MX369571B - Composicion para prevenir o tratar enfermedades del higado graso. - Google Patents

Composicion para prevenir o tratar enfermedades del higado graso.

Info

Publication number
MX369571B
MX369571B MX2016013575A MX2016013575A MX369571B MX 369571 B MX369571 B MX 369571B MX 2016013575 A MX2016013575 A MX 2016013575A MX 2016013575 A MX2016013575 A MX 2016013575A MX 369571 B MX369571 B MX 369571B
Authority
MX
Mexico
Prior art keywords
preventing
fatty liver
liver diseases
composition
treating fatty
Prior art date
Application number
MX2016013575A
Other languages
English (en)
Other versions
MX2016013575A (es
Inventor
Ha Kim Soon
Jin Kim Hyoung
Sul Park Heui
Hyun Ahn Seo
Ho Shong Min
Kyun Chung Hyo
Original Assignee
Lg Chemical Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lg Chemical Ltd filed Critical Lg Chemical Ltd
Publication of MX2016013575A publication Critical patent/MX2016013575A/es
Publication of MX369571B publication Critical patent/MX369571B/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
    • A61K31/541—Non-condensed thiazines containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/517—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

La presente invención se relaciona a una composición farmacéutica para prevenir o tratar enfermedades del hígado graso, que contiene (tetrahidropiran-4-il)-[2-fenil-5-(1,1-dioxo-tiomorfolin- 4-il)metil-1H-indol-7-il]amina o una sal farmacéuticamente aceptable de la misma como ingredientes activos. La (tetrahidropiran-4-il)-[2-fenil-5-(1,1-dioxo-tiomorfolin-4-il)met il-1H-indol-7-il] amina o una sal farmacéuticamente aceptable de la misma, de acuerdo con la presente invención, puede inhibir de manera efectiva el hígado graso, hepatitis y fibrosis del higado, y puede ser útil para prevenir o tratar NAFLD, y en particular, NASH.
MX2016013575A 2014-04-18 2015-04-17 Composicion para prevenir o tratar enfermedades del higado graso. MX369571B (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
KR20140046904 2014-04-18
PCT/KR2015/003869 WO2015160213A1 (ko) 2014-04-18 2015-04-17 지방간 질환의 예방 또는 치료용 조성물

Publications (2)

Publication Number Publication Date
MX2016013575A MX2016013575A (es) 2017-06-08
MX369571B true MX369571B (es) 2019-11-12

Family

ID=54324325

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2016013575A MX369571B (es) 2014-04-18 2015-04-17 Composicion para prevenir o tratar enfermedades del higado graso.

Country Status (10)

Country Link
US (1) US9814726B2 (es)
EP (1) EP3132795B1 (es)
JP (1) JP6490097B2 (es)
KR (1) KR102006247B1 (es)
CN (2) CN106659722A (es)
BR (1) BR112016024020A8 (es)
ES (1) ES2851006T3 (es)
MX (1) MX369571B (es)
RU (1) RU2664696C2 (es)
WO (1) WO2015160213A1 (es)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA3084728A1 (en) * 2017-12-06 2019-06-13 Basf As Fatty acid derivatives for treating non-alcoholic steatohepatitis
JPWO2021107029A1 (es) * 2019-11-26 2021-06-03
EP4136971A4 (en) * 2020-03-31 2023-11-22 Lg Chem, Ltd. ISLAND TRANSPLANT PROTECTION COMPOSITION
EP4201407A1 (en) 2020-08-19 2023-06-28 MitoImmune Therapeutics Inc. Mitochondria-targeted antioxidant as agent for treating pathologic inflammation caused by mabc-r infection
CN114470217B (zh) * 2020-11-24 2023-06-20 深圳微芯生物科技股份有限公司 预防和治疗代谢异常或炎症引起的组织损伤的药物组合物
EP4324829A1 (en) 2021-04-12 2024-02-21 MitoImmune Therapeutics Inc. Sulfate of 5-[(1,1-dioxido-4-thiomorpholinyl)methyl]-2-phenyl-n-(tetrahydro-2h-pyran-4-yl)-1h-indole-7-amine, and novel crystal form thereof
US20240043409A1 (en) 2021-04-12 2024-02-08 Mitoimmune Therapeutics Inc. Crystalline forms of 5-[(1,1-dioxido-4-thiomorpholinyl)methyl]-2-phenyl-n-(tetrahydro-2h-pyran-4-yl)-1h-indol-7-amine
AU2022324177A1 (en) 2021-08-02 2024-02-22 Mitoimmune Therapeutics Inc. Novel indole derivative, pharmaceutical composition comprising same, and use thereof
CN117794922A (zh) 2021-08-02 2024-03-29 水疗免疫疗法有限公司 吲哚衍生物、其制备方法及其用途

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2308839B1 (en) * 2005-04-20 2017-03-01 Takeda Pharmaceutical Company Limited Fused heterocyclic compounds
CA2634940A1 (en) * 2005-12-21 2007-07-05 Schering Corporation Treatment of nonalcoholic fatty liver disease using cholesterol lowering agents and h3 receptor antagonist/inverse agonist
JP5323834B2 (ja) 2007-08-17 2013-10-23 エルジー・ライフ・サイエンシーズ・リミテッド 細胞壊死阻害剤としてのインドール化合物
ES2417179T3 (es) * 2007-11-30 2013-08-06 The Regents Of The University Of California Métodos para tratar la esteatohepatitis no alcohólica (EHNA) mediante productos basados en cisteamina
JP5188583B2 (ja) * 2008-01-04 2013-04-24 エルジー・ライフ・サイエンシーズ・リミテッド 細胞、組織及び臓器保存効果を有するインドール及びインダゾール誘導体
CN102548393B (zh) * 2009-07-31 2015-06-03 斯特里克再生医学学院,斯特里克学院事务所 脂肪性肝炎-肝癌模型动物
TW201119651A (en) * 2009-10-26 2011-06-16 Lg Life Sciences Ltd Pharmaceutical composition comprising indole compound
WO2013077579A1 (ko) 2011-11-25 2013-05-30 가톨릭대학교 산학협력단 안과 질환의 예방 및 치료용 약학 조성물
KR20130087283A (ko) 2012-01-27 2013-08-06 재단법인 의약바이오컨버젼스연구단 인돌 및 인다졸 유도체를 유효성분으로 포함하는 암 전이 억제용 조성물
KR101413207B1 (ko) 2012-06-14 2014-07-01 부산대학교 산학협력단 염증성 질환의 예방 또는 치료용 약학 조성물 및 건강기능식품

Also Published As

Publication number Publication date
KR20150120877A (ko) 2015-10-28
WO2015160213A1 (ko) 2015-10-22
ES2851006T3 (es) 2021-09-02
MX2016013575A (es) 2017-06-08
BR112016024020A8 (pt) 2021-07-20
RU2664696C2 (ru) 2018-08-21
RU2016145066A (ru) 2018-05-20
CN113967215A (zh) 2022-01-25
CN106659722A (zh) 2017-05-10
EP3132795B1 (en) 2020-10-21
RU2016145066A3 (es) 2018-05-20
EP3132795A1 (en) 2017-02-22
BR112016024020A2 (pt) 2017-08-15
US9814726B2 (en) 2017-11-14
KR102006247B1 (ko) 2019-08-01
JP2017511373A (ja) 2017-04-20
US20170035776A1 (en) 2017-02-09
EP3132795A4 (en) 2017-11-29
JP6490097B2 (ja) 2019-03-27

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