MX2016011290A - Composiciones de ester de colina de acido lipoico y metodos de uso. - Google Patents

Composiciones de ester de colina de acido lipoico y metodos de uso.

Info

Publication number
MX2016011290A
MX2016011290A MX2016011290A MX2016011290A MX2016011290A MX 2016011290 A MX2016011290 A MX 2016011290A MX 2016011290 A MX2016011290 A MX 2016011290A MX 2016011290 A MX2016011290 A MX 2016011290A MX 2016011290 A MX2016011290 A MX 2016011290A
Authority
MX
Mexico
Prior art keywords
lipoic acid
choline ester
acid choline
methods
aqueous
Prior art date
Application number
MX2016011290A
Other languages
English (en)
Inventor
H Garner William
H Garner Margaret
r burns William
Original Assignee
Encore Vision Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Encore Vision Inc filed Critical Encore Vision Inc
Publication of MX2016011290A publication Critical patent/MX2016011290A/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/38—Heterocyclic compounds having sulfur as a ring hetero atom
    • A61K31/385—Heterocyclic compounds having sulfur as a ring hetero atom having two or more sulfur atoms in the same ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
    • A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
    • A61K47/183—Amino acids, e.g. glycine, EDTA or aspartame
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
    • A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
    • A61K47/186—Quaternary ammonium compounds, e.g. benzalkonium chloride or cetrimide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0048—Eye, e.g. artificial tears
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/08—Solutions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/10—Ophthalmic agents for accommodation disorders, e.g. myopia

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Ophthalmology & Optometry (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

La presente invención se relaciona con composiciones farmacéuticas que comprenden una cantidad terapéuticamente efectiva de éster de colina del ácido lipoico o derivados del mismo y un excipiente no acuoso mezclado en una solución acuosa. También se proporcionan en la presente composiciones no acuosas preparadas mezclando la cantidad terapéuticamente efectiva de éster de colina del ácido lipoico y el excipiente no acuoso. Las composiciones no acuosas además pueden mezclarse con la solución acuosa.
MX2016011290A 2014-03-03 2015-03-03 Composiciones de ester de colina de acido lipoico y metodos de uso. MX2016011290A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201461947378P 2014-03-03 2014-03-03
PCT/US2015/018505 WO2015134510A1 (en) 2014-03-03 2015-03-03 Lipoic acid choline ester compositions and methods of use

Publications (1)

Publication Number Publication Date
MX2016011290A true MX2016011290A (es) 2017-04-27

Family

ID=54055796

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2016011290A MX2016011290A (es) 2014-03-03 2015-03-03 Composiciones de ester de colina de acido lipoico y metodos de uso.

Country Status (12)

Country Link
US (2) US20160354340A1 (es)
EP (1) EP3113613A4 (es)
JP (1) JP6526066B2 (es)
KR (1) KR20160145558A (es)
CN (2) CN112641720A (es)
AU (2) AU2015227307A1 (es)
BR (1) BR112016020181A8 (es)
CA (1) CA2941518A1 (es)
IL (1) IL247529B (es)
MX (1) MX2016011290A (es)
RU (1) RU2735790C2 (es)
WO (1) WO2015134510A1 (es)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20190022059A1 (en) * 2015-09-24 2019-01-24 Encore Vision, Inc. Lipoic acid choline ester compositions and methods to generate biocompatible ophthalmic formulations
JOP20190057A1 (ar) * 2016-09-23 2019-03-24 Encore Vision Inc تركيبات استر كولين حمض الليبويك وطرق تثبيتها إلى منتجات عقار ذات صلة دوائية
US10052343B1 (en) 2017-02-03 2018-08-21 Gene Signal International Sa Sterile formulation comprising a stable phosphorothioate oligonucleotide
CN107089967A (zh) * 2017-05-12 2017-08-25 苏州富士莱医药股份有限公司 一种r‑硫辛酸胆碱酯卤化物的制备方法
CN106967044B (zh) * 2017-05-12 2019-02-22 苏州富士莱医药股份有限公司 制备r-硫辛酸胆碱酯卤化物的方法
CN109394745A (zh) * 2017-08-17 2019-03-01 博瑞生物医药（苏州）股份有限公司 一种包含左旋肉碱和β-羟基丁酸化合物的组合物
WO2020213693A1 (ja) * 2019-04-17 2020-10-22 参天製薬株式会社 リポ酸プロドラッグ
WO2020227578A1 (en) * 2019-05-07 2020-11-12 Aciont Inc. Lipoic acid formulations
CN113387923A (zh) * 2020-03-13 2021-09-14 诺华股份有限公司 硫辛酸胆碱酯盐的药物组合物及使用其的治疗方法
CN113717770B (zh) * 2020-05-25 2022-06-03 中国石油天然气股份有限公司 一种金属加工油
GB202305212D0 (en) 2023-04-06 2023-05-24 Elixa Mediscience Ltd Compounds

