|
JP4527984B2
(ja)
|
2002-02-01 |
2010-08-18 |
ライフ テクノロジーズ コーポレーション |
増強された効力を有するオリゴヌクレオチド組成物
|
|
US20060009409A1
(en)
|
2002-02-01 |
2006-01-12 |
Woolf Tod M |
Double-stranded oligonucleotides
|
|
EP1572902B1
(en)
|
2002-02-01 |
2014-06-11 |
Life Technologies Corporation |
HIGH POTENCY siRNAS FOR REDUCING THE EXPRESSION OF TARGET GENES
|
|
US7892793B2
(en)
*
|
2002-11-04 |
2011-02-22 |
University Of Massachusetts |
Allele-specific RNA interference
|
|
US9879266B2
(en)
|
2002-11-14 |
2018-01-30 |
Thermo Fisher Scientific Inc. |
Methods and compositions for selecting siRNA of improved functionality
|
|
US9228186B2
(en)
|
2002-11-14 |
2016-01-05 |
Thermo Fisher Scientific Inc. |
Methods and compositions for selecting siRNA of improved functionality
|
|
ATE485394T1
(de)
*
|
2003-06-02 |
2010-11-15 |
Univ Massachusetts |
Verfahren und zusammensetzungen zur verbesserung der wirksamkeit und spezifität von fnai
|
|
EP3502252B1
(en)
|
2003-06-02 |
2023-04-05 |
University of Massachusetts |
Methods and compositions for controlling efficacy of rna silencing
|
|
US7750144B2
(en)
|
2003-06-02 |
2010-07-06 |
University Of Massachusetts |
Methods and compositions for enhancing the efficacy and specificity of RNA silencing
|
|
DK2821085T3
(da)
|
2003-09-12 |
2020-08-03 |
Univ Massachusetts |
Rna-interferens til behandling af "gain-of-function"-forstyrrelser
|
|
US8680063B2
(en)
|
2003-09-12 |
2014-03-25 |
University Of Massachusetts |
RNA interference for the treatment of gain-of-function disorders
|
|
US20060134787A1
(en)
|
2004-12-22 |
2006-06-22 |
University Of Massachusetts |
Methods and compositions for enhancing the efficacy and specificity of single and double blunt-ended siRNA
|
|
JP5243789B2
(ja)
|
2004-03-15 |
2013-07-24 |
シティ・オブ・ホープ |
二本鎖rnaによる遺伝子発現の特異的阻害のための方法及び組成物
|
|
US20070265220A1
(en)
*
|
2004-03-15 |
2007-11-15 |
City Of Hope |
Methods and compositions for the specific inhibition of gene expression by double-stranded RNA
|
|
WO2006085987A2
(en)
|
2004-07-09 |
2006-08-17 |
University Of Iowa Research Foundation |
Rna interference in respiratory epitheial cells
|
|
US20060142228A1
(en)
*
|
2004-12-23 |
2006-06-29 |
Ambion, Inc. |
Methods and compositions concerning siRNA's as mediators of RNA interference
|
|
GB2421948A
(en)
*
|
2004-12-30 |
2006-07-12 |
Ist Superiore Sanita |
Retrotransposon inhibition to treat cancer
|
|
US20070213293A1
(en)
*
|
2005-04-08 |
2007-09-13 |
Nastech Pharmaceutical Company Inc. |
Rnai therapeutic for respiratory virus infection
|
|
US8252756B2
(en)
|
2005-06-14 |
2012-08-28 |
Northwestern University |
Nucleic acid functionalized nanoparticles for therapeutic applications
|
|
US20070105803A1
(en)
*
|
2005-08-18 |
2007-05-10 |
Muthiah Manoharan |
Methods and compositions for treating neurological disease
|
|
US20080124365A1
(en)
*
|
2006-05-24 |
2008-05-29 |
Genolution Pharmaceuticals, Inc. |
Innate immune response inducer
|
|
US8598333B2
(en)
*
|
2006-05-26 |
2013-12-03 |
Alnylam Pharmaceuticals, Inc. |
SiRNA silencing of genes expressed in cancer
|
|
WO2008017473A2
(en)
|
2006-08-08 |
2008-02-14 |
Gunther Hartmann |
Structure and use of 5' phosphate oligonucleotides
|
|
US9074205B2
(en)
*
|
2006-10-18 |
2015-07-07 |
Marina Biotech, Inc. |
Nicked or gapped nucleic acid molecules and uses thereof
|
|
CA2691066C
(en)
|
2007-02-09 |
2018-07-31 |
Northwestern University |
Particles for detecting intracellular targets
|
|
JP5311854B2
(ja)
|
2007-03-23 |
2013-10-09 |
キヤノン株式会社 |
