JP2007503474A5 - - Google Patents
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- Publication number
- JP2007503474A5 JP2007503474A5 JP2006533810A JP2006533810A JP2007503474A5 JP 2007503474 A5 JP2007503474 A5 JP 2007503474A5 JP 2006533810 A JP2006533810 A JP 2006533810A JP 2006533810 A JP2006533810 A JP 2006533810A JP 2007503474 A5 JP2007503474 A5 JP 2007503474A5
- Authority
- JP
- Japan
- Prior art keywords
- seq
- sequence
- nucleotide sequence
- base pairs
- effector molecule
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000002773 nucleotide Substances 0.000 claims 30
- 125000003729 nucleotide group Chemical group 0.000 claims 30
- 239000012636 effector Substances 0.000 claims 20
- 239000000203 mixture Substances 0.000 claims 19
- 238000000034 method Methods 0.000 claims 16
- 210000004962 mammalian cell Anatomy 0.000 claims 15
- 102000040430 polynucleotide Human genes 0.000 claims 15
- 108091033319 polynucleotide Proteins 0.000 claims 15
- 239000002157 polynucleotide Substances 0.000 claims 15
- 108091032973 (ribonucleotides)n+m Proteins 0.000 claims 14
- 102000040650 (ribonucleotides)n+m Human genes 0.000 claims 13
- 230000002401 inhibitory effect Effects 0.000 claims 9
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 8
- 241000711549 Hepacivirus C Species 0.000 claims 7
- 241000124008 Mammalia Species 0.000 claims 6
- 210000004102 animal cell Anatomy 0.000 claims 6
- 239000013604 expression vector Substances 0.000 claims 6
- 241000700721 Hepatitis B virus Species 0.000 claims 5
- 102000014450 RNA Polymerase III Human genes 0.000 claims 4
- 108010078067 RNA Polymerase III Proteins 0.000 claims 4
- 210000005260 human cell Anatomy 0.000 claims 4
- 210000004027 cell Anatomy 0.000 claims 3
- 230000000295 complement effect Effects 0.000 claims 3
- 238000001727 in vivo Methods 0.000 claims 3
- 108091028043 Nucleic acid sequence Proteins 0.000 claims 2
- 108020004414 DNA Proteins 0.000 claims 1
- 208000006454 hepatitis Diseases 0.000 claims 1
- 231100000283 hepatitis Toxicity 0.000 claims 1
- 230000003612 virological effect Effects 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US47807603P | 2003-06-12 | 2003-06-12 | |
| US60/478,076 | 2003-06-12 | ||
| PCT/US2004/019229 WO2005014806A2 (en) | 2003-06-12 | 2004-06-10 | Conserved hbv and hcv sequences useful for gene silencing |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011148461A Division JP5593279B2 (ja) | 2003-06-12 | 2011-07-04 | 遺伝子サイレンシングに有用な保存されたｈｂｖ及びｈｃｖ配列 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2007503474A JP2007503474A (ja) | 2007-02-22 |
| JP2007503474A5 true JP2007503474A5 (enExample) | 2007-07-26 |
| JP4980716B2 JP4980716B2 (ja) | 2012-07-18 |
Family
ID=34135047
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2006533810A Expired - Fee Related JP4980716B2 (ja) | 2003-06-12 | 2004-06-10 | 遺伝子サイレンシングに有用な保存されたｈｂｖ及びｈｃｖ配列 |
| JP2011148461A Expired - Lifetime JP5593279B2 (ja) | 2003-06-12 | 2011-07-04 | 遺伝子サイレンシングに有用な保存されたｈｂｖ及びｈｃｖ配列 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011148461A Expired - Lifetime JP5593279B2 (ja) | 2003-06-12 | 2011-07-04 | 遺伝子サイレンシングに有用な保存されたｈｂｖ及びｈｃｖ配列 |
Country Status (13)