Family Cites Families (88)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB935962A (en) 1960-06-17 1963-09-04 Fujisawa Pharmaceutical Co Improvements in or relating to the production of 6.8-dithiooctanamides
US3855240A (en) 1969-04-28 1974-12-17 Exxon Research Engineering Co Sulfur containing heterocycles
US4210667A (en) 1979-04-19 1980-07-01 Pfizer Inc. Pharmaceutical preparations containing coumarin carboxylic acid derivatives
US4755528A (en) 1984-12-06 1988-07-05 Alcon Laboratories, Inc. High energy ionizing protective 2,3-diamino-1,4-butanedithiol; 4,5-diamino-1,2-dithiane; and N-acyl and N-alkyl derivatives thereof, compositions and method of use therefor
US6030950A (en) 1987-07-09 2000-02-29 Ohlenschlaeger; Gerhard Pharmaceutical therapeutic use of glutathione derivative
US5599903A (en) 1992-04-03 1997-02-04 Terrapin Technologies, Inc. Glutathione analogs and paralog panels comprising glutathione mimics
FR2638970A1 (fr) 1988-11-16 1990-05-18 Corbiere Jerome Nouvelles compositions pharmaceutiques agissant sur la presbytie et leur procede d'obtention
WO1993002639A1 (en) 1991-08-06 1993-02-18 Autogenesis Technologies, Inc. Injectable collagen-based compositions for making intraocular lens
US5466680A (en) 1992-03-26 1995-11-14 Cytologics, Inc. Method and compositions for enhancing white blood cell functioning on a mucosal or cutaneous surface
US5459133A (en) 1992-06-05 1995-10-17 Telor Ophthalmic Pharmaceuticals, Inc. Methods and products for treating presbyopia
AU4633793A (en) 1992-06-10 1994-01-04 Summit Technology, Inc. Correction of presbyopia by photorefractive keratectomy
EP0648118A1 (en) 1992-07-02 1995-04-19 Telor Ophthalmic Pharmaceuticals, Inc. Methods and products for treating presbyopia
ATE160222T1 (de) 1992-07-06 1997-11-15 Biomira Inc Photoaktivierung von proteinen zu konjugationszwecken
US5465737A (en) 1992-07-15 1995-11-14 Schachar; Ronald A. Treatment of presbyopia and other eye disorders
US5354331A (en) 1992-07-15 1994-10-11 Schachar Ronald A Treatment of presbyopia and other eye disorders
IL106587A (en) 1992-08-07 1998-03-10 Keravision Inc Hybrid intrastromal corneal ring
DE4345199C2 (de) 1993-05-22 1995-10-12 Asta Medica Ag Verwendung von Dihydroliponsäure zur Unterdrückung von Unverträglichkeitsreaktionen im Grenzbereich von Implantaten mit lebendem Körpergewebe
US5395356A (en) 1993-06-04 1995-03-07 Summit Technology, Inc. Correction of presbyopia by photorefractive keratectomy
US5527774A (en) 1993-07-12 1996-06-18 Girard; Louis J. Dislocation of cataractous lens by enzymatic zonulolysis
US5665770A (en) 1993-11-05 1997-09-09 Gakko Hojin Kinki Daigaku Method for treatment of cataract with radical scavenger
NZ283658A (en) 1994-04-04 1999-09-29 William R Freeman Compositions and treatment of increased intraocular pressure with phosphonyl-alkyloxy-pyrimidines/purines (nucleosides)
US6063116A (en) 1994-10-26 2000-05-16 Medarex, Inc. Modulation of cell proliferation and wound healing
US6743779B1 (en) 1994-11-29 2004-06-01 Imarx Pharmaceutical Corp. Methods for delivering compounds into a cell
US5624955A (en) 1995-05-03 1997-04-29 Regents Of The University Of Minnesota Compounds that enhance the concentration of glutathione in tissues
US5686450A (en) 1995-06-07 1997-11-11 Alcon Laboratories, Inc. Use of N,N'-bis(mercaptoacetyl) hydrazine derivatives as anticataract agents
US6007510A (en) 1996-10-25 1999-12-28 Anamed, Inc. Implantable devices and methods for controlling the flow of fluids within the body
US5817630A (en) 1997-03-18 1998-10-06 Austin Nutriceutical Corporation Glutathione antioxidant eye drops
CZ96798A3 (cs) 1997-04-02 1998-10-14 Sankyo Company Limited Deriváty dithiolanu, jejich příprava a jejich terapeutické účinky
US5843184A (en) 1998-01-26 1998-12-01 Cionni; Robert J. Endocapsular tension ring and method of implanting same