電子写真画像形成装置、現像装置、及び、カップリング部材
|
|
WO2008143774A2
(en)
*
|
2007-05-01 |
2008-11-27 |
University Of Massachusetts |
Methods and compositions for locating snp heterozygosity for allele specific diagnosis and therapy
|
|
AU2013273719B2
(en)
*
|
2007-05-22 |
2016-04-14 |
Arcturus Therapeutics, Inc. |
UNA amidites for therapeutic oligomers
|
|
PL2162538T3
(pl)
*
|
2007-05-22 |
2016-10-31 |
|
Oligomery do zastosowań terapeutycznych
|
|
DK2160464T3
(da)
|
2007-05-30 |
2014-08-04 |
Univ Northwestern |
Nukleinsyrefunktionaliserede nanopartikler til terapeutiske anvendelser
|
|
US20090036396A1
(en)
|
2007-08-03 |
2009-02-05 |
Alcon Research, Ltd. |
RNAi-RELATED INHIBITION OF TNFalpha SIGNALING PATHWAY FOR TREATMENT OF OCULAR ANGIOGENESIS
|
|
WO2009029688A2
(en)
*
|
2007-08-27 |
2009-03-05 |
Boston Biomedical, Inc. |
Compositions of asymmetric interfering rna and uses thereof
|
|
DK2195428T3
(en)
|
2007-09-19 |
2014-03-03 |
Applied Biosystems Llc |
SIRNA SEQUENCE-INDEPENDENT MODIFICATION FORMS TO REDUCE TARGET-FAILING PHENOTYPIC EFFECTS OF RNAI, AND STABILIZED FORMS THEREOF
|
|
TW200927177A
(en)
*
|
2007-10-24 |
2009-07-01 |
Nat Inst Of Advanced Ind Scien |
Lipid-modified double-stranded RNA having potent RNA interference effect
|
|
US8030290B2
(en)
|
2007-12-07 |
2011-10-04 |
City Of Hope |
Cell-type specific aptamer-siRNA delivery system for HIV-1 Therapy
|
|
US9738680B2
(en)
|
2008-05-21 |
2017-08-22 |
Rheinische Friedrich-Wilhelms-Universität Bonn |
5′ triphosphate oligonucleotide with blunt end and uses thereof
|
|
EP2315831A2
(en)
*
|
2008-08-05 |
2011-05-04 |
Marina Biotech, Inc. |
Nucleic acid compounds for inhibiting plk1 gene expression and uses thereof
|
|
WO2010021718A1
(en)
*
|
2008-08-19 |
2010-02-25 |
Nektar Therapeutics |
Complexes of small-interfering nucleic acids
|
|
PT2341943T
(pt)
*
|
2008-09-22 |
2019-02-06 |
Dicerna Pharmaceuticals Inc |
Composições e métodos para a inibição específica de expressão génica por dsrna que possui modificações
|
|
CN102281872A
(zh)
|
2008-11-24 |
2011-12-14 |
西北大学 |
多价rna纳米颗粒组合物
|
|
EP2370577B1
(en)
|
2008-12-03 |
2019-08-28 |
Arcturus Therapeutics, Inc. |
Usirna complexes
|
|
US11408003B2
(en)
|
2008-12-18 |
2022-08-09 |
Dicerna Pharmaceuticals, Inc. |
Extended dicer substrate agents and methods for the specific inhibition of gene expression
|
|
AU2009336191B2
(en)
*
|
2008-12-18 |
2017-08-24 |
Novo Nordisk A/S |
Extended dicer substrate agents and methods for the specific inhibition of gene expression
|
|
US20100233270A1
(en)
|
2009-01-08 |
2010-09-16 |
Northwestern University |
Delivery of Oligonucleotide-Functionalized Nanoparticles
|
|
WO2010093788A2
(en)
|
2009-02-11 |
2010-08-19 |
Dicerna Pharmaceuticals, Inc. |
Multiplex dicer substrate rna interference molecules having joining sequences
|
|
CN104651362A
(zh)
|
2009-04-03 |
2015-05-27 |
戴瑟纳制药公司 |
利用不对称双链rna特异性抑制kras的方法和组合物
|
|
EP2756845B1
(en)
|
2009-04-03 |
2017-03-15 |
Dicerna Pharmaceuticals, Inc. |
Methods and compositions for the specific inhibition of KRAS by asymmetric double-stranded RNA
|
|
WO2010141724A2
(en)
*
|
2009-06-03 |
2010-12-09 |
Dicerna Pharmaceuticals, Inc. |
Peptide dicer substrate agents and methods for their specific inhibition of gene expression
|
|
WO2010141933A1
(en)
*
|
2009-06-05 |
2010-12-09 |
Dicerna Pharmaceuticals, Inc. |
Specific inhibition of gene expression by nucleic acid containing a dicer substrate
|
|
CN107129998A
(zh)
|
2009-06-10 |
2017-09-05 |
淡马锡生命科学研究院有限公司 |
用于棉花中基因功能性分析的病毒诱导的基因沉默(vigs)
|
