JP2007503474A5 - - Google Patents
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- Publication number
- JP2007503474A5 JP2007503474A5 JP2006533810A JP2006533810A JP2007503474A5 JP 2007503474 A5 JP2007503474 A5 JP 2007503474A5 JP 2006533810 A JP2006533810 A JP 2006533810A JP 2006533810 A JP2006533810 A JP 2006533810A JP 2007503474 A5 JP2007503474 A5 JP 2007503474A5
- Authority
- JP
- Japan
- Prior art keywords
- seq
- sequence
- nucleotide sequence
- base pairs
- effector molecule
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000002773 nucleotide Substances 0.000 claims 30
- 125000003729 nucleotide group Chemical group 0.000 claims 30
- 239000012636 effector Substances 0.000 claims 20
- 239000000203 mixture Substances 0.000 claims 19
- 238000000034 method Methods 0.000 claims 16
- 210000004962 mammalian cell Anatomy 0.000 claims 15
- 102000040430 polynucleotide Human genes 0.000 claims 15
- 108091033319 polynucleotide Proteins 0.000 claims 15
- 239000002157 polynucleotide Substances 0.000 claims 15
- 108091032973 (ribonucleotides)n+m Proteins 0.000 claims 14
- 102000040650 (ribonucleotides)n+m Human genes 0.000 claims 13
- 230000002401 inhibitory effect Effects 0.000 claims 9
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 8
- 241000711549 Hepacivirus C Species 0.000 claims 7
- 241000124008 Mammalia Species 0.000 claims 6
- 210000004102 animal cell Anatomy 0.000 claims 6
- 239000013604 expression vector Substances 0.000 claims 6
- 241000700721 Hepatitis B virus Species 0.000 claims 5
- 102000014450 RNA Polymerase III Human genes 0.000 claims 4
- 108010078067 RNA Polymerase III Proteins 0.000 claims 4
- 210000005260 human cell Anatomy 0.000 claims 4
- 210000004027 cell Anatomy 0.000 claims 3
- 230000000295 complement effect Effects 0.000 claims 3
- 238000001727 in vivo Methods 0.000 claims 3
- 108091028043 Nucleic acid sequence Proteins 0.000 claims 2
- 108020004414 DNA Proteins 0.000 claims 1
- 208000006454 hepatitis Diseases 0.000 claims 1
- 231100000283 hepatitis Toxicity 0.000 claims 1
- 230000003612 virological effect Effects 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US47807603P | 2003-06-12 | 2003-06-12 | |
| US60/478,076 | 2003-06-12 | ||
| PCT/US2004/019229 WO2005014806A2 (en) | 2003-06-12 | 2004-06-10 | Conserved hbv and hcv sequences useful for gene silencing |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011148461A Division JP5593279B2 (ja) | 2003-06-12 | 2011-07-04 | 遺伝子サイレンシングに有用な保存されたｈｂｖ及びｈｃｖ配列 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2007503474A JP2007503474A (ja) | 2007-02-22 |
| JP2007503474A5 true JP2007503474A5 (enExample) | 2007-07-26 |
| JP4980716B2 JP4980716B2 (ja) | 2012-07-18 |
Family
ID=34135047
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2006533810A Expired - Fee Related JP4980716B2 (ja) | 2003-06-12 | 2004-06-10 | 遺伝子サイレンシングに有用な保存されたｈｂｖ及びｈｃｖ配列 |
| JP2011148461A Expired - Lifetime JP5593279B2 (ja) | 2003-06-12 | 2011-07-04 | 遺伝子サイレンシングに有用な保存されたｈｂｖ及びｈｃｖ配列 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011148461A Expired - Lifetime JP5593279B2 (ja) | 2003-06-12 | 2011-07-04 | 遺伝子サイレンシングに有用な保存されたｈｂｖ及びｈｃｖ配列 |
Country Status (13)
| Country | Link |
|---|---|
| US (1) | US8350021B2 (enExample) |
| EP (4) | EP2270162B1 (enExample) |