| Country | Link |
|---|---|
| US (1) | US8350021B2 (enExample) |
| EP (4) | EP3470518A1 (enExample) |
| JP (2) | JP4980716B2 (enExample) |
| CN (1) | CN1836042A (enExample) |
| AU (1) | AU2004263832B2 (enExample) |
| BR (1) | BRPI0411219A (enExample) |
| CA (2) | CA3040025C (enExample) |
| DK (1) | DK2270162T3 (enExample) |
| HU (1) | HUE042261T2 (enExample) |
| IL (1) | IL172268A0 (enExample) |
| SG (1) | SG173218A1 (enExample) |
| SI (1) | SI2270162T1 (enExample) |
| WO (1) | WO2005014806A2 (enExample) |
Families Citing this family (36)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8575327B2 (en) | 2003-06-12 | 2013-11-05 | Alnylam Pharmaceuticals, Inc. | Conserved HBV and HCV sequences useful for gene silencing |
| DK2270162T3 (en) * | 2003-06-12 | 2019-01-21 | Alnylam Pharmaceuticals Inc | PRESERVED HBV AND HCV SEQUENCES USED FOR GEN-SILENCING |
| US20070265220A1 (en) | 2004-03-15 | 2007-11-15 | City Of Hope | Methods and compositions for the specific inhibition of gene expression by double-stranded RNA |
| US8084599B2 (en) | 2004-03-15 | 2011-12-27 | City Of Hope | Methods and compositions for the specific inhibition of gene expression by double-stranded RNA |
| EP2270161A3 (en) | 2004-08-23 | 2011-02-02 | Alnylam Pharmaceuticals, Inc. | Multiple RNA polymerase III promoter expression constructs |
| EP1797185B1 (en) | 2004-09-24 | 2011-04-13 | Alnylam Pharmaceuticals, Inc. | Targeting opposite strand replication intermediates of single-stranded viruses by rnai |
| EP2316942B1 (en) * | 2004-12-22 | 2021-04-21 | Alnylam Pharmaceuticals, Inc. | Conserved hbv and hcv sequences useful for gene silencing |
| WO2011103394A2 (en) * | 2010-02-19 | 2011-08-25 | Agave Pharma Inc. | Methods for gene inhibition |
| AU2011223820B2 (en) | 2010-03-01 | 2016-01-14 | The Children's Hospital Of Philadelphia | Nucleic acids for targeting multiple regions of the HCV genome |
| JP2013537423A (ja) | 2010-08-17 | 2013-10-03 | メルク・シャープ・エンド・ドーム・コーポレイション | 低分子干渉核酸（ｓｉＮＡ）を用いたＢ型肝炎ウイルス（ＨＢＶ）遺伝子発現のＲＮＡ干渉媒介性阻害 |
| MX347253B (es) | 2011-04-21 | 2017-04-20 | Ionis Pharmaceuticals Inc | Modulación de la expresión del virus de hepatitis b (vhb). |
| NZ705730A (en) | 2012-08-30 | 2016-06-24 | Replicor Inc | Methods for the treatment of hepatitis b and hepatitis d infections |
| JP6566941B2 (ja) | 2013-06-28 | 2019-08-28 | ベイラー リサーチ インスティテュートＢａｙｌｏｒ Ｒｅｓｅａｒｃｈ Ｉｎｓｔｉｔｕｔｅ | 多発性硬化症のための樹状細胞ａｓｇｐｒ標的化免疫治療薬 |
| CN105899658B (zh) | 2013-12-12 | 2020-02-18 | 布罗德研究所有限公司 | 针对hbv和病毒性疾病以及障碍的crispr-cas系统和组合物的递送、用途和治疗应用 |
| JOP20200092A1 (ar) | 2014-11-10 | 2017-06-16 | Alnylam Pharmaceuticals Inc | تركيبات iRNA لفيروس الكبد B (HBV) وطرق لاستخدامها |
| AU2016257150B2 (en) * | 2015-05-06 | 2022-03-31 | Benitec IP Holdings Inc. | Reagents for treatment of hepatitis B virus (HBV) infection and use thereof |
| US20170137821A1 (en) | 2015-07-17 | 2017-05-18 | Arcturus Therapeutics, Inc. | Molecules and agents for treating hepatitis b virus |
| WO2017015175A1 (en) | 2015-07-17 | 2017-01-26 | Arcturus Therapeutics, Inc. | Compositions and agents against hepatitis b virus and uses thereof |
| TWI840950B (zh) | 2016-03-14 | 2024-05-01 | 瑞士商赫孚孟拉羅股份公司 | 用於降低pd-l1表現之寡核苷酸 |