|
JP5766188B2
(ja)
|
2009-07-01 |
2015-08-19 |
プロチバ バイオセラピューティクス インコーポレイティッド |
固形腫瘍に治療剤を送達するための脂質製剤
|
|
US8716464B2
(en)
|
2009-07-20 |
2014-05-06 |
Thomas W. Geisbert |
Compositions and methods for silencing Ebola virus gene expression
|
|
WO2011032100A1
(en)
|
2009-09-11 |
2011-03-17 |
Government Of The U.S.A., As Represented By The Secretary, Department Of Health And Human Services |
Inhibitors of kshv vil6 and human il6
|
|
WO2011035065A1
(en)
|
2009-09-17 |
2011-03-24 |
Nektar Therapeutics |
Monoconjugated chitosans as delivery agents for small interfering nucleic acids
|
|
CA2775092A1
(en)
|
2009-09-23 |
2011-03-31 |
Protiva Biotherapeutics, Inc. |
Compositions and methods for silencing genes expressed in cancer
|
|
AU2010313154B2
(en)
|
2009-10-30 |
2016-05-12 |
Northwestern University |
Templated nanoconjugates
|
|
DK2509991T3
(en)
|
2009-12-09 |
2015-12-21 |
Nitto Denko Corp |
MODULATION OF HSP47 EXPRESSION
|
|
JP5257796B2
(ja)
*
|
2009-12-28 |
2013-08-07 |
株式会社村田製作所 |
固体電解コンデンサ素子及びその製造方法
|
|
WO2011109294A1
(en)
*
|
2010-03-01 |
2011-09-09 |
Dicerna Pharmaceuticals, Inc. |
Lipid delivery formulations
|
|
WO2011118739A1
(ja)
|
2010-03-26 |
2011-09-29 |
協和発酵キリン株式会社 |
新規修飾部位導入抗体および抗体フラグメント
|
|
WO2011133878A2
(en)
*
|
2010-04-22 |
2011-10-27 |
University Of Utah Research Foundation |
Compositions and methods for selectively producing sirna
|
|
EP2567952A4
(en)
|
2010-04-28 |
2015-11-25 |
Kyowa Hakko Kirin Co Ltd |
CATIONIC LIPID
|
|
EP2567951B1
(en)
|
2010-04-28 |
2018-09-19 |
Kyowa Hakko Kirin Co., Ltd. |
Cationic lipid
|
|
EP2591104A4
(en)
|
2010-07-06 |
2014-09-03 |
Dicerna Pharmaceuticals Inc |
METHOD AND COMPOSITIONS FOR SPECIFIC INHIBITION OF THE ANDROGEN RECEPTOR BY DOUBLE-STRUCTURED RNA
|
|
DK3587579T3
(da)
|
2010-07-06 |
2021-04-26 |
Dicerna Pharmaceuticals Inc |
Fremgangsmåder og sammensætninger til specifik hæmning af beta-catenin ved hjælp af dobbeltstrenget rna
|
|
WO2012051491A1
(en)
|
2010-10-14 |
2012-04-19 |
The United States Of America, As Represented By The Secretary National Institutes Of Health |
Compositions and methods for controlling neurotropic viral pathogenesis by micro-rna targeting
|
|
KR101937498B1
(ko)
|
2011-03-03 |
2019-04-10 |
쿠아크 파마수티칼스 인코퍼레이티드 |
폐 질환 및 손상을 치료하기 위한 조성물 및 방법
|
|
EP2508530A1
(en)
|
2011-03-28 |
2012-10-10 |
Rheinische Friedrich-Wilhelms-Universität Bonn |
Purification of triphosphorylated oligonucleotides using capture tags
|
|
US10196637B2
(en)
|
2011-06-08 |
2019-02-05 |
Nitto Denko Corporation |
Retinoid-lipid drug carrier
|
|
TWI658830B
(zh)
|
2011-06-08 |
2019-05-11 |
日東電工股份有限公司 |
Hsp47表現調控強化用類視色素脂質體
|
|
SG195304A1
(en)
|
2011-06-10 |
2013-12-30 |
Temasek Life Sciences Lab Ltd |
Genetic manipulation and expression systems for pucciniomycotina and ustilaginomycotina subphyla
|
|
CA2847698C
(en)
|
2011-09-14 |
2020-09-01 |
Northwestern University |
Nanoconjugates able to cross the blood-brain barrier
|
|
WO2013059496A1
(en)
|
2011-10-18 |
2013-04-25 |
Dicerna Pharmaceuticals, Inc. |
Amine cationic lipids and uses thereof
|
|
WO2013060856A2
(en)
*
|
2011-10-27 |
2013-05-02 |
Occlutech Holding Ag |
A medical implant for occluding an opening in a body and a method of producing such a medical implant
|
|
JP2013095755A
(ja)
|
2011-11-02 |
2013-05-20 |
Kyowa Hakko Kirin Co Ltd |
カチオン性脂質
|
|
KR20140111272A
(ko)
|
2011-12-12 |
2014-09-18 |
교와 핫꼬 기린 가부시키가이샤 |
양이온성 지질의 조합을 함유하는 지질 나노 입자
|
|
WO2013089151A1
(ja)
|
2011-12-12 |
2013-06-20 |
協和発酵キリン株式会社 |