| JP (2) | JP4980716B2 (enExample) |
| CN (1) | CN1836042A (enExample) |
| AU (1) | AU2004263832B2 (enExample) |
| BR (1) | BRPI0411219A (enExample) |
| CA (2) | CA3040025C (enExample) |
| DK (1) | DK2270162T3 (enExample) |
| HU (1) | HUE042261T2 (enExample) |
| IL (1) | IL172268A0 (enExample) |
| SG (1) | SG173218A1 (enExample) |
| SI (1) | SI2270162T1 (enExample) |
| WO (1) | WO2005014806A2 (enExample) |
Families Citing this family (36)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8575327B2 (en) | 2003-06-12 | 2013-11-05 | Alnylam Pharmaceuticals, Inc. | Conserved HBV and HCV sequences useful for gene silencing |
| JP4980716B2 (ja) * | 2003-06-12 | 2012-07-18 | アルナイラム ファーマシューティカルズ， インコーポレイテッド | 遺伝子サイレンシングに有用な保存されたｈｂｖ及びｈｃｖ配列 |
| WO2005089287A2 (en) | 2004-03-15 | 2005-09-29 | City Of Hope | Methods and compositions for the specific inhibition of gene expression by double-stranded rna |
| US20070265220A1 (en) | 2004-03-15 | 2007-11-15 | City Of Hope | Methods and compositions for the specific inhibition of gene expression by double-stranded RNA |
| EP1784492B1 (en) | 2004-08-23 | 2010-10-06 | Alnylam Pharmaceuticals, Inc. | Multiple rna polymerase iii promoter expression constructs |
| DE602005027479D1 (de) | 2004-09-24 | 2011-05-26 | Alnylam Pharmaceuticals Inc | Targeting von zwischenprodukten zur gegenstrangreplikation von einzelstrangigen viren durch rnai |
| EP1833967B1 (en) * | 2004-12-22 | 2011-04-27 | Alnylam Pharmaceuticals, Inc. | Conserved hbv and hcv sequences useful for gene silencing |
| WO2011103394A2 (en) * | 2010-02-19 | 2011-08-25 | Agave Pharma Inc. | Methods for gene inhibition |
| AU2011223820B2 (en) | 2010-03-01 | 2016-01-14 | The Children's Hospital Of Philadelphia | Nucleic acids for targeting multiple regions of the HCV genome |
| EP3587574B1 (en) * | 2010-08-17 | 2022-03-16 | Sirna Therapeutics, Inc. | Rna interference mediated inhibition of hepatitis b virus (hbv) gene expression using short interfering nucleic acid (sina) |
| CR20190207A (es) | 2011-04-21 | 2019-06-26 | Ionis Pharmaceuticals Inc | MODULACIÓN DE LA EXPRESIÓN DEL VIRUS DE LA HEPATITIS B (VHB) (Divisional 2013-0551) |
| KR20150046309A (ko) | 2012-08-30 | 2015-04-29 | 레플리코르 인코포레이티드 | Ｂ형 간염 및 ｄ형 간염 감염증의 치료 방법 |
| CA2916694C (en) | 2013-06-28 | 2023-01-17 | Baylor Research Institute | Dendritic cell asgpr targeting immunotherapeutics for multiple sclerosis |
| WO2015089465A1 (en) | 2013-12-12 | 2015-06-18 | The Broad Institute Inc. | Delivery, use and therapeutic applications of the crispr-cas systems and compositions for hbv and viral diseases and disorders |
| JOP20200092A1 (ar) | 2014-11-10 | 2017-06-16 | Alnylam Pharmaceuticals Inc | تركيبات iRNA لفيروس الكبد B (HBV) وطرق لاستخدامها |
| EP3292202A4 (en) * | 2015-05-06 | 2019-04-10 | Benitec Biopharma Limited | REAGENTS FOR THE TREATMENT OF HEPATITIS B VIRUS INFECTION AND USE THEREOF |
| AU2016296592B2 (en) | 2015-07-17 | 2021-08-19 | Arcturus Therapeutics, Inc. | Compositions and agents against Hepatitis B virus and uses thereof |
| US20170137821A1 (en) | 2015-07-17 | 2017-05-18 | Arcturus Therapeutics, Inc. | Molecules and agents for treating hepatitis b virus |
| CA3120687A1 (en) | 2016-03-14 | 2017-09-21 | F. Hoffmann-La Roche Ag | Oligonucleotides for reduction of pd-l1 expression |
