JP4980716B2 - 遺伝子サイレンシングに有用な保存されたｈｂｖ及びｈｃｖ配列 - Google Patents

遺伝子サイレンシングに有用な保存されたｈｂｖ及びｈｃｖ配列 Download PDF

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JP4980716B2
JP4980716B2 JP2006533810A JP2006533810A JP4980716B2 JP 4980716 B2 JP4980716 B2 JP 4980716B2 JP 2006533810 A JP2006533810 A JP 2006533810A JP 2006533810 A JP2006533810 A JP 2006533810A JP 4980716 B2 JP4980716 B2 JP 4980716B2
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seq
sequence
hbv
rna
expression
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JP2007503474A5 (enExample
JP2007503474A (ja
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キャサリン・ジェイ・パチュク
シー・サティシュチャンドラン
ビンセント・アール・ズロースキ・ジュニア
リアット・ミンツ
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Alnylam Pharmaceuticals Inc
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    • C—CHEMISTRY; METALLURGY
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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C12N15/1131—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
    • A61P31/22—Antivirals for DNA viruses for herpes viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/10—Type of nucleic acid
    • C12N2310/11—Antisense
    • C12N2310/111—Antisense spanning the whole gene, or a large part of it
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/10—Type of nucleic acid
    • C12N2310/14—Type of nucleic acid interfering nucleic acids [NA]
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/50—Physical structure
    • C12N2310/53—Physical structure partially self-complementary or closed
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/50—Physical structure
    • C12N2310/53—Physical structure partially self-complementary or closed
    • C12N2310/531—Stem-loop; Hairpin

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  • Health & Medical Sciences (AREA)
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  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
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  • Microbiology (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Saccharide Compounds (AREA)
JP2006533810A 2003-06-12 2004-06-10 遺伝子サイレンシングに有用な保存されたｈｂｖ及びｈｃｖ配列 Expired - Fee Related JP4980716B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US47807603P 2003-06-12 2003-06-12
US60/478,076 2003-06-12
PCT/US2004/019229 WO2005014806A2 (en) 2003-06-12 2004-06-10 Conserved hbv and hcv sequences useful for gene silencing

Related Child Applications (1)

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JP2011148461A Division JP5593279B2 (ja) 2003-06-12 2011-07-04 遺伝子サイレンシングに有用な保存されたｈｂｖ及びｈｃｖ配列

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JP2007503474A JP2007503474A (ja) 2007-02-22
JP2007503474A5 JP2007503474A5 (enExample) 2007-07-26
JP4980716B2 true JP4980716B2 (ja) 2012-07-18

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JP2011148461A Expired - Lifetime JP5593279B2 (ja) 2003-06-12 2011-07-04 遺伝子サイレンシングに有用な保存されたｈｂｖ及びｈｃｖ配列

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US (1) US8350021B2 (enExample)
EP (4) EP1631670B1 (enExample)
JP (2) JP4980716B2 (enExample)
CN (1) CN1836042A (enExample)
AU (1) AU2004263832B2 (enExample)
BR (1) BRPI0411219A (enExample)
CA (2) CA2528510C (enExample)
DK (1) DK2270162T3 (enExample)
HU (1) HUE042261T2 (enExample)
IL (1) IL172268A0 (enExample)
SG (1) SG173218A1 (enExample)
SI (1) SI2270162T1 (enExample)
WO (1) WO2005014806A2 (enExample)

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TW202246500A (zh) 2021-02-02 2022-12-01 瑞士商赫孚孟拉羅股份公司 用於抑制 ｒｔｅｌ１ 表現之增強型寡核苷酸
CN119095603A (zh) 2021-12-17 2024-12-06 豪夫迈·罗氏有限公司 用于调节rtel1和fubp1的寡核苷酸的组合

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US20080070854A1 (en) 2008-03-20
JP5593279B2 (ja) 2014-09-17
JP2011224013A (ja) 2011-11-10
AU2004263832A1 (en) 2005-02-17
EP2284268A3 (en) 2012-05-30
EP1631670A2 (en) 2006-03-08
EP2270162B1 (en) 2018-10-03
HUE042261T2 (hu) 2019-06-28
JP2007503474A (ja) 2007-02-22
IL172268A0 (en) 2006-04-10
SI2270162T1 (sl) 2019-03-29
AU2004263832B2 (en) 2010-07-01
CA3040025A1 (en) 2005-02-17
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EP2284268A2 (en) 2011-02-16
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WO2005014806A3 (en) 2005-12-01
EP3470518A1 (en) 2019-04-17
EP1631670B1 (en) 2012-08-08
BRPI0411219A (pt) 2006-07-18
EP2270162A2 (en) 2011-01-05
CN1836042A (zh) 2006-09-20
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