カチオン性脂質を含有するドラッグデリバリーシステムのための脂質ナノ粒子
|
|
US9035039B2
(en)
|
2011-12-22 |
2015-05-19 |
Protiva Biotherapeutics, Inc. |
Compositions and methods for silencing SMAD4
|
|
EP3473611B1
(en)
|
2012-02-24 |
2021-10-20 |
Arbutus Biopharma Corporation |
Trialkyl cationic lipids and methods of use thereof
|
|
CN104797712B
(zh)
|
2012-04-19 |
2018-06-12 |
淡马锡生命科学研究院有限公司 |
提高棉纤维长度的方法
|
|
US9272016B2
(en)
|
2012-04-20 |
2016-03-01 |
University Of Iowa Research Foundation |
Methods to enhance RNAi oligonucleotide delivery to respiratory epithelial cells
|
|
TW201408625A
(zh)
|
2012-07-06 |
2014-03-01 |
Kyowa Hakko Kirin Co Ltd |
陽離子性脂質
|
|
EP3878962A1
(en)
*
|
2012-07-17 |
2021-09-15 |
Stelic Institute & Co. |
Mucosal healing promoter
|
|
WO2014018375A1
(en)
|
2012-07-23 |
2014-01-30 |
Xenon Pharmaceuticals Inc. |
Cyp8b1 and uses thereof in therapeutic and diagnostic methods
|
|
JP6336390B2
(ja)
|
2012-08-31 |
2018-06-06 |
協和発酵キリン株式会社 |
オリゴヌクレオチド
|
|
JP6374388B2
(ja)
|
2012-09-21 |
2018-08-15 |
インテンシティ セラピューティクス, インク.Intensity Therapeutics, Inc. |
癌の治療方法
|
|
EP2712870A1
(en)
|
2012-09-27 |
2014-04-02 |
Rheinische Friedrich-Wilhelms-Universität Bonn |
Novel RIG-I ligands and methods for producing them
|
|
WO2014055825A1
(en)
|
2012-10-04 |
2014-04-10 |
The United States Of America, As Represented By The Secretary, Department Of Health & Human Services |
A formulation of mycobacterial components as an adjuvant for inducing th17 responses
|
|
CA2893824A1
(en)
|
2012-12-14 |
2014-06-19 |
Dicerna Pharmaceuticals, Inc. |
Methods and compositions for the specific inhibition of ckap5 by double-stranded rna
|
|
WO2014113541A1
(en)
|
2013-01-16 |
2014-07-24 |
The United States Of America, As Represented By The Secretary, Department Of Health & Human Services |
Attenuated chlamydia vaccine
|
|
EP2961843A2
(en)
|
2013-02-28 |
2016-01-06 |
Arrowhead Research Corporation |
Organic compositions to treat epas1-related diseases
|
|
CN105142614A
(zh)
|
2013-03-14 |
2015-12-09 |
迪克纳制药公司 |
用于配制阴离子试剂的方法
|
|
US9546364B2
(en)
|
2013-03-15 |
2017-01-17 |
Carnegie Mellon University |
Synthetic lariat RNA for RNA interference
|
|
JP2016528887A
(ja)
|
2013-07-03 |
2016-09-23 |
ダイセルナ ファーマシューティカルズ, インコーポレイテッドDicerna Pharmaceuticals, Inc. |
二本鎖RNAによるα−1アンチトリプシンの特異的阻害のための方法及び組成物
|
|
US20150026358A1
(en)
*
|
2013-07-19 |
2015-01-22 |
Futurewei Technologies, Inc. |
Metadata Information Signaling And Carriage In Dynamic Adaptive Streaming Over Hypertext Transfer Protocol
|
|
JP6433001B2
(ja)
|
2013-08-07 |
2018-12-05 |
アローヘッド ファーマシューティカルズ インコーポレイテッド |
腫瘍細胞へのRNAiトリガーのインビボ送達のためのポリ結合体
|
|
US10150965B2
(en)
|
2013-12-06 |
2018-12-11 |
Dicerna Pharmaceuticals, Inc. |
Methods and compositions for the specific inhibition of transthyretin (TTR) by double-stranded RNA
|
|
DK3087184T3
(da)
|
2013-12-27 |
2019-07-29 |
Dicerna Pharmaceuticals Inc |
Fremgangsmåder og sammensætninger til specifik inhibering af glycolatoxidase (hao1) med dobbeltstrenget rna
|
|
CN105980560A
(zh)
|
2014-01-17 |
2016-09-28 |
协和发酵麒麟株式会社 |
抑制β2GPI表达的核酸
|
|
CA2946719C
(en)
|
2014-03-25 |
2023-09-26 |
Arcturus Therapeutics, Inc. |
Una oligomers having reduced off-target effects in gene silencing
|
|
EP3122365B1
(en)
|
2014-03-25 |
2023-05-03 |
Arcturus Therapeutics, Inc. |
Transthyretin allele selective una oligomers for gene silencing
|
|
US9856475B2
(en)
|
2014-03-25 |
2018-01-02 |
Arcturus Therapeutics, Inc. |
Formulations for treating amyloidosis
|
|
US9987299B2
(en)
|
2014-05-05 |
2018-06-05 |