| MA45496A (fr) | 2016-06-17 | 2019-04-24 | Hoffmann La Roche | Molécules d'acide nucléique pour la réduction de l'arnm de padd5 ou pad7 pour le traitement d'une infection par l'hépatite b |
| EP3548005A4 (en) | 2016-11-29 | 2020-06-17 | Puretech Health LLC | Exosomes for delivery of therapeutic agents |
| US11324820B2 (en) | 2017-04-18 | 2022-05-10 | Alnylam Pharmaceuticals, Inc. | Methods for the treatment of subjects having a hepatitis b virus (HBV) infection |
| WO2019051812A1 (zh) * | 2017-09-15 | 2019-03-21 | 深圳华大智造科技有限公司 | 确定预定染色体保守区域的方法、确定样本基因组中是否存在拷贝数变异的方法、系统和计算机可读介质 |
| CN111511914B (zh) | 2017-10-16 | 2023-11-17 | 豪夫迈·罗氏有限公司 | 减少PAPD5和PAPD7 mRNA的核酸分子用于治疗乙型肝炎感染 |
| CN112055749A (zh) | 2018-04-05 | 2020-12-08 | 豪夫迈·罗氏有限公司 | Fubp1抑制剂用于治疗乙型肝炎病毒感染的用途 |
| CA3247235A1 (en) | 2018-07-03 | 2025-11-29 | F. Hoffmann-La Roche Ag | Oligonucleotides for modulating tau expression |
| CA3106288A1 (en) | 2018-07-13 | 2020-01-16 | F.Hoffmann-La Roche Ag | Oligonucleotides for modulating rtel1 expression |
| MY201997A (en) | 2018-08-13 | 2024-03-28 | Alnylam Pharmaceuticals Inc | Hepatitis b virus (hbv) dsrna agent compositions and methods of use thereof |
| WO2021122921A1 (en) | 2019-12-19 | 2021-06-24 | F. Hoffmann-La Roche Ag | Use of cops3 inhibitors for treating hepatitis b virus infection |
| WO2021122869A1 (en) | 2019-12-19 | 2021-06-24 | F. Hoffmann-La Roche Ag | Use of scamp3 inhibitors for treating hepatitis b virus infection |
| WO2021122735A1 (en) | 2019-12-19 | 2021-06-24 | F. Hoffmann-La Roche Ag | Use of sept9 inhibitors for treating hepatitis b virus infection |
| CN114867856A (zh) | 2019-12-19 | 2022-08-05 | 豪夫迈·罗氏有限公司 | Saraf抑制剂用于治疗乙型肝炎病毒感染的用途 |
| WO2021122910A1 (en) | 2019-12-19 | 2021-06-24 | F. Hoffmann-La Roche Ag | Use of sbds inhibitors for treating hepatitis b virus infection |
| JP2023538630A (ja) | 2020-08-21 | 2023-09-08 | エフ． ホフマン－ラ ロシュ アーゲー | Ｂ型肝炎ウイルス感染症を処置するためのａ１ｃｆ阻害剤の使用 |
| TW202246500A (zh) | 2021-02-02 | 2022-12-01 | 瑞士商赫孚孟拉羅股份公司 | 用於抑制 ｒｔｅｌ１ 表現之增強型寡核苷酸 |
| WO2023111210A1 (en) | 2021-12-17 | 2023-06-22 | F. Hoffmann-La Roche Ag | Combination of oligonucleotides for modulating rtel1 and fubp1 |
Family Cites Families (47)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5643771A (en) | 1980-05-19 | 1997-07-01 | The Board Of Trustees Of The Leland Stanford Junior University | Non-reverting live bacterial vaccines |
| US4897355A (en) | 1985-01-07 | 1990-01-30 | Syntex (U.S.A.) Inc. | N[ω,(ω-1)-dialkyloxy]- and N-[ω,(ω-1)-dialkenyloxy]-alk-1-yl-N,N,N-tetrasubstituted ammonium lipids and uses therefor |
| JP2917998B2 (ja) | 1988-02-05 | 1999-07-12 | ホワイトヘッド・インスティチュート・フォー・バイオメディカル・リサーチ | 修飾された肝細胞およびその用途 |
| US5703055A (en) | 1989-03-21 | 1997-12-30 | Wisconsin Alumni Research Foundation | Generation of antibodies through lipid mediated DNA delivery |
| US5279833A (en) | 1990-04-04 | 1994-01-18 | Yale University | Liposomal transfection of nucleic acids into animal cells |
| US5264618A (en) | 1990-04-19 | 1993-11-23 | Vical, Inc. | Cationic lipids for intracellular delivery of biologically active molecules |
| JPH05507203A (ja) | 1990-06-18 | 1993-10-21 | アメリカ合衆国 | 真核性発現ベクター系 |
| US5283185A (en) | 1991-08-28 | 1994-02-01 | University Of Tennessee Research Corporation | Method for delivering nucleic acids into cells |