US6153647A (en) 1998-11-12 2000-11-28 My-Tech, Inc. Method for augmenting the inotropic effects of β-adrenergic agonists using pyruvate therapy
US6472541B2 (en) 1998-11-20 2002-10-29 The Regents Of The University Of California Protecting groups with increased photosensitivities
WO2000032235A1 (de) 1998-11-26 2000-06-08 Pentapharm Ag Transportsystemkonjugate
US6288106B1 (en) 1999-05-25 2001-09-11 Chronorx, Llc Processes for the synthesis and use of various α-lipoic acid complexes
US6339102B1 (en) 1999-06-09 2002-01-15 The United States Of America As Represented By The Secretary Of The Army Method and composition for treating and preventing retinal damage
JP4476435B2 (ja) * 1999-07-22 2010-06-09 株式会社細川洋行 仕切部材、複室輸液容器および薬剤入り複室輸液容器の製造方法
US6890896B1 (en) 1999-11-18 2005-05-10 Ceremedix, Inc. Compositions and methods for counteracting effects of reactive oxygen species and free radicals
US6387945B2 (en) 2000-04-11 2002-05-14 The Regents Of The University Of California Lipoic acid analogs
JP2004502484A (ja) 2000-07-10 2004-01-29 コーニンクレッカ　フィリップス　エレクトロニクス　エヌ　ヴィ 撮像医用装置に対する幾何学適合
AU2001291677A1 (en) 2000-08-02 2002-02-13 Basf Aktiengesellschaft Method for producing lipoic acid and dihydrolipoic acid
US20050112113A1 (en) 2000-08-16 2005-05-26 Till Jonathan S. Presbyopia treatment by lens alteration
US7914815B2 (en) 2000-08-16 2011-03-29 Encore Health, Llc Method for delivery of pharmaceuticals for treating or preventing presbyopia
AU2001283386A1 (en) 2000-08-16 2002-02-25 Refocus, Llc. Presbyopia treatment by lens alteration
US6923955B2 (en) 2000-08-16 2005-08-02 Newlens, Llc Presbyopia treatment by lens alteration
US8697109B2 (en) 2000-08-16 2014-04-15 Encore Health, Llc Caged mercaptan and seleno-mercaptan compounds and methods of using them
US7935332B2 (en) 2000-08-16 2011-05-03 Encore Health, Llc Presbyopia treatment by lens alteration
US8147816B2 (en) 2000-08-16 2012-04-03 Encore Health, Llc Presbyopia treatment by lens alteration
US8647612B2 (en) 2008-03-05 2014-02-11 Encore Health, Llc Dithiol compounds, derivatives, and treatment of presbyopia
DE10045059A1 (de) 2000-09-12 2002-03-21 Basf Ag Therapeutische Kombination von Liponsäure und Konjuensäuren zur Behandlung diabetischer Störungen
US6273092B1 (en) 2000-09-22 2001-08-14 Gerard M. Nolan Methods for treating various eye disorders
US6703039B2 (en) 2000-12-06 2004-03-09 Bausch & Lomb Incorporated Reversible gelling system for ocular drug delivery
JP2005506096A (ja) 2001-01-19 2005-03-03 ニューレンズ、エルエルシー 水晶体の変化による老眼治療
EP1371640B1 (en) 2001-03-19 2009-10-28 Senju Pharmaceutical Co., Ltd. Novel a-lipoic acid derivative and use thereof
WO2002096360A2 (en) 2001-05-25 2002-12-05 Ceremedix, Inc. Single amino acid based compounds for counteracting effects of reactive oxygen species and free radicals
FR2832637B1 (fr) 2001-06-07 2004-07-30 Lefaix Marie Therese Droy Utilisation d'un antioxydant pour la fabrication d'un medicament destine au traitement des affections oculaires de surface
ITMI20011232A1 (it) 2001-06-12 2002-12-12 St Microelectronics Srl Metodo di riprogrammazione successiva ad una operazione di cancellazione di una matrice di celle di memoria non volatile, in particolare di
AU2002254546A1 (en) 2002-04-03 2003-10-20 Mitchell A. Avery Lipoic acid analogs useful as provitamins and antioxidants
US20050137124A1 (en) 2002-08-09 2005-06-23 Vitreo-Retinal Technologies, Inc. A California Corporation Agents for intravitreal administration to treat or prevent disorders of the eye
CN100367949C (zh) 2002-09-13 2008-02-13 有限会社绪方研究 黑色素消除制剂
EP1551399A4 (en) * 2002-09-30 2011-01-05 Mark A Babizhayev METHOD FOR THE TOPICAL TREATMENT OF EYE DISEASES AND COMPOSITION AND DEVICE FOR THIS TREATMENT