University Of Iowa Research Foundation |
Methods of improving RNAi in well-differentiated airway epithelia
|
|
US10517890B2
(en)
|
2014-05-06 |
2019-12-31 |
The United States Of America, As Represented By The Secretary, Department Of Health And Human Services |
Triggering RNA interference with RNA-DNA and DNA-RNA nanoparticles
|
|
EP3154694B1
(en)
|
2014-06-13 |
2025-01-29 |
Children's Medical Center Corporation |
Products and methods to isolate mitochondria
|
|
TW201620526A
(zh)
|
2014-06-17 |
2016-06-16 |
愛羅海德研究公司 |
用於抑制α-1抗胰蛋白酶基因表現之組合物及方法
|
|
KR101670254B1
(ko)
*
|
2014-07-09 |
2016-10-28 |
서울대학교산학협력단 |
목적 유전자의 발현 억제 특이성이 증가된 siRNA 분자
|
|
JP6797108B2
(ja)
|
2014-08-19 |
2020-12-09 |
ノースウェスタン ユニバーシティ |
タンパク質/オリゴヌクレオチドコアシェルナノ粒子治療薬
|
|
JP2016071140A
(ja)
|
2014-09-30 |
2016-05-09 |
富士フイルム株式会社 |
ズームレンズおよび撮像装置
|
|
JOP20200115A1
(ar)
*
|
2014-10-10 |
2017-06-16 |
Alnylam Pharmaceuticals Inc |
تركيبات وطرق لتثبيط التعبير الجيني عن hao1 (حمض أوكسيداز هيدروكسيلي 1 (أوكسيداز جليكولات))
|
|
EP3204497B1
(en)
|
2014-10-10 |
2020-03-11 |
Dicerna Pharmaceuticals, Inc. |
Therapeutic inhibition of lactate dehydrogenase and agents therefor
|
|
WO2016064347A1
(en)
|
2014-10-22 |
2016-04-28 |
Temasek Life Sciences Laboratory Limited |
Terpene synthases from ylang ylang (cananga odorata var. fruticosa)
|
|
CA2968531A1
(en)
|
2014-11-21 |
2016-05-26 |
Northwestern University |
The sequence-specific cellular uptake of spherical nucleic acid nanoparticle conjugates
|
|
DK3234132T3
(da)
|
2014-12-15 |
2019-08-26 |
Dicerna Pharmaceuticals Inc |
Ligand-modificerede dobbeltstrengede nukleinsyrer
|
|
US10264976B2
(en)
|
2014-12-26 |
2019-04-23 |
The University Of Akron |
Biocompatible flavonoid compounds for organelle and cell imaging
|
|
US10036017B2
(en)
|
2015-02-17 |
2018-07-31 |
Dicerna Pharmaceuticals, Inc. |
Methods and compositions for the specific inhibition of complement component 5(C5) by double-stranded RNA
|
|
US9803201B2
(en)
|
2015-03-17 |
2017-10-31 |
Arrowhead Pharmaceuticals, Inc. |
Disulfide-containing alkyne linking agents
|
|
EP3271482A4
(en)
|
2015-03-17 |
2019-02-13 |
Arrowhead Pharmaceuticals, Inc. |
COMPOSITIONS AND METHODS FOR INHIBITING THE GENE EXPRESSION OF FACTOR XII
|
|
WO2016161299A1
(en)
|
2015-04-01 |
2016-10-06 |
Arcturus Therapeutics, Inc. |
Therapeutic una oligomers and uses thereof
|
|
WO2016183009A2
(en)
|
2015-05-08 |
2016-11-17 |
Dicerna Pharmaceuticals, Inc. |
Methods and compositions for the specific inhibition of antithrombin 3 (at3) by double-stranded rna
|
|
SG11201708602XA
(en)
|
2015-05-29 |
2017-12-28 |
Arrowhead Pharmaceuticals Inc |
Biologically cleavable tetrapeptide linking agents
|
|
EA201792103A1
(ru)
|
2015-05-29 |
2018-06-29 |
Эрроухэд Фармасьютикалз, Инк. |
Композиции и способы для ингибирования экспрессии генов hif2альфа
|
|
WO2017015671A1
(en)
|
2015-07-23 |
2017-01-26 |
Arcturus Therapeutics, Inc. |
Compositions for treating amyloidosis
|
|
EP3332007A4
(en)
|
2015-08-07 |
2019-07-17 |
Arrowhead Pharmaceuticals, Inc. |
RNAi Therapy Against Infection with Hepatitis B Virus
|
|
JOP20210043A1
(ar)
|
2015-10-01 |
2017-06-16 |
Arrowhead Pharmaceuticals Inc |
تراكيب وأساليب لتثبيط تعبير جيني للـ lpa
|
|
WO2017095946A1
(en)
|
2015-11-30 |
2017-06-08 |
Flagship Pioneering, Inc. |
Methods and compositions relating to chondrisomes
|
|
BR112018008344A2
(pt)
|
2015-12-13 |
2018-10-30 |
Nitto Denko Corp |
molécula de ácido nucleico, composição farmacêutica, vetor ou célula, método para prevenir, tratar ou melhorar uma doença, e, uso de uma composição