| US20030206887A1 (en) * | 1992-05-14 | 2003-11-06 | David Morrissey | RNA interference mediated inhibition of hepatitis B virus (HBV) using short interfering nucleic acid (siNA) |
| US5593972A (en) | 1993-01-26 | 1997-01-14 | The Wistar Institute | Genetic immunization |
| US5739118A (en) | 1994-04-01 | 1998-04-14 | Apollon, Inc. | Compositions and methods for delivery of genetic material |
| EP0759979A4 (en) | 1994-05-10 | 1999-10-20 | Gen Hospital Corp | THE ANTISENSE INHIBITION OF HEPATITIS C VIRUS |
| JPH07303485A (ja) | 1994-05-13 | 1995-11-21 | Tonen Corp | Ｈｃｖアンチセンスｒｎａ、それを含む発現ベクター、及び該ｒｎａ又は発現ベクターを含むｈｃｖ関連疾患治療剤 |
| US5646262A (en) * | 1994-07-28 | 1997-07-08 | Georgetown University | Antisense oligonucleotides against hepatitis B viral replication |
| US5837533A (en) | 1994-09-28 | 1998-11-17 | American Home Products Corporation | Complexes comprising a nucleic acid bound to a cationic polyamine having an endosome disruption agent |
| US5571026A (en) | 1994-12-09 | 1996-11-05 | Kcs Industries, Inc. | Flat mount electrode socket |
| US6057153A (en) | 1995-01-13 | 2000-05-02 | Yale University | Stabilized external guide sequences |
| US5877159A (en) | 1995-05-03 | 1999-03-02 | University Of Maryland At Baltimore | Method for introducing and expressing genes in animal cells and live invasive bacterial vectors for use in the same |
| US5932241A (en) | 1995-06-07 | 1999-08-03 | Valentis, Incorporated | Cationic lipid DNA complexes for gene targeting |
| US5824538A (en) | 1995-09-06 | 1998-10-20 | The United States Of America As Represented By The Secretary Of The Army | Shigella vector for delivering DNA to a mammalian cell |
| US5843770A (en) * | 1996-03-11 | 1998-12-01 | The Immune Response Corporation | Antisense constructs directed against viral post-transcriptional regulatory sequences |
| US5877162A (en) * | 1996-03-14 | 1999-03-02 | Innovir Laboratories, Inc. | Short external guide sequences |
| US6610478B1 (en) * | 1996-08-16 | 2003-08-26 | Yale University | Phenotypic conversion of cells mediated by external guide sequences |
| US5981274A (en) | 1996-09-18 | 1999-11-09 | Tyrrell; D. Lorne J. | Recombinant hepatitis virus vectors |
| US6217900B1 (en) | 1997-04-30 | 2001-04-17 | American Home Products Corporation | Vesicular complexes and methods of making and using the same |
| DE19725803C1 (de) * | 1997-06-18 | 1999-02-11 | Deutsches Krebsforsch | HBV-gerichtete Antisense-Nukleinsäuren |
| WO1999037805A1 (en) | 1998-01-27 | 1999-07-29 | Cytocell Limited | Method for detection of nucleic acid target sequences involving in vitro transcription from an rna promoter |
| EP1027074A1 (en) | 1997-10-28 | 2000-08-16 | American Home Products Corporation | Compositions and methods for delivery of genetic material |
| US6506559B1 (en) | 1997-12-23 | 2003-01-14 | Carnegie Institute Of Washington | Genetic inhibition by double-stranded RNA |
| EP1063963A1 (en) | 1998-03-16 | 2001-01-03 | The Procter & Gamble Company | Method of reducing cellulite in mammalian skin |
| BR0009884A (pt) | 1999-04-21 | 2002-01-08 | American Home Prod | Processos e composições para a inibição da função das sequências de polinucleotìdeos |
| US6533250B2 (en) | 1999-10-15 | 2003-03-18 | W. Eugene Arthur | Energy dissipating system for a concrete roadway barrier |