US20060177430A1 (en) 2002-12-20 2006-08-10 Chakshu Research Inc Treatment of ocular disorders with ophthalmic formulations containing methylsulfonylmethane as a transport enhancer
US7941211B2 (en) 2003-11-17 2011-05-10 Zeavision, Llc. Preloading with macular pigment to improve photodynamic treatment of retinal vascular disorders
EP1691818A4 (en) 2003-11-25 2007-01-24 Univ Rochester COMPOUNDS FOR DELIVERING AMINO ACIDS OR PEPTIDES WITH ANTIOXIDANT ACTIVITY IN MITOCHONDRIES AND USE THEREOF
US7718697B2 (en) 2003-12-17 2010-05-18 Alcon, Inc. Method for treating glaucoma comprising administering α-lipoic acid
GB0404693D0 (en) 2004-03-02 2004-04-07 Univ London Pharmaceutical preparations for the treatment of ocular surface and other disorders
FR2869531B1 (fr) 2004-04-30 2006-07-14 Optis France Sa Sa Dispositif de iontophorese oculaire diminuant les irritations
US7264279B2 (en) 2004-07-08 2007-09-04 Fab-Tech, Inc. Segmented conduit having a monolithic lining
US20080038316A1 (en) 2004-10-01 2008-02-14 Wong Vernon G Conveniently implantable sustained release drug compositions
US20060188492A1 (en) 2005-01-13 2006-08-24 Chronorx Llc, An Alaska Limited Liability Company Topical management of ocular and periocular conditions
US20060275278A1 (en) * 2005-06-02 2006-12-07 Choy Camus K M Method and ophthalmic formulation for eye protection or treatment
EP1904108B1 (en) 2005-07-15 2011-11-30 Chakshu Research, Inc. Ophthalmological formulation comprising methylsulfonylmethane and ciprofloxacin
US20070055070A1 (en) 2005-09-07 2007-03-08 Lawrence Lowell J Novel esters of lipoic acid
US20070207116A1 (en) * 2006-03-01 2007-09-06 Brown David C Antioxidant compositions for the eye
CA2691775A1 (en) 2006-06-16 2007-12-27 Indigene Pharmaceuticals Inc. Metformin r-(+) lipoate as an antidiabetic agent for control of diabetic hyperglycemia and diabetic complications
CA2671706A1 (en) * 2006-12-08 2008-06-12 Sachtleben Chemie Gmbh Titanium-containing molded body
DE102006062599B4 (de) 2006-12-29 2018-03-08 Endress + Hauser Gmbh + Co. Kg Opto-elektronische Vorrichtung zur Übertragung eines elektrischen Signals und deren Verwendung
ES2732293T3 (es) 2007-02-22 2019-11-21 Childrens Hospital & Res Center At Oakland Formulaciones de ácidos grasos y métodos para el uso de las mismas
JP2010520333A (ja) 2007-03-01 2010-06-10 セダーズ−シナイ メディカル センター 〔１，２〕−ジチオラン部分を含有する抗酸化剤重合体およびその使用
UA86441C2 (ru) 2007-03-30 2009-04-27 Акционерное Общество Открытого Типа "Галичфарм" (2-гидроксиэтил)триметиламмония тиоктат (холина тиоктат), имеющий гепатопротекторное, гипоаммониемическое и детоксицирующее действие, способ его получения, фармацевтическая композиция на его основе
EP2179736A4 (en) * 2007-08-09 2012-01-18 Senju Pharma Co TWO COMPONENT OPHTHALMIC DROPS CONTAINING PIRENOXIN
US9044439B2 (en) 2008-03-05 2015-06-02 Encore Health, Llc Low dose lipoic and pharmaceutical compositions and methods
WO2009111635A2 (en) 2008-03-05 2009-09-11 Encore Health, Llc Dithiol compounds, derivatives, and uses therefor
ES2579173T3 (es) 2009-06-15 2016-08-05 Encore Health, Llc Ésteres de colina para tratar presbicia y cataratas
EP4082542A1 (en) * 2009-06-15 2022-11-02 Encore Health, LLC Dithiol compounds, derivatives, and uses therefor
DE102010009475B4 (de) * 2010-02-26 2011-11-24 F. Holzer Gmbh Verfahren zur Herstellung eines dosierbaren applikationsfertigen Präparates
ES2564502T3 (es) 2010-03-17 2016-03-23 Novaliq Gmbh Composición farmacéutica para el tratamiento de la presión intraocular aumentada
TR201901309T4 (tr) * 2011-01-04 2019-02-21 Novaliq Gmbh Semiflorlanmış alkanları içeren o/w emülsiyonları.
BR112014017719A8 (pt) * 2012-01-23 2017-07-11 Novaliq Gmbh Composições de proteína estabilizada baseadas em alcanos semifluorados
EP3078384A1 (en) * 2012-02-22 2016-10-12 Stealth Peptides International, Inc. Methods and compositions for preventing or treating ophthalmic conditions

