JP2014527401A5 - - Google Patents
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- JP2014527401A5 JP2014527401A5 JP2014518986A JP2014518986A JP2014527401A5 JP 2014527401 A5 JP2014527401 A5 JP 2014527401A5 JP 2014518986 A JP2014518986 A JP 2014518986A JP 2014518986 A JP2014518986 A JP 2014518986A JP 2014527401 A5 JP2014527401 A5 JP 2014527401A5
- Authority
- JP
- Japan
- Prior art keywords
- double
- acid molecule
- ribonucleic acid
- stranded ribonucleic
- nucleotides
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 229920002477 rna polymer Polymers 0.000 claims 37
- 125000003729 nucleotide group Chemical group 0.000 claims 22
- 239000002773 nucleotide Substances 0.000 claims 20
- 108091081021 Sense strand Proteins 0.000 claims 14
- 230000000692 anti-sense effect Effects 0.000 claims 10
- IQFYYKKMVGJFEH-XLPZGREQSA-N Thymidine Chemical compound O=C1NC(=O)C(C)=CN1[C@@H]1O[C@H](CO)[C@@H](O)C1 IQFYYKKMVGJFEH-XLPZGREQSA-N 0.000 claims 8
- 150000007523 nucleic acids Chemical group 0.000 claims 8
- 241000700721 Hepatitis B virus Species 0.000 claims 6
- 108090000623 proteins and genes Proteins 0.000 claims 6
- 108091028043 Nucleic acid sequence Proteins 0.000 claims 5
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 4
- ISAKRJDGNUQOIC-UHFFFAOYSA-N Uracil Chemical compound O=C1C=CNC(=O)N1 ISAKRJDGNUQOIC-UHFFFAOYSA-N 0.000 claims 4
- 230000002401 inhibitory effect Effects 0.000 claims 4
- 239000008194 pharmaceutical composition Substances 0.000 claims 4
- 108091032973 (ribonucleotides)n+m Proteins 0.000 claims 2
- 230000000295 complement effect Effects 0.000 claims 2
- 108020004999 messenger RNA Proteins 0.000 claims 2
- 108020004707 nucleic acids Proteins 0.000 claims 2
- 102000039446 nucleic acids Human genes 0.000 claims 2
- 230000007918 pathogenicity Effects 0.000 claims 2
- 102000004169 proteins and genes Human genes 0.000 claims 2
- 229940035893 uracil Drugs 0.000 claims 2
- 230000029812 viral genome replication Effects 0.000 claims 2
- 208000035657 Abasia Diseases 0.000 claims 1
- HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol group Chemical group [C@@H]1(CC[C@H]2[C@@H]3CC=C4C[C@@H](O)CC[C@]4(C)[C@H]3CC[C@]12C)[C@H](C)CCCC(C)C HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 claims 1
- 239000003085 diluting agent Substances 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 238000000338 in vitro Methods 0.000 claims 1
- 125000001921 locked nucleotide group Chemical group 0.000 claims 1
- 238000012986 modification Methods 0.000 claims 1
- 230000004048 modification Effects 0.000 claims 1
- 125000004573 morpholin-4-yl group Chemical group N1(CCOCC1)* 0.000 claims 1
- ONKSSDKXDIVIHK-UHFFFAOYSA-N n,n-didecyldodecanamide Chemical group CCCCCCCCCCCC(=O)N(CCCCCCCCCC)CCCCCCCCCC ONKSSDKXDIVIHK-UHFFFAOYSA-N 0.000 claims 1
- PTMHPRAIXMAOOB-UHFFFAOYSA-L phosphoramidate Chemical compound NP([O-])([O-])=O PTMHPRAIXMAOOB-UHFFFAOYSA-L 0.000 claims 1
- 239000003381 stabilizer Substances 0.000 claims 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP11172235.1 | 2011-06-30 | ||