|
|
JP6774965B2
(ja)
|
2015-12-25 |
2020-10-28 |
協和キリン株式会社 |
カチオン性脂質としての化合物
|
|
CN105462932A
(zh)
*
|
2015-12-29 |
2016-04-06 |
同济大学苏州研究院 |
一种采用慢病毒技术构建的抗肿瘤迁移药物筛选细胞模型及其应用方法
|
|
EP3402490B1
(en)
|
2016-01-15 |
2022-06-01 |
The Children's Medical Center Corporation |
Therapeutic use of mitochondria and combined mitochondrial agents
|
|
MY200875A
(en)
|
2016-02-25 |
2024-01-20 |
Applied Biological Laboratories Inc |
Compositions and methods for protecting against airborne pathogens and irritants
|
|
US12447166B2
(en)
|
2016-02-25 |
2025-10-21 |
Applied Biological Laboratories, Inc. |
Compositions and methods for protecting against airborne pathogens and irritants
|
|
MA45470A
(fr)
|
2016-04-01 |
2019-02-06 |
Avidity Biosciences Llc |
Acides nucléiques kras et leurs utilisations
|
|
MA45349A
(fr)
|
2016-04-01 |
2019-02-06 |
Avidity Biosciences Llc |
Acides nucléiques egfr et leurs utilisations
|
|
MA45328A
(fr)
|
2016-04-01 |
2019-02-06 |
Avidity Biosciences Llc |
Compositions acide nucléique-polypeptide et utilisations de celles-ci
|
|
MA45469A
(fr)
|
2016-04-01 |
2019-02-06 |
Avidity Biosciences Llc |
Acides nucléiques de bêta-caténine et leurs utilisations
|
|
CN107333099B
(zh)
*
|
2016-04-28 |
2019-11-19 |
瑞昱半导体股份有限公司 |
具有无线中继功能的网络摄影机
|
|
US11091795B2
(en)
|
2016-07-11 |
2021-08-17 |
Arizona Board Of Regents On Behalf Of The University Of Arizona |
Compositions and methods for diagnosing and treating arrhythmias
|
|
JOP20170161A1
(ar)
|
2016-08-04 |
2019-01-30 |
Arrowhead Pharmaceuticals Inc |
عوامل RNAi للعدوى بفيروس التهاب الكبد ب
|
|
TW202436621A
(zh)
|
2017-01-10 |
2024-09-16 |
美商愛羅海德製藥公司 |
α-1抗胰蛋白酶 (AAT) RNAi 藥劑、包含AAT RNAi 藥劑之組合物及使用方法
|
|
US11241436B2
(en)
|
2017-01-25 |
2022-02-08 |
Northwestern University |
Autophagy inducers for treatment of CNS conditions
|
|
JPWO2018164186A1
(ja)
|
2017-03-09 |
2020-01-09 |
協和キリン株式会社 |
Masp2の発現を抑制する核酸
|
|
US11512313B2
(en)
|
2017-04-03 |
2022-11-29 |
The United States Of America, As Represented By The Secretary, Department Of Health And Human Services |
Functionally-interdependent shape switching nucleic acid nanoparticles
|
|
EP3617314B1
(en)
*
|
2017-04-28 |
2023-02-15 |
Kyowa Kirin Co., Ltd. |
Oligonucleotide derivative or salt thereof
|
|
WO2018209270A1
(en)
|
2017-05-11 |
2018-11-15 |
Northwestern University |
Adoptive cell therapy using spherical nucleic acids (snas)
|
|
TW201903149A
(zh)
|
2017-05-31 |
2019-01-16 |
日商協和醱酵麒麟有限公司 |
抑制apcs之表現的核酸
|
|
US20200123203A1
(en)
|
2017-06-13 |
2020-04-23 |
Flagship Pioneering Innovations V, Inc. |
Compositions comprising curons and uses thereof
|
|
EP3651775A4
(en)
|
2017-07-13 |
2021-04-07 |
Alnylam Pharmaceuticals, Inc. |
METHOD FOR INHIBITION OF HAO1 (HYDROXYIC ACID OXIDASE-1 (GLYCOLATE OXIDASE) GENE EXPRESSION
|
|
US11633365B2
(en)
|
2017-08-04 |
2023-04-25 |
Kyowa Kirin Co., Ltd. |
Nucleic acid-containing lipid nanoparticle
|
|
KR20230169413A
(ko)
|
2017-10-13 |
2023-12-15 |
노보 노르디스크 헬스 케어 악티엔게젤샤프트 |
Ldha의 발현을 억제하기 위한 방법 및 조성물
|
|
US10815484B2
(en)
|
2017-11-22 |
2020-10-27 |
The Regents Of The University Of Michigan |
Compositions and methods for treating cancer
|
|
WO2019113393A1
(en)
|
2017-12-06 |
2019-06-13 |
Avidity Biosciences Llc |
Compositions and methods of treating muscle atrophy and myotonic dystrophy
|
|
MX2020006150A
(es)
|
2017-12-15 |
2020-11-11 |
Flagship Pioneering Innovations Vi Llc |
Composiciones que comprenden polirribonucleotidos circulares y usos de las mismas.