| EP3472346B1 (en) | 2016-06-17 | 2023-01-18 | F. Hoffmann-La Roche AG | Papd5 and papd7 inhibitors for treating a hepatitis b infection |
| WO2018102397A1 (en) | 2016-11-29 | 2018-06-07 | PureTech Health LLC | Exosomes for delivery of therapeutic agents |
| US11324820B2 (en) | 2017-04-18 | 2022-05-10 | Alnylam Pharmaceuticals, Inc. | Methods for the treatment of subjects having a hepatitis b virus (HBV) infection |
| WO2019051812A1 (zh) * | 2017-09-15 | 2019-03-21 | 深圳华大智造科技有限公司 | 确定预定染色体保守区域的方法、确定样本基因组中是否存在拷贝数变异的方法、系统和计算机可读介质 |
| TW202424191A (zh) | 2017-10-16 | 2024-06-16 | 瑞士商赫孚孟拉羅股份公司 | 用於降低PAPD5及PAPD7 mRNA以治療B型肝炎感染之核酸分子 |
| SG11202009680XA (en) | 2018-04-05 | 2020-10-29 | Hoffmann La Roche | Use of fubp1 inhibitors for treating hepatitis b virus infection |
| PE20220013A1 (es) | 2018-07-03 | 2022-01-11 | Hoffmann La Roche | Oligonucleotidos para modular la expresion de tau |
| BR112021000538A2 (pt) | 2018-07-13 | 2021-04-06 | F. Hoffmann-La Roche Ag | Oligonucleotídeos para modular a expressão de rtel1 |
| MX2021001056A (es) | 2018-08-13 | 2021-04-12 | Alnylam Pharmaceuticals Inc | Composiciones de agente de acido ribonucleico bicatenario (arnbc) de virus de la hepatitis b (vhb) y metodos de uso de las mismas. |
| CN114829601A (zh) | 2019-12-19 | 2022-07-29 | 豪夫迈·罗氏有限公司 | Sbds抑制剂用于治疗乙型肝炎病毒感染的用途 |
| CN114867856A (zh) | 2019-12-19 | 2022-08-05 | 豪夫迈·罗氏有限公司 | Saraf抑制剂用于治疗乙型肝炎病毒感染的用途 |
| JP7634542B2 (ja) | 2019-12-19 | 2025-02-21 | エフ． ホフマン－ラ ロシュ アーゲー | Ｂ型肝炎ウイルス感染症を処置するためのｓｅｐｔ９阻害剤の使用 |
| JP2023506540A (ja) | 2019-12-19 | 2023-02-16 | エフ． ホフマン－ラ ロシュ エージー． | Ｂ型肝炎ウイルス感染を処置するためのｓｃａｍｐ３阻害剤の使用 |
| JP7653997B2 (ja) | 2019-12-19 | 2025-03-31 | エフ． ホフマン－ラ ロシュ アーゲー | Ｂ型肝炎ウイルス感染を処置するためのｃｏｐｓ３阻害剤の使用 |
| JP2023538630A (ja) | 2020-08-21 | 2023-09-08 | エフ． ホフマン－ラ ロシュ アーゲー | Ｂ型肝炎ウイルス感染症を処置するためのａ１ｃｆ阻害剤の使用 |
| TW202246500A (zh) | 2021-02-02 | 2022-12-01 | 瑞士商赫孚孟拉羅股份公司 | 用於抑制 ｒｔｅｌ１ 表現之增強型寡核苷酸 |
| WO2023111210A1 (en) | 2021-12-17 | 2023-06-22 | F. Hoffmann-La Roche Ag | Combination of oligonucleotides for modulating rtel1 and fubp1 |
Family Cites Families (47)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5643771A (en) | 1980-05-19 | 1997-07-01 | The Board Of Trustees Of The Leland Stanford Junior University | Non-reverting live bacterial vaccines |
| US4897355A (en) | 1985-01-07 | 1990-01-30 | Syntex (U.S.A.) Inc. | N[ω,(ω-1)-dialkyloxy]- and N-[ω,(ω-1)-dialkenyloxy]-alk-1-yl-N,N,N-tetrasubstituted ammonium lipids and uses therefor |
| DE68927996T2 (de) | 1988-02-05 | 1997-12-04 | Hughes Howard Med Inst | Modifizierte hepatozyten und deren anwendung |
| US5703055A (en) | 1989-03-21 | 1997-12-30 | Wisconsin Alumni Research Foundation | Generation of antibodies through lipid mediated DNA delivery |
| US5279833A (en) | 1990-04-04 | 1994-01-18 | Yale University | Liposomal transfection of nucleic acids into animal cells |
| US5264618A (en) | 1990-04-19 | 1993-11-23 | Vical, Inc. | Cationic lipids for intracellular delivery of biologically active molecules |
| WO1991019809A1 (en) | 1990-06-18 | 1991-12-26 | The United States Of America, As Represented By The Secretary, U.S. Department Of Commerce | Eukaryotic expression vector system |