| EP11172235 | 2011-06-30 | ||
| US13/535,454 | 2012-06-28 | ||
| US13/535,454 US8809293B2 (en) | 2011-06-30 | 2012-06-28 | Compositions and methods for inhibiting gene expression of hepatitis B virus |
| PCT/US2012/044505 WO2013003520A1 (en) | 2011-06-30 | 2012-06-28 | Compositions and methods for inhibiting gene expression of hepatitis b virus |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017073870A Division JP2017169568A (ja) | 2011-06-30 | 2017-04-03 | Ｂ型肝炎ウイルスの遺伝子発現を阻害するための組成物および方法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2014527401A JP2014527401A (ja) | 2014-10-16 |
| JP2014527401A5 true JP2014527401A5 (enExample) | 2015-08-06 |
| JP6165723B2 JP6165723B2 (ja) | 2017-07-19 |
Family
ID=47391267
Family Applications (5)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014518986A Active JP6165723B2 (ja) | 2011-06-30 | 2012-06-28 | Ｂ型肝炎ウイルスの遺伝子発現を阻害するための組成物および方法 |
| JP2017073870A Withdrawn JP2017169568A (ja) | 2011-06-30 | 2017-04-03 | Ｂ型肝炎ウイルスの遺伝子発現を阻害するための組成物および方法 |
| JP2019078663A Active JP6959293B2 (ja) | 2011-06-30 | 2019-04-17 | Ｂ型肝炎ウイルスの遺伝子発現を阻害するための組成物および方法 |
| JP2021130741A Pending JP2021191274A (ja) | 2011-06-30 | 2021-08-10 | Ｂ型肝炎ウイルスの遺伝子発現を阻害するための組成物および方法 |
| JP2023150873A Pending JP2023179497A (ja) | 2011-06-30 | 2023-09-19 | Ｂ型肝炎ウイルスの遺伝子発現を阻害するための組成物および方法 |
Family Applications After (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017073870A Withdrawn JP2017169568A (ja) | 2011-06-30 | 2017-04-03 | Ｂ型肝炎ウイルスの遺伝子発現を阻害するための組成物および方法 |
| JP2019078663A Active JP6959293B2 (ja) | 2011-06-30 | 2019-04-17 | Ｂ型肝炎ウイルスの遺伝子発現を阻害するための組成物および方法 |
| JP2021130741A Pending JP2021191274A (ja) | 2011-06-30 | 2021-08-10 | Ｂ型肝炎ウイルスの遺伝子発現を阻害するための組成物および方法 |
| JP2023150873A Pending JP2023179497A (ja) | 2011-06-30 | 2023-09-19 | Ｂ型肝炎ウイルスの遺伝子発現を阻害するための組成物および方法 |
Country Status (21)
| Country | Link |
|---|---|
| US (2) | US8809293B2 (enExample) |
| EP (3) | EP3901263A1 (enExample) |
| JP (5) | JP6165723B2 (enExample) |
| KR (5) | KR102025295B1 (enExample) |
| CN (3) | CN103635576B (enExample) |
| AU (5) | AU2012275355B2 (enExample) |
| BR (1) | BR112013031021A2 (enExample) |
| CA (2) | CA3064103C (enExample) |
| DK (1) | DK2726613T3 (enExample) |
| EA (4) | EA202090994A1 (enExample) |
| ES (1) | ES2690538T3 (enExample) |
| HR (1) | HRP20181564T1 (enExample) |
| IL (3) | IL230226B (enExample) |
| MX (2) | MX342731B (enExample) |
| PL (1) | PL2726613T3 (enExample) |
| PT (1) | PT2726613T (enExample) |
| SG (1) | SG194751A1 (enExample) |
| SI (1) | SI2726613T1 (enExample) |
| TW (5) | TWI695066B (enExample) |
| WO (1) | WO2013003520A1 (enExample) |
| ZA (1) | ZA201307914B (enExample) |
Families Citing this family (80)
| Publication number | Priority date | Publication date | Assignee | Title |
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| EP3587574B1 (en) | 2010-08-17 | 2022-03-16 | Sirna Therapeutics, Inc. | Rna interference mediated inhibition of hepatitis b virus (hbv) gene expression using short interfering nucleic acid (sina) |