Also Published As

Publication number Publication date
IL247529B (en) 2020-10-29
US11426381B2 (en) 2022-08-30
CN112641720A (zh) 2021-04-13
IL247529A0 (en) 2016-11-30
US20160354340A1 (en) 2016-12-08
BR112016020181A8 (pt) 2021-06-29
RU2735790C2 (ru) 2020-11-09
WO2015134510A1 (en) 2015-09-11
RU2016137784A (ru) 2018-04-03
EP3113613A4 (en) 2019-03-13
JP2017511816A (ja) 2017-04-27
CA2941518A1 (en) 2015-09-11
KR20160145558A (ko) 2016-12-20
AU2015227307A1 (en) 2016-10-13
AU2019240641A1 (en) 2019-10-24
RU2016137784A3 (es) 2018-10-18
US20200281891A1 (en) 2020-09-10
CN106455563A (zh) 2017-02-22
JP6526066B2 (ja) 2019-06-05
BR112016020181A2 (pt) 2017-08-15
EP3113613A1 (en) 2017-01-11
AU2019240641B2 (en) 2020-10-29

Similar Documents

Publication Publication Date Title
MX2016011290A (es) Composiciones de ester de colina de acido lipoico y metodos de uso.
PH12017501956A1 (en) Compositions of obeticholic acid and methods of use
HK1248712A1 (zh) 氘代鵝去氧膽酸衍生物以及包含該化合物的藥物組合物
MX2016016666A (es) Derivados de acido boronico y usos terapeuticos de los mismos.
EP3206706A4 (en) Stable injectable composition of pharmaceutically active agents and process for its preparation
MX2016015093A (es) Derivados de acido boronico y sus usos terapeuticos.
MX2016008978A (es) Formulaciones farmaceuticas de analogos de insulina y/o derivados de insulina estabilizadas y que estan libres de glicerol.
HK1254055A1 (zh) 製備奧貝膽酸及其衍生物的方法
MX2022011225A (es) Formulaciones farmaceuticas de un inhibidor de hidroxilasa de hif.
EP3130355A4 (en) Pharmaceutical composition containing pregabalin with improved stability and method for preparing same
EP3109230A4 (en) Class of carboxylic acid derivatives and use thereof in preparation of prodrugs
EP3102585A4 (en) Boronic acid esters and pharmaceutical formulations thereof
BR112017012406A2 (pt) formulação com relação fixa de insulina glargina/lixisenatida
EP3043811A4 (en) Compositions and methods for the delivery of molecules into live cells
EP3125944A4 (en) Methods and compositions for administering an active agent to the pleura of a patient
EP3225234A4 (en) Preparation containing chlorogenic acid crystal form and use thereof
MX2015008588A (es) Composiciones y metodos para la transfeccion de polinucleótidos.
EP3139741A4 (en) Methods and compositions comprising 10-hydroxy-2-decenoic acid
IL263982B (en) Preparations with two ingredients containing acetylsalicylic acid and sea salt of organic acids
IL262405A (en) Methods for the preparation of obeticholic acid and derivatives thereof
SG10202008700VA (en) α-TRUXILLIC ACID DERIVATIVES AND PHARMACEUTICAL COMPOSITIONS THEREOF
IL265480A (en) Preparations of choline ester of lipoic acid and a method of stabilizing them into pharmaceutical relevant drug products
IL240293B (en) Transformed histories of carboxylic acids and pharmaceutical preparations containing them
EP3153156A4 (en) Composition based on a stabilized solution of active ingredients
GB201810520D0 (en) Branched acid emulsifer compositions and methods of use