| US5283185A (en) | 1991-08-28 | 1994-02-01 | University Of Tennessee Research Corporation | Method for delivering nucleic acids into cells |
| US20030206887A1 (en) * | 1992-05-14 | 2003-11-06 | David Morrissey | RNA interference mediated inhibition of hepatitis B virus (HBV) using short interfering nucleic acid (siNA) |
| US5593972A (en) | 1993-01-26 | 1997-01-14 | The Wistar Institute | Genetic immunization |
| US5739118A (en) | 1994-04-01 | 1998-04-14 | Apollon, Inc. | Compositions and methods for delivery of genetic material |
| JPH10503364A (ja) * | 1994-05-10 | 1998-03-31 | ザ ジェネラル ホスピタル コーポレーション | Ｃ型肝炎ウイルスのアンチセンス阻害 |
| JPH07303485A (ja) * | 1994-05-13 | 1995-11-21 | Tonen Corp | Ｈｃｖアンチセンスｒｎａ、それを含む発現ベクター、及び該ｒｎａ又は発現ベクターを含むｈｃｖ関連疾患治療剤 |
| US5646262A (en) * | 1994-07-28 | 1997-07-08 | Georgetown University | Antisense oligonucleotides against hepatitis B viral replication |
| US5837533A (en) | 1994-09-28 | 1998-11-17 | American Home Products Corporation | Complexes comprising a nucleic acid bound to a cationic polyamine having an endosome disruption agent |
| US5571026A (en) * | 1994-12-09 | 1996-11-05 | Kcs Industries, Inc. | Flat mount electrode socket |
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| US5877159A (en) | 1995-05-03 | 1999-03-02 | University Of Maryland At Baltimore | Method for introducing and expressing genes in animal cells and live invasive bacterial vectors for use in the same |
| US5932241A (en) | 1995-06-07 | 1999-08-03 | Valentis, Incorporated | Cationic lipid DNA complexes for gene targeting |
| US5824538A (en) | 1995-09-06 | 1998-10-20 | The United States Of America As Represented By The Secretary Of The Army | Shigella vector for delivering DNA to a mammalian cell |
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| US6610478B1 (en) * | 1996-08-16 | 2003-08-26 | Yale University | Phenotypic conversion of cells mediated by external guide sequences |
| US5981274A (en) * | 1996-09-18 | 1999-11-09 | Tyrrell; D. Lorne J. | Recombinant hepatitis virus vectors |
| US6217900B1 (en) | 1997-04-30 | 2001-04-17 | American Home Products Corporation | Vesicular complexes and methods of making and using the same |
| DE19725803C1 (de) | 1997-06-18 | 1999-02-11 | Deutsches Krebsforsch | HBV-gerichtete Antisense-Nukleinsäuren |
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| US6506559B1 (en) | 1997-12-23 | 2003-01-14 | Carnegie Institute Of Washington | Genetic inhibition by double-stranded RNA |
| DE69902086T2 (de) * | 1998-01-27 | 2003-03-13 | Cytocell Ltd., Banbury | Verfahren zum nachweis von nukleinsäure-zielsequenzen mittels in vitro transkription von einem rna-promoter |
| KR20010041902A (ko) | 1998-03-16 | 2001-05-25 | 데이비드 엠 모이어 | 포유류의 피부 내의 셀룰라이트를 감소시키는 방법 |
| BR0009884A (pt) | 1999-04-21 | 2002-01-08 | American Home Prod | Processos e composições para a inibição da função das sequências de polinucleotìdeos |
| US6533250B2 (en) | 1999-10-15 | 2003-03-18 | W. Eugene Arthur | Energy dissipating system for a concrete roadway barrier |
| WO2003070918A2 (en) | 2002-02-20 | 2003-08-28 | Ribozyme Pharmaceuticals, Incorporated | Rna interference by modified short interfering nucleic acid |