| SG10201604074TA (en) | 2011-04-21 | 2016-07-28 | Isis Pharmaceuticals Inc | Modulation of hepatitis b virus (hbv) expression |
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| IN2015DN01087A (enExample) | 2012-08-30 | 2015-06-26 | Replicor Inc | |
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| US10227588B2 (en) | 2013-10-04 | 2019-03-12 | Novartis Ag | 3′end caps for RNAi agents for use in RNA interference |
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| EP3052627B1 (en) | 2013-10-04 | 2018-08-22 | Novartis AG | Novel formats for organic compounds for use in rna interference |
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| WO2016011123A1 (en) * | 2014-07-16 | 2016-01-21 | Arrowhead Research Corporation | Organic compositions to treat apoc3-related diseases |
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| US10898505B2 (en) * | 2015-05-06 | 2021-01-26 | Benitec Biopharma Limited | Reagents for treatment of hepatitis B virus (HBV) infection and use thereof |
| US20170137821A1 (en) | 2015-07-17 | 2017-05-18 | Arcturus Therapeutics, Inc. | Molecules and agents for treating hepatitis b virus |
| CA2996722A1 (en) * | 2015-07-17 | 2017-01-26 | Arcturus Therapeutics, Inc. | Compositions and agents against hepatitis b virus and uses thereof |
| CN108350455A (zh) * | 2015-07-29 | 2018-07-31 | 阿布特斯生物制药公司 | 用于使b型肝炎病毒基因表达沉默的组合物和方法 |
| JO3769B1 (ar) * | 2015-08-07 | 2021-01-31 | Arrowhead Pharmaceuticals Inc | علاج RNAi لعدوى فيروس التهاب الكبد B |
| CN108271387B (zh) * | 2015-08-07 | 2023-06-27 | 箭头药业股份有限公司 | 乙型肝炎病毒感染的RNAi疗法 |
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| CN108713061B (zh) * | 2016-03-09 | 2022-04-05 | 学校法人东京理科大学 | Rna杂交形成用核酸低聚物 |
| RU2747822C2 (ru) | 2016-03-14 | 2021-05-14 | Ф. Хоффманн-Ля Рош Аг | Олигонуклеотиды для понижения экспрессии pd-l1 |
| KR102358280B1 (ko) * | 2016-05-05 | 2022-02-07 | 베니텍 바이오파마 리미티드 | B형 간염 바이러스(hbv) 감염 처리용 시약 및 그 용도 |
| MA45496A (fr) | 2016-06-17 | 2019-04-24 | Hoffmann La Roche | Molécules d'acide nucléique pour la réduction de l'arnm de padd5 ou pad7 pour le traitement d'une infection par l'hépatite b |
| JOP20170161A1 (ar) * | 2016-08-04 | 2019-01-30 | Arrowhead Pharmaceuticals Inc | عوامل RNAi للعدوى بفيروس التهاب الكبد ب |
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| CN117402852A (zh) * | 2016-10-14 | 2024-01-16 | 精密生物科学公司 | 对乙肝病毒基因组中的识别序列特异性的工程化大范围核酸酶 |
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| EP3601216B1 (en) | 2017-03-21 | 2023-10-25 | Arbutus Biopharma Corporation | Substituted dihydroindene-4-carboxamides and analogs thereof, and methods using same for the treatment of hepatitis b virus infection |
| CN110520531A (zh) | 2017-04-05 | 2019-11-29 | 赛伦斯治疗有限责任公司 | 产品和组合物 |
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| KR102720270B1 (ko) | 2017-04-18 | 2024-10-23 | 알닐람 파마슈티칼스 인코포레이티드 | B형 간염 바이러스 (hbv)에 감염된 대상체의 치료 방법 |
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