|
|
US11746151B2
(en)
|
2018-04-13 |
2023-09-05 |
The Regents Of The University Of Michigan |
Compositions and methods for treating cancer
|
|
PT3880212T
(pt)
|
2018-11-16 |
2024-02-08 |
Nitto Denko Corp |
Formulação e métodos de administração de rna de interferência para tumores malignos
|
|
KR20210098477A
(ko)
|
2018-11-30 |
2021-08-10 |
쿄와 기린 가부시키가이샤 |
핵산 복합체
|
|
CA3120580A1
(en)
|
2019-01-09 |
2020-07-16 |
Arrowhead Pharmaceuticals, Inc. |
Rnai agents for inhibiting expression of hif-2 alpha (epas1), compositions thereof, and methods of use
|
|
US12215382B2
(en)
|
2019-03-01 |
2025-02-04 |
The General Hospital Corporation |
Liver protective MARC variants and uses thereof
|
|
EP3946466A2
(en)
|
2019-03-25 |
2022-02-09 |
Flagship Pioneering Innovations VI, LLC |
Compositions comprising modified circular polyribonucleotides and uses thereof
|
|
MX2021011928A
(es)
|
2019-03-29 |
2022-01-04 |
Dicerna Pharmaceuticals Inc |
Composiciones y metodos para el tratamiento de enfermedades o trastornos asociados con kras.
|
|
BR112022003861A2
(pt)
|
2019-08-30 |
2022-05-24 |
Dicerna Pharmaceuticals Inc |
Ácidos nucleicos ligando-2'-modificados, síntese dos mesmos, e intermediários para os mesmos
|
|
CN114729376A
(zh)
|
2019-09-23 |
2022-07-08 |
欧米茄治疗公司 |
用于调节肝细胞核因子4α(HNF4α)基因表达的组合物和方法
|
|
CA3147641A1
(en)
|
2019-09-23 |
2021-04-01 |
Omega Therapeutics, Inc. |
Compositions and methods for modulating apolipoprotein b (apob) gene expression
|
|
US20230056569A1
(en)
|
2019-11-22 |
2023-02-23 |
Alnylam Pharmaceuticals, Inc. |
Ataxin3 (atxn3) rnai agent compositions and methods of use thereof
|
|
EP4096682A1
(en)
|
2020-01-29 |
2022-12-07 |
Flagship Pioneering Innovations VI, LLC |
Compositions for translation and methods of use thereof
|
|
JP2023517326A
(ja)
|
2020-03-11 |
2023-04-25 |
オメガ セラピューティクス, インコーポレイテッド |
フォークヘッドボックスp3(foxp3)遺伝子発現をモジュレートするための組成物および方法
|
|
TW202144572A
(zh)
|
2020-03-19 |
2021-12-01 |
美商亞維代堤生物科學公司 |
治療臉肩胛肱骨肌肉失養症之組合物及方法
|
|
MX2023002041A
(es)
|
2020-08-20 |
2023-04-27 |
A2 Biotherapeutics Inc |
Composiciones y métodos para tratar cánceres positivos para mesotelina.