| PT1309726E (pt) * | 2000-03-30 | 2010-03-08 | Whitehead Biomedical Inst | Mediadores de interferência por rna específicos de sequência de rna |
| US7439016B1 (en) * | 2000-06-15 | 2008-10-21 | Digene Corporation | Detection of nucleic acids by type-specific hybrid capture method |
| US6680059B2 (en) * | 2000-08-29 | 2004-01-20 | Tripep Ab | Vaccines containing ribavirin and methods of use thereof |
| US6443403B1 (en) | 2000-09-11 | 2002-09-03 | Panduit Corp. | Cable routing clamp and method of application |
| JP2002335968A (ja) | 2001-05-16 | 2002-11-26 | Kokuritsu Iyakuhin Shokuhin Eisei Kenkyusho | 新規転写因子、その遺伝子及びその結合ｄｎａ配列 |
| IL159756A0 (en) | 2001-07-12 | 2004-06-20 | Univ Massachusetts | IN VIVO PRODUCTION OF SMALL INTERFERING RNAs THAT MEDIATE GENE SILENCING |
| AU2002321859A1 (en) | 2001-08-03 | 2003-02-24 | Michael Van Der Sleesen | Protective garment |
| US7103761B2 (en) | 2001-08-07 | 2006-09-05 | Hewlett-Packard Development Company, Lp. | Server system with multiple management user interfaces |
| US6673661B1 (en) | 2002-12-20 | 2004-01-06 | Taiwan Semiconductor Manufacturing Co., Ltd. | Self-aligned method for forming dual gate thin film transistor (TFT) device |
| JP4545091B2 (ja) | 2003-01-24 | 2010-09-15 | 財団法人 東京都医学研究機構 | Ｃ型肝炎ウイルスの働きを阻害するオリゴリボヌクレオチドまたはペプチド核酸 |
| CN1257284C (zh) | 2003-03-05 | 2006-05-24 | 北京博奥生物芯片有限责任公司 | 一种体外阻断乙肝病毒表达的方法 |
| DK2270162T3 (en) | 2003-06-12 | 2019-01-21 | Alnylam Pharmaceuticals Inc | PRESERVED HBV AND HCV SEQUENCES USED FOR GEN-SILENCING |
| EP2270161A3 (en) * | 2004-08-23 | 2011-02-02 | Alnylam Pharmaceuticals, Inc. | Multiple RNA polymerase III promoter expression constructs |
| JP2015086965A (ja) | 2013-10-31 | 2015-05-07 | 株式会社エクセディ | フライホイール組立体 |
-
2004
- 2004-06-10 DK DK10180048.0T patent/DK2270162T3/en active
- 2004-06-10 SI SI200432456T patent/SI2270162T1/sl unknown
- 2004-06-10 EP EP18192425.9A patent/EP3470518A1/en active Pending
- 2004-06-10 JP JP2006533810A patent/JP4980716B2/ja not_active Expired - Fee Related
- 2004-06-10 BR BRPI0411219-9A patent/BRPI0411219A/pt not_active Application Discontinuation
- 2004-06-10 CA CA3040025A patent/CA3040025C/en not_active Expired - Lifetime
- 2004-06-10 EP EP10180047A patent/EP2284268A3/en not_active Withdrawn
- 2004-06-10 EP EP04776661A patent/EP1631670B1/en not_active Expired - Lifetime
- 2004-06-10 US US10/560,377 patent/US8350021B2/en not_active Expired - Fee Related
- 2004-06-10 CN CNA2004800228949A patent/CN1836042A/zh active Pending
- 2004-06-10 AU AU2004263832A patent/AU2004263832B2/en not_active Expired
- 2004-06-10 HU HUE10180048A patent/HUE042261T2/hu unknown
- 2004-06-10 CA CA2528510A patent/CA2528510C/en not_active Expired - Lifetime
- 2004-06-10 EP EP10180048.0A patent/EP2270162B1/en not_active Expired - Lifetime
- 2004-06-10 WO PCT/US2004/019229 patent/WO2005014806A2/en not_active Ceased
- 2004-06-10 SG SG2007044373A patent/SG173218A1/en unknown
-
2005
- 2005-11-30 IL IL172268A patent/IL172268A0/en unknown
-
2011
- 2011-07-04 JP JP2011148461A patent/JP5593279B2/ja not_active Expired - Lifetime
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