pont | Extrusturas recombinantes y su uso en la reduccion de la expresion de genes. |
| US7109393B2 (en) * | 2000-08-15 | 2006-09-19 | Mendel Biotechnology, Inc. | Methods of gene silencing using inverted repeat sequences |
| US20060008817A1 (en) * | 2000-12-08 | 2006-01-12 | Invitrogen Corporation | Methods and compositions for generating recombinant nucleic acid molecules |
| WO2003016572A1 (en) * | 2001-08-17 | 2003-02-27 | Eli Lilly And Company | Oligonucleotide therapeutics for treating hepatitis c virus infections |
| AU2002354121A1 (en) * | 2001-11-28 | 2003-06-10 | Toudai Tlo, Ltd. | siRNA Expression System and Method for Producing Functional Gene Knockdown Cell Using the Same |
| EP1490489B1 (en) * | 2002-03-14 | 2010-06-02 | Commonwealth Scientific and Industrial Research Organisation | Methods and means for monitoring and modulating gene silencing |
| DE10212892A1 (de) * | 2002-03-20 | 2003-10-09 | Basf Plant Science Gmbh | Konstrukte und Verfahren zur Regulation der Genexpression |
| EP1495141A4 (en) * | 2002-03-20 | 2006-03-22 | Massachusetts Inst Technology | THERAPY OF HIV |
| AU2003278202A1 (en) * | 2002-06-24 | 2004-01-06 | Baylor College Of Medicine | Inhibition of gene expression in vertebrates using double-stranded rna (rnai) |
-
2004
- 2004-06-03 WO PCT/AU2004/000759 patent/WO2004106517A1/en not_active Ceased
- 2004-06-03 EP EP04735856A patent/EP1633871A4/en not_active Withdrawn
- 2004-06-03 CA CA002527907A patent/CA2527907A1/en not_active Abandoned
- 2004-06-03 JP JP2006508084A patent/JP2006526394A/ja active Pending
- 2004-06-03 US US10/861,191 patent/US20050059044A1/en not_active Abandoned
- 2004-06-03 NZ NZ543815A patent/NZ543815A/en not_active IP Right Cessation
-
2009
- 2009-07-08 AU AU2009202763A patent/AU2009202763A1/en not_active Abandoned
-
2010
- 2010-10-28 US US12/914,893 patent/US20110117608A1/en not_active Abandoned
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2006526394A5 (enExample) | ||
| JP2010525813A5 (enExample) | ||
| JPWO2022067130A5 (enExample) | ||
| Carbonell et al. | Multi‐targeting of viral RNAs with synthetic trans‐acting small interfering RNAs enhances plant antiviral resistance | |
| Vembar et al. | Noncoding RNAs as emerging regulators of Plasmodium falciparum virulence gene expression | |
| JP2017509350A5 (enExample) | ||
| JP2012136542A5 (enExample) | ||
| JP2014527401A5 (enExample) | ||
| JP2005503802A5 (enExample) | ||
| JP2005501557A5 (enExample) | ||
| JP2008522585A5 (enExample) | ||
| JP2014525921A5 (enExample) | ||
| JP2007527244A5 (enExample) | ||
| JP2015518714A5 (enExample) | ||
| JP2012228256A5 (enExample) | ||
| JP2012502657A5 (enExample) | ||
| JP2010512747A5 (enExample) | ||
| JP2012223202A5 (enExample) | ||
| JP2010526542A5 (enExample) | ||
| JP2015128433A5 (enExample) | ||
| JP2003219893A5 (enExample) | ||
| JP2006521824A5 (enExample) | ||
| JP6069314B2 (ja) | 長鎖核酸分子の大規模合成方法 | |
| McKnight et al. | RNA as a target for developing antivirals | |
| EP3040423A3 (en) | Microrna and uses thereof |