| WO2003070918A2 (en) | 2002-02-20 | 2003-08-28 | Ribozyme Pharmaceuticals, Incorporated | Rna interference by modified short interfering nucleic acid |
| KR20080023768A (ko) | 2000-03-30 | 2008-03-14 | 화이트헤드 인스티튜트 포 바이오메디칼 리서치 | Ｒｎａ 간섭의 ｒｎａ 서열 특이적인 매개체 |
| US7439016B1 (en) | 2000-06-15 | 2008-10-21 | Digene Corporation | Detection of nucleic acids by type-specific hybrid capture method |
| US6680059B2 (en) * | 2000-08-29 | 2004-01-20 | Tripep Ab | Vaccines containing ribavirin and methods of use thereof |
| US6443403B1 (en) | 2000-09-11 | 2002-09-03 | Panduit Corp. | Cable routing clamp and method of application |
| JP2002335968A (ja) * | 2001-05-16 | 2002-11-26 | Kokuritsu Iyakuhin Shokuhin Eisei Kenkyusho | 新規転写因子、その遺伝子及びその結合ｄｎａ配列 |
| CA2921821A1 (en) | 2001-07-12 | 2003-01-23 | University Of Massachusetts | In vivo production of small interfering rnas that mediate gene silencing |
| AU2002321859A1 (en) | 2001-08-03 | 2003-02-24 | Michael Van Der Sleesen | Protective garment |
| US7103761B2 (en) | 2001-08-07 | 2006-09-05 | Hewlett-Packard Development Company, Lp. | Server system with multiple management user interfaces |
| US6673661B1 (en) | 2002-12-20 | 2004-01-06 | Taiwan Semiconductor Manufacturing Co., Ltd. | Self-aligned method for forming dual gate thin film transistor (TFT) device |
| EP1591524A4 (en) | 2003-01-24 | 2007-12-26 | Tokyo Metropolitan Org Med Res | OLIGORIBONUCLEOTIDE OR PEPTIDIC NUCLEIC ACID, THE BZW. THE FUNCTION OF THE HEPATITIS C-VIRUS HEMMT |
| CN1257284C (zh) | 2003-03-05 | 2006-05-24 | 北京博奥生物芯片有限责任公司 | 一种体外阻断乙肝病毒表达的方法 |
| JP4980716B2 (ja) | 2003-06-12 | 2012-07-18 | アルナイラム ファーマシューティカルズ， インコーポレイテッド | 遺伝子サイレンシングに有用な保存されたｈｂｖ及びｈｃｖ配列 |
| EP1784492B1 (en) * | 2004-08-23 | 2010-10-06 | Alnylam Pharmaceuticals, Inc. | Multiple rna polymerase iii promoter expression constructs |
| JP2015086965A (ja) | 2013-10-31 | 2015-05-07 | 株式会社エクセディ | フライホイール組立体 |
-
2004
- 2004-06-10 JP JP2006533810A patent/JP4980716B2/ja not_active Expired - Fee Related
- 2004-06-10 CA CA3040025A patent/CA3040025C/en not_active Expired - Lifetime
- 2004-06-10 CA CA2528510A patent/CA2528510C/en not_active Expired - Lifetime
- 2004-06-10 EP EP10180048.0A patent/EP2270162B1/en not_active Expired - Lifetime
- 2004-06-10 WO PCT/US2004/019229 patent/WO2005014806A2/en not_active Ceased
- 2004-06-10 SI SI200432456T patent/SI2270162T1/sl unknown
- 2004-06-10 EP EP04776661A patent/EP1631670B1/en not_active Expired - Lifetime
- 2004-06-10 EP EP10180047A patent/EP2284268A3/en not_active Withdrawn
- 2004-06-10 DK DK10180048.0T patent/DK2270162T3/en active
- 2004-06-10 CN CNA2004800228949A patent/CN1836042A/zh active Pending
- 2004-06-10 SG SG2007044373A patent/SG173218A1/en unknown
- 2004-06-10 BR BRPI0411219-9A patent/BRPI0411219A/pt not_active Application Discontinuation
- 2004-06-10 US US10/560,377 patent/US8350021B2/en not_active Expired - Fee Related
- 2004-06-10 EP EP18192425.9A patent/EP3470518A1/en active Pending
- 2004-06-10 AU AU2004263832A patent/AU2004263832B2/en not_active Expired
- 2004-06-10 HU HUE10180048A patent/HUE042261T2/hu unknown
-
2005
- 2005-11-30 IL IL172268A patent/IL172268A0/en unknown
-
2011
- 2011-07-04 JP JP2011148461A patent/JP5593279B2/ja not_active Expired - Lifetime
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