|
|
EP4097486A4
(en)
|
2020-08-20 |
2023-09-06 |
A2 Biotherapeutics, Inc. |
COMPOSITIONS AND METHODS OF TREATMENT OF POSITIVE CANCERS AT CEACAM
|
|
LT4058474T
(lt)
|
2020-08-20 |
2024-08-26 |
A2 Biotherapeutics, Inc. |
Kompozicijos ir būdai, skirti gydyti egfr atžvilgiu teigiamas vėžio formas
|
|
EP4259134A4
(en)
|
2020-12-09 |
2024-10-30 |
The Regents Of The University Of Michigan |
Compositions and methods for treating wnt-driven cancer
|
|
IL303892A
(en)
|
2020-12-23 |
2023-08-01 |
Flagship Pioneering Innovations V Inc |
In vitro assembly of RNA-encapsulating enalavirus capsids
|
|
CA3207958A1
(en)
|
2021-02-16 |
2022-08-25 |
Julyun OH |
Compositions and methods for treating her2 positive cancers
|
|
CN117500819A
(zh)
|
2021-04-09 |
2024-02-02 |
相互药工株式会社 |
脂质和组合物
|
|
WO2022263931A2
(en)
|
2021-06-17 |
2022-12-22 |
Oslo Universitetssykehus Hf |
Compositions and methods for treating cancer
|
|
EP4367242A2
(en)
|
2021-07-07 |
2024-05-15 |
Omega Therapeutics, Inc. |
Compositions and methods for modulating secreted frizzled receptor protein 1 (sfrp1) gene expression
|
|
JP2024532019A
(ja)
|
2021-08-25 |
2024-09-05 |
ノボ ノルディスク エー/エス |
アルファ-1アンチトリプシン発現を阻害するための組成物及び方法
|
|
EP4419081A1
(en)
|
2021-10-22 |
2024-08-28 |
Sail Biomedicines, Inc. |
Mrna vaccine composition
|
|
WO2023092102A1
(en)
|
2021-11-19 |
2023-05-25 |
Sanegene Bio Usa Inc. |
Double stranded rna targeting angiopoietin-like 3 (angptl-3) and methods of use thereof
|
|
CN118488834A
(zh)
|
2021-11-23 |
2024-08-13 |
赛欧生物医药股份有限公司 |
细菌源性脂质组合物和其用途
|
|
AU2022421841A1
(en)
|
2021-12-20 |
2024-06-27 |
Sail Biomedicines, Inc. |
Mrna therapeutic compositions
|
|
WO2023220561A1
(en)
|
2022-05-09 |
2023-11-16 |
Sanegene Bio Usa Inc. |
Double stranded rna targeting 17-beta hydroxysteroiddehydrogenase 13 (hsd17b13) and methods of use thereof
|
|
JP2025516638A
(ja)
|
2022-05-13 |
2025-05-30 |
フラッグシップ パイオニアリング イノベーションズ セブン,エルエルシー |
二本鎖dna組成物及び関連する方法
|
|
AU2023320578A1
(en)
|
2022-08-05 |
2025-02-13 |
Sanegene Bio Usa Inc. |
Double stranded rna targeting angiotensinogen (agt) and methods of use thereof
|
|
WO2024081954A2
(en)
|
2022-10-14 |
2024-04-18 |
Sanegene Bio Usa Inc. |
Small interfering rna targeting c3 and uses thereof
|
|
CN120359023A
(zh)
|
2022-11-10 |
2025-07-22 |
赛欧生物医药股份有限公司 |
包含脂质纳米颗粒或脂质重构的天然信使包的rna组合物
|
|
CN120569477A
(zh)
|
2022-12-19 |
2025-08-29 |
美国圣因生物股份有限公司 |
靶向cfb的小干扰rna及其用途
|
|
AU2024212425A1
(en)
|
2023-01-27 |
2025-08-07 |
Sail Biomedicines, Inc. |
A modified lipid composition and uses thereof
|
|
IL322201A
(en)
|
2023-02-17 |
2025-09-01 |
Flagship Pioneering Innovations Vii Llc |
DNA structures containing modified uracil
|
|
EP4665856A2
(en)
|
2023-02-17 |
2025-12-24 |
Flagship Pioneering Innovations VII, LLC |
Dna compositions comprising modified cytosine
|
|
US20240309383A1
(en)
|
2023-02-24 |
2024-09-19 |
Suzhou Sanegene Bio Inc. |
Small interfering rna targeting hbv and uses thereof
|
|
WO2024186673A2
(en)
|
2023-03-03 |
2024-09-12 |
Sanegene Bio Usa Inc. |
Small interfering rna targeting apoc3 and uses thereof
|
|
WO2024220712A2
(en)
|
2023-04-19 |
2024-10-24 |
Sail Biomedicines, Inc. |
Vaccine compositions
|
|
WO2024220752A2
(en)
|
2023-04-19 |
2024-10-24 |
Sail Biomedicines, Inc. |
Rna therapeutic compositions
|
|
WO2024220625A1
(en)
|
2023-04-19 |
2024-10-24 |
Sail Biomedicines, Inc. |
Delivery of polynucleotides from lipid nanoparticles comprising rna and ionizable lipids
|
|
WO2024243438A2
(en)
|
2023-05-23 |
2024-11-28 |
Omega Therapeutics, Inc. |
Compositions and methods for reducing cxcl9, cxcl10, and cxcl11 gene expression
|
|
WO2024263915A2
(en)
|
2023-06-21 |
2024-12-26 |
Sanegene Bio Usa Inc. |
Double stranded rna targeting proprotein convertase subtilisin kexin 9 (pcsk9) and methods of use thereof
|
|
WO2025096807A2
(en)
|
2023-10-31 |
2025-05-08 |
Flagship Pioneering Innovations Vii, Llc |
Novel therapeutic dna forms
|
|
WO2025133951A1
(en)
|
2023-12-21 |
2025-06-26 |
Genevant Sciences Gmbh |
Ionizable lipids suitable for lipid nanoparticles
|
|
WO2025228441A2
(en)
|
2024-04-30 |
2025-11-06 |
Sanegene Bio Usa Inc. |
Small interfering rna targeting inhbe and uses thereof
|