MX2019008252A - Agentes de interferencia de acido ribonucleico (iarn) de alfa-1 antitripsina (aat), composiciones que incluyen agentes de iarn aat y metodos de uso. - Google Patents

Agentes de interferencia de acido ribonucleico (iarn) de alfa-1 antitripsina (aat), composiciones que incluyen agentes de iarn aat y metodos de uso.

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Publication number
MX2019008252A
MX2019008252A MX2019008252A MX2019008252A MX2019008252A MX 2019008252 A MX2019008252 A MX 2019008252A MX 2019008252 A MX2019008252 A MX 2019008252A MX 2019008252 A MX2019008252 A MX 2019008252A MX 2019008252 A MX2019008252 A MX 2019008252A
Authority
MX
Mexico
Prior art keywords
aat
rnai agents
compositions including
antitrypsin
alpha
Prior art date
Application number
MX2019008252A
Other languages
English (en)
Inventor
I Wooddell Christine
Pei Tao
Li Zhen
Zhu Rui
Original Assignee
Arrowhead Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Arrowhead Pharmaceuticals Inc filed Critical Arrowhead Pharmaceuticals Inc
Publication of MX2019008252A publication Critical patent/MX2019008252A/es

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    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
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Abstract

Se describen agentes de iARN para inhibir la expresión del gen alfa-1 antitripsina (AAT), composiciones que incluyen agente de iARN AAT y métodos para su uso, también se describen composiciones farmacéuticas que comprenden uno o más agentes de iARN AAT junto con uno o más excipientes capaces de suministrar uno o más agentes de iARN AAT a una célula hepática in vivo. El suministro de uno o más agentes de iARN AAT a células hepáticas in vivo prevé la inhibición de la expresión del gen AAT y el tratamiento de enfermedades asociadas con la deficiencia de AAT, como hepatitis crónica, cirrosis, carcinoma hepatocelular, transaminitis, colectasia, fibrosis o insuficiencia hepática fulminante.
MX2019008252A 2017-01-10 2018-01-10 Agentes de interferencia de acido ribonucleico (iarn) de alfa-1 antitripsina (aat), composiciones que incluyen agentes de iarn aat y metodos de uso. MX2019008252A (es)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US201762444452P 2017-01-10 2017-01-10
US201762486720P 2017-04-18 2017-04-18
US201762596232P 2017-12-08 2017-12-08
PCT/US2018/013102 WO2018132432A1 (en) 2017-01-10 2018-01-10 Alpha-1 antitrypsin (aat) rnai agents, compositions including aat rnai agents, and methods of use

Publications (1)

Publication Number Publication Date
MX2019008252A true MX2019008252A (es) 2019-09-06

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MX2019008252A MX2019008252A (es) 2017-01-10 2018-01-10 Agentes de interferencia de acido ribonucleico (iarn) de alfa-1 antitripsina (aat), composiciones que incluyen agentes de iarn aat y metodos de uso.
MX2024003790A MX2024003790A (es) 2017-01-10 2019-07-09 Agentes de interferencia de acido ribonucleico (iarn) de alfa-1 antitripsina (aat), composiciones que incluyen agentes de iarn aat y metodos de uso.

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US (4) US10450565B2 (es)
EP (1) EP3568482A4 (es)
JP (2) JP7258773B2 (es)
KR (2) KR20240096846A (es)
CN (1) CN110268060B (es)
AU (2) AU2018208505B2 (es)
BR (1) BR112019014282A2 (es)
CA (1) CA3045045A1 (es)
IL (2) IL267959B2 (es)
JO (1) JOP20180003B1 (es)
MX (2) MX2019008252A (es)
TW (1) TWI826365B (es)
UY (1) UY37565A (es)
WO (1) WO2018132432A1 (es)
ZA (2) ZA201903348B (es)

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IL267959B2 (en) 2017-01-10 2024-07-01 Arrowhead Pharmaceuticals Inc Alpha-1 antitrypsin (AAT) RNAi agents, preparations containing AAT RNAi agents and their uses
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CN108931653A (zh) * 2018-08-31 2018-12-04 广州华澳生物科技有限公司 一种α1- 抗胰蛋白酶免疫层析检测试剂卡及其制备方法
CR20210186A (es) * 2018-09-19 2021-06-14 Arrowhead Pharmaceuticals Inc Agentes de arni para inhibir la expresión de 17beta-hsd tipo 13 (hsd17b13), composiciones de dichos agentes, y métodos de uso
KR20220030204A (ko) * 2018-12-28 2022-03-10 서나오믹스, 인크. 치료 분자의 표적화된 전달
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WO2022162161A1 (en) * 2021-01-30 2022-08-04 E-Therapeutics Plc Conjugated oligonucleotide compounds, methods of making and uses thereof
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